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Genomes and GenesSpecies | Gregoire Le GalSummaryAffiliation: Brest University Hospital Country: France Publications
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Publications
Clinical decision rules in venous thromboembolismGregoire Le Gal
Department of Internal Medicine and Chest Diseases and EA3878, Brest University Hospital, Brest, France
Best Pract Res Clin Haematol 25:303-17. 2012..In this paper we critically review the use of CDRs in prevention, diagnosis and treatment of VTE and highlight those CDRs that are ready for the prime time of daily clinical use...- New anticoagulants in the treatment of VTEGregoire Le Gal
Universite Europeenne de Bretagne, centre d investigation clinique, Hopital de la Cavale Blanche, Boulevard Tanguy Prigent, Brest Cedex, France
Semin Respir Crit Care Med 33:191-8. 2012..They may facilitate outpatient management of VTE. They might also improve the risk-benefit balance of prolonged anticoagulation and therefore modify the optimal duration of anticoagulation in VTE patients... 
Diagnostic value of single complete compression ultrasonography in pregnant and postpartum women with suspected deep vein thrombosis: prospective studyGregoire Le Gal
INSERM CIC 05 02, Centre Hospitalier Universitaire de la Cavale Blanche, Brest, France
BMJ 344:e2635. 2012..To assess the safety of using single complete compression ultrasonography in pregnant and postpartum women to rule out deep vein thrombosis...
Diagnostic value of a negative single complete compression ultrasound of the lower limbs to exclude the diagnosis of deep venous thrombosis in pregnant or postpartum women: a retrospective hospital-based studyGregoire Le Gal
EA 3878 and Department of Internal Medicine and Chest Diseases, Brest University Hospital, Brest, France
Thromb Res 118:691-7. 2006....- A positive compression ultrasonography of the lower limb veins is highly predictive of pulmonary embolism on computed tomography in suspected patientsGregoire Le Gal
EA 3878, département de médecine interne et de pneumologie, CHU de la Cavale Blanche, 29609 Brest Cedex, France
Thromb Haemost 95:963-6. 2006..It allows ruling in the diagnosis of PE without further invasive and/or expensive testing in suspected patients... - [Clinical diagnosis of pulmonary embolism: a real challenge]G Le Gal
département de médecine interne et pneumologie, Centre Hospitalier Universitaire de la Cavale Blanche, EA 3878 Groupe d Etude de la Thrombose de Bretagne Occidentale, Boulevard Tanguy Prigent, 29609 Brest Cedex, France
Rev Med Interne 28:394-9. 2007..The diminution of the proportion of confirmed cases among suspected patients is a new challenge for physicians, and raises the question of what is a clinical suspicion of pulmonary embolism... - Prediction of pulmonary embolism in the emergency department: the revised Geneva scoreGregoire Le Gal
Brest University Hospital, Brest, France
Ann Intern Med 144:165-71. 2006..Diagnosis of pulmonary embolism requires clinical probability assessment. Implicit assessment is accurate but is not standardized, and current prediction rules have shortcomings... - Value of D-dimer testing for the exclusion of pulmonary embolism in patients with previous venous thromboembolismGregoire Le Gal
Department of Internal Medicine and Chest Diseases, Brest University Hospital, Brest, France
Arch Intern Med 166:176-80. 2006.... - Fibrinogen Aalpha-Thr312Ala and factor XIII-A Val34Leu polymorphisms in idiopathic venous thromboembolismGregoire Le Gal
EA 3878, Department of Internal Medicine and Chest Diseases, Brest University Hospital, Brest, France
Thromb Res 121:333-8. 2007..However, clinical studies have yielded conflicting results on their possible association with venous thromboembolism (VTE)... - Differential value of risk factors and clinical signs for diagnosing pulmonary embolism according to ageG Le Gal
Department of Internal Medicine and Chest Diseases EA 3878, Brest University Hospital, Brest, France
J Thromb Haemost 3:2457-64. 2005.... - Reproduction of chest pain by palpation: diagnostic accuracy in suspected pulmonary embolismGregoire Le Gal
