I Callebaut

Summary

Country: France

Publications

  1. ncbi request reprint The uteroglobin fold
    I Callebaut
    Systèmes moléculaires et Biologie structurale, Laboratoire de Minéralogie Cristallographie Paris LMCP, CNRS UMR 7590, Universités Paris 6 et Paris 7, case 115, 4 place Jussieu, 75252 Paris, France
    Ann N Y Acad Sci 923:90-112. 2000
  2. pmc Metallo-beta-lactamase fold within nucleic acids processing enzymes: the beta-CASP family
    Isabelle Callebaut
    Systèmes moléculaires et Biologie structurale, LMCP, CNRS UMR 7590, Universités Paris 6 et Paris 7, case 115, 4 place Jussieu, F 75252 Paris Cedex 05, France
    Nucleic Acids Res 30:3592-601. 2002
  3. ncbi request reprint Nucleotide-binding domains of human cystic fibrosis transmembrane conductance regulator: detailed sequence analysis and three-dimensional modeling of the heterodimer
    I Callebaut
    Systèmes moléculaires and Biologie structurale, LMCP, CNRS UMR7590, Universités Paris 6 and Paris 7, case 115, 4 place Jussieu, 75252 Paris Cedex 05, France
    Cell Mol Life Sci 61:230-42. 2004
  4. ncbi request reprint An EVH1/WH1 domain as a key actor in TGFbeta signalling
    Isabelle Callebaut
    Systèmes moléculaires and Biologie structurale, LMCP, CNRS UMR 7590, Universités Paris 6 and Paris 7, case 115, 4 place Jussieu, Paris, France
    FEBS Lett 519:178-80. 2002
  5. ncbi request reprint EMI domains are widespread and reveal the probable orthologs of the Caenorhabditis elegans CED-1 protein
    Isabelle Callebaut
    Systèmes moléculaires et Biologie structurale, LMCP, CNRS UMR7590, Universités Paris 6 et Paris 7, case 115, 4 place Jussieu, 75252 05 Paris Cedex, France
    Biochem Biophys Res Commun 300:619-23. 2003
  6. ncbi request reprint The V(D)J recombination activating protein RAG2 consists of a six-bladed propeller and a PHD fingerlike domain, as revealed by sequence analysis
    I Callebaut
    Systèmes moléculaires et Biologie structurale, LMCP, CNRS UMR C7590, Paris, France
    Cell Mol Life Sci 54:880-91. 1998
  7. ncbi request reprint Deciphering protein sequence information through hydrophobic cluster analysis (HCA): current status and perspectives
    I Callebaut
    Systèmes moléculaires et Biologie structurale, LMCP, CNRS URA 09, UP6 UP7, Paris, France
    Cell Mol Life Sci 53:621-45. 1997
  8. ncbi request reprint Hydrophobic cluster analysis and modeling of the human Rh protein three-dimensional structures
    I Callebaut
    Département de Biologie Structurale, IMPMC, CNRS UMR7590, Universités Paris VI et Paris VII, case 115, 4, place Jussieu, 75252 Paris Cedex 05, France
    Transfus Clin Biol 13:70-84. 2006
  9. ncbi request reprint Structural features of prions explored by sequence analysis. II. A PrP(Sc) model
    J P Mornon
    Systèmes moléculaires and Biologie structurale, LMCP, CNRS UMR 7590, Universités Paris 6 et Paris 7, case 115, 4 place Jussieu, 75252 Paris Cedex 05, France
    Cell Mol Life Sci 59:2144-54. 2002
  10. ncbi request reprint Molecular organization of a zinc binding n-terminal modulatory domain in a NMDA receptor subunit
    P Paoletti
    Laboratoire de Neurobiologie, CNRS UMR 8544, Ecole Normale Superieure, 46 rue d Ulm, 75005, Paris, France
    Neuron 28:911-25. 2000

Collaborators

Detail Information

Publications85

  1. ncbi request reprint The uteroglobin fold
    I Callebaut
    Systèmes moléculaires et Biologie structurale, Laboratoire de Minéralogie Cristallographie Paris LMCP, CNRS UMR 7590, Universités Paris 6 et Paris 7, case 115, 4 place Jussieu, 75252 Paris, France
    Ann N Y Acad Sci 923:90-112. 2000
    ....
  2. pmc Metallo-beta-lactamase fold within nucleic acids processing enzymes: the beta-CASP family
    Isabelle Callebaut
    Systèmes moléculaires et Biologie structurale, LMCP, CNRS UMR 7590, Universités Paris 6 et Paris 7, case 115, 4 place Jussieu, F 75252 Paris Cedex 05, France
    Nucleic Acids Res 30:3592-601. 2002
    ....
  3. ncbi request reprint Nucleotide-binding domains of human cystic fibrosis transmembrane conductance regulator: detailed sequence analysis and three-dimensional modeling of the heterodimer
    I Callebaut
    Systèmes moléculaires and Biologie structurale, LMCP, CNRS UMR7590, Universités Paris 6 and Paris 7, case 115, 4 place Jussieu, 75252 Paris Cedex 05, France
    Cell Mol Life Sci 61:230-42. 2004
    ..Moreover, additional CFTR-specific features can be identified at the subunit interface, which may play critical roles in active site interdependence and are uncommon in other NBD dimers...
