Lsabelle Boutron

Summary

Country: France

Publications

  1. pmc Knee arthroplasty: disabilities in comparison to the general population and to hip arthroplasty using a French national longitudinal survey
    Agnes Dechartres
    INSERM, U738, Paris, France
    PLoS ONE 3:e2561. 2008
  2. pmc Applicability and generalisability of published results of randomised controlled trials and non-randomised studies evaluating four orthopaedic procedures: methodological systematic review
    Leslie Pibouleau
    INSERM U738, Paris, France
    BMJ 339:b4538. 2009
  3. pmc Reporting of harm in randomized controlled trials evaluating stents for percutaneous coronary intervention
    Morgane Ethgen
    INSERM, U738, Paris, F 75018 France
    Trials 10:29. 2009
  4. ncbi request reprint Extending the CONSORT statement to randomized trials of nonpharmacologic treatment: explanation and elaboration
    Isabelle Boutron
    INSERM U738, AP HP, Hopital Bichat Claude Bernard, and Université Paris 7 Denis Diderot, Paris, France
    Ann Intern Med 148:295-309. 2008
  5. ncbi request reprint Methods and processes of the CONSORT Group: example of an extension for trials assessing nonpharmacologic treatments
    Isabelle Boutron
    INSERM U738, AP HP, Hopital Bichat Claude Bernard, and Université Paris 7 Denis Diderot, Paris, France
    Ann Intern Med 148:W60-6. 2008
  6. doi request reprint Size-adjusted left ventricular outflow tract diameter reference values: a safeguard for the evaluation of the severity of aortic stenosis
    Mohamed Leye
    AP HP, Cardiology Department, Bichat Hospital, Paris, France
    J Am Soc Echocardiogr 22:445-51. 2009
  7. ncbi request reprint Splint for base-of-thumb osteoarthritis: a randomized trial
    Francois Rannou
    Assistance Publique Hopitaux de Paris, Hopital Cochin, Paris, France
    Ann Intern Med 150:661-9. 2009
  8. pmc Reporting methods of blinding in randomized trials assessing nonpharmacological treatments
    Isabelle Boutron
    INSERM, U738, Paris, France
    PLoS Med 4:e61. 2007
  9. ncbi request reprint Evolution of disability in adults with hip arthroplasty: a national longitudinal study
    Agnes Dechartres
    INSERM, U738, Universite Paris 7, UFR de Medecine, AP HP Hôpital Bichat, Département d Epidémiologie, Biostatistique et Recherche Clinique, Paris, France
    Arthritis Rheum 57:364-71. 2007
  10. ncbi request reprint A checklist to evaluate a report of a nonpharmacological trial (CLEAR NPT) was developed using consensus
    Isabelle Boutron
    INSERM U738, Paris, France
    J Clin Epidemiol 58:1233-40. 2005

