J Capeau

Summary

Country: France

Publications

  1. ncbi request reprint Association between altered expression of adipogenic factor SREBP1 in lipoatrophic adipose tissue from HIV-1-infected patients and abnormal adipocyte differentiation and insulin resistance
    Jean Philippe Bastard
    INSERM Research Unit 402, Faculty of Medicine Saint Antoine, Paris, France
    Lancet 359:1026-31. 2002
  2. ncbi request reprint Bile salts potentiate adenylyl cyclase activity and cAMP-regulated secretion in human gallbladder epithelium
    Nicolas Chignard
    Institut National de la Sante et de la Recherche Medicale, Hopital Saint Antoine, 75012 Paris, France
    Am J Physiol Gastrointest Liver Physiol 284:G205-12. 2003
  3. ncbi request reprint [Insulin signaling: mechanisms altered in insulin resistance]
    Jacqueline Capeau
    INSERM U 402, Hopital Tenon, Faculte de Medecine Saint Antoine, Universite Pierre et Marie Curie, 27, rue Chaligny, 75571 Paris Cedex 12, Paris, France
    Med Sci (Paris) 19:834-9. 2003
  4. ncbi request reprint Antiretroviral drugs with adverse effects on adipocyte lipid metabolism and survival alter the expression and secretion of proinflammatory cytokines and adiponectin in vitro
    Claire Lagathu
    INSERM U402 and IFR65 Saint Antoine Faculty of Medicine and Biochemistry Department, Tenon Hospital, University Pierre et Marie Curie, Paris, France
    Antivir Ther 9:911-20. 2004
  5. ncbi request reprint [Lipodystrophic syndromes: congenital or acquired diseases of adipose tissue]
    Jacqueline Capeau
    INSERM, U680, Universite Pierre et Marie Curie, site Saint Antoine, Faculte de Medecine, 27, rue Chaligny, 75571 Paris Cedex 12, France
    C R Biol 329:639-52; discussion 653-5. 2006
  6. ncbi request reprint [Lipodystrophies related to antiretroviral treatment of HIV infection]
    Jacqueline Capeau
    INSERM U680, Faculté de Médecine et Université Pierre et Marie Curie, Hopital Tenon AP HP, 27, rue Chaligny, 75012 Paris, France
    Med Sci (Paris) 22:531-6. 2006
  7. ncbi request reprint [Insulin signaling: mechanisms altered in insulin resistance]
    Jacqueline Capeau
    Faculte de Medecine Saint Antoine, Universite Pierre et Marie Curie, 27, rue Chaligny, 75571 Paris Cedex 12, Paris, France
    Med Sci (Paris) 21:34-9. 2005
  8. ncbi request reprint Adverse metabolic disorders during highly active antiretroviral treatments (HAART) of HIV disease
    C Vigouroux
    Service de Biochimie, Hopital Rothschild, Paris, France
    Diabetes Metab 25:383-92. 1999
  9. ncbi request reprint Diseases of adipose tissue: genetic and acquired lipodystrophies
    J Capeau
    INSERM U680, Saint Antoine Faculty of Medicine, Université Pierre et Marie Curie UPMC, Paris, France
    Biochem Soc Trans 33:1073-7. 2005
  10. ncbi request reprint Survival and functions of encapsulated porcine hepatocytes after allotransplantation or xenotransplantation without immunosuppression
    S Benoist
    Research Unit 402 of INSERM, Paris, France
    Surgery 129:606-16. 2001

Detail Information

Publications94

  1. ncbi request reprint Association between altered expression of adipogenic factor SREBP1 in lipoatrophic adipose tissue from HIV-1-infected patients and abnormal adipocyte differentiation and insulin resistance
    Jean Philippe Bastard
    INSERM Research Unit 402, Faculty of Medicine Saint Antoine, Paris, France
    Lancet 359:1026-31. 2002
    ..In-vitro studies show that HIV-1-protease inhibitors affect adipocyte differentiation at an early step involving sterol-regulatory-element-binding-protein-1 (SREBP1), but in-vivo studies are lacking...
  2. ncbi request reprint Bile salts potentiate adenylyl cyclase activity and cAMP-regulated secretion in human gallbladder epithelium
    Nicolas Chignard
    Institut National de la Sante et de la Recherche Medicale, Hopital Saint Antoine, 75012 Paris, France
    Am J Physiol Gastrointest Liver Physiol 284:G205-12. 2003
    ..Through this action, bile salts may increase fluid secretion in the gallbladder after feeding...
  3. ncbi request reprint [Insulin signaling: mechanisms altered in insulin resistance]
    Jacqueline Capeau
    INSERM U 402, Hopital Tenon, Faculte de Medecine Saint Antoine, Universite Pierre et Marie Curie, 27, rue Chaligny, 75571 Paris Cedex 12, Paris, France
    Med Sci (Paris) 19:834-9. 2003
    ..A deleterious role for molecules issued from the adipose tissue is postulated in the resistance to insulin of the liver and muscles present in type 2 diabetes, obesity and metabolic syndrome...
  4. ncbi request reprint Antiretroviral drugs with adverse effects on adipocyte lipid metabolism and survival alter the expression and secretion of proinflammatory cytokines and adiponectin in vitro
    Claire Lagathu
    INSERM U402 and IFR65 Saint Antoine Faculty of Medicine and Biochemistry Department, Tenon Hospital, University Pierre et Marie Curie, Paris, France
    Antivir Ther 9:911-20. 2004
    ..We examined the direct effects of individual antiretrovirals on lipid metabolism and cytokine and adiponectin production by cultured adipocytes...
