Christian Carpene

Summary

Country: France

Publications

  1. ncbi Adipogenesis-related increase of semicarbazide-sensitive amine oxidase and monoamine oxidase in human adipocytes
    Sandy Bour
    U858 INSERM, I2MR, IFR 31, CHU Rangueil, BP 84225, 31432 Toulouse Cedex 4, France
    Biochimie 89:916-25. 2007
  2. ncbi Expanding role for the apelin/APJ system in physiopathology
    C Carpene
    INSERM, U858, Toulouse, F 31432 France
    J Physiol Biochem 63:359-73. 2007
  3. doi Limitation of adipose tissue enlargement in rats chronically treated with semicarbazide-sensitive amine oxidase and monoamine oxidase inhibitors
    C Carpene
    Institut National de la Sante et de la Recherche Medicale, INSERM U858 équipe 3, F 31432 Toulouse, France
    Pharmacol Res 57:426-34. 2008
  4. ncbi Reduction of fat deposition by combined inhibition of monoamine oxidases and semicarbazide-sensitive amine oxidases in obese Zucker rats
    C Carpene
    Institut National de la Sante et de la Recherche Medicale, INSERM U858 équipe 3, Universite Paul Sabatier, IFR31, Centre Hospitalier Universitaire de Rangueil, BP 84225, 31432 Toulouse Cedex 4, France
    Pharmacol Res 56:522-30. 2007
  5. ncbi Effects of histamine on triglyceride breakdown in mouse adipocytes
    C Carpene
    INSERM U586, IFR 31, Bat L3, CHU Rangueil, 31432 Toulouse, France
    Inflamm Res 56:S41-2. 2007
  6. ncbi Amine oxidase substrates for impaired glucose tolerance correction
    C Carpene
    INSERM U586, IFR 31, Bat L3, CHU Rangueil, Université P Sabatier, BP 84225, 31342 Toulouse, France
    J Physiol Biochem 61:405-19. 2005
  7. ncbi Short- and long-term insulin-like effects of monoamine oxidases and semicarbazide-sensitive amine oxidase substrates in cultured adipocytes
    Christian Carpene
    Institut National de la Sante et de la Recherche Medicale, U586 INSERM, IFR 31, CHU Rangueil, 31432 Toulouse Cedex 4, France
    Metabolism 55:1397-405. 2006
  8. ncbi Glucose handling in streptozotocin-induced diabetic rats is improved by tyramine but not by the amine oxidase inhibitor semicarbazide
    Virgile Visentin
    Institut National de la Sante et de la Recherche Medicale, U586, IFR 31, Bat L3, CHU Rangueil, Toulouse, France
    Eur J Pharmacol 522:139-46. 2005
  9. ncbi The imidazoline I2-site ligands BU 224 and 2-BFI inhibit MAO-A and MAO-B activities, hydrogen peroxide production, and lipolysis in rodent and human adipocytes
    Sandy Bour
    INSERM, U586, Unité de Recherches sur les Obésités, Universite Paul Sabatier, IFR31, CHU Rangueil, Toulouse, F 31432, France
    Eur J Pharmacol 552:20-30. 2006
  10. ncbi Inhibition of rat fat cell lipolysis by monoamine oxidase and semicarbazide-sensitive amine oxidase substrates
    Virgile Visentin
    Institut Louis Bugnard, Institut National de la Sante et de la Recherche Medicale, Unité 586, C H U Rangueil, Toulouse Cedex F 31403, France
    Eur J Pharmacol 466:235-43. 2003

