P R Burgel

Summary

Country: France

Publications

  1. pmc Roles of epidermal growth factor receptor activation in epithelial cell repair and mucin production in airway epithelium
    P R Burgel
    Service de Pneumologie, Hopital Cochin, Universite Rene Descartes, Hopital Cochin, Paris, France
    Thorax 59:992-6. 2004
  2. doi request reprint Non-classic cystic fibrosis associated with D1152H CFTR mutation
    P R Burgel
    Hopital Cochin, APHP, Universite Paris Descartes, Paris, France
    Clin Genet 77:355-64. 2010
  3. doi request reprint The role of small airways in obstructive airway diseases
    P R Burgel
    Service de Pneumologie, Hopital Cochin, AP HP, 27 rue du Faubourg St Jacques, Paris, France
    Eur Respir Rev 20:23-33. 2011
  4. doi request reprint Update on the roles of distal airways in COPD
    P R Burgel
    Service de Pneumologie, Hopital Cochin, 27 rue du Faubourg St Jacques, Universite Paris Descartes, Paris, France
    Eur Respir Rev 20:7-22. 2011
  5. doi request reprint [Management of acute and severe complications in adults with cystic fibrosis]
    J Chapron
    Service de Pneumologie, centre de ressources et de compétences pour la mucoviscidose de l adulte, Hopital Cochin, AP HP, Universite Paris Descartes, 27, rue du Faubourg Saint Jacques, 75014 Paris, France
    Rev Mal Respir 28:503-16. 2011
  6. doi request reprint [Structural abnormalities and inflammation in COPD: a focus on small airways]
    P R Burgel
    Service de Pneumologie, Hopital Cochin, AP HP, Universite Paris Descartes, Paris, France
    Rev Mal Respir 28:749-60. 2011
  7. doi request reprint Pneumococcal infections: association with asthma and COPD
    J Obert
    Service de Pneumologie, Hopital Cochin, AP HP, Universite Paris Descartes, Sorbonne Paris Cité, 27, rue du Faubourg St Jacques, 75014 Paris, France
    Med Mal Infect 42:188-92. 2012
  8. doi request reprint [Eosinophilic pleural effusion related to taking valproic acid]
    C Bally
    Service de Pneumologie, Hopital Cochin, Paris, France
    Rev Pneumol Clin 67:363-6. 2011
  9. doi request reprint Pseudomonas aeruginosa induces vascular endothelial growth factor synthesis in airway epithelium in vitro and in vivo
    C Martin
    Universite Paris Descartes, Sorbonne Paris Cité, Faculte de Medecine, UPRES EA 2511, Paris, France
    Eur Respir J 38:939-46. 2011
  10. doi request reprint Critical role of cytosolic phospholipase A2{alpha} in bronchial mucus hypersecretion in CFTR-deficient mice
    F Dif
    Unité de Défense Innée et Inflammation, INSERM, Paris, France
    Eur Respir J 36:1120-30. 2010

