M Bourin

Summary

Country: France

Publications

  1. ncbi request reprint Cyamemazine as an anxiolytic drug on the elevated plus maze and light/dark paradigm in mice
    M Bourin
    EA Neurobiologie de l Anxiété et de la Dépression, Faculte de Medecine, BP 53508, 44035 Nantes cedex 1, France
    Behav Brain Res 124:87-95. 2001
  2. ncbi request reprint Antidepressant-like effects in various mice strains in the forced swimming test
    Denis Joseph Paul David
    EA 3256 Neurobiologie de l Anxiété et de la Dépression, Faculte de Medecine, 1 rue Gaston Veil, BP 53508, 44035, Nantes Cedex 01, France
    Psychopharmacology (Berl) 166:373-82. 2003
  3. ncbi request reprint Does rat global transient cerebral ischemia serve as an appropriate model to study emotional disturbances?
    Guy Bernard Bantsiele
    Laboratoire de Pharmacologie, Faculte de Medecine, Universite de Rennes 1, CS34317, 35043 Rennes, France
    Fundam Clin Pharmacol 18:685-92. 2004
  4. ncbi request reprint [Pharmacology of antipsychotic drugs]]
    M Bourin
    Universite de Nantes, EA 3256 Neurobiologie de l Anxiété et de la Dépression, 1, rue Gaston Veil, BP 53508, 44035 Nantes
    Encephale 32:S8-9. 2006
  5. ncbi request reprint [Sleep and wakefulness drugs and their indications]
    M Bourin
    EA 3256 Neurobiologie de l Anxiété et de la Dépression, Faculte de Medecine, BP 53508, F 44035 Nantes Cedex 1
    Ann Pharm Fr 65:251-7. 2007
  6. pmc How assess drugs in the treatment of acute bipolar mania?
    Michel Bourin
    Neurobiologie de l anxiété et de la dépression, Faculte de Medecine, Université de Nantes Nantes, France
    Front Pharmacol 4:4. 2013
  7. ncbi request reprint Topiramate and phenytoin anti-immobility effect in the mice forced swimming test is reversed by veratrine: Implication for bipolar depression treatment
    Michel Bourin
    EA 3256 Neurobiologie de l Anxiété et de la Dépression, Faculte de Medecine, BP 53508, 1 rue Gaston Veil, F44035 Nantes Cedex 01, France
    Behav Brain Res 205:421-5. 2009
  8. ncbi request reprint The role of mood stabilisers in the treatment of the depressive facet of bipolar disorders
    Michel Bourin
    EA 3256 Neurobiologie de l Anxiété et de la Dépression, Faculté de Médecine 1, rue Gaston Veil BP 53508, 44035 Nantes Cedex 01, France
    Neurosci Biobehav Rev 31:963-75. 2007
  9. ncbi request reprint Anxiolytic-like effect of milnacipran in the four-plate test in mice: mechanism of action
    Michel Bourin
    EA 3256 Neurobiologie de l anxiété et de la dépression Faculté de Médecine BP 53508, 1, rue Gaston Veil, 44035 Nantes Cedex 01, France
    Pharmacol Biochem Behav 81:645-56. 2005
  10. doi request reprint Augmentation effect of combination therapy of aripiprazole and antidepressants on forced swimming test in mice
    Michel Bourin
    EA 3256 Neurobiologie de l Anxiété et de la Dépression, Faculté de Médecine 1, rue Gaston Veil, BP 53508, 44035, Nantes Cedex 01, France
    Psychopharmacology (Berl) 206:97-107. 2009

Collaborators

Detail Information

Publications96

  1. ncbi request reprint Cyamemazine as an anxiolytic drug on the elevated plus maze and light/dark paradigm in mice
    M Bourin
    EA Neurobiologie de l Anxiété et de la Dépression, Faculte de Medecine, BP 53508, 44035 Nantes cedex 1, France
    Behav Brain Res 124:87-95. 2001
    ..The discrepancy of results obtained in the tests, following acute or chronic administration could be the result of the combined activity of dopamine D(2) receptor antagonism with antagonism of 5-HT(2C) and 5-HT(3) receptors...
  2. ncbi request reprint Antidepressant-like effects in various mice strains in the forced swimming test
    Denis Joseph Paul David
    EA 3256 Neurobiologie de l Anxiété et de la Dépression, Faculte de Medecine, 1 rue Gaston Veil, BP 53508, 44035, Nantes Cedex 01, France
    Psychopharmacology (Berl) 166:373-82. 2003
    ..Strain differences in mice have been reported in response to drugs in the mouse forced swimming test (FST), even if few antidepressants were examined...
  3. ncbi request reprint Does rat global transient cerebral ischemia serve as an appropriate model to study emotional disturbances?
    Guy Bernard Bantsiele
    Laboratoire de Pharmacologie, Faculte de Medecine, Universite de Rennes 1, CS34317, 35043 Rennes, France
    Fundam Clin Pharmacol 18:685-92. 2004
    ....
  4. ncbi request reprint [Pharmacology of antipsychotic drugs]]
    M Bourin
    Universite de Nantes, EA 3256 Neurobiologie de l Anxiété et de la Dépression, 1, rue Gaston Veil, BP 53508, 44035 Nantes
    Encephale 32:S8-9. 2006
  5. ncbi request reprint [Sleep and wakefulness drugs and their indications]
    M Bourin
    EA 3256 Neurobiologie de l Anxiété et de la Dépression, Faculte de Medecine, BP 53508, F 44035 Nantes Cedex 1
    Ann Pharm Fr 65:251-7. 2007
    ..Narcolepsy, which is characterized by daytime sleepiness and irresistible episodes of sleep, is treated by an alpha1 noradrenergic stimulant modafinil which has no amphetaminic properties...
  6. pmc How assess drugs in the treatment of acute bipolar mania?
    Michel Bourin
    Neurobiologie de l anxiété et de la dépression, Faculte de Medecine, Université de Nantes Nantes, France
    Front Pharmacol 4:4. 2013
    ....
