Jean Bousquet

Summary

Country: France

Publications

  1. ncbi request reprint Allergy and asthma: from the bedside to the bench and international actions
    Jean Bousquet
    Service des Maladies Respiratoires, INSERM, Hopital Arnaud de Villeneuve, Montpellier Cedex 05, France
    Pol Arch Med Wewn 118:363-6. 2008
  2. pmc Systems medicine and integrated care to combat chronic noncommunicable diseases
    Jean Bousquet
    Department of Respiratory Diseases, Arnaud de Villeneuve Hospital, CHU Montpellier, INSERM CESP U1018, Villejuif, France
    Genome Med 3:43. 2011
  3. pmc Birth cohorts in asthma and allergic diseases: report of a NIAID/NHLBI/MeDALL joint workshop
    Jean Bousquet
    University Hospital, Montpellier and INSERM U1018, Villejuif, France Electronic address
    J Allergy Clin Immunol 133:1535-46. 2014
  4. doi request reprint Randomized controlled trial of desloratadine for persistent allergic rhinitis: correlations between symptom improvement and quality of life
    Jean Bousquet
    Hopital Arnaud de Villeneuve, Montpellier, France
    Allergy Asthma Proc 34:274-82. 2013
  5. doi request reprint Pooling birth cohorts in allergy and asthma: European Union-funded initiatives - a MeDALL, CHICOS, ENRIECO, and GA²LEN joint paper
    Jean Bousquet
    University Hospital, Hopital Arnaud de Villeneuve, Montpellier, France
    Int Arch Allergy Immunol 161:1-10. 2013
  6. doi request reprint Allergic Rhinitis and its Impact on Asthma (ARIA): achievements in 10 years and future needs
    J Bousquet
    J Allergy Clin Immunol 130:1049-62. 2012
  7. ncbi request reprint Severe chronic allergic (and related) diseases: a uniform approach--a MeDALL--GA2LEN--ARIA position paper
    J Bousquet
    Centre Hospitalier Universitaire Montpellier, Montpellier Cedex 05, France
    Int Arch Allergy Immunol 158:216-31. 2012
  8. ncbi request reprint Establishing the place in therapy of bilastine in the treatment of allergic rhinitis according to ARIA: evidence review
    Jean Bousquet
    University Hospital, Department of Respiratory Diseases, Hopital Arnaud de Villeneuve, Montpellier, France
    Curr Med Res Opin 28:131-9. 2012
  9. doi request reprint Change in visual analog scale score in a pragmatic randomized cluster trial of allergic rhinitis
    Philippe Jean Bousquet
    Service des Maladies Respiratoires, Hopital Arnaud de Villeneuve, Montpellier, France
    J Allergy Clin Immunol 123:1349-54. 2009
  10. ncbi request reprint Montelukast in guidelines and beyond
    Jean Bousquet
    Service des Maladies Respiratoires, Hopital Arnaud de Villeneuve, 371 Avenue Doyen Gaston Giraud, 34275 Montpellier, Cedex 5, France
    Adv Ther 26:575-87. 2009

Collaborators

Detail Information

Publications88

  1. ncbi request reprint Allergy and asthma: from the bedside to the bench and international actions
    Jean Bousquet
    Service des Maladies Respiratoires, INSERM, Hopital Arnaud de Villeneuve, Montpellier Cedex 05, France
    Pol Arch Med Wewn 118:363-6. 2008
    ..From research, public health programs can be designed...
  2. pmc Systems medicine and integrated care to combat chronic noncommunicable diseases
    Jean Bousquet
    Department of Respiratory Diseases, Arnaud de Villeneuve Hospital, CHU Montpellier, INSERM CESP U1018, Villejuif, France
    Genome Med 3:43. 2011
    ..This systems medicine strategy, which will take a holistic approach to disease, is designed to allow the results to be used globally, taking into account the needs and specificities of local economies and health systems...
  3. pmc Birth cohorts in asthma and allergic diseases: report of a NIAID/NHLBI/MeDALL joint workshop
    Jean Bousquet
    University Hospital, Montpellier and INSERM U1018, Villejuif, France Electronic address
    J Allergy Clin Immunol 133:1535-46. 2014
    ..eu), where the reader will find tables describing the characteristics of the birth cohorts included in this report, the type of data collected at differing ages, and a selected bibliography provided by the participating birth cohorts...
  4. doi request reprint Randomized controlled trial of desloratadine for persistent allergic rhinitis: correlations between symptom improvement and quality of life
    Jean Bousquet
    Hopital Arnaud de Villeneuve, Montpellier, France
    Allergy Asthma Proc 34:274-82. 2013
    ..Continuous daily treatment of moderate-to-severe PER with desloratadine at 5 mg/day significantly improved symptoms, which correlated positively, albeit moderately, with QOL benefits and reversal of functional impairments caused by PER...
