M Christiane Brahimi-Horn

Summary

Country: France

Publications

  1. ncbi request reprint Hypoxia in cancer cell metabolism and pH regulation
    M Christiane Brahimi-Horn
    Institute of Signaling, Developmental Biology and Cancer Research, CNRS UMR 6543, University of Nice, Centre A Lacassagne, 33 Avenue Valombrose, 06189 Nice, France
    Essays Biochem 43:165-78. 2007
  2. ncbi request reprint Hypoxia: the tumor's gateway to progression along the angiogenic pathway
    C Brahimi-Horn
    Institute of Signaling, Developmental Biology and Cancer Research, CNRS UMR 6543, Centre A Lacassagne, 33 Avenue Valombrose, 06189 Nice, France
    Trends Cell Biol 11:S32-6. 2001
  3. doi request reprint Hypoxia and energetic tumour metabolism
    M Christiane Brahimi-Horn
    Institute of Developmental Biology and Cancer Research, University of Nice, CNRS UMR 6543, Centre A Lacassagne, 33 Avenue Valombrose, 06189 Nice, France
    Curr Opin Genet Dev 21:67-72. 2011
  4. ncbi request reprint Hypoxia and cancer
    M Christiane Brahimi-Horn
    Institute of Signaling, Developmental Biology and Cancer Research, University of Nice, CNRS UMR 6543, Centre A Lacassagne, 33 Avenue Valombrose, 06189, Nice, France
    J Mol Med (Berl) 85:1301-7. 2007
  5. ncbi request reprint Oxygen, a source of life and stress
    M Christiane Brahimi-Horn
    Institute of Signaling, Developmental Biology and Cancer Research, University of Nice, CNRS UMR 6543, Centre A Lacassagne, 33 Avenue Valombrose, 06189 Nice, France
    FEBS Lett 581:3582-91. 2007
  6. ncbi request reprint Hypoxia signalling controls metabolic demand
    M Christiane Brahimi-Horn
    Institute of Signaling, Developmental Biology and Cancer Research, CNRS UMR 6543, University of Nice, Centre A Lacassagne, 33 Avenue Valombrose, 06189 Nice, France
    Curr Opin Cell Biol 19:223-9. 2007
  7. ncbi request reprint Harnessing the hypoxia-inducible factor in cancer and ischemic disease
    M Christiane Brahimi-Horn
    Institute of Signaling, Developmental Biology and Cancer Research, CNRS UMR 6543, University of Nice, Centre A Lacassagne, 33 Avenue Valombrose, 06189 Nice, France
    Biochem Pharmacol 73:450-7. 2007
  8. ncbi request reprint The role of the hypoxia-inducible factor in tumor metabolism growth and invasion
    Christiane Brahimi-Horn
    Institute of Signaling, Developmental Biology and Cancer Research, CNRS UMR 6543, University of Nice, Centre A Lacassagne, 33 Avenue Valombrose, 06189 Nice
    Bull Cancer 93:E73-80. 2006
  9. ncbi request reprint When hypoxia signalling meets the ubiquitin-proteasomal pathway, new targets for cancer therapy
    Christiane Brahimi-Horn
    Institute of Signaling, Developmental Biology and Cancer Research, CNRS UMR 6543, Centre A Lacassagne, 33 Avenue Valombrose, 06189 Nice, France
    Crit Rev Oncol Hematol 53:115-23. 2005
  10. ncbi request reprint Signalling via the hypoxia-inducible factor-1alpha requires multiple posttranslational modifications
    Christiane Brahimi-Horn
    Institute of Signaling, Developmental Biology and Cancer Research, CNRS UMR 6543, Centre A Lacassagne, 33 Avenue de Valombrose, 06189 Nice, France
    Cell Signal 17:1-9. 2005

