Henri-Marc Bourbon

Summary

Affiliation: Centre de Biologie du Développement
Location: Toulouse, France
Publications:
1. Bugler, B., M. Caizergues-Ferrer, G. Bouche, H.M. Bourbon and F. Amalric (1982). Detection and localization of a class of proteins immunologically related to a 100-kDa nucleolar protein. Eur J Biochem 128: 475-80.

2. Bourbon, H.M., B. Bugler, M. Caizergues-Ferrer, F. Amalric and J. P. Zalta (1983). Maturation of a 100 kDa protein associated with preribosomes in Chinese hamster ovary cells. Mol Biol Rep 9: 39-47.

3. Bourbon, H.M., B. Bugler, M. Caizergues-Ferrer and F. Amalric (1983). Role of phosphorylation on the maturation pathways of a 100 kDa nucleolar protein. FEBS Lett 155: 218-22.

4. Bugler, B., H.M. Bourbon, B. Lapeyre, M. O. Wallace, J. H. Chang et al. (1987). RNA binding fragments from nucleolin contain the ribonucleoprotein consensus sequence. J Biol Chem 262: 10922-5.

5. Lapeyre, B., H.M. Bourbon and F. Amalric (1987). Nucleolin, the major nucleolar protein of growing eukaryotic cells: an unusual protein structure revealed by the nucleotide sequence. Proc Natl Acad Sci U S A 84: 1472-6.

6. Bourbon, H.M., B. Lapeyre and F. Amalric (1988). Structure of the mouse nucleolin gene. The complete sequence reveals that each RNA binding domain is encoded by two independent exons. J Mol Biol 200: 627-38.

7. Bourbon, H.M., B. Michot, N. Hassouna, J. Feliu and J. P. Bachellerie (1988). Sequence and secondary structure of the 5 external transcribed spacer of mouse pre-rRNA. DNA 7: 181-91

8. Bourbon, H.M., M. Prudhomme and F. Amalric (1988). Sequence and structure of the nucleolin promoter in rodents: characterization of a strikingly conserved CpG island. Gene 68: 73-84.

9. Bourbon, H.M., and F. Amalric (1990). Nucleolin gene organization in rodents: highly conserved sequences within three of the 13 introns. Gene 88: 187-96.

10. Bourbon, H.M., and F. Amalric (1991). Structure of an intronless mouse nucleolin pseudogene: insights into mechanisms enabling the conversion of RNA to DNA. Gene 101: 273-8.

11. Brand, S., and H.M. Bourbon (1993). The developmentally-regulated Drosophila gene rox8 encodes an RRM-type RNA binding protein structurally related to human TIA-1-type nucleolysins. Nucleic Acids Res 21: 3699-704.

12. Bourbon, H.M., E. Martin-Blanco, D. Rosen and T.B. Kornberg (1995). Phosphorylation of the Drosophila engrailed protein at a site outside its homeodomain enhances DNA binding. J Biol Chem 270: 11130-9.

13. Brand, S. F., S. Pichoff, S. Noselli and H.M. Bourbon (1995). Novel Drosophila melanogaster genes encoding RRM-type RNA-binding proteins identified by a degenerate PCR strategy. Gene 154: 187-92.

14. Glise, B., H.M. Bourbon and S. Noselli (1995). hemipterous encodes a novel Drosophila MAP kinase kinase, required for epithelial cell sheet movement. Cell 83: 451-61.

15. Perrin, L., P. Romby, P. Laurenti, H. Berenger, S. Kallenbach, H.M. Bourbon and J. Pradel (1999). The Drosophila modifier of variegation modulo gene product binds specific RNA sequences at the nucleolus and interacts with DNA and chromatin in a phosphorylation-dependent manner. J Biol Chem 274: 6315-23.

16. Labourier, E., E. Allemand, S. Brand, M. Fostier, J. Tazi and H.M. Bourbon (1999). Recognition of exonic splicing enhancer sequences by the Drosophila splicing repressor RSF1. Nucleic Acids Res 27: 2377-86.

