E Bruckert

Summary

Country: France

Publications

  1. ncbi request reprint [Therapeutic and pleiotropic effects of statins in primary and secondary prevention of atherosclerosis]
    E Bruckert
    Service d Endocrinologie Métabolisme, Unité de prévention des maladies cardiovasculaires, Hopital Pitie Salpetriere, 47, 83 bld de l hôpital 75651 Paris
    Bull Acad Natl Med 185:49-60; discussion 60-2. 2001
  2. ncbi request reprint Educational level has a major impact on the representations of cholesterol: a study in 1579 hypercholesterolemic patients
    Silla M Consoli
    Department of Consultation Liaison Psychiatry, European Georges Pompidou Hospital, Assistance Publique Hospitaux de Paris, Paris, France
    Prev Med 38:323-9. 2004
  3. ncbi request reprint Carotid atherosclerosis is not related to past tuberculosis in hypercholesterolemic patients
    Philippe Giral
    Unités de Prévention Cardiovasculaire, Service d Endocrinologie Métabolisme, Groupe Hospitalier Pitie Salpetriere, France
    Atherosclerosis 190:150-5. 2007
  4. ncbi request reprint Components of the fibrinolytic system are differently altered in moderate and severe hypothyroidism
    R Chadarevian
    Service d Endocrinologie Métabolisme, Hopital Pitie Salpetriere, 75013 Paris, France
    J Clin Endocrinol Metab 86:732-7. 2001
  5. ncbi request reprint New lipid-modifying therapies
    Eric Bruckert
    Department of Endocrinology and Metabolism, Assitance Publique Hôpitaux de Paris, University Hôp ital Pitie Salpêtrière, Paris, France
    Expert Opin Investig Drugs 12:325-35. 2003
  6. ncbi request reprint Perspectives in cholesterol-lowering therapy: the role of ezetimibe, a new selective inhibitor of intestinal cholesterol absorption
    Eric Bruckert
    Service d Endocrinologie Métabolisme, AP HP, Hopital de la Pitie Salpetriere, Paris, France
    Circulation 107:3124-8. 2003
  7. ncbi request reprint New advances in lipid-modifying therapies for reducing cardiovascular risk
    Eric Bruckert
    Service d Endocrinologie Métabolisme, CHU Pitie Salpetriere, Assistance Publique, Hopitaux de Paris, Paris, France
    Cardiology 97:59-66. 2002
  8. ncbi request reprint Mild to moderate muscular symptoms with high-dosage statin therapy in hyperlipidemic patients--the PRIMO study
    Eric Bruckert
    Department of Endocrinology, Hopital de la Pitie Salpetriere, Assistance Publique Hôpitaux de Paris 83 Bd de L Hôpital, 75 013, Paris, France
    Cardiovasc Drugs Ther 19:403-14. 2005
  9. ncbi request reprint High prevalence of low HDL-cholesterol in a pan-European survey of 8545 dyslipidaemic patients
    Eric Bruckert
    Groupe Hospitalier Pitie Salpetriere, Paris, France
    Curr Med Res Opin 21:1927-34. 2005
  10. ncbi request reprint [Hyperlipidemias: new data and new concepts]
    E Bruckert
    Service d Endocrinologie Métabolisme, Hopital Pitie Salpetriere, 83, Boulevard de l Hopital, F75651 Paris
    Presse Med 30:177-81. 2001

Collaborators

Detail Information

Publications97

  1. ncbi request reprint [Therapeutic and pleiotropic effects of statins in primary and secondary prevention of atherosclerosis]
    E Bruckert
    Service d Endocrinologie Métabolisme, Unité de prévention des maladies cardiovasculaires, Hopital Pitie Salpetriere, 47, 83 bld de l hôpital 75651 Paris
    Bull Acad Natl Med 185:49-60; discussion 60-2. 2001
    ..Finally, translating results of recent trials in clinical practice remains a challenge for treating physicians who face poor compliance and difficulties in implementing diet in patients...
  2. ncbi request reprint Educational level has a major impact on the representations of cholesterol: a study in 1579 hypercholesterolemic patients
    Silla M Consoli
    Department of Consultation Liaison Psychiatry, European Georges Pompidou Hospital, Assistance Publique Hospitaux de Paris, Paris, France
    Prev Med 38:323-9. 2004
    ..To determine the specific features of representations of cholesterol and hypercholesterolemia according to the educational level (EL) and gender among hypercholesterolemic (HC) subjects...
  3. ncbi request reprint Carotid atherosclerosis is not related to past tuberculosis in hypercholesterolemic patients
    Philippe Giral
    Unités de Prévention Cardiovasculaire, Service d Endocrinologie Métabolisme, Groupe Hospitalier Pitie Salpetriere, France
    Atherosclerosis 190:150-5. 2007
    ..Furthermore immunization with recombinant heat shock protein-65-rich mycobacterium tuberculosis increased atherogenesis in hypercholesterolemic animal models...
  4. ncbi request reprint Components of the fibrinolytic system are differently altered in moderate and severe hypothyroidism
    R Chadarevian
    Service d Endocrinologie Métabolisme, Hopital Pitie Salpetriere, 75013 Paris, France
    J Clin Endocrinol Metab 86:732-7. 2001
    ..Subjects with severe hypothyroidism have a tendency toward increased fibrinolytic activity, and these modifications may participate to the bleeding tendency observed in such patients...
  5. ncbi request reprint New lipid-modifying therapies
    Eric Bruckert
    Department of Endocrinology and Metabolism, Assitance Publique Hôpitaux de Paris, University Hôp ital Pitie Salpêtrière, Paris, France
    Expert Opin Investig Drugs 12:325-35. 2003
    ..In addition, advances in our understanding of the pathophysiology of dyslipidaemia have enabled other novel therapeutic targets to be identified and studies with experimental drugs underscore the potential of these approaches...
