Remy Burcelin

Summary

Country: France

Publications

  1. doi request reprint Physiological and pharmacological mechanisms through which the DPP-4 inhibitor sitagliptin regulates glycemia in mice
    Aurelie Waget
    Institut de Recherche sur les Maladies Métaboliques et Cardiovasculaires de l Hôpital Rangueil, INSERM U1048, BP 84225, 31432 Toulouse Cedex 4, France
    Endocrinology 152:3018-29. 2011
  2. pmc High-fat diet induces periodontitis in mice through lipopolysaccharides (LPS) receptor signaling: protective action of estrogens
    Vincent Blasco-Baque
    Institut National de la Sante et de la Recherche Medicale INSERM, Toulouse, France
    PLoS ONE 7:e48220. 2012
  3. pmc Resveratrol increases glucose induced GLP-1 secretion in mice: a mechanism which contributes to the glycemic control
    Thi Mai Anh Dao
    Institut National de la Santé et de la Recherche Médicale U1048, Institut de recherche sur les Maladies Métaboliques et Cardiovasculaire, I2MC, Toulouse, France
    PLoS ONE 6:e20700. 2011
  4. pmc Brain GLP-1 signaling regulates femoral artery blood flow and insulin sensitivity through hypothalamic PKC-δ
    Cendrine Cabou
    INSERM U1048, Institute of Metabolic and Cardiovascular Diseases, Rangueil, Universite Paul Sabatier, Toulouse, France
    Diabetes 60:2245-56. 2011
  5. pmc Lipid-induced peroxidation in the intestine is involved in glucose homeostasis imbalance in mice
    Matteo Serino
    Institut National de la Sante et de la Recherche Medicale, U1048, Toulouse, France
    PLoS ONE 6:e21184. 2011
  6. pmc Metabolic adaptation to a high-fat diet is associated with a change in the gut microbiota
    Matteo Serino
    Institut National de la Sante et de la Recherche Medicale, Toulouse, France
    Gut 61:543-53. 2012
  7. doi request reprint Metagenome and metabolism: the tissue microbiota hypothesis
    Remy Burcelin
    Institut National de Sante et de Recherche Medicale INSERM, U1048, Toulouse, France
    Diabetes Obes Metab 15:61-70. 2013
  8. doi request reprint Incretins: what is known, new and controversial in 2013?
    R Burcelin
    Institut national de la santé et de la recherche médicale Inserm 1048, U858, I2MC, Hopital Rangueil, BP 84225, 31432 Toulouse cedex, France
    Diabetes Metab 39:89-93. 2013
  9. doi request reprint Regulation of metabolism: a cross talk between gut microbiota and its human host
    Remy Burcelin
    Institut National de la Sante et de la Recherche Medicale INSERM, Institut des Maladies Métaboliques et Cardiovasculaires, Toulouse, France
    Physiology (Bethesda) 27:300-7. 2012
  10. doi request reprint Immuno-microbiota cross and talk: the new paradigm of metabolic diseases
    Remy Burcelin
    Institut National de la Sante et de la Recherche Medicale, U1048, Institut des Maladies Métaboliques et Cardiovasculaires I2MC, BP 84225, 31432 Toulouse, France
    Semin Immunol 24:67-74. 2012

Detail Information

Publications44

  1. doi request reprint Physiological and pharmacological mechanisms through which the DPP-4 inhibitor sitagliptin regulates glycemia in mice
    Aurelie Waget
    Institut de Recherche sur les Maladies Métaboliques et Cardiovasculaires de l Hôpital Rangueil, INSERM U1048, BP 84225, 31432 Toulouse Cedex 4, France
    Endocrinology 152:3018-29. 2011
    ....
  2. pmc High-fat diet induces periodontitis in mice through lipopolysaccharides (LPS) receptor signaling: protective action of estrogens
    Vincent Blasco-Baque
    Institut National de la Sante et de la Recherche Medicale INSERM, Toulouse, France
    PLoS ONE 7:e48220. 2012
    ..In this study, we evaluated whether diet-induced metabolic disease would favor the development of periodontitis in mice. In addition, the regulatory role of estrogens in this process was assessed...
  3. pmc Resveratrol increases glucose induced GLP-1 secretion in mice: a mechanism which contributes to the glycemic control
    Thi Mai Anh Dao
    Institut National de la Santé et de la Recherche Médicale U1048, Institut de recherche sur les Maladies Métaboliques et Cardiovasculaire, I2MC, Toulouse, France
    PLoS ONE 6:e20700. 2011
    ..In addition, RSV treatment modified gut microbiota and decreased the inflammatory status of mice. Our data suggest that RSV exerts its actions in part through modulation of the enteroendocrine axis in vivo...
