K Lacut

Summary

Affiliation: Brest University Hospital
Country: France

Publications

  1. ncbi request reprint Is APC resistance a risk factor for venous thromboembolism in patients over 70 years?
    Emmanuel Oger
    Groupe d Etude de la Thrombose de Bretagne Occidentale, Department of Internal Medicine and Chest Diseases, Hopital de la Cavale Blanche, F 29609 Brest Cedex, France
    Thromb Haemost 88:587-91. 2002
  2. pmc Impact of genetic factors (VKORC1, CYP2C9, CYP4F2 and EPHX1) on the anticoagulation response to fluindione
    Karine Lacut
    EA 3878, Universite de Bretagne Occidentale, F 29609 Brest, France
    Br J Clin Pharmacol 73:428-36. 2012
  3. ncbi request reprint [Mechanical prophylaxis of venous thromboembolism]
    Karine Lacut
    centre d investigation clinique, CHRU de Brest, Hopital de la Cavale Blanche, 29609 Brest Cedex
    Rev Prat 61:1232-6. 2011
  4. ncbi request reprint Antiplatelet drug use preceding the onset of intracerebral hemorrhage is associated with increased mortality
    Karine Lacut
    Department of Internal Medicine and Chest Diseases, G E T B O Groupe d Etude de la Thrombose de Bretagne Occidentale, Brest Cedex, France
    Fundam Clin Pharmacol 21:327-33. 2007
  5. ncbi request reprint Differential associations between lipid-lowering drugs, statins and fibrates, and venous thromboembolism: role of drug induced homocysteinemia?
    Karine Lacut
    Brest University, GETBO EA 3878, EPI PHARM, Brest, F 29609, France
    Thromb Res 122:314-9. 2008
  6. pmc Primary prevention of venous thromboembolism in elderly medical patients
    Karine Lacut
    GETBO EA 3878, CHU de Brest, Department of Internal Medicine and Chest Diseases, Hôpital Cavale Blanche, Brest, France
    Clin Interv Aging 3:399-411. 2008
  7. ncbi request reprint Effects of oral and transdermal 17 beta-estradiol combined with progesterone on homocysteine metabolism in postmenopausal women: a randomised placebo-controlled trial
    Karine Lacut
    Department of Internal Medicine and Chest Diseases, Brest University Hospital, Brest Cedex, France
    Atherosclerosis 174:173-80. 2004
  8. ncbi request reprint Differential effects of oral and transdermal postmenopausal estrogen replacement therapies on C-reactive protein
    Karine Lacut
    Departement de Medecine Interne, Hopital de la Cavale Blanche, Brest, France
    Thromb Haemost 90:124-31. 2003
  9. ncbi request reprint Association between antipsychotic drugs, antidepressant drugs and venous thromboembolism: results from the EDITH case-control study
    K Lacut
    EPI PHARM G E T B O, Equipe d accueil 3878, Department of Internal Medicine and Chest Diseases, Hopital de la Cavale Blanche, 29609 Brest Cedex, France
    Fundam Clin Pharmacol 21:643-50. 2007
  10. doi request reprint [Drugs and venous thromboembolism]
    K Lacut
    EA3878, département de médecine interne et pneumologie, CHU de Brest, Universite de Bretagne Occidentale, 29609 Brest Cedex, France
    Rev Pneumol Clin 64:290-7. 2008

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Is APC resistance a risk factor for venous thromboembolism in patients over 70 years?
    Emmanuel Oger
    Groupe d Etude de la Thrombose de Bretagne Occidentale, Department of Internal Medicine and Chest Diseases, Hopital de la Cavale Blanche, F 29609 Brest Cedex, France
    Thromb Haemost 88:587-91. 2002
    ..8, 95% CI, 0.4 to 1.7). Age appeared as an effect-measure modifier with a significant interaction (p = 0.005). Our data suggest that APC resistance is not a risk factor for VTE in elderly...
  2. pmc Impact of genetic factors (VKORC1, CYP2C9, CYP4F2 and EPHX1) on the anticoagulation response to fluindione
    Karine Lacut
    EA 3878, Universite de Bretagne Occidentale, F 29609 Brest, France
    Br J Clin Pharmacol 73:428-36. 2012
    ..The role of these variants in fluindione response is unknown. Our aim was to assess whether genetic factors contribute to the variability in the response to fluindione...
