Philippe Bonnin

Summary

Country: France

Publications

  1. ncbi request reprint Ultrasonic assessment of hepatic blood flow as a marker of mouse hepatocarcinoma
    Philippe Bonnin
    Cardiovascular Research Center, INSERM, Lariboisiere, INSERM U689, Paris, France
    Ultrasound Med Biol 33:561-70. 2007
  2. doi request reprint Anti-TNFα therapy early improves hemodynamics in local intestinal and extraintestinal circulations in active Crohn's disease
    Philippe Bonnin
    Univ Paris Diderot, Sorbonne Paris Cité, AP HP, Hopital Lariboisiere, Physiologie Clinique Explorations Fonctionnelles, 75010, Paris, France
    J Crohns Colitis 7:451-9. 2013
  3. doi request reprint Ultrasound assessment of short-term ocular vascular effects of intravitreal injection of bevacizumab (Avastin(®) ) in neovascular age-related macular degeneration
    Philippe Bonnin
    Lariboisiere Hospital, University of Paris, Paris, France
    Acta Ophthalmol 88:641-5. 2010
  4. doi request reprint Ultrasonic assessment of cerebral blood flow changes during ischemia-reperfusion in 7-day-old rats
    Philippe Bonnin
    AP HP, Hopital Lariboisiere, Physiologie Explorations Fonctionnelles, Universite Denis Diderot Paris 7, Paris, France
    Ultrasound Med Biol 34:913-22. 2008
  5. doi request reprint Ultrasound imaging of renal vaso-occlusive events in transgenic sickle mice exposed to hypoxic stress
    Philippe Bonnin
    Centre de Recherche Cardiovasculaire Inserm Lariboisiere, INSERM U689, Paris, France
    Ultrasound Med Biol 34:1076-84. 2008
  6. doi request reprint Sildenafil mediates blood-flow redistribution and neuroprotection after neonatal hypoxia-ischemia
    Christiane Charriaut-Marlangue
    From the Univ Paris Diderot, Sorbonne Paris Cité, INSERM U1141, Paris, France C C M, T N, A P D, P L L, Z C, J P, T B, O B PremUP Foundation, Paris, France C C M, P L L, J P, O B Univ Paris Diderot, Sorbonne Paris Cité, AP HP, Hopital Lariboisiere, Physiologie Clinique Explorations Fonctionnelles, Paris, France P B Univ Paris Diderot, Sorbonne Paris Cité, INSERM, U965, Paris, France P B UPMC, Paris Universitas, AP HP, Hopital Armand Trousseau, Service de Reanimation, Pédiatrique, Paris, France S R and Univ Paris Diderot, Takayama
    Stroke 45:850-6. 2014
  7. ncbi request reprint Nitric oxide signaling in the brain: a new target for inhaled nitric oxide?
    Christiane Charriaut-Marlangue
    Paris Diderot University, Sorbonne Paris Cité, INSERM U676, Paris, France PremUP Foundation
    Ann Neurol 73:442-8. 2013
  8. doi request reprint Impact of intracranial blood-flow redistribution on stroke size during ischemia-reperfusion in 7-day-old rats
    Philippe Bonnin
    AP HP, Hopital Lariboisiere, Physiologie Explorations Fonctionnelles, Universite Denis Diderot Paris7, France
    J Neurosci Methods 198:103-9. 2011
  9. pmc Dynamic spatio-temporal imaging of early reflow in a neonatal rat stroke model
    Pierre Louis Leger
    Sorbonne Paris Cité, INSERM U676, Univ Paris Diderot, Paris, France
    J Cereb Blood Flow Metab 33:137-45. 2013
  10. ncbi request reprint Dual action of NO synthases on blood flow and infarct volume consecutive to neonatal focal cerebral ischemia
    Philippe Bonnin
    Univ Paris Diderot, Sorbonne Paris Cité, AP HP, Hopital Lariboisiere, Physiologie Clinique Explorations Fonctionnelles, 75010 Paris, France
    Exp Neurol 236:50-7. 2012

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Ultrasonic assessment of hepatic blood flow as a marker of mouse hepatocarcinoma
    Philippe Bonnin
    Cardiovascular Research Center, INSERM, Lariboisiere, INSERM U689, Paris, France
    Ultrasound Med Biol 33:561-70. 2007
    ....