  7. ncbi request reprint Topiramate and phenytoin anti-immobility effect in the mice forced swimming test is reversed by veratrine: Implication for bipolar depression treatment
    Michel Bourin
    EA 3256 Neurobiologie de l Anxiété et de la Dépression, Faculte de Medecine, BP 53508, 1 rue Gaston Veil, F44035 Nantes Cedex 01, France
    Behav Brain Res 205:421-5. 2009
    ..The fact that most of the anticonvulsants used in the treatment of bipolar disorders are blockers of voltage-gated Na channels has determined our interest in evaluating the role of ion channels in bipolar disorders...
  8. ncbi request reprint The role of mood stabilisers in the treatment of the depressive facet of bipolar disorders
    Michel Bourin
    EA 3256 Neurobiologie de l Anxiété et de la Dépression, Faculté de Médecine 1, rue Gaston Veil BP 53508, 44035 Nantes Cedex 01, France
    Neurosci Biobehav Rev 31:963-75. 2007
    ....
  9. ncbi request reprint Anxiolytic-like effect of milnacipran in the four-plate test in mice: mechanism of action
    Michel Bourin
    EA 3256 Neurobiologie de l anxiété et de la dépression Faculté de Médecine BP 53508, 1, rue Gaston Veil, 44035 Nantes Cedex 01, France
    Pharmacol Biochem Behav 81:645-56. 2005
    ..The present data suggest a strong connection between 5-HT2A receptors and NA neurotransmission...
  10. doi request reprint Augmentation effect of combination therapy of aripiprazole and antidepressants on forced swimming test in mice
    Michel Bourin
    EA 3256 Neurobiologie de l Anxiété et de la Dépression, Faculté de Médecine 1, rue Gaston Veil, BP 53508, 44035, Nantes Cedex 01, France
    Psychopharmacology (Berl) 206:97-107. 2009
    ..We hypothesized that aripiprazole, a partial D(2) agonist, could increase the activity of various antidepressants in the mice forced swimming test (FST), an animal model of depression...
  11. doi request reprint [The problems with the use of benzodiazepines in elderly patients]
    M Bourin
    EA 3256 Neurobiologie de l Anxiété et de la Dépression, Faculte de Medecine, Universite de Nantes, 1 rue Gaston Veil, BP 53508, 44035 Nantes Cedex 01, France
    Encephale 36:340-7. 2010
    ..e. essentially BZD that are not metabolised in the strictest sense of the term, such as lorazepam or temazepam. Daily doses must be extremely limited and duration of use should not exceed two or three months in young patients...
  12. ncbi request reprint Animal models of anxiety in mice
    Michel Bourin
    EA 3256 Neurobiologie de l anxiété et de la dépression Faculté de Médecine 1, rue Gaston Veil, BP 53508, 44035 Nantes Cedex 01, France
    Fundam Clin Pharmacol 21:567-74. 2007
    ..Finally, we focused on the consequences of re-exposure to the apparatus. Test-retest procedures can bring in new answers, but should be deeply studied, to revalidate the whole paradigm as an animal model of anxiety...
  13. ncbi request reprint A proposal of decision tree to screen putative antidepressants using forced swim and tail suspension tests
    Michel Bourin
    EA 3256 Neurobiologie de l Anxiété et de la Dépression, Faculte de Medecine, BP 53508, 1 rue Gaston Veil, F44035 Nantes Cedex 01, France
    Behav Brain Res 164:266-9. 2005
    ..Detection of an antidepressant-like activity could be performed using only one test (TST with Swiss mice or FST with Swiss and C57Bl/6 Rj mice), but both tests are necessary to conclude on the mechanism of action...
  14. doi request reprint Implication of 5-HT2 receptor subtypes in the mechanism of action of the GABAergic compound etifoxine in the four-plate test in Swiss mice
    Michel Bourin
    Neurobiologie de l anxiété et de la dépression, Faculte de Medecine, Nantes, France
    Behav Brain Res 208:352-8. 2010
    ..Etifoxine has been shown to possess some anxiolytic-like effects in rodents...
  15. pmc Evidence for the activity of lamotrigine at 5-HT(1A) receptors in the mouse forced swimming test
    Michel Bourin
    Neurobiologie de l anxiété et de la dépression, Faculte de Medecine, Nantes, France
    J Psychiatry Neurosci 30:275-82. 2005
    ..Association studies using specific and nonspecific ligands acting on serotonin (5-hydroxytryptamine; 5-HT1) receptor subtypes were undertaken to evaluate the potential role of these receptors in the anti-immobility effect of lamotrigine...
  16. ncbi request reprint The role of sodium channels in the mechanism of action of antidepressants and mood stabilizers
    Michel Bourin
    Faculté de Médecine 1, rue Gaston Veil BP 53508 44035 Nantes cedex 01, France
    Curr Drug Targets 10:1052-60. 2009
    ..Authors conclude that the development of new drugs acting on sodium channels could potentially be of interest as antidepressants, but also as augmentation strategies for classical antidepressants...
  17. ncbi request reprint Melatonin receptor agonist agomelatine: a new drug for treating unipolar depression
    Michel Bourin
    EA 3256 Neurobiologie de l Anxiété et de la Dépression, Faculte de Medecine, Universite de Nantes, France
    Curr Pharm Des 15:1675-82. 2009
    ..It will be of interest to see if agomelatine expands the spectrum of treatment for unipolar depression. It shows efficacy in acute phase and in of maintenance treatment compared to reference antidepressants as paroxetine and venlafaxine...
  18. ncbi request reprint Antidepressant-like activity of selective serotonin reuptake inhibitors combined with a NK1 receptor antagonist in the mouse forced swimming test
    F Chenu
    Laboratoire de Pharmacologie de l anxiété et de la dépression EA3256, Faculte de Medecine, 1 rue Gaston Veil, 44035 Nantes Cedex, France
    Behav Brain Res 172:256-63. 2006
    ....
