Isabelle Callebaut

Summary

Country: France

Publications

  1. ncbi request reprint Cernunnos interacts with the XRCC4 x DNA-ligase IV complex and is homologous to the yeast nonhomologous end-joining factor Nej1
    Isabelle Callebaut
    Département de Biologie Structurale, Institut de Minéralogie et de Physique des Milieux Condensés, CNRS UMR7590, Universités Paris 6 et Paris 7, Paris, F 75005 France
    J Biol Chem 281:13857-60. 2006
  2. doi request reprint Calcineurin B-like domains in the large regulatory alpha/beta subunits of phosphorylase kinase
    Cathelène Carrière
    Département de Biologie Structurale, Institut de Minéralogie et de Physique des Milieux Condensés, UMR 7590, CNRS, Universités Paris 6 et Paris 7, Paris, France
    Proteins 71:1597-606. 2008
  3. ncbi request reprint Isolated ZP-N domains constitute the N-terminal extensions of Zona Pellucida proteins
    Isabelle Callebaut
    Département de Biologie Structurale, IMPMC UMR 7590, Universités Pierre et Marie Curie Paris6, Paris, France
    Bioinformatics 23:1871-4. 2007
  4. pmc Prediction of the general transcription factors associated with RNA polymerase II in Plasmodium falciparum: conserved features and differences relative to other eukaryotes
    Isabelle Callebaut
    Centre National de la Recherche Scientifique CNRS UMR7590, Universités Paris 6 et Paris 7, Département de Biologie Structurale, IMPMC, 75252 Paris Cedex 05, France
    BMC Genomics 6:100. 2005
  5. ncbi request reprint OCRE: a novel domain made of imperfect, aromatic-rich octamer repeats
    Isabelle Callebaut
    Département de Biologie Structurale, LMCP, CNRS UMR7590, Universités Paris 6 and Paris 7, case 115, 4 place Jussieu, 75252 Paris Cedex 05, France Isabelle
    Bioinformatics 21:699-702. 2005
  6. pmc A generalized analysis of hydrophobic and loop clusters within globular protein sequences
    Richard Eudes
    Structural Biology Department, IMPMC, CNRS UMR7590, Universités Paris 6 and Paris 7, case 115, 4 place Jussieu, 75252 Paris Cedex 05, France
    BMC Struct Biol 7:2. 2007
  7. pmc Metallo-beta-lactamase fold within nucleic acids processing enzymes: the beta-CASP family
    Isabelle Callebaut
    Systèmes moléculaires et Biologie structurale, LMCP, CNRS UMR 7590, Universités Paris 6 et Paris 7, case 115, 4 place Jussieu, F 75252 Paris Cedex 05, France
    Nucleic Acids Res 30:3592-601. 2002
  8. doi request reprint Molecular models of the open and closed states of the whole human CFTR protein
    Jean Paul Mornon
    IMPMC, UMR7590, CNRS, Universités Pierre et Marie Curie Paris 6 et Denis Diderot Paris 7, 140 rue de Lourmel, Paris, France
    Cell Mol Life Sci 66:3469-86. 2009
  9. ncbi request reprint An EVH1/WH1 domain as a key actor in TGFbeta signalling
    Isabelle Callebaut
    Systèmes moléculaires and Biologie structurale, LMCP, CNRS UMR 7590, Universités Paris 6 and Paris 7, case 115, 4 place Jussieu, Paris, France
    FEBS Lett 519:178-80. 2002
  10. ncbi request reprint Sequence-based modeling of Abeta42 soluble oligomers
    Fabienne Dulin
    Département de Biologie Structurale, IMPMC, CNRS UMR7590, Universités Pierre et Marie Curie Paris 6 et Denis Diderot Paris 7, F 75005 France
    Biopolymers 85:422-37. 2007

Collaborators

Detail Information

Publications59

  1. ncbi request reprint Cernunnos interacts with the XRCC4 x DNA-ligase IV complex and is homologous to the yeast nonhomologous end-joining factor Nej1
    Isabelle Callebaut
    Département de Biologie Structurale, Institut de Minéralogie et de Physique des Milieux Condensés, CNRS UMR7590, Universités Paris 6 et Paris 7, Paris, F 75005 France
    J Biol Chem 281:13857-60. 2006
    ..Altogether these results shed new lights on the last step, the DNA religation, of the NHEJ pathway...
