J Capeau

Summary

Country: France

Publications

  1. ncbi [Premature aging in human immunodeficiency virus (HIV) infected patients: detection, pathophysiological mechanisms and management]
    Jacqueline Capeau
    Biochimie et hormonologie, Hôpital Tenon AP HP Paris, CdR Saint Antoine, Inserm U938, Université Paris6 UPMC, Faculte de Medecine Pierre et Marie Curie, 27 rue Chaligny, 75571 Paris Cedex 12, France
    Bull Acad Natl Med 195:2013-22; discussion 2022-4. 2011
  2. doi Ten-year diabetes incidence in 1046 HIV-infected patients started on a combination antiretroviral treatment
    Jacqueline Capeau
    UPMC Univ Paris, UMR_S, INSERM, CdR Saint Antoine, AP HP, Hopital Tenon, France
    AIDS 26:303-14. 2012
  3. doi Human lipodystrophies: genetic and acquired diseases of adipose tissue
    Jacqueline Capeau
    INSERM, U938, CdR Saint Antoine, Paris, France
    Endocr Dev 19:1-20. 2010
  4. doi Insulin resistance and steatosis in humans
    J Capeau
    Univ Paris 6, Inserm UMR_S893 Equipe 9, Faculte de Medecine Pierre et Marie Curie, 75571 Paris Cedex 12, France
    Diabetes Metab 34:649-57. 2008
  5. ncbi Survival and functions of encapsulated porcine hepatocytes after allotransplantation or xenotransplantation without immunosuppression
    S Benoist
    Research Unit 402 of INSERM, Paris, France
    Surgery 129:606-16. 2001
  6. ncbi The HIV protease inhibitor indinavir impairs sterol regulatory element-binding protein-1 intranuclear localization, inhibits preadipocyte differentiation, and induces insulin resistance
    M Caron
    Institut National de la Santé et de la Recherche Médicale INSERM U 402, Faculte de Medecine Saint Antoine, 27, rue Chaligny, 75571 Paris Cedex 12, France
    Diabetes 50:1378-88. 2001
  7. ncbi Insulin-mediated cell proliferation and survival involve inhibition of c-Jun N-terminal kinases through a phosphatidylinositol 3-kinase- and mitogen-activated protein kinase phosphatase-1-dependent pathway
    C Desbois-Mouthon
    INSERM U 402, Faculte de Medecine Saint Antoine, Paris, France
    Endocrinology 141:922-31. 2000
  8. ncbi Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss
    J P Bastard
    Service de Biochimie, Hopital de la Salpetriere, Paris, France
    J Clin Endocrinol Metab 85:3338-42. 2000
  9. ncbi Enterocytic differentiation of the human Caco-2 cell line correlates with alterations in integrin signaling
    P Levy
    INSERM U 402, Faculte de Medecine Saint Antoine, Paris, France
    J Cell Physiol 177:618-27. 1998
  10. ncbi Survival and differentiation of porcine hepatocytes encapsulated by semiautomatic device and allotransplanted in large number without immunosuppression
    S Benoist
    Research Unit 402, INSERM, Hospital Saint-Antoine, Paris, France
    J Hepatol 35:208-16. 2001