  3. ncbi request reprint [Mechanical prophylaxis of venous thromboembolism]
    Karine Lacut
    centre d investigation clinique, CHRU de Brest, Hopital de la Cavale Blanche, 29609 Brest Cedex
    Rev Prat 61:1232-6. 2011
    ..They highlight the need to assess or re-evaluate mechanical devices by rigorous clinical trials...
  4. ncbi request reprint Antiplatelet drug use preceding the onset of intracerebral hemorrhage is associated with increased mortality
    Karine Lacut
    Department of Internal Medicine and Chest Diseases, G E T B O Groupe d Etude de la Thrombose de Bretagne Occidentale, Brest Cedex, France
    Fundam Clin Pharmacol 21:327-33. 2007
    ..Current antiplatelet drug use preceding the onset of ICH is associated with increased short-term ICH mortality, independently of age...
  5. ncbi request reprint Differential associations between lipid-lowering drugs, statins and fibrates, and venous thromboembolism: role of drug induced homocysteinemia?
    Karine Lacut
    Brest University, GETBO EA 3878, EPI PHARM, Brest, F 29609, France
    Thromb Res 122:314-9. 2008
    ..This report aims to test the hypothesis that part of these contrasting associations is related to total homocysteine level (tHcy)...
  6. pmc Primary prevention of venous thromboembolism in elderly medical patients
    Karine Lacut
    GETBO EA 3878, CHU de Brest, Department of Internal Medicine and Chest Diseases, Hôpital Cavale Blanche, Brest, France
    Clin Interv Aging 3:399-411. 2008
    ....
  7. ncbi request reprint Effects of oral and transdermal 17 beta-estradiol combined with progesterone on homocysteine metabolism in postmenopausal women: a randomised placebo-controlled trial
    Karine Lacut
    Department of Internal Medicine and Chest Diseases, Brest University Hospital, Brest Cedex, France
    Atherosclerosis 174:173-80. 2004
    ..This finding does not support a role for transdermal estrogen in the prevention of ischaemic heart disease in postmenopausal women...
  8. ncbi request reprint Differential effects of oral and transdermal postmenopausal estrogen replacement therapies on C-reactive protein
    Karine Lacut
    Departement de Medecine Interne, Hopital de la Cavale Blanche, Brest, France
    Thromb Haemost 90:124-31. 2003
    ..The clinical relevance of these effects remains to be determined...
  9. ncbi request reprint Association between antipsychotic drugs, antidepressant drugs and venous thromboembolism: results from the EDITH case-control study
    K Lacut
    EPI PHARM G E T B O, Equipe d accueil 3878, Department of Internal Medicine and Chest Diseases, Hopital de la Cavale Blanche, 29609 Brest Cedex, France
    Fundam Clin Pharmacol 21:643-50. 2007
    ..More studies are needed in order to further elucidate this adverse effect, and to determine the possible predisposing factors and the biological mechanisms involved...
  10. doi request reprint [Drugs and venous thromboembolism]
    K Lacut
    EA3878, département de médecine interne et pneumologie, CHU de Brest, Universite de Bretagne Occidentale, 29609 Brest Cedex, France
    Rev Pneumol Clin 64:290-7. 2008
    ..However, certain drugs may be associated with a reduced risk of VTE. Although several studies indicate that aspirin and statins may favourably influence the risk of VTE, it is still not possible to draw up any practical recommendations...
  11. ncbi request reprint Vitamin K epoxide reductase genetic polymorphism is associated with venous thromboembolism: results from the EDITH Study
    K Lacut
    EA3878, Universite de Brest, Brest, France
    J Thromb Haemost 5:2020-4. 2007
    ..The aim of this study was to evaluate the association between the VKORC1 1173C > T polymorphism and venous thromboembolism (VTE)...
  12. ncbi request reprint [Do observational studies have a role in assessing treatment?]
    Karine Lacut
    EA 3878 Groupe d Etude de la Thrombose de Bretagne Occidentale, département de médecine interne et de pneumologie, CHU de la Cavale Blanche, Brest
    Presse Med 36:536-40. 2007
    ....