  4. pmc Brain GLP-1 signaling regulates femoral artery blood flow and insulin sensitivity through hypothalamic PKC-δ
    Cendrine Cabou
    INSERM U1048, Institute of Metabolic and Cardiovascular Diseases, Rangueil, Universite Paul Sabatier, Toulouse, France
    Diabetes 60:2245-56. 2011
    ....
  5. pmc Lipid-induced peroxidation in the intestine is involved in glucose homeostasis imbalance in mice
    Matteo Serino
    Institut National de la Sante et de la Recherche Medicale, U1048, Toulouse, France
    PLoS ONE 6:e21184. 2011
    ..The study aimed at comparing the effect of Medialipid (ML) overload on insulin secretion and sensitivity when administered either through the intestine or the carotid artery in mice...
  6. pmc Metabolic adaptation to a high-fat diet is associated with a change in the gut microbiota
    Matteo Serino
    Institut National de la Sante et de la Recherche Medicale, Toulouse, France
    Gut 61:543-53. 2012
    ..This study investigated whether the gut microbiota per se, aside from changes in genetic background and diet, could sign different metabolic phenotypes in mice...
  7. doi request reprint Metagenome and metabolism: the tissue microbiota hypothesis
    Remy Burcelin
    Institut National de Sante et de Recherche Medicale INSERM, U1048, Toulouse, France
    Diabetes Obes Metab 15:61-70. 2013
    ....
  8. doi request reprint Incretins: what is known, new and controversial in 2013?
    R Burcelin
    Institut national de la santé et de la recherche médicale Inserm 1048, U858, I2MC, Hopital Rangueil, BP 84225, 31432 Toulouse cedex, France
    Diabetes Metab 39:89-93. 2013
    ..The pharmacological features distinguishing GLP-1 receptor agonists from DPP-4 inhibitors are discussed here to address their respective positions in type 2 diabetes...
  9. doi request reprint Regulation of metabolism: a cross talk between gut microbiota and its human host
    Remy Burcelin
    Institut National de la Sante et de la Recherche Medicale INSERM, Institut des Maladies Métaboliques et Cardiovasculaires, Toulouse, France
    Physiology (Bethesda) 27:300-7. 2012
    ....
  10. doi request reprint Immuno-microbiota cross and talk: the new paradigm of metabolic diseases
    Remy Burcelin
    Institut National de la Sante et de la Recherche Medicale, U1048, Institut des Maladies Métaboliques et Cardiovasculaires I2MC, BP 84225, 31432 Toulouse, France
    Semin Immunol 24:67-74. 2012
    ....
  11. doi request reprint The gut-brain axis: a major glucoregulatory player
    R Burcelin
    Institut National de la Sante et de la Recherche Medicale INSERM, U858, Toulouse, France
    Diabetes Metab 36:S54-8. 2010
    ..Although not yet fully demonstrated, GLP-1-based therapies regulate glucose sensors, which leads to the glycaemic improvement. Certainly other molecular targets could be identified to further generate new therapeutic strategies...
  12. doi request reprint GLP-1: what is known, new and controversial in 2010?
    R Burcelin
    Institut national de la santé et de la recherche médicale INSERM U858, Toulouse, France
    Diabetes Metab 36:503-9. 2010
    ..Although still considered speculative, these perspectives remain hopeful and promising...
  13. pmc Gut microbiota and diabetes: from pathogenesis to therapeutic perspective
    Remy Burcelin
    Institut National de la Sante et de la Recherche Medicale INSERM, Toulouse, France
    Acta Diabetol 48:257-73. 2011
    ....
  14. ncbi request reprint A role for the gut-to-brain GLP-1-dependent axis in the control of metabolism
    Remy Burcelin
    Rangueil Institute of Molecular Medicine, I 2 MR, U858 INSERM, IFR31, BP 84225, Toulouse, France
    Curr Opin Pharmacol 9:744-52. 2009
    ..These integrate and redistribute the GLP-1-dependent signals toward numerous targeted tissues. We will review some of them...
  15. ncbi request reprint The gut microbiota ecology: a new opportunity for the treatment of metabolic diseases?
    Remy Burcelin
    Rangueil Institute of Molecular Medicine, I2MR, U858 INSERM, IFR31, Toulouse, France
    Front Biosci (Landmark Ed) 14:5107-17. 2009
    ..Therefore, strategies aimed at controlling the ecological mutualism between intestinal microflora and the host should lead to a new era of therapeutic and health benefits...