Equipe d accueil 3878 GETBO, Brest University Hospital, 29609 Brest, France
BMJ 330:452-3. 2005 - [Clinical probability of PE: should we use a clinical prediction rule?]G Le Gal
EA 3878 Groupe d Etude de la Thrombose de Bretagne Occidentale, département de médecine interne et de pneumologie, CHU de la Cavale Blanche, Boulevard Tanguy Prigent, 29609 Brest Cedex, France
Rev Pneumol Clin 64:269-75. 2008..They allow all physicians, whatever their expertise, to reliably determine the clinical pretest probability of PE, and thus safely manage their patients using diagnostic and therapeutic algorithms... - Incidence of venous thromboembolism in first-degree relatives of patients with venous thromboembolism who have factor V LeidenFrancis Couturaud
GETBO, EA 3878, Department of Internal Medicine and Chest Diseases, University Hospital Centre La Cavale Blanche, 29609 Brest, Cedex, France
Thromb Haemost 96:744-9. 2006..FVL is associated with a two- to threefold increase in VTE in first-degree relatives of patients with VTE. No subgroup of relatives was identified who require more than routine prophylaxis because of a particularly high risk of VTE... - Association of common genetic variations and idiopathic venous thromboembolism. Results from EDITh, a hospital-based case-control studyAurelien Delluc
Université Européeenne de Bretagne, Universite de Brest, Brest, France
Thromb Haemost 103:1161-9. 2010..In this hospital-based case-control study, two polymorphisms located on the factor XI gene were significantly associated with VTE. Other newly investigated polymorphisms with potentially false negatives may warrant further analyses... - High frequency of factor V Leiden in surgical patients with symptomatic venous thromboembolism despite prophylaxisMohamed Baba-Ahmed
Department of Internal Medicine and Chest Diseases, Brest University Hospital, Brest, France
Thromb Haemost 97:171-5. 2007..4; 95% CI, 2.4 to 29). This study shows a close association between the presence of factorV Leiden mutation in symptomatic VTE occurring after surgery despite prophylaxis... - Noninvasive diagnosis of pulmonary embolismPierre Yves Salaun
Universite Europeenne de Bretagne, Brest, France
Chest 139:1294-8. 2011..Diagnosis was based on clinical probability assessment, plasma D-dimer testing, then sequential testing to include lower limb venous compression ultrasonography, ventilation perfusion lung scan, and chest multidetector CT (MDCT) imaging... - Assessment of carotid artery stenosis before coronary artery bypass surgery. Is it always necessary?Jean Christophe Cornily
Department of Cardiology, La Cavale Blanche Hospital, Brest University Hospital, Boulevard T Prigent, 29609 Brest Cedex, France
Arch Cardiovasc Dis 104:77-83. 2011..Although selective and non-selective methods of preoperative carotid screening have been advocated, it remains unclear if this screening is clinically relevant... - Cardiac multislice spiral computed tomography as an alternative to coronary angiography in the preoperative assessment of coronary artery disease before aortic valve surgery: a management outcome studyJean Christophe Cornily
Department of Cardiology, La Cavale Blanche Hospital, Brest University Hospital, Brest Cedex, France
Arch Cardiovasc Dis 103:170-5. 2010..Preliminary studies suggest that multislice spiral computed tomography coronary angiography (MSCT-CA) can be used to rule out coronary artery disease (CAD)... - Interrelation of hyperhomocysteinemia and inherited risk factors for venous thromboembolism. Results from the E.D.I.TH. study: a hospital-based case-control studyEmmanuel Oger
G E T B O EA 3878 Groupe d Etude de la Thrombose de Bretagne Occidentale, Department of Internal Medicine and Chest Diseases, Brest University Hospital, 29609 Brest Cedex, France
Thromb Res 120:207-14. 2007..The hypothesis of an interaction between those risks has been raised and conflicting results were reported... - Management of suspected pulmonary embolism patients with low clinical and low V/Q probabilityPierre Yves Salaun