  5. doi request reprint Pooling birth cohorts in allergy and asthma: European Union-funded initiatives - a MeDALL, CHICOS, ENRIECO, and GA²LEN joint paper
    Jean Bousquet
    University Hospital, Hopital Arnaud de Villeneuve, Montpellier, France
    Int Arch Allergy Immunol 161:1-10. 2013
    ..The aim of this paper is to review current and past EU-funded projects in order to make a summary of their goals and achievements and to suggest future research needs of these European birth cohort networks...
  6. doi request reprint Allergic Rhinitis and its Impact on Asthma (ARIA): achievements in 10 years and future needs
    J Bousquet
    J Allergy Clin Immunol 130:1049-62. 2012
    ....
  7. ncbi request reprint Severe chronic allergic (and related) diseases: a uniform approach--a MeDALL--GA2LEN--ARIA position paper
    J Bousquet
    Centre Hospitalier Universitaire Montpellier, Montpellier Cedex 05, France
    Int Arch Allergy Immunol 158:216-31. 2012
    ....
  8. ncbi request reprint Establishing the place in therapy of bilastine in the treatment of allergic rhinitis according to ARIA: evidence review
    Jean Bousquet
    University Hospital, Department of Respiratory Diseases, Hopital Arnaud de Villeneuve, Montpellier, France
    Curr Med Res Opin 28:131-9. 2012
    ..Several criteria should be met by oral H(1)-antihistamines in terms of their pharmacological, and clinical efficacy and safety profiles...
  9. doi request reprint Change in visual analog scale score in a pragmatic randomized cluster trial of allergic rhinitis
    Philippe Jean Bousquet
    Service des Maladies Respiratoires, Hopital Arnaud de Villeneuve, Montpellier, France
    J Allergy Clin Immunol 123:1349-54. 2009
    ..Most patients with allergic rhinitis consult in primary care. A simple test is needed to evaluate globally the severity of allergic rhinitis to assess the efficacy of treatment...
  10. ncbi request reprint Montelukast in guidelines and beyond
    Jean Bousquet
    Service des Maladies Respiratoires, Hopital Arnaud de Villeneuve, 371 Avenue Doyen Gaston Giraud, 34275 Montpellier, Cedex 5, France
    Adv Ther 26:575-87. 2009
    ..This review includes new studies that have not yet been considered in guidelines...
  11. ncbi request reprint Unmet needs in severe chronic upper airway disease (SCUAD)
    Jean Bousquet
    University Hospital, Montpellier, France
    J Allergy Clin Immunol 124:428-33. 2009
    ..This document can also serve to optimize the pharmacoeconomic evaluation of SCUADs by means of comparison with mild chronic upper airway diseases...
  12. doi request reprint Prioritised research agenda for prevention and control of chronic respiratory diseases
    J Bousquet
    Service des Maladies Respiratories Hopital Arnaud De Villeneuve, 34295 Montpellier Cedex 5, France
    Eur Respir J 36:995-1001. 2010
    ..This requires both CRD-targeted interventions and transverse NCD programmes which include CRDs, with emphasis on health promotion and disease prevention...
  13. ncbi request reprint Efficacy of desloratadine in persistent allergic rhinitis - a GA²LEN study
    Jean Bousquet
    University Hospital, Hopital Arnaud de Villeneuve, Montpellier, France
    Int Arch Allergy Immunol 153:395-402. 2010
    ..There had been no placebo-controlled, randomized, clinical trial of desloratadine (DL) in patients with persistent allergic rhinitis to date...
  14. doi request reprint Development and implementation of guidelines in allergic rhinitis – an ARIA-GA2LEN paper
    Jean Bousquet
    University Hospital, Hopital Arnaud de Villeneuve, Montpellier Cedex 5, France
    Allergy 65:1212-21. 2010
    ..Guidelines must be updated as new management options become available or important new evidence emerges. Transparent reporting of guidelines facilitates understanding and acceptance, but implementation strategies need to be improved...
  15. doi request reprint Uniform definition of asthma severity, control, and exacerbations: document presented for the World Health Organization Consultation on Severe Asthma
    Jean Bousquet
    University Hospital, Hopital Arnaud de Villeneuve, Montpellier, France
    J Allergy Clin Immunol 126:926-38. 2010
    ..The last group includes asthma for which control is not achieved despite the highest level of recommended treatment and asthma for which control can be maintained only with the highest level of recommended treatment...
  16. doi request reprint The Consolidated Standards of Reporting Trials (CONSORT) Statement applied to allergen-specific immunotherapy with inhalant allergens: a Global Allergy and Asthma European Network (GA(2)LEN) article
    Philippe J Bousquet
    Department of Respiratory Diseases, University Hospital of Montpellier, Montpellier, France
    J Allergy Clin Immunol 127:49-56, 56.e1-11. 2011
    ..Randomized trials provide evidence to inform treatment decisions. The Consolidated Standards of Reporting Trials (CONSORT) Statement is a set of recommendations for the reporting of trials...