  16. pmc Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage
    Claude Knauf
    UMR 5018, Universite Paul Sabatier, IFR31, Toulouse, France USA
    J Clin Invest 115:3554-63. 2005
    ..Our data show that during hyperglycemia, brain GLP-1 inhibited muscle glucose utilization and increased insulin secretion to favor hepatic glycogen stores, preparing efficiently for the next fasting state...
  17. pmc Brain glucagon-like peptide-1 regulates arterial blood flow, heart rate, and insulin sensitivity
    Cendrine Cabou
    Institut National de la Sante et de la Recherche Medicale INSERM, U858, Institute of Molecular Medicine Rangueil, Toulouse, France
    Diabetes 57:2577-87. 2008
    ..GLP-1 is also produced in the brain, where its contribution to central regulation of metabolic and cardiovascular homeostasis remains incompletely understood...
  18. pmc Role of central nervous system glucagon-like Peptide-1 receptors in enteric glucose sensing
    Claude Knauf
    Institut de Medecine Moleculaire de Rangueil, Institut National de la Santé et de la Recherche Médicale U858, IFR31, Centre Hospitalier Universitaire Rangueil, Toulouse, France
    Diabetes 57:2603-12. 2008
    ..The aim of this study was to determine the cells in the brain targeted by the activation of the enteric glucose-sensing system...
  19. ncbi request reprint GLUT2 and the incretin receptors are involved in glucose-induced incretin secretion
    Patrice D Cani
    Institut de Medecine Moleculaire de Rangueil, I 2 MR, IFR31, CHU Rangueil, BP 84225, 31432 Toulouse Cedex 4, France
    Mol Cell Endocrinol 276:18-23. 2007
    ..In conclusion, both incretins secretion depends on mechanisms involving their own receptors and GLP-1 further requires GLUT2...
  20. ncbi request reprint Improvement of glucose tolerance and hepatic insulin sensitivity by oligofructose requires a functional glucagon-like peptide 1 receptor
    Patrice D Cani
    CNRS UMR 5018, University Paul Sabatier, Hopital Rangueil, 1 BP 84225, 31432 Toulouse Cedex 4, France
    Diabetes 55:1484-90. 2006
    ..In summary, our data show that the antidiabetic actions of OFS require a functional GLP-1 receptor. These findings highlight the therapeutic potential of enhancing endogenous GLP-1 secretion for the treatment of type 2 diabetes...
  21. doi request reprint Brain glucagon-like peptide 1 signaling controls the onset of high-fat diet-induced insulin resistance and reduces energy expenditure
    Claude Knauf
    Institut de Medecine Moleculaire de Rangueil, Toulouse III University, Centre Hospitalier Universitaire Rangueil, BP84225, 31432 Toulouse Cedex 4, France
    Endocrinology 149:4768-77. 2008
    ..Thus, we have demonstrated that in response to a HFD, brain GLP-1 signaling induces hyperinsulinemia and insulin resistance and decreases energy expenditure by reducing metabolic thermogenesis and ambulatory activity...
  22. pmc Prevention of obesity and insulin resistance by estrogens requires ERα activation function-2 (ERαAF-2), whereas ERαAF-1 is dispensable
    Sandra Handgraaf
    INSERM U1048, Institut des Maladies Métaboliques et Cardiovasculaires, Universite Toulouse III, Toulouse, France
    Diabetes 62:4098-108. 2013
    ....
  23. ncbi request reprint Apelin stimulates glucose utilization in normal and obese insulin-resistant mice
    Cedric Dray
    Institut National de la Sante et de la Recherche Medicale, U858, Toulouse, France
    Cell Metab 8:437-45. 2008
    ..Remarkably, in obese and insulin-resistant mice, apelin restored glucose tolerance and increased glucose utilization. Apelin could thus represent a promising target in the management of insulin resistance...
  24. ncbi request reprint Central insulin regulates heart rate and arterial blood flow: an endothelial nitric oxide synthase-dependent mechanism altered during diabetes
    Cendrine Cabou
    INSERM U858, Institute of Molecular Medicine, IFR31, CHU Rangueil, BP 84225, 31432 Toulouse Cedex 4, France
    Diabetes 56:2872-7. 2007
    ..Its role in the central nervous system remains to be determined. We studied the effects of central insulin infusion on femoral arterial blood flow and heart rate in normal chow-fed, high-fat diet-fed diabetic, and eNOS-null mice...