Detail Information

Publications38

  1. ncbi [Premature aging in human immunodeficiency virus (HIV) infected patients: detection, pathophysiological mechanisms and management]
    Jacqueline Capeau
    Biochimie et hormonologie, Hôpital Tenon AP HP Paris, CdR Saint Antoine, Inserm U938, Université Paris6 UPMC, Faculte de Medecine Pierre et Marie Curie, 27 rue Chaligny, 75571 Paris Cedex 12, France
    Bull Acad Natl Med 195:2013-22; discussion 2022-4. 2011
    ..Management of these patients involves lifestyle modifications and switching from first-generation antiretrovirals towards less toxic drugs. Antiinflammatory treatment could be considered for at-risk patients...
  2. doi Ten-year diabetes incidence in 1046 HIV-infected patients started on a combination antiretroviral treatment
    Jacqueline Capeau
    UPMC Univ Paris, UMR_S, INSERM, CdR Saint Antoine, AP HP, Hopital Tenon, France
    AIDS 26:303-14. 2012
    ..To evaluate the incidence and determinants of diabetes in a cohort of HIV-infected adults initiated with combination antiretroviral treatment (cART) in 1997-1999 and followed up to 2009...
  3. doi Human lipodystrophies: genetic and acquired diseases of adipose tissue
    Jacqueline Capeau
    INSERM, U938, CdR Saint Antoine, Paris, France
    Endocr Dev 19:1-20. 2010
    ..Treatment of fat redistribution can sometimes benefit from plastic surgery. Lipid and glucose alterations are difficult to control leading to early occurrence of diabetic, cardiovascular and hepatic complications...
  4. doi Insulin resistance and steatosis in humans
    J Capeau
    Univ Paris 6, Inserm UMR_S893 Equipe 9, Faculte de Medecine Pierre et Marie Curie, 75571 Paris Cedex 12, France
    Diabetes Metab 34:649-57. 2008
    ....
  5. ncbi Survival and functions of encapsulated porcine hepatocytes after allotransplantation or xenotransplantation without immunosuppression
    S Benoist
    Research Unit 402 of INSERM, Paris, France
    Surgery 129:606-16. 2001
    ..The demonstration of maintained hepatic functions in transplanted porcine hepatocytes up to 15 days is a first step toward application in the treatment of acute liver failure...
  6. ncbi The HIV protease inhibitor indinavir impairs sterol regulatory element-binding protein-1 intranuclear localization, inhibits preadipocyte differentiation, and induces insulin resistance
    M Caron
    Institut National de la Santé et de la Recherche Médicale INSERM U 402, Faculte de Medecine Saint Antoine, 27, rue Chaligny, 75571 Paris Cedex 12, France
    Diabetes 50:1378-88. 2001
    ..Hence, indinavir impairs differentiation at an early step of adipose conversion probably involving the process controlling SREBP-1 intranuclear localization...
  7. ncbi Insulin-mediated cell proliferation and survival involve inhibition of c-Jun N-terminal kinases through a phosphatidylinositol 3-kinase- and mitogen-activated protein kinase phosphatase-1-dependent pathway
    C Desbois-Mouthon
    INSERM U 402, Faculte de Medecine Saint Antoine, Paris, France
    Endocrinology 141:922-31. 2000
    ..Altogether, these results demonstrate that insulin inhibits JNKs through a PI 3-K- and MKP-1-dependent pathway and provide evidence for a key role for JNK inhibition in insulin regulation of proliferation and survival...
  8. ncbi Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss
    J P Bastard
    Service de Biochimie, Hopital de la Salpetriere, Paris, France
    J Clin Endocrinol Metab 85:3338-42. 2000
    ..The reduced production and serum concentrations after weight loss could play a role in the improved sensitivity to insulin observed in these patients...
  9. ncbi Enterocytic differentiation of the human Caco-2 cell line correlates with alterations in integrin signaling
    P Levy
    INSERM U 402, Faculte de Medecine Saint Antoine, Paris, France
    J Cell Physiol 177:618-27. 1998
    ....
  10. ncbi Survival and differentiation of porcine hepatocytes encapsulated by semiautomatic device and allotransplanted in large number without immunosuppression
    S Benoist
    Research Unit 402, INSERM, Hospital Saint-Antoine, Paris, France
    J Hepatol 35:208-16. 2001
    ..CONCLUSIONS: The preservation of hepatocyte functions during 1-2 weeks is encouraging for potential short-term use of such bioartificial liver in future clinical application...
  11. ncbi Long-term treatment with interleukin-1beta induces insulin resistance in murine and human adipocytes
    C Lagathu
    INSERM, U680, Université Pierre et Marie Curie UPMC Paris 6, Faculty of Medicine, 27 rue Chaligny, 75012, Paris, France
    Diabetologia 49:2162-73. 2006
    ..Adipose tissue inflammation has recently been implicated in the pathogenesis of insulin resistance and is probably linked to high local levels of cytokines. IL1B, a proinflammatory cytokine, may participate in this alteration...
  12. ncbi A new missense mutation in the calcium-sensing receptor in familial benign hypercalcaemia associated with partial lipoatrophy and insulin resistant diabetes
    C Vigouroux
    INSERM U402, Faculte de Medecine Saint Antoine, Paris, France