  6. ncbi request reprint Perspectives in cholesterol-lowering therapy: the role of ezetimibe, a new selective inhibitor of intestinal cholesterol absorption
    Eric Bruckert
    Service d Endocrinologie Métabolisme, AP HP, Hopital de la Pitie Salpetriere, Paris, France
    Circulation 107:3124-8. 2003
  7. ncbi request reprint New advances in lipid-modifying therapies for reducing cardiovascular risk
    Eric Bruckert
    Service d Endocrinologie Métabolisme, CHU Pitie Salpetriere, Assistance Publique, Hopitaux de Paris, Paris, France
    Cardiology 97:59-66. 2002
    ..Studies with experimental drugs have already demonstrated the potential of these approaches...
  8. ncbi request reprint Mild to moderate muscular symptoms with high-dosage statin therapy in hyperlipidemic patients--the PRIMO study
    Eric Bruckert
    Department of Endocrinology, Hopital de la Pitie Salpetriere, Assistance Publique Hôpitaux de Paris 83 Bd de L Hôpital, 75 013, Paris, France
    Cardiovasc Drugs Ther 19:403-14. 2005
    ..To characterize the risk factors, rate of occurrence, onset, nature and impact of mild to moderate muscular symptoms with high-dosage HMG-CoA reductase inhibitor (statin) therapy in general practice...
  9. ncbi request reprint High prevalence of low HDL-cholesterol in a pan-European survey of 8545 dyslipidaemic patients
    Eric Bruckert
    Groupe Hospitalier Pitie Salpetriere, Paris, France
    Curr Med Res Opin 21:1927-34. 2005
    ..The main objective was to obtain a reliable estimation of the prevalence of low HDL (< 1.03 mmol/L [< 40 mg/dL] in men; < 1.29 mmol/L [< 50 mg/dL] in women)...
  10. ncbi request reprint [Hyperlipidemias: new data and new concepts]
    E Bruckert
    Service d Endocrinologie Métabolisme, Hopital Pitie Salpetriere, 83, Boulevard de l Hopital, F75651 Paris
    Presse Med 30:177-81. 2001
    ..Drug therapy has been simplified with targets tailored to the patient's risk...
  11. ncbi request reprint Comparison of efficacy and safety assessment of fluvastatin in patients <65 years versus > or =65 years of age
    Eric Bruckert
    Endocrinology Department, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Paris, France
    Am J Cardiol 96:1142-8. 2005
    ..Furthermore, this pooled analysis supports the use of fluvastatin to lower cholesterol levels in older high-risk patients...
  12. ncbi request reprint Blood lipid and lipoprotein levels: relationships with educational level and region of residence in the French SU.VI.MAX study
    E Bruckert
    Service d Endocrinologie Métabolisme, AP HP, Hopital Pitie Salpetriere, 83 Boulevard de l hopital, 75013 Paris, France
    Prev Med 40:803-11. 2005
    ....
  13. ncbi request reprint Low free-thyroxine levels are a risk factor for subclinical atherosclerosis in euthyroid hyperlipidemic patients
    E Bruckert
    Service d Endocrinologie Métabolisme, Hopital Pitie Salpetriere, Paris, France
    J Cardiovasc Risk 6:327-31. 1999
    ..Patients displaying overt and subclinical hypothyroidism have more cardiovascular risk factors. Consequently, they are more likely to develop atherosclerosis and cardiovascular diseases...
  14. ncbi request reprint Cysteine is a cardiovascular risk factor in hyperlipidemic patients
    N Jacob
    Laboratory of Biochemistry C, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Atherosclerosis 146:53-9. 1999
    ..89). Adjusted odds ratios were found to be weaker when homocysteine tertiles were compared. Our data suggest that plasma total cysteine is a risk factor for atherosclerosis in hyperlipidemic patients...
  15. ncbi request reprint Relationship between triglycerides and factor VIIc and plasminogen activator inhibitor type-1: lack of threshold value
    R Chadarevian
    Department of Endocrinology, Hopital Pitie Salpetriere, Paris, France
    Thromb Res 96:175-82. 1999
    ..We conclude that the relationships between triglyceride levels and FVIIc, as well as PAI-1, are continuous without threshold value of triglycerides...
  16. ncbi request reprint Elevated C-reactive protein constitutes an independent predictor of advanced carotid plaques in dyslipidemic subjects
    R Blackburn
    , Paris, France
    Arterioscler Thromb Vasc Biol 21:1962-8. 2001
    ..Body mass index and other markers of the metabolic syndrome (HDL cholesterol, triglycerides, diabetes, and high blood pressure) are significant determinants of CRP levels in this population...
  17. ncbi request reprint Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss
    J P Bastard
    Service de Biochimie, Hopital de la Salpetriere, Paris, France
    J Clin Endocrinol Metab 85:3338-42. 2000
    ..The reduced production and serum concentrations after weight loss could play a role in the improved sensitivity to insulin observed in these patients...
  18. ncbi request reprint Subcutaneous adipose tissue expression of plasminogen activator inhibitor-1 gene during very low calorie diet in obese subjects
    J P Bastard
    Service de Biochimie, Hopital de la Salpetriere, AP HP, Paris
    Int J Obes Relat Metab Disord 24:70-4. 2000
    ..To determine whether changes in subcutaneous adipose tissue plasminogen activator inhibitor-1 (PAI-1) expression influence plasma PAI-1 level during weight loss in obese humans...
  19. doi request reprint Discontinuation of statin therapy due to muscular side effects: a survey in real life
    D Rosenbaum
    Unite de prevention cardiovasculaire, Service d Endocrinologie Métabolisme, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, France UPMC université Paris 06, UMR S 939, F 75013, France Electronic address
    Nutr Metab Cardiovasc Dis 23:871-5. 2013
    ..To assess the burden of statin related muscular symptom in real life...
