Patrick Borel

Summary

Country: France

Publications

  1. ncbi Human plasma levels of vitamin E and carotenoids are associated with genetic polymorphisms in genes involved in lipid metabolism
    Patrick Borel
    INSERM, U476 Nutrition Humaine et Lipides, INRA, UMR1260, and Univ Méditerranée Aix Marseille 2, Faculte de Medecine, IPHM IFR 125, Marseille, F 13385 France
    J Nutr 137:2653-9. 2007
  2. ncbi Vegetable-borne lutein, lycopene, and beta-carotene compete for incorporation into chylomicrons, with no adverse effect on the medium-term (3-wk) plasma status of carotenoids in humans
    Viviane Tyssandier
    Unite Maladies Metaboliques et Micronutriments, INRA, Clermont Ferrand Theix, Saint Genes Champanelle, France
    Am J Clin Nutr 75:526-34. 2002
  3. ncbi Bioaccessibility of carotenoids and vitamin E from their main dietary sources
    Emmanuelle Reboul
    INSERM, 476 Nutrition Humaine et lipides, Marseille, F 13385 France
    J Agric Food Chem 54:8749-55. 2006
  4. ncbi Factors affecting intestinal absorption of highly lipophilic food microconstituents (fat-soluble vitamins, carotenoids and phytosterols)
    Patrick Borel
    Unité 476 INSERM, Faculte de Medecine, Nutrition Humaine et Lipides, Marseille, France
    Clin Chem Lab Med 41:979-94. 2003
  5. doi Comparable reduction in cholesterol absorption after two different ways of phytosterol administration in humans
    Marie Josephe Amiot
    Nutrition, Obesity and Thrombotic Risk, INRA, UMR 1260, Universite Aix Marseille, Campus Santé La Timone, 27 Boulevard Jean Moulin, 13385, Marseille Cedex 05, France
    Eur J Nutr 52:1215-22. 2013
  6. ncbi Human fasting plasma concentrations of vitamin E and carotenoids, and their association with genetic variants in apo C-III, cholesteryl ester transfer protein, hepatic lipase, intestinal fatty acid binding protein and microsomal triacylglycerol transfer p
    Patrick Borel
    INRA, UMR 1260 Nutriments Lipidiques et Prévention des Maladies Métaboliques, Marseille, France
    Br J Nutr 101:680-7. 2009
  7. doi Phytosterols can impair vitamin D intestinal absorption in vitro and in mice
    Aurélie Goncalves
    INRA, UMR 1260 Lipid Nutriments and Prevention of Metabolique Dieases, Marseille, France
    Mol Nutr Food Res 55:S303-11. 2011
  8. ncbi Enrichment of tomato paste with 6% tomato peel increases lycopene and beta-carotene bioavailability in men
    Emmanuelle Reboul
    INSERM, U476 Nutrition Humaine et Lipides, INRA, UMR 1260, Univ Méditerranée Aix Marseille 2, Marseille F 13385, France
    J Nutr 135:790-4. 2005
  9. ncbi Differential effect of dietary antioxidant classes (carotenoids, polyphenols, vitamins C and E) on lutein absorption
    Emmanuelle Reboul
    INSERM, U476, Marseille, France
    Br J Nutr 97:440-6. 2007
  10. ncbi Effects of physicochemical properties of carotenoids on their bioaccessibility, intestinal cell uptake, and blood and tissue concentrations
    Charlotte Sy
    INRA, UMR1260, Nutrition Obesity and Risk of Thrombosis, Marseille, France
    Mol Nutr Food Res 56:1385-97. 2012

Collaborators

Detail Information

Publications41

  1. ncbi Human plasma levels of vitamin E and carotenoids are associated with genetic polymorphisms in genes involved in lipid metabolism
    Patrick Borel
    INSERM, U476 Nutrition Humaine et Lipides, INRA, UMR1260, and Univ Méditerranée Aix Marseille 2, Faculte de Medecine, IPHM IFR 125, Marseille, F 13385 France
    J Nutr 137:2653-9. 2007
    ..These results suggest that genes involved in lipid metabolism influence the plasma concentrations of these fat-soluble micronutrients...