  2. doi request reprint Calcineurin B-like domains in the large regulatory alpha/beta subunits of phosphorylase kinase
    Cathelène Carrière
    Département de Biologie Structurale, Institut de Minéralogie et de Physique des Milieux Condensés, UMR 7590, CNRS, Universités Paris 6 et Paris 7, Paris, France
    Proteins 71:1597-606. 2008
    ..This finding, together the identification of significant similarities of domain D with the preceding domain C, may help to understand the molecular mechanism by which PhK alpha and/or beta domain D might regulate PhK activity...
  3. ncbi request reprint Isolated ZP-N domains constitute the N-terminal extensions of Zona Pellucida proteins
    Isabelle Callebaut
    Département de Biologie Structurale, IMPMC UMR 7590, Universités Pierre et Marie Curie Paris6, Paris, France
    Bioinformatics 23:1871-4. 2007
    ....
  4. pmc Prediction of the general transcription factors associated with RNA polymerase II in Plasmodium falciparum: conserved features and differences relative to other eukaryotes
    Isabelle Callebaut
    Centre National de la Recherche Scientifique CNRS UMR7590, Universités Paris 6 et Paris 7, Département de Biologie Structurale, IMPMC, 75252 Paris Cedex 05, France
    BMC Genomics 6:100. 2005
    ..In this study, we have used a combination of sensitive sequence analysis methods to predict the existence of several parasite encoded general transcription factors associated with RNA polymerase II...
  5. ncbi request reprint OCRE: a novel domain made of imperfect, aromatic-rich octamer repeats
    Isabelle Callebaut
    Département de Biologie Structurale, LMCP, CNRS UMR7590, Universités Paris 6 and Paris 7, case 115, 4 place Jussieu, 75252 Paris Cedex 05, France Isabelle
    Bioinformatics 21:699-702. 2005
    ....
  6. pmc A generalized analysis of hydrophobic and loop clusters within globular protein sequences
    Richard Eudes
    Structural Biology Department, IMPMC, CNRS UMR7590, Universités Paris 6 and Paris 7, case 115, 4 place Jussieu, 75252 Paris Cedex 05, France
    BMC Struct Biol 7:2. 2007
    ..These species are characterized only by their hydrophobic/non-hydrophobic dichotomy. This analysis has been extended to loop-forming clusters, using an appropriate loop alphabet...
  7. pmc Metallo-beta-lactamase fold within nucleic acids processing enzymes: the beta-CASP family
    Isabelle Callebaut
    Systèmes moléculaires et Biologie structurale, LMCP, CNRS UMR 7590, Universités Paris 6 et Paris 7, case 115, 4 place Jussieu, F 75252 Paris Cedex 05, France
    Nucleic Acids Res 30:3592-601. 2002
    ....
  8. doi request reprint Molecular models of the open and closed states of the whole human CFTR protein
    Jean Paul Mornon
    IMPMC, UMR7590, CNRS, Universités Pierre et Marie Curie Paris 6 et Denis Diderot Paris 7, 140 rue de Lourmel, Paris, France
    Cell Mol Life Sci 66:3469-86. 2009
    ....
  9. ncbi request reprint An EVH1/WH1 domain as a key actor in TGFbeta signalling
    Isabelle Callebaut
    Systèmes moléculaires and Biologie structurale, LMCP, CNRS UMR 7590, Universités Paris 6 and Paris 7, case 115, 4 place Jussieu, Paris, France
    FEBS Lett 519:178-80. 2002
    ..This finding highlights the pivotal role that the EVH1/WH1 family of domains play in multiple eukaryotic signal transduction pathways...