  25. doi request reprint [Intestinal microbiota and novel therapeutic perspectives for the treatment of metabolic diseases]
    Remy Burcelin
    Institut des Maladies Métaboliques et Cardiovasculaires, Hopital Rangueil, Toulouse Cedex, France
    Med Sci (Paris) 29:800-6. 2013
    ..Hence, individualized medicine foresees its origin within the metagenome...
  26. pmc Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment
    Jacques Amar
    Rangueil Hospital, Department of Therapeutics, Toulouse, France
    EMBO Mol Med 3:559-72. 2011
    ....
  27. ncbi request reprint Involvement of cholecystokinin 2 receptor in food intake regulation: hyperphagia and increased fat deposition in cholecystokinin 2 receptor-deficient mice
    Pascal Clerc
    Institut National de la Sante et de la Recherche Medicale Unit 531, Institut Fédératif de Recherche 31, Université de Toulouse 3, 31432 Toulouse Cedex 4, France
    Endocrinology 148:1039-49. 2007
    ..Our results give evidence that CCK2 receptor activity plays a contributing regulatory role in the control of food intake...
  28. doi request reprint Estrogens protect against high-fat diet-induced insulin resistance and glucose intolerance in mice
    Elodie Riant
    Institut National de la Santé et de la Recherche Médicale Unité 858, Institut de Medecine Moleculaire de Rangueil, Boite Postale 84225, 31432 Toulouse Cedex 4, France
    Endocrinology 150:2109-17. 2009
    ..In conclusion, the regulation of the ERalpha pathway could represent an effective strategy to reduce the impact of high-fat diet-induced type 2 diabetes...
  29. pmc Blood microbiota dysbiosis is associated with the onset of cardiovascular events in a large general population: the D.E.S.I.R. study
    Jacques Amar
    INSERM U1048, Institute of Research on Metabolic and Cardiovascular Diseases, CHU Toulouse, Toulouse, France
    PLoS ONE 8:e54461. 2013
    ..We recently described a human blood microbiome and a connection between this microbiome and the onset of diabetes. The aim of the current study was to assess the association between blood microbiota and incident cardiovascular disease...
  30. ncbi request reprint The incretins: a link between nutrients and well-being
    Remy Burcelin
    UMR 5018 CNRS UPS and IFR 31, Rangueil Hospital, Toulouse, France
    Br J Nutr 93:S147-56. 2005
    ..The control of incretin secretion represents a major goal for new therapeutic as well as nutrition strategies for treating and/or reducing the risk of hyperglycaemic syndromes, excessive body weight and thus improvement of well-being...
  31. pmc Apelin treatment increases complete Fatty Acid oxidation, mitochondrial oxidative capacity, and biogenesis in muscle of insulin-resistant mice
    Camille Attane
    INSERM U1048, Toulouse, France
    Diabetes 61:310-20. 2012
    ....
  32. pmc The gut microbiota profile is associated with insulin action in humans
    Matteo Serino
    Institut National de la Sante et de la Recherche Medicale INSERM, Toulouse, France
    Acta Diabetol 50:753-61. 2013
    ..We conclude that a specific gut microbial profile is associated with insulin action in humans. ..
  33. ncbi request reprint Energy intake is associated with endotoxemia in apparently healthy men
    Jacques Amar
    INSERM 558, Toulouse, France
    Am J Clin Nutr 87:1219-23. 2008
    ..The bridge between food intake and weight is not fully understood. Recently, the role of gut microbiota and bacterial lipopolysacharides (LPS) in weight has been noted...
  34. ncbi request reprint Changes in lipoprotein kinetics associated with type 2 diabetes affect the distribution of lipopolysaccharides among lipoproteins
    Bruno Verges
    Department of Endocrinology Diabetology B V, University Hospital, and INSERM CRI 866 B V, L D, L L, Medicine University, 21000 Dijon, France INSERM Unité 1048 C V, C G, C P, R B, Institut de Recherche sur les Maladies Métaboliques et Cardiovasculaires de Rangueil I2MC, 31432 Toulouse, France and VAIOMER SAS K B, M C, 31670 Labege, France
    J Clin Endocrinol Metab 99:E1245-53. 2014
    ..T2DM patients show lower LDL-LPS secondary to reduced VLDL catabolism, which may represent an impaired catabolic pathway. ..
