Thomas Candela

Summary

Country: France

Publications

  1. doi request reprint Cell-wall preparation containing poly-γ-D-glutamate covalently linked to peptidoglycan, a straightforward extractable molecule, protects mice against experimental anthrax infection
    Thomas Candela
    Institut Pasteur, Toxines et Pathogénie Bactériennes, 25 rue du Dr Roux, 75015 Paris, France
    Vaccine 31:171-5. 2012
  2. pmc Identification of the Bacillus anthracis (gamma) phage receptor
    Sophie Davison
    Toxines et Pathogénie Bactérienne, Institut Pasteur, 28 rue du Dr Roux, Cedex 15, Paris 75724, France
    J Bacteriol 187:6742-9. 2005
  3. doi request reprint Fusobacterium nucleatum, the first Gram-negative bacterium demonstrated to produce polyglutamate
    Thomas Candela
    Institut Pasteur, Toxines et Pathogénie Bactérienne, CNRS, URA 2172, 25 rue du Dr Roux, Paris Cedex 15, France
    Can J Microbiol 55:627-32. 2009
  4. pmc CapE, a 47-amino-acid peptide, is necessary for Bacillus anthracis polyglutamate capsule synthesis
    Thomas Candela
    Toxines et Pathogénie Bactérienne, Institut Pasteur, Paris, France
    J Bacteriol 187:7765-72. 2005
  5. ncbi request reprint Encapsulated Bacillus anthracis interacts closely with liver endothelium
    Alejandro Piris-Gimenez
    Institut Pasteur, Unité Toxines et Pathogénie Bactériennes, Paris, France
    J Infect Dis 200:1381-9. 2009
  6. ncbi request reprint Poly-gamma-glutamate in bacteria
    Thomas Candela
    Unité Toxines et Pathogénie Bactérienne CNRS, URA 2172, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Mol Microbiol 60:1091-8. 2006
  7. pmc Edema toxin impairs anthracidal phospholipase A2 expression by alveolar macrophages
    Benoit Raymond
    Institut Pasteur, Unité de Défense Innée et Inflammation, Paris, France
    PLoS Pathog 3:e187. 2007
  8. ncbi request reprint Genetic analysis of Bacillus anthracis Sap S-layer protein crystallization domain
    Thomas Candela
    Unité Toxines et Pathogénie Bactérienne CNRS, URA 2172, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Microbiology 151:1485-90. 2005

Collaborators

Detail Information

Publications8

  1. doi request reprint Cell-wall preparation containing poly-γ-D-glutamate covalently linked to peptidoglycan, a straightforward extractable molecule, protects mice against experimental anthrax infection
    Thomas Candela
    Institut Pasteur, Toxines et Pathogénie Bactériennes, 25 rue du Dr Roux, 75015 Paris, France
    Vaccine 31:171-5. 2012
    ..When combined to protective antigen, GluPG immunization conferred full protection against cutaneous anthrax induced with a fully virulent strain...
  2. pmc Identification of the Bacillus anthracis (gamma) phage receptor
    Sophie Davison
    Toxines et Pathogénie Bactérienne, Institut Pasteur, 28 rue du Dr Roux, Cedex 15, Paris 75724, France
    J Bacteriol 187:6742-9. 2005
    ..B. thuringiensis 97-27, a strain which, by sequence analysis, is predicted to harbor a GamR-like protein, is resistant to the phage but nevertheless displays phage binding...
  3. doi request reprint Fusobacterium nucleatum, the first Gram-negative bacterium demonstrated to produce polyglutamate
    Thomas Candela
    Institut Pasteur, Toxines et Pathogénie Bactérienne, CNRS, URA 2172, 25 rue du Dr Roux, Paris Cedex 15, France
    Can J Microbiol 55:627-32. 2009
    ..It is suggested that, like for Gram-positive bacteria, poly-gamma-glutamate has a role in virulence for pathogens and one in survival for other Gram-negative bacteria...
  4. pmc CapE, a 47-amino-acid peptide, is necessary for Bacillus anthracis polyglutamate capsule synthesis
    Thomas Candela
    Toxines et Pathogénie Bactérienne, Institut Pasteur, Paris, France
    J Bacteriol 187:7765-72. 2005
    ..All the bacterial polyglutamate synthesis systems analyzed show a similar genetic organization and, we suggest, the same protein requirements...
  5. ncbi request reprint Encapsulated Bacillus anthracis interacts closely with liver endothelium
    Alejandro Piris-Gimenez
    Institut Pasteur, Unité Toxines et Pathogénie Bactériennes, Paris, France
    J Infect Dis 200:1381-9. 2009
    ..The Bacillus anthracis poly-gamma-D-glutamate capsule is essential for virulence. It impedes phagocytosis and protects bacilli from the immune system, thus promoting systemic dissemination...
  6. ncbi request reprint Poly-gamma-glutamate in bacteria
    Thomas Candela
    Unité Toxines et Pathogénie Bactérienne CNRS, URA 2172, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Mol Microbiol 60:1091-8. 2006
    ..The anchoring of PGA to the bacterial surface is important for virulence. All cap genes are therefore potential targets for inhibitors specifically blocking PGA synthesis or anchorage...
  7. pmc Edema toxin impairs anthracidal phospholipase A2 expression by alveolar macrophages
    Benoit Raymond
    Institut Pasteur, Unité de Défense Innée et Inflammation, Paris, France
    PLoS Pathog 3:e187. 2007
    ..Our study, therefore, describes a new molecular mechanism implemented by B. anthracis to escape innate host defense. These pioneering data will provide new molecular targets for future intervention against this deadly pathogen...
  8. ncbi request reprint Genetic analysis of Bacillus anthracis Sap S-layer protein crystallization domain
    Thomas Candela
    Unité Toxines et Pathogénie Bactérienne CNRS, URA 2172, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Microbiology 151:1485-90. 2005
    ..It was noteworthy that only one polypeptide, which spanned aa 148-358, was able to interact with less than the complete Sap c, in fact, with itself...