  10. ncbi request reprint Sequence-based modeling of Abeta42 soluble oligomers
    Fabienne Dulin
    Département de Biologie Structurale, IMPMC, CNRS UMR7590, Universités Pierre et Marie Curie Paris 6 et Denis Diderot Paris 7, F 75005 France
    Biopolymers 85:422-37. 2007
    ..The consistency of these models is discussed with respect to available experimental and theoretical data...
  11. ncbi request reprint Characterization and study of a kappa-casein-like chymosin-sensitive linkage
    Isabelle Callebaut
    Département de Biologie Structurale, IMPMC, CNRS UMR7590, Universités Paris 6 et Paris 7, case 115, 4 place Jussieu, 75252 Paris Cedex 05, France
    Biochim Biophys Acta 1749:75-80. 2005
    ..The effect of the enzyme activity of chymosin was thus tested on glutamine synthetase. Chymosin cut the latter at the Phe-Met linkage, suggesting that this system may locally resemble the kappa-casein/chymosin complex...
  12. ncbi request reprint EMI domains are widespread and reveal the probable orthologs of the Caenorhabditis elegans CED-1 protein
    Isabelle Callebaut
    Systèmes moléculaires et Biologie structurale, LMCP, CNRS UMR7590, Universités Paris 6 et Paris 7, case 115, 4 place Jussieu, 75252 05 Paris Cedex, France
    Biochem Biophys Res Commun 300:619-23. 2003
    ..Sequence profiles specific of the EMI family of domains led to identify the probable orthologs of the C. elegans CED-1 protein in mammals and insects, which were yet uncovered...
  13. pmc Multiple pathways inhibit NHEJ at telomeres
    Stéphane Marcand
    Centre National de la Recherche Scientifque UMR 217, Institut de Radiobiologie Cellulaire et Moleculaire, CEA Fontenay, 92265 Fontenay aux Roses Cedex, France
    Genes Dev 22:1153-8. 2008
    ..We discuss a possible mechanism that would explain Rif2 multifunctionality at telomeres and the recent evolutionary origin of Rif2 from an origin recognition complex (ORC) subunit...
  14. pmc The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate
    Monica Dentice
    Thyroid Section, Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Nat Cell Biol 7:698-705. 2005
    ..Thus, ECS(WSB-1) mediates a mechanism by which 'systemic' thyroid hormone can effect local control of the Hedgehog-PTHrP negative feedback loop and thus skeletogenesis...
  15. pmc Identification of the hydrophobic strand in the A-B loop of leptin as major binding site III: implications for large-scale preparation of potent recombinant human and ovine leptin antagonists
    Leonora Niv-Spector
    Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University, Rehovot 76100, Israel
    Biochem J 391:221-30. 2005
    ....
  16. pmc Identification, characterization and metagenome analysis of oocyte-specific genes organized in clusters in the mouse genome
    Amélie Paillisson
    Physiologie de la Reproduction et des Comportements, UMR 6175 INRA CNRS Université François Rabelais de Tours Haras Nationaux, 37380 Nouzilly, France
    BMC Genomics 6:76. 2005
    ..In an attempt to identify novel oocyte-specific genes in the mouse, we have used an in silico subtraction methodology, and we have focused our attention on genes that are organized in genomic clusters...
  17. ncbi request reprint The yeast Sar exchange factor Sec12, and its higher organism orthologs, fold as beta-propellers
    Pierre Chardin
    FEBS Lett 525:171-3. 2002
  18. ncbi request reprint ATP hydrolysis is essential for the function of the Uup ATP-binding cassette ATPase in precise excision of transposons
    Dorothee Murat
    Unité des Membranes Bactériennes CNRS URA2172, Département de Microbiologie Fondamentale et Médicale, Site Fernbach, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France
    J Biol Chem 281:6850-9. 2006
    ..Analysis of Walker motif B mutants suggests that ATP hydrolysis at the two ABC domains is strictly coordinated and is essential for the function of Uup in vivo...