  13. ncbi request reprint Prevention of venous thrombosis in patients with acute intracerebral hemorrhage
    K Lacut
    Groupe d Etude de la Thrombose de Bretagne Occidentale, Equipe d accueil 3878, Cavale Blanche Hospital, Brest, France
    Neurology 65:865-9. 2005
    ..To assess intermittent pneumatic compression (IPC) in the prevention of venous thromboembolism (VTE)...
  14. ncbi request reprint High frequency of factor V Leiden in surgical patients with symptomatic venous thromboembolism despite prophylaxis
    Mohamed Baba-Ahmed
    Department of Internal Medicine and Chest Diseases, Brest University Hospital, Brest, France
    Thromb Haemost 97:171-5. 2007
    ..4; 95% CI, 2.4 to 29). This study shows a close association between the presence of factorV Leiden mutation in symptomatic VTE occurring after surgery despite prophylaxis...
  15. ncbi request reprint Hyperhomocysteinemia and low B vitamin levels are independently associated with venous thromboembolism: results from the EDITH study: a hospital-based case-control study
    E Oger
    GETBO EA 3878 Groupe d Etude de la Thrombose de Bretagne Occidentale, Department of Internal Medicine and Chest Diseases, Brest University Hospital, Brest, France
    J Thromb Haemost 4:793-9. 2006
    ..Moderate hyperhomocysteinemia and B vitamins deficiency are thought to be risk factors for venous thromboembolism (VTE). The causality and independence of those associations are still questioned...
  16. doi request reprint Antihypertensive drugs and risk of venous thromboembolism: results from the EDITH case-control study
    F Z Belattar
    Brest University, France
    Fundam Clin Pharmacol 24:255-9. 2010
    ..29-0.70). In this hospital-based case-control study, a preventive role for angiotensin II receptor blockers as regards VTE risk was suggested. More studies are needed in order to further elucidate the biological mechanisms involved...
  17. doi request reprint Association of common genetic variations and idiopathic venous thromboembolism. Results from EDITh, a hospital-based case-control study
    Aurelien Delluc
    Université Européeenne de Bretagne, Universite de Brest, Brest, France
    Thromb Haemost 103:1161-9. 2010
    ..In this hospital-based case-control study, two polymorphisms located on the factor XI gene were significantly associated with VTE. Other newly investigated polymorphisms with potentially false negatives may warrant further analyses...
  18. ncbi request reprint Assessment of the risk and prophylactic treatment of venous thromboembolism in the elderly
    F Couturaud
    Groupe d Etude de la Thrombose de Bretagne Occidentale GETBO, Brest, France
    Pathophysiol Haemost Thromb 33:362-5. 2003
    ..In addition, the development of anticoagulation clinics and new oral anticoagulants should help to reduce anticoagulant related bleeding for an equivalent, or an increased, benefit...
  19. ncbi request reprint [Hormone therapy and risk for venous thromboembolism in postmenopausal women]
    Karine Lacut
    Groupe d Etude de la Thrombose de Bretagne Occidentale, GETBO EA 3878, département de médecine interne et pneumologie, Hopital de la Cavale Blanche, 29609 Brest Cedex
    Rev Prat 55:389-92. 2005
    ..Whether addition of progestin plays a significant role is undetermined so far...
  20. ncbi request reprint [Diagnosis of postoperative venous thromboembolism]
    Maria Belen Moscoso
    G E T B O Groupe d Etude de la Thrombose de Bretagne Occidentale, département de médecine interne et pneumologie, Hopital de la Cavale Blanche, 29609 Brest
    Presse Med 32:852-9. 2003
    ..Although many general studies, assessing supplementary examination or diagnostic strategies are available, the proportion of patients concerned by a post-operative context varies...
  21. ncbi request reprint [Prolongation of anti vitamin K treatment for 18 months versus placebo after 6 months treatment of a first episode of ideopathic pulmonary embolism: a mutlicentre, randomised double blind trail. The PADIS-EP Trial]
    F Couturaud
    département de médecine interne et pneumologie, CHU de Brest, France
    Rev Mal Respir 25:885-93. 2008
    ....