  20. ncbi request reprint Relationship between thyroid hormones and fibrinogen levels
    R Chadarevian
    Hopital Pitie Salpetriere, Paris, France
    Blood Coagul Fibrinolysis 10:481-6. 1999
    ..These results are consistent with our previous findings of a tendency to a more coagulable state in patients with normal-low FT4 levels compared with those with normal-high FT4 levels...
  21. ncbi request reprint Variations in plasma soluble tumour necrosis factor receptors after diet-induced weight loss in obesity
    J P Bastard
    Service de Biochimie, H pital de la Salpêtrière, Paris, France
    Diabetes Obes Metab 2:323-5. 2000
    ..5 kg), this result supports the emerging concept that adipose tissue can produce significant amounts of sTNFR-I and that this production can be modified by weight loss in human obesity...
  22. ncbi request reprint Smaller LDL particle size in women with polycystic ovary syndrome compared to controls
    S Dejager
    Service d endocrinologie, La Pitié Salpêtrière, Paris, France
    Clin Endocrinol (Oxf) 54:455-62. 2001
    ..We aimed to examine LDL size variation in relation to androgens and other risk factors in women with PCOS...
  23. ncbi request reprint Effect of levothyroxine replacement therapy on coagulation and fibrinolysis in severe hypothyroidism
    R Chadarevian
    Service d Endocrinologie Métabolisme, Hopital Pitie Salpetriere, Paris, France
    J Endocrinol Invest 28:398-404. 2005
    ..With the exception of von Willebrand type 1 disease, reversibility of hemostatic changes is not established after levothyroxine replacement therapy. Therefore our objective was to analyze the reversibility of these anomalies...
  24. ncbi request reprint Homocysteine and lipid lowering agents. A comparison between atorvastatin and fenofibrate in patients with mixed hyperlipidemia
    P Giral
    Service d Endocrinologie Métabolisme, Centre de Détection et de Prévention de l Athérosclérose, Groupe Hospitalier Pitié, Salpetriere, 47 83 boulevard de l Hopital, 75651 Cedex 13, Paris, France
    Atherosclerosis 154:421-7. 2001
    ..We compared the effect of a statin and a fibrate (atorvastatin and fenofibrate) on plasma levels of homocysteine and other thiol compounds in hyperlipidemic patients...
  25. ncbi request reprint Usefulness in predicting coronary artery disease by ultrasonic evaluation of the carotid arteries in asymptomatic hypercholesterolemic patients with positive exercise stress tests
    P Giral
    Service d Endocrinologie Métabolisme, Groupe Hospitalier Pitie Salpetriere, Universite Pierre et Marie Curie, Paris, France
    Am J Cardiol 84:14-7. 1999
    ..We conclude that the combination of clinical, electrical, and echographic data facilitates cost-effective noninvasive detection of CAD in asymptomatic hypercholesterolemic patients...
  26. ncbi request reprint Relationship between alcohol intake, health and social status and cardiovascular risk factors in the Urban Paris-Ile-de-France Cohort: is the cardioprotective action of alcohol a myth?
    B Hansel
    Service d Endocrinologie Métabolisme, AP HP, Hopital de la Pitie, Paris, France
    Eur J Clin Nutr 64:561-8. 2010
    ..The aim of our study was to evaluate potential confounders, which may contribute to putative cardioprotection by alcohol...
  27. doi request reprint [Lipid profile and cardiovascular risk in patients with rheumatoid arthritis: Effect of the disease and of drug therapy]
    B Hansel
    Service d endocrinologie métabolisme et de prévention cardiovasculaire, Hopital de la Pitie Salpetriere, 47 83, Boulevard de l Hopital, 75013 Paris, France
    Ann Endocrinol (Paris) 71:257-63. 2010
    ..The influence of recently developed compounds, anti-CD20, CTLA-4 Ig or anti-IL6 is not well documented. Anti-IL6 seem to increase total and LDL-cholesterol; however these changes are associated with an improvement in the TC/HDL-C ratio...
  28. ncbi request reprint [Prevalence of sleep apnea in men with metabolic syndrome and controlled hypertension]
    B Hansel
    Service d endocrinologie métabolisme et de prévention cardiovasculaire, Hopital de la Pitie Salpetriere, Paris
    Arch Mal Coeur Vaiss 100:637-41. 2007
    ..The reliability of this test to identify SAS has not been studied in patients with MS...
  29. ncbi request reprint Plant sterol-enriched margarine lowers plasma LDL in hyperlipidemic subjects with low cholesterol intake: effect of fibrate treatment
    F Nigon
    , , Paris, France
    Clin Chem Lab Med 39:634-40. 2001
    ..We conclude that phytosterol-enriched spread is a useful adjunctive therapy for hypercholesterolemic patients...
  30. ncbi request reprint Changes in lipoprotein(a) levels and hormonal correlations during a weight reduction program
    D N Kiortsis
    Department of Endocrinology, , Paris, France
    Nutr Metab Cardiovasc Dis 11:153-7. 2001
    ..This effect seems to be independent of the hormonal changes observed during weight loss...
  31. doi request reprint [Influence of hospitalisation on drug prescription in arterial hypertension and chronic conditions]
    P Hindlet
    Service de Pharmacie, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, 75013 Paris, France
    Ann Cardiol Angeiol (Paris) 61:224-8. 2012
    ..To evaluate the influence of hospitalization on drug prescription in chronic conditions...
  32. ncbi request reprint [Hyperlipidemia in patients over 60 years old]
    E Bruckert
    Service d Endocrinologie Métabolisme, Hopital Pitie Salpetriere, Lyon
    Arch Mal Coeur Vaiss 85:79-82. 1992
    ..Treatment should therefore be reserved for sever forms of hyperlipidemia, taking into consideration the life expectancy of the individual...