  17. ncbi request reprint Biologics in asthma: difficulties and drawbacks
    Jean Bousquet
    Hopital Arnaud de Villeneuve, Service des Maladies Respiratoires, 34295 Montpellier, Cedex 05, France
    Expert Opin Biol Ther 8:1921-8. 2008
    ..Biologics have become an increasingly important class of therapeutic compounds in a variety of immune and/or inflammatory diseases. Patients with severe uncontrolled asthma represent a significant unmet need...
  18. doi request reprint Practical guide to skin prick tests in allergy to aeroallergens
    J Bousquet
    Department of Respiratory Diseases, University Hospital, Hopital Arnaud de Villeneuve, Montpellier, France
    Allergy 67:18-24. 2012
    ..The recommendations cover skin test methodology and interpretation, allergen extracts to be used, as well as indications in a variety of settings including paediatrics and developing countries...
  19. doi request reprint How to design and evaluate randomized controlled trials in immunotherapy for allergic rhinitis: an ARIA-GA(2) LEN statement
    Jean Bousquet
    University Hospital, Hopital Arnaud de Villeneuve, Montpellier, France
    Allergy 66:765-74. 2011
    ..It also provides some suggestions for the research that will be needed. Interestingly, some of the research questions can be approached with the available data obtained from large RCTs...
  20. doi request reprint MeDALL (Mechanisms of the Development of ALLergy): an integrated approach from phenotypes to systems medicine
    J Bousquet
    University Hospital, Department of Respiratory Diseases, Hopital Arnaud de Villeneuve, Montpellier, France
    Allergy 66:596-604. 2011
    ....
  21. ncbi request reprint Asthma control assessed in the EGEA epidemiological survey and health-related quality of life
    Valerie Siroux
    INSERM, U823, Centre de Recherche Albert Bonniot, Grenoble, France
    Respir Med 106:820-8. 2012
    ....
  22. ncbi request reprint Effects of inhaled corticosteroids on pathology in asthma and chronic obstructive pulmonary disease
    Pascal Chanez
    Clinique des Maladies Respiratoires, Hopital Arnaud de Villeneuve, 371 Avenue du Doyen Gaston Giraud, 34295 Montpellier Cedex 5, France
    Proc Am Thorac Soc 1:184-90. 2004
    ..The effects of these drugs on structural changes in COPD have not been investigated extensively. Long-term prospective studies are needed to demonstrate the potential for ICSs to affect the natural history of chronic bronchial diseases...
  23. pmc The public health implications of asthma
    Jean Bousquet
    Clinique des Maladies Respiratoires, Hopital Arnaud de Villeneuve, CHU Montpellier, 34295 Montpellier cedex 05, France
    Bull World Health Organ 83:548-54. 2005
    ..This paper presents a discussion of the burden of asthma and its socioeconomic implications and proposes a model to predict the costs incurred by the disease...
  24. ncbi request reprint Severe asthma is associated with a loss of LX4, an endogenous anti-inflammatory compound
    Isabelle Vachier
    Clinique des Maladies Respiratoires, CHU, Montpellier, France
    J Allergy Clin Immunol 115:55-60. 2005
    ..They are produced by different enzymatic pathways. Patients with severe asthma present ongoing airway inflammation despite chronic long-term treatment including oral glucocorticoids...
  25. ncbi request reprint Phenotypic determinants of uncontrolled asthma
    Valerie Siroux
    INSERM, Institut National de la Sante et de la Recherche Medicale, U823, Institut Albert Bonniot, Grenoble, France
    J Allergy Clin Immunol 124:681-7.e3. 2009
    ..Although uncontrolled asthma remains frequent, determinants of asthma control are poorly studied...
  26. doi request reprint Impact of allergic rhinitis symptoms on quality of life in primary care
    Philippe Jean Bousquet
    University Hospital, CHU de Montpellier, Montpellier, France
    Int Arch Allergy Immunol 160:393-400. 2013
    ..Allergic rhinitis (AR) impairs quality of life (QoL), sleep and work. The Allergic Rhinitis and its Impact on Asthma (ARIA) classification is widely used, but the impact of the different symptoms on QoL is not clear...
  27. pmc Associations between nitric oxide synthase genes and exhaled NO-related phenotypes according to asthma status
    Emmanuelle Bouzigon
    INSERM, U946, Paris, France
    PLoS ONE 7:e36672. 2012
    ..We investigated associations between single nucleotide polymorphisms (SNPs) of NO synthase genes (NOS) and biological NO-related phenotypes measured in two compartments (exhaled breath condensate and plasma) and blood eosinophil counts...