Detail Information

Publications39

  1. pmc Knee arthroplasty: disabilities in comparison to the general population and to hip arthroplasty using a French national longitudinal survey
    Agnes Dechartres
    INSERM, U738, Paris, France
    PLoS ONE 3:e2561. 2008
    ..A secondary objective was to compare the level of disabilities of people with knee to people with hip arthroplasty...
  2. pmc Applicability and generalisability of published results of randomised controlled trials and non-randomised studies evaluating four orthopaedic procedures: methodological systematic review
    Leslie Pibouleau
    INSERM U738, Paris, France
    BMJ 339:b4538. 2009
    ..To compare the reporting of essential applicability data from randomised controlled trials and non-randomised studies evaluating four new orthopaedic surgical procedures...
  3. pmc Reporting of harm in randomized controlled trials evaluating stents for percutaneous coronary intervention
    Morgane Ethgen
    INSERM, U738, Paris, F 75018 France
    Trials 10:29. 2009
    ..The aim of this study was to assess the reporting of harm in randomized controlled trials evaluating stents for percutaneous coronary intervention...
  4. ncbi request reprint Extending the CONSORT statement to randomized trials of nonpharmacologic treatment: explanation and elaboration
    Isabelle Boutron
    INSERM U738, AP HP, Hopital Bichat Claude Bernard, and Université Paris 7 Denis Diderot, Paris, France
    Ann Intern Med 148:295-309. 2008
    ..This extension, in conjunction with the main CONSORT Statement and other CONSORT extensions, should help to improve the reporting of RCTs performed in this field...
  5. ncbi request reprint Methods and processes of the CONSORT Group: example of an extension for trials assessing nonpharmacologic treatments
    Isabelle Boutron
    INSERM U738, AP HP, Hopital Bichat Claude Bernard, and Université Paris 7 Denis Diderot, Paris, France
    Ann Intern Med 148:W60-6. 2008
    ..The conduct of randomized, controlled trials of nonpharmacologic treatments presents specific challenges that are not adequately addressed in trial reports...
  6. doi request reprint Size-adjusted left ventricular outflow tract diameter reference values: a safeguard for the evaluation of the severity of aortic stenosis
    Mohamed Leye
    AP HP, Cardiology Department, Bichat Hospital, Paris, France
    J Am Soc Echocardiogr 22:445-51. 2009
    ..Transesophageal echocardiography (TEE) is reputed to be more accurate than transthoracic echocardiography (TTE), but validation studies are rare. A safeguard for LVOTd measurements is thus desirable...
  7. ncbi request reprint Splint for base-of-thumb osteoarthritis: a randomized trial
    Francois Rannou
    Assistance Publique Hopitaux de Paris, Hopital Cochin, Paris, France
    Ann Intern Med 150:661-9. 2009
    ..Some guidelines recommend splinting for base-of-thumb osteoarthritis, despite lack of evidence of efficacy...
  8. pmc Reporting methods of blinding in randomized trials assessing nonpharmacological treatments
    Isabelle Boutron
    INSERM, U738, Paris, France
    PLoS Med 4:e61. 2007
    ..The purpose of this study was to systematically describe the strategies used to obtain blinding in a sample of randomized controlled trials of nonpharmacological treatment...
  9. ncbi request reprint Evolution of disability in adults with hip arthroplasty: a national longitudinal study
    Agnes Dechartres
    INSERM, U738, Universite Paris 7, UFR de Medecine, AP HP Hôpital Bichat, Département d Epidémiologie, Biostatistique et Recherche Clinique, Paris, France
    Arthritis Rheum 57:364-71. 2007
    ..To describe disability in individuals with hip arthroplasty and its evolution over 2 years compared with that in the general population, and to compare the degree of disability between subjects with recent and older hip arthroplasty...
  10. ncbi request reprint A checklist to evaluate a report of a nonpharmacological trial (CLEAR NPT) was developed using consensus
    Isabelle Boutron
    INSERM U738, Paris, France
    J Clin Epidemiol 58:1233-40. 2005
    ..To develop a checklist of items measuring the quality of reports of randomized clinical trials (RCTs) assessing nonpharmacological treatments (NPTs)...
  11. doi request reprint Comparison of registered and published primary outcomes in randomized controlled trials
    Sylvain Mathieu
    INSERM, U738, Assistance Publique des Hopitaux de Paris, Hopital Bichat Claude Bernard, Département d Epidémiologie Biostatistique et Recherche Clinique, Paris, France
    JAMA 302:977-84. 2009
    ..As of 2005, the International Committee of Medical Journal Editors required investigators to register their trials prior to participant enrollment as a precondition for publishing the trial's findings in member journals...
  12. pmc The reporting of randomized clinical trials using a surgical intervention is in need of immediate improvement: a systematic review
    Isabelle Jacquier
    INSERM U738, Paris France corrected Assistance Publique Hôpitaux de Paris APHP, Groupe Hospitalier Bichat Claude Bernard, Département d Epidémiologie Biostatistique et Recherche Clinique, Paris, France
    Ann Surg 244:677-83. 2006
    ..To assess the reporting of surgical interventions, care providers, and number of centers in randomized clinical trials...
  13. pmc Methods of blinding in reports of randomized controlled trials assessing pharmacologic treatments: a systematic review
    Isabelle Boutron
    INSERM U738, Paris, France