Collaborators

Detail Information

Publications28

  1. ncbi Adipogenesis-related increase of semicarbazide-sensitive amine oxidase and monoamine oxidase in human adipocytes
    Sandy Bour
    U858 INSERM, I2MR, IFR 31, CHU Rangueil, BP 84225, 31432 Toulouse Cedex 4, France
    Biochimie 89:916-25. 2007
    ....
  2. ncbi Expanding role for the apelin/APJ system in physiopathology
    C Carpene
    INSERM, U858, Toulouse, F 31432 France
    J Physiol Biochem 63:359-73. 2007
    ..This review will consider the main roles of apelin in physiopathology with particular attention on its role in energy balance regulation and in obesity-associated disorders...
  3. doi Limitation of adipose tissue enlargement in rats chronically treated with semicarbazide-sensitive amine oxidase and monoamine oxidase inhibitors
    C Carpene
    Institut National de la Sante et de la Recherche Medicale, INSERM U858 équipe 3, F 31432 Toulouse, France
    Pharmacol Res 57:426-34. 2008
    ..These observations suggest that SSAO inhibition is not sufficient to impair fat deposition. However, combined MAO and SSAO inhibition limits adiposity in non-obese as well as in obese rats...
  4. ncbi Reduction of fat deposition by combined inhibition of monoamine oxidases and semicarbazide-sensitive amine oxidases in obese Zucker rats
    C Carpene
    Institut National de la Sante et de la Recherche Medicale, INSERM U858 équipe 3, Universite Paul Sabatier, IFR31, Centre Hospitalier Universitaire de Rangueil, BP 84225, 31432 Toulouse Cedex 4, France
    Pharmacol Res 56:522-30. 2007
    ....
  5. ncbi Effects of histamine on triglyceride breakdown in mouse adipocytes
    C Carpene
    INSERM U586, IFR 31, Bat L3, CHU Rangueil, 31432 Toulouse, France
    Inflamm Res 56:S41-2. 2007
  6. ncbi Amine oxidase substrates for impaired glucose tolerance correction
    C Carpene
    INSERM U586, IFR 31, Bat L3, CHU Rangueil, Université P Sabatier, BP 84225, 31342 Toulouse, France
    J Physiol Biochem 61:405-19. 2005
    ..In regard with this influence on metabolic control, more attention must be paid to the composition or supplementation in amines in foods and nutraceutics...
  7. ncbi Short- and long-term insulin-like effects of monoamine oxidases and semicarbazide-sensitive amine oxidase substrates in cultured adipocytes
    Christian Carpene
    Institut National de la Sante et de la Recherche Medicale, U586 INSERM, IFR 31, CHU Rangueil, 31432 Toulouse Cedex 4, France
    Metabolism 55:1397-405. 2006
    ..Therefore, like SSAO, substrate activation of MAO can interact with adipocyte metabolism by mimicking diverse effects of insulin in addition to preventing tumor necrosis factor alpha-dependent responses...
  8. ncbi Glucose handling in streptozotocin-induced diabetic rats is improved by tyramine but not by the amine oxidase inhibitor semicarbazide
    Virgile Visentin
    Institut National de la Sante et de la Recherche Medicale, U586, IFR 31, Bat L3, CHU Rangueil, Toulouse, France
    Eur J Pharmacol 522:139-46. 2005
    ..It is therefore concluded that amine oxidase activation by increased substrate supply elicits insulin-like actions that may be more beneficial in diabetes than SSAO inhibition formerly proposed to prevent vascular complications...
  9. ncbi The imidazoline I2-site ligands BU 224 and 2-BFI inhibit MAO-A and MAO-B activities, hydrogen peroxide production, and lipolysis in rodent and human adipocytes
    Sandy Bour
    INSERM, U586, Unité de Recherches sur les Obésités, Universite Paul Sabatier, IFR31, CHU Rangueil, Toulouse, F 31432, France
    Eur J Pharmacol 552:20-30. 2006
    ..Taken together, our observations demonstrate on WAT novel effects of BU 224 and 2-BFI different from their already reported actions on brain or endocrine pancreas...
  10. ncbi Inhibition of rat fat cell lipolysis by monoamine oxidase and semicarbazide-sensitive amine oxidase substrates
    Virgile Visentin
    Institut Louis Bugnard, Institut National de la Sante et de la Recherche Medicale, Unité 586, C H U Rangueil, Toulouse Cedex F 31403, France
    Eur J Pharmacol 466:235-43. 2003