  28. doi request reprint Implementation of guidelines for allergic rhinitis in specialist practices. A randomized pragmatic controlled trial
    Jean Bousquet
    University Hospital and INSERM U780, Montpellier, France
    Int Arch Allergy Immunol 150:75-82. 2009
    ..Guidelines for allergic rhinitis are more effective than free-treatment choice in the control of seasonal allergic rhinitis...
  29. ncbi request reprint Immunotherapy: clinical trials--optimal trial and clinical outcomes
    Philippe Jean Bousquet
    Clinique des Maladies Respiratoires, Hopital Arnaud de Villeneuve, Centre Hospitalier Universitaire, Montpellier, France
    Curr Opin Allergy Clin Immunol 7:561-6. 2007
    ..Although specific immunotherapy was introduced a century ago, very few trials meet the criteria for pivotal studies. The paper reviews the methods which should be used to investigate specific immunotherapy...
  30. ncbi request reprint Budesonide/formoterol for maintenance and relief in uncontrolled asthma vs. high-dose salmeterol/fluticasone
    Jean Bousquet
    Hopital Arnaud de Villeneuve, 371 Avenue Doyen Gaston Giraud, FR 34000 Montpellier, France
    Respir Med 101:2437-46. 2007
    ....
  31. ncbi request reprint Exhaled nitric oxide, nitrite/nitrate levels, allergy, rhinitis and asthma in the EGEA study
    Rachel Nadif
    INSERM, U1018, CESP Centre for research in Epidemiology and Population Health, Respiratory and environmental epidemiology Team, Villejuif, France Univ Paris Sud, UMRS 1018, Villejuif, France
    Eur Respir J 44:351-60. 2014
    ..0001). Results suggest that EBC NO2 (-)/NO3 (-) and FeNO levels may be considered as biological markers of intensity of allergic sensitisation and rhinitis. ..
  32. doi request reprint Effect of smoking on symptoms of allergic rhinitis
    Philippe J Bousquet
    University Hospital and INSERM U780, Montpellier, France
    Ann Allergy Asthma Immunol 103:195-200. 2009
    ..Tobacco smoking is common in patients with allergic rhinitis...
  33. pmc Temporal asthma patterns using repeated questionnaires over 13 years in a large French cohort of women
    Margaux Sanchez
    INSERM, CESP Centre for research in Epidemiology and Population Health, U1018, Respiratory and environmental epidemiology Team, F 94807, Villejuif, France
    PLoS ONE 8:e65090. 2013
    ..The "Inconsistent" pattern is a phenotype that may capture the variable expression of asthma. Repeated answers, even to a simple question, are too often neglected...
  34. doi request reprint Communication of results and disclosure of incidental findings in longitudinal paediatric research
    Velizara Anastasova
    INSERM, UMR1027, Epidemiology and analyses in Public Health, Toulouse, France
    Pediatr Allergy Immunol 24:389-94. 2013
    ..This work analyses existing frameworks for managing such issues and proposes a policy grounded in the experience acquired in the FP7 EU project MeDALL-Mechanisms of the Development of ALLergy...
  35. ncbi request reprint Severity and impairment of allergic rhinitis in patients consulting in primary care
    Jean Bousquet
    University Hospital and Institut National de la Santé et de la Recherche Médicale U454, Montpellier, France
    J Allergy Clin Immunol 117:158-62. 2006
    ..Allergic rhinitis is a disease impairing quality of life, sleep, and work. A new classification for allergic rhinitis, Allergic Rhinitis and its Impact on Asthma (ARIA), has recently been proposed...
  36. ncbi request reprint High levels of urinary leukotriene E4 excretion in steroid treated patients with severe asthma
    Isabelle Vachier
    Clinique des Maladies Respiratoires, INSERM U454, Hopital Arnaud de Villeneuve, 371 Av du Doyen Gaston Giraud, 34295 Montpellier 5, France
    Respir Med 97:1225-9. 2003
    ..The findings support previous indications that one important component in asthmatic airway inflammation, the cysteinyl-leukotriene pathway remains relatively unopposed by oral glucocorticoids...
  37. ncbi request reprint Systemic exposure and implications for lung deposition with an extra-fine hydrofluoroalkane beclometasone dipropionate/formoterol fixed combination
    Jean Bousquet
    University of Montpellier, Montpellier, France
    Clin Pharmacokinet 48:347-58. 2009
    ....
  38. ncbi request reprint Passive and active smoking and exhaled nitric oxide levels according to asthma and atopy in adults
    Rachel Nadif
    INSERM, CESP Centre for research in Epidemiology and Population Health, Respiratory and Environmental Epidemiology Team U1018, Villejuif, France
    Ann Allergy Asthma Immunol 104:385-93. 2010
    ..No data are available regarding the utility of fractional exhaled nitric oxide (FeNO) level in guiding therapy in smoking asthmatic patients. Identification of the effect of smoking in a large sample is needed...