  33. ncbi request reprint [New non-lipidic biological markers of atherosclerosis]
    J L Beaudeux
    Service de Biochimie C, , , AP-HP, 47-83, , 75651 Paris Cedex 13, France
    Ann Med Interne (Paris) 152:169-79. 2001
    ..This review presents recent data that could contribute to use of these markers for the diagnosis and the evolution of atherosclerosis. in clinical practice...
  34. ncbi request reprint Relationship of circulating C-reactive protein levels to thyroid status and cardiovascular risk in hyperlipidemic euthyroid subjects: low free thyroxine is associated with elevated hsCRP
    C Jublanc
    Department of Endocrinology, group hospitalier La Pitié Salpêtrière, Hopital Pitie Salpetriere, AP HP, 47 83 Boulevard de l Hôpital 75651, Paris Cedex 13, France
    Atherosclerosis 172:7-11. 2004
    ....
  35. ncbi request reprint [Role of LDL in cardiovascular diseases. New data and new recommendations]
    E Bruckert
    Unité d exploration métabolique pour la prévention des maladies cardiovasculaires, Hopital Pitie Salpetriere, Paris 75, France
    Presse Med 34:249-55. 2005
    ..In this perspective, therapeutic education is one of the tools that would promote compliance. New treatments in the field of HDL would further support the progress made in such prevention...
  36. doi request reprint Serum levels of adhesion molecules ICAM-1 and VCAM-1 and tissue inhibitor of metalloproteinases, TIMP-1, are elevated in patients with autoimmune thyroid disorders: relevance to vascular inflammation
    C Jublanc
    Service d Endocrinologie Métabolisme, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris AP HP, Paris, France
    Nutr Metab Cardiovasc Dis 21:817-22. 2011
    ..Whether these biological abnormalities translate into increase intima remodelling and atherosclerosis remains to be studied...
  37. ncbi request reprint [Subclinical hypothyroidism: a cardiovascular risk factor?]
    F Cohen-Aubart
    Service d Endocrinologie Métabolisme, Groupe Hospitalier La Pitié Salpêtrière, 47 83, Boulevard de l Hopital, 75013 Paris
    Arch Mal Coeur Vaiss 100:213-6. 2007
    ..The authors review the epidemiological evidence and the mechanisms underlying the association between infraclinical hypothyroidism and cardiovascular risk and the therapeutic implications of this association...
  38. ncbi request reprint A comprehensive endocrine description of Kennedy's disease revealing androgen insensitivity linked to CAG repeat length
    S Dejager
    Department of Endocrinology, Hopital de la Pitie Salpetriere, Assistance Publique Hopitaux de Paris, France
    J Clin Endocrinol Metab 87:3893-901. 2002
    ..In clinical practice, KD patients are often misdiagnosed as having amyotrophic lateral sclerosis. Careful examination of the endocrine component could avoid such a deleterious misdiagnosis...
  39. ncbi request reprint [Endocrine disease in adrenoleukodystrophy]
    S Girard
    , , 83, , 75651 Paris Cedex 13
    Ann Med Interne (Paris) 152:15-26. 2001
    ..Gene therapy is a promising perspective. Lovastatin and 4-phenlbutyrate have recently been shown to normalize plasma VLCFA levels. Their therapeutic efficacy must be assessed in a randomized trial...
  40. doi request reprint [Adherence to national guidelines for lipid management in a department of endocrinology]
    F Chiche
    Service d Endocrinologie Métabolisme, Hopital de la Pitie Salpetriere, 75013 Paris, France
    Ann Endocrinol (Paris) 70:119-25. 2009
    ..The objective of this study was to assess clinical practices based on these recommendations in a department of endocrinology specialized in the management of dyslipidemic patients...
  41. ncbi request reprint Screening for liver disease using non-invasive biomarkers (FibroTest, SteatoTest and NashTest) in patients with hyperlipidaemia
    V Ratziu
    APHP Hépatologie GHPS, Paris, France
    Aliment Pharmacol Ther 25:207-18. 2007
    ..It is impossible to perform liver biopsy in such a large number of hyperlipidaemic patients to identify patients with advanced liver fibrosis or with steatohepatitis (non-alcoholic steatohepatitis, NASH)...
  42. doi request reprint The THEMA study: a sociodemographic survey of hypercholesterolaemic individuals
    T Fournier
    Universite de Toulouse, CERTOP CNRS, UTM, Toulouse, France
    J Hum Nutr Diet 24:572-81. 2011
    ..The present study aimed to gather relevant information and investigate social determinants of dietary compliance...
  43. ncbi request reprint Systemic low-grade inflammation is related to both circulating and adipose tissue TNFalpha, leptin and IL-6 levels in obese women
    M Maachi
    Service de Biochimie et Hormonologie, Hopital Tenon, AP HP, France
    Int J Obes Relat Metab Disord 28:993-7. 2004
    ..We assessed the relationships between four circulating acute phase proteins and the circulating and adipose tissue levels of three adipocytokines...
  44. ncbi request reprint Are physicians able to identify high-risk abdominally obese individuals? An analysis from the pan-European Survey of HDL-cholesterol
    M Baccara-Dinet
    CardioMetabolic Care, Merck Santé, Paris, France
    Curr Med Res Opin 23:2005-8. 2007
    ..The objective of this study was to explore physicians' perceptions of the obesity status of their patients in comparison with objective measurements of generalised or abdominal obesity...
  45. ncbi request reprint [Matrix metalloproteinases and atherosclerosis. Therapeutic aspects]
    J L Beaudeux
    Service de Biochimie C, Group Hospitalier Pitie Salpetriere, AP HP, 47 83 boulevard de l Hopital, 75651 Paris Cedex 13
    Ann Biol Clin (Paris) 61:147-58. 2003
    ..This review highlights the structures of MMPs and their physiological inhibitors, the Tissue Inhibitors of MMPs (TIMPs), and describes the current developments in pharmacological MMP inhibition...