  19. ncbi request reprint Light/dark cycle manipulation influences mice behaviour in the elevated plus maze
    Florence Clénet
    EA 3256 Neurobiologie de l Anxiété et de la Dépression, Faculte de Medecine, BP 53508, 1 rue Gaston Veil, 44035 Nantes Cedex 01, France
    Behav Brain Res 166:140-9. 2006
    ..Moreover, the light conditions imposed on mice before the test may be an important factor in the variability of the response to serotonergic but not to benzodiazepine treatments...
  20. ncbi request reprint Anxiolytic-like effects of 5-HT2 ligands on three mouse models of anxiety
    Brid Aine Nic Dhonnchadha
    EA 3256 Neurobiologie de l Anxiété et de la Dépression, Laboratoire Pharmacologie et GIS Medicament, Faculté Médecien et GIS Medicament, BP 53508, 1 rue Gaston Veil, F44035 Nantes, Cedex 01, France
    Behav Brain Res 140:203-14. 2003
    ....
  21. ncbi request reprint Involvement of 5-HT(2C) receptors in the anti-immobility effects of antidepressants in the forced swimming test in mice
    F Clenet
    , , , BP 53508, 1 rue Gaston Veil, F44035 Cedex 01, Nantes, France
    Eur Neuropsychopharmacol 11:145-52. 2001
    ..There is evidence that 5-HT(2C) receptors may be involved in the action of antidepressants which are able to boost the concentration of serotonin in the synapse, i.e. SSRIs and imipramine..
  22. ncbi request reprint Effect of noradrenergic system on the anxiolytic-like effect of DOI (5-HT2A/2C agonists) in the four-plate test
    Fabienne Masse
    EA 3256, Neurobiologie de l anxiété et de la dépression, Faculte de Medecine, BP 53508, 1 rue Gaston Veil, 44035, Nantes Cedex 01, France
    Psychopharmacology (Berl) 183:471-81. 2006
    ..On the other hand, the alpha-adrenergic ligands have also demonstrated an activity in other models of anxiety. A previous study demonstrated that the alpha2-adrenoceptor agonists abolished the anxiolytic-like effect of antidepressants...
  23. doi request reprint Antidepressant-like effect of lamotrigine is reversed by veratrine: a possible role of sodium channels in bipolar depression
    Corina Prica
    EA 3256 Neurobiologie de l Anxiété et de la Dépression, Faculte de Medecine, 1 rue Gaston Veil, BP 53508, 44035 Nantes Cedex 01, France
    Behav Brain Res 191:49-54. 2008
    ..It is thought to act by inhibition of glutamate release through blockade of voltage-sensitivity sodium channels and stabilization of the neuronal membrane...
  24. ncbi request reprint alpha2-Adrenergic agonists antagonise the anxiolytic-like effect of antidepressants in the four-plate test in mice
    Fabienne Masse
    Neurobiology of Anxiety and Depression, Faculty of Medicine, Nantes, France
    Behav Brain Res 164:17-28. 2005
    ....
  25. ncbi request reprint Is dopamine implicated in the antidepressant-like effects of selective serotonin reuptake inhibitors in the mouse forced swimming test?
    C E Renard
    EA Neurobiologie de l Anxiété et de la Dépression, Faculte de Medecine, BP 53508, 1 rue Gaston Veil, 44035 Nantes Cedex 01, France
    Psychopharmacology (Berl) 159:42-50. 2001
    ..Microdialysis, binding and behavioural studies have shown that the dopaminergic system plays a role in antidepressant treatment...
  26. ncbi request reprint The four-plates test-retest paradigm to discriminate anxiolytic effects
    Nadège Ripoll
    Neurobiologie de l anxiété et de la dépression, Faculte de Medecine, EA 3256, 1 rue Gaston Veil, BP 53508, 44035 Nantes Cedex 01, France
    Psychopharmacology (Berl) 180:73-83. 2005
    ..Retesting mice in animal models of anxiety markedly alters the behavioural profile of various drugs...
  27. ncbi request reprint Evidence for a 5-HT2A receptor mode of action in the anxiolytic-like properties of DOI in mice
    Brid Aine Nic Dhonnchadha
    EA 3256 Neurobiologie de l Anxiété et de la Dépression, Faculte de Medecine, BP53508, 1 rue Gaston Veil, 44035 Nantes, France
    Behav Brain Res 147:175-84. 2003
    ..1 and 1 mg/kg, i.p. 45 min pre-test) nor SB 206553 (0.1 and 1 mg/kg, i.p. 45 min pre-test). In conclusion, DOI produced an anxiolytic-like profile in the mouse FPT and EPM. These effects are likely to be 5-HT2A receptor mediated...
  28. doi request reprint Is co-administration of bupropion with SSRIs and SNRIs in forced swimming test in mice, predictive of efficacy in resistant depression?
    Corina Prica
    EA 3256 Neurobiologie de l Anxiété et de la Dépression, Faculté de Médecine 1, rue Gaston Veil BP 53508, 44035 Nantes Cedex 01, France
    Behav Brain Res 194:92-9. 2008
    ..The animal models of depression also suggest an implication of dopamine in the physiopathology of depression. The forced swimming test is an animal model used to predict the antidepressant activity of drugs...
  29. ncbi request reprint Implication of 5-HT2 receptor subtypes in the mechanism of action of antidepressants in the four plates test
    Brid Aine Nic Dhonnchadha
    EA 3256, Neurobiologie de l anxiété et de la dépression, Faculte de Medecine, BP 53508, 1 rue Gaston Veil, 44035 Nantes Cedex 01, France
    Psychopharmacology (Berl) 179:418-29. 2005
    ..However, it is not yet known which 5-HT receptor subtypes mediate the therapeutic effects of antidepressants...
  30. ncbi request reprint Anxiolytic-like effect of 5-HT(2) ligands and benzodiazepines co-administration: comparison of two animal models of anxiety (the four-plate test and the elevated plus maze)
    Fabienne Masse
    EA 3256 Neurobiologie de l Anxiété et de la Dépression, Faculte de Medecine, BP 53508, 1 rue Gaston Veil, F44035 Nantes Cedex 01, France
    Behav Brain Res 177:214-26. 2007
    ..Regardless of anxiety models used in this study, 5-HT(2A) ligands exerted facilitatory influence upon GABAergic system. Therefore, the FPT and the EPM might implicate the same kind of anxiety...