  39. ncbi request reprint Rapid effects of dexamethasone on intracellular pH and Na+/H+ exchanger activity in human bronchial epithelial cells
    Valia A Verrière
    INSERM U454, Centre Hospitalier Universitaire Arnaud de Villeneuve, 34295 Montpellier, France
    J Biol Chem 280:35807-14. 2005
    ....
  40. ncbi request reprint Predicting response to omalizumab, an anti-IgE antibody, in patients with allergic asthma
    Jean Bousquet
    Service de Pneumologie, Hopital Arnaud de Villeneuve, Montpellier, France
    Chest 125:1378-86. 2004
    ..To determine baseline characteristics predictive of response to omalizumab, an anti-IgE antibody, in patients with allergic asthma...
  41. ncbi request reprint Influence of sociodemographic factors on quality of life during pollen season in seasonal allergic rhinitis patients
    Laurent Laforest
    Pharmacoepidemiology Unit, EA 3091, University Hospital, Lyon, France
    Ann Allergy Asthma Immunol 95:26-32. 2005
    ..More specifically, the influence of sociodemographic factors on QOL in patients with SAR has been so far little investigated...
  42. ncbi request reprint Modulite((R)) technology in the development of formoterol HFA pMDI: clinical evidence and future opportunities
    Jean Bousquet
    , avenue du Doyen Gaston Giraud, FR 34000, Montpellier, France
    Expert Rev Respir Med 2:27-36. 2008
    ..Therefore, the Modulite formoterol hydrofluoroalkane-based formulation in extra-fine particles is a valuable therapeutic option for both patients and physicians in the management of asthma and chronic obstructive pulmonary disease...
  43. pmc Sensitisation to airborne moulds and severity of asthma: cross sectional study from European Community respiratory health survey
    Mahmoud Zureik
    European Community Respiratory Health Survey, Unit 408 Epidémiologie, Faculte de Medecine Xavier Bichat, BP 416, 75870 Paris Cedex 18, France
    BMJ 325:411-4. 2002
    ..To assess whether the severity of asthma is associated with sensitisation to airborne moulds rather than to other seasonal or perennial allergens...
  44. doi request reprint Inhaled corticosteroid/long-acting β₂-agonist combination therapy for asthma: attitudes of specialists in Europe
    Jean Bousquet
    Clinic for Respiratory Diseases, Hopital Arnaud de Villeneuve, Montpellier, France
    Int Arch Allergy Immunol 157:303-10. 2012
    ..The aim of this study was to assess which attributes of combination therapy physicians consider most important...
  45. ncbi request reprint Drug provocation tests in patients with a history suggesting an immediate drug hypersensitivity reaction
    Djamel Messaad
    Hopital Arnaud de Villeneuve, Montpellier, France
    Ann Intern Med 140:1001-6. 2004
    ..Drug hypersensitivity reactions are common and can be life-threatening. Confirmation of the diagnosis should be rigorous and based on clinical history and a physical examination, possibly followed by skin tests and drug provocation tests...
  46. ncbi request reprint [Identifying and understanding drug allergies]
    Pascal Demoly
    Inserm U 454 IFR3, Hopital Arnaud de Villeneuve, Avenue Gaston Giraud, 34295 Montpellier, France
    Med Sci (Paris) 19:327-36. 2003
    ....
  47. ncbi request reprint Natural rubber latex allergy among health care workers: a systematic review of the evidence
    Jean Bousquet
    Service des Maladies Respiratoires, INSERM U454, Hopital Arnaud de Villeneuve, University Hospital, 34295 Montpellier Cedex 5, France
    J Allergy Clin Immunol 118:447-54. 2006
    ..Natural rubber latex is a recognized allergen, but a recent meta-analysis failed to find any association between latex exposure and allergy in health care workers (HCWs)...
  48. ncbi request reprint The relation between asthma and allergic rhinitis
    Pascal Demoly
    Exploration des Allergies Maladies Respiratoires INSERM U454, Hopital Arnaud de Villeneuve, University Hospital of Montpellier, 34295 Montpellier Cedex 5, France
    Lancet 368:711-3. 2006
  49. ncbi request reprint Primary and secondary prevention of allergy and asthma by allergen therapeutic vaccines
    Jean Bousquet
    Montpellier University, Montpellier, France
    Clin Allergy Immunol 18:105-14. 2004
  50. ncbi request reprint Epidemiologic study of the genetics and environment of asthma, bronchial hyperresponsiveness, and atopy
    Francine Kauffmann
    Epidemiology and Biostatistics, Institut National de la Santé et de la Recherche Médicale INSERM U472, Villejuif, France
    Chest 121:27S. 2002
  51. ncbi request reprint Allergen immunotherapy: therapeutic vaccines for asthma
    Jean Bousquet
    Montpellier University, Montpellier, France
    Clin Allergy Immunol 18:511-28. 2004
  52. ncbi request reprint Allergic rhinitis: a disease remodeling the upper airways?