  46. ncbi request reprint Pituitary carcinoma: report of an exceptional case and review of the literature
    C Pichard
    Department of Endocrinology, Groupe Hospitalier La Pitié Salpêtrière, Paris, France
    J Endocrinol Invest 25:65-72. 2002
    ..In the discussion, we stress the need to detect these very aggressive tumors as early as possible and identify treatments to improve the dramatic course of these carcinomas...
  47. ncbi request reprint [Is regression of atherosclerosis possible?]
    D Thomas
    Service de cardiologie, Groupe Hospitalier Pitie Salpetriere, Paris
    Arch Mal Coeur Vaiss 85:47-57. 1992
    ..The clinical repercussion of studies of prevention involving a single lipid factor is probably partially due to the reduction in progression and anatomical regression of the atherosclerotic plaque.(ABSTRACT TRUNCATED AT 250 WORDS)..
  48. ncbi request reprint A constellation of cardiovascular risk factors is associated with hepatic enzyme elevation in hyperlipidemic patients
    E Bruckert
    Department of Endocrinology, INSERM U 551 and IFR Caeur Muscle Vaisseau, Paris, France
    Metabolism 51:1071-6. 2002
    ..Because these abnormalities may not only be reversible but also associated with a poor prognosis, further studies are needed to identify those dyslipidemic patients who are at risk for the development of severe hepatic tissue damage...
  49. ncbi request reprint [Cardiovascular complications in minor endogenous hypertriglyceridemia. Study of 235 cases]
    E Bruckert
    , , Paris
    Arch Mal Coeur Vaiss 80:1587-92. 1987
    ..This study emphasizes the point that metabolically as well as clinically pure hypertriglyceridaemia is a very heterogeneous metabolic abnormality, as shown by its repercussions on the vascular system...
  50. ncbi request reprint Adrenal insufficiency after adrenal hemorrhage
    C Jublanc
    Department of Endocrinology, Groupe Hospitalier La Pitié Salpêtrière, Paris, France
    J Endocrinol Invest 27:67-9. 2004
    ..We report a case of AAH following a sepsis, resulting in persistant adrenal insufficiency contrasting with the radiologic normalisation of the adrenals on computed tomography (CT) scan imaging...
  51. ncbi request reprint [Graves' disease and autoimmune thrombocytopenic purpura: distinct outcomes of the two diseases]
    F Cohen Aubart
    Service d Endocrinologie Métabolisme, Groupe Hospitalier de la Pitié Salpêtrière, APHP, 47 83, Boulevard de l Hopital, 75013 Paris, France
    Ann Endocrinol (Paris) 68:55-7. 2007
    ..Thus, the hypothesis of cross-reaction between antithyroid antibodies and platelet epitopes, which has been proposed to explain the association, seems unlikely...
  52. ncbi request reprint [Contribution of NMR to the assessment of dyslipidemia-related cardiovascular risk]
    D Bonnefont-Rousselot
    Laboratoire de biochimie métabolique et clinique EA 3617, Faculte des Sciences Pharmaceutiques et Biologiques, Universite Paris Descartes, Paris, France
    Ann Pharm Fr 66:123-8. 2008
    ....
  53. ncbi request reprint [New insights and perspectives in the management of dyslipidemia]
    F Cohen Aubart
    Services de Pharmacologie, Hopital de la Pitie Salpetriere, APHP, 47 83, Boulevard de l Hopital, 75013 Paris, France
    Rev Med Interne 28:537-44. 2007
    ..Flushing may occur in 80% of treated patients. Two CETP inhibitors have shown therapeutical efficacy to raise HDL cholesterol, but clinical benefit remains uncertain...
  54. ncbi request reprint HDL-c is a powerful lipid predictor of cardiovascular diseases
    E Bruckert
    Institute of Endocrinology and Prevention of Cardiovascular disease, Pavillon Benjamin Delessert, Hôpital de Pitié Salpêtrière, Assistance Publique Hopitaux de Paris, Paris, France
    Int J Clin Pract 61:1905-13. 2007
    ..Patients with very low HDL-c need a thorough evaluation by specialist physicians. Statins are associated with a modest increase of HDL-c (5%) while fibrates and nicotinic acid increase HDL-c by 10% and 20% respectively...
  55. ncbi request reprint [Hepatotoxicity of a synthetic cortisol antagonist: OP'DDD (mitotane)]
    O Neuman
    , , , 75013 Paris, France
    Therapie 56:793-7. 2001
    ..We conclude that transaminase increase is encountered in the vast majority of patients treated with Mitotane. Levels at which the drug should be withdrawn remain to be established...
  56. doi request reprint [Phytosterols and atherosclerosis]
    B Hansel
    Service d endocrinologie et de prévention cardiovasculaire, Hopital de la Pitie Salpetriere, 47 83, Boulevard de l Hopital, 75013 Paris, France
    Rev Med Interne 32:124-9. 2011
    ..However, further studies are highly encouraged to examine the CV benefit of PS enriched food...
  57. ncbi request reprint [Role of triglycerides in cardiovascular diseases]
    E Bruckert
    , , Paris
    Arch Mal Coeur Vaiss 85:29-35. 1992
    ..Despite these epidemiological data, the measurement of serum triglyceride levels remains important in patients with hyperlipidemia...
  58. ncbi request reprint Low HDL-cholesterol is common in European Type 2 diabetic patients receiving treatment for dyslipidaemia: data from a pan-European survey
    E Bruckert
    Groupe Hospitalier Pitie Salpetriere, Paris, France
    Diabet Med 24:388-91. 2007
    ..To measure the prevalence of low high-density lipoprotein (HDL)-cholesterol (men < 1.03 mmol/l; women < 1.29 mmol/l) in European Type 2 diabetic patients receiving treatment for dyslipidaemia...