  19. pmc The checkpoint Saccharomyces cerevisiae Rad9 protein contains a tandem tudor domain that recognizes DNA
    Nathalie Lancelot
    Institut de Biologie et Technologies de Saclay, CEA Saclay, 91191 Gif sur Yvette, France
    Nucleic Acids Res 35:5898-912. 2007
    ..However, their modes of chromatin recognition are different, suggesting that the corresponding interactions are differently regulated...
  20. ncbi request reprint The glycine residues G551 and G1349 within the ATP-binding cassette signature motifs play critical roles in the activation and inhibition of cystic fibrosis transmembrane conductance regulator channels by phloxine B
    Patricia Melin
    Institut de Physiologie et Biologie Cellulaires, CNRS UMR6187, Universite de Poitiers, 40 Avenue du Recteur Pineau, 86022, Poitiers, France
    J Membr Biol 208:203-12. 2005
    ..These data show that G551 and G1349 control the inhibition and activation of CFTR by these agents, suggesting functional nonequivalence of the signature motifs of NBD in the ABC transporter CFTR...
  21. ncbi request reprint Structural and functional characterization of the TgDRE multidomain protein, a DNA repair enzyme from Toxoplasma gondii
    Karine Frénal
    Unité de Résonance Magnétique Nucléaire des Biomolécules, CNRS URA 2185, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Biochemistry 45:4867-74. 2006
    ..The presence of both RNA- and protein-binding domains seems to indicate that TgDRE could also be involved in RNA metabolism...
  22. pmc The discovery of SycO highlights a new function for type III secretion effector chaperones
    Michel Letzelter
    Biozentrum der Universitat Basel, Basel, Switzerland
    EMBO J 25:3223-33. 2006
    ..We propose that covering an MLD might be an essential function of T3S effector chaperones...
  23. pmc The thyroid hormone-inactivating deiodinase functions as a homodimer
    G D Vivek Sagar
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Endocrinol 22:1382-93. 2008
    ..In conclusion, the inactivating deiodinase D3 exists as homo- or heterodimer in living intact cells, a feature that is critical for their catalytic activities...
  24. pmc Ubiquitination-induced conformational change within the deiodinase dimer is a switch regulating enzyme activity
    G D Vivek Sagar
    Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell Biol 27:4774-83. 2007
    ..The continuous association of D2 with this regulatory protein complex supports rapid cycles of deiodination, conjugation to ubiquitin, and enzyme reactivation by deubiquitination, allowing tight control of thyroid hormone action...
  25. ncbi request reprint Atypical structure and phylogenomic evolution of the new eutherian oocyte- and embryo-expressed KHDC1/DPPA5/ECAT1/OOEP gene family
    Alice Pierre
    Physiologie de la Reproduction et des Comportements, UMR 6175 INRA CNRS Université F Rabelais de Tours Haras Nationaux, 37380 Nouzilly, France
    Genomics 90:583-94. 2007
    ....
  26. doi request reprint Human mismatch repair protein MSH6 contains a PWWP domain that targets double stranded DNA
    Cedric Laguri
    CEA Laboratoire de Biologie Structurale et Radiobiologie, iBiTec Saclay, 91191 Gif sur Yvette, France
    Biochemistry 47:6199-207. 2008
    ..However, it only moderately affects domain stability, and it does not perturb DNA binding in vitro...