    PLoS Med 3:e425. 2006
    ....
  14. doi request reprint Reporting of safety results in published reports of randomized controlled trials
    Isabelle Pitrou
    Département d Epidémiologie, Biostatistique, et Recherche Clinique, Groupe Hospitalier Bichat Claude Bernard AP HP, Universite Denis Diderot, INSERM U738, Paris, France
    Arch Intern Med 169:1756-61. 2009
    ..Poor safety reporting can lead to misinterpretation and inadequate conclusions about the interventions assessed. Our aim was to describe the reporting of harm-related results from randomized controlled trials (RCTs)...
  15. doi request reprint Inadequate planning and reporting of adjudication committees in clinical trials: recommendation proposal
    Agnes Dechartres
    INSERM U738, Paris, France
    J Clin Epidemiol 62:695-702. 2009
    ..We aimed to assess the reporting and functioning of ACs (synonyms: clinical event committees, endpoint committees) in clinical trials...
  16. ncbi request reprint Half of elderly patients routinely treated for colorectal cancer receive a sub-standard treatment
    Thomas Aparicio
    Service d Hepato Gastroenterologie, AP HP, Hopital Bichat, Universite Denis Diderot, Paris 7, UFR de Medecine, Paris, France
    Crit Rev Oncol Hematol 71:249-57. 2009
    ..Several database studies report a lack of care in elderly patients with colorectal cancer...
  17. pmc Reporting of radiographic methods in randomised controlled trials assessing structural outcomes in rheumatoid arthritis
    Gabriel Baron
    Département d Epidémiologie Biostatistique et Recherche Clinique, INSERM, U738, Groupe Hospitalier Bichat Claude Bernard, 46 rue Henri Huchard, 75018 Paris, France
    Ann Rheum Dis 66:651-7. 2007
    ....
  18. pmc Applicability and generalisability of the results of systematic reviews to public health practice and policy: a systematic review
    Nizar Ahmad
    Centre d Epidemiologie Clinique, Hopital Hotel Dieu, AP HP Assistance Publique des Hôpitaux de Paris, 1 Place du Parvis Notre Dame, Paris 75181, France
    Trials 11:20. 2010
    ..e., whether the results of a trial can be reasonably applied or generalized to a definable group of patients in a particular setting in routine practice, also called external validity or generalisability)...
  19. ncbi request reprint Reporting and interpretation of randomized controlled trials with statistically nonsignificant results for primary outcomes
    Isabelle Boutron
    Centre for Statistics in Medicine, University of Oxford, Oxford, United Kingdom
    JAMA 303:2058-64. 2010
    ..Previous studies indicate that the interpretation of trial results can be distorted by authors of published reports...
  20. ncbi request reprint Primer: assessing the efficacy and safety of nonpharmacologic treatments for chronic rheumatic diseases
    Philippe Ravaud
    University of Paris VII, Paris, France
    Nat Clin Pract Rheumatol 2:313-9. 2006
    ....
  21. pmc Geographical representativeness of published and ongoing randomized controlled trials. The example of: Tobacco consumption and HIV infection
    Nizar Ahmad
    INSERM, U738, Paris, France
    PLoS ONE 6:e16878. 2011
    ..This study aimed to compare where research is conducted to where research is needed for 2 public health priorities: tobacco consumption and HIV infection...
  22. pmc Neglected external validity in reports of randomized trials: the example of hip and knee osteoarthritis
    Nizar Ahmad
    INSERM U738, Assistance Publique Hopitaux de Paris, Hopital Bichat Claude Bernard, Universite Paris 7, Paris, France
    Arthritis Rheum 61:361-9. 2009
    ..To evaluate data reporting related to external validity from randomized controlled trials (RCTs) assessing pharmacologic and nonpharmacologic treatment for hip and knee osteoarthritis (OA)...
  23. doi request reprint Provider and center effect in multicenter randomized controlled trials of surgical specialties: an analysis on patient-level data
    David J Biau
    Departement de Biostatistique et Informatique Medicale, Hopital Saint Louis, Paris, France
    Ann Surg 247:892-8. 2008
    ..To estimate the importance of center and provider effect and its implication on the estimation of treatment effect in surgical randomized controlled trials...
  24. pmc Patients' and practitioners' views of knee osteoarthritis and its management: a qualitative interview study
    Sophie Alami
    Interlis, Universite Paris Descartes, Paris, France
    PLoS ONE 6:e19634. 2011
    ..To identify the views of patients and care providers regarding the management of knee osteoarthritis (OA) and to reveal potential obstacles to improving health care strategies...
  25. doi request reprint Single-center trials show larger treatment effects than multicenter trials: evidence from a meta-epidemiologic study
    Agnes Dechartres
    U738 INSERM, Paris, France
    Ann Intern Med 155:39-51. 2011
    ..A recent study suggested that results of single-center trials are frequently contradicted when similar trials are performed in multicenter settings...
  26. doi request reprint The account for provider and center effects in multicenter interventional and surgical randomized controlled trials is in need of improvement: a review
    David J Biau
    INSERM U717 Departement de Biostatistique et Informatique Médicale, Hôpital Saint Louis Université Paris 7, Paris, France
    J Clin Epidemiol 61:435-9. 2008
    ..To systematically review the account of center and provider effects in large surgical and interventional randomized controlled trials...