  2. ncbi Vegetable-borne lutein, lycopene, and beta-carotene compete for incorporation into chylomicrons, with no adverse effect on the medium-term (3-wk) plasma status of carotenoids in humans
    Viviane Tyssandier
    Unite Maladies Metaboliques et Micronutriments, INRA, Clermont Ferrand Theix, Saint Genes Champanelle, France
    Am J Clin Nutr 75:526-34. 2002
    ..The results of epidemiologic studies have consistently shown associations between dietary intake or plasma carotenoid status and incidence of cancers and cardiovascular and eye diseases...
  3. ncbi Bioaccessibility of carotenoids and vitamin E from their main dietary sources
    Emmanuelle Reboul
    INSERM, 476 Nutrition Humaine et lipides, Marseille, F 13385 France
    J Agric Food Chem 54:8749-55. 2006
    ..Bioaccessibility was dependent on (i) microconstituent species (lutein > beta-carotene and alpha-carotene > lycopene and alpha-tocopherol generally > gamma-tocopherol), (ii) food matrix, and (iii) food processing...
  4. ncbi Factors affecting intestinal absorption of highly lipophilic food microconstituents (fat-soluble vitamins, carotenoids and phytosterols)
    Patrick Borel
    Unité 476 INSERM, Faculte de Medecine, Nutrition Humaine et Lipides, Marseille, France
    Clin Chem Lab Med 41:979-94. 2003
    ..The available data reveal numerous gaps in the knowledge of the metabolism of HLFMs and the factors that affect their absorption. These gaps need to be filled to be able to formulate HLFMs so as to promote greater absorption efficiency...
  5. doi Comparable reduction in cholesterol absorption after two different ways of phytosterol administration in humans
    Marie Josephe Amiot
    Nutrition, Obesity and Thrombotic Risk, INRA, UMR 1260, Universite Aix Marseille, Campus Santé La Timone, 27 Boulevard Jean Moulin, 13385, Marseille Cedex 05, France
    Eur J Nutr 52:1215-22. 2013
    ..The main objective was to investigate the effects of phytosterol esters (PE) provided either as a spread (dispersed in fat) during a mixed meal or as a minidrink (micro-dispersed in liquid form) after a meal...
  6. ncbi Human fasting plasma concentrations of vitamin E and carotenoids, and their association with genetic variants in apo C-III, cholesteryl ester transfer protein, hepatic lipase, intestinal fatty acid binding protein and microsomal triacylglycerol transfer p
    Patrick Borel
    INRA, UMR 1260 Nutriments Lipidiques et Prévention des Maladies Métaboliques, Marseille, France
    Br J Nutr 101:680-7. 2009
    ..These results suggest that apo C-III, CETP and hepatic lipase play a role in determining the plasma concentrations of tocopherols while hepatic lipase and I-FABP may modulate plasma concentrations of carotenoids...
  7. doi Phytosterols can impair vitamin D intestinal absorption in vitro and in mice
    Aurélie Goncalves
    INRA, UMR 1260 Lipid Nutriments and Prevention of Metabolique Dieases, Marseille, France
    Mol Nutr Food Res 55:S303-11. 2011
    ....
  8. ncbi Enrichment of tomato paste with 6% tomato peel increases lycopene and beta-carotene bioavailability in men
    Emmanuelle Reboul
    INSERM, U476 Nutrition Humaine et Lipides, INRA, UMR 1260, Univ Méditerranée Aix Marseille 2, Marseille F 13385, France
    J Nutr 135:790-4. 2005
    ..1%, P = 0.093). Peel enrichment of tomato paste with tomato peel is an interesting option for increasing lycopene and beta-carotene intakes...
  9. ncbi Differential effect of dietary antioxidant classes (carotenoids, polyphenols, vitamins C and E) on lutein absorption
    Emmanuelle Reboul
    INSERM, U476, Marseille, France
    Br J Nutr 97:440-6. 2007
    ..Taken together, the present results suggest that lutein absorption is not markedly affected by physiological concentrations of vitamins C and E but can be impaired by carotenoids and naringenin..