    Jean Bousquet
    Clinique des Maladies Respiratoires, University Hospital and INSERM U454, Montpellier, France
    J Allergy Clin Immunol 113:43-9. 2004
    ..A better understanding of nasal and bronchial remodeling might help to identify new pathways and new therapeutic strategies to reduce long-term remodeling in asthma...
  53. ncbi request reprint Lipoxins are potential endogenous antiinflammatory mediators in asthma
    Caroline Bonnans
    Clinique des Maladies Respiratoires, INSERM U454 IFR 3, CHU, Montpellier, France
    Am J Respir Crit Care Med 165:1531-5. 2002
    ..Moreover, pertussis toxin reversed LXA4- and LXB4-inhibited IL-8 release. These findings suggest that lipoxins have potential antiinflammatory action in asthma...
  54. ncbi request reprint Overexpression of the human glucocorticoid receptor alpha and beta isoforms inhibits AP-1 and NF-kappaB activities hormone independently
    Claire Gougat
    Institut National de la Santé et de la Recherche Médicale U454 IFR3 and Service des Maladies Respiratoires, CHU de Montpellier, 34295 Montpellier Cedex 5, France
    J Mol Med (Berl) 80:309-18. 2002
    ..This property was not shared by the closely related mineralocorticoid receptor. Our results suggest that overexpression of either GRalpha or GRbeta may have an anti-inflammatory effect...
  55. ncbi request reprint A meta-analysis of the dose-response relationship of inhaled corticosteroids in adolescents and adults with mild to moderate persistent asthma
    Jean Bousquet
    Service des Maladies Respiratoires, Hopital Arnaud de Villeneuve, Centre Hospitalier Universitaire Montpellier, France
    Clin Ther 24:1-20. 2002
    ..Although inhaled corticosteroids (ICS) are commonly used in the treatment of persistent asthma, the relationship between dose and clinical response remains unclear...
  56. ncbi request reprint Allergies and parasitoses in sub-Saharan Africa
    Mor Ndiaye
    Service des Maladies Respiratoires, Hopital Arnaud de Villeneuve, Montpellier, France
    Clin Rev Allergy Immunol 26:105-13. 2004
    ..The data is particularly applicable to Senegal but can be extrapolated to other regions throughout the world and the results have implications for the induction of allergic disease in both western and Third World countries...
  57. doi request reprint Rhinitis and onset of asthma: a longitudinal population-based study
    Rafea Shaaban
    Unit 700 Epidemiology, National Institute of Health and Medical Research INSERM, Paris, France
    Lancet 372:1049-57. 2008
    ..We used the follow-up data from the European Community Respiratory Health Survey to investigate the onset of asthma in patients with allergic and non-allergic rhinitis during an 8.8-year period...
  58. ncbi request reprint Inhaled corticosteroids effects on bone in asthmatic and COPD patients: a quantitative systematic review
    Florent Richy
    WHO Collaborating Center for Public Health Aspects of Osteoarticular Disorders, Liege, Belgium
    Osteoporos Int 14:179-90. 2003
    ..These findings could have practical implication in the long-term management of asthmatic and COPD patients...
  59. ncbi request reprint Association between asthma and rhinitis according to atopic sensitization in a population-based study
    Benedicte Leynaert
    INSERM Unité 408, Paris, France
    J Allergy Clin Immunol 113:86-93. 2004
    ..Although asthma and rhinitis often occur together, the reason for this common comorbidity is still a matter of debate...
  60. ncbi request reprint Can guideline-defined asthma control be achieved? The Gaining Optimal Asthma ControL study
    Eric D Bateman
    UCT Lung Institute, P O Box 34560, Groote Schuur 7937, Cape Town, South Africa
    Am J Respir Crit Care Med 170:836-44. 2004
    ..07-0.27 per patient per year) and improvement in health status were significantly better with salmeterol/fluticasone. This study confirms that the goal of guideline-derived asthma control was achieved in a majority of the patients...
  61. ncbi request reprint Written information plans for patients receiving immunotherapy
    Jean Bousquet
    Ann Allergy Asthma Immunol 91:423-4. 2003
  62. ncbi request reprint Allergic rhinitis and its consequences on quality of sleep: An unexplored area
    Damien Leger
    Centre du Sommeil et de la Vigilance de l Hôtel Dieu, Assistance Publique Hopitaux de Paris, Paris, France
    Arch Intern Med 166:1744-8. 2006
    ..The objective of our study was to assess, in patients with AR, whether duration and severity of AR are associated with sleep impairment...
  63. ncbi request reprint Allergic rhinitis, rhinosinusitis, and asthma: one airway disease
    Claus Bachert
    ENT Department, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    Immunol Allergy Clin North Am 24:19-43. 2004
  64. ncbi request reprint The anti-inflammatory effects of omalizumab confirm the central role of IgE in allergic inflammation
    Stephen Holgate
    RCMB Research Division, Southampton General Hospital, United Kingdom
    J Allergy Clin Immunol 115:459-65. 2005
    ....