  27. ncbi request reprint In silico identification and structural features of six new genes similar to MATER specifically expressed in the oocyte
    Sébastien Dadé
    Physiologie de la Reproduction et des Comportements, UMR 6175 INRA CNRS Université François Rabelais de Tours Haras Nationaux, 37380 Nouzilly, France
    Biochem Biophys Res Commun 324:547-53. 2004
    ..These experiments confirmed their oocyte restricted expression. Five of these genes are localized on mouse chromosome 7, as is NALP5/MATER; among them, three are localized in a 300 kb cluster...
  28. pmc D53 is a novel endosomal SNARE-binding protein that enhances interaction of syntaxin 1 with the synaptobrevin 2 complex in vitro
    Veronique Proux-Gillardeaux
    Régulations Cellulaires et Oncogénèse, UMR 146 du CNRS, Institut Curie, Centre Universitaire, 91405 Orsay Cedex, France
    Biochem J 370:213-21. 2003
    ..Furthermore, D53 forms Sb2/Stx1/D53 complexes in vitro in a manner similar to SNAP-25. We propose that D53 could be involved in the assembly or disassembly of endosomal SNARE complexes by regulating Sb2/Stx interaction...
  29. pmc An Rpb4/Rpb7-like complex in yeast RNA polymerase III contains the orthologue of mammalian CGRP-RCP
    Magali Siaut
    Service de Biochimie et de Génétique Moléculaire, CEA Saclay, F 91191 Gif sur Yvette Cedex, France
    Mol Cell Biol 23:195-205. 2003
    ..These RNA polymerase subunits appear to have evolved to meet the distinct requirements of the multiple forms of RNA polymerases...
  30. ncbi request reprint Non-intertwined binary patterns of hydrophobic/nonhydrophobic amino acids are considerably better markers of regular secondary structures than nonconstrained patterns
    Jérôme Hennetin
    Systèmes moléculaires and Biologie structurale, LMCP, CNRS UMR 7590, Universités Paris 6 and Paris 7, case 115, 4 place Jussieu, 75252 Paris Cedex 05, France
    Proteins 51:236-44. 2003
    ....
  31. ncbi request reprint Identification and characterization of Moca-cyp. A Drosophila melanogaster nuclear cyclophilin
    Laurent Cavarec
    Laboratoire de génétique oncologique, UMR1599, Institut Gustave Roussy PR1, 39 rue Camille Desmoulins, Villejuif 94805 cedex, France
    J Biol Chem 277:41171-82. 2002
    ..The moca domain is located within the C-terminal tail and is the exclusive hallmark of a group of large cyclophilins found in multicellular organisms of the animal kingdom...
  32. ncbi request reprint A novel DNA repair enzyme containing RNA recognition, G-patch and specific splicing factor 45-like motifs in the protozoan parasite Toxoplasma gondii
    Najoua Dendouga
    Equipe de Parasitologie Moléculaire, Laboratoire de Chimie Biologique, CNRS UMR 8576, Universite des Sciences et Technologies de Lille, France
    Eur J Biochem 269:3393-401. 2002
    ..The presence of these motifs suggests that T. gondii TgDRE might also be involved in other biological functions such as RNA metabolism in addition to DNA-repair...
  33. ncbi request reprint The iodothyronine selenodeiodinases are thioredoxin-fold family proteins containing a glycoside hydrolase clan GH-A-like structure
    Isabelle Callebaut
    Poôle Bio, Laboratoive de Minéralogie Cristallographie de Paris, CNRS UMR7590, Universities Paris 6 and Paris 7, Paris 75252 Cedex 05, France
    J Biol Chem 278:36887-96. 2003
    ..This model can explain a number of results from previous mutagenesis analyses and permits new verifiable insights into the structural and functional properties of these enzymes...
  34. ncbi request reprint The multifunctional protein PEA-15 is involved in the control of apoptosis and cell cycle in astrocytes
    François Renault
    INSERM U114, College de France, 11 place Marcelin Berthelot, 75231 Paris Cedex 05, France
    Biochem Pharmacol 66:1581-8. 2003
    ..The three-dimensional structure of PEA-15 has been modelized and recently determined using NMR spectroscopy, and may help to understand the various functions played by the protein through its molecular interactions...
