K Lacut

..8, 95% CI, 0.4 to 1.7). Age appeared as an effect-measure modifier with a significant interaction (p = 0.005). Our data suggest that APC resistance is not a risk factor for VTE in elderly...

..The role of these variants in fluindione response is unknown. Our aim was to assess whether genetic factors contribute to the variability in the response to fluindione...

..They highlight the need to assess or re-evaluate mechanical devices by rigorous clinical trials...

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..Current antiplatelet drug use preceding the onset of ICH is associated with increased short-term ICH mortality, independently of age...

..This finding does not support a role for transdermal estrogen in the prevention of ischaemic heart disease in postmenopausal women...

..The clinical relevance of these effects remains to be determined...

..The aim of this study was to evaluate the association between the VKORC1 1173C > T polymorphism and venous thromboembolism (VTE)...

..More studies are needed in order to further elucidate this adverse effect, and to determine the possible predisposing factors and the biological mechanisms involved...

..This report aims to test the hypothesis that part of these contrasting associations is related to total homocysteine level (tHcy)...

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..However, certain drugs may be associated with a reduced risk of VTE. Although several studies indicate that aspirin and statins may favourably influence the risk of VTE, it is still not possible to draw up any practical recommendations...

..To assess intermittent pneumatic compression (IPC) in the prevention of venous thromboembolism (VTE)...

..4; 95% CI, 2.4 to 29). This study shows a close association between the presence of factorV Leiden mutation in symptomatic VTE occurring after surgery despite prophylaxis...

..Moderate hyperhomocysteinemia and B vitamins deficiency are thought to be risk factors for venous thromboembolism (VTE). The causality and independence of those associations are still questioned...

..29-0.70). In this hospital-based case-control study, a preventive role for angiotensin II receptor blockers as regards VTE risk was suggested. More studies are needed in order to further elucidate the biological mechanisms involved...

..In this hospital-based case-control study, two polymorphisms located on the factor XI gene were significantly associated with VTE. Other newly investigated polymorphisms with potentially false negatives may warrant further analyses...

..In addition, the development of anticoagulation clinics and new oral anticoagulants should help to reduce anticoagulant related bleeding for an equivalent, or an increased, benefit...

..The studies targeting the management of suspected post-operative pulmonary embolism are rare and warrant further encouragement...

..Whether addition of progestin plays a significant role is undetermined so far...

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..This study aimed to test the hypothesis that an association also exists in the elderly...

..5 to 32.6%) and 6.0 per 1,000 person-days (95% confidence interval, 0.0 to 12.7) among patients over 80 years. A high prevalence of asymptomatic deep vein thrombosis on admission was suggested particularly among elderly medical patients...

..This trial sought to assess the influence of omeprazole on clopidogrel efficacy...

..Oral estrogen replacement therapy (ERT) has been reported to induce APC resistance. Little is known about the effect of transdermal estrogen...

..However, clinical studies have yielded conflicting results on their possible association with venous thromboembolism (VTE)...

..This possible protective effect of statins warrants further investigations...

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..This secondary analysis, based on a large randomized trial, aimed to estimate the effect of the route of administration of 17beta-oestradiol in combined hormone replacement therapy with progesterone on IGF-1 and IGFBP-3 levels...

..454-397 T>C and venous thromboembolism (VTE) has been reported in postmenopausal women. Comprehensive data are lacking. We herein evaluated the risk for VTE related to c.454-397 T>C ER alpha gene polymorphism in both men and women...

..The hypothesis of an interaction between those risks has been raised and conflicting results were reported...

..FVL is associated with a two- to threefold increase in VTE in first-degree relatives of patients with VTE. No subgroup of relatives was identified who require more than routine prophylaxis because of a particularly high risk of VTE...

..Venous thrombosis is a multifactorial disease and analysis of the interactions between acquired and inherited risk factors is an extremely interesting field of investigation...

..CONCLUSION: No improvement in the diagnostic work-up in the event of a suspected pulmonary embolism was observed following this multifaceted intervention...

..0001). CONCLUSIONS: The results from this study suggest that transthoracic sonography of the lung does not fulfill satisfactory performance criteria in view of a clinical suspicion of pulmonary embolism...

..There are very few data assessing a family history of venous thromboembolism (VTE) as a risk factor for VTE. This question is nonetheless of interest as inherited risk factors are involved but at least partly unknown...

..Trials based on clinical end points should be conducted to evaluate the clinical relevance of these observations...