17. Benoit, B., A. Nemeth, N. Aulner, U. Kuhn, M. Simonelig, E. Wahle and H.M. Bourbon (1999). The Drosophila poly(A)-binding protein II is ubiquitous throughout Drosophila development and has the same function in mRNA polyadenylation as its bovine homolog in vitro. Nucleic Acids Res 27: 3771-8.

18. Bourbon, H.M., E. Labourier, I. E. Gallouzi, M. Fostier, E. Allemand and J. Tazi (1999). Antagonism between RSF1 and SR proteins for both splice-site recognition in vitro and Drosophila development. Genes Dev 13: 740-53.

19. Boube, M., C. Faucher, L. Joulia, D. L. Cribbs and H.M. Bourbon (2000) Drosophila homologs of transcriptional mediator complex subunits are required for adult cell and segment identity specification. Genes Dev 14: 2906-2917.

20. Allemand, E., R. Gattoni, H.M. Bourbon, J. Stevenin, J. Caceres, J. Soret and J. Tazi (2001) Distinctive features of Drosophila SF2/ASF splicing factor RS domain: implication for specific phosphorylation, shuttling and splicing activation. Mol Cell Biol 21: 1345-1359.

21. Fauvarque, M.O., P. Laurenti, A. Boivin, S. Bloyer, R. Griffin-Shea, H.M. Bourbon, and J.M. Dura (2001). Dominant modifiers of the polyhomeotic extra-sex-combs phenotype induced by marked P element insertional mutagenesis in Drosophila. Genet Res 78: 137-148.

22. Bourbon, H.M., G. Gonzy-Treboul, F. Peronnet, M.F. Alin, C. Ardourel, C. Bennasayag, D. Cribbs, J. Deutsch, P. Ferrer, M. Haenlin, J.A. Lepesant, S. Noselli and A. Vincent (2002). A P-insertion screen identifying novel X-linked essential genes in Drosophila. Mech Dev 111: 71-83.

23. Calgaro, S., M. Boube, D.L. Cribbs and H.M. Bourbon (2002). The Drosophila gene taranis encodes a novel Trithorax group member potentially linked to the cell-cycle regulatory apparatus. Genetics 160: 547-560.

24 . Boube, M., L. Joulia, D.L. Cribbs and H.M. Bourbon (2002). Evidence for a Mediator of RNA polymerase II transcriptional regulation conserved from yeast to man. Cell 110: 143-151.

25. Bourbon, H.-M., et al. (2004). A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II. Mol Cell 14, 553-7.

26. Guglielmi, B., van Berken, N., Klapholz, B., Bijma, T., Boube, M., Boschiero, C., Bourbon, H.-M., Holstege, F.C.P., and Werner, M. (2004). A high resolution protein interaction map of the yeast Mediator complex. Nucleic Acids Res 32, 5379-91.

27. Joulia, L., Bourbon, H.-M., and Cribbs, D.L. (2005). Homeotic proboscipedia function modulates hedgehog-mediated organizer activity to pattern adult Drosophila mouthparts. Dev Biol 278, 496-510.

28. Colombié, N., Verollet, C., Sampaio, P., Moisand, A., Sunkel, C., Bourbon, H.-M., Wright, M., and Raynaud-Messina B. (2006). The Drosophila γ-tubulin small complex subunit Dgrip84 is required for structural and functional integrity of the spindle apparatus. Mol Biol Cell 17, 272-282.

29. Vérollet, C., Colombié, N., Daubon, Bourbon, H.-M., Wright, M., and Raynaud-Messina, B. (2006). Drosophila γ-TuRC is dispensable for targeting γ-tubulin to the centrosome and microtubule nucleation. J Cell Biol, 172, 517-528.

30. Joulia, L., Deutsch, Bourbon, H.-M., and Cribbs, D.L (2006). The specification of a highly derived arthropod appendage, the Drosophila labial palps, requires the joint action of selectors and signaling pathways. Dev Genes Evol 216, 431-42.

