Christian Brechot

Summary

Country: France

Publications

  1. ncbi Impact of HBV, HCV and GBV-C/HGV on hepatocellular carcinomas in Europe: results of a European concerted action
    C Brechot
    INSERM U370 and Liver Unit, CHU Necker, Paris, France
    J Hepatol 29:173-83. 1998
  2. ncbi Molecular bases for the development of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC)
    C Brechot
    Liver Unit and INSERM U370, CNR Pasteur Necker Institute, Paris, France
    Semin Cancer Biol 10:211-31. 2000
  3. ncbi Pathogenesis of hepatitis B virus-related hepatocellular carcinoma: old and new paradigms
    Christian Brechot
    Liver Unit and INSERM U370, Rene Descartes University, Pasteur Necker Institute, Paris, France
    Gastroenterology 127:S56-61. 2004
  4. ncbi Genome-wide association study identifies variants associated with progression of liver fibrosis from HCV infection
    Etienne Patin
    Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Necker Medical School, INSERM Unité 980, Paris, France
    Gastroenterology 143:1244-52.e1-12. 2012
  5. ncbi Intrahepatic hepatitis C virus RNA quantification in microdissected hepatocytes
    Giovanna Vona
    INSERM U370-Pasteur, Necker Faculty, Paris, France
    J Hepatol 40:682-8. 2004
  6. ncbi Hepatitis C virus core variants isolated from liver tumor but not from adjacent non-tumor tissue interact with Smad3 and inhibit the TGF-beta pathway
    Nicole Pavio
    INSERM U370, Paris V University, Pasteur Institute, 156 rue de Vaugirard 75730 Paris cedex 15, France
    Oncogene 24:6119-32. 2005
  7. ncbi Hepatitis B virus-related insertional mutagenesis occurs frequently in human liver cancers and recurrently targets human telomerase gene
    Patrizia Paterlini-Brechot
    INSERM Pasteur Unit 370, Necker Faculty of Medicine, Necker Enfants Malades Hospital, Paris 75015, France
    Oncogene 22:3911-6. 2003
  8. ncbi HIP/PAP, a C-type lectin overexpressed in hepatocellular carcinoma, binds the RII alpha regulatory subunit of cAMP-dependent protein kinase and alters the cAMP-dependent protein kinase signalling
    France Demaugre
    INSERM U370 CHU Necker Enfants Malades, 75015 Paris, France
    Eur J Biochem 271:3812-20. 2004
  9. ncbi Centrosome overduplication, increased ploidy and transformation in cells expressing endoplasmic reticulum-associated cyclin A2
    Jamila Faivre
    INSERM U370, Institut Pasteur Necker, Faculte de Medecine Necker, 75015 Paris, France
    Oncogene 21:1493-500. 2002
  10. ncbi Interferon gamma receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infection
    Bertrand Nalpas
    Unité d Hépatologie, Institut National de la Sante et de la Recherche Medicale, U567, Hopital Cochin, Paris, France
    Gut 59:1120-6. 2010