  4. ncbi request reprint An EVH1/WH1 domain as a key actor in TGFbeta signalling
    Isabelle Callebaut
    Systèmes moléculaires and Biologie structurale, LMCP, CNRS UMR 7590, Universités Paris 6 and Paris 7, case 115, 4 place Jussieu, Paris, France
    FEBS Lett 519:178-80. 2002
    ..This finding highlights the pivotal role that the EVH1/WH1 family of domains play in multiple eukaryotic signal transduction pathways...
  5. ncbi request reprint EMI domains are widespread and reveal the probable orthologs of the Caenorhabditis elegans CED-1 protein
    Isabelle Callebaut
    Systèmes moléculaires et Biologie structurale, LMCP, CNRS UMR7590, Universités Paris 6 et Paris 7, case 115, 4 place Jussieu, 75252 05 Paris Cedex, France
    Biochem Biophys Res Commun 300:619-23. 2003
    ..Sequence profiles specific of the EMI family of domains led to identify the probable orthologs of the C. elegans CED-1 protein in mammals and insects, which were yet uncovered...
  6. ncbi request reprint The V(D)J recombination activating protein RAG2 consists of a six-bladed propeller and a PHD fingerlike domain, as revealed by sequence analysis
    I Callebaut
    Systèmes moléculaires et Biologie structurale, LMCP, CNRS UMR C7590, Paris, France
    Cell Mol Life Sci 54:880-91. 1998
    ..Moreover, the presence of a plant homeodomain finger-like motif in the last quarter of the RAG2 sequence suggests a potential interaction of this domain with chromatin components...
  7. ncbi request reprint Deciphering protein sequence information through hydrophobic cluster analysis (HCA): current status and perspectives
    I Callebaut
    Systèmes moléculaires et Biologie structurale, LMCP, CNRS URA 09, UP6 UP7, Paris, France
    Cell Mol Life Sci 53:621-45. 1997
    ..Since the last review of HCA published in 1990 [1], significant improvements have been made and several new facets have been addressed. Here we wish to update and summarize this information...
  8. ncbi request reprint Hydrophobic cluster analysis and modeling of the human Rh protein three-dimensional structures
    I Callebaut
    Département de Biologie Structurale, IMPMC, CNRS UMR7590, Universités Paris VI et Paris VII, case 115, 4, place Jussieu, 75252 Paris Cedex 05, France
    Transfus Clin Biol 13:70-84. 2006
    ..These results provide a basis to further understand the structure/function relationships of Rh proteins, and the alterations occurring in variant phenotypes...
  9. ncbi request reprint Structural features of prions explored by sequence analysis. II. A PrP(Sc) model
    J P Mornon
    Systèmes moléculaires and Biologie structurale, LMCP, CNRS UMR 7590, Universités Paris 6 et Paris 7, case 115, 4 place Jussieu, 75252 Paris Cedex 05, France
    Cell Mol Life Sci 59:2144-54. 2002
    ..Some comments are also devoted to a comparison of the yeast Ure2p prion and animal prions...
  10. ncbi request reprint Molecular organization of a zinc binding n-terminal modulatory domain in a NMDA receptor subunit
    P Paoletti
    Laboratoire de Neurobiologie, CNRS UMR 8544, Ecole Normale Superieure, 46 rue d Ulm, 75005, Paris, France
    Neuron 28:911-25. 2000
    ..Thus, the extracellular region of NR2A consists of a tandem of Venus flytrap domains, one binding the agonist and the other a modulatory ligand. Such a functional organization may apply to other eukaryotic iGluRs...
  11. ncbi request reprint Hydrophobic cluster analysis reveals a third chromodomain in the Tetrahymena Pdd1p protein of the chromo superfamily
    I Callebaut
    Systèmes moléculaires et Biologie structurale, LMCP, CNRS URA09, Universite Paris 6, France
    Biochem Biophys Res Commun 235:103-7. 1997
    ..The results also demonstrate the power of HCA in identifying relationships which are not detected by conventional methods of sequence analysis...
  12. ncbi request reprint Nucleotide binding domains of human CFTR: a structural classification of critical residues and disease-causing mutations
    R Eudes
    Département de Biologie Structurale, IMPMC, CNRS UMR7590, Universités Paris 6 et Paris 7, case 115, 4 place Jussieu, 75252, Paris Cedex 05, France
    Cell Mol Life Sci 62:2112-23. 2005
    ..In particular, a cluster of aromatic amino acids, which includes F508 and straddles the two NBDs, might be directly involved in the interaction of the NBD1/NBD2 heterodimer with the channel-forming membrane-spanning domains...
  13. ncbi request reprint Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency
    D Moshous
    Développement Normal et Pathologique, du Système Immunitaire, INSERM U429, Hopital Necker Enfants Malades, 149 rue de Sevres, 75015, Paris, France
    Cell 105:177-86. 2001
    ..Protein sequence analysis strongly suggests that Artemis belongs to the metallo-beta-lactamase superfamily...
  14. doi request reprint Calcineurin B-like domains in the large regulatory alpha/beta subunits of phosphorylase kinase
    Cathelène Carrière
    Département de Biologie Structurale, Institut de Minéralogie et de Physique des Milieux Condensés, UMR 7590, CNRS, Universités Paris 6 et Paris 7, Paris, France
    Proteins 71:1597-606. 2008
    ..This finding, together the identification of significant similarities of domain D with the preceding domain C, may help to understand the molecular mechanism by which PhK alpha and/or beta domain D might regulate PhK activity...
