Research Topics
Genomes and Genes | Philippe BoucherSummaryCountry: France Publications
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Publications
Signaling through LRP1: Protection from atherosclerosis and beyondPhilippe Boucher
CNRS, UMR7175, Universite de Strasbourg, 74, route du Rhin, Illkirch F 67401, France
Biochem Pharmacol 81:1-5. 2011..Tissue-specific gene deletion studies also reveal an important contribution of LRP1 in vascular remodeling, foam cell biology, the central nervous system, and in the molecular mechanisms of atherosclerosis...
The nuclear hormone receptor PPARγ counteracts vascular calcification by inhibiting Wnt5a signalling in vascular smooth muscle cellsEstelle Woldt
CNRS, UMR 7213, University of Strasbourg, 67401 Illkirch, France
Nat Commun 3:1077. 2012..Targeting this signalling pathway may have clinical implications in the context of common complications of atherosclerosis, including coronary artery calcification and valvular sclerosis...
LRP1 controls intracellular cholesterol storage and fatty acid synthesis through modulation of Wnt signalingJerome Terrand
CNRS, UMR7175, Universite de Strasbourg, Illkirch, F 67401 France
J Biol Chem 284:381-8. 2009..These results establish LRP1 as a novel integrator of adipogenic differentiation and fat storage signals...
