Remy Burcelin

Summary

Country: France

Publications

  1. doi request reprint Leptin and resistin: master enemy adipokines unified in brain to control glucose homeostasis
    Remy Burcelin
    Unité Mixte de Recherche 5018 Centre National de la Recherche Scientifique University Paul Sabatier, Laboratoire de Neurobiologie, Plasticite Tissulaire, et Metabolism Energetique, Toulouse, France
    Endocrinology 149:443-4. 2008
  2. doi request reprint Pancreatic alpha-cell dysfunction in diabetes
    R Burcelin
    Institute of Molecular Medicine, team Functional genomic of metabolic diseases, Rangueil Hospital, 1, av Prof Jean Poulhes, 31403 Toulouse Cedex, France
    Diabetes Metab 34:S49-55. 2008
  3. ncbi request reprint The incretins: a link between nutrients and well-being
    Remy Burcelin
    UMR 5018 CNRS UPS and IFR 31, Rangueil Hospital, Toulouse, France
    Br J Nutr 93:S147-56. 2005
  4. pmc Prevention of obesity and insulin resistance by estrogens requires ERα activation function-2 (ERαAF-2), whereas ERαAF-1 is dispensable
    Sandra Handgraaf
    INSERM U1048, Institut des Maladies Métaboliques et Cardiovasculaires, Universite Toulouse III, Toulouse, France
    Diabetes 62:4098-108. 2013
  5. pmc Brain GLP-1 signaling regulates femoral artery blood flow and insulin sensitivity through hypothalamic PKC-δ
    Cendrine Cabou
    INSERM U1048, Institute of Metabolic and Cardiovascular Diseases, Rangueil, Universite Paul Sabatier, Toulouse, France
    Diabetes 60:2245-56. 2011
  6. ncbi request reprint Intracerebroventricular infusion of glucose, insulin, and the adenosine monophosphate-activated kinase activator, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside, controls muscle glycogen synthesis
    Christophe Perrin
    Unité Mixte de Recherche 5018, Centre National de la Recherche Scientifique Paul Sabatier University and Institut Federatif de Recherche 31, Rangueil Hospital, L1 Building, 31403 Toulouse, France
    Endocrinology 145:4025-33. 2004
  7. pmc High-fat diet induces periodontitis in mice through lipopolysaccharides (LPS) receptor signaling: protective action of estrogens
    Vincent Blasco-Baque
    Institut National de la Sante et de la Recherche Medicale INSERM, Toulouse, France
    PLoS ONE 7:e48220. 2012
  8. pmc Role of central nervous system glucagon-like Peptide-1 receptors in enteric glucose sensing
    Claude Knauf
    Institut de Medecine Moleculaire de Rangueil, Institut National de la Santé et de la Recherche Médicale U858, IFR31, Centre Hospitalier Universitaire Rangueil, Toulouse, France
    Diabetes 57:2603-12. 2008
  9. doi request reprint Metagenome and metabolism: the tissue microbiota hypothesis
    Remy Burcelin
    Institut National de Sante et de Recherche Medicale INSERM, U1048, Toulouse, France
    Diabetes Obes Metab 15:61-70. 2013
  10. pmc Lipid-induced peroxidation in the intestine is involved in glucose homeostasis imbalance in mice
    Matteo Serino
    Institut National de la Sante et de la Recherche Medicale, U1048, Toulouse, France
    PLoS ONE 6:e21184. 2011