  15. ncbi request reprint uDENN, DENN, and dDENN: indissociable domains in Rab and MAP kinases signaling pathways
    E Levivier
    Systèmes moléculaires and Biologie structurale, LMCP, CNRS UMR 7590, Universités Paris 6 et Paris 7, case 115, 4 place Jussieu, Paris Cedex 05, 75252, France
    Biochem Biophys Res Commun 287:688-95. 2001
    ..These however share conserved amino acids which could play a key role in the DENN functions...
  16. pmc Delineation of the Xrcc4-interacting region in the globular head domain of cernunnos/XLF
    Laurent Malivert
    INSERM, Hôpital Necker Enfants Malades U768, Unité de Développement Normal et Pathologique du Système Immunitaire, Paris, France
    J Biol Chem 285:26475-83. 2010
    ..Docking the crystal structures of the two factors further validated this probable interaction surface of Cernunnos with X4...
  17. ncbi request reprint Structural features of prions explored by sequence analysis I. Sequence data
    J P Mornon
    Systèmes moléculaires and Biologie structurale, LMCP, CNRS UMR 7590, Universités Paris 6 et Paris 7, France
    Cell Mol Life Sci 59:1366-76. 2002
    ....
  18. ncbi request reprint Characterization of the laminin binding domains of the Lutheran blood group glycoprotein
    W El Nemer
    INSERM U76, Institut National de la Transfusion Sanguine, Paris 75015, France and CNRS UMR7590, Universités Paris 6 et Paris 7, Paris 75005, France
    J Biol Chem 276:23757-62. 2001
    ..Neither the RGD nor the N-glycosylation motifs present in IgSF domain 3 were involved in laminin binding...
  19. ncbi request reprint The iodothyronine selenodeiodinases are thioredoxin-fold family proteins containing a glycoside hydrolase clan GH-A-like structure
    Isabelle Callebaut
    Poôle Bio, Laboratoive de Minéralogie Cristallographie de Paris, CNRS UMR7590, Universities Paris 6 and Paris 7, Paris 75252 Cedex 05, France
    J Biol Chem 278:36887-96. 2003
    ..This model can explain a number of results from previous mutagenesis analyses and permits new verifiable insights into the structural and functional properties of these enzymes...
  20. pmc HYR, an extracellular module involved in cellular adhesion and related to the immunoglobulin-like fold
    I Callebaut
    Systèmes moléculaires and Biologie structurale, LMCP, CNRS UMR 7590, Universite Paris 6, France
    Protein Sci 9:1382-90. 2000
    ....
  21. ncbi request reprint From BRCA1 to RAP1: a widespread BRCT module closely associated with DNA repair
    I Callebaut
    Systèmes moléculaires and Biologie structurale, Laboratoire de Minéralogie Cristallographie, CNRS URA09, Universite Paris 6, France
    FEBS Lett 400:25-30. 1997
    ..90-100 amino acids...
  22. doi request reprint A concanavalin A-like lectin domain in the CHS1/LYST protein, shared by members of the BEACH family
    Agathe Burgess
    INSERM, U768, Paris, F 75015, France
    Bioinformatics 25:1219-22. 2009
    ....
  23. pmc Janus kinases and focal adhesion kinases play in the 4.1 band: a superfamily of band 4.1 domains important for cell structure and signal transduction
    J A Girault
    INSERM U114, College de France, Paris, France
    Mol Med 4:751-69. 1998
    ..1/JEF domain are at the crossroads between cytoskeletal organization and signal transduction in multicellular organisms. Their importance is underlined by the variety of diseases that can result from their mutations...
  24. ncbi request reprint Non-intertwined binary patterns of hydrophobic/nonhydrophobic amino acids are considerably better markers of regular secondary structures than nonconstrained patterns
    Jérôme Hennetin
    Systèmes moléculaires and Biologie structurale, LMCP, CNRS UMR 7590, Universités Paris 6 and Paris 7, case 115, 4 place Jussieu, 75252 Paris Cedex 05, France
    Proteins 51:236-44. 2003
    ....
  25. pmc Prediction of the general transcription factors associated with RNA polymerase II in Plasmodium falciparum: conserved features and differences relative to other eukaryotes
    Isabelle Callebaut
    Centre National de la Recherche Scientifique CNRS UMR7590, Universités Paris 6 et Paris 7, Département de Biologie Structurale, IMPMC, 75252 Paris Cedex 05, France
    BMC Genomics 6:100. 2005
    ..In this study, we have used a combination of sensitive sequence analysis methods to predict the existence of several parasite encoded general transcription factors associated with RNA polymerase II...
  26. ncbi request reprint Integrin receptor specificity for human red cell ICAM-4 ligand. Critical residues for alphaIIbeta3 binding
    Patricia Hermand
    INSERM U76, Institut National de la Transfusion Sanguine, Paris, France
    Eur J Biochem 271:3729-40. 2004
    ....
  27. ncbi request reprint OCRE: a novel domain made of imperfect, aromatic-rich octamer repeats
    Isabelle Callebaut
    Département de Biologie Structurale, LMCP, CNRS UMR7590, Universités Paris 6 and Paris 7, case 115, 4 place Jussieu, 75252 Paris Cedex 05, France Isabelle
    Bioinformatics 21:699-702. 2005
    ....