  27. ncbi request reprint High-sensitivity C-reactive protein in chronic low back pain with vertebral end-plate Modic signal changes
    Francois Rannou
    Assistance Publique Hopitaux de Paris, Universite Rene Descartes, Groupe Hospitalier Cochin, Paris, France
    Arthritis Rheum 57:1311-5. 2007
    ..To assess high-sensitivity C-reactive protein (hsCRP) level as a measure of low-grade inflammation in relation to Modic vertebral end-plate marrow signal change on magnetic resonance imaging (MRI) in patients with chronic low back pain...
  28. pmc Quality of reporting internal and external validity data from randomized controlled trials evaluating stents for percutaneous coronary intervention
    Morgane Ethgen
    Institut National de la Santé et la Recherche Médiale, INSERM U738, Paris, France
    BMC Med Res Methodol 9:24. 2009
    ..The objective of our study was to evaluate the quality of reporting internal and external validity data in published reports of RCTs assessing the stents for percutaneous coronary interventions...
  29. doi request reprint Usefulness of the right parasternal view and non-imaging continuous-wave Doppler transducer for the evaluation of the severity of aortic stenosis in the modern area
    Caroline Cueff de Monchy
    AP HP, Cardiology Department, Bichat Hospital, Paris, France
    Eur J Echocardiogr 10:420-4. 2009
    ..Our aim was to evaluate the additional diagnostic value of the use of NI-CWD and the right parasternal view for the evaluation of AS severity in the modern area...
  30. ncbi request reprint A review of blinding in randomized controlled trials found results inconsistent and questionable
    Isabelle Boutron
    INSERM, U738, Paris, France
    J Clin Epidemiol 58:1220-6. 2005
    ..To determine methods to assess the success of blinding in randomized controlled trials (RCTs)...
  31. doi request reprint Diagnostic accuracy of serum hepcidin for iron deficiency in critically ill patients with anemia
    Sigismond Lasocki
    Service de Réanimation Chirugicale, département d anesthésie réanimation chirurgicale, AP HP, CHU Bichat Claude Bernard, université Paris 7 Diderot, 46, rue Henri Huchard, 75877, Paris Cedex 18, France
    Intensive Care Med 36:1044-8. 2010
    ..We conducted a prospective observational study to determine the cutoff value and diagnostic accuracy of hepcidin levels for detecting ID in critically ill anemic patients...
  32. ncbi request reprint Violation of the intent-to-treat principle and rate of missing data in superiority trials assessing structural outcomes in rheumatic diseases
    Gabriel Baron
    INSERM U 738, Groupe Hospitalier Bichat Claude Bernard, Assistance Publique Hopitaux de Paris, Paris, France
    Arthritis Rheum 52:1858-65. 2005
    ..To evaluate the methodologic quality of and identify methodologic issues in superiority trials assessing structural outcomes in rheumatic diseases...
  33. ncbi request reprint Methodological differences in clinical trials evaluating nonpharmacological and pharmacological treatments of hip and knee osteoarthritis
    Isabelle Boutron
    Département d Epidémiologie, Biostatistique et Recherche Clinique, Groupe Hospitalier Bichat Claude Bernard, Assistance Publique des Hopitaux de Paris, Faculte Xavier Bichat, Universite Paris VII, Paris, France
    JAMA 290:1062-70. 2003
    ....
  34. ncbi request reprint [Rehabilitation on effort of low back pain. Functional restoration programs]
    Serge Poiraudeau
    Service de rééducation et de réadaptation fonctionnelle de l appareil locomoteur et des pathologies du rachis, Groupe Hospitalier Cochin, Paris
    Presse Med 33:413-8. 2004
    ..Finally, results of functional restoration programs in term of return-to-work rate probably strongly depend on the social security system of the country in which such programs have been developed...
  35. ncbi request reprint Methodological issues in trials assessing primary prophylaxis of venous thrombo-embolism
    Gabriel Thabut
    Département d Epidémiologie, Biostatistique et Recherche Clinique, Groupe Hospitalier Bichat Claude Bernard, Faculte Xavier Bichat, Universite Paris VII, Cedex 18, 75877 Paris, France
    Eur Heart J 27:227-36. 2006
    ..Some of these trials have been subject to methodological criticisms. We aimed to assess the methodological issues raised by VTE trials...
  36. pmc Inappropriateness of randomised trials for complex phenomena: single trial is never enough evidence to base decisions on
    Isabelle Boutron
    BMJ 330:94; author reply 95. 2005
  37. ncbi request reprint Blinding was judged more difficult to achieve and maintain in nonpharmacologic than pharmacologic trials
    Isabelle Boutron
    INSERM EMI 03 57, Département d Epidémiologie, Biostatistique et Recherche Clinique, Groupe Hospitalier Bichat Claude Bernard, Assistance Publique Hopitaux de Paris, Faculte Xavier Bichat, Universite Paris 7, France
    J Clin Epidemiol 57:543-50. 2004
    ..To compare the feasibility of blinding and the perceived risk of unblinding in trials evaluating pharmacologic (PT) and nonpharmacologic treatments (NPT) of hip or knee osteoarthritis...
  38. ncbi request reprint Reporting of harm in randomized, controlled trials of nonpharmacologic treatment for rheumatic disease
    Morgane Ethgen
    Centre Hospitalier Universitaire de Hautepierre, Strasbourg, France
    Ann Intern Med 143:20-5. 2005
    ..Reports of clinical trials usually emphasize benefits and give less attention to harms...