Collaborators

Detail Information

Publications22

  1. ncbi Impact of HBV, HCV and GBV-C/HGV on hepatocellular carcinomas in Europe: results of a European concerted action
    C Brechot
    INSERM U370 and Liver Unit, CHU Necker, Paris, France
    J Hepatol 29:173-83. 1998
    ..To investigate the impact of hepatitis B (HBV) and C (HCV) infections on hepatocellular carcinoma (HCC) in Europe...
  2. ncbi Molecular bases for the development of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC)
    C Brechot
    Liver Unit and INSERM U370, CNR Pasteur Necker Institute, Paris, France
    Semin Cancer Biol 10:211-31. 2000
    ..Finally the review by Dr Buendia highlights the emerging issue of liver-cancer genetics...
  3. ncbi Pathogenesis of hepatitis B virus-related hepatocellular carcinoma: old and new paradigms
    Christian Brechot
    Liver Unit and INSERM U370, Rene Descartes University, Pasteur Necker Institute, Paris, France
    Gastroenterology 127:S56-61. 2004
    ....
  4. ncbi Genome-wide association study identifies variants associated with progression of liver fibrosis from HCV infection
    Etienne Patin
    Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Necker Medical School, INSERM Unité 980, Paris, France
    Gastroenterology 143:1244-52.e1-12. 2012
    ..Only a fraction of patients with chronic HCV infection develop liver fibrosis, a process that might also be affected by genetic factors. We performed a 2-stage GWA study of liver fibrosis progression related to HCV infection...
  5. ncbi Intrahepatic hepatitis C virus RNA quantification in microdissected hepatocytes
    Giovanna Vona
    INSERM U370-Pasteur, Necker Faculty, Paris, France
    J Hepatol 40:682-8. 2004
    ..Our results directly demonstrate a positive correlation between serum and intrahepatic viral loads, which therefore provides a reliable reflection of intrahepatic HCV replication...
  6. ncbi Hepatitis C virus core variants isolated from liver tumor but not from adjacent non-tumor tissue interact with Smad3 and inhibit the TGF-beta pathway
    Nicole Pavio
    INSERM U370, Paris V University, Pasteur Institute, 156 rue de Vaugirard 75730 Paris cedex 15, France
    Oncogene 24:6119-32. 2005
    ..These results suggest that during chronic infection, there is selection of viral variants that may promote cell transformation by providing, to clonally expanding cells, resistance to TGF-beta antiproliferative effects...
  7. ncbi Hepatitis B virus-related insertional mutagenesis occurs frequently in human liver cancers and recurrently targets human telomerase gene
    Patrizia Paterlini-Brechot
    INSERM Pasteur Unit 370, Necker Faculty of Medicine, Necker Enfants Malades Hospital, Paris 75015, France
    Oncogene 22:3911-6. 2003
    ..Thus, HBV frequently targets cellular genes involved in cell signalling and some of them may be preferential targets of the viral integration...
  8. ncbi HIP/PAP, a C-type lectin overexpressed in hepatocellular carcinoma, binds the RII alpha regulatory subunit of cAMP-dependent protein kinase and alters the cAMP-dependent protein kinase signalling
    France Demaugre
    INSERM U370 CHU Necker Enfants Malades, 75015 Paris, France
    Eur J Biochem 271:3812-20. 2004
    ..Thus our findings suggest a novel mechanism for the biological activity of the HIP/PAP lectin...
  9. ncbi Centrosome overduplication, increased ploidy and transformation in cells expressing endoplasmic reticulum-associated cyclin A2
    Jamila Faivre
    INSERM U370, Institut Pasteur Necker, Faculte de Medecine Necker, 75015 Paris, France
    Oncogene 21:1493-500. 2002
    ..These results demonstrate that, independently of any viral context, an intracellular redistribution of non-degradable cyclin A2 is capable of deregulating the normal cell cycle to the point where it promotes aneuploidy and cancer...
  10. ncbi Interferon gamma receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infection
    Bertrand Nalpas
    Unité d Hépatologie, Institut National de la Sante et de la Recherche Medicale, U567, Hopital Cochin, Paris, France
    Gut 59:1120-6. 2010
    ..Only a minority of patients with chronic hepatitis C virus (HCV) infection develops severe liver fibrosis, a process that may be controlled by human genetic factors...
  11. ncbi Long-term radioiodine retention and regression of liver cancer after sodium iodide symporter gene transfer in wistar rats
    Jamila Faivre
    Department of Liver Cancer and Molecular Virology, Institut National de la Santé et de la Recherche Médicale Unit 370, Paris V University, CHU Necker, Paris, France