  28. ncbi request reprint Cernunnos interacts with the XRCC4 x DNA-ligase IV complex and is homologous to the yeast nonhomologous end-joining factor Nej1
    Isabelle Callebaut
    Département de Biologie Structurale, Institut de Minéralogie et de Physique des Milieux Condensés, CNRS UMR7590, Universités Paris 6 et Paris 7, Paris, F 75005 France
    J Biol Chem 281:13857-60. 2006
    ..Altogether these results shed new lights on the last step, the DNA religation, of the NHEJ pathway...
  29. ncbi request reprint Isolated ZP-N domains constitute the N-terminal extensions of Zona Pellucida proteins
    Isabelle Callebaut
    Département de Biologie Structurale, IMPMC UMR 7590, Universités Pierre et Marie Curie Paris6, Paris, France
    Bioinformatics 23:1871-4. 2007
    ....
  30. doi request reprint LOTUS, a new domain associated with small RNA pathways in the germline
    Isabelle Callebaut
    IMPMC UMR7590, Universite Pierre et Marie Curie Paris 6, Paris, France
    Bioinformatics 26:1140-4. 2010
    ..This suggests a germline-specific role in the mRNA localization and/or translation or a specific function toward piRNAs...
  31. pmc A generalized analysis of hydrophobic and loop clusters within globular protein sequences
    Richard Eudes
    Structural Biology Department, IMPMC, CNRS UMR7590, Universités Paris 6 and Paris 7, case 115, 4 place Jussieu, 75252 Paris Cedex 05, France
    BMC Struct Biol 7:2. 2007
    ..These species are characterized only by their hydrophobic/non-hydrophobic dichotomy. This analysis has been extended to loop-forming clusters, using an appropriate loop alphabet...
  32. doi request reprint Molecular models of the open and closed states of the whole human CFTR protein
    Jean Paul Mornon
    IMPMC, UMR7590, CNRS, Universités Pierre et Marie Curie Paris 6 et Denis Diderot Paris 7, 140 rue de Lourmel, Paris, France
    Cell Mol Life Sci 66:3469-86. 2009
    ....
  33. ncbi request reprint Kx, a quantitatively minor protein from human erythrocytes, is palmitoylated in vivo
    F Carbonnet
    Institut National de la Transfusion Sanguine, 6 rue Alexandre Cabanel, Paris, 75015, France
    Biochem Biophys Res Commun 250:569-74. 1998
    ..Palmitoylation of one or several of these cysteines might contribute to anchor the cytoplasmic portion of the Kx protein to the inner surface of red cell membrane...
  34. ncbi request reprint RUN domains: a new family of domains involved in Ras-like GTPase signaling
    I Callebaut
    Systèmes moléculaires et Biologie structurale, CNRS UMR 7590, Universités Paris 6 and Paris 7, case 115, 4 place Jussieu, 75252 Paris 05, Cedex, France
    Trends Biochem Sci 26:79-83. 2001
    ..RUN domains are present in several proteins that are linked particularly to the functions of GTPases in the Rap and Rab families. They could hence play an important role in multiple Ras-like GTPase signaling pathways...
  35. ncbi request reprint The BAH (bromo-adjacent homology) domain: a link between DNA methylation, replication and transcriptional regulation
    I Callebaut
    Systèmes moléculaires and Biologie structurale, LMCP, CNRS UMR 7590, Universite Paris 6, France
    FEBS Lett 446:189-93. 1999
    ..The BAH module might therefore play an important role by linking DNA methylation, replication and transcriptional regulation...
  36. ncbi request reprint Viral fusion peptides and identification of membrane-interacting segments
    Victoria Dominguez Del Angel
    Systèmes moléculaires and Biologie structurale, LMCP, CNRS UMR 7590, Universités Paris 6 et Paris 7, case 115, 4 place Jussieu, Paris Cedex 05 FR 75252, France
    Biochem Biophys Res Commun 293:1153-60. 2002
    ....
  37. pmc An immunophilin that binds M(r) 90,000 heat shock protein: main structural features of a mammalian p59 protein
    I Callebaut
    Département des Macromolécules Biologiques, Centre National de la Recherche Scientifique URA09, Paris, France
    Proc Natl Acad Sci U S A 89:6270-4. 1992
    ..Hsp binding immunophilin may be involved in a number of immunological, endocrinological, and chaperone-mediated pathways...
  38. pmc The LW blood group glycoprotein is homologous to intercellular adhesion molecules
    P Bailly
    Institut National de la Santé et de la Recherche Médicale Unité U76, Institut National de Transfusion Sanguine, Paris, France
    Proc Natl Acad Sci U S A 91:5306-10. 1994
    ..The extracellular domain of LW consists, like that of ICAM-2, of two immunoglobulin-like domains, and the critical residues involved in the binding of LFA-1 to ICAMs were partially conserved in LW...
  39. ncbi request reprint Molecular basis of the spectral expression of CIAS1 mutations associated with phagocytic cell-mediated autoinflammatory disorders CINCA/NOMID, MWS, and FCU
    Benedicte Neven
    INSERM U429, Hopital Necker Enfants Malades, Paris, France
    Blood 103:2809-15. 2004
    ....