Collaborators

Detail Information

Publications20

  1. pmc Roles of epidermal growth factor receptor activation in epithelial cell repair and mucin production in airway epithelium
    P R Burgel
    Service de Pneumologie, Hopital Cochin, Universite Rene Descartes, Hopital Cochin, Paris, France
    Thorax 59:992-6. 2004
    ..EGFR pathways have also been implicated in the repair of damaged airway epithelium. The roles of EGFR in airway epithelial cell hypersecretion and epithelial damage and repair are reviewed and future potential treatments are suggested...
  2. doi request reprint Non-classic cystic fibrosis associated with D1152H CFTR mutation
    P R Burgel
    Hopital Cochin, APHP, Universite Paris Descartes, Paris, France
    Clin Genet 77:355-64. 2010
    ..Limited knowledge exists on phenotypes associated with the D1152H cystic fibrosis transmembrane conductance regulator (CFTR) mutation...
  3. doi request reprint The role of small airways in obstructive airway diseases
    P R Burgel
    Service de Pneumologie, Hopital Cochin, AP HP, 27 rue du Faubourg St Jacques, Paris, France
    Eur Respir Rev 20:23-33. 2011
    ..The availability of these techniques coupled with our ability to better target inhaled molecules to small airways provide a unique opportunity for a reappraisal of the relevance of small airways in chronic airway diseases...
  4. doi request reprint Update on the roles of distal airways in COPD
    P R Burgel
    Service de Pneumologie, Hopital Cochin, 27 rue du Faubourg St Jacques, Universite Paris Descartes, Paris, France
    Eur Respir Rev 20:7-22. 2011
    ..g. dyspnoea and reduced health-related quality of life) and with the natural history of the disease, as reflected by lung function decline and mortality. These data provide a clear rationale for targeting distal airways in COPD...
  5. doi request reprint [Management of acute and severe complications in adults with cystic fibrosis]
    J Chapron
    Service de Pneumologie, centre de ressources et de compétences pour la mucoviscidose de l adulte, Hopital Cochin, AP HP, Universite Paris Descartes, 27, rue du Faubourg Saint Jacques, 75014 Paris, France
    Rev Mal Respir 28:503-16. 2011
    ..Therapeutic options should always have been discussed between the patient, family members and the CF medical team to allow for informed decision making...
  6. doi request reprint [Structural abnormalities and inflammation in COPD: a focus on small airways]
    P R Burgel
    Service de Pneumologie, Hopital Cochin, AP HP, Universite Paris Descartes, Paris, France
    Rev Mal Respir 28:749-60. 2011
    ..These data suggest a potential role for therapies that can target remodelling and inflammation in the small airways of patients with COPD...
  7. doi request reprint Pneumococcal infections: association with asthma and COPD
    J Obert
    Service de Pneumologie, Hopital Cochin, AP HP, Universite Paris Descartes, Sorbonne Paris Cité, 27, rue du Faubourg St Jacques, 75014 Paris, France
    Med Mal Infect 42:188-92. 2012
    ..The recent availability of pneumococcal conjugate vaccines could be interesting for these patients, but their clinical and cost effectiveness will have to be demonstrated before they can be recommended for these conditions...
  8. doi request reprint [Eosinophilic pleural effusion related to taking valproic acid]
    C Bally
    Service de Pneumologie, Hopital Cochin, Paris, France
    Rev Pneumol Clin 67:363-6. 2011
    ..Valproic acid is a rare cause of eosinophilic pleural effusion. The effusion usually regresses when treatment is discontinued but short-term oral corticotherapy may be necessary in order to heal the patient...
  9. doi request reprint Pseudomonas aeruginosa induces vascular endothelial growth factor synthesis in airway epithelium in vitro and in vivo
    C Martin
    Universite Paris Descartes, Sorbonne Paris Cité, Faculte de Medecine, UPRES EA 2511, Paris, France
    Eur Respir J 38:939-46. 2011
    ..These effects were reduced by EGFR inhibition. Persistent PA infection induced VEGF synthesis in airway epithelium and peribronchial angiogenesis, at least in part via EGFR-dependent mechanisms...
  10. doi request reprint Critical role of cytosolic phospholipase A2{alpha} in bronchial mucus hypersecretion in CFTR-deficient mice
    F Dif
    Unité de Défense Innée et Inflammation, INSERM, Paris, France
    Eur Respir J 36:1120-30. 2010
