E Bruckert

..Finally, translating results of recent trials in clinical practice remains a challenge for treating physicians who face poor compliance and difficulties in implementing diet in patients...

..To determine the specific features of representations of cholesterol and hypercholesterolemia according to the educational level (EL) and gender among hypercholesterolemic (HC) subjects...

..Furthermore immunization with recombinant heat shock protein-65-rich mycobacterium tuberculosis increased atherogenesis in hypercholesterolemic animal models...

..IMPORTANCE OF DIET: Finally, translating results of recent trials in clinical practice remains a challenge for treating physicians who face poor compliance and difficulties in implementing diet in patients...

..In addition, advances in our understanding of the pathophysiology of dyslipidaemia have enabled other novel therapeutic targets to be identified and studies with experimental drugs underscore the potential of these approaches...

..Subjects with severe hypothyroidism have a tendency toward increased fibrinolytic activity, and these modifications may participate to the bleeding tendency observed in such patients...

..Patients displaying overt and subclinical hypothyroidism have more cardiovascular risk factors. Consequently, they are more likely to develop atherosclerosis and cardiovascular diseases...

..Furthermore, this pooled analysis supports the use of fluvastatin to lower cholesterol levels in older high-risk patients...

..To characterize the risk factors, rate of occurrence, onset, nature and impact of mild to moderate muscular symptoms with high-dosage HMG-CoA reductase inhibitor (statin) therapy in general practice...

..The main objective was to obtain a reliable estimation of the prevalence of low HDL (< 1.03 mmol/L [< 40 mg/dL] in men; < 1.29 mmol/L [< 50 mg/dL] in women)...

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..Studies with experimental drugs have already demonstrated the potential of these approaches...

..We conclude that the relationships between triglyceride levels and FVIIc, as well as PAI-1, are continuous without threshold value of triglycerides...

..89). Adjusted odds ratios were found to be weaker when homocysteine tertiles were compared. Our data suggest that plasma total cysteine is a risk factor for atherosclerosis in hyperlipidemic patients...

..The reduced production and serum concentrations after weight loss could play a role in the improved sensitivity to insulin observed in these patients...

..Body mass index and other markers of the metabolic syndrome (HDL cholesterol, triglycerides, diabetes, and high blood pressure) are significant determinants of CRP levels in this population...

..To determine whether changes in subcutaneous adipose tissue plasminogen activator inhibitor-1 (PAI-1) expression influence plasma PAI-1 level during weight loss in obese humans...

..These results are consistent with our previous findings of a tendency to a more coagulable state in patients with normal-low FT4 levels compared with those with normal-high FT4 levels...

..We compared the effect of a statin and a fibrate (atorvastatin and fenofibrate) on plasma levels of homocysteine and other thiol compounds in hyperlipidemic patients...

..We conclude that the combination of clinical, electrical, and echographic data facilitates cost-effective noninvasive detection of CAD in asymptomatic hypercholesterolemic patients...

..We aimed to examine LDL size variation in relation to androgens and other risk factors in women with PCOS...

..However, the clinical consequences of the transient decrease of the fibrinolytic activity during the course of TSH normalization need further studies...

..5 kg), this result supports the emerging concept that adipose tissue can produce significant amounts of sTNFR-I and that this production can be modified by weight loss in human obesity...

..The aim of our study was to evaluate potential confounders, which may contribute to putative cardioprotection by alcohol...

..The clinical repercussion of studies of prevention involving a single lipid factor is probably partially due to the reduction in progression and anatomical regression of the atherosclerotic plaque.(ABSTRACT TRUNCATED AT 250 WORDS)..

..The reliability of this test to identify SAS has not been studied in patients with MS...

..This effect seems to be independent of the hormonal changes observed during weight loss...

..We conclude that phytosterol-enriched spread is a useful adjunctive therapy for hypercholesterolemic patients...

..The influence of recently developed compounds, anti-CD20, CTLA-4 Ig or anti-IL6 is not well documented. Anti-IL6 seem to increase total and LDL-cholesterol; however these changes are associated with an improvement in the TC/HDL-C ratio...

..To evaluate the influence of hospitalization on drug prescription in chronic conditions...

..Treatment should therefore be reserved for sever forms of hyperlipidemia, taking into consideration the life expectancy of the individual...

..Whether these biological abnormalities translate into increase intima remodelling and atherosclerosis remains to be studied...

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..This review presents recent data that could contribute to use of these markers for the diagnosis and the evolution of atherosclerosis. in clinical practice...

..The authors review the epidemiological evidence and the mechanisms underlying the association between infraclinical hypothyroidism and cardiovascular risk and the therapeutic implications of this association...

..Gene therapy is a promising perspective. Lovastatin and 4-phenlbutyrate have recently been shown to normalize plasma VLCFA levels. Their therapeutic efficacy must be assessed in a randomized trial...

..In clinical practice, KD patients are often misdiagnosed as having amyotrophic lateral sclerosis. Careful examination of the endocrine component could avoid such a deleterious misdiagnosis...

..The objective of this study was to assess clinical practices based on these recommendations in a department of endocrinology specialized in the management of dyslipidemic patients...

..The present study aimed to gather relevant information and investigate social determinants of dietary compliance...

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..The objective of this study was to explore physicians' perceptions of the obesity status of their patients in comparison with objective measurements of generalised or abdominal obesity...

..This review highlights the structures of MMPs and their physiological inhibitors, the Tissue Inhibitors of MMPs (TIMPs), and describes the current developments in pharmacological MMP inhibition...

..In the discussion, we stress the need to detect these very aggressive tumors as early as possible and identify treatments to improve the dramatic course of these carcinomas...