    Clin Endocrinol (Oxf) 53:393-8. 2000
    ..1998). This mutation is therefore likely to be responsible of the FBHH phenotype. A pathophysiological link between this mutation and insulin resistance remains unclear...
  13. ncbi [Primary lipodystrophies]
    J Capeau
    INSERM, U680, 75012 Paris, France
    Ann Endocrinol (Paris) 68:10-20. 2007
    ..The prognosis is linked to the precocity and severity of the diabetic, cardiovascular and liver complications...
  14. ncbi Human lipodystrophies linked to mutations in A-type lamins and to HIV protease inhibitor therapy are both associated with prelamin A accumulation, oxidative stress and premature cellular senescence
    M Caron
    INSERM U680, Universite Pierre et Marie Curie Paris 6, Faculte de Medecine, site Saint Antoine, 27 rue Chaligny, 75571 Paris Cedex 12, France
    Cell Death Differ 14:1759-67. 2007
    ..These alterations could participate in the pathophysiology of lipodystrophic syndromes and lead to premature ageing complications...
  15. ncbi Adverse metabolic disorders during highly active antiretroviral treatments (HAART) of HIV disease
    C Vigouroux
    Service de Biochimie, Hopital Rothschild, Paris, France
    Diabetes Metab 25:383-92. 1999
    ..Studies are in progress to evaluate the possibility of therapeutic alternatives to PI when major metabolic disturbances are present...
  16. ncbi Deletion of Asn281 in the alpha-subunit of the human insulin receptor causes constitutive activation of the receptor and insulin desensitization
    C Desbois-Mouthon
    INSERM U 402, Paris, France
    J Clin Endocrinol Metab 81:719-27. 1996
    ..These findings strongly suggest that Asn281 of the IR alpha-subunit plays a critical role in the inhibitory constraint exerted by the extracellular alpha-subunit over the intracellular kinase activity...
  17. ncbi Diseases of adipose tissue: genetic and acquired lipodystrophies
    J Capeau
    INSERM U680, Saint Antoine Faculty of Medicine, Université Pierre et Marie Curie UPMC, Paris, France
    Biochem Soc Trans 33:1073-7. 2005
    ..Such syndromes help to understand the mechanisms involved in insulin resistance resulting from altered fat repartition and could benefit from insulin-sensitizing effects of lifestyle modifications or of specific medications...
  18. doi Metabolic disorders and chronic viral disease: the case of HIV and HCV
    L Slama
    Service des Maladies Infectieuses, Hopital Tenon, AP HP, 4, rue de la Chine, 75970 Paris Cedex 20, France
    Diabetes Metab 35:1-11. 2009
    ..Recent data indicate that HCV clearance improves insulin resistance and hepatic function in HCV-infected patients treated with interferon with or without ribavirin...
  19. ncbi [Major insulin resistance syndromes: clinical and physiopathological aspects]
    C Vigouroux
    Unité INSERM 402, Faculte de Medecine Saint Antoine, 27, rue Chaligny, 75571 Paris
    J Soc Biol 195:249-57. 2001
    ....
  20. ncbi Molecular analysis of the insulin receptor gene for prenatal diagnosis of leprechaunism in two families
    C Desbois-Mouthon
    Unité INSERM 402, Faculte de Medecine Saint Antoine, Paris, France
    Prenat Diagn 17:657-63. 1997
    ..This methodology allowed us to correctly predict the genotype of the two fetuses at the IR locus...
  21. ncbi Etiological investigations in apparent type 2 diabetes: when to search for lamin A/C mutations?
    B Donadille
    INSERM U680, Pierre and Marie Curie Faculty of Medicine, site Saint Antoine, 27 rue de Chaligny, 75571 Paris Cedex 12, France
    Diabetes Metab 31:527-32. 2005
    ..In addition, the molecular screening of family members allows an earlier efficient clinical management of affected relatives...
  22. pmc Syndecan-1 alterations during the tumorigenic progression of human colonic Caco-2 cells induced by human Ha-ras or polyoma middle T oncogenes
    P Levy
    Laboratoire de Biologie Cellulaire, INSERM U 402, , Paris, France
    Br J Cancer 74:423-31. 1996
    ....
  23. doi How can we measure insulin sensitivity/resistance?
    B Antuna-Puente
    Unité mixte de recherche S938, Centre de Recherche Saint Antoine, Institut National de la Sante et de la Recherche Medicale, Universite Pierre et Marie Curie Paris 6, 27, rue Chaligny, 75571 Paris Cedex 12, France
    Diabetes Metab 37:179-88. 2011
    ..The aim of this review is to analyze the most frequently used assay methods in an attempt to evaluate when and why these methods may be useful...
  24. ncbi Insulin action is mimicked by polyclonal antireceptor antibodies that activate the insulin receptor tyrosine kinase
    M Caron
    Laboratoire de Biochimie, INSERM U181, , Paris, France
    Horm Metab Res 21:295-300. 1989
    ..Taken together, these results are consistent with a role for the kinase activity of the insulin receptor in mediating the action of insulin...
  25. ncbi Insulin and IGF-1 stimulate the beta-catenin pathway through two signalling cascades involving GSK-3beta inhibition and Ras activation
    C Desbois-Mouthon
    INSERM U.402, , Paris, France
    Oncogene 20:252-9. 2001
