Jean Francois Brunet

Summary

Country: France

Publications

  1. pmc Ancient origin of somatic and visceral neurons
    Marc Nomaksteinsky
    Institut de Biologie de l Ecole Normale Supérieure IBENS, CNRS UMR8197, Inserm U1024, Paris, France
    BMC Biol 11:53. 2013
  2. ncbi Phox2 genes - from patterning to connectivity
    Jean Francois Brunet
    CNRS UMR 8542, Ecole Normale Superieure, 46 rue d Ulm, 75005 Paris, France
    Curr Opin Genet Dev 12:435-40. 2002
  3. doi Ongoing roles of Phox2 homeodomain transcription factors during neuronal differentiation
    Eva Coppola
    Institut de Biologie de l Ecole Normale Supérieure IBENS, Paris, France
    Development 137:4211-20. 2010
  4. ncbi Dynamic expression of RGS4 in the developing nervous system and regulation by the neural type-specific transcription factor Phox2b
    Nicolas Grillet
    Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8542, Departement de Biologie, Ecole Normale Superieure, 75005 Paris, France
    J Neurosci 23:10613-21. 2003
  5. doi Defective respiratory rhythmogenesis and loss of central chemosensitivity in Phox2b mutants targeting retrotrapezoid nucleus neurons
    Veronique Dubreuil
    Departement de Biologie, Ecole Normale Superieure, 75005 Paris, France
    J Neurosci 29:14836-46. 2009
  6. ncbi Ascl1/Mash1 is required for the development of central serotonergic neurons
    Alexandre Pattyn
    CNRS UMR 8542, Ecole Normale Superieure, 75005 Paris, France
    Nat Neurosci 7:589-95. 2004
  7. pmc Epibranchial ganglia orchestrate the development of the cranial neurogenic crest
    Eva Coppola
    Institut de Biologie de l Ecole Normale Supérieure, Centre National de la Recherche Scientifique UMR8197, Institut National de la Santé et de la Recherche Médicale U1024, 75005 Paris, France
    Proc Natl Acad Sci U S A 107:2066-71. 2010
  8. ncbi Molecular consequences of PHOX2B missense, frameshift and alanine expansion mutations leading to autonomic dysfunction
    Delphine Trochet
    Universite Paris Descartes, Faculté de Médecine INSERM AP HP, Hopital Necker Enfants Malades, INSERM U 393, Paris, France
    Hum Mol Genet 14:3697-708. 2005
  9. doi Phox2b, congenital central hypoventilation syndrome and the control of respiration
    Christo Goridis
    Institut de Biologie de l Ecole Normale Supérieure IBENS, Paris, France
    Semin Cell Dev Biol 21:814-22. 2010
  10. ncbi Forced expression of Phox2 homeodomain transcription factors induces a branchio-visceromotor axonal phenotype
    Marie Rose Hirsch
    CNRS UMR 8542 Ecole normale supérieure, 46 rue d Ulm, 75005 Paris, France
    Dev Biol 303:687-702. 2007