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..Flushing may occur in 80% of treated patients. Two CETP inhibitors have shown therapeutical efficacy to raise HDL cholesterol, but clinical benefit remains uncertain...

..It is impossible to perform liver biopsy in such a large number of hyperlipidaemic patients to identify patients with advanced liver fibrosis or with steatohepatitis (non-alcoholic steatohepatitis, NASH)...

..Thus, the hypothesis of cross-reaction between antithyroid antibodies and platelet epitopes, which has been proposed to explain the association, seems unlikely...

..We report a case of AAH following a sepsis, resulting in persistant adrenal insufficiency contrasting with the radiologic normalisation of the adrenals on computed tomography (CT) scan imaging...

..Because these abnormalities may not only be reversible but also associated with a poor prognosis, further studies are needed to identify those dyslipidemic patients who are at risk for the development of severe hepatic tissue damage...

..This study emphasizes the point that metabolically as well as clinically pure hypertriglyceridaemia is a very heterogeneous metabolic abnormality, as shown by its repercussions on the vascular system...

..To measure the prevalence of low high-density lipoprotein (HDL)-cholesterol (men < 1.03 mmol/l; women < 1.29 mmol/l) in European Type 2 diabetic patients receiving treatment for dyslipidaemia...

..However, further studies are highly encouraged to examine the CV benefit of PS enriched food...

..Despite these epidemiological data, the measurement of serum triglyceride levels remains important in patients with hyperlipidemia...

..Patients with very low HDL-c need a thorough evaluation by specialist physicians. Statins are associated with a modest increase of HDL-c (5%) while fibrates and nicotinic acid increase HDL-c by 10% and 20% respectively...

..We conclude that transaminase increase is encountered in the vast majority of patients treated with Mitotane. Levels at which the drug should be withdrawn remain to be established...

..Study of the GH/IGF axis activity and of its correlation with atherosclerosis opens new perspectives in the understanding of the role of this axis in cardiovascular diseases...

..In conclusion, the administration of octreotide over a three month period to acromegalic patients is associated with a decrease in TG levels...

..In contrast, APOE plasma levels were correlated with both rate of deterioration and survival time and appeared to be an important risk factor for decreased survival time with a relative risk of 0.647 (95% CI: 0.465 to 0.901; p = 0.01)...

..We compared the circulating thiol profile in a cohort of patients displaying atherogenic dyslipidemia with and without MS...

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..Such elevations might reflect enhanced vascular matrix remodeling, a key feature of the progression of atherosclerotic disease...

..Plant sterol (PS)-enriched foods have been shown to reduce plasma LDL-cholesterol concentrations. In most studies, however, PSs were incorporated into food products of high fat content...

..We evaluated serum PAPP-A levels as a marker of the premature development of atherosclerosis in hyperlipidemic subjects at elevated cardiovascular risk...

..The patients' opinion concerning the severity and evolution of their health problem, as well as the use and duration of their treatment, are, in this context, essential...

..Ezetimibe provides a new, complementary pharmacological approach for this high-risk population...

..In conclusion, increased IL-6 production by sc adipose cells might participate to the insulin-resistant state observed in human obesity...

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..This analysis helps to identify appropriate educational objectives and methods for patients at risk of cardiovascular disease, and develop a structured educational programme...

..Although FH is monogenic, wide variation occurs in the onset and severity of atherosclerosis in these patients...

..To describe the relative contribution of 10 created food groups to total fat intake in middle-aged subjects. The relationship of added oil and fat intake with region of residence and educational level was also assessed...

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..These findings are consistent with data obtained previously in younger recipients of fluvastatin XL 80 mg, and reinforce the safety of fluvastatin in a population at high risk of drug-drug interactions...

..The pharmacodynamic parameters for the three statins were accurately estimated. The PK/PD model developed successfully predicted the time course of the LDL-lowering effect of statins...

..This review describes the members of the MMP and TIMP families and discusses the structure, function and regulation of MMP activity; finally, pharmacological approaches to MMP inhibition are highlighted...

..Little is known about the relationship between hypercholesterolaemia and specific aetiological subtypes of brain infarction (BI)...

..Nonalcoholic steatohepatitis (NASH) is a liver disease that complicates insulin-resistant states. This trial tested the efficacy and safety of rosiglitazone, an insulin-sensitizing agent, in patients with NASH...

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..Elevated concentrations of large, CE-rich, light, and intermediate LDL subclasses (LDL1+2, LDL3) in hypercholesterolemia may therefore act as an abundant proatherogenic source of highly unstable LOOH in the arterial wall...

..We measured cystatin values in dyslipidemic patients and looked for correlations between renal function, cystatin, and metabolic syndrome...

..These results indicate that adiponutrin gene expression in humans is highly regulated by changes in energy balance...

..A spectrum of disease from myalgia to rhabdomyolysis exists as classic side-effect of lipid-lowering treatment (LLT). While myopathy has generated considerable interest, mild musculo-skeletal symptoms are poorly assessed...

..Pilot programs for screening high-risk populations have shown efficacy in detecting renal disease...

..In severe type IV hypertriglyceridemia (triglyceride levels >10 g/l), it is yet unknown whether lipoprotein lipase (LPL) differs according to the presence or not of diabetes...

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..Induction of selective increase in the circulating concentrations of dense HDL subfractions may represent an innovative therapeutic approach for the attenuation of high cardiovascular risk in MetS...

..72, P < 0.0001), whereas this relationship was not observed in men. In conclusion, HDL-C level may not represent the absolute indicator of the efficiency of the initial step of the reverse cholesterol transport...

..However, some concerns have been made about the effect of atorvastatin on HDL cholesterol levels in these patients...

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..New pharmacological strategies might help manage both abdominal obesity and its metabolic consequences...