  5. ncbi request reprint [Lipodystrophic syndromes: congenital or acquired diseases of adipose tissue]
    Jacqueline Capeau
    INSERM, U680, Universite Pierre et Marie Curie, site Saint Antoine, Faculte de Medecine, 27, rue Chaligny, 75571 Paris Cedex 12, France
    C R Biol 329:639-52; discussion 653-5. 2006
    ..Acquired forms are common and regroup the highly prevalent Metabolic Syndrome, hypercorticism together with lipodystrophy related to antiretroviral treatment of HIV-infected patients...
  6. ncbi request reprint [Lipodystrophies related to antiretroviral treatment of HIV infection]
    Jacqueline Capeau
    INSERM U680, Faculté de Médecine et Université Pierre et Marie Curie, Hopital Tenon AP HP, 27, rue Chaligny, 75012 Paris, France
    Med Sci (Paris) 22:531-6. 2006
    ..The treatment of lipodystrophy remains difficult and, at present, privileges the switch of the more deleterious drugs towards new molecules less aggressive for adipose tissue...
  7. ncbi request reprint [Insulin signaling: mechanisms altered in insulin resistance]
    Jacqueline Capeau
    Faculte de Medecine Saint Antoine, Universite Pierre et Marie Curie, 27, rue Chaligny, 75571 Paris Cedex 12, Paris, France
    Med Sci (Paris) 21:34-9. 2005
    ..A deleterious role for molecules issued from the adipose tissue is postulated in the resistance to insulin of the liver and muscles present in type 2 diabetes, obesity and metabolic syndrome...
  8. ncbi request reprint Adverse metabolic disorders during highly active antiretroviral treatments (HAART) of HIV disease
    C Vigouroux
    Service de Biochimie, Hopital Rothschild, Paris, France
    Diabetes Metab 25:383-92. 1999
    ..Studies are in progress to evaluate the possibility of therapeutic alternatives to PI when major metabolic disturbances are present...
  9. ncbi request reprint Diseases of adipose tissue: genetic and acquired lipodystrophies
    J Capeau
    INSERM U680, Saint Antoine Faculty of Medicine, Université Pierre et Marie Curie UPMC, Paris, France
    Biochem Soc Trans 33:1073-7. 2005
    ..Such syndromes help to understand the mechanisms involved in insulin resistance resulting from altered fat repartition and could benefit from insulin-sensitizing effects of lifestyle modifications or of specific medications...
  10. ncbi request reprint Survival and functions of encapsulated porcine hepatocytes after allotransplantation or xenotransplantation without immunosuppression
    S Benoist
    Research Unit 402 of INSERM, Paris, France
    Surgery 129:606-16. 2001
    ..The demonstration of maintained hepatic functions in transplanted porcine hepatocytes up to 15 days is a first step toward application in the treatment of acute liver failure...
  11. ncbi request reprint [Major insulin resistance syndromes: clinical and physiopathological aspects]
    C Vigouroux
    Unité INSERM 402, Faculte de Medecine Saint Antoine, 27, rue Chaligny, 75571 Paris
    J Soc Biol 195:249-57. 2001
    ....
  12. ncbi request reprint Insulin-mediated cell proliferation and survival involve inhibition of c-Jun N-terminal kinases through a phosphatidylinositol 3-kinase- and mitogen-activated protein kinase phosphatase-1-dependent pathway
    C Desbois-Mouthon
    INSERM U 402, Faculte de Medecine Saint Antoine, Paris, France
    Endocrinology 141:922-31. 2000
    ..Altogether, these results demonstrate that insulin inhibits JNKs through a PI 3-K- and MKP-1-dependent pathway and provide evidence for a key role for JNK inhibition in insulin regulation of proliferation and survival...
  13. ncbi request reprint Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss
    J P Bastard
    Service de Biochimie, Hopital de la Salpetriere, Paris, France
    J Clin Endocrinol Metab 85:3338-42. 2000
    ..The reduced production and serum concentrations after weight loss could play a role in the improved sensitivity to insulin observed in these patients...
  14. ncbi request reprint The HIV protease inhibitor indinavir impairs sterol regulatory element-binding protein-1 intranuclear localization, inhibits preadipocyte differentiation, and induces insulin resistance
    M Caron
    Institut National de la Santé et de la Recherche Médicale INSERM U 402, Faculte de Medecine Saint Antoine, 27, rue Chaligny, 75571 Paris Cedex 12, France
    Diabetes 50:1378-88. 2001
    ..Hence, indinavir impairs differentiation at an early step of adipose conversion probably involving the process controlling SREBP-1 intranuclear localization...
  15. ncbi request reprint The nuclear pore complex is involved in nuclear transfer of plasmid DNA condensed with an oligolysine-RGD peptide containing nuclear localisation properties
    M Colin
    INSERM U402, , Paris, France
    Gene Ther 8:1643-53. 2001
    ..We propose that the oligolysine-RGD peptide acts as a nuclear localisation signal and that the cationic lipid is more important for cell entry and endosome destabilisation than nuclear transfer...
  16. ncbi request reprint Human lipodystrophies linked to mutations in A-type lamins and to HIV protease inhibitor therapy are both associated with prelamin A accumulation, oxidative stress and premature cellular senescence
    M Caron
    INSERM U680, Universite Pierre et Marie Curie Paris 6, Faculte de Medecine, site Saint Antoine, 27 rue Chaligny, 75571 Paris Cedex 12, France
    Cell Death Differ 14:1759-67. 2007
    ..These alterations could participate in the pathophysiology of lipodystrophic syndromes and lead to premature ageing complications...