  40. ncbi request reprint Striking conformational change suspected within the phosphoribulokinase dimer induced by interaction with GAPDH
    Fabrice Mouche
    Laboratoire de Minéralogie Cristallographie Paris, CNRS, UMR 7590, Universités Paris 6 et Paris 7, case 115, 4 place Jussieu, 75252 Paris Cedex 05, France
    J Biol Chem 277:6743-9. 2002
    ....
  41. doi request reprint Functional analysis of human RhCG: comparison with E. coli ammonium transporter reveals similarities in the pore and differences in the vestibule
    Nedjma Zidi-Yahiaoui
    Institut National de la Sante et de la Recherche Medicale, UMR S665, Paris, France
    Am J Physiol Cell Physiol 297:C537-47. 2009
    ..The impact of the mutations suggests that, although having a common function and a similar channel structure, bacterial AmtB and human Rh vary in several aspects of the NH(3) transport mechanisms...
  42. doi request reprint 3D mapping of glycogenosis-causing mutations in the large regulatory alpha subunit of phosphorylase kinase
    Cathelène Carrière
    Universite Pierre et Marie Curie Paris 6, IMPMC UMR7590, Paris, F 75005, France
    Biochim Biophys Acta 1782:664-70. 2008
    ..Altogether, these results show that PHKA2 missense mutations or small in-frame deletions/insertions may have a direct impact on the PhK alpha functions and provide a framework for further experimental investigation...
  43. ncbi request reprint Characterization and study of a kappa-casein-like chymosin-sensitive linkage
    Isabelle Callebaut
    Département de Biologie Structurale, IMPMC, CNRS UMR7590, Universités Paris 6 et Paris 7, case 115, 4 place Jussieu, 75252 Paris Cedex 05, France
    Biochim Biophys Acta 1749:75-80. 2005
    ..The effect of the enzyme activity of chymosin was thus tested on glutamine synthetase. Chymosin cut the latter at the Phe-Met linkage, suggesting that this system may locally resemble the kappa-casein/chymosin complex...
  44. ncbi request reprint The V(D)J recombination/DNA repair factor artemis belongs to the metallo-beta-lactamase family and constitutes a critical developmental checkpoint of the lymphoid system
    Despina Moshous
    Unité Développement Normal et Pathologique du Système Immunitaire, INSERM U429, Hopital Necker Enfants Malades, Paris, France
    Ann N Y Acad Sci 987:150-7. 2003
    ..Two of these patients developed aggressive B cell lymphomas, a condition that suggests Artemis may be considered a "caretaker" factor, similarly to the other V(D)J recombination/DNA repair actors...
  45. ncbi request reprint Molecular basis of methylmalonyl-CoA mutase apoenzyme defect in 40 European patients affected by mut(o) and mut- forms of methylmalonic acidemia: identification of 29 novel mutations in the MUT gene
    Cecile Acquaviva
    Fédération de Génétique, Assistance Publique Hopitaux de Paris, Hopital Robert Debre, Paris, France
    Hum Mutat 25:167-76. 2005
    ..shermanii enzyme. In this work we update the spectrum of MCM mutations (n=84), and then discuss their prevalence and distribution throughout the coding sequence in relation to the enzyme structure...
  46. ncbi request reprint The glycine residues G551 and G1349 within the ATP-binding cassette signature motifs play critical roles in the activation and inhibition of cystic fibrosis transmembrane conductance regulator channels by phloxine B
    Patricia Melin
    Institut de Physiologie et Biologie Cellulaires, CNRS UMR6187, Universite de Poitiers, 40 Avenue du Recteur Pineau, 86022, Poitiers, France
    J Membr Biol 208:203-12. 2005
    ..These data show that G551 and G1349 control the inhibition and activation of CFTR by these agents, suggesting functional nonequivalence of the signature motifs of NBD in the ABC transporter CFTR...
  47. pmc The discovery of SycO highlights a new function for type III secretion effector chaperones
    Michel Letzelter
    Biozentrum der Universitat Basel, Basel, Switzerland
    EMBO J 25:3223-33. 2006
    ..We propose that covering an MLD might be an essential function of T3S effector chaperones...
  48. pmc The thyroid hormone-inactivating deiodinase functions as a homodimer
    G D Vivek Sagar
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Endocrinol 22:1382-93. 2008
    ..In conclusion, the inactivating deiodinase D3 exists as homo- or heterodimer in living intact cells, a feature that is critical for their catalytic activities...
  49. ncbi request reprint Sequence-based modeling of Abeta42 soluble oligomers
    Fabienne Dulin
    Département de Biologie Structurale, IMPMC, CNRS UMR7590, Universités Pierre et Marie Curie Paris 6 et Denis Diderot Paris 7, F 75005 France
    Biopolymers 85:422-37. 2007
    ..The consistency of these models is discussed with respect to available experimental and theoretical data...
  50. pmc Ubiquitination-induced conformational change within the deiodinase dimer is a switch regulating enzyme activity
    G D Vivek Sagar
    Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell Biol 27:4774-83. 2007
    ..The continuous association of D2 with this regulatory protein complex supports rapid cycles of deiodination, conjugation to ubiquitin, and enzyme reactivation by deubiquitination, allowing tight control of thyroid hormone action...