  65. ncbi request reprint Quality of life during pollen season in patients with seasonal allergic rhinitis with or without asthma
    Laurent Laforest
    Pharmacoepidemiology Unit, EA3091 CHU Lyon Sud, Pierre Benite, France
    Int Arch Allergy Immunol 136:281-6. 2005
    ..Generic QOL between groups was also compared at pollen peak...
  66. ncbi request reprint Meta-analysis: effects of adding salmeterol to inhaled corticosteroids on serious asthma-related events
    Eric Bateman
    Division of Pulmonology, Department of Medicine, University of Cape Town, Cape Town, South Africa
    Ann Intern Med 149:33-42. 2008
    ..Recent analyses have suggested an increased risk for serious asthma-related adverse events in patients receiving long-acting beta-agonists...
  67. ncbi request reprint [Nasal allergy and asthma: one or two diseases?]
    Pascal Demoly
    Maladies Respiratoires, INSERM U454, IFR3, Hopital Arnaud de Villeneuve, CHU de Montpellier, 34295 Montpellier cedex 05
    Bull Acad Natl Med 189:1461-73. 2005
    ....
  68. ncbi request reprint Improvement of aspirin-intolerant asthma by montelukast, a leukotriene antagonist: a randomized, double-blind, placebo-controlled trial
    Sven Erik Dahlen
    Experimental Asthma and Allergy Research, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Am J Respir Crit Care Med 165:9-14. 2002
    ..Addition of a leukotriene receptor antagonist such as montelukast improves asthma in aspirin-intolerant patients over and above what can be achieved by glucocorticosteroids...
  69. ncbi request reprint Clinical and biological heterogeneity in children with moderate asthma
    Stefania La Grutta
    Istituto di Medicina Generale e Pneumologia, Universita di Palermo, Via Trabucco 180, 90146 Palermo, Italy
    Am J Respir Crit Care Med 167:1490-5. 2003
    ....
  70. ncbi request reprint Identifying 'well-controlled' and 'not well-controlled' asthma using the Asthma Control Questionnaire
    Elizabeth F Juniper
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada
    Respir Med 100:616-21. 2006
    ....
  71. ncbi request reprint Positioning of glucocorticosteroids in asthma and allergic rhinitis guidelines (versus other therapies)
    Guy F Joos
    Department of Respiratory Diseases, Ghent University Hospital, De Pintelaan 185, B 9000 Ghent, Belgium
    Immunol Allergy Clin North Am 25:597-612, vii-viii. 2005
    ..Intranasal corticosteroids are given as first-line therapy for moderate to severe persistent rhinitis. Depending on the dominant symptom, H1-antihistamines, decongestants, or ipratropium can be added after re-evaluation...
  72. ncbi request reprint Influence of patients' characteristics and disease management on asthma control
    Laurent Laforest
    Pharmacoepidemiology Unit, EA3091, Lyon, France
    J Allergy Clin Immunol 117:1404-10. 2006
    ..Although asthma control is a major outcome in disease management, little is known about its determinants...
  73. ncbi request reprint ARIA update: I--Systematic review of complementary and alternative medicine for rhinitis and asthma
    Giovanni Passalacqua
    Allergy and Respiratory Diseases, University of Genoa, Italy
    J Allergy Clin Immunol 117:1054-62. 2006
    ..There are also unresolved safety concerns. Therapeutic efficacy of complementary-alternative treatments for rhinitis and asthma is not supported by currently available evidence...
  74. ncbi request reprint Persistent activation of nuclear factor-kappaB signaling pathway in severe uncontrolled asthma
    Rosalia Gagliardo
    Istituto di Biomedicina e Immunologia Molecolare, Consiglio Nazionale delle Ricerche, Palermo, Via Ugo La Malfa 153, 90146 Palermo, Italy
    Am J Respir Crit Care Med 168:1190-8. 2003
    ..Our data suggest that exaggerated NF-kappaB activation perpetuates inflammatory mediators production in severe asthma...
  75. ncbi request reprint Noninvasive methods for the detection of upper and lower airway inflammation in atopic children
    Mirella Profita
    Institute of Biomedicine and Molecular Immunology, Section of Immunopathology and Clinical and Experimental Pharmacology of the Respiratory System, Italian National Research Council, Palermo, Italy
    J Allergy Clin Immunol 118:1068-74. 2006
    ..Exhaled nitric oxide (FE(NO)) and exhaled breath condensate (EBC) are noninvasive methods to assess inflammation...
  76. ncbi request reprint Clustering patterns of LOD scores for asthma-related phenotypes revealed by a genome-wide screen in 295 French EGEA families
    Emmanuelle Bouzigon
    1INSERM EMI0006, Evry, France
    Hum Mol Genet 13:3103-13. 2004
    ..These results provide new insights into the potential sharing of genetic determinants by asthma-related phenotypes...