  59. ncbi request reprint Dietary supplementation contributes to lifestyle improvement in hypercholesterolemic patients in real-life contexts
    E Bruckert
    Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Paris, France
    Curr Med Res Opin 30:1309-16. 2014
    ....
  60. ncbi request reprint Effects of octreotide on lipid metabolism in acromegaly
    R Cohen
    Department of Internal Medicine and Endocrinology, , Paris, France
    Horm Metab Res 24:397-400. 1992
    ..In conclusion, the administration of octreotide over a three month period to acromegalic patients is associated with a decrease in TG levels...
  61. ncbi request reprint [The growth hormone/insulin-like growth factor axis. What is its role in the atherosclerotic process?]
    T B Twickler
    INSERM Unité 551, Hopital Pitie Salpetriere, Paris
    Presse Med 32:1238-43. 2003
    ..GROWTH HORMONE AND ATHEROSCLEROSIS: Adult-onset growth hormone (GH) deficiency is associated with an increase in cardiovascular morbidity and mortality...
  62. ncbi request reprint APOE: a potential marker of disease progression in ALS
    L Lacomblez
    Fédération de Neurologie Mazarin, Service de Pharmacologie, AP HP, Hopital de la Salpetriere, Paris, France
    Neurology 58:1112-4. 2002
    ..In contrast, APOE plasma levels were correlated with both rate of deterioration and survival time and appeared to be an important risk factor for decreased survival time with a relative risk of 0.647 (95% CI: 0.465 to 0.901; p = 0.01)...
  63. pmc Patients' and physicians' perceptions and experience of hypercholesterolaemia: a qualitative study
    Isabelle Durack-Bown
    Unit for the Prevention of Cardiovascular Disease, Hopital de la Pitie Salpetriere, Paris, France
    Br J Gen Pract 53:851-7. 2003
    ..A better understanding of patients' and physicians' perceptions and experience of hypercholesterolaemia will help to improve cardiovascular disease prevention and aid the development of appropriate educational strategies...
  64. ncbi request reprint [Factors associated with the opinion of hypercholesterolemic patients on the duration of their treatment. Results of the FRACTION study]
    Silla M Consoli
    Service de psychologie clinique et psychiatrie de liaison, Hopital Europeen Georges Pompidou, 20, rue Leblanc 75908 Paris
    Presse Med 31:1302-8. 2002
    ..The patients' opinion concerning the severity and evolution of their health problem, as well as the use and duration of their treatment, are, in this context, essential...
  65. ncbi request reprint Action of ciprofibrate in type IIb hyperlipoproteinemia: modulation of the atherogenic lipoprotein phenotype and stimulation of high-density lipoprotein-mediated cellular cholesterol efflux
    Maryse Guerin
    Institut National de la Santé et de la Recherche Médicale Unité 551, Dyslipoproteinemia and Atherosclerosis, Hopital de la Pitie, 75651 Paris, France
    J Clin Endocrinol Metab 88:3738-46. 2003
    ....
  66. ncbi request reprint Serum plasma pregnancy-associated protein A: a potential marker of echogenic carotid atherosclerotic plaques in asymptomatic hyperlipidemic subjects at high cardiovascular risk
    Jean Louis Beaudeux
    Department of Clinical Biochemistry, the National Institute for Health, Paris, France
    Arterioscler Thromb Vasc Biol 23:e7-10. 2003
    ..We evaluated serum PAPP-A levels as a marker of the premature development of atherosclerosis in hyperlipidemic subjects at elevated cardiovascular risk...
  67. ncbi request reprint Serum matrix metalloproteinase-3 and tissue inhibitor of metalloproteinases-1 as potential markers of carotid atherosclerosis in infraclinical hyperlipidemia
    Jean Louis Beaudeux
    Department of Clinical Biochemistry, Groupe Hospitalier Pitie Salpetriere, 47 83 boulevard de l Hopital, Paris Cedex 13 F75651, France
    Atherosclerosis 169:139-46. 2003
    ..Such elevations might reflect enhanced vascular matrix remodeling, a key feature of the progression of atherosclerotic disease...
  68. ncbi request reprint Short-term efficacy and safety of extended-release fluvastatin in a large cohort of elderly patients
    Eric Bruckert
    Service d Endocrinologie Métabolisme, Pavillon Benjamin Delessert, Hopital de la Pitie, Paris, France
    Am J Geriatr Cardiol 12:225-31. 2003
    ..These findings are consistent with data obtained previously in younger recipients of fluvastatin XL 80 mg, and reinforce the safety of fluvastatin in a population at high risk of drug-drug interactions...
  69. ncbi request reprint [Ten-year morbidity and mortality in a cohort of dyslipidemic patients seen at a hospital endocrinology department]
    Valérie Carreau
    Service d Endocrinologie Métabolisme, AP HP, Groupe Hospitalier Pitie Salpetriere, F 75651 Paris Cedex 13, France
    Presse Med 37:385-94. 2008
    ....
  70. doi request reprint Elevated gamma-glutamyltransferase activity and perturbed thiol profile are associated with features of metabolic syndrome
    Philippe Giral
    Unités de Prévention Cardiovasculaire, Groupe Hospitalier Pitié Salpétrière Université Pierre et Marie Curie, 75651 Paris Cedex 13, France
    Arterioscler Thromb Vasc Biol 28:587-93. 2008
    ..We compared the circulating thiol profile in a cohort of patients displaying atherogenic dyslipidemia with and without MS...