  10. ncbi Effects of physicochemical properties of carotenoids on their bioaccessibility, intestinal cell uptake, and blood and tissue concentrations
    Charlotte Sy
    INRA, UMR1260, Nutrition Obesity and Risk of Thrombosis, Marseille, France
    Mol Nutr Food Res 56:1385-97. 2012
    ..g., hydrophobicity, van der Waals volume,…) on the transport of the main dietary carotenoids (β-carotene, lycopene, lutein, and astaxanthin, from their food matrix to their main storage tissues...
  11. doi Inhibition of iron-induced lipid peroxidation by newly identified bacterial carotenoids in model gastric conditions: comparison with common carotenoids
    Charlotte Sy
    INRA, UMR408, Sécurité et Qualité des Produits d Origine Végétale, F 84000 Avignon, France
    Food Funct 4:698-712. 2013
    ..Overall, carotenoids from Bacillus indicus HU36 and Bacillus firmus GB1 were found to be interesting antioxidants to fight postprandial oxidative stress in the stomach...
  12. pmc Effect of type of TAG fatty acids on lutein and zeaxanthin bioavailability
    Béatrice Gleize
    INRA, UMR1260, Research Unit in Nutrition, Obesity and Risk of Thrombosis, Faculte de Medecine, 27 Boulevard Jean Moulin, F 13385 Marseille, Cedex 5, France
    Br J Nutr 110:1-10. 2013
    ..This is due partly to the higher bioaccessibility of these xanthophylls in the smaller mixed micelles produced when SFA are incorporated into mixed micelles...
  13. ncbi The postprandial chylomicron triacylglycerol response to dietary fat in healthy male adults is significantly explained by a combination of single nucleotide polymorphisms in genes involved in triacylglycerol metabolism
    Charles Desmarchelier
    Institut National de la Recherche Agronomique INRA, Unité Mixte de Recherche UMR INRA1260, F 13005, Marseille, France INSERM, UMR_S 1062, F 13005, Marseille, France and Aix Marseille Université, Nutrition, Obésité et Risques Thrombotiques, F 13005, Marseille, France
    J Clin Endocrinol Metab 99:E484-8. 2014
    ..This is assumed to be due, at least partly, to polymorphisms in genes involved in lipid metabolism. Existing studies have focused on single nucleotide polymorphisms (SNPs), resulting in only a low explained variability...
  14. doi CD36 is involved in lycopene and lutein uptake by adipocytes and adipose tissue cultures
    Myriam Moussa
    INRA, UMR1260 Nutriments Lipidiques et Prevention des Maladies Metaboliques, Marseille, France
    Mol Nutr Food Res 55:578-84. 2011
    ..However, nothing is known regarding the uptake of carotenoids by adipocytes. Thus, our study explored the mechanism by which lycopene and lutein, two major human plasma carotenoids, are transported...
  15. doi CD36 and SR-BI are involved in cellular uptake of provitamin A carotenoids by Caco-2 and HEK cells, and some of their genetic variants are associated with plasma concentrations of these micronutrients in humans
    Patrick Borel
    INRA, UMR1260 Nutrition, Obesity and Risk of Thrombosis, Marseille, France
    J Nutr 143:448-56. 2013
    ..In conclusion, SR-BI and CD36 are involved in cellular uptake of provitamin A carotenoids, and genetic variations in their encoding genes may modulate plasma concentrations of provitamin A carotenoids at a population level...
  16. pmc Phytosterol ester processing in the small intestine: impact on cholesterol availability for absorption and chylomicron cholesterol incorporation in healthy humans
    Marie Josephe Amiot
    INRA, UMR1260, Nutriments Lipidiques et Prévention des Maladies Métaboliques, Marseille, F 13385 France
    J Lipid Res 52:1256-64. 2011
    ..control; P < 0.0001). The present data show that addition of PE to a meal does not alter TG hydrolysis but displaces cholesterol from the intestinal aqueous phase and lowers chylomicron cholesterol occurrence in humans...