  31. ncbi request reprint Implication of 5-HT2A subtype receptors in DOI activity in the four-plates test-retest paradigm in mice
    Nadège Ripoll
    Research Group, EA 3256, Neurobiologie de l anxiété et de la dépression, Faculte de Medecine, BP 53508, 1 rue Gaston Veil, F44035 Nantes Cedex 01, France
    Behav Brain Res 166:131-9. 2006
    ..Our findings altogether also suggest that DOI exerts its anxiolytic-like effect in the FPT test-retest paradigm through 5-HT(2A) receptors...
  32. pmc Serotonin1B heteroreceptor activation induces an antidepressant-like effect in mice with an alteration of the serotonergic system
    Franck Chenu
    Neurobiologie de l anxiété et de la dépression, Faculte de Medecine, Universite de Nantes, Nantes, France
    J Psychiatry Neurosci 33:541-50. 2008
    ..We sought to demonstrate whether the specific activation of serotonin1B (5-HT1B) heteroreceptors by systemic or local administration of the selective 5-HT1B receptor agonist anpirtoline could mediate antidepressant-like effects in mice...
  33. ncbi request reprint The mouse light-dark paradigm: a review
    M Hascoet
    Faculty of Medicine, JE 2029 Neurobiologie de l anxiété, Faculty de Medecine, Nantes, France
    Prog Neuropsychopharmacol Biol Psychiatry 25:141-66. 2001
    ..g. serotonergic drugs) can be detected using this paradigm. It has the advantages of being quick and easy to use, without requiring the prior training of animals...
  34. ncbi request reprint A 2-amino-2-oxazoline derivative as an antidepressant in mice
    M Bourin
    Laboratoire de Pharmacologie, Faculte de Medecine, Nantes, France
    Arzneimittelforschung 38:666-8. 1988
    ..It had no monoamine oxidase inhibitory activity. These results suggest a profile close to that of viloxazine and to that of a classic antidepressant...
  35. ncbi request reprint Role of dopaminergic and serotonergic systems on behavioral stimulatory effects of low-dose alprazolam and lorazepam
    D Bentue-Ferrer
    Laboratoire de Pharmacologie Experimentale et Clinique, Faculte de Medecine, 2 Avenue du Pr Leon Bernard, 35043 Rennes Cedex, France
    Eur Neuropsychopharmacol 11:41-50. 2001
    ..This effect could be explained, at least in part, by increased extracellular dopamine concentrations in the striatum. Their different structures could explain the different pattern observed for the two benzodiazepines...
  36. doi request reprint Brain structures implicated in the four-plate test in naïve and experienced Swiss mice using injection of diazepam and the 5-HT2A agonist DOI
    Benoit Petit-Demouliere
    EA 3256 Neurobiologie de l Anxiété et de la Dépression, Faculte de Medecine, BP 53508, 1 rue Gaston Veil, F44035, Nantes Cedex 01, France
    Behav Brain Res 204:200-5. 2009
    ..These results help us to better understand the way of action of these two compounds and the structures functionally involved in their effects and in one-trial tolerance (OTT)...
  37. ncbi request reprint Antidepressant-like effects in various mice strains in the tail suspension test
    Nadège Ripoll
    Faculte de Medecine, EA 3256 Neurobiologie de l Anxiété et de la Dépression, BP 53508, 1 rue Gaston Veil, F44035 Nantes, Cedex 01, France
    Behav Brain Res 143:193-200. 2003
    ..Our results suggest that response to an antidepressant treatment is under control of genetic factors and that the strain of mouse is an important parameter to consider...
  38. ncbi request reprint Comparison of antidepressant activity in 4- and 40-week-old male mice in the forced swimming test: involvement of 5-HT1A and 5-HT1B receptors in old mice
    D J David
    , , Nantes, France
    Psychopharmacology (Berl) 153:443-9. 2001
    ..Our results suggested that 5-HT1B receptors may be more altered than 5-HT1A receptors in 40-week-old mice...
  39. ncbi request reprint Is iprindole an indirect betamimetic drug?
    H Ganry
    Laboratoire de Pharmacologie, Faculte de Medecine, Nantes, France
    Neuropsychobiology 20:187-93. 1988
    ..Beta 2-adrenergic agonists and antagonists specifically modify the effect of iprindole on spontaneous motility. These results indicate that iprindole has an indirect beta 2-mimetic effect...
  40. ncbi request reprint Factors triggering abolishment of benzodiazepines effects in the Four-Plate Test--retest in mice
    B Petit-Demouliere
    EA 3256 Neurobiologie de l Anxiété et de la Dépression, Faculte de Medecine, BP 53508, 1 rue Gaston Veil, F44035 Nantes Cedex 01 France
    Eur Neuropsychopharmacol 18:41-7. 2008
    ..Electric punishments do not trigger OTT to benzodiazepines; whilst knowledge of the environment seems to be responsible for this phenomenon. FPT may be useful to study OTT because punishments potentate OTT in this model of anxiety...
  41. ncbi request reprint Potentiation of antidepressant-like activity with lithium: mechanism involved
    Franck Chenu
    Neurobiologie de l anxiété et de la dépression, EA 3256, Faculte de Medecine, 1 rue Gaston Veil, 44035 Nantes Cedex, France
    Curr Drug Targets 7:159-63. 2006
    ..We also suggested that the anti-manic effect of lithium was linked to this activity on 5-HT1B receptors, occurring this time on 5-HT1B postsynaptic (heteroreceptors on dopaminergic pathways) receptors levels...