département de médecine interne et de pneumologie, Centre Hospitalier Universitaire de la Cavale Blanche, 29609 Brest Cedex, France
Thromb Res 122:450-4. 2008.... - Diagnostic accuracy of single-photon emission tomography ventilation/perfusion lung scan in the diagnosis of pulmonary embolismAlexandra Le Duc-Pennec
Universite Europeenne de Bretagne, CHU de la Cavale Blanche, Brest, France
Chest 141:381-7. 2012..This study assessed the diagnostic performance of V/Q SPECT scan in a cohort of consecutive patients with suspected PE... - Site of venous thromboembolism and prothrombotic mutations according to body mass index. Results from the EDITH studyAurelien Delluc
Université Européenne de Bretagne EA 3878, IFR 148, Universite de Brest, 29609 Brest, France
Br J Haematol 154:486-91. 2011..This study showed that BMI may play a role in determining the site of VTE and may interact with F2 G20210A but not with F5 G1691A for the risk of VTE... - Cardiac tamponade in medical patients: a 10-year follow-up surveyJean Christophe Cornily
Department of Cardiology, Brest University Hospital, Brest, France
Cardiology 111:197-201. 2008..Cardiac tamponade represents a life-threatening condition that may complicate almost any cause of pericarditis. We conducted a 10-year prospective survey on patients with cardiac tamponade requiring an emergency drainage... - Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin: the randomized, double-blind OCLA (Omeprazole CLopidogrel Aspirin) studyMartine Gilard
Department of Cardiology, Brest University Hospital, Brest, France
J Am Coll Cardiol 51:256-60. 2008..This trial sought to assess the influence of omeprazole on clopidogrel efficacy... - Accuracy of 16-detector multislice spiral computed tomography in the initial evaluation of dilated cardiomyopathyJean Christophe Cornily
Department of Cardiology, Brest University Hospital, France
Eur J Radiol 61:84-90. 2007..It can also give information about left ventricular function and venous network anatomy. We here sought to validate a MSCT-based strategy in the initial evaluation of patients with dilated cardiomyopathy (DCM)... - Midterm prognosis of patients with suspected coronary artery disease and normal multislice computed tomographic findings: a prospective management outcome studyMartine Gilard
Department of Cardiology, Brest University Hospital, CHU de la Cavale Blanche, Boulevard Tanguy Prigent, 29609 Brest Cedex, France
Arch Intern Med 167:1686-9. 2007..The aim of our study is to prospectively assess the safety of ruling out CAD based solely on a normal MSCT-CAG result... - Medium-term survival of diffuse coronary artery disease patients following coronary artery reconstruction with the internal thoracic arteryAhmed Aziz Khalifa
Department of Cardiovascular and Thoracic Surgery, Brest University Hospital, Brest, France
Cardiology 120:192-9. 2011..The aim of the present study was to evaluate the medium-term results of coronary artery reconstruction... - Is APC resistance a risk factor for venous thromboembolism in patients over 70 years?Emmanuel Oger
Groupe d Etude de la Thrombose de Bretagne Occidentale, Department of Internal Medicine and Chest Diseases, Hopital de la Cavale Blanche, F 29609 Brest Cedex, France
Thromb Haemost 88:587-91. 2002..8, 95% CI, 0.4 to 1.7). Age appeared as an effect-measure modifier with a significant interaction (p = 0.005). Our data suggest that APC resistance is not a risk factor for VTE in elderly... - Differential associations between lipid-lowering drugs, statins and fibrates, and venous thromboembolism: role of drug induced homocysteinemia?Karine Lacut
Brest University, GETBO EA 3878, EPI PHARM, Brest, F 29609, France
Thromb Res 122:314-9. 2008..This report aims to test the hypothesis that part of these contrasting associations is related to total homocysteine level (tHcy)... - Venous thromboembolism in patients with pancreatic cancer: implications of circulating tissue factorAurelien Delluc
département de médecine interne et pneumologie, Faculte de Medecine et des Sciences de la Sante, Universite de Brest, CHU de Brest, Brest, France
