Catherine Bourgain

Summary

Country: France

Publications

  1. pmc Use of closely related affected individuals for the genetic study of complex diseases in founder populations
    C Bourgain
    Unité de Recherche d Epidémiologie Génétique, INSERM U535, 94276 Le Kremlin Bicêtre Cedex France
    Am J Hum Genet 68:154-159. 2001
  2. ncbi request reprint Search for multifactorial disease susceptibility genes in founder populations
    C Bourgain
    Unité de Recherche d Epidémiologie Génétique, INSERM U535, Batiment Gregory Pincus, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre cedex, France
    Ann Hum Genet 64:255-65. 2000
  3. ncbi request reprint Missing data in haplotype analysis: a study on the MILC method
    C Bourgain
    Unité de Recherche d Epidémiologie Génétique, INSERM U535, Kremlin Bicetre, France
    Ann Hum Genet 66:99-108. 2002
  4. ncbi request reprint Comparison of family based haplotype methods using intragenic SNPs in candidate genes
    Catherine Bourgain
    Unité de Recherche d Epidémiologie Génétique, INSERM U535, Kremlin Bicetre, France
    Eur J Hum Genet 10:313-9. 2002
  5. pmc Detection of susceptibility loci by genome-wide linkage analysis
    Marie Claude Babron
    INSERM U535, 94817 Villejuif Cedex, Villejuif, France
    BMC Genet 6:S18. 2005
  6. doi request reprint A multiple splitting approach to linkage analysis in large pedigrees identifies a linkage to asthma on chromosome 12
    Celine Bellenguez
    Univ Paris Sud, UMR_S535, Villejuif, France
    Genet Epidemiol 33:207-16. 2009
  7. pmc A mixture model approach to multiple testing for the genetic analysis of gene expression
    Cyril Dalmasso
    JE 2492 Universite Paris Sud, , 16 Avenue Paul Vaillant Couturier, Villejuif Cedex 94807, France
    BMC Proc 1:S141. 2007
  8. ncbi request reprint Are genome-wide association studies all that we need to dissect the genetic component of complex human diseases?
    Catherine Bourgain
    1INSERM U535, University Paris Sud, Villejuif F 94817, France
    Eur J Hum Genet 15:260-3. 2007
  9. pmc Modeling the effect of a genetic factor for a complex trait in a simulated population
    Mathieu Bourgey
    INSERM Unité 535, B P 1000, 94817 Villejuif Cedex, France
    BMC Genet 6:S87. 2005
  10. pmc Impact of the diagnosis definition on linkage detection
    Marie Hélène Dizier
    Hopital Paul Brousse, Bâtiment Leriche, B P 1000, 94817 Villejuif Cedex, France
    BMC Genet 6:S140. 2005