  2. doi request reprint Anti-TNFα therapy early improves hemodynamics in local intestinal and extraintestinal circulations in active Crohn's disease
    Philippe Bonnin
    Univ Paris Diderot, Sorbonne Paris Cité, AP HP, Hopital Lariboisiere, Physiologie Clinique Explorations Fonctionnelles, 75010, Paris, France
    J Crohns Colitis 7:451-9. 2013
    ..We prospectively studied hemodynamics in feeding arteries of bowel and eyes before and 2 weeks after treatment induction with anti-TNFα...
  3. doi request reprint Ultrasound assessment of short-term ocular vascular effects of intravitreal injection of bevacizumab (Avastin(®) ) in neovascular age-related macular degeneration
    Philippe Bonnin
    Lariboisiere Hospital, University of Paris, Paris, France
    Acta Ophthalmol 88:641-5. 2010
    ..However, evolution to retinal atrophy cannot be ruled out and it may be useful to assess the effects of antiangiogenic therapy on retinal and choroidal circulation...
  4. doi request reprint Ultrasonic assessment of cerebral blood flow changes during ischemia-reperfusion in 7-day-old rats
    Philippe Bonnin
    AP HP, Hopital Lariboisiere, Physiologie Explorations Fonctionnelles, Universite Denis Diderot Paris 7, Paris, France
    Ultrasound Med Biol 34:913-22. 2008
    ..In preclinical studies, this method could help to identify what can be assigned to a neuroprotective treatment and what depends on changes in cerebral blood flow supply...
  5. doi request reprint Ultrasound imaging of renal vaso-occlusive events in transgenic sickle mice exposed to hypoxic stress
    Philippe Bonnin
    Centre de Recherche Cardiovasculaire Inserm Lariboisiere, INSERM U689, Paris, France
    Ultrasound Med Biol 34:1076-84. 2008
    ..Thus, ultrasound imaging of the renal artery in mouse is a powerful, noninvasive, easy-to-repeat method to evidence circulatory changes in murine models of vascular renal human diseases...
  6. doi request reprint Sildenafil mediates blood-flow redistribution and neuroprotection after neonatal hypoxia-ischemia
    Christiane Charriaut-Marlangue
    From the Univ Paris Diderot, Sorbonne Paris Cité, INSERM U1141, Paris, France C C M, T N, A P D, P L L, Z C, J P, T B, O B PremUP Foundation, Paris, France C C M, P L L, J P, O B Univ Paris Diderot, Sorbonne Paris Cité, AP HP, Hopital Lariboisiere, Physiologie Clinique Explorations Fonctionnelles, Paris, France P B Univ Paris Diderot, Sorbonne Paris Cité, INSERM, U965, Paris, France P B UPMC, Paris Universitas, AP HP, Hopital Armand Trousseau, Service de Reanimation, Pédiatrique, Paris, France S R and Univ Paris Diderot, Takayama
    Stroke 45:850-6. 2014
    ..Our objective was to examine whether boosting NO-cGMP signaling using sildenafil citrate, a phosphodiesterase-type 5 inhibitor, could modify cerebral blood flow and reduce lesions in the developing brain...
  7. ncbi request reprint Nitric oxide signaling in the brain: a new target for inhaled nitric oxide?
    Christiane Charriaut-Marlangue
    Paris Diderot University, Sorbonne Paris Cité, INSERM U676, Paris, France PremUP Foundation
    Ann Neurol 73:442-8. 2013
    ..This review provides new insights into the short- and long-term effects of endogenous and exogenous NO in brain injury...