Blood Coagul Fibrinolysis 22:295-300. 2011..01 pmol/l (range 0.05-43.92), P = 0.02]. Higher levels of circulating TFa during the course of pancreatic cancer may explain the higher incidence of VTE associated with this type of cancer... - Lipid lowering drugs and the risk of recurrent venous thromboembolismAurelien Delluc
Universite de Bretagne Occidentale, EA 3878, Brest, F 29609 France
Thromb Res 130:859-63. 2012..However, no studies have evaluated whether lipid-lowering drugs (LLD) use was associated with the risk of VTE recurrence... - Contemporary approach to the diagnosis of non-massive pulmonary embolismGregoire Le Gal
EA 3878 GETBO, Department of Internal Medicine and Chest Diseases, Brest University Hospital, France
Curr Opin Pulm Med 12:291-8. 2006..Minimally invasive diagnostic strategies for pulmonary embolism are in constant evolution, integrating new diagnostic tools along with the better use of clinical information... - Atrial flutter after non-congenital cardiac surgery: incidence, predictors and outcomeMarjaneh Fatemi
Department of Cardiology, Brest University Hospital, Brest, France
Int J Cardiol 153:196-201. 2011..Our study sought to investigate the incidence and predictors of AFL following non-congenital cardiac surgery, and the long-term outcome of this arrhythmia... - Impact of genetic factors (VKORC1, CYP2C9, CYP4F2 and EPHX1) on the anticoagulation response to fluindioneKarine Lacut
EA 3878, Universite de Bretagne Occidentale, F 29609 Brest, France
Br J Clin Pharmacol 73:428-36. 2012..The role of these variants in fluindione response is unknown. Our aim was to assess whether genetic factors contribute to the variability in the response to fluindione... - Diagnosis of pulmonary embolism: planar images generated from V/Q SPECT are not a reliable substitute for traditional planar V/Q scanPierre Yves Le Roux
European University of Brittany, France
Nucl Med Commun 33:695-700. 2012..The aim was to evaluate the accuracy of angular summed planar scans in comparison with true planar images... - Differential effects of oral and transdermal postmenopausal estrogen replacement therapies on C-reactive proteinKarine Lacut
Departement de Medecine Interne, Hopital de la Cavale Blanche, Brest, France
Thromb Haemost 90:124-31. 2003..The clinical relevance of these effects remains to be determined... - Family history as a risk factor for venous thromboembolismSoledad Noboa
Faculté de Médecine et des Sciences de la Santé de Brest, Université de Bretagne, Occidentale UBO, Brest, France
Thromb Res 122:624-9. 2008..There are very few data assessing a family history of venous thromboembolism (VTE) as a risk factor for VTE. This question is nonetheless of interest as inherited risk factors are involved but at least partly unknown... - Gut dysfunction and endoscopic lesions after out-of-hospital cardiac arrestErwan L'Her
Reanimation et Urgences Medicales, CHU de la Cavale Blanche, 29609 Brest Cedex, France
Resuscitation 66:331-4. 2005..The objective of this study was to assess the frequency of gut dysfunction and endoscopic lesions following resuscitation after cardiac arrest, and to evaluate the potential value of gut endoscopy performance in these circumstances... - Antiplatelet drug use preceding the onset of intracerebral hemorrhage is associated with increased mortalityKarine Lacut
Department of Internal Medicine and Chest Diseases, G E T B O Groupe d Etude de la Thrombose de Bretagne Occidentale, Brest Cedex, France
Fundam Clin Pharmacol 21:327-33. 2007..Current antiplatelet drug use preceding the onset of ICH is associated with increased short-term ICH mortality, independently of age... - Biological determinants of bleeding in patients with heterozygous factor XI deficiencyPaul Guéguen
Centre Hospitalier Régional Universitaire de Brest, Haematology Laboratory, Brest, France
Br J Haematol 156:245-51. 2012..When considering BS as a continuous variable, only VWF:RCo remained significant (P=0·042), which accounted for 11% of the variability in BS... - Lipid parameters, lipid lowering drugs and the risk of venous thromboembolismAurelien Delluc
