Lecoutre S, Petrus P, Ryden M, Breton C. Transgenerational Epigenetic Mechanisms in Adipose Tissue Development. Trends Endocrinol Metab. 2018;: pubmed publisher
..Understanding the complex interactions between maternal diet and epigenetic regulation of the AT in offspring may be valuable in improving preventive strategies against the obesity pandemic. ..
Breton C. Role of maternal nutrition in programming adiposity in the offspring: potential implications of glucocorticoids. Horm Mol Biol Clin Investig. 2013;14:33-47 pubmed publisher
..Following maternal malnutrition, the epigenetic mechanisms might also be responsible for the adipose tissue programming. ..
Breton C. The hypothalamus-adipose axis is a key target of developmental programming by maternal nutritional manipulation. J Endocrinol. 2013;216:R19-31 pubmed publisher
..Dietary supplementation may provide a therapeutic option using a specific regimen for reversing adverse programming outcomes in humans. ..
Lecoutre S, Deracinois B, Laborie C, Eberle D, Guinez C, Panchenko P, et al
. Depot- and sex-specific effects of maternal obesity in offspring's adipose tissue. J Endocrinol. 2016;230:39-53 pubmed publisher
..Thus, maternal obesity and accelerated growth during lactation program offspring for higher adiposity via transcriptional alterations of visceral adipose tissue in a depot- and sex-specific manner. ..
Lecoutre S, Oger F, Pourpe C, Butruille L, Marousez L, Dickes Coopman A, et al
. Maternal obesity programs increased leptin gene expression in rat male offspring via epigenetic modifications in a depot-specific manner. Mol Metab. 2017;6:922-930 pubmed publisher
..Consistent with the DOHaD hypothesis, persistent epigenetic remodeling occurs at regulatory regions especially within intergenic sequences, linked to higher leptin gene expression in adult HF offspring in a depot-specific manner. ..
Lecoutre S, Pourpe C, Butruille L, Marousez L, Laborie C, Guinez C, et al
. Reduced PPAR?2 expression in adipose tissue of male rat offspring from obese dams is associated with epigenetic modifications. FASEB J. 2018;: pubmed publisher
..Laborie, C., Guinez, C., Lesage, J., Vieau, D., Eeckhoute, J., Gabory, A., Oger, F., Eberlé, D., Breton, C. Reduced PPAR?2 expression in adipose tissue of male rat offspring from obese dams is associated with epigenetic modifications. ..
Breton C, Lukaszewski M, Risold P, Enache M, Guillemot J, Rivière G, et al
. Maternal prenatal undernutrition alters the response of POMC neurons to energy status variation in adult male rat offspring. Am J Physiol Endocrinol Metab. 2009;296:E462-72 pubmed publisher
..Our data suggest that maternal undernutrition differently programs the long-term appetite-regulatory system of offspring, especially the response of POMC neurons to energy status and food intake rhythm. ..