  17. ncbi request reprint Long-term treatment with interleukin-1beta induces insulin resistance in murine and human adipocytes
    C Lagathu
    INSERM, U680, Université Pierre et Marie Curie UPMC Paris 6, Faculty of Medicine, 27 rue Chaligny, 75012, Paris, France
    Diabetologia 49:2162-73. 2006
    ..Adipose tissue inflammation has recently been implicated in the pathogenesis of insulin resistance and is probably linked to high local levels of cytokines. IL1B, a proinflammatory cytokine, may participate in this alteration...
  18. ncbi request reprint Enterocytic differentiation of the human Caco-2 cell line correlates with alterations in integrin signaling
    P Levy
    INSERM U 402, Faculte de Medecine Saint Antoine, Paris, France
    J Cell Physiol 177:618-27. 1998
    ....
  19. ncbi request reprint A new missense mutation in the calcium-sensing receptor in familial benign hypercalcaemia associated with partial lipoatrophy and insulin resistant diabetes
    C Vigouroux
    INSERM U402, Faculte de Medecine Saint Antoine, Paris, France
    Clin Endocrinol (Oxf) 53:393-8. 2000
    ..1998). This mutation is therefore likely to be responsible of the FBHH phenotype. A pathophysiological link between this mutation and insulin resistance remains unclear...
  20. ncbi request reprint Survival and differentiation of porcine hepatocytes encapsulated by semiautomatic device and allotransplanted in large number without immunosuppression
    S Benoist
    Research Unit 402, INSERM, Hospital Saint-Antoine, Paris, France
    J Hepatol 35:208-16. 2001
    ..CONCLUSIONS: The preservation of hepatocyte functions during 1-2 weeks is encouraging for potential short-term use of such bioartificial liver in future clinical application...
  21. ncbi request reprint Insulin and IGF-1 stimulate the beta-catenin pathway through two signalling cascades involving GSK-3beta inhibition and Ras activation
    C Desbois-Mouthon
    INSERM U.402, , Paris, France
    Oncogene 20:252-9. 2001
    ..These findings demonstrate for the first time the ability of insulin and IGF-1 to activate the beta-catenin pathway in hepatoma cells and thereby provide new insights into the role of these factors in hepatocarcinogenesis...
  22. ncbi request reprint Molecular analysis of the insulin receptor gene for prenatal diagnosis of leprechaunism in two families
    C Desbois-Mouthon
    Unité INSERM 402, Faculte de Medecine Saint Antoine, Paris, France
    Prenat Diagn 17:657-63. 1997
    ..This methodology allowed us to correctly predict the genotype of the two fetuses at the IR locus...
  23. ncbi request reprint The human nm23-H4 gene product is a mitochondrial nucleoside diphosphate kinase
    L Milon
    INSERM U402, Faculte de Medecine Saint Antoine, 27 rue Chaligny, 75012 Paris, France
    J Biol Chem 275:14264-72. 2000
    ..Submitochondrial fractionation indicates that Nm23-H4 is associated with mitochondrial membranes, possibly to the contact sites between the outer and inner membranes...
  24. doi request reprint Insulin resistance and steatosis in humans
    J Capeau
    Univ Paris 6, Inserm UMR_S893 Equipe 9, Faculte de Medecine Pierre et Marie Curie, 75571 Paris Cedex 12, France
    Diabetes Metab 34:649-57. 2008
    ....
  25. ncbi request reprint [Primary lipodystrophies]
    J Capeau
    INSERM, U680, 75012 Paris, France
    Ann Endocrinol (Paris) 68:10-20. 2007
    ..The prognosis is linked to the precocity and severity of the diabetic, cardiovascular and liver complications...
  26. ncbi request reprint Increased adiponectin receptor-1 expression in adipose tissue of impaired glucose-tolerant obese subjects during weight loss
    M J Kim
    INSERM U 680, Faculte de Medecine, Universite Pierre et Marie Curie, 75012 Paris, France
    Eur J Endocrinol 155:161-5. 2006
    ....
  27. ncbi request reprint Cytoskeletal association of the A and B nucleoside diphosphate kinases of interphasic but not mitotic human carcinoma cell lines: specific nuclear localization of the B subunit
    V P Pinon
    INSERM U402, CHU Saint Antoine, Paris, France
    Exp Cell Res 246:355-67. 1999
    ..Their altered localization in dividing cells suggests colocalization with yet unidentified structures which are not intermediate filament aggregates...
  28. ncbi request reprint Insulin action is mimicked by polyclonal antireceptor antibodies that activate the insulin receptor tyrosine kinase
    M Caron
    Laboratoire de Biochimie, INSERM U181, , Paris, France
    Horm Metab Res 21:295-300. 1989
    ..Taken together, these results are consistent with a role for the kinase activity of the insulin receptor in mediating the action of insulin...
  29. ncbi request reprint HIV antiretroviral treatment alters adipokine expression and insulin sensitivity of adipose tissue in vitro and in vivo
    Claire Lagathu
    Inserm U 680 and IFR65, Universite Pierre et Marie Curie, Faculte de Medecine Saint Antoine, 27, rue Chaligny, 75571 Paris Cedex 12, France
    Biochimie 87:65-71. 2005
    ..Therefore, they could be involved in whole body insulin resistance and metabolic alterations in lipodystrophic HIV-1-infected patients...