Collaborators

Detail Information

Publications22

  1. pmc Ancient origin of somatic and visceral neurons
    Marc Nomaksteinsky
    Institut de Biologie de l Ecole Normale Supérieure IBENS, CNRS UMR8197, Inserm U1024, Paris, France
    BMC Biol 11:53. 2013
    ....
  2. ncbi Phox2 genes - from patterning to connectivity
    Jean Francois Brunet
    CNRS UMR 8542, Ecole Normale Superieure, 46 rue d Ulm, 75005 Paris, France
    Curr Opin Genet Dev 12:435-40. 2002
    ....
  3. doi Ongoing roles of Phox2 homeodomain transcription factors during neuronal differentiation
    Eva Coppola
    Institut de Biologie de l Ecole Normale Supérieure IBENS, Paris, France
    Development 137:4211-20. 2010
    ....
  4. ncbi Dynamic expression of RGS4 in the developing nervous system and regulation by the neural type-specific transcription factor Phox2b
    Nicolas Grillet
    Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8542, Departement de Biologie, Ecole Normale Superieure, 75005 Paris, France
    J Neurosci 23:10613-21. 2003
    ..Altogether, these data identify components of the heterotrimeric G-protein signaling pathway as part of the type-specific program of neuronal differentiation...
  5. doi Defective respiratory rhythmogenesis and loss of central chemosensitivity in Phox2b mutants targeting retrotrapezoid nucleus neurons
    Veronique Dubreuil
    Departement de Biologie, Ecole Normale Superieure, 75005 Paris, France
    J Neurosci 29:14836-46. 2009
    ..Together, our results provide genetic evidence for the essential role of the Phox2b-expressing RTN neurons both in establishing a normal respiratory rhythm before birth and in providing chemosensory drive...
  6. ncbi Ascl1/Mash1 is required for the development of central serotonergic neurons
    Alexandre Pattyn
    CNRS UMR 8542, Ecole Normale Superieure, 75005 Paris, France
    Nat Neurosci 7:589-95. 2004
    ..Thus Ascl1, which is essential for noradrenergic differentiation, is also a determinant of the serotonergic phenotype...
  7. pmc Epibranchial ganglia orchestrate the development of the cranial neurogenic crest
    Eva Coppola
    Institut de Biologie de l Ecole Normale Supérieure, Centre National de la Recherche Scientifique UMR8197, Institut National de la Santé et de la Recherche Médicale U1024, 75005 Paris, France
    Proc Natl Acad Sci U S A 107:2066-71. 2010
    ....
  8. ncbi Molecular consequences of PHOX2B missense, frameshift and alanine expansion mutations leading to autonomic dysfunction
    Delphine Trochet
    Universite Paris Descartes, Faculté de Médecine INSERM AP HP, Hopital Necker Enfants Malades, INSERM U 393, Paris, France
    Hum Mol Genet 14:3697-708. 2005
    ..Such a tendency to protein misfolding could explain loss of transactivation for alanine expansion mutations. However, additional mechanisms such as toxic gain-of-function may play a role in the pathogenic process...
  9. doi Phox2b, congenital central hypoventilation syndrome and the control of respiration
    Christo Goridis
    Institut de Biologie de l Ecole Normale Supérieure IBENS, Paris, France
    Semin Cell Dev Biol 21:814-22. 2010
    ..Such knowledge will enable new genetic approaches towards elucidating how respiratory networks are assembled and configured in normal and pathological conditions...
  10. ncbi Forced expression of Phox2 homeodomain transcription factors induces a branchio-visceromotor axonal phenotype
    Marie Rose Hirsch
    CNRS UMR 8542 Ecole normale supérieure, 46 rue d Ulm, 75005 Paris, France
    Dev Biol 303:687-702. 2007
    ..Hence, Phox2 expression is a key step in determining the peripheral axonal phenotype and thus the decision to stay within the neural tube or to project out of it...
  11. pmc Generation and characterization of Rgs4 mutant mice
    Nicolas Grillet
    CNRS UMR 8542, Department of Biology, Ecole Normale Superieure, 46 rue d Ulm, 75005, Paris, France
    Mol Cell Biol 25:4221-8. 2005
    ....
  12. ncbi Delays in neuronal differentiation in Mash1/Ascl1 mutants
    Alexandre Pattyn
    CNRS UMR 8542, Departement de Biologie, Ecole Normale Superieure, 75005 Paris, France
    Dev Biol 295:67-75. 2006
    ..Finally, we provide evidence that the acceleration imposed by Mash1, regardless of the production of post-mitotic cells, affects differentiation itself, both generic and type-specific...
  13. ncbi Phox2b expression in the taste centers of fish
    Eva Coppola
    Ecole Normale Superieure, Institut de Biologie de l Ecole Normale Supérieure, Paris F 75005, France
    J Comp Neurol 520:3633-49. 2012
    ....
  14. pmc Precraniate origin of cranial motoneurons
    Héloïse D Dufour
    Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8542, Ecole Normale Superieure, 46 rue d Ulm, 75005 Paris, France
    Proc Natl Acad Sci U S A 103:8727-32. 2006
    ..These data unveil that the postmetamorphic ascidian brain, assumed to be a derived feature, in fact corresponds to the vertebrate hindbrain and push back the evolutionary origin of cranial nerves to before the origin of craniates...
  15. doi In Vitro studies of non poly alanine PHOX2B mutations argue against a loss-of-function mechanism for congenital central hypoventilation
    Delphine Trochet
    INSERM U781 et Département de Génétique, Hopital Necker Enfants Malades, Universite Paris Descartes, Faculte de Medecine, Assistance Publique Hopitaux de Paris AP HP, Paris, France
    Hum Mutat 30:E421-31. 2009
    ..Therefore, PHOX2B misfolding is not the only mechanism leading to dysfunction of the ventilatory autonomic system...
  16. pmc Breathing with phox2b
    Veronique Dubreuil
    Ecole Normale Superieure, Departement de Biologie, 75005 Paris, France
    Philos Trans R Soc Lond B Biol Sci 364:2477-83. 2009
    ..Together with the previously established Phox2b dependency of other respiratory neurons (which we review briefly here), our new data highlight a key role of this transcription factor in setting up the circuits for breathing automaticity...
  17. pmc A human mutation in Phox2b causes lack of CO2 chemosensitivity, fatal central apnea, and specific loss of parafacial neurons
    Veronique Dubreuil
    Ecole Normale Superieure, Departement de Biologie, 75005 Paris, France
    Proc Natl Acad Sci U S A 105:1067-72. 2008
    ....
  18. doi PHOX2B in respiratory control: lessons from congenital central hypoventilation syndrome and its mouse models
    Jeanne Amiel
    INSERM U781, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France
    Respir Physiol Neurobiol 168:125-32. 2009
    ..To date, the reason for the selective vulnerability of RTN/pFRG neurons to PHOX2B protein dysfunction remains unexplained...
  19. doi Central chemoreception: lessons from mouse and human genetics
    Christo Goridis
    Institut de Biologie de l Ecole Normale Supérieure IBENS, Paris, France
    Respir Physiol Neurobiol 173:312-21. 2010
    ....
  20. ncbi The role of Phox2b in synchronizing pan-neuronal and type-specific aspects of neurogenesis
    Veronique Dubreuil
    CNRS UMR 8542, Departement de Biologie, Ecole Normale Superieure, 46, rue d Ulm, 75230 Paris Cedex 05, France
    Development 129:5241-53. 2002
    ..These results provide insights into the mechanisms by which a homeodomain transcription factor through interaction with other factors controls both generic and type-specific features of neuronal differentiation...
  21. pmc A Phox2b::FLPo transgenic mouse line suitable for intersectional genetics
    Marie Rose Hirsch
    Institut de Biologie de l Ecole Normale Supérieure IBENS, CNRS UMR8197, Inserm U1024, 75005, Paris, France
    Genesis 51:506-14. 2013
    ....
  22. doi Centralization of the deuterostome nervous system predates chordates
    Marc Nomaksteinsky
    Department of Biology, Ecole Normale Superieure, 75005 Paris, France CNRS UMR 8542, 75005 Paris, France
    Curr Biol 19:1264-9. 2009
    ..These neuroanatomical features, whatever their homologies with the chordate CNS, imply that nervous system centralization predates the evolutionary separation of chordate and hemichordate lineages...