  42. ncbi request reprint Effect of GABAergic ligands on the anxiolytic-like activity of DOI (a 5-HT(2A/2C) agonist) in the four-plate test in mice
    Fabienne Masse
    EA 3256 Neurobiologie de l Anxiété et de la Dépression, Faculte de Medecine, BP 53508, 1 rue Gaston Veil, F44035 Nantes Cedex 01, France
    Eur Neuropsychopharmacol 17:483-91. 2007
    ..Flumazenil and CGP 35348 had no effect on the anxiolytic-like activity of DOI. These results suggest that the GABA system seems to be strongly implicated in the anxiolytic-like activity of DOI in the FPT...
  43. ncbi request reprint The four-plates test: anxiolytic or analgesic paradigm?
    Nadège Ripoll
    EA 3256, Neurobiologie de l anxiété et de la dépression, Faculte de Medecine, BP 53508, 1 rue Gaston Veil, F44035 Nantes Cedex 01, France
    Prog Neuropsychopharmacol Biol Psychiatry 30:873-80. 2006
    ..Our results suggest that the reported drug-induced anti-punishment effects in the FPT are not related to modifications of pain threshold but to a pure anxiolytic-like effect...
  44. ncbi request reprint Anxiolytic profile of HG1, a 5-HT-moduline antagonist, in three mouse models of anxiety
    Florence Clénet
    EA 3256 Neurobiologie de l Anxiété et de la Dépression, Faculte de Medecine, BP 53508, 1 rue Gaston Veil, 44035 Nantes Cedex 01, France
    Eur Neuropsychopharmacol 14:449-56. 2004
    ..We cannot exclude that it might also act through 5-HT receptors and rather have the profile of a selective serotonin reuptake inhibitor...
  45. ncbi request reprint Role of GABA-ergic and serotonergic systems in the anxiolytic-like mechanism of action of a 5-HT-moduline antagonist in the mouse elevated plus maze
    Florence Clénet
    EA 3256, Neurobiologie de l anxiété et de la dépression, Faculte de Medecine, BP 53508, 1 rue Gaston Veil, 44035 Nantes Cedex 01, France
    Behav Brain Res 158:339-48. 2005
    ....
  46. ncbi request reprint A follow-up study of a population of schizophrenic patients treated with clozapine
    M Bourin
    , SHUP, Hĵpital St-Jacques, Nantes, France
    Prog Neuropsychopharmacol Biol Psychiatry 25:1481-95. 2001
    ..e. female patients and subjects with a lower leukocyte base-line...
  47. ncbi request reprint Comparative pharmacokinetic study of conventional and sustained-release viloxazine in normal volunteers
    M F Kergueris
    Department of Pharmacology, Faculty of Medicine, Nantes, France
    Neuropsychobiology 20:136-40. 1989
    ..Despite the great interindividual variation this new viloxazine form appears to be of interest for one daily administration...
  48. ncbi request reprint Drug mechanisms in anxiety
    M Bourin
    Address JE 2029 Neurobiologie de l Anxiété et de la Depression, Faculte de Medecine, Nantes, France
    Curr Opin Investig Drugs 2:259-65. 2001
    ....
  49. ncbi request reprint Anxiolytic-like effects of DOI microinjections into the hippocampus (but not the amygdala nor the PAG) in the mice four plates test
    Fabienne Masse
    EA 3256, Neurobiologie de l anxiété et de la dépression, Faculte de Medecine, Nantes Cedex 01, France
    Behav Brain Res 188:291-7. 2008
    ..These results help us to understand mechanisms of action of DOI in animal models of anxiety, probably through an interaction with other neurotransmitter system, which may take place in the hippocampus...
  50. ncbi request reprint Temporal parameters of one-trial tolerance to benzodiazepines in four-plate test-retest
    Benoit Petit-Demouliere
    EA 3256 Neurobiologie de l Anxiété et de la Dépression, Faculte de Medecine, BP 53508, 1 rue Gaston Veil, F44035 Nantes Cedex 01, France
    Behav Brain Res 183:222-5. 2007
    ..Complete spatial representation of FPT seems to be responsible of this one-trial tolerance, and needs at least a 30s exposure to the apparatus to be completed, with or without punishments...
  51. ncbi request reprint [Iprindole: a functional link between serotonin and noradrenaline systems?]
    H Ganry
    Département de Pharmacologie et Gis Médicament, Faculte de Medecine, Nantes
    Encephale 20:7-11. 1994
    ..The aim of this interaction was to define the beta-adrenergic property of iprindole more precisely.(ABSTRACT TRUNCATED AT 250 WORDS)..
  52. ncbi request reprint First report of mirtazapine-induced arthralgia
    P Jolliet
    Laboratory of Pharmacology, University of Nantes, 1 rue Gaston Veil, 44035 Nantes cedex 1, France
    Eur Psychiatry 16:503-5. 2001
    ..The aim of our work is to describe the first two cases of arthralgia associated with the antidepressant drug mirtazapine...
  53. ncbi request reprint [Disinhibition effects of benzodiazepines]
    M Bourin
    EA3256 Neurobiologie de l anxiété et de la dépression, Faculté de Médecine de Nantes, 1, rue Gaston Veil, BP 53508, 44035 Nantes
    Encephale 29:S3-7. 2003
  54. ncbi request reprint [Mechanism of action of antidepressants and therapeutic perspectives]
    M Bourin
    Laboratoire de Neuropharmacologie UPRES EAD MENRT, Institut de signalisation et d innovation thérapeutique IFR75, Faculte de Pharmacie, Universite Paris Sud, Chatenay Malabry, France
    Therapie 57:385-96. 2002
    ..The use of antidepressants in anxiety disorders such as obsessional compulsive disorders and even generalised anxiety, highlights the distinction between antidepressants and classic anxiolytics such as benzodiazepines, or even buspirone...
  55. pmc Clonidine potentiates the effects of tranylcypromine, phenelzine and two analogues in the forced swimming test in mice
    Michel Bourin
    Neurochemical Research Unit, Department of Psychiatry, University of Alberta, Edmonton, Alta
    J Psychiatry Neurosci 27:178-85. 2002
    ....
  56. ncbi request reprint Nicotinic receptors and Alzheimer's disease
    Michel Bourin
    Research Group Neurobiology of Anxiety and Depression, Faculty of Medicine, Nantes, France
    Curr Med Res Opin 19:169-77. 2003
    ....