Collaborators

Detail Information

Publications37

  1. doi request reprint Leptin and resistin: master enemy adipokines unified in brain to control glucose homeostasis
    Remy Burcelin
    Unité Mixte de Recherche 5018 Centre National de la Recherche Scientifique University Paul Sabatier, Laboratoire de Neurobiologie, Plasticite Tissulaire, et Metabolism Energetique, Toulouse, France
    Endocrinology 149:443-4. 2008
  2. doi request reprint Pancreatic alpha-cell dysfunction in diabetes
    R Burcelin
    Institute of Molecular Medicine, team Functional genomic of metabolic diseases, Rangueil Hospital, 1, av Prof Jean Poulhes, 31403 Toulouse Cedex, France
    Diabetes Metab 34:S49-55. 2008
    ..Certainly, strategies aiming to restore glucose-regulated glucagon secretion are important milestones for the treatment of diabetic patient and the prevention of iatrogenic hypoglycaemia...
  3. ncbi request reprint The incretins: a link between nutrients and well-being
    Remy Burcelin
    UMR 5018 CNRS UPS and IFR 31, Rangueil Hospital, Toulouse, France
    Br J Nutr 93:S147-56. 2005
    ..The control of incretin secretion represents a major goal for new therapeutic as well as nutrition strategies for treating and/or reducing the risk of hyperglycaemic syndromes, excessive body weight and thus improvement of well-being...
  4. pmc Prevention of obesity and insulin resistance by estrogens requires ERα activation function-2 (ERαAF-2), whereas ERαAF-1 is dispensable
    Sandra Handgraaf
    INSERM U1048, Institut des Maladies Métaboliques et Cardiovasculaires, Universite Toulouse III, Toulouse, France
    Diabetes 62:4098-108. 2013
    ....
  5. pmc Brain GLP-1 signaling regulates femoral artery blood flow and insulin sensitivity through hypothalamic PKC-δ
    Cendrine Cabou
    INSERM U1048, Institute of Metabolic and Cardiovascular Diseases, Rangueil, Universite Paul Sabatier, Toulouse, France
    Diabetes 60:2245-56. 2011
    ....
  6. ncbi request reprint Intracerebroventricular infusion of glucose, insulin, and the adenosine monophosphate-activated kinase activator, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside, controls muscle glycogen synthesis
    Christophe Perrin
    Unité Mixte de Recherche 5018, Centre National de la Recherche Scientifique Paul Sabatier University and Institut Federatif de Recherche 31, Rangueil Hospital, L1 Building, 31403 Toulouse, France
    Endocrinology 145:4025-33. 2004
    ..Although the above mechanisms are correlated with the regulation of AMP-activated kinase, the direct involvement of the enzyme in the mechanism remains to be demonstrated...
  7. pmc High-fat diet induces periodontitis in mice through lipopolysaccharides (LPS) receptor signaling: protective action of estrogens
    Vincent Blasco-Baque
    Institut National de la Sante et de la Recherche Medicale INSERM, Toulouse, France
    PLoS ONE 7:e48220. 2012
    ..In this study, we evaluated whether diet-induced metabolic disease would favor the development of periodontitis in mice. In addition, the regulatory role of estrogens in this process was assessed...
  8. pmc Role of central nervous system glucagon-like Peptide-1 receptors in enteric glucose sensing
    Claude Knauf
    Institut de Medecine Moleculaire de Rangueil, Institut National de la Santé et de la Recherche Médicale U858, IFR31, Centre Hospitalier Universitaire Rangueil, Toulouse, France
    Diabetes 57:2603-12. 2008
    ..The aim of this study was to determine the cells in the brain targeted by the activation of the enteric glucose-sensing system...
  9. doi request reprint Metagenome and metabolism: the tissue microbiota hypothesis
    Remy Burcelin
    Institut National de Sante et de Recherche Medicale INSERM, U1048, Toulouse, France
    Diabetes Obes Metab 15:61-70. 2013
    ....
  10. pmc Lipid-induced peroxidation in the intestine is involved in glucose homeostasis imbalance in mice
    Matteo Serino
    Institut National de la Sante et de la Recherche Medicale, U1048, Toulouse, France
    PLoS ONE 6:e21184. 2011
    ..The study aimed at comparing the effect of Medialipid (ML) overload on insulin secretion and sensitivity when administered either through the intestine or the carotid artery in mice...
  11. pmc Brain glucagon-like peptide-1 regulates arterial blood flow, heart rate, and insulin sensitivity
    Cendrine Cabou
    Institut National de la Sante et de la Recherche Medicale INSERM, U858, Institute of Molecular Medicine Rangueil, Toulouse, France
    Diabetes 57:2577-87. 2008
    ..GLP-1 is also produced in the brain, where its contribution to central regulation of metabolic and cardiovascular homeostasis remains incompletely understood...
  12. pmc Apelin treatment increases complete Fatty Acid oxidation, mitochondrial oxidative capacity, and biogenesis in muscle of insulin-resistant mice
    Camille Attane
    INSERM U1048, Toulouse, France
    Diabetes 61:310-20. 2012
    ....
  13. pmc Metabolic adaptation to a high-fat diet is associated with a change in the gut microbiota
    Matteo Serino
    Institut National de la Sante et de la Recherche Medicale, Toulouse, France
    Gut 61:543-53. 2012
