Genomes and Genes
- Impact of HBV, HCV and GBV-C/HGV on hepatocellular carcinomas in Europe: results of a European concerted actionC Brechot
INSERM U370 and Liver Unit, CHU Necker, Paris, France
J Hepatol 29:173-83. 1998..To investigate the impact of hepatitis B (HBV) and C (HCV) infections on hepatocellular carcinoma (HCC) in Europe...
- Molecular bases for the development of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC)C Brechot
Liver Unit and INSERM U370, CNR Pasteur Necker Institute, Paris, France
Semin Cancer Biol 10:211-31. 2000..Finally the review by Dr Buendia highlights the emerging issue of liver-cancer genetics...
- Pathogenesis of hepatitis B virus-related hepatocellular carcinoma: old and new paradigmsChristian Brechot
Liver Unit and INSERM U370, Rene Descartes University, Pasteur Necker Institute, Paris, France
Gastroenterology 127:S56-61. 2004....
- Genome-wide association study identifies variants associated with progression of liver fibrosis from HCV infectionEtienne Patin
Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Necker Medical School, INSERM Unité 980, Paris, France
Gastroenterology 143:1244-52.e1-12. 2012..Only a fraction of patients with chronic HCV infection develop liver fibrosis, a process that might also be affected by genetic factors. We performed a 2-stage GWA study of liver fibrosis progression related to HCV infection...
- Intrahepatic hepatitis C virus RNA quantification in microdissected hepatocytesGiovanna Vona
INSERM U370 Pasteur, Necker Faculty, Paris, France
J Hepatol 40:682-8. 2004..We have therefore investigated the feasibility of quantifying HCV replication using a laser-based microdissection technique...
- Hepatitis C virus core variants isolated from liver tumor but not from adjacent non-tumor tissue interact with Smad3 and inhibit the TGF-beta pathwayNicole Pavio
INSERM U370, Paris V University, Pasteur Institute, 156 rue de Vaugirard 75730 Paris cedex 15, France
Oncogene 24:6119-32. 2005..These results suggest that during chronic infection, there is selection of viral variants that may promote cell transformation by providing, to clonally expanding cells, resistance to TGF-beta antiproliferative effects...
- Hepatitis B virus-related insertional mutagenesis occurs frequently in human liver cancers and recurrently targets human telomerase genePatrizia Paterlini-Brechot
INSERM Pasteur Unit 370, Necker Faculty of Medicine, Necker Enfants Malades Hospital, Paris 75015, France
Oncogene 22:3911-6. 2003..Thus, HBV frequently targets cellular genes involved in cell signalling and some of them may be preferential targets of the viral integration...
- HIP/PAP, a C-type lectin overexpressed in hepatocellular carcinoma, binds the RII alpha regulatory subunit of cAMP-dependent protein kinase and alters the cAMP-dependent protein kinase signallingFrance Demaugre
INSERM U370 CHU Necker Enfants Malades, 75015 Paris, France
Eur J Biochem 271:3812-20. 2004..Thus our findings suggest a novel mechanism for the biological activity of the HIP/PAP lectin...
- Centrosome overduplication, increased ploidy and transformation in cells expressing endoplasmic reticulum-associated cyclin A2Jamila Faivre
INSERM U370, Institut Pasteur Necker, Faculte de Medecine Necker, 75015 Paris, France
Oncogene 21:1493-500. 2002..These results demonstrate that, independently of any viral context, an intracellular redistribution of non-degradable cyclin A2 is capable of deregulating the normal cell cycle to the point where it promotes aneuploidy and cancer...
- Interferon gamma receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infectionBertrand Nalpas
Unité d Hépatologie, Institut National de la Sante et de la Recherche Medicale, U567, Hopital Cochin, Paris, France
Gut 59:1120-6. 2010..Only a minority of patients with chronic hepatitis C virus (HCV) infection develops severe liver fibrosis, a process that may be controlled by human genetic factors...
- Long-term radioiodine retention and regression of liver cancer after sodium iodide symporter gene transfer in wistar ratsJamila Faivre
Department of Liver Cancer and Molecular Virology, Institut National de la Santé et de la Recherche Médicale Unit 370, Paris V University, CHU Necker, Paris, France
Cancer Res 64:8045-51. 2004..This demonstrates for the first time the efficacy of NIS-based radiotherapy in a relevant preclinical model of nonthyroid human carcinogenesis...
