Pablo Carbonell

Summary

Country: France

Publications

  1. ncbi request reprint Molecular signatures-based prediction of enzyme promiscuity
    Pablo Carbonell
    iSSB, Institute of Systems and Synthetic Biology, University of Evry, Evry, France
    Bioinformatics 26:2012-9. 2010
  2. ncbi request reprint Retrosynthetic design of heterologous pathways
    Pablo Carbonell
    Institute of Systems and Synthetic Biology ISSB, Evry, France
    Methods Mol Biol 985:149-73. 2013
  3. doi request reprint Stereo signature molecular descriptor
    Pablo Carbonell
    University of Evry, CNRS, Institute of Systems and Synthetic Biology, Evry, France
    J Chem Inf Model 53:887-97. 2013
  4. pmc Enumerating metabolic pathways for the production of heterologous target chemicals in chassis organisms
    Pablo Carbonell
    iSSB, Institute of Systems and Synthetic Biology, University of Evry, Genopole Campus 1, Genavenir 6, 5 rue Henri Desbrueres, 91030 Evry Cedex, France
    BMC Syst Biol 6:10. 2012
  5. ncbi request reprint Compound toxicity screening and structure-activity relationship modeling in Escherichia coli
    Anne Gaëlle Planson
    iSSB, Institute of Systems and Synthetic Biology, University of Evry, Genopole Campus 1, Genavenir 6, 5 rue Henri Desbrueres, 91030 Evry Cedex, France
    Biotechnol Bioeng 109:846-50. 2012
  6. pmc Origins of specificity and promiscuity in metabolic networks
    Pablo Carbonell
    Institute of Systems and Synthetic Biology, University of Evry, 91030 Evry, France
    J Biol Chem 286:43994-4004. 2011
  7. ncbi request reprint Retropath: automated pipeline for embedded metabolic circuits
    Pablo Carbonell
    Univ Evry, CNRS, iSSB, F 91000 Evry, France
    ACS Synth Biol 3:565-77. 2014
  8. doi request reprint A retrosynthetic biology approach to therapeutics: from conception to delivery
    Anne Gaëlle Planson
    iSSB, Institute of Systems and Synthetic Biology, CNRS UPS3509, University of Evry Val d Essonne EA4527, Genopole Campus 1, Genavenir 6, 5 rue Henri Desbrueres, 91030 Evry Cedex, France
    Curr Opin Biotechnol 23:948-56. 2012
  9. pmc A retrosynthetic biology approach to metabolic pathway design for therapeutic production
    Pablo Carbonell
    Institute of Systems and Synthetic Biology, University of Evry, Genopole Campus 1, Genavenir 6, 5 rue Henri Desbrueres, Evry Cedex, France
    BMC Syst Biol 5:122. 2011
  10. pmc XTMS: pathway design in an eXTended metabolic space
    Pablo Carbonell
    University of Evry, iSSB, F 91000 Evry, France CNRS, iSSB, F 91000 Evry, France
    Nucleic Acids Res 42:W389-94. 2014

Detail Information

Publications10

  1. ncbi request reprint Molecular signatures-based prediction of enzyme promiscuity
    Pablo Carbonell
    iSSB, Institute of Systems and Synthetic Biology, University of Evry, Evry, France
    Bioinformatics 26:2012-9. 2010
    ..Here, we introduce for the first time a method for predicting catalytic and substrate promiscuity using a graph-based representation known as molecular signature...
  2. ncbi request reprint Retrosynthetic design of heterologous pathways
    Pablo Carbonell
    Institute of Systems and Synthetic Biology ISSB, Evry, France
    Methods Mol Biol 985:149-73. 2013
    ....
  3. doi request reprint Stereo signature molecular descriptor
    Pablo Carbonell
    University of Evry, CNRS, Institute of Systems and Synthetic Biology, Evry, France
    J Chem Inf Model 53:887-97. 2013
    ..The complete source code of the stereo signature molecular descriptor is available for download under an open-source license at http://molsig.sourceforge.net...
  4. pmc Enumerating metabolic pathways for the production of heterologous target chemicals in chassis organisms
    Pablo Carbonell
    iSSB, Institute of Systems and Synthetic Biology, University of Evry, Genopole Campus 1, Genavenir 6, 5 rue Henri Desbrueres, 91030 Evry Cedex, France
    BMC Syst Biol 6:10. 2012
    ..We follow a retrosynthetic approach in order to search in the metabolic space (hypergraphs) for pathways (hyperpaths) linking the target compounds to a source set of compounds...
  5. ncbi request reprint Compound toxicity screening and structure-activity relationship modeling in Escherichia coli
    Anne Gaëlle Planson
    iSSB, Institute of Systems and Synthetic Biology, University of Evry, Genopole Campus 1, Genavenir 6, 5 rue Henri Desbrueres, 91030 Evry Cedex, France
    Biotechnol Bioeng 109:846-50. 2012
    ..coli toxicity prediction web server based on QSAR models (EcoliTox server: http://www.issb.genopole.fr/∼faulon/EcoliTox.php)...
  6. pmc Origins of specificity and promiscuity in metabolic networks
    Pablo Carbonell
    Institute of Systems and Synthetic Biology, University of Evry, 91030 Evry, France
    J Biol Chem 286:43994-4004. 2011
    ..In this way, results presented in this paper might assist us with the identification of primeval promiscuous catalytic functions contributing to life's minimal metabolism...
  7. ncbi request reprint Retropath: automated pipeline for embedded metabolic circuits
    Pablo Carbonell
    Univ Evry, CNRS, iSSB, F 91000 Evry, France
    ACS Synth Biol 3:565-77. 2014
    ..In that way, design and implementation of applications such as therapeutic circuits that autonomously diagnose and treat disease, are enabled, and their optimization is streamlined. ..
  8. doi request reprint A retrosynthetic biology approach to therapeutics: from conception to delivery
    Anne Gaëlle Planson
    iSSB, Institute of Systems and Synthetic Biology, CNRS UPS3509, University of Evry Val d Essonne EA4527, Genopole Campus 1, Genavenir 6, 5 rue Henri Desbrueres, 91030 Evry Cedex, France
    Curr Opin Biotechnol 23:948-56. 2012
    ..The aim of this review is to highlight recent efforts toward synthetic design for therapeutic development...
  9. pmc A retrosynthetic biology approach to metabolic pathway design for therapeutic production
    Pablo Carbonell
    Institute of Systems and Synthetic Biology, University of Evry, Genopole Campus 1, Genavenir 6, 5 rue Henri Desbrueres, Evry Cedex, France
    BMC Syst Biol 5:122. 2011
    ..So far, a wider adoption of retrosynthesis into the manufacturing pipeline has been hindered by the complexity of enumerating all feasible biosynthetic pathways for a given compound...
  10. pmc XTMS: pathway design in an eXTended metabolic space
    Pablo Carbonell
    University of Evry, iSSB, F 91000 Evry, France CNRS, iSSB, F 91000 Evry, France
    Nucleic Acids Res 42:W389-94. 2014
    ..By answering such critical design points, XTMS not only paves the road toward the rationalization of metabolic engineering, but also opens new processing possibilities for non-natural metabolites and novel enzymatic transformations. ..