  35. ncbi request reprint Viral fusion peptides and identification of membrane-interacting segments
    Victoria Dominguez Del Angel
    Systèmes moléculaires and Biologie structurale, LMCP, CNRS UMR 7590, Universités Paris 6 et Paris 7, case 115, 4 place Jussieu, Paris Cedex 05 FR 75252, France
    Biochem Biophys Res Commun 293:1153-60. 2002
    ....
  36. ncbi request reprint Molecular basis of the spectral expression of CIAS1 mutations associated with phagocytic cell-mediated autoinflammatory disorders CINCA/NOMID, MWS, and FCU
    Benedicte Neven
    INSERM U429, Hopital Necker Enfants Malades, Paris, France
    Blood 103:2809-15. 2004
    ....
  37. pmc The A14-A43 heterodimer subunit in yeast RNA pol I and their relationship to Rpb4-Rpb7 pol II subunits
    Gerald Peyroche
    Laboratoire de Transcription des Gènes, Commissariat à l Energie Atomique Saclay, 91191 Gif sur Yvette Cedex, France
    Proc Natl Acad Sci U S A 99:14670-5. 2002
    ..This hypothesis, combined with our structural data, suggests a new localization of Rpb7-Rpb4 subunits in the three-dimensional structure of yeast pol II...
  38. ncbi request reprint Identification of a new expanding family of genes characterized by atypical LRR domains. Localization of a cluster preferentially expressed in oocyte
    Sébastien Dadé
    Physiologie de la Reproduction et des Comportements, UMR 6073 INRA CNRS Université François Rabelais de Tours, 37380, Nouzilly, France
    FEBS Lett 555:533-8. 2003
    ..We thus re-named this latter gene 'oogenesin-1', and the three genes identified here were named oogenesin-2, -3 and -4...
  39. pmc The metallo-beta-lactamase/beta-CASP domain of Artemis constitutes the catalytic core for V(D)J recombination
    Catherine Poinsignon
    Développement Normal et Pathologique de Système Immunitaire, INSERM U429, Hopital Necker Enfants Malades, 75015 Paris, France
    J Exp Med 199:315-21. 2004
    ....
  40. ncbi request reprint 1H, 13C and 15N resonance assignments of the region 1463-1617 of the mouse p53 binding protein 1 (53BP1)
    Gaëlle Charier
    J Biomol NMR 28:303-4. 2004
  41. ncbi request reprint Striking conformational change suspected within the phosphoribulokinase dimer induced by interaction with GAPDH
    Fabrice Mouche
    Laboratoire de Minéralogie Cristallographie Paris, CNRS, UMR 7590, Universités Paris 6 et Paris 7, case 115, 4 place Jussieu, 75252 Paris Cedex 05, France
    J Biol Chem 277:6743-9. 2002
    ....
  42. ncbi request reprint Integrin receptor specificity for human red cell ICAM-4 ligand. Critical residues for alphaIIbeta3 binding
    Patricia Hermand
    INSERM U76, Institut National de la Transfusion Sanguine, Paris, France
    Eur J Biochem 271:3729-40. 2004
    ....
  43. ncbi request reprint The Tudor tandem of 53BP1: a new structural motif involved in DNA and RG-rich peptide binding
    Gaëlle Charier
    Departement d Ingenierie et d Etudes des Proteines, 91191 Gif sur Yvette, France
    Structure 12:1551-62. 2004
    ....
  44. doi request reprint P3 peptide, a truncated form of A beta devoid of synaptotoxic effect, does not assemble into soluble oligomers
    Fabienne Dulin
    CI NAPS, UMR 6232 UCBN CNRS, Centre Cyceron, Bd Henri Becquerel, 14074 Caen Cedex, France
    FEBS Lett 582:1865-70. 2008
    ..These properties may explain why p3 would be devoid of any impact on synaptic function and moreover, strengthen the hypothesis that A beta oligomers are the principal synaptotoxic forms of A beta peptides in Alzheimer disease...