- Identification, using cDNA macroarray analysis, of distinct gene expression profiles associated with pathological and virological features of hepatocellular carcinomaOona Delpuech
INSERM U370, CHU Necker Institut Pasteur, 75015, Paris, France
Oncogene 21:2926-37. 2002..Overall, our study supports the hypothesis that despite the heterogeneity of the HCC pattern, the large-scale screening of gene expression may provide data significant to our understanding of the mechanism of liver carcinogenesis...
- Liver cell polyploidization: a pivotal role for binuclear hepatocytesJacques Emmanuel Guidotti
INSERM U370, CHU Necker, 156 rue de Vaugirard, 75015 Paris, France
J Biol Chem 278:19095-101. 2003..This event led only to mononuclear 4n progeny and maintained the tetraploidy status of hepatocytes...
- HIP/PAP accelerates liver regeneration and protects against acetaminophen injury in miceHanh Tu Lieu
Institut National de la Santé et de la Recherche Médicale U 370 Faculté de Médecine, Université Paris 5 Hôpital Necker, Institut Pasteur de Paris, Paris, France
Hepatology 42:618-26. 2005..In conclusion, the present data offer new insights into the biological functions of C-type lectins. In addition, HIP/PAP is a promising candidate for the prevention and treatment of liver failure...
- Severe evolution of chronic hepatitis C in renal transplantation: a case control studyHervé Zylberberg
Service d Hépatologie et INSERM U 370, Hopital Saint Louis, Paris, France
Nephrol Dial Transplant 17:129-33. 2002..To evaluate the impact of kidney transplantation on histopathological progression of hepatitis C virus (HCV)-related liver disease...
- Identification and functional characterization of a new member of the human Mcm protein family: hMcm8Devrim Gozuacik
INSERM Unit 370 Pasteur Institute, Faculte de Medecine Necker Enfants Malades, 156 rue de Vaugirard, 75730, Paris, France
Nucleic Acids Res 31:570-9. 2003..Overall, our data identify a new Mcm protein, which does not form part of the Mcm2-7 complex and which is only structure-bound during S phase, thus suggesting its specific role in DNA replication...
- Liver-stage development of Plasmodium falciparum, in a humanized mouse modelSerban Morosan
Inserm U370 Pasteur Institute, CHU Necker, Paris, France
J Infect Dis 193:996-1004. 2006..Progress has been severely limited by the lack of adequate in vitro and in vivo models...
- Quantitative fluorescence imaging approach for the study of polyploidization in hepatocytesEugenia Lamas
Liver Cancer and Molecular Virology, Institut National de la Sante et de la Recherche Medicale, Unité 370, Paris, France
J Histochem Cytochem 51:319-30. 2003..These results show that the approach of fluorescence imaging is well suited to investigations on polyploidization mechanisms...
- Regression of splenic lymphoma with villous lymphocytes after treatment of hepatitis C virus infectionOlivier Hermine
Department of Hematology and Centre National de la Recherche Scientifique Unité Mixte de Recherche 8603, Hopital Necker, Paris, France
N Engl J Med 347:89-94. 2002..We undertook this study after a patient with splenic lymphoma with villous lymphocytes had a hematologic response after antiviral treatment of HCV infection...
- Reg2 inactivation increases sensitivity to Fas hepatotoxicity and delays liver regeneration post-hepatectomy in miceHanh Tu Lieu
Institut National de la Sante et de la Recherche Medicale, U785, Paris, France
Hepatology 44:1452-64. 2006..Reg2/HIP/PAP is therefore a critical mitogenic and antiapoptotic factor for the liver...
- Reversibility of hepatitis C virus-related cirrhosisStanislas Pol
Unité d Hépatologie, Hopital Necker, Paris, France
Hum Pathol 35:107-12. 2004..In conclusion, long-lasting suppression of the necroinflammatory activity of liver disease and/or antifibrogenetic effects of interferon-alpha may allow regression of cirrhosis...
- Induction or expansion of T-cell responses by a hepatitis B DNA vaccine administered to chronic HBV carriersMaryline Mancini-Bourgine
Carcinogénèse Hépatique et Virologie Moléculaire Institut National de la Santé et de la Recherche Médicale Unité 370, Institut Pasteur, Paris, France
Hepatology 40:874-82. 2004..We demonstrate that DNA vaccination can specifically but transiently activate T-cell responses in some chronic HBV carriers who do not respond to current antiviral therapies...