Collaborators

Detail Information

Publications21

  1. pmc Use of closely related affected individuals for the genetic study of complex diseases in founder populations
    C Bourgain
    Unité de Recherche d Epidémiologie Génétique, INSERM U535, 94276 Le Kremlin Bicêtre Cedex France
    Am J Hum Genet 68:154-159. 2001
    ..We used the MILC approach to analyze the role of HLA in celiac disease and showed that the effect of HLA may be detected with the MILC approach by typing only 11 affected individuals, who were part of a single large Finnish pedigree...
  2. ncbi request reprint Search for multifactorial disease susceptibility genes in founder populations
    C Bourgain
    Unité de Recherche d Epidémiologie Génétique, INSERM U535, Batiment Gregory Pincus, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre cedex, France
    Ann Hum Genet 64:255-65. 2000
    ..It is thus appropriate for a search for common genetic risk factors for complex diseases. Statistical properties of the method are discussed in realistic contexts...
  3. ncbi request reprint Missing data in haplotype analysis: a study on the MILC method
    C Bourgain
    Unité de Recherche d Epidémiologie Génétique, INSERM U535, Kremlin Bicetre, France
    Ann Hum Genet 66:99-108. 2002
    ..A real situation is considered where data are derived from a genome screen for asthma susceptibility alleles in the Hutterites. Results are illustrated on this asthma data set...
  4. ncbi request reprint Comparison of family based haplotype methods using intragenic SNPs in candidate genes
    Catherine Bourgain
    Unité de Recherche d Epidémiologie Génétique, INSERM U535, Kremlin Bicetre, France
    Eur J Hum Genet 10:313-9. 2002
    ....
  5. pmc Detection of susceptibility loci by genome-wide linkage analysis
    Marie Claude Babron
    INSERM U535, 94817 Villejuif Cedex, Villejuif, France
    BMC Genet 6:S18. 2005
    ..Our results for the individual replicates are consistent with the disease model used in the simulation...
  6. doi request reprint A multiple splitting approach to linkage analysis in large pedigrees identifies a linkage to asthma on chromosome 12
    Celine Bellenguez
    Univ Paris Sud, UMR_S535, Villejuif, France
    Genet Epidemiol 33:207-16. 2009
    ..The detection of a genome-wide significant linkage for asthma on chromosome 12q21 illustrates the potential of this multiple splitting approach...
  7. pmc A mixture model approach to multiple testing for the genetic analysis of gene expression
    Cyril Dalmasso
    JE 2492 Universite Paris Sud, , 16 Avenue Paul Vaillant Couturier, Villejuif Cedex 94807, France
    BMC Proc 1:S141. 2007
    ..The contribution of our model to estimation of FDR and related criteria is illustrated on the microarray expression profiles data set provided by the Genetic Analysis Workshop 15 Problem 1...
  8. ncbi request reprint Are genome-wide association studies all that we need to dissect the genetic component of complex human diseases?
    Catherine Bourgain
    1INSERM U535, University Paris Sud, Villejuif F 94817, France
    Eur J Hum Genet 15:260-3. 2007
    ....
  9. pmc Modeling the effect of a genetic factor for a complex trait in a simulated population
    Mathieu Bourgey
    INSERM Unité 535, B P 1000, 94817 Villejuif Cedex, France
    BMC Genet 6:S87. 2005
    ..However, we could not find any model that could explain the familial segregation of the trait, namely the higher proportion of affected parents than affected sibs...
  10. pmc Impact of the diagnosis definition on linkage detection
    Marie Hélène Dizier
    Hopital Paul Brousse, Bâtiment Leriche, B P 1000, 94817 Villejuif Cedex, France
    BMC Genet 6:S140. 2005
    ..A genetic factor located on the chromosome 1 may have been detected here which would be involved specifically in traits a and b or in a combination of these traits...
  11. pmc Novel case-control test in a founder population identifies P-selectin as an atopy-susceptibility locus
    Catherine Bourgain
    Department of Human Genetics, University of Chicago, Chicago, IL, USA
    Am J Hum Genet 73:612-26. 2003
    ..10-6) between atopy and an amino acid polymorphism in the P-selectin gene, detected with the QLS test and also, but less significantly (P=.0014), with the transmission/disequilibrium test...
  12. pmc Linkage analysis with dense SNP maps in isolated populations
    Celine Bellenguez
    Universite Paris Sud, UMR_S535, Villejuif, France
    Hum Hered 68:87-97. 2009
    ..We investigate the issue of linkage analysis with SNPs from the Affymetrix 500K GeneChip array in extended families from the isolated Hutterite population...
  13. pmc Testing for Hardy-Weinberg equilibrium in samples with related individuals
    Catherine Bourgain
    INSERM U535, 94817 Villejuif Cedex, France
    Genetics 168:2349-61. 2004
    ..Finally, the method is used to test a set of 143 biallelic markers spanning 82 genes in this latter population...
  14. ncbi request reprint Complex trait mapping in isolated populations: Are specific statistical methods required?
    Catherine Bourgain
    1INSERM U535, Hopital Paul Brousse, Villejuif, France
    Eur J Hum Genet 13:698-706. 2005
    ..We show that methods designed for outbred samples are generally not appropriate for isolated populations and could lead to false conclusions...
  15. pmc Comparing strategies for association mapping in samples with related individuals
    Catherine Bourgain
    INSERM U535, Hopital Paul Brousse, Batiment Leriche B P 1000, 94817 Villejuif Cedex, France
    BMC Genet 6:S98. 2005
    ..Using a correction factor for the case-control test performed conditional on the marker information rather than unconditional does not impact the power significantly...
  16. pmc Common variants in the BMP2, BMP4, and HJV genes of the hepcidin regulation pathway modulate HFE hemochromatosis penetrance
    Jacqueline Milet
    INSERM U535, Villejuif, France
    Am J Hum Genet 81:799-807. 2007
    ..Our results also highlight the BMP regulation pathway as a good candidate for identification of new modifier genes...
  17. ncbi request reprint New susceptibility locus for hypertension on chromosome 8q by efficient pedigree-breaking in an Italian isolate
    Marina Ciullo
    Institute of Genetics and Biophysics, A Buzzati Traverso, CNR Naples, Italy
    Hum Mol Genet 15:1735-43. 2006
    ..This work both identifies a new locus strongly linked to hypertension and shows that the power of linkage analysis can be improved by the appropriate use of efficient pedigree-breaking strategies...
  18. pmc Power of genome-wide association studies in the presence of interacting loci
    Joseph Pickrell
    INSERM, U535, Villejuif, France
    Genet Epidemiol 31:748-62. 2007
    ..We find that this assumption does not introduce much error in single locus models of disease, but may do so in so in certain two-locus models...
  19. ncbi request reprint Identification and replication of a novel obesity locus on chromosome 1q24 in isolated populations of Cilento
    Marina Ciullo
    Institute of Genetics and Biophysics A Buzzati Traverso, CNR, Via Pietro Castellino, 111, 80131 Naples, Italy
    Diabetes 57:783-90. 2008
    ..Studying isolated populations can be a useful approach to identify rare variants that will not be detected with whole-genome association studies in large populations...
  20. ncbi request reprint Are common disease susceptibility alleles the same in outbred and founder populations?
    Dina L Newman
    Department of Human Genetics, University of Chicago, Chicago, IL, USA
    Eur J Hum Genet 12:584-90. 2004
    ..05), with five loci remaining significant after adjusting for multiple comparisons. These data indicate that this founder population is informative and offers considerable advantages for genetic studies of common complex diseases...
  21. pmc Progressive retinal atrophy in the Border Collie: a new XLPRA
    Thierry Vilboux
    IGDR CNRS, Genetique et Developpement, Faculte de Medecine, Universite de Rennes1, 35043 Rennes Cedex, France
    BMC Vet Res 4:10. 2008
    ....