  57. ncbi request reprint Pharmacotherapy of anxious disorders
    Michel Bourin
    Neurobiology of Anxiety and Depression, Faculty of Medicine, BP 53508, 44035 Nantes cedex 1, France
    Hum Psychopharmacol 17:383-400. 2002
    ..For all these disorders there are proposals of treatment built on literature data mainly on meta-analysis as well on personal experience...
  58. ncbi request reprint The mouse light/dark box test
    Michel Bourin
    Faculty of Medicine, EA 3256 Neurobiologie de l Anxiété et de la Dépression, Faculté de Médecine BP 53508, 44035 Nantes cedex 1, France
    Eur J Pharmacol 463:55-65. 2003
    ..g. serotonergic drugs or drugs acting on neuropeptide receptors) can be detected using this paradigm. It has the advantages of being quick and easy to use, without requiring the prior training of animals...
  59. ncbi request reprint Use of paroxetine for the treatment of depression and anxiety disorders in the elderly: a review
    Michel Bourin
    Neurobiology of Anxiety and Depression, Faculty of Medicine, Nantes, France
    Hum Psychopharmacol 18:185-90. 2003
    ..In summary, paroxetine is well tolerated in the treatment of depression in those between the ages of 65 and 75, although few studies have examined its use in those of 75 and older...
  60. ncbi request reprint Monoamine metabolism changes following the mouse forced swimming test but not the tail suspension test
    Caroline E Renard
    EA 3256 Neurobiologie de l Anxiété et de la Dépression, Faculte de Medecine, BP 53508, 1 rue Gaston Veil, 44035 Nantes Cedex 01, France
    Fundam Clin Pharmacol 17:449-55. 2003
    ..The same effect was observed after a TST of 8 min and onwards. This study confirms the fact that although these two tests are used to study depression, they involve different neuronal mechanisms...
  61. ncbi request reprint Preclinical and clinical pharmacology of cyamemazine: anxiolytic effects and prevention of alcohol and benzodiazepine withdrawal syndrome
    Michel Bourin
    Neurobiology of Anxiety and Depression, Faculty of Medicine, BP 53508, 44035 Nantes, Cedex 1, France
    CNS Drug Rev 10:219-29. 2004
    ..This potential indication for cyamemazine and its activity in benzodiazepine withdrawal syndrome have recently been investigated in clinical trials and the results of these studies are presented in this review...
  62. pmc Antidepressant-like activity of S 20098 (agomelatine) in the forced swimming test in rodents: involvement of melatonin and serotonin receptors
    Michel Bourin
    EA 3256, Neurobiologie de l anxiété et de la dépression, Faculte de Medecine, Nantes, France
    J Psychiatry Neurosci 29:126-33. 2004
    ..To study agomelatine (S 20098), a potent agonist at melatonin receptors and antagonist at serotonin-2C (5-HT(2C)) receptors, in an animal model of depression, namely, the rodent forced swimming test (FST)...
  63. ncbi request reprint Mean Deviation of Inter-rater Scoring (MDIS): a simple tool for introducing conformity into groups of clinical investigators
    Michel Bourin
    Société nantaise de Psychiatrie biologique, Nantes, France
    Int Clin Psychopharmacol 19:209-13. 2004
    ..Finally, such a method could also be employed by experts to evaluate the quality of videotape-recorded clinical cases used in clinical trials, as well as by teachers to evaluate initial or continuous medical training...
  64. ncbi request reprint Is dopamine a limiting factor of the antidepressant-like effect in the mouse forced swimming test?
    Caroline E Renard
    EA 3256 Neurobiologie de l Anxiété et de la Dépression, Faculte de Medecine, BP 53508, 1 rue Gaston Veil, Nantes Cedex 01 44035, France
    Prog Neuropsychopharmacol Biol Psychiatry 28:1255-9. 2004
    ....
  65. ncbi request reprint Effect of antidepressant drugs on 6-OHDA-treated mice in the FST
    F Chenu
    Neurobiologie de l anxiété et de la dépression, EA 3256, Faculte de Medecine, 1 rue Gaston Veil, 44035 Nantes Cedex, France
    Eur Neuropsychopharmacol 17:187-93. 2007
    ..It could then be suggested that antidepressant-like effect of selective serotonin reuptake inhibitors (paroxetine and citalopram) in the mice FST requires the activation of dopaminergic pathways to occur...
  66. ncbi request reprint Paroxetine: a review
    M Bourin
    Neurobiology of Anxiety and Depression, Faculty of Medicine, BP 53508, F 44035 Nantes Cedex 1, France
    CNS Drug Rev 7:25-47. 2001
    ..Serious adverse events are, however, extremely rare even in overdose. In summary, paroxetine is well tolerated and effective in the treatment of both depressive and anxiety disorders across the age range...
  67. ncbi request reprint Treatment of acute mania--from clinical trials to recommendations for clinical practice
    Michel Bourin
    EA 3256 Neurobiologie de l Anxiété et de la Dépression, Faculte de Medecine, 1 rue Gaston Veil, BP 53508 44035 Nantes Cedex 01 France
    Hum Psychopharmacol 20:15-26. 2005
    ..However, from the standpoint of clinical trials currently available, even though antipsychotic agents are certainly effective in reducing the scores on the mania scales, can they be considered purely as antimania treatments?..
  68. ncbi request reprint Dopamine, depression and antidepressants
    Eric Dailly
    EA 3256 Neurobiologie de l Anxiété et de la Dépression, Faculte de Medecine, BP 53508, 1 rue Gaston Veil, 44035 Nantes Cedex 01, France
    Fundam Clin Pharmacol 18:601-7. 2004
    ..This paradoxical result suggests that further investigations are necessary to understand the role played by dopamine in depression...