  17. doi The distribution and relative hydrolysis of tocopheryl acetate in the different matrices coexisting in the lumen of the small intestine during digestion could explain its low bioavailability
    Charles Desmarchelier
    INRA, UMR INRA1260, Marseille, France
    Mol Nutr Food Res 57:1237-45. 2013
    ..Its absorption efficiency is low compared to that of triacylglycerols. The aim of this work was thus to study the fate of TAC during digestion...
  18. ncbi Vitamin E decreases endogenous cholesterol synthesis and apo-AI-mediated cholesterol secretion in Caco-2 cells
    Jean Francois Landrier
    INRA, UMR1260 Nutriments Lipidiques et Prevention des Maladies Metaboliques, Marseille, F 13385 France
    J Nutr Biochem 21:1207-13. 2010
    ..The outcome is a decrease of LXR activity, resulting in down-regulation of ABCA1. These data reinforce the effect of α- and γ-tocopherol on cholesterol metabolism via gene expression regulation...
  19. doi Proteins involved in uptake, intracellular transport and basolateral secretion of fat-soluble vitamins and carotenoids by mammalian enterocytes
    Emmanuelle Reboul
    INRA, UMR1260 Lipid Nutrients and Prevention of Metabolic Diseases, F 13385 Marseille Cedex 5, France
    Prog Lipid Res 50:388-402. 2011
    ..Indeed, these drugs may also interfere with lipid vitamin uptake. A better understanding of the molecular mechanisms involved in fat-soluble vitamin and carotenoid absorption is a priority to better optimize their bioavailability...
  20. doi ATP-binding cassette transporter A1 is significantly involved in the intestinal absorption of alpha- and gamma-tocopherol but not in that of retinyl palmitate in mice
    Emmanuelle Reboul
    INRA, UMR1260, Nutriments Lipidiques et Prévention des Maladies Métaboliques, INSERM, U476, Université Aix Marseille 1, Université Aix Marseille 2, Faculte de Medecine, IPHM IFR 125, Marseille, France
    Am J Clin Nutr 89:177-84. 2009
    ..It has long been assumed that newly absorbed vitamin A and E enter the body only via enterocyte-produced chylomicrons. However, recent results in cell cultures have shown that a fraction of alpha-tocopherol is secreted with intestinal HDL...
  21. pmc Lutein transport by Caco-2 TC-7 cells occurs partly by a facilitated process involving the scavenger receptor class B type I (SR-BI)
    Emmanuelle Reboul
    UMR 476 INSERM, Faculte de Medecine, 27 Bd Jean Moulin, 13385 Marseille Cedex 5, France
    Biochem J 387:455-61. 2005
    ..30% and 57% respectively). Overall, these results indicate that lutein absorption is, at least partly, protein-mediated and that some lutein is taken up through SR-BI...
  22. doi Genetic variants in BCMO1 and CD36 are associated with plasma lutein concentrations and macular pigment optical density in humans
    Patrick Borel
    INRA, UMR1260 Nutriments Lipidiques et Prevention des Maladies Metaboliques, F 13385 Marseille, France
    Ann Med 43:47-59. 2011
    ..Lutein is recovered at high concentration in the human macula lutea. Recent studies suggest that this micronutrient might be implicated in prevention of age-related macular degeneration...
  23. doi Iron-induced oxidation of (all-E)-β-carotene under model gastric conditions: kinetics, products, and mechanism
    Charlotte Sy
    INRA, UMR408 Sécurité et Qualité des Produits d Origine Végétale, F 84000 Avignon, France
    Free Radic Biol Med 63:195-206. 2013
    ....
  24. doi Vitamin D intestinal absorption is not a simple passive diffusion: evidences for involvement of cholesterol transporters
    Emmanuelle Reboul
    INRA, UMR1260 Nutriments Lipidiques et Prevention des Maladies Metaboliques, Marseille, France
    Mol Nutr Food Res 55:691-702. 2011
    ..It is assumed that vitamin D is absorbed by passive diffusion. However, since cholecalciferol (vitamin D(3) ) and cholesterol display similar structures, we hypothesized that common absorption pathways may exist...