    ..This study investigated whether the gut microbiota per se, aside from changes in genetic background and diet, could sign different metabolic phenotypes in mice...
  14. pmc Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment
    Jacques Amar
    Rangueil Hospital, Department of Therapeutics, Toulouse, France
    EMBO Mol Med 3:559-72. 2011
    ....
  15. pmc Resveratrol increases glucose induced GLP-1 secretion in mice: a mechanism which contributes to the glycemic control
    Thi Mai Anh Dao
    Institut National de la Santé et de la Recherche Médicale U1048, Institut de recherche sur les Maladies Métaboliques et Cardiovasculaire, I2MC, Toulouse, France
    PLoS ONE 6:e20700. 2011
    ..In addition, RSV treatment modified gut microbiota and decreased the inflammatory status of mice. Our data suggest that RSV exerts its actions in part through modulation of the enteroendocrine axis in vivo...
  16. ncbi request reprint Microbes on-air: gut and tissue microbiota as targets in type 2 diabetes
    Matteo Serino
    Institut National de la Santé et de Recherche Médicale INSERM, Toulouse, France
    J Clin Gastroenterol 46:S27-8. 2012
    ..Altogether, our results confirm the presence of gut microbes and propose tissue microbiota as new targets for the innovative treatment of T2D...
  17. pmc Gut microbiota and diabetes: from pathogenesis to therapeutic perspective
    Remy Burcelin
    Institut National de la Sante et de la Recherche Medicale INSERM, Toulouse, France
    Acta Diabetol 48:257-73. 2011
    ....
  18. ncbi request reprint The gut microbiota ecology: a new opportunity for the treatment of metabolic diseases?
    Remy Burcelin
    Rangueil Institute of Molecular Medicine, I2MR, U858 INSERM, IFR31, Toulouse, France
    Front Biosci (Landmark Ed) 14:5107-17. 2009
    ..Therefore, strategies aimed at controlling the ecological mutualism between intestinal microflora and the host should lead to a new era of therapeutic and health benefits...
  19. ncbi request reprint Glucagon-like peptide-1 and energy homeostasis
    Remy Burcelin
    Institute of Molecular Medicine Rangueil IMR, INSERM 858, Universite Paul Sabatier, IFR31, CHU Rangueil, Toulouse Cedex 4, France
    J Nutr 137:2534S-2538S. 2007
    ..Furthermore, recent evidence has suggested that the nervous system is a key player accounting for the beneficial role of GLP-1 on the control of energy homeostasis. Hence, the role of GLP-1 on the gut-to-brain axis is reviewed...
  20. pmc The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity
    Benoit Viollet
    Department of Genetic, Development, and Molecular Pathology, Institut National de la Sante et de la Recherche Medicale INSERM, Centre National de la Recherche Scientifique CNRS, Rene Descartes University, Paris, France
    J Clin Invest 111:91-8. 2003
    ..Therefore, extramuscular AMPKalpha2 catalytic subunit is important for whole-body insulin action in vivo, probably through modulation of sympathetic nervous activity...
  21. doi request reprint The gut-brain axis: a major glucoregulatory player
    R Burcelin
    Institut National de la Sante et de la Recherche Medicale INSERM, U858, Toulouse, France
    Diabetes Metab 36:S54-8. 2010
    ..Although not yet fully demonstrated, GLP-1-based therapies regulate glucose sensors, which leads to the glycaemic improvement. Certainly other molecular targets could be identified to further generate new therapeutic strategies...
  22. doi request reprint GLP-1: what is known, new and controversial in 2010?
    R Burcelin
    Institut national de la santé et de la recherche médicale INSERM U858, Toulouse, France
    Diabetes Metab 36:503-9. 2010
    ..Although still considered speculative, these perspectives remain hopeful and promising...
  23. ncbi request reprint Physiological role of AMP-activated protein kinase (AMPK): insights from knockout mouse models
    B Viollet
    Institut Cochin, Dpt GDPM, 24 Rue du Faubourg Saint Jacques 75014 Paris, France
    Biochem Soc Trans 31:216-9. 2003
    ..We suggest that the alpha2 catalytic subunit of AMPK plays a major role as a fuel sensor by modulating the activity of the autonomous nervous system in vivo...
  24. doi request reprint Intestinal microflora and metabolic diseases
    M Serino
    Institut National de la Sante et de la Recherche Medicale, Toulouse, France
    Diabetes Metab 35:262-72. 2009
    ..What now remains is to demonstrate the molecular connection between the intestinal microflora and metabolic diseases. We propose here that the proinflammatory lipopolysaccharides play a causal role in the onset of metabolic disorders...
  25. pmc Blood microbiota dysbiosis is associated with the onset of cardiovascular events in a large general population: the D.E.S.I.R. study
    Jacques Amar
    INSERM U1048, Institute of Research on Metabolic and Cardiovascular Diseases, CHU Toulouse, Toulouse, France
    PLoS ONE 8:e54461. 2013
    ..We recently described a human blood microbiome and a connection between this microbiome and the onset of diabetes. The aim of the current study was to assess the association between blood microbiota and incident cardiovascular disease...