  77. ncbi request reprint Levocetirizine improves quality of life and reduces costs in long-term management of persistent allergic rhinitis
    Claus Bachert
    Department of Oto Rhino Laryngology, University Hospital, Ghent, Belgium
    J Allergy Clin Immunol 114:838-44. 2004
    ..The Xyzal in Persistent Rhinitis Trial is the first large, long-term clinical trial studying patients with persistent rhinitis as defined by Allergic Rhinitis and its Impact on Asthma...
  78. pmc Montelukast and fluticasone compared with salmeterol and fluticasone in protecting against asthma exacerbation in adults: one year, double blind, randomised, comparative trial
    Leif Bjermer
    Department of Respiratory Medicine and Allergology, University Hospital, SE 221 85 Lund, Sweden
    BMJ 327:891. 2003
    ..Design and setting A 52 week, two period, double blind, multicentre trial during which patients whose symptoms remained uncontrolled by inhaled corticosteroids were randomised to add montelukast or salmeterol...
  79. ncbi request reprint Synergistic effects of fluticasone propionate and salmeterol on in vitro T-cell activation and apoptosis in asthma
    Elisabetta Pace
    Istituto di Biomedicina e Immunologia Molecolare, Consiglio Nazionale delle Richerche, Via Ugo La Malfa 153, 90146 Palermo, Italy
    J Allergy Clin Immunol 114:1216-23. 2004
    ..In asthma T cells are characterized by an increased activation state and by reduced apoptosis...
  80. ncbi request reprint How appropriate is asthma therapy in general practice?
    Laurent Laforest
    Pharmacoepidemiology Unit, EA 3091, CHU Lyon, France
    Fundam Clin Pharmacol 19:107-15. 2005
    ..Antibiotics, expectorants, antihistamines, antitussives and nasal corticosteroids were commonly prescribed while asthma controllers were under-used...
  81. ncbi request reprint Rate of response of individual asthma control measures varies and may overestimate asthma control: an analysis of the goal study
    Eric D Bateman
    University of Cape Town, Cape Town, South Africa
    J Asthma 44:667-73. 2007
    ....
  82. pmc Evidence for linkage of a new region (11p14) to eczema and allergic diseases
    Michel Guilloud-Bataille
    INSERM U535, Hopital Paul Brousse, Bâtiment Leriche, B P 1000, 94817, Villejuif Cedex, France
    Hum Genet 122:605-14. 2008
    ..Further investigations in this region will allow identifying genetic factor(s) which could have pleiotropic effect in the three allergic diseases...
  83. ncbi request reprint Determinants of response to fluticasone propionate and salmeterol/fluticasone propionate combination in the Gaining Optimal Asthma controL study
    Søren E Pedersen
    Department of Pediatrics, University of Southern Denmark, Pediatric Research Unit, Kolding Hospital, Kolding, Denmark
    J Allergy Clin Immunol 120:1036-42. 2007
    ..Approximately two thirds of patients achieved well-controlled (WC) asthma, and one third continued to have asthma that was not well controlled (NWC)...
  84. ncbi request reprint [Allergic rhinitis and its impact on asthma update (ARIA 2008). The Turkish perspective]
    Arzu Yorgancioglu
    Department of Chest Diseases, Faculty of Medicine, Celal Bayar University, Manisa, Turkey
    Tuberk Toraks 56:224-31. 2008
    ..In this article, it is aimed to summarize the newly updated and published version of "Allergic Rhinitis and its Impact on Asthma (ARIA) 2008" and add the recent Turkish epidemiological data on it...
  85. ncbi request reprint Levocetirizine improves health-related quality of life and health status in persistent allergic rhinitis
    G Walter Canonica
    Allergy and Respiratory Diseases Clinic, DIMI, Genoa University, Pad Maragliano, L go R Benzi 10, 16132 Genoa, Italy
    Respir Med 100:1706-15. 2006
    ..Allergic rhinitis is a chronic respiratory disorder with a detrimental impact on health-related quality of life (HRQOL) and health status. Enhancement and maintenance of patient function and well-being are therefore considered as essential...
  86. ncbi request reprint Improvement in asthma endpoints when aiming for total control: salmeterol/fluticasone propionate versus fluticasone propionate alone
    Ashley A Woodcock
    North West Lung Centre, Wythenshawe Hospital, Manchester, UK
    Prim Care Respir J 16:155-61. 2007
    ..To investigate the magnitude of change in morning peak expiratory flow (PEF), asthma symptoms, and rescue beta2-agonist use, when the aim of treatment is to achieve guideline-defined control...
  87. ncbi request reprint Selective immediate hypersensitivity to clavulanic acid
    Nadia Raison-Peyron
    Ann Pharmacother 37:1146-7. 2003