  51. pmc The checkpoint Saccharomyces cerevisiae Rad9 protein contains a tandem tudor domain that recognizes DNA
    Nathalie Lancelot
    Institut de Biologie et Technologies de Saclay, CEA Saclay, 91191 Gif sur Yvette, France
    Nucleic Acids Res 35:5898-912. 2007
    ..However, their modes of chromatin recognition are different, suggesting that the corresponding interactions are differently regulated...
  52. ncbi request reprint Atypical structure and phylogenomic evolution of the new eutherian oocyte- and embryo-expressed KHDC1/DPPA5/ECAT1/OOEP gene family
    Alice Pierre
    Physiologie de la Reproduction et des Comportements, UMR 6175 INRA CNRS Université F Rabelais de Tours Haras Nationaux, 37380 Nouzilly, France
    Genomics 90:583-94. 2007
    ....
  53. pmc Multiple pathways inhibit NHEJ at telomeres
    Stéphane Marcand
    Centre National de la Recherche Scientifque UMR 217, Institut de Radiobiologie Cellulaire et Moleculaire, CEA Fontenay, 92265 Fontenay aux Roses Cedex, France
    Genes Dev 22:1153-8. 2008
    ..We discuss a possible mechanism that would explain Rif2 multifunctionality at telomeres and the recent evolutionary origin of Rif2 from an origin recognition complex (ORC) subunit...
  54. doi request reprint Human mismatch repair protein MSH6 contains a PWWP domain that targets double stranded DNA
    Cedric Laguri
    CEA Laboratoire de Biologie Structurale et Radiobiologie, iBiTec Saclay, 91191 Gif sur Yvette, France
    Biochemistry 47:6199-207. 2008
    ..However, it only moderately affects domain stability, and it does not perturb DNA binding in vitro...
  55. ncbi request reprint Structural and functional characterization of the TgDRE multidomain protein, a DNA repair enzyme from Toxoplasma gondii
    Karine Frénal
    Unité de Résonance Magnétique Nucléaire des Biomolécules, CNRS URA 2185, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Biochemistry 45:4867-74. 2006
    ..The presence of both RNA- and protein-binding domains seems to indicate that TgDRE could also be involved in RNA metabolism...
  56. ncbi request reprint ATP hydrolysis is essential for the function of the Uup ATP-binding cassette ATPase in precise excision of transposons
    Dorothee Murat
    Unité des Membranes Bactériennes CNRS URA2172, Département de Microbiologie Fondamentale et Médicale, Site Fernbach, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France
    J Biol Chem 281:6850-9. 2006
    ..Analysis of Walker motif B mutants suggests that ATP hydrolysis at the two ABC domains is strictly coordinated and is essential for the function of Uup in vivo...
  57. ncbi request reprint Identification of a new expanding family of genes characterized by atypical LRR domains. Localization of a cluster preferentially expressed in oocyte
    Sébastien Dadé
    Physiologie de la Reproduction et des Comportements, UMR 6073 INRA CNRS Université François Rabelais de Tours, 37380, Nouzilly, France
    FEBS Lett 555:533-8. 2003
    ..We thus re-named this latter gene 'oogenesin-1', and the three genes identified here were named oogenesin-2, -3 and -4...
  58. ncbi request reprint The multifunctional protein PEA-15 is involved in the control of apoptosis and cell cycle in astrocytes
    François Renault
    INSERM U114, College de France, 11 place Marcelin Berthelot, 75231 Paris Cedex 05, France
    Biochem Pharmacol 66:1581-8. 2003
    ..The three-dimensional structure of PEA-15 has been modelized and recently determined using NMR spectroscopy, and may help to understand the various functions played by the protein through its molecular interactions...
  59. pmc The A14-A43 heterodimer subunit in yeast RNA pol I and their relationship to Rpb4-Rpb7 pol II subunits
    Gerald Peyroche
    Laboratoire de Transcription des Gènes, Commissariat à l Energie Atomique Saclay, 91191 Gif sur Yvette Cedex, France
    Proc Natl Acad Sci U S A 99:14670-5. 2002
    ..This hypothesis, combined with our structural data, suggests a new localization of Rpb7-Rpb4 subunits in the three-dimensional structure of yeast pol II...
  60. pmc The metallo-beta-lactamase/beta-CASP domain of Artemis constitutes the catalytic core for V(D)J recombination
    Catherine Poinsignon
    Développement Normal et Pathologique de Système Immunitaire, INSERM U429, Hopital Necker Enfants Malades, 75015 Paris, France
    J Exp Med 199:315-21. 2004
    ....
  61. ncbi request reprint 1H, 13C and 15N resonance assignments of the region 1463-1617 of the mouse p53 binding protein 1 (53BP1)
    Gaëlle Charier
    J Biomol NMR 28:303-4. 2004
  62. pmc D53 is a novel endosomal SNARE-binding protein that enhances interaction of syntaxin 1 with the synaptobrevin 2 complex in vitro
    Veronique Proux-Gillardeaux
    Régulations Cellulaires et Oncogénèse, UMR 146 du CNRS, Institut Curie, Centre Universitaire, 91405 Orsay Cedex, France
    Biochem J 370:213-21. 2003
    ..Furthermore, D53 forms Sb2/Stx1/D53 complexes in vitro in a manner similar to SNAP-25. We propose that D53 could be involved in the assembly or disassembly of endosomal SNARE complexes by regulating Sb2/Stx interaction...