    ..These data suggest that inhibition of lipolysis is a novel insulin-like effect of amine oxidase substrates which is mediated by hydrogen peroxide generated during amine oxidation...
  11. ncbi Benzylamine exhibits insulin-like effects on glucose disposal, glucose transport, and fat cell lipolysis in rabbits and diabetic mice
    Maria Carmen Iglesias-Osma
    Unité de Recherches sur les Obésités, Institut National de la Santé et de la Recherche Médicale U586, Centre Hospitalier Universitaire de Toulouse, Universite Paul Sabatier, France
    J Pharmacol Exp Ther 309:1020-8. 2004
    ..Together, our results bring evidence that benzylamine on its own can improve glucose tolerance in rabbit and mouse, likely by stimulating glucose uptake via amine oxidase activation in insulin-sensitive tissues...
  12. doi SSAO substrates exhibiting insulin-like effects in adipocytes as a promising treatment option for metabolic disorders
    Josep Mercader
    Institut National de la Sante et de la Recherche Medicale, INSERM U858 équipe 3, Universite Paul Sabatier, IFR150, Centre Hospitalier Universitaire de Rangueil, France
    Future Med Chem 2:1735-49. 2010
    ..Benzylamine exerts insulin-like effects in adipocytes (e.g., glucose uptake and antilipolysis) and improves glucose handling in rodents...
  13. ncbi Adipose tissue proadipogenic redox changes in obesity
    Anne Galinier
    Unite Mixte de Recherche 5018 CNRS, Universite Paul Sabatier, Institut Fedératif Recherche 31, Institut Louis Bugnard, BP 84225, 31432 Toulouse Cedex 4, France
    J Biol Chem 281:12682-7. 2006
    ..Taken together and contrary to the emergent view, our results suggest that obesity is associated with an intracellular reduced redox state that promotes on its own the development of a deleterious proadipogenic process...
  14. doi Apelin stimulates glucose utilization in normal and obese insulin-resistant mice
    Cedric Dray
    Institut National de la Sante et de la Recherche Medicale, U858, Toulouse, France
    Cell Metab 8:437-45. 2008
    ..Remarkably, in obese and insulin-resistant mice, apelin restored glucose tolerance and increased glucose utilization. Apelin could thus represent a promising target in the management of insulin resistance...
  15. ncbi Alteration of amine oxidase activity in the adipose tissue of obese subjects
    Virgile Visentin
    Institut National de la Sante et de la Recherche Medicale, Centre Hospitalier Universitaire Rangueil, Toulouse, France
    Obes Res 12:547-55. 2004
    ....
  16. doi Benzylamine antihyperglycemic effect is abolished by AOC3 gene invalidation in mice but not rescued by semicarbazide-sensitive amine oxidase expression under the control of aP2 promoter
    Sandra Gres
    Institut National de la Santé et de la Recherche Médicale INSERM U1048, I2MC, CHU Rangueil, 31432 Toulouse, France
    J Physiol Biochem 68:651-62. 2012
    ....
  17. ncbi TNFalpha up-regulates apelin expression in human and mouse adipose tissue
    Danièle Daviaud
    INSERM, U586, Unité de Recherches sur les Obésités, Universite Paul Sabatier, Institut Louis Bugnard IFR31, Toulouse, France
    FASEB J 20:1528-30. 2006
    ..All together, these findings suggest that apelin might be a candidate to better understand potential links between obesity and associated disorders such as inflammation and insulin resistance...
  18. doi Chronic benzylamine administration in the drinking water improves glucose tolerance, reduces body weight gain and circulating cholesterol in high-fat diet-fed mice
    Zsuzsa Iffiú-Soltész
    INSERM, U858, Institut de Medecine Moleculaire de Rangueil, IFR 150, Toulouse, France
    Pharmacol Res 61:355-63. 2010
    ....
  19. doi The amine oxidase inhibitor phenelzine limits lipogenesis in adipocytes without inhibiting insulin action on glucose uptake
    Christian Carpene
    Institut National de la Sante et de la Recherche Medicale, U 1048 Bat L4, Team 3, CHU Rangueil, Toulouse, France
    J Neural Transm 120:997-1003. 2013
    ..Nonetheless, phenelzine antilipogenic action is not merely dependent on SSAO/PrAO inhibition...