  71. ncbi request reprint Efficacy and safety of ezetimibe coadministered with atorvastatin or simvastatin in patients with homozygous familial hypercholesterolemia
    Claude Gagne
    CHUL du CHUQ, Ste Foy, Quebec, Canada
    Circulation 105:2469-75. 2002
    ..5% (P=0.0001) versus statin-80. Similar significant reductions in LDL-C concentrations were observed for patients with genotype-confirmed HoFH (n=35). Ezetimibe was safe and well tolerated...
  72. ncbi request reprint Matrix metalloproteinases, inflammation and atherosclerosis: therapeutic perspectives
    Jean Louis Beaudeux
    Department of Clinical Biochemistry, Groupe Hospitalier Pitie Salpetriere, AP HP, Paris, France
    Clin Chem Lab Med 42:121-31. 2004
    ..This review describes the members of the MMP and TIMP families and discusses the structure, function and regulation of MMP activity; finally, pharmacological approaches to MMP inhibition are highlighted...
  73. ncbi request reprint One third of the variability in HDL-cholesterol level in a large dyslipidaemic population is predicted by age, sex and triglyceridaemia: The Paris La Pitié Study
    Boris Hansel
    Service d Endocrinologie Métabolisme AP HP, Hopital de la Pitie, Paris, France
    Curr Med Res Opin 22:1149-60. 2006
    ....
  74. ncbi request reprint Hypothyroidism and cardiovascular disease: role of new risk factors and coagulation parameters
    Christel Jublanc
    Service d Endocrinologie Métabolisme, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Paris, France
    Semin Vasc Med 4:145-51. 2004
    ....
  75. ncbi request reprint Elevated serum levels of proinflammatory cytokines and biomarkers of matrix remodeling in never-treated patients with familial hypercholesterolemia
    Mariame El Messal
    Faculte des Sciences Ain Chock, Universite Hassan II Ain Chock, Casablanca, Morocco
    Clin Chim Acta 366:185-9. 2006
    ..Although FH is monogenic, wide variation occurs in the onset and severity of atherosclerosis in these patients...
  76. ncbi request reprint Intake of added oils and fats among middle-aged French adults: relationships with educational level and region of residence
    Sebastien Czernichow
    Department of Nutrition, Hotel Dieu Hospital, University Pierre et Marie Curie, Paris, France
    J Am Diet Assoc 105:1889-94. 2005
    ..To describe the relative contribution of 10 created food groups to total fat intake in middle-aged subjects. The relationship of added oil and fat intake with region of residence and educational level was also assessed...
  77. ncbi request reprint Effect of low-fat, fermented milk enriched with plant sterols on serum lipid profile and oxidative stress in moderate hypercholesterolemia
    Boris Hansel
    Service d Endocrinologie Métabolisme, AP HP, Hopital de la Pitie, Paris, France
    Am J Clin Nutr 86:790-6. 2007
    ..Plant sterol (PS)-enriched foods have been shown to reduce plasma LDL-cholesterol concentrations. In most studies, however, PSs were incorporated into food products of high fat content...
  78. ncbi request reprint Use of an indirect effect model to describe the LDL cholesterol-lowering effect by statins in hypercholesterolaemic patients
    Demiana William Faltaos
    Pharmacology Department, Pitie Salpetriere University Hospital, Assistance Publique Hopitaux de Paris, Paris 6 University, Paris, France
    Fundam Clin Pharmacol 20:321-30. 2006
    ..The pharmacodynamic parameters for the three statins were accurately estimated. The PK/PD model developed successfully predicted the time course of the LDL-lowering effect of statins...
  79. ncbi request reprint Blood lipids in brain infarction subtypes
    Pierre Amarenco
    Department of Neurology and Stroke Centre, Bichat Hospital, Denis Diderot University, INSERM U 360, Paris, France
    Cerebrovasc Dis 22:101-8. 2006
    ..Little is known about the relationship between hypercholesterolaemia and specific aetiological subtypes of brain infarction (BI)...
  80. ncbi request reprint Adipose tissue IL-6 content correlates with resistance to insulin activation of glucose uptake both in vivo and in vitro
    Jean Philippe Bastard
    Service de Biochimie et Hormonologie, Hôpital Tenon Rothschild, Assistance Publique Hopitaux de Paris AP HP, 75020 Paris, France
    J Clin Endocrinol Metab 87:2084-9. 2002
    ..In conclusion, increased IL-6 production by sc adipose cells might participate to the insulin-resistant state observed in human obesity...
  81. ncbi request reprint LDL particle subclasses in hypercholesterolemia. Molecular determinants of reduced lipid hydroperoxide stability
    Laurent Chancharme
    Institut National de la Santé et de la Recherche Médicale INSERM U551, Pavillon Benjamin Delessert, Hopital de la Pitie, 83 Blvd l Hôpital, 75651 Paris Cedex 13, France
    J Lipid Res 43:453-62. 2002
    ..Elevated concentrations of large, CE-rich, light, and intermediate LDL subclasses (LDL1+2, LDL3) in hypercholesterolemia may therefore act as an abundant proatherogenic source of highly unstable LOOH in the arterial wall...
  82. ncbi request reprint Lipoprotein lipase activity and common gene variants in severely hypertriglyceridemic patients with and without diabetes
    Rita Chadarevian
    Service d Endocrinologie Métabolisme, Unités de prévention des maladies cardiovasculaires et Institut Fédératif de recherche Coeur Muscle et Vaisseaux, Assistance Publique Hopitaux de Paris, Paris, France
    Horm Res 60:61-7. 2003
    ..In severe type IV hypertriglyceridemia (triglyceride levels >10 g/l), it is yet unknown whether lipoprotein lipase (LPL) differs according to the presence or not of diabetes...
  83. doi request reprint Acute pancreatitis in a cohort of 129 patients referred for severe hypertriglyceridemia
    Celia Lloret Linares
    Nutrition, Pitie Salpetriere Hospital, AP HP, Paris, France
    Pancreas 37:13-2. 2008
    ....