  30. ncbi request reprint [Lipodystrophies]
    L Fardet
    Inserm UMR S938, Centre de Recherche Saint Antoine, 75012 Paris, France UMPC, Universite Paris 6, 75012 Paris, France Service de Médecine Interne, Hopital Saint Antoine, AP HP, 184, rue du Faubourg Saint Antoine, 75012 Paris, France Electronic address
    Rev Med Interne 34:614-22. 2013
    ..New therapies such as leptin have been proven to be helpful in some genetic or acquired forms of lipodystrophy. ..
  31. ncbi request reprint Etiological investigations in apparent type 2 diabetes: when to search for lamin A/C mutations?
    B Donadille
    INSERM U680, Pierre and Marie Curie Faculty of Medicine, site Saint Antoine, 27 rue de Chaligny, 75571 Paris Cedex 12, France
    Diabetes Metab 31:527-32. 2005
    ..In addition, the molecular screening of family members allows an earlier efficient clinical management of affected relatives...
  32. ncbi request reprint Metabolic disorders and chronic viral disease: the case of HIV and HCV
    L Slama
    Service des Maladies Infectieuses, Hopital Tenon, AP HP, 4, rue de la Chine, 75970 Paris Cedex 20, France
    Diabetes Metab 35:1-11. 2009
    ..Recent data indicate that HCV clearance improves insulin resistance and hepatic function in HCV-infected patients treated with interferon with or without ribavirin...
  33. ncbi request reprint Identification of the gene altered in Berardinelli-Seip congenital lipodystrophy on chromosome 11q13
    J Magre
    INSERM U 402, Faculte de Medecine Saint Antoine, Universite Pierre et Marie Curie, 27 rue Chaligny, 75012 Paris, France
    Nat Genet 28:365-70. 2001
    ..These findings are of general importance for understanding the molecular mechanisms underlying regulation of body fat distribution and insulin resistance...
  34. pmc Syndecan-1 alterations during the tumorigenic progression of human colonic Caco-2 cells induced by human Ha-ras or polyoma middle T oncogenes
    P Levy
    Laboratoire de Biologie Cellulaire, INSERM U 402, , Paris, France
    Br J Cancer 74:423-31. 1996
    ....
  35. ncbi request reprint Mitochondrial toxicity of indinavir, stavudine and zidovudine involves multiple cellular targets in white and brown adipocytes
    Say Viengchareun
    INSERM, U693, Faculte de Medecine Paris Sud, Le Kremlin Bicetre, France
    Antivir Ther 12:919-29. 2007
    ..To evaluate the mechanisms of mitochondrial toxicity associated with antiretroviral treatment...
  36. ncbi request reprint A 6-month interruption of antiretroviral therapy improves adipose tissue function in HIV-infected patients: the ANRS EP29 Lipostop Study
    Min Ji Kim
    INSERM, U680, Paris, F 75012, France
    Antivir Ther 12:1273-83. 2007
    ..To examine the reversibility of adipose tissue alterations in HIV-infected patients after a 6-month interruption of antiretroviral therapy (ART)...
  37. ncbi request reprint Some HIV antiretrovirals increase oxidative stress and alter chemokine, cytokine or adiponectin production in human adipocytes and macrophages
    Claire Lagathu
    INSERM, U680, Paris, France
    Antivir Ther 12:489-500. 2007
    ....
  38. ncbi request reprint Serum adipocytokines are related to lipodystrophy and metabolic disorders in HIV-infected men under antiretroviral therapy
    Corinne Vigouroux
    INSERM U 402, Faculte de Medecine Saint Antoine, Paris, France
    AIDS 17:1503-11. 2003
    ....
  39. ncbi request reprint Adipocytes targets and actors in the pathogenesis of HIV-associated lipodystrophy and metabolic alterations
    Marie Lise Gougeon
    Unité d Immunité Anti virale, Biothérapie et Vaccins, Département de Médecine Moléculaire, Institut Pasteur, Paris, France
    Antivir Ther 9:161-77. 2004
    ....
  40. ncbi request reprint Deletion of Asn281 in the alpha-subunit of the human insulin receptor causes constitutive activation of the receptor and insulin desensitization
    C Desbois-Mouthon
    INSERM U 402, Paris, France
    J Clin Endocrinol Metab 81:719-27. 1996
    ..These findings strongly suggest that Asn281 of the IR alpha-subunit plays a critical role in the inhibitory constraint exerted by the extracellular alpha-subunit over the intracellular kinase activity...
  41. ncbi request reprint Nuclear envelope disorganization in fibroblasts from lipodystrophic patients with heterozygous R482Q/W mutations in the lamin A/C gene
    C Vigouroux
    INSERM U 402, Faculte de Medecine Saint Antoine, 75012 Paris, France
    J Cell Sci 114:4459-68. 2001
    ..These structural nuclear alterations were caused by the lamins A/C mutations, as the same changes were introduced in human control fibroblasts by ectopic expression of R482W mutated lamin A...
  42. ncbi request reprint GSK-3beta inhibition by lithium confers resistance to chemotherapy-induced apoptosis through the repression of CD95 (Fas/APO-1) expression
    Eleonore Beurel
    INSERM U 402, Faculte de Medecine Saint Antoine, Paris, France
    Exp Cell Res 300:354-64. 2004
    ..Our study also highlights the concerted action of GSK-3beta and p53 on CD95 gene expression...