  45. ncbi request reprint The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases
    Vanessa Nancy
    Inserm U 528, Institut Curie Section de Recherche, 75005 Paris, France
    J Biol Chem 277:15076-84. 2002
    ....
  46. ncbi request reprint Characterization of a Type III secretion substrate specificity switch (T3S4) domain in YscP from Yersinia enterocolitica
    Céline Agrain
    Biozentrum der Universitat Basel, Basel, Switzerland
    Mol Microbiol 56:54-67. 2005
    ....
  47. pmc Bovine leukemia virus SU protein interacts with zinc, and mutations within two interacting regions differently affect viral fusion and infectivity in vivo
    Jean Stéphane Gatot
    Unité de Biologie Cellulaire et Moléculaire, Faculté universitaire des Sciences agronomiques, Gembloux, Belgium
    J Virol 76:7956-67. 2002
    ....
  48. pmc GPR50 is the mammalian ortholog of Mel1c: evidence of rapid evolution in mammals
    Laurence Dufourny
    Physiologie de la Reproduction et des Comportements, UMR 6175 INRA CNRS Université François Rabelais de Tours Haras Nationaux, 37380 Nouzilly, France
    BMC Evol Biol 8:105. 2008
    ..The aim of this study was to describe the evolutionary relationships between GPR50 and the three other members of the melatonin receptor subfamily...
  49. ncbi request reprint Preparation of leptin antagonists by site-directed mutagenesis of human, ovine, rat, and mouse leptin's site III: implications on blocking undesired leptin action in vivo
    Gili Solomon
    Faculty of Agricultural, Food, and Environmental Quality Sciences, The Hebrew University of Jerusalem, POB 12, Rehovot 76100, Israel
    Ann N Y Acad Sci 1091:531-9. 2006
    ..Some muteins were pegylated using 40 kDa PEG. Although pegylation decreased the in vitro activity, increasing circulation half-life can recompensate this deficit, so pegylated antagonists are expected to be more potent in vivo...
  50. ncbi request reprint Severe and progressive encephalitis as a presenting manifestation of a novel missense perforin mutation and impaired cytolytic activity
    Jerome Feldmann
    Inistitut National de la Santé et de la Recherche Médicale INSERM U429, Hopital Necker Enfants Malades, 149 rue de Sevres, 75743 Paris, Cedex 15, France
    Blood 105:2658-63. 2005
    ..This observation also raises the question of the role of some mutations in the neurologic expression of FHL...
  51. ncbi request reprint Molecular basis of methylmalonyl-CoA mutase apoenzyme defect in 40 European patients affected by mut(o) and mut- forms of methylmalonic acidemia: identification of 29 novel mutations in the MUT gene
    Cecile Acquaviva
    Fédération de Génétique, Assistance Publique Hopitaux de Paris, Hopital Robert Debre, Paris, France
    Hum Mutat 25:167-76. 2005
    ..shermanii enzyme. In this work we update the spectrum of MCM mutations (n=84), and then discuss their prevalence and distribution throughout the coding sequence in relation to the enzyme structure...
  52. ncbi request reprint Up date on IGFBP-4: regulation of IGFBP-4 levels and functions, in vitro and in vivo
    Sabine Mazerbourg
    Station INRA de Physiologie de la Reproduction et des Comportements, CNRS UMR 6073, Universite Francois Rabelais de Tours, 37380 Nouzilly, France
    Growth Horm IGF Res 14:71-84. 2004
    ..In this review, we have provided an update on IGFBP-4 research and we have summarized our current understanding of the regulation of levels and actions of IGFBP-4 and proteolytic fragments both in vitro and in vivo...
