R Bonnet

Summary

Country: France

Publications

  1. pmc Diversity of TEM mutants in Proteus mirabilis
    R Bonnet
    Laboratoire de Bacteriologie, Faculte de Medecine, 63001 Clermont Ferrand cedex, France
    Antimicrob Agents Chemother 43:2671-7. 1999
  2. pmc Growing group of extended-spectrum beta-lactamases: the CTX-M enzymes
    R Bonnet
    Laboratoire de Bacteriologie, Faculte de Medecine, 63001 Clermont Ferrand cedex, France
    Antimicrob Agents Chemother 48:1-14. 2004
  3. ncbi request reprint Effect of D240G substitution in a novel ESBL CTX-M-27
    R Bonnet
    Laboratoire de Bacteriologie, Faculte de Medecine, Service de Bacteriologie Virologie, 28 Place Henri Dunant, 63001 Clermont Ferrand cedex, France
    J Antimicrob Chemother 52:29-35. 2003
  4. pmc Inducible AmpC beta-lactamase of a new member Enterobacteriaceae
    Richard Bonnet
    Laboratoire de Bacteriologie, Faculte de Medecine, 63001 Clermont Ferrand cedex, France
    Antimicrob Agents Chemother 46:3316-9. 2002
  5. pmc Chromosome-encoded class D beta-lactamase OXA-23 in Proteus mirabilis
    R Bonnet
    Laboratoire de Bacteriologie, Faculte de Medecine, 63001 Clermont Ferrand cedex, France
    Antimicrob Agents Chemother 46:2004-6. 2002
  6. pmc A novel class A extended-spectrum beta-lactamase (BES-1) in Serratia marcescens isolated in Brazil
    R Bonnet
    Laboratoire de Bacteriologie, Faculte de Medecine, 63001 Clermont Ferrand cedex, France
    Antimicrob Agents Chemother 44:3061-8. 2000
  7. pmc A novel CTX-M beta-lactamase (CTX-M-8) in cefotaxime-resistant Enterobacteriaceae isolated in Brazil
    R Bonnet
    Laboratoire de Bacteriologie, Faculte de Medecine, 63001 Clermont Ferrand cedex, France
    Antimicrob Agents Chemother 44:1936-42. 2000
  8. pmc Novel cefotaximase (CTX-M-16) with increased catalytic efficiency due to substitution Asp-240-->Gly
    R Bonnet
    Laboratoire de Bacteriologie, Faculte de Medecine, 63001 Clermont Ferrand cedex, France
    Antimicrob Agents Chemother 45:2269-75. 2001
  9. pmc Unexpected enzyme TEM-126: role of mutation Asp179Glu
    J Delmas
    Faculte de Medecine, Centre Hospitalo Universitaire, Clermont Ferrand, France
    Antimicrob Agents Chemother 49:4280-7. 2005
  10. pmc Prevalence of beta-lactamases among 1,072 clinical strains of Proteus mirabilis: a 2-year survey in a French hospital
    C Chanal
    Laboratoire de Bacteriologie, Faculte de Medecine, 63001 Clermont Ferrand cedex, France
    Antimicrob Agents Chemother 44:1930-5. 2000