31. Loncle, N., Boube, M., Joulia, L., Boschiero, C., Werner, M., Cribbs, D.L., and Bourbon, H.M. (2007). Distinct roles for Mediator Cdk8 module subunits in Drosophila development. EMBO J, 26, 1045-1054.

32. Bourbon, H.M. (2008). Comparative genomics supports a deep evolutionary origin for the large, four-module transcriptional Mediator complex. Nucleic Acids Res, 36, 3993-4008.

33. Gobert, V., Osman, D., Bras, S., Augé, B., Boube, M., Bourbon, H.M., Horn, T., Boutros , M., Haenlin, M. and Waltzer, L. (2010). A genome-wide RNAi screen in Drosophila identifies a differential role of the Mediator CDK8 module subunits in GATA/RUNX-activated transcription. Mol Cell Biol, 30, 2837-48.

34. Kumar, R., Bourbon, H.M. and Massy, B. (2010). Functional conservation of Mei4 for meiotic DNA double-strand break formation from yeasts to mice. Genes and Dev, 24, 1266-80.

35. Makki, R., Meister, M., Pennetier, D., Ubeda, J.M., Braun, A. Daburon, V., Krzemien, J., Bourbon, H.M., Zhou, R., Vincent, A. and Crozatier, M. (2010). A short receptor down-regulates JAK/STAT signalling to control the Drosophila cellular immune response. PLOS Biology, 8, 8, e1000441.

Publications

  1. ncbi request reprint A P-insertion screen identifying novel X-linked essential genes in Drosophila
    Henri Marc Bourbon
    Centre de Biologie du Developpement, UMR 5547 CNRS UPS, 118 route de Narbonne, 31062 Toulouse Cedex, France
    Mech Dev 110:71-83. 2002
  2. pmc Comparative genomics supports a deep evolutionary origin for the large, four-module transcriptional mediator complex
    Henri Marc Bourbon
    Centre de Biologie du Developpement, UMR5547 CNRS Toulouse III, IFR109, Universite Paul Sabatier, 31062 Toulouse, France
    Nucleic Acids Res 36:3993-4008. 2008
  3. ncbi request reprint Nucleolin gene organization in rodents: highly conserved sequences within three of the 13 introns
    H M Bourbon
    Centre De Recherche de Biochimie et de Genetique Cellulaires du C N R S, Toulouse, France
    Gene 88:187-96. 1990
  4. pmc The Drosophila gene taranis encodes a novel trithorax group member potentially linked to the cell cycle regulatory apparatus
    Stéphane Calgaro
    Centre de Biologie du Developpement, Universite Paul Sabatier, 31062 Toulouse Cedex, France
    Genetics 160:547-60. 2002
  5. ncbi request reprint Evidence for a mediator of RNA polymerase II transcriptional regulation conserved from yeast to man
    Muriel Boube
    Centre de Biologie du Developpement, Universite Paul Sabatier, 31062, Toulouse Cedex, France
    Cell 110:143-51. 2002
  6. ncbi request reprint A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II
    Henri Marc Bourbon
    Mol Cell 14:553-7. 2004
  7. pmc A high resolution protein interaction map of the yeast Mediator complex
    Benjamin Guglielmi
    Service de Biochimie et Génétique Moléculaire, Bâtiment 144, CEA Saclay, 91191 Gif sur Yvette Cedex, France
    Nucleic Acids Res 32:5379-91. 2004
  8. ncbi request reprint Homeotic proboscipedia function modulates hedgehog-mediated organizer activity to pattern adult Drosophila mouthparts
    Laurent Joulia
    Centre de Biologie du Développement CNRS, 118 route de Narbonne, 31062 Toulouse Cedex 04, France
    Dev Biol 278:496-510. 2005
  9. ncbi request reprint The specification of a highly derived arthropod appendage, the Drosophila labial palps, requires the joint action of selectors and signaling pathways
    Laurent Joulia
    Centre de Biologie du Developpement, CNRS, 118 route de Narbonne, 31062 Toulouse Cedex 04, France
    Dev Genes Evol 216:431-42. 2006
  10. pmc Distinct roles for Mediator Cdk8 module subunits in Drosophila development
    Nicolas Loncle
    Centre de Biologie du Developpement, UMR5544 du CNRS, Universite Paul Sabatier, Toulouse Cedex 09, France
    EMBO J 26:1045-54. 2007