  22. ncbi request reprint Fibrinogen Aalpha-Thr312Ala and factor XIII-A Val34Leu polymorphisms in idiopathic venous thromboembolism
    Gregoire Le Gal
    EA 3878, Department of Internal Medicine and Chest Diseases, Brest University Hospital, Brest, France
    Thromb Res 121:333-8. 2007
    ..However, clinical studies have yielded conflicting results on their possible association with venous thromboembolism (VTE)...
  23. doi request reprint Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin: the randomized, double-blind OCLA (Omeprazole CLopidogrel Aspirin) study
    Martine Gilard
    Department of Cardiology, Brest University Hospital, Brest, France
    J Am Coll Cardiol 51:256-60. 2008
    ..This trial sought to assess the influence of omeprazole on clopidogrel efficacy...
  24. ncbi request reprint Effects of the route of oestrogen administration on IGF-1 and IGFBP-3 in healthy postmenopausal women: results from a randomized placebo-controlled study
    Emmanuel Sonnet
    Service Endocrinologie, CHU de Brest, Hôpital Cavale Blanche, Brest, France
    Clin Endocrinol (Oxf) 66:626-31. 2007
    ..This secondary analysis, based on a large randomized trial, aimed to estimate the effect of the route of administration of 17beta-oestradiol in combined hormone replacement therapy with progesterone on IGF-1 and IGFBP-3 levels...
  25. ncbi request reprint Differential effects of oral and transdermal estrogen/progesterone regimens on sensitivity to activated protein C among postmenopausal women: a randomized trial
    Emmanuel Oger
    Departement de Medecine Interne, Hopital de la Cavale Blanche, Brest, France
    Arterioscler Thromb Vasc Biol 23:1671-6. 2003
    ..Oral estrogen replacement therapy (ERT) has been reported to induce APC resistance. Little is known about the effect of transdermal estrogen...
  26. ncbi request reprint Statins but not fibrates are associated with a reduced risk of venous thromboembolism: a hospital-based case-control study
    Karine Lacut
    Groupe d Etude de la Thrombose de Bretagne Occidentale GETBO, Department of Internal Medicine and Chest Diseases, Hopital de la Cavale Blanche, 29609 Brest Cedex, France
    Fundam Clin Pharmacol 18:477-82. 2004
    ..This possible protective effect of statins warrants further investigations...
  27. ncbi request reprint High plasma concentration of factor VIII coagulant is also a risk factor for venous thromboembolism in the elderly
    Emmanuel Oger
    Department of Internal Medicine and Chest Diseases, Hopital de la Cavale Blanche, F 29609 Brest Cedex, France
    Haematologica 88:465-9. 2003
    ..This study aimed to test the hypothesis that an association also exists in the elderly...
  28. ncbi request reprint High prevalence of asymptomatic deep vein thrombosis on admission in a medical unit among elderly patients
    Emmanuel Oger
    Groupe d Etude de la Thrombose de Bretagne Occidentale, Department of Internal Medecine and Chest Diseases, Hopital de la Cavale Blanche, F 29609 Brest Cedex, France
    Thromb Haemost 88:592-7. 2002
    ..5 to 32.6%) and 6.0 per 1,000 person-days (95% confidence interval, 0.0 to 12.7) among patients over 80 years. A high prevalence of asymptomatic deep vein thrombosis on admission was suggested particularly among elderly medical patients...
  29. ncbi request reprint Diagnostic value of a negative single complete compression ultrasound of the lower limbs to exclude the diagnosis of deep venous thrombosis in pregnant or postpartum women: a retrospective hospital-based study
    Gregoire Le Gal
    EA 3878 and Department of Internal Medicine and Chest Diseases, Brest University Hospital, Brest, France
    Thromb Res 118:691-7. 2006
    ....
  30. ncbi request reprint Estrogen receptor alpha polymorphism and venous thromboembolism in male and female: data from the EDITH study
    Emmanuel Oger
    EPI PHARM GETBO and GETBO EA 3878 Groupe d Etude de la Thrombose de Bretagne Occidentale, France
    Thromb Res 119:433-9. 2007
    ..454-397 T>C and venous thromboembolism (VTE) has been reported in postmenopausal women. Comprehensive data are lacking. We herein evaluated the risk for VTE related to c.454-397 T>C ER alpha gene polymorphism in both men and women...