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Hypoxia in cancer cell metabolism and pH regulation
    M Christiane Brahimi-Horn
    Institute of Signaling, Developmental Biology and Cancer Research, CNRS UMR 6543, University of Nice, Centre A Lacassagne, 33 Avenue Valombrose, 06189 Nice, France
    Essays Biochem 43:165-78. 2007
    ..A better understanding of HIF-dependent metabolism and pH regulation in cancer cells should lead to further development of diagnostic tools and novel therapeutics that will bring benefit to cancer patients...
  2. ncbi request reprint Hypoxia: the tumor's gateway to progression along the angiogenic pathway
    C Brahimi-Horn
    Institute of Signaling, Developmental Biology and Cancer Research, CNRS UMR 6543, Centre A Lacassagne, 33 Avenue Valombrose, 06189 Nice, France
    Trends Cell Biol 11:S32-6. 2001
    ....
  3. doi request reprint Hypoxia and energetic tumour metabolism
    M Christiane Brahimi-Horn
    Institute of Developmental Biology and Cancer Research, University of Nice, CNRS UMR 6543, Centre A Lacassagne, 33 Avenue Valombrose, 06189 Nice, France
    Curr Opin Genet Dev 21:67-72. 2011
    ..The targeting of key HIF-1-mediated steps, responsible for exacerbated glycolysis and pHi-control, and of the 'guardian of cellular energy' AMP-kinase should offer novel therapeutic opportunities to fight cancer...
  4. ncbi request reprint Hypoxia and cancer
    M Christiane Brahimi-Horn
    Institute of Signaling, Developmental Biology and Cancer Research, University of Nice, CNRS UMR 6543, Centre A Lacassagne, 33 Avenue Valombrose, 06189, Nice, France
    J Mol Med (Berl) 85:1301-7. 2007
    ..It is hoped that a better understanding of the mechanisms implicated will lead to alternative and more efficient therapeutic approaches...
  5. ncbi request reprint Oxygen, a source of life and stress
    M Christiane Brahimi-Horn
    Institute of Signaling, Developmental Biology and Cancer Research, University of Nice, CNRS UMR 6543, Centre A Lacassagne, 33 Avenue Valombrose, 06189 Nice, France
    FEBS Lett 581:3582-91. 2007
    ..In addition, we will focus on cancer cell hypoxia and on its role in driving cell metabolism, pH regulation and survival...
  6. ncbi request reprint Hypoxia signalling controls metabolic demand
    M Christiane Brahimi-Horn
    Institute of Signaling, Developmental Biology and Cancer Research, CNRS UMR 6543, University of Nice, Centre A Lacassagne, 33 Avenue Valombrose, 06189 Nice, France
    Curr Opin Cell Biol 19:223-9. 2007
    ..This distinctive metabolic nature of cancer cells is already being exploited as a diagnostic tool but is yet to be harnessed as a therapeutic intervention...
  7. ncbi request reprint Harnessing the hypoxia-inducible factor in cancer and ischemic disease
    M Christiane Brahimi-Horn
    Institute of Signaling, Developmental Biology and Cancer Research, CNRS UMR 6543, University of Nice, Centre A Lacassagne, 33 Avenue Valombrose, 06189 Nice, France
    Biochem Pharmacol 73:450-7. 2007
    ..Approaches to either enforce tumour regression or increase blood vessel formation through the targeting of HIF or its downstream effectors will also be discussed...
  8. ncbi request reprint The role of the hypoxia-inducible factor in tumor metabolism growth and invasion
    Christiane Brahimi-Horn
    Institute of Signaling, Developmental Biology and Cancer Research, CNRS UMR 6543, University of Nice, Centre A Lacassagne, 33 Avenue Valombrose, 06189 Nice
    Bull Cancer 93:E73-80. 2006
    ....
  9. ncbi request reprint When hypoxia signalling meets the ubiquitin-proteasomal pathway, new targets for cancer therapy
    Christiane Brahimi-Horn
    Institute of Signaling, Developmental Biology and Cancer Research, CNRS UMR 6543, Centre A Lacassagne, 33 Avenue Valombrose, 06189 Nice, France
    Crit Rev Oncol Hematol 53:115-23. 2005
    ..Inhibition of the proteasome in conjunction with topoisomerase inhibition has shown some promise in the treatment of experimental cancer. Such treatment may impact on the hypoxic adaptation of tumour cells...
  10. ncbi request reprint Signalling via the hypoxia-inducible factor-1alpha requires multiple posttranslational modifications
    Christiane Brahimi-Horn
    Institute of Signaling, Developmental Biology and Cancer Research, CNRS UMR 6543, Centre A Lacassagne, 33 Avenue de Valombrose, 06189 Nice, France
    Cell Signal 17:1-9. 2005
    ..The precise spatio-temporal occurrence of these multiple modifications is still not fully understood but is dependent on the microenvironment and determines the driving force of variable cellular responses...
  11. ncbi request reprint Arrest-defective-1 protein, an acetyltransferase, does not alter stability of hypoxia-inducible factor (HIF)-1alpha and is not induced by hypoxia or HIF
    Rebecca Bilton
    Institute of Signaling, Developmental Biology and Cancer Research, CNRS UMR 6543, Centre A Lacassagne, 33 Avenue Valombrose, Nice 06189, France
    J Biol Chem 280:31132-40. 2005
    ..Taken together, our findings demonstrate that ARD1 has limited, if any, impact on the HIF signaling pathway...
  12. doi request reprint Hypoxic enlarged mitochondria protect cancer cells from apoptotic stimuli
    Johanna Chiche
    Institute of Developmental Biology and Cancer Research, CNRS UMR 6543, Centre Antoine Lacassagne, University of Nice, 06189 Nice, France
    J Cell Physiol 222:648-57. 2010
    ....
  13. doi request reprint Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH
    Johanna Chiche
    Institute of Developmental Biology and Cancer Research University of Nice, Centre National de la Recherche Scientifique UMR 6543, Centre A Lacassagne, 33 Avenue Valombrose, Nice, France
    Cancer Res 69:358-68. 2009
    ..Thus, hypoxia-induced CAIX and CAXII are major tumor prosurvival pH(i)-regulating enzymes, and their combined targeting shows that they hold potential as anticancer targets...
  14. ncbi request reprint The oxygen sensor factor-inhibiting hypoxia-inducible factor-1 controls expression of distinct genes through the bifunctional transcriptional character of hypoxia-inducible factor-1alpha
    Frédéric Dayan
    Institute of Signaling, Developmental Biology and Cancer Research, Centre National de la Recherche Scientifique, UMR 6543, Universite de Nice, Centre Antoine Lacassagne, 33 Avenue de Valombrose, 06189 Nice, France
    Cancer Res 66:3688-98. 2006
    ..We propose that the oxygen-sensitive attenuator FIH, together with two distinct TADs, is central in setting the gene expression repertoire dictated by the cell pO(2)...
  15. ncbi request reprint Expression of a truncated active form of VDAC1 in lung cancer associates with hypoxic cell survival and correlates with progression to chemotherapy resistance
    M Christiane Brahimi-Horn
    Institute of Developmental Biology and Cancer Research, University of Nice, CNRS UMR 6543, Centre Antoine Lacassagne, Nice, France
    Cancer Res 72:2140-50. 2012
    ..VDAC1-ΔC may also hold promise as a biomarker for tumor progression in chemotherapy-resistant patients...
  16. doi request reprint Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer
    Johanna Chiche
    Institute of Developmental Biology and Cancer Research, University of Nice, CNRS UMR, Centre A Lacassagne, Nice, France
    J Cell Mol Med 14:771-94. 2010
    ..We will summarize strategies that take advantage of intracellular and extracellular pH regulation to target the primary tumour and metastatic growth, and to turn around resistance to chemotherapy and radiotherapy...
  17. ncbi request reprint SUMOylation of hypoxia-inducible factor-1alpha reduces its transcriptional activity
    Melanie A Berta
    Institute of Signalling, Developmental Biology and Cancer Research, University of Nice, CNRS UMR 6543, Centre A Lacassagne, 33 Avenue Valombrose, 06189 Nice, France
    Biochem Biophys Res Commun 360:646-52. 2007
    ..These results indicate that when HIF-1alpha is conjugated to SUMO its transcriptional activity is decreased and that this is not mediated by a change in the protein's half-life...
  18. ncbi request reprint The hypoxia-inducible factor and tumor progression along the angiogenic pathway
    M Christiane Brahimi-Horn
    Institute of Signaling, Developmental Biology and Cancer Research, CNRS UMR 6543, Centre A Lacassagne, 06189 Nice, France
    Int Rev Cytol 242:157-213. 2005
    ..HIF in turn targets genes that induce survival, glycolysis, and angiogenesis, a form of neovascularization, which ensures the tumor with a continued supply of oxygen and nutrients for further growth...
  19. ncbi request reprint Hypoxic VDAC1: a potential mitochondrial marker for cancer therapy
    M Christiane Brahimi-Horn
    Institute for Research on Cancer and Aging, Nice IRCAN, CNRS UMR7284, INSERM U1081, University of Nice, Nice, France
    Adv Exp Med Biol 772:101-10. 2014
    ..Furthermore, VDAC1-ΔC was detected in tissues of 50 % of 46 patients with lung cancer. This review examines the significance of this new form of VDAC1 for anticancer therapy...
  20. ncbi request reprint HIF-1: master and commander of the hypoxic world. A pharmacological approach to its regulation by siRNAs
    Nathalie M Mazure
    Institute of Signaling, Developmental Biology and Cancer Research, CNRS UMR 6543, Centre Antoine Lacassagne, 33 Avenue de Valombrose, 06189 Nice, France
    Biochem Pharmacol 68:971-80. 2004
    ..We will introduce the different actors involved in HIF-1 regulation, and their mechanisms of action via invalidation by siRNAs and discuss therapies targeting HIF-1, to selectively kill tumor cells that adapt to low O2 concentrations...
  21. ncbi request reprint ARDent about acetylation and deacetylation in hypoxia signalling
    Rebecca Bilton
    Institute of Signaling, Developmental Biology and Cancer Research CNRS UMR 6543, University of Nice, Centre A Lacassagne, 33 Avenue Valombrose, 06189 Nice, France
    Trends Cell Biol 16:616-21. 2006
    ..Nonetheless, the observation that small-molecule inhibitors of HDACs have anti-angiogenic activity suggests that acetylation and deacetylation of HIF or HIF modifiers represents a potential target in cancer therapy...
  22. ncbi request reprint [Regulation of the Hypoxia-Inducible Factor-1alpha (HIF-1alpha): a breath of fresh air in hypoxia research]
    Mélanie Berta
    Institute of Signaling Developmental Biology and Cancer, CNRS UMR6543, Centre Antoine Lacassagne, 33 Avenue de Valombrose, 06189 Nice cedex, France
    J Soc Biol 198:113-20. 2004
    ..In this review, we will discuss in particular the multiple post-translational modifications regulating HIF-1alpha activity...
  23. pmc A dialogue between the hypoxia-inducible factor and the tumor microenvironment
    Frédéric Dayan
    Institute of Signaling, Developmental Biology and Cancer Research, University of Nice, CNRS UMR 6543, Centre A Lacassagne, 33 Avenue Valombrose, Nice, France
    Cancer Microenviron 1:53-68. 2008
    ....