Collaborators

Detail Information

Publications26

  1. ncbi request reprint A P-insertion screen identifying novel X-linked essential genes in Drosophila
    Henri Marc Bourbon
    Centre de Biologie du Developpement, UMR 5547 CNRS UPS, 118 route de Narbonne, 31062 Toulouse Cedex, France
    Mech Dev 110:71-83. 2002
    ..ups-tlse.fr:8080/screen...
  2. pmc Comparative genomics supports a deep evolutionary origin for the large, four-module transcriptional mediator complex
    Henri Marc Bourbon
    Centre de Biologie du Developpement, UMR5547 CNRS Toulouse III, IFR109, Universite Paul Sabatier, 31062 Toulouse, France
    Nucleic Acids Res 36:3993-4008. 2008
    ..The implications of this comprehensive work for MED structure-function relationships are discussed...
  3. ncbi request reprint Nucleolin gene organization in rodents: highly conserved sequences within three of the 13 introns
    H M Bourbon
    Centre De Recherche de Biochimie et de Genetique Cellulaires du C N R S, Toulouse, France
    Gene 88:187-96. 1990
    ....
  4. pmc The Drosophila gene taranis encodes a novel trithorax group member potentially linked to the cell cycle regulatory apparatus
    Stéphane Calgaro
    Centre de Biologie du Developpement, Universite Paul Sabatier, 31062 Toulouse Cedex, France
    Genetics 160:547-60. 2002
    ..These data raise the possibility that TARA-alpha/-beta play a role in integrating chromatin structure with cell cycle regulation...
  5. ncbi request reprint Evidence for a mediator of RNA polymerase II transcriptional regulation conserved from yeast to man
    Muriel Boube
    Centre de Biologie du Developpement, Universite Paul Sabatier, 31062, Toulouse Cedex, France
    Cell 110:143-51. 2002
    ..Finally, we examine the implications of these observations for the physiological roles of metazoan MED subunits...
  6. ncbi request reprint A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II
    Henri Marc Bourbon
    Mol Cell 14:553-7. 2004
  7. pmc A high resolution protein interaction map of the yeast Mediator complex
    Benjamin Guglielmi
    Service de Biochimie et Génétique Moléculaire, Bâtiment 144, CEA Saclay, 91191 Gif sur Yvette Cedex, France
    Nucleic Acids Res 32:5379-91. 2004
    ..The resulting interaction map provides a framework for delineating Mediator structure-function and investigating how Mediator function is regulated...
  8. ncbi request reprint Homeotic proboscipedia function modulates hedgehog-mediated organizer activity to pattern adult Drosophila mouthparts
    Laurent Joulia
    Centre de Biologie du Développement CNRS, 118 route de Narbonne, 31062 Toulouse Cedex 04, France
    Dev Biol 278:496-510. 2005
    ..These results extend selector function to primary steps of tissue patterning, and lead us to suggest the notion of a homeotic organizer...
  9. ncbi request reprint The specification of a highly derived arthropod appendage, the Drosophila labial palps, requires the joint action of selectors and signaling pathways
    Laurent Joulia
    Centre de Biologie du Developpement, CNRS, 118 route de Narbonne, 31062 Toulouse Cedex 04, France
    Dev Genes Evol 216:431-42. 2006
    ..A crucial aspect of selector function in development and evolution may be in regulating diffusible signals, including those emitted by dpp and wg...
  10. pmc Distinct roles for Mediator Cdk8 module subunits in Drosophila development
    Nicolas Loncle
    Centre de Biologie du Developpement, UMR5544 du CNRS, Universite Paul Sabatier, Toulouse Cedex 09, France
    EMBO J 26:1045-54. 2007
    ..These data reveal functional attributes of the Cdk8 module, apart from its regulated kinase activity, that may contribute to the diversification of genetic programs...