  43. ncbi request reprint GSK-3beta reactivation with LY294002 sensitizes hepatoma cells to chemotherapy-induced apoptosis
    Eleonore Beurel
    INSERM U 402, Faculte de Medecine Saint Antoine, Paris, France
    Int J Oncol 27:215-22. 2005
    ..Therefore, PI3K-mediated GSK-3beta inhibition could be a mechanism by which cancer cells escape from chemotherapy-induced apoptosis...
  44. ncbi request reprint The HIV-1 nucleoside reverse transcriptase inhibitors stavudine and zidovudine alter adipocyte functions in vitro
    Martine Caron
    INSERM U402, Faculte de Medecine Saint Antoine, Universite Pierre et Marie Curie, Paris, France
    AIDS 18:2127-36. 2004
    ..Nucleoside analogues are suspected of playing a role in peripheral fat loss in patients during long-term treatment with antiretroviral drugs...
  45. pmc Mitochondrial DNA content, an inaccurate biomarker of mitochondrial alteration in human immunodeficiency virus-related lipodystrophy
    Min Ji Kim
    INSERM, U582, Paris, F 75013 France
    Antimicrob Agents Chemother 52:1670-6. 2008
    ..The preservation of mtDNA-dependent mitochondrial functions occurred despite severe mtDNA depletion. The presence of significant oxidative stress and apoptosis did not correlate with the mtDNA content...
  46. pmc Human lipodystrophies: genetic and acquired diseases of adipose tissue
    Jacqueline Capeau
    INSERM, U938, CdR Saint Antoine, Paris, France
    Endocr Dev 19:1-20. 2010
    ..Treatment of fat redistribution can sometimes benefit from plastic surgery. Lipid and glucose alterations are difficult to control leading to early occurrence of diabetic, cardiovascular and hepatic complications...
  47. ncbi request reprint Altered fat differentiation and adipocytokine expression are inter-related and linked to morphological changes and insulin resistance in HIV-1-infected lipodystrophic patients
    Véronique Jan
    INSERM Research Unit 402, Faculty of Medicine Saint Antoine, Paris, France
    Antivir Ther 9:555-64. 2004
    ....
  48. ncbi request reprint Contribution of mitochondrial dysfunction and oxidative stress to cellular premature senescence induced by antiretroviral thymidine analogues
    Martine Caron
    INSERM, U680, Paris, 75012 France
    Antivir Ther 13:27-38. 2008
    ..In this regard, we examined whether NRTIs could accelerate the senescence of cultured cells...
  49. ncbi request reprint Prevalence of mutations in AGPAT2 among human lipodystrophies
    Jocelyne Magré
    INSERM U 402, Saint Antoine Faculty of Medicine, University of Pierre and Marie Curie, 27 rue Chaligny, 75571 Paris Cedex, France
    Diabetes 52:1573-8. 2003
    ..Because we found mutations in 92 of the 94 BSCL patients studied, the seipin gene and AGPAT2 are the two major genes involved in the etiology of BSCL...
  50. ncbi request reprint Adipose tissue as a target of HIV-1 antiretroviral drugs. Potential consequences on metabolic regulations
    Martine Caron-Debarle
    INSERM, UMRS_938, CdR Saint Antoine, 75012 Paris, France
    Curr Pharm Des 16:3352-60. 2010
    ..ART can also be directly responsible for metabolic alterations. Strategies to revert or reduce lipodystrophy are important to consider in these patients in addition to the required control of the metabolic disorders...
  51. ncbi request reprint Dysregulation of glycogen synthase kinase-3beta signaling in hepatocellular carcinoma cells
    Christele Desbois-Mouthon
    INSERM U 402, Faculte de Medecine Saint Antoine, Paris, France
    Hepatology 36:1528-36. 2002
    ..Persistent phosphorylation of GSK-3beta could be critical for regulation of glycogen metabolism and cell growth in hepatoma cells...
  52. ncbi request reprint Butyrate-treated colonic Caco-2 cells exhibit defective integrin-mediated signaling together with increased apoptosis and differentiation
    Peggy Lévy
    INSERM U 402, Faculte de Medecine Saint Antoine, rue Chaligny, Paris Cedex, France
    J Cell Physiol 197:336-47. 2003
    ..Our results indicate that the prodifferentiating agent NaBT induced apoptosis of Caco-2 cells probably through NF-kappaB activation together with a defective beta1 integrin-FAK-PI 3-kinase pathways signaling...
  53. ncbi request reprint Systemic low-grade inflammation is related to both circulating and adipose tissue TNFalpha, leptin and IL-6 levels in obese women
    M Maachi
    Service de Biochimie et Hormonologie, Hopital Tenon, AP HP, France
    Int J Obes Relat Metab Disord 28:993-7. 2004
    ..We assessed the relationships between four circulating acute phase proteins and the circulating and adipose tissue levels of three adipocytokines...
  54. doi request reprint How can we measure insulin sensitivity/resistance?
    B Antuna-Puente
    Unité mixte de recherche S938, Centre de Recherche Saint Antoine, Institut National de la Sante et de la Recherche Medicale, Universite Pierre et Marie Curie Paris 6, 27, rue Chaligny, 75571 Paris Cedex 12, France
    Diabetes Metab 37:179-88. 2011
    ..The aim of this review is to analyze the most frequently used assay methods in an attempt to evaluate when and why these methods may be useful...