  26. doi request reprint Regulation of metabolism: a cross talk between gut microbiota and its human host
    Remy Burcelin
    Institut National de la Sante et de la Recherche Medicale INSERM, Institut des Maladies Métaboliques et Cardiovasculaires, Toulouse, France
    Physiology (Bethesda) 27:300-7. 2012
    ....
  27. doi request reprint A role for the gut-to-brain GLP-1-dependent axis in the control of metabolism
    Remy Burcelin
    Rangueil Institute of Molecular Medicine, I 2 MR, U858 INSERM, IFR31, BP 84225, Toulouse, France
    Curr Opin Pharmacol 9:744-52. 2009
    ..These integrate and redistribute the GLP-1-dependent signals toward numerous targeted tissues. We will review some of them...
  28. pmc GLP-1, the gut-brain, and brain-periphery axes
    Cendrine Cabou
    INSERM Institut National de la Santé et de la Recherche Médicale, U1048, Institute of Metabolic and Cardiovascular Diseases Rangueil, University of Toulouse III Paul Sabatier, Toulouse, France
    Rev Diabet Stud 8:418-31. 2011
    ..This pleiotropic action of GLP-1 is an important concept that may help to explain the observation that, during their treatment, type 2 diabetic patients can be identified as 'responders' and 'non-responders'...
  29. ncbi request reprint Central insulin regulates heart rate and arterial blood flow: an endothelial nitric oxide synthase-dependent mechanism altered during diabetes
    Cendrine Cabou
    INSERM U858, Institute of Molecular Medicine, IFR31, CHU Rangueil, BP 84225, 31432 Toulouse Cedex 4, France
    Diabetes 56:2872-7. 2007
    ..Its role in the central nervous system remains to be determined. We studied the effects of central insulin infusion on femoral arterial blood flow and heart rate in normal chow-fed, high-fat diet-fed diabetic, and eNOS-null mice...
  30. doi request reprint GLP-1-based strategies: a physiological analysis of differential mode of action
    Remy Burcelin
    INSERM U1048, Institut des Maladies Métaboliques et Cardiovasculaires, Universite de Toulouse, Toulouse, France
    Physiology (Bethesda) 29:108-21. 2014
    ....
  31. pmc The gut microbiota profile is associated with insulin action in humans
    Matteo Serino
    Institut National de la Sante et de la Recherche Medicale INSERM, Toulouse, France
    Acta Diabetol 50:753-61. 2013
    ..We conclude that a specific gut microbial profile is associated with insulin action in humans. ..
  32. pmc Partial inhibition of adipose tissue lipolysis improves glucose metabolism and insulin sensitivity without alteration of fat mass
    Amandine Girousse
    INSERM, UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France University of Toulouse, UMR1048, Paul Sabatier University, France
    PLoS Biol 11:e1001485. 2013
    ..Thus, reduction in WAT lipolysis reshapes FA fluxes without increase of fat mass and improves glucose metabolism through cell-autonomous induction of fat cell de novo lipogenesis, which contributes to improved insulin sensitivity...
  33. ncbi request reprint Apelin stimulates glucose utilization in normal and obese insulin-resistant mice
    Cedric Dray
    Institut National de la Sante et de la Recherche Medicale, U858, Toulouse, France
    Cell Metab 8:437-45. 2008
    ..Remarkably, in obese and insulin-resistant mice, apelin restored glucose tolerance and increased glucose utilization. Apelin could thus represent a promising target in the management of insulin resistance...
  34. pmc PPARγ ligands switched high fat diet-induced macrophage M2b polarization toward M2a thereby improving intestinal Candida elimination
    Lise Lefevre
    UMR MD3 EA2405 Polarisation des Macrophages et Récepteurs Nucléaires dans les Pathologies Inflammatoires et Infectieuses, Universite de Toulouse III, Toulouse, France
    PLoS ONE 5:e12828. 2010
    ..In conclusion, our data demonstrate a dual benefit of PPARγ ligands because they promote mucosal defence mechanisms against GI candidiasis through M2a macrophage polarization while regulating blood glucose level...
  35. ncbi request reprint Metabolic endotoxemia initiates obesity and insulin resistance
    Patrice D Cani
    Institute of Molecular Medicine, I2MR Toulouse, France
    Diabetes 56:1761-72. 2007
    ..We conclude that the LPS/CD14 system sets the tone of insulin sensitivity and the onset of diabetes and obesity. Lowering plasma LPS concentration could be a potent strategy for the control of metabolic diseases...
  36. ncbi request reprint Energy intake is associated with endotoxemia in apparently healthy men
    Jacques Amar
    INSERM 558, Toulouse, France
    Am J Clin Nutr 87:1219-23. 2008
    ..The bridge between food intake and weight is not fully understood. Recently, the role of gut microbiota and bacterial lipopolysacharides (LPS) in weight has been noted...
  37. ncbi request reprint Influence of acute and chronic administration of benzylamine on glucose tolerance in diabetic and obese mice fed on very high-fat diet
    Z Iffiú-Soltész'
    INSERM U858, IFR 31 Rangueil, I2MR, Equipe 3, Universite Toulouse III Paul Sabatier, Toulouse, France
    J Physiol Biochem 63:305-15. 2007
    ....