  20. ncbi Tyramine stimulates glucose uptake in insulin-sensitive tissues in vitro and in vivo via its oxidation by amine oxidases
    Nathalie Morin
    Institut National de la Sante et de la Recherche Medicale, Toulouse, France
    J Pharmacol Exp Ther 303:1238-47. 2002
    ..In conclusion, activation of the amine oxidases present in insulin-sensitive tissues induces insulin-like effects, readily detectable in vitro, and increasing peripheral glucose utilization in vivo...
  21. doi Isopropylnorsynephrine is a stronger lipolytic agent in human adipocytes than synephrine and other amines present in Citrus aurantium
    Josep Mercader
    INSERM U1048, Universite de Toulouse, UPS, Institut de Médecine, Moléculaire de Rangueil, Toulouse, France
    J Physiol Biochem 67:443-52. 2011
    ..This compound, not detected in C. aurantium, and which has few reported adverse effects to date, might be useful for in vivo triglyceride breakdown...
  22. doi Increased primary amine oxidase expression and activity in white adipose tissue of obese and diabetic db-/- mice
    Zsuzsa Iffiú-Soltész
    Universite de Toulouse, UPS, Institut de Médecine Moléculaire de Rangueil I2MC, Toulouse, France
    J Neural Transm 118:1071-7. 2011
    ..Such higher amount of AT-bound primary amine oxidase warrants further studies to determine whether SSAO/VAP-1 inhibition or activation may be useful in treating metabolic diseases...
  23. pmc Semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 deficiency reduces leukocyte infiltration into adipose tissue and favors fat deposition
    Sandy Bour
    INSERM U858, Equipe 3, I2MR, Universite Toulouse III Paul Sabatier, CHU Rangueil, Bat L4, BP 84225, 31432 Toulouse Cedex 4, France
    Am J Pathol 174:1075-83. 2009
    ..Our results indicate that SSAO/VAP-1 is instrumental for the presence of leukocytes in WAT. Therefore, AOC3-KO mice present a unique model of mild obesity, characterized by increased WAT devoid of low-grade inflammation...
  24. doi 5-hydroxytryptamine actions in adipocytes: involvement of monoamine oxidase-dependent oxidation and subsequent PPARγ activation
    Sandra Gres
    Universite de Toulouse, UPS, Institut de Médecine Moléculaire de Rangueil I2MC, Toulouse, France
    J Neural Transm 120:919-26. 2013
    ..Such pathway could be involved in the adverse effects of several antidepressant SSRIs on body weight gain...
  25. ncbi Involvement of cholecystokinin 2 receptor in food intake regulation: hyperphagia and increased fat deposition in cholecystokinin 2 receptor-deficient mice
    Pascal Clerc
    Institut National de la Sante et de la Recherche Medicale Unit 531, Institut Fédératif de Recherche 31, Université de Toulouse 3, 31432 Toulouse Cedex 4, France
    Endocrinology 148:1039-49. 2007
    ..Our results give evidence that CCK2 receptor activity plays a contributing regulatory role in the control of food intake...
  26. doi Resveratrol directly affects in vitro lipolysis and glucose transport in human fat cells
    Saioa Gómez-Zorita
    I2MC, Universite de Toulouse, UPS, Toulouse, France
    J Physiol Biochem 69:585-93. 2013
    ..Consequently, our data indicate that resveratrol can be considered as limiting fat accumulation in human fat cells and further support its use for the mitigation of obesity...
  27. doi Oxidation of high doses of serotonin favors lipid accumulation in mouse and human fat cells
    Sandra Gres
    Institut des Maladies Métaboliques et Cardiovasculaires I2MC, Universite de Toulouse, UPS, Toulouse, France
    Mol Nutr Food Res 57:1089-99. 2013
    ..Since this nuclear factor manages lipid handling by adipose tissue, the response of fat cells to 5-HT exposure needed further investigation...
  28. pmc Oral Administration of Semicarbazide Limits Weight Gain together with Inhibition of Fat Deposition and of Primary Amine Oxidase Activity in Adipose Tissue
    Josep Mercader
    Institut National de la Sante et de la Recherche Medicale, INSERM U1048, Equipe 3, 12MC, IFR 150, Bat L4, CHU Rangueil, BP 84225, 31432 Toulouse Cedex 4, France
    J Obes 2011:475786. 2011
    ....