  55. doi request reprint HIV-associated lipodystrophy: from fat injury to premature aging
    Martine Caron-Debarle
    INSERM, U938, CdR Saint Antoine, 75012 Paris, France
    Trends Mol Med 16:218-29. 2010
    ..We propose that adipose tissue injury by HIV and cART induces fat hypertrophy or atrophy and contributes to premature aging...
  56. ncbi request reprint Chronic interleukin-6 (IL-6) treatment increased IL-6 secretion and induced insulin resistance in adipocyte: prevention by rosiglitazone
    Claire Lagathu
    INSERM U 402 and IFR65 Saint Antoine Faculty of Medicine, Paris, France
    Biochem Biophys Res Commun 311:372-9. 2003
    ..Finally, the effects of IL-6 could be prevented by rosiglitazone, an insulin-sensitizing agent. Thus, IL-6 may play an important role in the set-up of insulin resistance in adipose cell...
  57. doi request reprint Premature senescence of vascular cells is induced by HIV protease inhibitors: implication of prelamin A and reversion by statin
    Chloé Lefèvre
    Faculté deMédecine Saint Antoine, Institut National de la Santé et de la Recherche Scientifique, Saint Antoine Research Center, Unité Mixte de Recherche S 938, Paris, France
    Arterioscler Thromb Vasc Biol 30:2611-20. 2010
    ..To determine whether and how protease inhibitors (PIs) could affect vascular aging...
  58. ncbi request reprint New metabolic phenotypes in laminopathies: LMNA mutations in patients with severe metabolic syndrome
    Aurélie Decaudain
    INSERM U680, Paris, F 75012 France
    J Clin Endocrinol Metab 92:4835-44. 2007
    ..We report here the phenotypes of the patients with non-codon 482 mutations and compare them with those of 11 patients with codon 482 mutations. We also studied skin fibroblasts or lymphocytes from seven patients...
  59. ncbi request reprint Altered hepatic expression of SREBP-1 and PPARgamma is associated with liver injury in insulin-resistant lipodystrophic HIV-infected patients
    Maud Lemoine
    Universite Pierre et Marie Curie, Faculte de Medecine, Paris, F 75012 France
    AIDS 20:387-95. 2006
    ..Here, we examined whether their expression was modified and related to liver injury in HIV-infected patients...
  60. ncbi request reprint Some HIV protease inhibitors alter lamin A/C maturation and stability, SREBP-1 nuclear localization and adipocyte differentiation
    Martine Caron
    INSERM U 402, Faculte de Medecine Saint Antoine, Paris, France
    AIDS 17:2437-44. 2003
    ..To study whether HIV protease inhibitors could induce nuclear lamina alterations in adipocytes as observed in a genetic form of lipodystrophy due to lamin A/C mutation...
  61. doi request reprint Diagnostic value of procalcitonin in acutely hospitalized elderly patients
    O Steichen
    Unité de gériatrie, Service de Medecine Interne, AP HP, Hopital Tenon, 4 rue de la Chine, 75020 Paris, France
    Eur J Clin Microbiol Infect Dis 28:1471-6. 2009
    ..Despite a good overall diagnostic accuracy, the clinical usefulness of PCT to diagnose invasive bacterial infections in elderly patients hospitalized in an acute geriatric ward appears to be very limited...
  62. ncbi request reprint Glycoconjugate metabolism in a cystic fibrosis knockout mouse model
    C Mailleau
    Institut National de la Santé et de la Recherche Médicale U 402, Faculte de Medecine Saint Antoine, University Paris VI, Paris, France
    Mol Genet Metab 72:122-31. 2001
    ....
  63. ncbi request reprint Efficient adenoviral transduction of 3T3-F442A preadipocytes without affecting adipocyte differentiation
    Veronique Bereziat
    INSERM U 680, Faculte de Medecine Saint Antoine, Universite Pierre et Marie Curie, 27, rue Chaligny, 75571 Paris Cedex 12, France
    Biochimie 87:951-8. 2005
    ..These approaches could be of interest to study fat cell differentiation and the functions of mature adipocytes...
  64. ncbi request reprint [Factors associated with hyperhomocysteinemia in Crohn's disease]
    F Maire
    Service d Hepato Gastroenterologie, Hopital Rothschild, Paris, France
    Gastroenterol Clin Biol 25:745-8. 2001
    ..The aims were: 1) to assess the prevalence of hyperhomocysteinemia in a large series of patients with Crohn's disease; 2) to search for clinical and biological factors associated with hyperhomocysteinemia...
  65. ncbi request reprint Bile acid transport and regulating functions in the human biliary epithelium
    N Chignard
    , , , , Paris, France
    Hepatology 33:496-503. 2001
    ..The differential effect of TUDC may cause a reduction in bile inspissation and provide a benefit in biliary disorders...
  66. ncbi request reprint Gene transfer by adenovirus-mimetic peptides in the presence of a cationic lipid and/or adenovirus. Analysis of the contribution of the viral and nonviral components
    S Moritz
    INSERM U402, Faculte de Medecine Saint Antoine, Paris, France
    Arch Virol 148:1-18. 2003
    ....
  67. ncbi request reprint A new human nm23 homologue (nm23-H5) specifically expressed in testis germinal cells
    A Munier
    INSERM U402, Faculte de Medecine Saint Antoine, Paris, France
    FEBS Lett 434:289-94. 1998
    ..However, under usual assay conditions, Nm23-H5 expressed in Escherichia coli did not exhibit NDP kinase activity. These results suggest that Nm23-H5 is specifically involved in early stages of spermatogenesis...