  11. ncbi request reprint Dominant modifiers of the polyhomeotic extra-sex-combs phenotype induced by marked P element insertional mutagenesis in Drosophila
    M O Fauvarque
    Institut de Genetique Humaine, CNRS UPR 1142, 141 rue de la Cardonille, 34396 Montpellier, France
    Genet Res 78:137-48. 2001
    ..One such insertion enhanced the ph phenotype and we show that it is a new allele of UbcD1/eff, a gene encoding a ubiquitin-conjugating enzyme that is involved in telomere association and potentially in chromatin remodelling...
  12. pmc The Drosophila poly(A)-binding protein II is ubiquitous throughout Drosophila development and has the same function in mRNA polyadenylation as its bovine homolog in vitro
    B Benoit
    Dynamique du Génome et Evolution, Institut Jacques Monod, 2 place Jussieu, 75005 Paris, France
    Nucleic Acids Res 27:3771-8. 1999
    ....
  13. pmc Recognition of exonic splicing enhancer sequences by the Drosophila splicing repressor RSF1
    E Labourier
    Institut de Genetique Moleculaire, UMR5535 du CNRS, 1919 Route de Mende, F34293 Montpellier Cedex 5, France
    Nucleic Acids Res 27:2377-86. 1999
    ....
  14. ncbi request reprint Sequence and structure of the nucleolin promoter in rodents: characterization of a strikingly conserved CpG island
    H M Bourbon
    Centre de Recherche de Biochimie et de Génétique Cellulaires du Centre National de la Recherche Scientifique, Toulouse, France
    Gene 68:73-84. 1988
    ..Our findings shed some light on the putative role of the CpG island. We show that CpG-rich sequence motifs are under strong selective pressure over the whole 5'-terminal region and are presumably involved in regulatory mechanisms...
  15. ncbi request reprint Structure of the mouse nucleolin gene. The complete sequence reveals that each RNA binding domain is encoded by two independent exons
    H M Bourbon
    Centre de Recherche de Biochimie et de Genetique Cellulaires du CNRS, Toulouse, France
    J Mol Biol 200:627-38. 1988
    ..This latter result suggests that the RNA binding domains are composed of two independent subdomains, whose functions remain to be determined...
  16. pmc Nucleolin, the major nucleolar protein of growing eukaryotic cells: an unusual protein structure revealed by the nucleotide sequence
    B Lapeyre
    Proc Natl Acad Sci U S A 84:1472-6. 1987
    ..Five potential N glycosylation sites are detected. The structure of this protein may reflect two functions in preribosome biogenesis: interaction with chromatin (NH2 terminus) and with preribosomes (COOH terminus)...
  17. pmc Functional conservation of Mei4 for meiotic DNA double-strand break formation from yeasts to mice
    Rajeev Kumar
    Institut de Genetique Humaine, UPR1142, CNRS, 34396 Montpellier Cedex 5, France
    Genes Dev 24:1266-80. 2010
    ....
  18. ncbi request reprint Phosphorylation of the Drosophila engrailed protein at a site outside its homeodomain enhances DNA binding
    H M Bourbon
    Department of Biochemistry and Biophysics, University of California, San Francisco 94143, USA
    J Biol Chem 270:11130-9. 1995
    ..CK-II-dependent phosphorylation of an N-truncated derivative of engrailed protein purified from bacteria increased its DNA binding 2-4-fold...
  19. ncbi request reprint Novel Drosophila melanogaster genes encoding RRM-type RNA-binding proteins identified by a degenerate PCR strategy
    S F Brand
    Centre de Biologie du Developpement, UMR 9925 CNRS UPS, Universite Paul Sabatier, Toulouse, France
    Gene 154:187-92. 1995
    ..21 (1993) 3699-3704]...