  53. pmc NEDD1-dependent recruitment of the gamma-tubulin ring complex to the centrosome is necessary for centriole duplication and spindle assembly
    Laurence Haren
    Institut de Sciences et Technologies du Medicament de Toulouse, Centre National de la Recherche Scientifique Pierre Fabre, 31400 Toulouse, France
    J Cell Biol 172:505-15. 2006
    ..Further, we show that depletion of NEDD1 inhibits centriole duplication, as does depletion of gamma-tubulin. Our data suggest that centriole duplication requires NEDD1-dependent recruitment of gamma-tubulin to the centrosome...
  54. ncbi request reprint Munc13-4 is essential for cytolytic granules fusion and is mutated in a form of familial hemophagocytic lymphohistiocytosis (FHL3)
    Jerome Feldmann
    INSERM U429, Hopital Necker Enfants Malades, 75743 Paris, France
    Cell 115:461-73. 2003
    ..Expressed tagged hMunc13-4 localizes with cytotoxic granules at the immunological synapse. HMunc13-4 is therefore essential for the priming step of cytolytic granules secretion preceding vesicle membrane fusion...
  55. ncbi request reprint ACCA phosphopeptide recognition by the BRCT repeats of BRCA1
    Hind Ray
    Laboratoire de Genetique Moleculaire, Signalisation et Cancer, CNRS UMR 5201, Faculte de Medecine Rockefeller, 8 avenue Rockefeller, 69373 Lyon Cedex 08, France
    J Mol Biol 359:973-82. 2006
    ..We finally demonstrated by immunoprecipitation of ACCA in cells, that the whole BRCA1 protein interacts with ACCA when phosphorylated on Ser1263...
  56. ncbi request reprint A new rubisco-like protein coexists with a photosynthetic rubisco in the planktonic cyanobacteria Microcystis
    Alyssa Carré-Mlouka
    Departement de Microbiologie, Unité des Cyanobactéries CNRS URA 2172 and Plate forme Génomique Pasteur Génopole Ile de France, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    J Biol Chem 281:24462-71. 2006
    ..The discovery of the coexistence of RbcL(I) and RbcL(IV) in cyanobacteria, the ancestors of chloroplasts, enlightens episodes of the chaotic evolutionary history of the Rubiscos, a protein family of major importance for life on Earth...
  57. ncbi request reprint The V(D)J recombination/DNA repair factor artemis belongs to the metallo-beta-lactamase family and constitutes a critical developmental checkpoint of the lymphoid system
    Despina Moshous
    Unité Développement Normal et Pathologique du Système Immunitaire, INSERM U429, Hopital Necker Enfants Malades, Paris, France
    Ann N Y Acad Sci 987:150-7. 2003
    ..Two of these patients developed aggressive B cell lymphomas, a condition that suggests Artemis may be considered a "caretaker" factor, similarly to the other V(D)J recombination/DNA repair actors...
  58. ncbi request reprint Bromodomain testis-specific protein is expressed in mouse oocyte and evolves faster than its ubiquitously expressed paralogs BRD2, -3, and -4
    Amélie Paillisson
    Physiologie de la Reproduction et des Comportements, UMR 6175 INRA CNRS Université François Rabelais de Tours Haras Nationaux, 37380 Nouzilly, France
    Genomics 89:215-23. 2007
    ..This suggests that there is a relationship between the evolution of these four groups of orthology and their tissue specificity of expression...
  59. ncbi request reprint Phylogenetic analysis and identification of pseudogenes reveal a progressive loss of zona pellucida genes during evolution of vertebrates
    Ghylene Goudet
    Physiologie de la Reproduction et des Comportements, INRA CNRS Université de Tours Haras Nationaux, IFR 135, 37380 Nouzilly, France
    Biol Reprod 78:796-806. 2008
    ..Our review provides new directions to investigate the molecular basis of sperm-egg recognition, a mechanism which is not yet elucidated...