  25. doi Comparison of different vehicles to study the effect of tocopherols on gene expression in intestinal cells
    Jean Francois Landrier
    INRA, UMR1260 Nutriments Lipidiques et Prevention des Maladies Metaboliques, Marseille, France
    Free Radic Res 42:523-30. 2008
    ..This study establishes mixed micelles as the best vehicle to deliver tocopherols to intestinal cell monolayers in culture...
  26. ncbi Adiponectin expression is induced by vitamin E via a peroxisome proliferator-activated receptor gamma-dependent mechanism
    Jean Francois Landrier
    Unite Mixte de Recherche, Faculte de Medecine, 1260 Institut National de la Recherche Agronomique, Marseille, France
    Endocrinology 150:5318-25. 2009
    ..The induction of adiponectin via an original molecular mechanism could be considered as the basis for the beneficial effect of vitamin E on insulin sensitivity...
  27. ncbi β-lactoglobulin as a vector for β-carotene food fortification
    Azza Mensi
    Biopolymères Interactions Assemblages, INRA, UR 1268, F 44316 Nantes, France
    J Agric Food Chem 62:5916-24. 2014
    ..Overall, we showed that β-Lg would be a good vector for β-carotene food fortification. ..
  28. ncbi Pancreatic lipase and pancreatic lipase-related protein 2, but not pancreatic lipase-related protein 1, hydrolyze retinyl palmitate in physiological conditions
    Emmanuelle Reboul
    INSERM 476, Faculte de Medecine, 27 Boulevard Jean Moulin, Marseille F 13385 Cedex 5, France
    Biochim Biophys Acta 1761:4-10. 2006
    ....
  29. doi Genetic variations involved in interindividual variability in carotenoid status
    Patrick Borel
    INRA, UMR1260 Lipid Nutrients and Prevention of Metabolic Diseases, Marseille, France
    Mol Nutr Food Res 56:228-40. 2012
    ..g. copy number variants and epigenetic modifications, can modulate carotenoid status. One potential application of such research could be personalized dietary guidelines for carotenoids according to individual genetic characteristics...
  30. ncbi Short-term supplementation with lutein affects biomarkers of lutein status similarly in young and elderly subjects
    Nicolas Cardinault
    Unite Maladies Metaboliques et Micronutriments, INRA, Clermont Ferrand Theix, 63122, Saint Genes Champanelle, France
    Exp Gerontol 38:573-82. 2003
    ..These results suggest that there is no major effect of age on lutein status in healthy subjects...
  31. ncbi Amounts and types of fatty acids in meals affect the pattern of retinoids secreted in human chylomicrons after a high-dose preformed vitamin A intake
    Patrick Sauvant
    Unite Maladies Metaboliques et Micronutriments, INRA, Clermont Ferrand Theix, Saint Genes Champanelle, France
    Metabolism 52:514-9. 2003
    ..If a high dose of preformed vitamin A is ingested with a fat-free meal, a significant proportion of retinol is not esterified, owing to the lack of fatty acids for ARAT, which explains the appearance of free retinol in chylomicrons...
  32. ncbi Carotenoids, mostly the xanthophylls, exchange between plasma lipoproteins
    Viviane Tyssandier
    Unite Maladies Metaboliques et Micronutriments, INRA, Clermont Ferrand Theix, 63122 Saint Genes Champanelle, France
    Int J Vitam Nutr Res 72:300-8. 2002
    ..We conclude that carotenoids, chiefly the xanthophylls, exchange between lipoproteins. The transfer depends on plasma factor(s) sensitive to CETP and/or LCAT inhibitors...
  33. doi Polymorphisms in the CD36/FAT gene are associated with plasma vitamin E concentrations in humans
    Sophie Lecompte
    INSERM, U744, Institut Pasteur de Lille, Universite Lille Nord de France, Lille, France
    Am J Clin Nutr 93:644-51. 2011
    ..CD36 (cluster of differentiation 36), a class B scavenger receptor, might be involved in tissue vitamin E uptake and thus would influence blood vitamin E concentrations...