    ..This led to an enhanced mucus production in airway epithelia independent of CFTR chloride transport function. cPLA2α represents a suitable new target for therapeutic intervention in CF...
  11. doi request reprint [Eosinophilic pleural effusion associated to Churg and Strauss syndrome]
    D Natali
    Service de Pneumologie, Faculté de Médecine Paris Descartes, Universite Paris Descartes, Hopital Cochin, Assistance Publique Hopitaux de Paris, 27, rue du Faubourg Saint Jacques, 75679 Paris Cedex 14, France
    Rev Pneumol Clin 64:229-33. 2008
    ..This case report enables us to discuss the different causes of EPE and to illustrate how it may be a manifestation of Churg and Strauss syndrome...
  12. doi request reprint Update on the roles of distal airways in asthma
    P R Burgel
    Hopital Cochin, AP HP, Universite Paris Descartes, Paris, France
    Eur Respir Rev 18:80-95. 2009
    ..However, available studies have not yet demonstrated that extra-fine inhaled medications offer increased benefit compared with usual aerosols in asthmatic patients...
  13. ncbi request reprint [Treatments targeting distal airways in asthma: update on clinical studies]
    P R Burgel
    Service de Pneumologie, Hopital Cochin, Universite Paris Descartes, Assistance Publique des Hopitaux de Paris, Paris, France
    Rev Mal Respir 26:859-66. 2009
    ..The available studies have not yet demonstrated a long-term benefit in terms of additional clinical efficacy of these ultrafine inhaled medications on symptoms, control and exacerbations of asthma...
  14. doi request reprint Epidermal growth factor receptor-mediated innate immune responses and their roles in airway diseases
    P R Burgel
    Service de Pneumologie and UPRES EA 2511, Universite Paris Descartes, Hopital Cochin, Assistance Publique Hopitaux de Paris, Paris, France
    Eur Respir J 32:1068-81. 2008
    ..In considering each therapeutic intervention, the potential benefits must be considered in relation to potential deleterious effects...
  15. ncbi request reprint [Antibiotics for acute exacerbations of chronic obstructive pulmonary disease (COPD)]
    P R Burgel
    Service de Pneumologie, Hopital Cochin, Faculte de Medecine, APHP, Universite Paris Descartes, 27, rue du Faubourg Saint Jacques, 75679 Paris Cedex 14, France
    Med Mal Infect 36:706-17. 2006
    ..This study had for aim to evaluate the rationale and indications for antibiotic treatment in acute exacerbations of COPD and to identify potential differences among various antibiotics available for the treatment of exacerbations in France...
  16. ncbi request reprint [The history of respiratory tests and the pneumologist]
    P R Burgel
    Hopital Cochin, Paris
    Rev Pneumol Clin 61:5S8-5S9. 2005
  17. doi request reprint Clinical COPD phenotypes: a novel approach using principal component and cluster analyses
    P R Burgel
    Service de Pneumologie, Hopital Cochin, Assistance Publique Hopitaux de Paris, 27 rue du Faubourg St Jacques, 75679 Paris Cedex 14, France
    Eur Respir J 36:531-9. 2010
    ..These analyses underscore the need for novel multidimensional COPD classification for improving patient care and quality of clinical trials...
  18. pmc Muco-ciliary differentiation of nasal epithelial cells is decreased after wound healing in vitro
    D S Lazard
    INSERM U955 and Université Paris 12, Creteil, Hopital Armand Trousseau, Paris, France
    Allergy 64:1136-43. 2009
    ..The aim of this study was to evaluate the differentiation of human nasal epithelial cells (HNEC) after wound healing and the potential effects of TGF-beta1...
  19. ncbi request reprint [The diagnosis of cystic fibrosis in adults: lessons from a family story]
    T Coman
    Service de Pneumologie et Centre de Ressources et de Compétences pour la Mucoviscidose CRCM adulte, GHU Ouest, Hopital Cochin, AP HP, Paris, France
    Rev Mal Respir 26:67-73. 2009
    ..Cystic fibrosis is usually diagnosed during the first years of life. Diagnosis may be achieved in adults with milder forms of the disease at any age...
  20. ncbi request reprint Intranasal steroids decrease eosinophils but not mucin expression in nasal polyps
    P R Burgel
    Cardiovascular Research Institute, Box 0130, University of California San Francisco, San Francisco, CA 94 143 0130, USA
    Eur Respir J 24:594-600. 2004
    ..Intranasal fluticasone was effective in decreasing nasal airflow resistance and intra-epithelial eosinophils but had no effect on mucin or epidermal growth factor receptor expression or on neutrophil recruitment...