  35. ncbi request reprint Microbes on-air: gut and tissue microbiota as targets in type 2 diabetes
    Matteo Serino
    Institut National de la Santé et de Recherche Médicale INSERM, Toulouse, France
    J Clin Gastroenterol 46:S27-8. 2012
    ..Altogether, our results confirm the presence of gut microbes and propose tissue microbiota as new targets for the innovative treatment of T2D...
  36. ncbi request reprint Glucagon-like peptide-1 and energy homeostasis
    Remy Burcelin
    Institute of Molecular Medicine Rangueil IMR, INSERM 858, Universite Paul Sabatier, IFR31, CHU Rangueil, Toulouse Cedex 4, France
    J Nutr 137:2534S-2538S. 2007
    ..Furthermore, recent evidence has suggested that the nervous system is a key player accounting for the beneficial role of GLP-1 on the control of energy homeostasis. Hence, the role of GLP-1 on the gut-to-brain axis is reviewed...
  37. pmc The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity
    Benoit Viollet
    Department of Genetic, Development, and Molecular Pathology, Institut National de la Sante et de la Recherche Medicale INSERM, Centre National de la Recherche Scientifique CNRS, Rene Descartes University, Paris, France
    J Clin Invest 111:91-8. 2003
    ..Therefore, extramuscular AMPKalpha2 catalytic subunit is important for whole-body insulin action in vivo, probably through modulation of sympathetic nervous activity...
  38. ncbi request reprint Intestinal MicrobiOMICS to define health and disease in human and mice
    Matteo Serino
    Universite de Toulouse, UPS, Institut des Maladies Métaboliques et Cardiovasculaires I2MC, Toulouse Cedex, France
    Curr Pharm Biotechnol 13:746-58. 2012
    ....
  39. pmc GLP-1, the gut-brain, and brain-periphery axes
    Cendrine Cabou
    INSERM Institut National de la Santé et de la Recherche Médicale, U1048, Institute of Metabolic and Cardiovascular Diseases Rangueil, University of Toulouse III Paul Sabatier, Toulouse, France
    Rev Diabet Stud 8:418-31. 2011
    ..This pleiotropic action of GLP-1 is an important concept that may help to explain the observation that, during their treatment, type 2 diabetic patients can be identified as 'responders' and 'non-responders'...
  40. ncbi request reprint Cellular and molecular mechanisms of adipose tissue plasticity in muscle insulin receptor knockout mice
    Bertrand Cariou
    Department of Endocrinology, Institut National de la Sante et de la Recherche Medicale, Unité 567 Centre National de la Recherche Scientifique, Paris, France
    Endocrinology 145:1926-32. 2004
    ..The MIRKO mouse confirms the importance of WAT plasticity in the maintenance of whole body insulin sensitivity and represents an interesting model to search for new secreted molecules that positively alter adipose tissue biology...
  41. pmc PPARγ ligands switched high fat diet-induced macrophage M2b polarization toward M2a thereby improving intestinal Candida elimination
    Lise Lefevre
    UMR MD3 EA2405 Polarisation des Macrophages et Récepteurs Nucléaires dans les Pathologies Inflammatoires et Infectieuses, Universite de Toulouse III, Toulouse, France
    PLoS ONE 5:e12828. 2010
    ..In conclusion, our data demonstrate a dual benefit of PPARγ ligands because they promote mucosal defence mechanisms against GI candidiasis through M2a macrophage polarization while regulating blood glucose level...
  42. doi request reprint Leptin and resistin: master enemy adipokines unified in brain to control glucose homeostasis
    Remy Burcelin
    Unité Mixte de Recherche 5018 Centre National de la Recherche Scientifique University Paul Sabatier, Laboratoire de Neurobiologie, Plasticite Tissulaire, et Metabolism Energetique, Toulouse, France
    Endocrinology 149:443-4. 2008
  43. doi request reprint GLP-1-based strategies: a physiological analysis of differential mode of action
    Remy Burcelin
    INSERM U1048, Institut des Maladies Métaboliques et Cardiovasculaires, Universite de Toulouse, Toulouse, France
    Physiology (Bethesda) 29:108-21. 2014
    ....
  44. pmc Partial inhibition of adipose tissue lipolysis improves glucose metabolism and insulin sensitivity without alteration of fat mass
    Amandine Girousse
    INSERM, UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France University of Toulouse, UMR1048, Paul Sabatier University, France
    PLoS Biol 11:e1001485. 2013
    ..Thus, reduction in WAT lipolysis reshapes FA fluxes without increase of fat mass and improves glucose metabolism through cell-autonomous induction of fat cell de novo lipogenesis, which contributes to improved insulin sensitivity...