  63. ncbi request reprint The yeast Sar exchange factor Sec12, and its higher organism orthologs, fold as beta-propellers
    Pierre Chardin
    FEBS Lett 525:171-3. 2002
  64. ncbi request reprint The Tudor tandem of 53BP1: a new structural motif involved in DNA and RG-rich peptide binding
    Gaëlle Charier
    Departement d Ingenierie et d Etudes des Proteines, 91191 Gif sur Yvette, France
    Structure 12:1551-62. 2004
    ....
  65. ncbi request reprint In silico identification and structural features of six new genes similar to MATER specifically expressed in the oocyte
    Sébastien Dadé
    Physiologie de la Reproduction et des Comportements, UMR 6175 INRA CNRS Université François Rabelais de Tours Haras Nationaux, 37380 Nouzilly, France
    Biochem Biophys Res Commun 324:547-53. 2004
    ..These experiments confirmed their oocyte restricted expression. Five of these genes are localized on mouse chromosome 7, as is NALP5/MATER; among them, three are localized in a 300 kb cluster...
  66. ncbi request reprint Identification and characterization of Moca-cyp. A Drosophila melanogaster nuclear cyclophilin
    Laurent Cavarec
    Laboratoire de génétique oncologique, UMR1599, Institut Gustave Roussy PR1, 39 rue Camille Desmoulins, Villejuif 94805 cedex, France
    J Biol Chem 277:41171-82. 2002
    ..The moca domain is located within the C-terminal tail and is the exclusive hallmark of a group of large cyclophilins found in multicellular organisms of the animal kingdom...
  67. pmc The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate
    Monica Dentice
    Thyroid Section, Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Nat Cell Biol 7:698-705. 2005
    ..Thus, ECS(WSB-1) mediates a mechanism by which 'systemic' thyroid hormone can effect local control of the Hedgehog-PTHrP negative feedback loop and thus skeletogenesis...
  68. pmc Identification of the hydrophobic strand in the A-B loop of leptin as major binding site III: implications for large-scale preparation of potent recombinant human and ovine leptin antagonists
    Leonora Niv-Spector
    Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University, Rehovot 76100, Israel
    Biochem J 391:221-30. 2005
    ....
  69. pmc An Rpb4/Rpb7-like complex in yeast RNA polymerase III contains the orthologue of mammalian CGRP-RCP
    Magali Siaut
    Service de Biochimie et de Génétique Moléculaire, CEA Saclay, F 91191 Gif sur Yvette Cedex, France
    Mol Cell Biol 23:195-205. 2003
    ..These RNA polymerase subunits appear to have evolved to meet the distinct requirements of the multiple forms of RNA polymerases...
  70. pmc Identification, characterization and metagenome analysis of oocyte-specific genes organized in clusters in the mouse genome
    Amélie Paillisson
    Physiologie de la Reproduction et des Comportements, UMR 6175 INRA CNRS Université François Rabelais de Tours Haras Nationaux, 37380 Nouzilly, France
    BMC Genomics 6:76. 2005
    ..In an attempt to identify novel oocyte-specific genes in the mouse, we have used an in silico subtraction methodology, and we have focused our attention on genes that are organized in genomic clusters...
  71. ncbi request reprint A novel DNA repair enzyme containing RNA recognition, G-patch and specific splicing factor 45-like motifs in the protozoan parasite Toxoplasma gondii
    Najoua Dendouga
    Equipe de Parasitologie Moléculaire, Laboratoire de Chimie Biologique, CNRS UMR 8576, Universite des Sciences et Technologies de Lille, France
    Eur J Biochem 269:3393-401. 2002
    ..The presence of these motifs suggests that T. gondii TgDRE might also be involved in other biological functions such as RNA metabolism in addition to DNA-repair...
  72. ncbi request reprint The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases
    Vanessa Nancy
    Inserm U 528, Institut Curie Section de Recherche, 75005 Paris, France
    J Biol Chem 277:15076-84. 2002
    ....
  73. pmc Bovine leukemia virus SU protein interacts with zinc, and mutations within two interacting regions differently affect viral fusion and infectivity in vivo
    Jean Stéphane Gatot
    Unité de Biologie Cellulaire et Moléculaire, Faculté universitaire des Sciences agronomiques, Gembloux, Belgium
    J Virol 76:7956-67. 2002
    ....
  74. pmc GPR50 is the mammalian ortholog of Mel1c: evidence of rapid evolution in mammals
    Laurence Dufourny
    Physiologie de la Reproduction et des Comportements, UMR 6175 INRA CNRS Université François Rabelais de Tours Haras Nationaux, 37380 Nouzilly, France
    BMC Evol Biol 8:105. 2008
    ..The aim of this study was to describe the evolutionary relationships between GPR50 and the three other members of the melatonin receptor subfamily...
  75. doi request reprint P3 peptide, a truncated form of A beta devoid of synaptotoxic effect, does not assemble into soluble oligomers
    Fabienne Dulin
    CI NAPS, UMR 6232 UCBN CNRS, Centre Cyceron, Bd Henri Becquerel, 14074 Caen Cedex, France
    FEBS Lett 582:1865-70. 2008
    ..These properties may explain why p3 would be devoid of any impact on synaptic function and moreover, strengthen the hypothesis that A beta oligomers are the principal synaptotoxic forms of A beta peptides in Alzheimer disease...