  68. ncbi request reprint Semiautomatic macroencapsulation of fresh or cryopreserved porcine hepatocytes maintain their ability for treatment of acute liver failure
    R Sarkis
    Research Unit 402, INSERM, Paris, France
    Cell Transplant 10:601-7. 2001
    ..Cryopreserved cells were as efficient as fresh hepatocytes...
  69. ncbi request reprint nm23-H4, a new member of the family of human nm23/nucleoside diphosphate kinase genes localised on chromosome 16p13
    L Milon
    INSERM U 402, Faculte de Medecine Saint Antoine, Paris, France
    Hum Genet 99:550-7. 1997
    ..Nm23-H4 naturally possesses the Pro-Ser substitution equivalent to the K-pn mutation (P97S) of Drosophila...
  70. doi request reprint Serum adipokine levels predictive of liver injury in non-alcoholic fatty liver disease
    Maud Lemoine
    Faculte de Medecine, Universite Pierre et Marie Curie, Paris, France
    Liver Int 29:1431-8. 2009
    ....
  71. doi request reprint Seipin deficiency alters fatty acid Delta9 desaturation and lipid droplet formation in Berardinelli-Seip congenital lipodystrophy
    Emilie Boutet
    INSERM, UMR, CdR Saint Antoine, Paris, France
    Biochimie 91:796-803. 2009
    ..These findings provide new insights into how seipin deficiency causes severe lipodystrophy...
  72. ncbi request reprint HIV protease inhibitors activate the adipocyte renin angiotensin system
    Franck Boccara
    Faculte de Medecine Saint Antoine, INSERM, UMRS938, Paris, France
    Antivir Ther 15:363-75. 2010
    ..Whether hypertension and cardiovascular events could result from the adipocyte renin angiotensin system (RAS) overactivation has never been investigated...
  73. doi request reprint Hepatitis C, insulin resistance and diabetes: clinical and pathogenic data
    Lawrence Serfaty
    UPMC University Paris 06, F 75005, Paris, France
    Liver Int 29:13-25. 2009
    ....
  74. ncbi request reprint Type A insulin resistance syndrome revealing a novel lamin A mutation
    Jacques Young
    Saint Antoine Faculty of Medicine, INSERM U680, 27 rue Chaligny, 75 571 Paris Cedex 12, France
    Diabetes 54:1873-8. 2005
    ..This study further extends the vast range of diseases linked to LMNA mutations and identifies another genetic cause for the type A insulin resistance syndrome...
  75. pmc Inappropriately low glycated hemoglobin values and hemolysis in HIV-infected patients
    Marie Emilienne Diop
    AP HP, Hopital Tenon, Service de biochimie et d hormonologie, and Université Pierre et Marie Curie Paris 6, Faculte de Medecine, F 75020 France
    AIDS Res Hum Retroviruses 22:1242-7. 2006
    ..Self-monitoring of blood glucose and search for latent hemolysis should be promoted in diabetic HIV-infected patients...
  76. ncbi request reprint Nm23/NDP kinases in human male germ cells: role in spermiogenesis and sperm motility?
    Annie Munier
    INSERM U402, Faculte de Medecine Saint Antoine, 75012 Paris, France
    Exp Cell Res 289:295-306. 2003
    ..In ejaculated spermatozoa, the proteins presented specific locations in the head and flagella. Nm23/NDP kinase isoforms may have specific functions in the phosphotransfer network involved in spermiogenesis and flagellar movement...
  77. ncbi request reprint Recent advances in the relationship between obesity, inflammation, and insulin resistance
    Jean Philippe Bastard
    INSERM U680, Faculte de Medecine Pierre et Marie Curie, site Saint Antoine, Universite Pierre et Marie Curie, Paris 6 et Service de Biochimie et Hormonologie, Hopital Tenon, AP HP, 75970 Paris Cedex 20, France
    Eur Cytokine Netw 17:4-12. 2006
    ..Thus, it can be considered that obesity corresponds to a sub-clinical inflammatory condition that promotes the production of pro-inflammatory factors involved in the pathogenesis of insulin resistance...
  78. ncbi request reprint Differences in both glycosylation and binding properties between rat and mouse liver prolactin receptors
    O Lascols
    Laboratorie de Biologie Cellulaire, I N S E R M U402, Faculte de Medecine Saint Antoine, Paris, France
    Cell Mol Biol (Noisy-le-grand) 40:359-71. 1994
    ....
  79. doi request reprint Rosiglitazone for nonalcoholic steatohepatitis: one-year results of the randomized placebo-controlled Fatty Liver Improvement with Rosiglitazone Therapy (FLIRT) Trial
    Vlad Ratziu
    Universite Pierre et Marie Curie Paris VI, Assistance Publique Hopitaux de Paris, Service d Hepatogastroenterologie, Paris, France
    Gastroenterology 135:100-10. 2008
    ..Nonalcoholic steatohepatitis (NASH) is a liver disease that complicates insulin-resistant states. This trial tested the efficacy and safety of rosiglitazone, an insulin-sensitizing agent, in patients with NASH...
  80. ncbi request reprint Evaluation of kryptor cardiac troponin I immunoassay
    Guillaume Lefevre
    Service de Biochimie et Hormonologie Hĵpital Tenon, Paris, France
    Ann Clin Biochem 39:145-7. 2002
    ..A fully automated, random access, fluorescent immunoassay for cTnl was evaluated in comparison with an established assay (Stratus cTnl) using samples from healthy subjects and from patients with cardiac disease...