  8. doi request reprint Impact of intracranial blood-flow redistribution on stroke size during ischemia-reperfusion in 7-day-old rats
    Philippe Bonnin
    AP HP, Hopital Lariboisiere, Physiologie Explorations Fonctionnelles, Universite Denis Diderot Paris7, France
    J Neurosci Methods 198:103-9. 2011
    ..Ultrasound imaging can evidence the establishment or not of the cerebral collateral recruitment, leading to the presence or absence of a lesion. This novel approach should greatly help preclinical studies to reduce animal variability...
  9. pmc Dynamic spatio-temporal imaging of early reflow in a neonatal rat stroke model
    Pierre Louis Leger
    Sorbonne Paris Cité, INSERM U676, Univ Paris Diderot, Paris, France
    J Cereb Blood Flow Metab 33:137-45. 2013
    ....
  10. ncbi request reprint Dual action of NO synthases on blood flow and infarct volume consecutive to neonatal focal cerebral ischemia
    Philippe Bonnin
    Univ Paris Diderot, Sorbonne Paris Cité, AP HP, Hopital Lariboisiere, Physiologie Clinique Explorations Fonctionnelles, 75010 Paris, France
    Exp Neurol 236:50-7. 2012
    ..In conclusion, both nNOS and eNOS appear to play a key role in modulating arterial blood flow during ischemia mainly in male pups with subsequent modifications in infarct lesion...
  11. doi request reprint Inhaled nitric oxide reduces brain damage by collateral recruitment in a neonatal stroke model
    Christiane Charriaut-Marlangue
    University Paris Diderot, Sorbonne Paris Cité, INSERM U676 and NICU, Robert Debré Children s Hospital, 48 Bd Serurier 75019 Paris, France
    Stroke 43:3078-84. 2012
    ..Our objective was to examine whether iNO could modify cerebral blood flow during ischemia-reperfusion and reduce lesions in the developing brain...
  12. doi request reprint Angiotensinogen delays angiogenesis and tumor growth of hepatocarcinoma in transgenic mice
    Francois Vincent
    Chaire de Médecine Expérimentale, Inserm U833, College de France, Paris, France
    Cancer Res 69:2853-60. 2009
    ..Overexpression of human angiotensinogen decreases angiogenesis, and prevents tumor sinusoids from remodeling and arterialization, thus delaying tumor progression in vivo...
  13. doi request reprint Chronic hypoxia-induced angiogenesis normalizes blood pressure in spontaneously hypertensive rats
    Jose Vilar
    Cardiovascular Research Center, Institut National de la Santé et de la Recherche Médicale Lariboisière Unit 689, and Université Paris 7 Denis Diderot, Hopital Lariboisiere, Paris, France
    Circ Res 103:761-9. 2008
    ....
  14. pmc Ischemic postconditioning fails to protect against neonatal cerebral stroke
    Pierre Louis Leger
    Univ Paris Diderot, Sorbonne Paris Cité, INSERM, U676, Paris, France
    PLoS ONE 7:e49695. 2012
    ..The absence of acute hyperemia during early CCA re-flow, and the lack of NO-dependent vasoreactivity in P7 rat brain could in part explain the inefficiency of ischemic postconditioning after ischemia-reperfusion...
  15. pmc Endothelin receptor antagonism prevents hypoxia-induced mortality and morbidity in a mouse model of sickle-cell disease
    Nathalie Sabaa
    Cardiovascular Research Center Lariboisiere, INSERM U689, Paris, France
    J Clin Invest 118:1924-33. 2008
    ..These findings in mice suggest that ETRA could be a potential new therapy for SCD, as it may prevent acute VOC and limit organ damage in sickle-cell patients...
  16. doi request reprint Noninvasive assessment of endothelial function in the skin microcirculation
    Haythem Debbabi
    Department of Non Invasive Investigations, Cardiovascular Research Centre, PARCC Inserm U970, Lariboisiere Hospital, Paris, France
    Am J Hypertens 23:541-6. 2010
    ..The aim of this study was to determine whether the laser Doppler response of skin microcirculation to acetylcholine, reflects that of conduit artery assessed by brachial artery flow-mediated dilation (FMD)...