Brest University, GETBO EA 3878, Brest Cedex F 29609, France
Atherosclerosis 220:184-8. 2012..Besides their effects on atherogenesis, lipids and lipoproteins could contribute to the development of venous thromboembolism (VTE). This association has been investigated in a few studies with conflicting results... - [Do observational studies have a role in assessing treatment?]Karine Lacut
EA 3878 Groupe d Etude de la Thrombose de Bretagne Occidentale, département de médecine interne et de pneumologie, CHU de la Cavale Blanche, Brest
Presse Med 36:536-40. 2007.... - Benfluorex and unexplained valvular heart disease: a case-control studyIrène Frachon
Universite Europeenne de Bretagne, Brest, France
PLoS ONE 5:e10128. 2010..Recent case reports suggest that benfluorex, a fenfluramine derivative used in the management of overweight diabetic patients and dyslipidemia, is associated with cardiac valve regurgitation... - Multi-slice computer tomography of left ventricular function with automated analysis software in comparison with conventional ventriculographyMartine Gilard
Department of Cardiology, EA 3878, Brest University Hospital, Brest, France
Eur J Radiol 59:270-5. 2006..To evaluate the accuracy of left ventricular volumetric and functional parameters from multi-slice computed tomography using automated analysis software, and to correlate results with those of invasive left ventriculography... - Estrogen receptor alpha polymorphism and venous thromboembolism in male and female: data from the EDITH studyEmmanuel Oger
EPI PHARM GETBO and GETBO EA 3878 Groupe d Etude de la Thrombose de Bretagne Occidentale, France
Thromb Res 119:433-9. 2007..454-397 T>C and venous thromboembolism (VTE) has been reported in postmenopausal women. Comprehensive data are lacking. We herein evaluated the risk for VTE related to c.454-397 T>C ER alpha gene polymorphism in both men and women... - Primary prevention of venous thromboembolism in elderly medical patientsKarine Lacut
GETBO EA 3878, CHU de Brest, Department of Internal Medicine and Chest Diseases, Hôpital Cavale Blanche, Brest, France
Clin Interv Aging 3:399-411. 2008.... - The use of epicardial electrogram as a simple guide to select the optimal site of left ventricular pacing in cardiac resynchronization therapyMarjaneh Fatemi
Department of Cardiology, Brest University Hospital, 29609, Brest Cedex, France
Cardiol Res Pract 2011:956062. 2011..Responders had a significantly longer ED and greater ratio of ED/QRS duration than nonresponders. An ED/QRS duration ≥0.38 predicted a response to CRT with 89% specificity and 53% sensitivity... 
Impact of a nurses' protocol-directed weaning procedure on outcomes in patients undergoing mechanical ventilation for longer than 48 hours: a prospective cohort study with a matched historical control groupJean Marie Tonnelier
Réanimation Médicale, Centre Hospitalier Universitaire de la Cavale Blanche, Brest, France
Crit Care 9:R83-9. 2005....- Accuracy of multislice computed tomography in the preoperative assessment of coronary disease in patients with aortic valve stenosisMartine Gilard
Department of Cardiology, Brest University Hospital, Brest, France
J Am Coll Cardiol 47:2020-4. 2006.... - Investigations for bone metastasis from an unknown primaryClaire Destombe
La Cavale Blanche Teaching Hospital, Brest, France
Joint Bone Spine 74:85-9. 2007..To evaluate the respective contributions of various investigations used to identify the primary tumor in a cohort of patients referred for diagnostic evaluation of one or more bone metastases... - Use of arterial patch to improve re-endothelialization in a sheep model of open carotid endarterectomy. An incentive to use internal thoracic artery as an on-lay patch following coronary endarterecomy?Eric Bezon
Department of Cardio Vascular and Thoracic Surgery, University Hospital La Cavale Blanche, Brest, France
Interact Cardiovasc Thorac Surg 8:543-7. 2009..001). Arterial patch closure of open-endarterectomized artery improved regenerated endothelium quality...