    Cancer Res 64:8045-51. 2004
    ..This demonstrates for the first time the efficacy of NIS-based radiotherapy in a relevant preclinical model of nonthyroid human carcinogenesis...
  12. ncbi Identification, using cDNA macroarray analysis, of distinct gene expression profiles associated with pathological and virological features of hepatocellular carcinoma
    Oona Delpuech
    INSERM U370, CHU Necker/Institut Pasteur, 75015, Paris, France
    Oncogene 21:2926-37. 2002
    ..Overall, our study supports the hypothesis that despite the heterogeneity of the HCC pattern, the large-scale screening of gene expression may provide data significant to our understanding of the mechanism of liver carcinogenesis...
  13. ncbi Liver cell polyploidization: a pivotal role for binuclear hepatocytes
    Jacques-Emmanuel Guidotti
    INSERM U370, CHU Necker, 156 rue de Vaugirard, 75015 Paris, France
    J Biol Chem 278:19095-101. 2003
    ..This event led only to mononuclear 4n progeny and maintained the tetraploidy status of hepatocytes...
  14. ncbi HIP/PAP accelerates liver regeneration and protects against acetaminophen injury in mice
    Hanh Tu Lieu
    Institut National de la Santé et de la Recherche Médicale U 370 Faculté de Médecine, Université Paris 5 Hôpital Necker, Institut Pasteur de Paris, Paris, France
    Hepatology 42:618-26. 2005
    ..In conclusion, the present data offer new insights into the biological functions of C-type lectins. In addition, HIP/PAP is a promising candidate for the prevention and treatment of liver failure...
  15. ncbi Severe evolution of chronic hepatitis C in renal transplantation: a case control study
    Hervé Zylberberg
    Service d Hépatologie et INSERM U 370, Hopital Saint Louis, Paris, France
    Nephrol Dial Transplant 17:129-33. 2002
    ..To evaluate the impact of kidney transplantation on histopathological progression of hepatitis C virus (HCV)-related liver disease...
  16. ncbi Identification and functional characterization of a new member of the human Mcm protein family: hMcm8
    Devrim Gozuacik
    INSERM Unit 370 Pasteur Institute, Faculte de Medecine Necker Enfants Malades, 156 rue de Vaugirard, 75730, Paris, France
    Nucleic Acids Res 31:570-9. 2003
    ..Overall, our data identify a new Mcm protein, which does not form part of the Mcm2-7 complex and which is only structure-bound during S phase, thus suggesting its specific role in DNA replication...
  17. ncbi Liver-stage development of Plasmodium falciparum, in a humanized mouse model
    Serban Morosan
    INSERM U370--Pasteur Institute, CHU Necker, Paris, France
    J Infect Dis 193:996-1004. 2006
    ....
  18. ncbi Quantitative fluorescence imaging approach for the study of polyploidization in hepatocytes
    Eugenia Lamas
    Liver Cancer and Molecular Virology, , , Paris, France
    J Histochem Cytochem 51:319-30. 2003
    ..These results show that the approach of fluorescence imaging is well suited to investigations on polyploidization mechanisms...
  19. ncbi Regression of splenic lymphoma with villous lymphocytes after treatment of hepatitis C virus infection
    Olivier Hermine
    Department of Hematology and Centre National de la Recherche Scientifique Unité Mixte de Recherche 8603, Hopital Necker, Paris, France
    N Engl J Med 347:89-94. 2002
    ..We undertook this study after a patient with splenic lymphoma with villous lymphocytes had a hematologic response after antiviral treatment of HCV infection...
  20. ncbi Reg2 inactivation increases sensitivity to Fas hepatotoxicity and delays liver regeneration post-hepatectomy in mice
    Hanh Tu Lieu
    Institut National de la Sante et de la Recherche Medicale, U785, Paris, France
    Hepatology 44:1452-64. 2006
    ..Reg2/HIP/PAP is therefore a critical mitogenic and antiapoptotic factor for the liver...
  21. ncbi Reversibility of hepatitis C virus-related cirrhosis
    Stanislas Pol
    , , Paris, France
    Hum Pathol 35:107-12. 2004
    ..In conclusion, long-lasting suppression of the necroinflammatory activity of liver disease and/or antifibrogenetic effects of interferon-alpha may allow regression of cirrhosis...
  22. ncbi Induction or expansion of T-cell responses by a hepatitis B DNA vaccine administered to chronic HBV carriers
    Maryline Mancini-Bourgine
    , Institut Pasteur, Paris, France
    Hepatology 40:874-82. 2004
    ..We demonstrate that DNA vaccination can specifically but transiently activate T-cell responses in some chronic HBV carriers who do not respond to current antiviral therapies...