  17. doi request reprint Neuropilin-1 is upregulated in hepatocellular carcinoma and contributes to tumour growth and vascular remodelling
    Mathieu Berge
    Institut des Vaisseaux et du Sang, Hopital Lariboisiere, Universite Paris 7, France
    J Hepatol 55:866-75. 2011
    ..Recent studies revealed an important role of NRP1 in angiogenesis and malignant progression of many cancers. The role of NRP1 in the development of hepatocellular carcinoma (HCC) is not completely understood...
  18. doi request reprint Serotonin and angiotensin receptors in cardiac fibroblasts coregulate adrenergic-dependent cardiac hypertrophy
    Fabrice Jaffré
    Institut National de Santé et de Recherche Médicale, U839, Paris, France
    Circ Res 104:113-23. 2009
    ..Accordingly, antagonists of 5-HT(2B) receptors might represent novel therapeutics for sympathetic overstimulation-dependent heart failure...
  19. doi request reprint Inhaled NO prevents hyperoxia-induced white matter damage in neonatal rats
    Hoa Pham
    INSERM, UMR 676, 75019 Paris, France Université Paris Diderot, UFR de Médecine Denis Diderot, Sorbonne Paris Cité, 75010 Paris, France PremUP Foundation, 75014 Paris, France
    Exp Neurol 252:114-23. 2014
    ..These findings suggest that iNO exposure at low doses is specifically neuroprotective in an animal model combining injuries of the developing lung and brain that mimicked BPD and WMD in preterm infants...
  20. doi request reprint Effects of blood pressure control with perindopril/indapamide on the microcirculation in hypertensive patients
    Haytem Debbabi
    Department of Non Invasive Investigations, PARCC Inserm U, INSERM U, Lariboisiere Hospital, AP HP, University Paris Diderot, France
    Am J Hypertens 23:1136-43. 2010
    ....
  21. pmc Unilateral blood flow decrease induces bilateral and symmetric responses in the immature brain
    Sonia Villapol
    UMR Centre de la Recherche Scientifique, Equipe Hypoxie et Ischemie du Cerveau en Development, Paris, France
    Am J Pathol 175:2111-20. 2009
    ..Additionally, the opposite healthy hemisphere is altered due to the injury and thus should not be used as an internal control...
  22. pmc Small interfering RNAs induce target-independent inhibition of tumor growth and vasculature remodeling in a mouse model of hepatocellular carcinoma
    Mathieu Berge
    Institut des Vaisseaux et du Sang, INSERM U965 Equipe Labellisée LIGUE 2009, Universite Paris 7, Paris, France
    Am J Pathol 177:3192-201. 2010
    ..Our results suggest that synthetic siRNAs inhibit target-independently HCC growth and angiogenesis through the activation of the innate interferon response and by directly inhibiting endothelial cell function...
  23. pmc Lutheran/basal cell adhesion molecule accelerates progression of crescentic glomerulonephritis in mice
    Jin Huang
    1 Paris Cardiovascular Research Centre, Institut National de la Sante et de la Recherche Medicale INSERM, Paris, France 2 Université Paris Descartes, Sorbonne Paris Cité, Paris, France
    Kidney Int 85:1123-36. 2014
    ..Thus, Lu/BCAM may have a critical role in facilitating the accumulation of monocytes and macrophages, thereby exacerbating renal injury. ..
  24. pmc B lymphocytes trigger monocyte mobilization and impair heart function after acute myocardial infarction
    Yasmine Zouggari
    1 Institut National de la Santé et de la Recherche Médicale INSERM, Unit 970, Paris Cardiovascular Research Center, Paris, France 2 Université Paris Descartes, Paris, France 3
    Nat Med 19:1273-80. 2013
    ..This work identifies a crucial interaction between mature B lymphocytes and monocytes after acute myocardial ischemia and identifies new therapeutic targets for acute myocardial infarction. ..