  34. ncbi Lycopene absorption in human intestinal cells and in mice involves scavenger receptor class B type I but not Niemann-Pick C1-like 1
    Myriam Moussa
    Institut National de la Recherche Agronomique, UMR1260 Nutriments Lipidiques et Prevention des Maladies Metaboliques, F 13385 Marseille, France
    J Nutr 138:1432-6. 2008
    ..Thus, the present data show that lycopene absorption is, at least in part, mediated by SR-BI but not by NPC1L1...
  35. ncbi Comparison of the postprandial chylomicron carotenoid responses in young and older subjects
    Nicolas Cardinault
    Unité Maladies Métaboliques et Micronutriments UMMM, Centre INRA de Clermont Ferrand Theix, 63122, Saint Genes Champanelle
    Eur J Nutr 42:315-23. 2003
    ..Epidemiological studies consistently associated high plasma carotenoids status with reduced age-related diseases. However, the data concerning the bioavailability of carotenoids in the elderly are scarce...
  36. ncbi Butter differs from olive oil and sunflower oil in its effects on postprandial lipemia and triacylglycerol-rich lipoproteins after single mixed meals in healthy young men
    Nadia Mekki
    Unité 476 Institut National de la Santé et de la Recherche Médicale, Human Nutrition and Lipids, National Institute of Health and Medical Research, Universite de la Mediterranee, 13009 Marseille, France
    J Nutr 132:3642-9. 2002
    ..We conclude that butter results in lower postprandial lipemia and chylomicron accumulation in the circulation of young men than olive or sunflower oils after consumption of a single mixed meal...
  37. ncbi Processing of vegetable-borne carotenoids in the human stomach and duodenum
    Viviane Tyssandier
    Unite Maladies Metaboliques et Micronutriments, Institut National de la Recherche Agronomique, Clermont Ferrand Theix, 63122 Saint Genes Champanelle, France
    Am J Physiol Gastrointest Liver Physiol 284:G913-23. 2003
    ..Lycopene is less efficiently transferred to micelles than beta-carotene and lutein. The very small transfer of carotenoids from their vegetable matrices to micelles explains the poor bioavailability of these phytomicroconstituents...
  38. ncbi Effect of tomato product consumption on the plasma status of antioxidant microconstituents and on the plasma total antioxidant capacity in healthy subjects
    Viviane Tyssandier
    Unité des Maladies Métaboliques et Micronutriments, centre INRA National Institute for Agronomic Research de Clermont Ferrand Theix, Saint Genes Champanelle, France
    J Am Coll Nutr 23:148-56. 2004
    ....
  39. ncbi Influence of organic versus conventional agricultural practice on the antioxidant microconstituent content of tomatoes and derived purees; consequences on antioxidant plasma status in humans
    Catherine Caris-Veyrat
    UMR A408 INRA Université d Avignon et des Pays du Vaucluse, Sécurité et Qualité des Produits d Origine Végétale, INRA Domaine Saint Paul, Site Agroparc, 84914 Avignon Cedex 9, France
    J Agric Food Chem 52:6503-9. 2004
    ....
  40. pmc Scavenger receptor class B type I (SR-BI) is involved in vitamin E transport across the enterocyte
    Emmanuelle Reboul
    INSERM U476, 27 Boulevard Jean Moulin, 1260 Institut National de la Recherche Agronomique INRA, Université AixMarseille, and Institut de Physiopathologie Humaine de Marseille IPMH, Marseille F 13385, France
    J Biol Chem 281:4739-45. 2006
    ..7-fold higher in mice overexpressing SR-BI than in wild-type mice (p < 0.05). The present data show for the first time that vitamin E intestinal absorption is, at least in part, mediated by SR-BI...
  41. ncbi Beta-cryptoxanthin from citrus juices: assessment of bioaccessibility using an in vitro digestion/Caco-2 cell culture model
    Claudie Dhuique-Mayer
    Centre de Cooperation Internationale en Recherche Agronomique pour le Developpement CIRAD, UR 24, Tropical food quality, TA50 04, 34398 Montpellier Cedex 5, France
    Br J Nutr 97:883-90. 2007
    ..3 (SD 1.8), 3.9 (SD 1.3), and 0.7 (SD 0.08) % respectively. These results showed a preferential uptake by Caco-2 cells of beta-carotene and free beta-CX compared with the two esters of beta-CX...