  84. doi request reprint Rosiglitazone for nonalcoholic steatohepatitis: one-year results of the randomized placebo-controlled Fatty Liver Improvement with Rosiglitazone Therapy (FLIRT) Trial
    Vlad Ratziu
    Universite Pierre et Marie Curie Paris VI, Assistance Publique Hopitaux de Paris, Service d Hepatogastroenterologie, Paris, France
    Gastroenterology 135:100-10. 2008
    ..Nonalcoholic steatohepatitis (NASH) is a liver disease that complicates insulin-resistant states. This trial tested the efficacy and safety of rosiglitazone, an insulin-sensitizing agent, in patients with NASH...
  85. doi request reprint Is serum cystatin-C a reliable marker for metabolic syndrome?
    Aude Servais
    Department of Nephrology, Pitie Salpetriere Hospital, Paris, France
    Am J Med 121:426-32. 2008
    ..We measured cystatin values in dyslipidemic patients and looked for correlations between renal function, cystatin, and metabolic syndrome...
  86. doi request reprint [Abdominal obesity: a health threat]
    Eric Bruckert
    Service d Endocrinologie Métabolisme, Hopital Pitie Salpetriere, F 75013 Paris, France
    Presse Med 37:1407-14. 2008
    ..New pharmacological strategies might help manage both abdominal obesity and its metabolic consequences...
  87. ncbi request reprint Metabolic syndrome is associated with elevated oxidative stress and dysfunctional dense high-density lipoprotein particles displaying impaired antioxidative activity
    Boris Hansel
    Dyslipoproteinemia and Atherosclerosis Research Unit, National Institute for Health and Medical Research, Institut National de la Sante et de la Recherche Medicale, Hopital de la Pitie, 75013 Paris, France
    J Clin Endocrinol Metab 89:4963-71. 2004
    ..Induction of selective increase in the circulating concentrations of dense HDL subfractions may represent an innovative therapeutic approach for the attenuation of high cardiovascular risk in MetS...
  88. ncbi request reprint A comprehensive description of muscle symptoms associated with lipid-lowering drugs
    Sylvia Franc
    Department of Endocrinology, Hopital de la Pitie Salpetriere, Assistance Publique Hopitaux de Paris, 83 bd de l hopital, 75013 Paris, France
    Cardiovasc Drugs Ther 17:459-65. 2003
    ..A spectrum of disease from myalgia to rhabdomyolysis exists as classic side-effect of lipid-lowering treatment (LLT). While myopathy has generated considerable interest, mild musculo-skeletal symptoms are poorly assessed...
  89. ncbi request reprint Cardiovascular risk and rheumatoid arthritis: clinical practice guidelines based on published evidence and expert opinion
    Thao Pham
    Service de Rhumatologie, CHU de la Conception, Marseille, France
    Joint Bone Spine 73:379-87. 2006
    ..To develop clinical practice guidelines for the evaluation and management of cardiovascular risk in patients with rheumatoid arthritis (RA), using the evidence-based approach and expert opinion...
  90. ncbi request reprint A new approach to decrease serum cholesterol levels
    Eric Bruckert
    Cardiovasc Drugs Ther 20:157-8. 2006
  91. ncbi request reprint Prevention campaigns for cardiovascular disease
    Eric Bruckert
    Lancet 362:1767-8. 2003
  92. ncbi request reprint Magnitude of HDL cholesterol variation after high-dose atorvastatin is genetically determined at the LDL receptor locus in patients with homozygous familial hypercholesterolemia
    Andrei C Sposito
    Dyslipoproteinemia and Atherosclerosis Research Unit U 551, National Institute for Health and Medical Research, Paris, France
    Arterioscler Thromb Vasc Biol 23:2078-82. 2003
    ..However, some concerns have been made about the effect of atorvastatin on HDL cholesterol levels in these patients...
  93. ncbi request reprint Adiponutrin: A new gene regulated by energy balance in human adipose tissue
    Yong Ming Liu
    Equipe d Accueil 3502 and Institut National de la Santé et de la Recherche Médicale INSERM Avenir and Department de Nutrition, Paris VI University, Paris, France
    J Clin Endocrinol Metab 89:2684-9. 2004
    ..These results indicate that adiponutrin gene expression in humans is highly regulated by changes in energy balance...
  94. ncbi request reprint Metabolic syndrome features small, apolipoprotein A-I-poor, triglyceride-rich HDL3 particles with defective anti-apoptotic activity
    Juliana A de Souza
    Universite Pierre et Marie Curie Paris 6, Paris F 75013, France
    Atherosclerosis 197:84-94. 2008
    ....
  95. ncbi request reprint Cellular SR-BI and ABCA1-mediated cholesterol efflux are gender-specific in healthy subjects
    Giovanna Catalano
    Institut National de la Sante et de la Recherche Medicale, UMR_S551, Dyslipoproteinemia and Atherosclerosis, Paris, France
    J Lipid Res 49:635-43. 2008
    ..72, P < 0.0001), whereas this relationship was not observed in men. In conclusion, HDL-C level may not represent the absolute indicator of the efficiency of the initial step of the reverse cholesterol transport...
  96. doi request reprint Patients with the metabolic syndrome and a disturbed cortisol balance display more microalbuminuria
    Sarah F Janssen
    Department of Cardiology, University Medical Centre UMC Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Diab Vasc Dis Res 5:54-8. 2008
    ....
  97. ncbi request reprint Renal disease in cardiovascular disorders: an underrecognized problem
    Alain Baumelou
    Department of Nephrology, Hopital Pitie Salpetriere, Paris, France
    Am J Nephrol 25:95-105. 2005
    ..Pilot programs for screening high-risk populations have shown efficacy in detecting renal disease...