  25. ncbi request reprint Flow-mediated vasodilatation of carotid and brachial arteries in healthy subjects and in lacunar stroke patients
    Philippa C Lavallee
    Department of Neurology and Stroke Centre, Bichat University Hospital and Medical School, Paris, France
    Ultrasound Med Biol 32:1165-9. 2006
    ..CCA vasodilatation induced by CO(2) inhalation and NTG administration can be measured. The strong negative correlation between CCA- and BA-FMVD suggests that there could be different mechanisms of vasodilatation...
  26. ncbi request reprint Cardiac and renal effects of levosimendan, arginine vasopressin, and norepinephrine in lipopolysaccharide-treated rabbits
    Valerie Faivre
    Department of Anesthesiology and Critical Care Medicine, Institut Fédératif de Recherche 06, Paris, France
    Anesthesiology 103:514-21. 2005
    ..The aim of the current study was to assess, invasively and noninvasively, whether levosimendan, arginine vasopressin, and norepinephrine, either alone or combined, may modify sepsis-induced myocardial dysfunction and renal hemodynamics...
  27. ncbi request reprint Ultrasound assessment of ocular vascular effects of repeated intravitreal injections of ranibizumab for wet age-related macular degeneration
    Philippe Bonnin
    Sorbonne Paris Cité, AP HP, Lariboisiere Hospital, Department of Clinical Physiology Functional Investigations, Paris Diderot University, Paris, France Sorbonne Paris Cite, INSERM, U965, Paris Diderot University, Lariboisiere Hospital, Paris, France
    Acta Ophthalmol 92:e382-7. 2014
    ..5 mg; 0.05 ml) on retrobulbar blood flow velocities (BFVs) using ultrasound imaging quantification in twenty patients with exudative age-related macular degeneration treated for 6 months...
  28. ncbi request reprint Orthotopic animal model of pseudomyxoma peritonei: An in vivo model to test anti-angiogenic drug effects
    Anthony Dohan
    INSERM U965, C A R T Carcinomatosis Angiogenesis and Translational Research, Lariboisiere Hospital, Paris Diderot University, Sorbonne Paris Cité, AP HP, Paris, France Department of Body and Interventional Imaging, Lariboisiere Hospital, Paris Diderot University, Sorbonne Paris Cité, Assistance Publique Hopitaux de Paris, Paris, France Electronic address
    Am J Pathol 184:1920-9. 2014
    ..Our murine model allows researchers to actually bench test and evaluate, in preclinical studies, the efficacy of new therapeutic strategies and anti-angiogenic therapies...
  29. ncbi request reprint Tumor and non-tumor liver angiogenesis is traced and evaluated by hepatic arterial ultrasound in murine models
    Clarisse Eveno
    Universite Paris Diderot, Sorbonne Paris Cité, INSERM, UMR S 965, Paris, France
    Ultrasound Med Biol 38:1195-204. 2012
    ..1 ± 1.8 and 17.5 ± 2.4 cm s(-1), respectively, (p < 0.01) then returned to baseline as liver volume. Duplex Doppler ultrasonography reliably assesses normal or tumor angiogenesis and may provide follow-up functional evaluation...
  30. pmc TGF-beta activity protects against inflammatory aortic aneurysm progression and complications in angiotensin II-infused mice
    Yu Wang
    INSERM U970, Paris Cardiovascular Research Center, Université Paris Descartes and Assistance Publique Hôpitaux de Paris, Paris, France
    J Clin Invest 120:422-32. 2010
    ..These results clearly identify a critical role for TGF-beta in the taming of the innate immune response and the preservation of vessel integrity in C57BL/6 mice, which contrasts with its reported pathogenic role in Marfan syndrome...
  31. ncbi request reprint Increasing maternal blood pressure with ephedrine increases uterine artery blood flow velocity during uterine contraction
    Laurent Ducros
    Department of Anesthesiology and Intensive Care, Centre Hospitalier Universitaire Lariboisière, Paris, France
    Anesthesiology 96:612-6. 2002
    ..The purpose of the study was to assess the effects of ephedrine on uterine artery velocities and resistance index using the Doppler technique during the active phase of labor...