Collaborators

Detail Information

Publications43

  1. pmc Diversity of TEM mutants in Proteus mirabilis
    R Bonnet
    Laboratoire de Bacteriologie, Faculte de Medecine, 63001 Clermont Ferrand cedex, France
    Antimicrob Agents Chemother 43:2671-7. 1999
    ..mirabilis are evidence of the wide diversity of beta-lactamases produced in this species and of its possible role as a beta-lactamase-encoding plasmid reservoir...
  2. pmc Growing group of extended-spectrum beta-lactamases: the CTX-M enzymes
    R Bonnet
    Laboratoire de Bacteriologie, Faculte de Medecine, 63001 Clermont Ferrand cedex, France
    Antimicrob Agents Chemother 48:1-14. 2004
  3. ncbi request reprint Effect of D240G substitution in a novel ESBL CTX-M-27
    R Bonnet
    Laboratoire de Bacteriologie, Faculte de Medecine, Service de Bacteriologie Virologie, 28 Place Henri Dunant, 63001 Clermont Ferrand cedex, France
    J Antimicrob Chemother 52:29-35. 2003
    ....
  4. pmc Inducible AmpC beta-lactamase of a new member Enterobacteriaceae
    Richard Bonnet
    Laboratoire de Bacteriologie, Faculte de Medecine, 63001 Clermont Ferrand cedex, France
    Antimicrob Agents Chemother 46:3316-9. 2002
    ....
  5. pmc Chromosome-encoded class D beta-lactamase OXA-23 in Proteus mirabilis
    R Bonnet
    Laboratoire de Bacteriologie, Faculte de Medecine, 63001 Clermont Ferrand cedex, France
    Antimicrob Agents Chemother 46:2004-6. 2002
    ..mirabilis isolates originated from the same clonal strain. Hybridization of I-CeuI-generated chromosome fragments with a bla(OXA-23) probe showed that the gene was chromosome encoded in the P. mirabilis strain...
  6. pmc A novel class A extended-spectrum beta-lactamase (BES-1) in Serratia marcescens isolated in Brazil
    R Bonnet
    Laboratoire de Bacteriologie, Faculte de Medecine, 63001 Clermont Ferrand cedex, France
    Antimicrob Agents Chemother 44:3061-8. 2000
    ..BES-1, therefore, may be an interesting model for further investigations of the structure-function relationships of class A ESBLs...
  7. pmc A novel CTX-M beta-lactamase (CTX-M-8) in cefotaxime-resistant Enterobacteriaceae isolated in Brazil
    R Bonnet
    Laboratoire de Bacteriologie, Faculte de Medecine, 63001 Clermont Ferrand cedex, France
    Antimicrob Agents Chemother 44:1936-42. 2000
    ..The evolutionary distances between the four types of CTX-M were large, suggesting that the four clusters branched off early from a distant unknown enzyme and that intermediate enzymes probably existed...
  8. pmc Novel cefotaximase (CTX-M-16) with increased catalytic efficiency due to substitution Asp-240-->Gly
    R Bonnet
    Laboratoire de Bacteriologie, Faculte de Medecine, 63001 Clermont Ferrand cedex, France
    Antimicrob Agents Chemother 45:2269-75. 2001
    ..These reports are evidence of the diversity of CTX-M-type extended-spectrum beta-lactamases in Brazil...
  9. pmc Unexpected enzyme TEM-126: role of mutation Asp179Glu
    J Delmas
    Faculte de Medecine, Centre Hospitalo Universitaire, Clermont Ferrand, France
    Antimicrob Agents Chemother 49:4280-7. 2005
    ..Overall, these results highlight the remarkable plasticity of TEM enzymes, which can expand their activity against ceftazidime by the addition of one carbon atom in the side chain of residue 179...
  10. pmc Prevalence of beta-lactamases among 1,072 clinical strains of Proteus mirabilis: a 2-year survey in a French hospital
    C Chanal
    Laboratoire de Bacteriologie, Faculte de Medecine, 63001 Clermont Ferrand cedex, France
    Antimicrob Agents Chemother 44:1930-5. 2000
    ..The characterization of the different beta-lactamases showed that amoxicillin resistance in P. mirabilis was almost always (97%) associated with TEM or TEM-derived beta-lactamases, most of which evolved via TEM-2...
  11. pmc Effects of Ser130Gly and Asp240Lys substitutions in extended-spectrum beta-lactamase CTX-M-9
    C Aumeran
    Laboratoire de Bacteriologie, Faculte de Medecine, 63001 Clermont Ferrand, Cedex, France
    Antimicrob Agents Chemother 47:2958-61. 2003
    ..A D240K mutation did not modify enzymatic efficiency against ceftazidime. Residue K240 could interact with Q270 and therefore not with ceftazidime, in contrast with what was observed with certain TEM/SHV-type ESBLs...
  12. pmc TEM-109 (CMT-5), a natural complex mutant of TEM-1 beta-lactamase combining the amino acid substitutions of TEM-6 and TEM-33 (IRT-5)
    F Robin
    Faculte de Medecine, Centre Hospitalo Universitaire, Clermont Ferrand, France
    Antimicrob Agents Chemother 49:4443-7. 2005
    ..01 and 0.06 microM, respectively) but were almost 10-fold lower than those for TEM-33. The characterization of this novel CMT, which exhibits a low level of resistance to inhibitors, highlights the emergence of this new ESBL type...
  13. pmc Prediction of the evolution of ceftazidime resistance in extended-spectrum beta-lactamase CTX-M-9
    J Delmas
    Laboratoire de Bacteriologie, Faculte de Medecine, Centre Hospitalo Universitaire, Clermont Ferrand, France
    Antimicrob Agents Chemother 50:731-8. 2006
    ..The current emergence of CTX-M beta-lactamases with improved activity against ceftazidime may therefore be the beginning of an evolutionary process which might subsequently generate a great diversity of CTX-M-type ceftazidimases...