  69. ncbi request reprint High-performance liquid chromatographic assay to determine the plasma levels of HIV-protease inhibitors (amprenavir, indinavir, nelfinavir, ritonavir and saquinavir) and the non-nucleoside reverse transcriptase inhibitor (nevirapine) after liquid-liquid e
    E Dailly
    Laboratoire de Pharmacologie Clinique, Institut de Biologie, Centre Hospitalier-Universitaire, Nantes, France
    J Chromatogr B Biomed Sci Appl 758:129-35. 2001
    ..2 mg/l (indinavir, saquinavir, nelfinavir) and 0.4 mg/l (ritonavir, nevirapine). This method which allows to estimate simultaneously plasma levels of protease inhibitors and nevirapine can be used for therapeutic drug monitoring...
  70. ncbi request reprint Negative symptoms, depression and Alzheimer's disease
    Martine Vercelletto
    Clinique Neurologique, CHU Nord, Nantes, France
    Int J Geriatr Psychiatry 17:383-7. 2002
    ....
  71. ncbi request reprint Forced swimming test in mice: a review of antidepressant activity
    Benoit Petit-Demouliere
    EA 3256 Neurobiologie de l Anxiété et de la Dépression, Faculte de Medecine, BP 53508, 1 rue Gaston Veil, F44035 Nantes Cedex 01, France
    Psychopharmacology (Berl) 177:245-55. 2005
    ..Among all animal models, the forced swimming test (FST) remains one of the most used tools for screening antidepressants...
  72. ncbi request reprint Effects of administration route on pharmacokinetics of viloxazine in the rabbit
    P Thomare
    Department of Pharmacology, Faculty of Medicine, Nantes, France
    Methods Find Exp Clin Pharmacol 14:125-9. 1992
    ..13. The other pharmacokinetic parameters such as half-life, clearance and volume of distribution where the same irregardless of the administration route...
  73. ncbi request reprint [Characteristics of hypersensitivity syndrome to lamotrigine: review of one case reported in the Regional Center of Pharmacovigilance of Nantes]
    G Veyrac
    Centre Regional de Pharmacovigilance, CHU, Institut de Biologie, Nantes, France
    Therapie 57:289-96. 2002
    ..Prompt recognition and withdrawal of the suspected drug is essential. The goal of research is to describe a "susceptibility profile" identifying individuals at risk for these forms of drug toxicity...
  74. ncbi request reprint The use of benzodiazepines in the aged patient: clinical and pharmacological considerations
    Eric Dailly
    EA 3256 Neurobiologie de l Anxiété et de la Dépression, Faculte de Medecine, BP 53508 1, rue Gaston Veil, 44035 Nantes Cedex 01, France
    Pak J Pharm Sci 21:144-50. 2008
    ....
  75. ncbi request reprint Lamotrigine-induced neutropenia following two attempts to increase dosage above 50 mg/day with recovery between episodes
    Olivier Lambert
    Centre Regional de Pharmacovigilance, Institut de Biologie, Nantes, France
    Adverse Drug React Toxicol Rev 21:157-9. 2002
  76. ncbi request reprint The other face of depression, reduced positive affect: the role of catecholamines in causation and cure
    David Nutt
    University of Bristol Psychopharmacology Unit, Bristol, UK
    J Psychopharmacol 21:461-71. 2007
    ..Focusing treatment on the predominant or driving symptomatology for an individual patient with major depression could potentially improve rates of response and remission...
  77. ncbi request reprint Distinct changes in the behavioural effects of morphine and naloxone in CCK2 receptor-deficient mice
    Kertu Rünkorg
    Department of Physiology, Biomedicum, University of Tartu, 19 Ravila Street, Tartu 50411, Estonia
    Behav Brain Res 144:125-35. 2003
    ..These behavioural alterations can be explained in the light of data that the targeted mutation of CCK(2) receptors induces distinct changes in the properties of opioid receptors in various brain structures...
  78. ncbi request reprint Targeted mutation of CCK2 receptor gene modifies the behavioural effects of diazepam in female mice
    Sirli Raud
    Department of Physiology, Biomedicum, University of Tartu, 19 Ravila Street, 50411 Tartu, Estonia
    Psychopharmacology (Berl) 168:417-25. 2003
    ..Evidence suggests that GABA and CCK have opposite roles in the regulation of anxiety...
  79. ncbi request reprint Antidepressant- and anxiolytic-like effects of selective neuronal NOS inhibitor 1-(2-trifluoromethylphenyl)-imidazole in mice
    Vallo Volke
    Department of Physiology, University of Tartu, 19 Ravila Street, Estonia
    Behav Brain Res 140:141-7. 2003
    ..We conclude that neuronal NOS seems to play the key role in the antidepressant- and anxiolytic-like effects of NOS inhibitors...
  80. ncbi request reprint Improved efficacy of fluoxetine in increasing hippocampal 5-hydroxytryptamine outflow in 5-HT(1B) receptor knock-out mice
    Isabelle Malagié
    Laboratoire de Neuropharmacologie UPRES EAD MENRT, Faculté de Pharmacie IFR ISIT Institut de Signalisation et d Innovation Thérapeutique, Universite Paris Sud, Tour D1 2eme etage 5 rue 1 B Clement, 92296, Chatenay Malabry Cedex, France
    Eur J Pharmacol 443:99-104. 2002
    ..Alternative mechanisms, e.g., changes in 5-HT transporter and/or 5-HT(1A) receptor density in 5-HT(1B) receptor knock-out mice could also explain these findings...
  81. ncbi request reprint Specificity and efficacy of noradrenaline, serotonin depletion in discrete brain areas of Swiss mice by neurotoxins
    Eric Dailly
    EA Neurobiologie de l Anxiété et la Dépression, Faculté de Médecine de Nantes, Laboratoire de Pharmacologie Clinique, Institut de Biologie, Centre Hospitalier Universitaire, 9 quai Moncousu, 44093 Nantes Cedex 1, France
    J Neurosci Methods 150:111-5. 2006
    ..In conclusion, DSP-4 has a different efficacy in discrete brain areas with a noradrenergic specificity which is not absolute, PCPA has a similar efficacy in all brain areas but is unspecific of 5-HT transmission...