  76. ncbi request reprint Phylogenetic analysis and identification of pseudogenes reveal a progressive loss of zona pellucida genes during evolution of vertebrates
    Ghylene Goudet
    Physiologie de la Reproduction et des Comportements, INRA CNRS Université de Tours Haras Nationaux, IFR 135, 37380 Nouzilly, France
    Biol Reprod 78:796-806. 2008
    ..Our review provides new directions to investigate the molecular basis of sperm-egg recognition, a mechanism which is not yet elucidated...
  77. ncbi request reprint Characterization of a Type III secretion substrate specificity switch (T3S4) domain in YscP from Yersinia enterocolitica
    Céline Agrain
    Biozentrum der Universitat Basel, Basel, Switzerland
    Mol Microbiol 56:54-67. 2005
    ....
  78. ncbi request reprint ACCA phosphopeptide recognition by the BRCT repeats of BRCA1
    Hind Ray
    Laboratoire de Genetique Moleculaire, Signalisation et Cancer, CNRS UMR 5201, Faculte de Medecine Rockefeller, 8 avenue Rockefeller, 69373 Lyon Cedex 08, France
    J Mol Biol 359:973-82. 2006
    ..We finally demonstrated by immunoprecipitation of ACCA in cells, that the whole BRCA1 protein interacts with ACCA when phosphorylated on Ser1263...
  79. ncbi request reprint A new rubisco-like protein coexists with a photosynthetic rubisco in the planktonic cyanobacteria Microcystis
    Alyssa Carré-Mlouka
    Departement de Microbiologie, Unité des Cyanobactéries CNRS URA 2172 and Plate forme Génomique Pasteur Génopole Ile de France, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    J Biol Chem 281:24462-71. 2006
    ..The discovery of the coexistence of RbcL(I) and RbcL(IV) in cyanobacteria, the ancestors of chloroplasts, enlightens episodes of the chaotic evolutionary history of the Rubiscos, a protein family of major importance for life on Earth...
  80. ncbi request reprint Severe and progressive encephalitis as a presenting manifestation of a novel missense perforin mutation and impaired cytolytic activity
    Jerome Feldmann
    Inistitut National de la Santé et de la Recherche Médicale INSERM U429, Hopital Necker Enfants Malades, 149 rue de Sevres, 75743 Paris, Cedex 15, France
    Blood 105:2658-63. 2005
    ..This observation also raises the question of the role of some mutations in the neurologic expression of FHL...
  81. ncbi request reprint Up date on IGFBP-4: regulation of IGFBP-4 levels and functions, in vitro and in vivo
    Sabine Mazerbourg
    Station INRA de Physiologie de la Reproduction et des Comportements, CNRS UMR 6073, Universite Francois Rabelais de Tours, 37380 Nouzilly, France
    Growth Horm IGF Res 14:71-84. 2004
    ..In this review, we have provided an update on IGFBP-4 research and we have summarized our current understanding of the regulation of levels and actions of IGFBP-4 and proteolytic fragments both in vitro and in vivo...
  82. ncbi request reprint Preparation of leptin antagonists by site-directed mutagenesis of human, ovine, rat, and mouse leptin's site III: implications on blocking undesired leptin action in vivo
    Gili Solomon
    Faculty of Agricultural, Food, and Environmental Quality Sciences, The Hebrew University of Jerusalem, POB 12, Rehovot 76100, Israel
    Ann N Y Acad Sci 1091:531-9. 2006
    ..Some muteins were pegylated using 40 kDa PEG. Although pegylation decreased the in vitro activity, increasing circulation half-life can recompensate this deficit, so pegylated antagonists are expected to be more potent in vivo...
  83. pmc NEDD1-dependent recruitment of the gamma-tubulin ring complex to the centrosome is necessary for centriole duplication and spindle assembly
    Laurence Haren
    Institut de Sciences et Technologies du Medicament de Toulouse, Centre National de la Recherche Scientifique Pierre Fabre, 31400 Toulouse, France
    J Cell Biol 172:505-15. 2006
    ..Further, we show that depletion of NEDD1 inhibits centriole duplication, as does depletion of gamma-tubulin. Our data suggest that centriole duplication requires NEDD1-dependent recruitment of gamma-tubulin to the centrosome...
  84. ncbi request reprint Munc13-4 is essential for cytolytic granules fusion and is mutated in a form of familial hemophagocytic lymphohistiocytosis (FHL3)
    Jerome Feldmann
    INSERM U429, Hopital Necker Enfants Malades, 75743 Paris, France
    Cell 115:461-73. 2003
    ..Expressed tagged hMunc13-4 localizes with cytotoxic granules at the immunological synapse. HMunc13-4 is therefore essential for the priming step of cytolytic granules secretion preceding vesicle membrane fusion...
  85. ncbi request reprint Bromodomain testis-specific protein is expressed in mouse oocyte and evolves faster than its ubiquitously expressed paralogs BRD2, -3, and -4
    Amélie Paillisson
    Physiologie de la Reproduction et des Comportements, UMR 6175 INRA CNRS Université François Rabelais de Tours Haras Nationaux, 37380 Nouzilly, France
    Genomics 89:215-23. 2007
    ..This suggests that there is a relationship between the evolution of these four groups of orthology and their tissue specificity of expression...