  32. doi request reprint Transcranial duplex sonography for monitoring circle of Willis artery occlusion in a rat embolic stroke model
    Bertrand Lapergue
    INSERM, U698, Hopital X Bichat, Universite Denis Diderot, Paris 7, Paris, France
    J Neurosci Methods 197:289-96. 2011
    ....
  33. doi request reprint Erythrocyte microparticles can induce kidney vaso-occlusions in a murine model of sickle cell disease
    Stéphane M Camus
    Paris Center for Cardiovascular Research, INSERM UMR s 970, Hopital Europeen Georges Pompidou, et Université Paris Descartes, Sorbonne Paris Cité, Paris, France
    Blood 120:5050-8. 2012
    ..These MPs induce endothelial injury and facilitate acute vaso-occlusive events in transgenic SAD mice. This work supports a novel concept that toxic erythrocyte MPs may connect sickle cell anemia to vascular disease...
  34. doi request reprint Protection against myocardial infarction and no-reflow through preservation of vascular integrity by angiopoietin-like 4
    Ariane Galaup
    College de France, Center for Interdisciplinary Research in Biology, 11 place Marcelin Berthelot, Paris, F 75005, France
    Circulation 125:140-9. 2012
    ..Angiopoietins are pivotal modulators of cell-cell junctions and vascular integrity. We hypothesized that hypoxic induction of angiopoietin-like protein 4 (ANGPTL4) might modulate vascular damage, infarct size, and no-reflow during AMI...
  35. doi request reprint Systemic inflammation disrupts the developmental program of white matter
    Geraldine Favrais
    INSERM U676, Denis Diderot Faculty of Medicine, University of Paris 7, Paris, France
    Ann Neurol 70:550-65. 2011
    ..The goal of the present study was to test the hypothesis that moderate systemic inflammation is sufficient to alter white matter development...
  36. doi request reprint Maternal serotonin influences cardiac function in adult offspring
    Cécile Fligny
    Unité Mixte de Recherche 7091 Centre National de la Recherche Scientifique Université Pierre et Marie Curie, Laboratoire de Genetique Moleculaire de la Neurotransmission et des Processus Neurodegeneratifs, Hopital de la Pitie Salpetriere, Paris, France
    FASEB J 22:2340-9. 2008
    ..Thus, plasma 5-HT concentration may be a useful index of heart failure. These findings show that cardiac function, through the plasma 5-HT concentration, is influenced by the maternal serotonergic status...
  37. ncbi request reprint The effects of a polymerized bovine-derived hemoglobin solution in a rabbit model of arterial thrombosis and bleeding
    Emmanuel Marret
    Departments of Anesthesiology and Critical Care and Emergency Medicine and Surgery, Hopital Pitie Salpetriere, Paris, France
    Anesth Analg 98:604-10, table of contents. 2004
    ..IMPLICATIONS: In a rabbit thrombosis and hemorrhagic model, a polymerized bovine-derived hemoglobin solution and a gelatin solution infusion decreased arterial thrombosis and lengthened bleeding time...
  38. ncbi request reprint Clinical and hemodynamic responses to balloon test occlusion of the straight sinus: technical case report
    Emmanuel Houdart
    Department of Neuroradiology and Therapeutic Angiography, Hĵpital Lariboisière, Paris, France
    Neurosurgery 51:254-6; discussion 256-7. 2002
    ..We describe a patient with a falcine meningioma who underwent endovascular balloon test occlusion of the straight sinus before surgical resection...
  39. ncbi request reprint Recombinant activated factor VII decreases bleeding without increasing arterial thrombosis in rabbits
    Maurizio Fattorutto
    Departement d Anesthesie Reanimation, Hopital Avicenne, 125 route de Stalingrad, 93009 Bobigny Cedex, France
    Can J Anaesth 51:672-9. 2004
    ..To compare the effects of recombinant activated factor VII (rFVIIa) and platelet-rich plasma (PRP) in an experimental model of bleeding and arterial thrombosis...