  20. pmc The developmentally-regulated Drosophila gene rox8 encodes an RRM-type RNA binding protein structurally related to human TIA-1-type nucleolysins
    S Brand
    Centre de Biologie du Developpement, UMR 9925 CNRS UPS, Universite Paul Sabatier, Toulouse, France
    Nucleic Acids Res 21:3699-704. 1993
    ..Molecular characterization of rox8 represents the first step in a genetic analysis of the potential roles of a TIA-1-related protein in RNA metabolism and/or programmed cell death in Drosophila...
  21. ncbi request reprint hemipterous encodes a novel Drosophila MAP kinase kinase, required for epithelial cell sheet movement
    B Glise
    Centre de Biologie du Developpement, Centre National de la Recherche Scientifique, Toulouse, France
    Cell 83:451-61. 1995
    ..These data suggest that hep functions in a novel Drosophila MAPK pathway, controlling puckered expression and morphogenetic activity of the dorsal epidermis...
  22. ncbi request reprint The Drosophila modifier of variegation modulo gene product binds specific RNA sequences at the nucleolus and interacts with DNA and chromatin in a phosphorylation-dependent manner
    L Perrin
    Laboratoire de Génétique et de Biologie du Développement, Institut de Biologie du Developpement de Marseille, Parc Scientifique de Luminy, CNRS Case 907, 13288 Marseille Cedex 9, France
    J Biol Chem 274:6315-23. 1999
    ..A functional scheme is finally proposed in which modification by phosphorylation modulates Mod subnuclear distribution and balances its function at the nucleolus and chromatin...
  23. pmc Antagonism between RSF1 and SR proteins for both splice-site recognition in vitro and Drosophila development
    E Labourier
    Institut de Genetique Moleculaire, Centre National de la Recherche Scientifique CNRS, F34293 Montpellier Cedex 5, France
    Genes Dev 13:740-53. 1999
    ..Therefore, RSF1 may correspond to the prototypical member of a novel family of general splicing repressors that selectively antagonize the effect of SR proteins on 5' splice-site recognition...
  24. pmc A genome-wide RNA interference screen identifies a differential role of the mediator CDK8 module subunits for GATA/ RUNX-activated transcription in Drosophila
    Vanessa Gobert
    Université de Toulouse UPS, CBD Centre de Biologie du Développement, Bâtiment 4R3, 118 route de Narbonne, 31062 Toulouse, France
    Mol Cell Biol 30:2837-48. 2010
    ..More generally, we suggest that the set of conserved factors identified herein may regulate GATA/RUNX activity in mammals...
  25. pmc The Drosophila gamma-tubulin small complex subunit Dgrip84 is required for structural and functional integrity of the spindle apparatus
    Nathalie Colombié
    Centre de Recherche en Pharmacologie Santé, Unité Mixte de Recherche 2587, Centre National de la Recherche Scientifique Pierre Fabre, Institut de Sciences et Technologies du Medicament de Toulouse, 31400 Toulouse, France
    Mol Biol Cell 17:272-82. 2006
    ..The nature of a minimal gamma-tubulin complex necessary for proper microtubule organization in the metazoans is discussed...
  26. pmc Drosophila melanogaster gamma-TuRC is dispensable for targeting gamma-tubulin to the centrosome and microtubule nucleation
    Christel Verollet
    Centre de Recherche en Pharmacologie, santé, UMR 2587, Centre National de la Recherche Scientifique Pierre Fabre, Institut de Sciences et Technologies du Medicament de Toulouse, 31432 Toulouse, Cedex 4, France
    J Cell Biol 172:517-28. 2006
    ..In conclusion, gamma-TuRCs are required for assembly of fully functional spindles, but we suggest that gamma-TuSC could be targeted to the centrosomes, which is where basic microtubule assembly activities are maintained...