  31. ncbi request reprint Interrelation of hyperhomocysteinemia and inherited risk factors for venous thromboembolism. Results from the E.D.I.TH. study: a hospital-based case-control study
    Emmanuel Oger
    G E T B O EA 3878 Groupe d Etude de la Thrombose de Bretagne Occidentale, Department of Internal Medicine and Chest Diseases, Brest University Hospital, 29609 Brest Cedex, France
    Thromb Res 120:207-14. 2007
    ..The hypothesis of an interaction between those risks has been raised and conflicting results were reported...
  32. ncbi request reprint Incidence of venous thromboembolism in first-degree relatives of patients with venous thromboembolism who have factor V Leiden
    Francis Couturaud
    GETBO, EA 3878, Department of Internal Medicine and Chest Diseases, University Hospital Centre La Cavale Blanche, 29609 Brest, Cedex, France
    Thromb Haemost 96:744-9. 2006
    ..FVL is associated with a two- to threefold increase in VTE in first-degree relatives of patients with VTE. No subgroup of relatives was identified who require more than routine prophylaxis because of a particularly high risk of VTE...
  33. doi request reprint Body mass index, a major confounder to insulin resistance association with unprovoked venous thromboembolism. Results from the EDITH case-control study
    A Delluc
    Dr Aurelien Delluc, EA3878 GETBO, IFR 148, Universite Europeenne de Bretagne, Department of Internal Medicine and Chest Diseases, Bd Tanguy Prigent, Brest, France 29609, Tel 33 298347336, Fax 33 298347944, E mail
    Thromb Haemost 110:593-7. 2013
    ..08; 95% CI 0.67-1.73). Our results highlight the role of body mass index in the association between cardiovascular risk factors and VTE. ..
  34. ncbi request reprint [Deep venous thrombosis: epidemiology, acquired risk factors]
    E Oger
    département de médecine interne et pneumologie, Hopital de la Cavale Blanche, 29609 Brest Cedex, France
    Ann Cardiol Angeiol (Paris) 51:124-8. 2002
    ..Venous thrombosis is a multifactorial disease and analysis of the interactions between acquired and inherited risk factors is an extremely interesting field of investigation...
  35. ncbi request reprint Transthoracic sonography of the lung and pleura in view of a suspected pulmonary embolism: a pilot study
    Katia Mohn
    Groupe d Etude de la Thrombose de Bretagne Occidentale, Department of Internal Medicine and Chest Diseases, Hopital de la Cavale Blanche, Brest, France
    J Ultrasound Med 22:673-8; quiz 680-1. 2003
    ..To evaluate the diagnostic performance of transthoracic sonography of the lung in view of an acute suspicion of pulmonary embolism...
  36. ncbi request reprint Management of suspected venous thromboembolism: the impact of a multifaceted intervention
    Pierre Yves Salaun
    Groupe d Etude de la Thrombose de Bretagne Occidentale GETBO, Hopital de la Cavale Blanche, F 29609 Brest Cedex, France
    Int J Qual Health Care 17:433-8. 2005
    ..To achieve a common strategy in the event of a suspected venous thromboembolism...
  37. doi request reprint Family history as a risk factor for venous thromboembolism
    Soledad Noboa
    Faculté de Médecine et des Sciences de la Santé de Brest, Université de Bretagne, Occidentale UBO, Brest, France
    Thromb Res 122:624-9. 2008
    ..There are very few data assessing a family history of venous thromboembolism (VTE) as a risk factor for VTE. This question is nonetheless of interest as inherited risk factors are involved but at least partly unknown...
  38. doi request reprint Antiplatelet drugs and risk of venous thromboembolism: results from the EDITH case-control study
    Karine Lacut
    Haematologica 93:1117-8. 2008
  39. ncbi request reprint Tinzaparin and enoxaparin given at prophylactic dose for eight days in medical elderly patients with impaired renal function: a comparative pharmacokinetic study
    Isabelle Mahe
    Service Médecine Interne A, Hopital Lariboisiere, 2, rue Ambroise Pare, Paris, France
    Thromb Haemost 97:581-6. 2007
    ..Trials based on clinical end points should be conducted to evaluate the clinical relevance of these observations...