    ..These findings demonstrate for the first time the ability of insulin and IGF-1 to activate the beta-catenin pathway in hepatoma cells and thereby provide new insights into the role of these factors in hepatocarcinogenesis...
  26. ncbi Gene transfer by adenovirus-mimetic peptides in the presence of a cationic lipid and/or adenovirus. Analysis of the contribution of the viral and nonviral components
    S Moritz
    INSERM U402, Faculte de Medecine Saint Antoine, Paris, France
    Arch Virol 148:1-18. 2003
    ....
  27. doi Diagnostic value of procalcitonin in acutely hospitalized elderly patients
    O Steichen
    Unité de gériatrie, Service de Medecine Interne, AP HP, Hopital Tenon, 4 rue de la Chine, 75020 Paris, France
    Eur J Clin Microbiol Infect Dis 28:1471-6. 2009
    ..Despite a good overall diagnostic accuracy, the clinical usefulness of PCT to diagnose invasive bacterial infections in elderly patients hospitalized in an acute geriatric ward appears to be very limited...
  28. ncbi Cytoskeletal association of the A and B nucleoside diphosphate kinases of interphasic but not mitotic human carcinoma cell lines: specific nuclear localization of the B subunit
    V P Pinon
    INSERM U402, CHU Saint Antoine, Paris, France
    Exp Cell Res 246:355-67. 1999
    ..Their altered localization in dividing cells suggests colocalization with yet unidentified structures which are not intermediate filament aggregates...
  29. ncbi A new human nm23 homologue (nm23-H5) specifically expressed in testis germinal cells
    A Munier
    INSERM U402, Faculte de Medecine Saint Antoine, Paris, France
    FEBS Lett 434:289-94. 1998
    ..However, under usual assay conditions, Nm23-H5 expressed in Escherichia coli did not exhibit NDP kinase activity. These results suggest that Nm23-H5 is specifically involved in early stages of spermatogenesis...
  30. ncbi Glycoconjugate metabolism in a cystic fibrosis knockout mouse model
    C Mailleau
    Institut National de la Santé et de la Recherche Médicale U 402, Faculte de Medecine Saint Antoine, University Paris VI, Paris, France
    Mol Genet Metab 72:122-31. 2001
    ....
  31. ncbi [Factors associated with hyperhomocysteinemia in Crohn's disease]
    F Maire
    Service d Hepato Gastroenterologie, Hopital Rothschild, Paris, France
    Gastroenterol Clin Biol 25:745-8. 2001
    ..The aims were: 1) to assess the prevalence of hyperhomocysteinemia in a large series of patients with Crohn's disease; 2) to search for clinical and biological factors associated with hyperhomocysteinemia...
  32. ncbi Systemic low-grade inflammation is related to both circulating and adipose tissue TNFalpha, leptin and IL-6 levels in obese women
    M Maachi
    Service de Biochimie et Hormonologie, Hopital Tenon, AP HP, France
    Int J Obes Relat Metab Disord 28:993-7. 2004
    ..We assessed the relationships between four circulating acute phase proteins and the circulating and adipose tissue levels of three adipocytokines...
  33. ncbi Identification of the gene altered in Berardinelli-Seip congenital lipodystrophy on chromosome 11q13
    J Magre
    INSERM U 402, Faculte de Medecine Saint Antoine, Universite Pierre et Marie Curie, 27 rue Chaligny, 75012 Paris, France
    Nat Genet 28:365-70. 2001
    ..These findings are of general importance for understanding the molecular mechanisms underlying regulation of body fat distribution and insulin resistance...
  34. ncbi Semiautomatic macroencapsulation of fresh or cryopreserved porcine hepatocytes maintain their ability for treatment of acute liver failure
    R Sarkis
    Research Unit 402, INSERM, Paris, France
    Cell Transplant 10:601-7. 2001
    ..Cryopreserved cells were as efficient as fresh hepatocytes...
  35. ncbi Bile acid transport and regulating functions in the human biliary epithelium
    N Chignard
    , , , , Paris, France
    Hepatology 33:496-503. 2001
    ..The differential effect of TUDC may cause a reduction in bile inspissation and provide a benefit in biliary disorders...
  36. ncbi The nuclear pore complex is involved in nuclear transfer of plasmid DNA condensed with an oligolysine-RGD peptide containing nuclear localisation properties
    M Colin
    INSERM U402, , Paris, France
    Gene Ther 8:1643-53. 2001
    ..We propose that the oligolysine-RGD peptide acts as a nuclear localisation signal and that the cationic lipid is more important for cell entry and endosome destabilisation than nuclear transfer...
  37. ncbi nm23-H4, a new member of the family of human nm23/nucleoside diphosphate kinase genes localised on chromosome 16p13
    L Milon
    INSERM U 402, Faculte de Medecine Saint Antoine, Paris, France
    Hum Genet 99:550-7. 1997
    ..Nm23-H4 naturally possesses the Pro-Ser substitution equivalent to the K-pn mutation (P97S) of Drosophila...
  38. ncbi Differences in both glycosylation and binding properties between rat and mouse liver prolactin receptors
    O Lascols
    Laboratorie de Biologie Cellulaire, I N S E R M U402, Faculte de Medecine Saint Antoine, Paris, France
    Cell Mol Biol (Noisy-le-grand) 40:359-71. 1994
    ....