  81. ncbi request reprint Patterns of proteinuria: urinary sodium dodecyl sulfate electrophoresis versus immunonephelometric protein marker measurement followed by interpretation with the knowledge-based system MDI-LabLink
    Mustapha Maachi
    INSERM Research Unit 402, Faculty of Medicine Saint Antoine, University Pierre and Marie Curie, Paris, France
    Clin Chem 50:1834-7. 2004
  82. ncbi request reprint Evaluation of the quantitative analytical methods real-time PCR for HER-2 gene quantification and ELISA of serum HER-2 protein and comparison with fluorescence in situ hybridization and immunohistochemistry for determining HER-2 status in breast cancer pa
    Chantal Tse
    Laboratoire de Biochimie, Hopital Tenon, Paris, France
    Clin Chem 51:1093-101. 2005
    ....
  83. ncbi request reprint Adipose tissue IL-6 content correlates with resistance to insulin activation of glucose uptake both in vivo and in vitro
    Jean Philippe Bastard
    Service de Biochimie et Hormonologie, Hôpital Tenon Rothschild, Assistance Publique Hopitaux de Paris AP HP, 75020 Paris, France
    J Clin Endocrinol Metab 87:2084-9. 2002
    ..In conclusion, increased IL-6 production by sc adipose cells might participate to the insulin-resistant state observed in human obesity...
  84. ncbi request reprint Expression of lamin A mutated in the carboxyl-terminal tail generates an aberrant nuclear phenotype similar to that observed in cells from patients with Dunnigan-type partial lipodystrophy and Emery-Dreifuss muscular dystrophy
    Catherine Favreau
    Departement de Biologie Cellulaire, Institut Jacques Monod, CNRS, Universités Paris 6 and 7, 75251, Paris Cedex 05, France
    Exp Cell Res 282:14-23. 2003
    ..Transfected cells therefore develop similar phenotypes when expressing lamins mutated in the carboxyl-terminal tail at sites responsible for FPLD or EDMD...
  85. ncbi request reprint Factors related to lipodystrophy and metabolic alterations in patients with human immunodeficiency virus infection receiving highly active antiretroviral therapy
    Marianne Saves
    Institut National de la Santé et de la Recherche Médicale INSERM Unité 330, Universite Victor Segalen Bordeaux, Bordeaux, France
    Clin Infect Dis 34:1396-405. 2002
    ..Detection and management of these disorders should be implemented to prevent further complications...
  86. ncbi request reprint Point-counterpoint: Interleukin-6 does/does not have a beneficial role in insulin sensitivity and glucose homeostasis
    Jean Philippe Bastard
    J Appl Physiol 102:821-2; author reply 825. 2007
  87. ncbi request reprint Uridine abrogates the adverse effects of antiretroviral pyrimidine analogues on adipose cell functions
    Ulrich A Walker
    Medizinische Universitatsklinik, Department of Rheumatology and Clinical Immunology, Freiburg, Germany
    Antivir Ther 11:25-34. 2006
    ..We assessed whether uridine can abrogate the adverse effects of NRTIs on adipocyte functions...
  88. ncbi request reprint Statins in HIV-associated lipodystrophy and metabolic syndrome: is there a missing link?
    Shahin Gharakhanian
    AIDS 20:1061-3. 2006
  89. ncbi request reprint A-type lamin-linked lipodystrophies
    Corinne Vigouroux
    INSERM U 402, Faculty of Medicine Saint Antoine and Department of Biochemistry, Tenon Hospital, Pierre and Marie Curie University, 27 rue Chaligny, 75571 Paris, France
    Novartis Found Symp 264:166-77; discussion 177-82, 227-30. 2005
    ....
  90. ncbi request reprint Association of apolipoproteins C3 and E with metabolic changes in HIV-infected adults treated with a protease-inhibitor-containing antiretroviral therapy
    Jean Marie Bard
    Faculte de Pharmacie, Laboratoire de Biochimie, Nantes, France
    Antivir Ther 11:361-70. 2006
    ....
  91. ncbi request reprint Effect of pioglitazone on HIV-1-related lipodystrophy: a randomized double-blind placebo-controlled trial (ANRS 113)
    Laurence Slama
    Department of Infectious and Tropical Diseases, Tenon Hospital, Paris, F 75020 France
    Antivir Ther 13:67-76. 2008
    ..Although thiazolidinediones have been shown to increase subcutaneous fat in congenital lipodystrophy, rosiglitazone did not show convincing results in HIV lipoatrophy. We assess a potential specific effect of pioglitazone in this setting...
  92. doi request reprint Association of a homozygous nonsense caveolin-1 mutation with Berardinelli-Seip congenital lipodystrophy
    C A Kim
    Department of Pediatrics, Instituto da Criança, University of Sao Paulo, 05403 900 Sao Paulo, Brazil
    J Clin Endocrinol Metab 93:1129-34. 2008
    ..In most reported cases, BSCL is due to alterations in either seipin, of unknown function, or 1-acylglycerol-3-phosphate acyltransferase-beta (AGPAT2), which catalyzes the formation of phosphatidic acid...
  93. ncbi request reprint Molecular analysis of Berardinelli-Seip congenital lipodystrophy in Oman: evidence for multiple loci
    Kirsten Heathcote
    Medical Genetics Unit, Department of Child Health, St George s Hospital Medical School, London, UK
    Diabetes 51:1291-3. 2002
    ..However, two sibships (four subjects) did not map to either locus, raising the possibility of more than two lipodystrophy loci within the Oman population...