  82. ncbi request reprint Bipolar disorder: how far are we from a rigorous definition and effective management?
    Gerard Emilien
    Wyeth Research, Clinical Neuroscience Programs, Coeur Défense Tour A La Défense 4, 92931 Paris La Défense Cedex, France
    Prog Neuropsychopharmacol Biol Psychiatry 31:975-96. 2007
    ..The successful management of bipolar disorder clearly demands improved recognition of bipolar disorder and effective long-term treatment for bipolar depression as well as mania...
  83. ncbi request reprint Different pathways mediated by CCK1 and CCK2 receptors: effect of intraperitonal mrna antisense oligodeoxynucleotides to cholecystokinin on anxiety-like and learning behaviors in rats
    Hagit Cohen
    Ministry of Health Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Depress Anxiety 20:139-52. 2004
    ..The present study showed an anxiolytic effect of i.p. CCK-ASODN in the presence of CCK2R, but not CCK1R...
  84. ncbi request reprint Effects of acute fluoxetine, paroxetine and desipramine on rats tested on the elevated plus-maze
    Dominique Drapier
    service hospitalo universitaire de psychiatrie, Centre Hospitalier Guillaume Regnier, 108 avenue du Général Leclerc, 35703 Rennes Cedex, France
    Behav Brain Res 176:202-9. 2007
    ..The elevated plus-maze exhibits good sensitivity for detecting anxiogenic effects of antidepressant drugs and the conventional parameters are sufficient and reliable for detecting such effects...
  85. ncbi request reprint [Treatment of acute mania]
    Michel Bourin
    Encephale 31:537-8. 2005
  86. ncbi request reprint Blockade of 5-HT1A receptors by (+/-)-pindolol potentiates cortical 5-HT outflow, but not antidepressant-like activity of paroxetine: microdialysis and behavioral approaches in 5-HT1A receptor knockout mice
    Jean Philippe Guilloux
    Laboratoire de Neuropharmacologie EA 3544, Faculte de Pharmacie, Universite Paris Sud, Chatenay Malabry Cedex, France
    Neuropsychopharmacology 31:2162-72. 2006
    ....
  87. ncbi request reprint Effectiveness of aripiprazole v. haloperidol in acute bipolar mania: double-blind, randomised, comparative 12-week trial
    Eduard Vieta
    Director of Research, Clinical Institute of Neuroscience, Hospital Clinic, University of Barcelona, Spain
    Br J Psychiatry 187:235-42. 2005
    ..Despite several treatmentoptions, adherenceto therapy is poor in patients with bipolar disorder...
  88. ncbi request reprint Effect of intraperitoneal mRNA antisense-oligodeoxynucleotides to cholecystokinin on anxiety-like and learning behaviors in rats: association with pre-experimental stress
    Hagit Cohen
    Ministry of Health Mental Health Center, Faculty of Health Sciences, Anxiety and Stress Research Unit, Ben Gurion University of the Negev, Beer Sheva, Israel
    Neuropeptides 36:341-52. 2002
    ..We demonstrated that intracerebroventricular administration of Cholecystokinin-antisense oligodeoxynucleotides (ASODN) for 3 days significantly diminished anxiety-like behavior in rats...
  89. ncbi request reprint Altered pain sensitivity and morphine-induced anti-nociception in mice lacking CCK2 receptors
    Alar Veraksits
    Department of Physiology, Biomedicum, University of Tartu, 19 Ravila Street, 50411, Tartu, Estonia
    Psychopharmacology (Berl) 166:168-75. 2003
    ..Cholecystokinin (CCK) interacts with the endopioid system in the regulation of various physiological functions, including the control of pain sensitivity, motor activity and emotional behaviour...
  90. ncbi request reprint Deletion of the CCK2 receptor gene reduces mechanical sensitivity and abolishes the development of hyperalgesia in mononeuropathic mice
    Kaido Kurrikoff
    Department of Physiology, University of Tartu, 19 Ravila Street, 50411 Tartu, Estonia
    Eur J Neurosci 20:1577-86. 2004
    ..Our study suggests that not only pain sensitivity, but also mechanical sensitivity and the development of neuropathic pain are regulated by antagonistic interactions between CCK and opioid systems...
  91. ncbi request reprint [Impacts of the new flunitrazepam regulations on the consumption of hypnotics]
    Caroline Victorri-Vigneau
    CEIP CHRU Hôtel Dieu, Nantes, France
    Therapie 58:425-30. 2003
    ..Although many hypotheses can be offered to account for this phenomenon, it seems that many consumers halted their consumption of flunitrazepam as a result of the new regulatory regime...
  92. ncbi request reprint [Tramadol and oral anticoagulants: interaction or confounding factors?]
    Anne Chiffoleau
    Therapie 58:471-4. 2003
  93. ncbi request reprint Sedation, an unpleasant, undesirable and potentially dangerous side-effect of many psychotropic drugs
    Michel Bourin
    EA 3256 Neurobiologie de l Anxiété et de la Dépression, Faculty of Medicine, B P 53508 44035 Nantes cédex 01, France
    Hum Psychopharmacol 19:135-9. 2004
    ..This article discusses the sedative properties and mechanisms of different classes of psychotropic drugs...
  94. ncbi request reprint A review of clozapine safety
    Joanna Fitzsimons
    Department of Clinical and Biomedical Sciences, Barwon Health, Swanston Centre, University of Melbourne, PO Box 281, Geelong, Victoria 3220, Australia
    Expert Opin Drug Saf 4:731-44. 2005
    ..Understanding the safety profile of clozapine allows an informed use of the agent that can maximise its clear clinical benefit and minimise the known risks...
  95. ncbi request reprint Nicotinic receptors and schizophrenia
    Nadège Ripoll
    Neurobiology of Anxiety and Depression Research Group, Faculty of Medicine, University of Nantes, France
    Curr Med Res Opin 20:1057-74. 2004
    ..This review assesses the involvement of the nicotinic system in schizophrenia and suggests ways in which this system may participate in the pathophysiology of this disease...