  14. pmc New TEM variant (TEM-92) produced by Proteus mirabilis and Providencia stuartii isolates
    C De Champs
    Laboratoire de Bacteriologie, Faculte de Medecine, 63001 Clermont Ferrand cedex, France
    Antimicrob Agents Chemother 45:1278-80. 2001
    ..The deduced amino acid sequence of TEM-92 differed from that of TEM-52 by the presence of a substitution (Gln-6-->Lys) in the peptide signal...
  15. pmc TEM derivative-producing Enterobacter aerogenes strains: dissemination of a prevalent clone
    P Dumarche
    Faculte de Medecine, Laboratoire de Bacteriologie, 63001 Clermont Ferrand cedex, France
    Antimicrob Agents Chemother 46:1128-31. 2002
    ..A clonal strain was found for TEM-24- but also for TEM-3- and TEM-1- or 2-producing isolates. This study shows that there is a clonal strain dependent on acquisition of the TEM-type enzyme (TEM-24 and other TEM types)...
  16. ncbi request reprint Clinical relevance of Proteus mirabilis in hospital patients: a two year survey
    C De Champs
    Laboratoire de Bacteriologie, Faculte de Medecine, 28, Place Henri Dunant, 63001 Clermont Ferrand cedex, France
    J Antimicrob Chemother 45:537-9. 2000
    ..ESBL-producing isolates were observed in long-stay and intensive care and IRB-producing isolates in paediatric units. Of the 95 patients whose charts were examined, 69 had a confirmed infection, which in 42 cases was nosocomial...
  17. pmc Sec- and Tat-dependent translocation of beta-lactamases across the Escherichia coli inner membrane
    N Pradel
    Laboratoire de Bacteriologie, Faculte de Medecine, Universite d Auvergne, Clermont Ferrand, France
    Antimicrob Agents Chemother 53:242-8. 2009
    ..coli. These findings provide new knowledge about beta-lactamase translocation, a putative new target for addressing beta-lactamase-mediated resistance...
  18. ncbi request reprint Four-year epidemiological study of extended-spectrum β-lactamase-producing Enterobacteriaceae in a French teaching hospital
    L Gibold
    Laboratoire de Bacteriologie, CHU Clermont Ferrand, Centre de Biologie, Clermont Ferrand, France Microbes, Intestins, Inflammation et Susceptibilité de l Hôte, Inserm U1071, INRA, USC2018, Clermont Universite, Universite d Auvergne, Clermont Ferrand, France
    Clin Microbiol Infect 20:O20-6. 2014
    ..In conclusion, ESBL-producing bacteria constantly increased during the study period. Unlike many studies, this increase was associated with the wide dissemination of three different CTX-M enzymes: CTX-M-14, CTX-M-15 and CTX-M-1...
  19. ncbi request reprint Evaluation of the Vitek-2 extended-spectrum beta-lactamase test against non-duplicate strains of Enterobacteriaceae producing a broad diversity of well-characterised beta-lactamases
    F Robin
    CHU Clermont Ferrand, Centre de Biologie, Laboratoire de Bactériologie Clinique, and Université Clermont 1, UFR Medecine, Laboratoire de Bacteriologie, EA3844, Clermont Ferrand, France
    Clin Microbiol Infect 14:148-54. 2008
    ..5%/100% for the Vitek-2 ESBL test. The Vitek-2 ESBL test seemed to be an efficient method for routine detection of ESBL-producing isolates of Enterobacteriaceae, including isolates producing AmpC-type enzymes...
  20. pmc A 1998 survey of extended-spectrum beta-lactamases in Enterobacteriaceae in France. The French Study Group
    C De Champs
    Laboratoire de Bacteriologie, Faculte de Medecine, Universite d Auvergne, 63001 Clermont Ferrand cedex, France
    Antimicrob Agents Chemother 44:3177-9. 2000
    ..The high proportion of TEM-24-like-producing Enterobacter aerogenes isolates (36 of 79) suggests the occurrence of an epidemic strain in France...
  21. pmc CTX-M-1, CTX-M-3, and CTX-M-14 beta-lactamases from Enterobacteriaceae isolated in France
    C Dutour
    Laboratoire de Bacteriologie, Faculte de Medecine, 63001 Clermont Ferrand cedex, France
    Antimicrob Agents Chemother 46:534-7. 2002
    ..The CTX-M-1- and CTX-M-3-encoding plasmids were related to the CTX-M-1- and CTX-M-3-encoding plasmids previously reported in 1990 in France and in 1998 in Poland, respectively...
  22. ncbi request reprint Decreased susceptibility to extended-spectrum cephalosporins of a penicillin-susceptible Streptococcus pneumoniae in meningitis
    C De Champs
    Service de Bacteriologie, Faculte de Medecine, Clermont Ferrand, France
    Infection 28:58-9. 2000
    ..Despite the possible detection of the resistance by oxacillin disk, it underlines the need to determine the MICs of different beta-lactams without delay and to choose the most efficient treatment...
  23. ncbi request reprint [VCA agar (bioMérieux) for selective isolation of vancomycin-resistant Enterococci (VRE) from fecal specimens]
    J Delmas
    Service de Bacteriologie, Faculte de Medecine, CHU Clermont Ferrand, 28 place H Dunant, 63001 Clermont Ferrand, France
    Pathol Biol (Paris) 53:485-9. 2005
    ..VCA3 agar avoided therefore additional subcultures, useless identification and susceptibility tests. In conclusion, VCA3 medium could be useful for the direct, rapid and selective isolation of VRE from fecal specimens...
  24. pmc Biochemical characterization of SHV-55, an extended-spectrum class A beta-lactamase from Klebsiella pneumoniae
    Nuno Mendonça
    Antimicrob Agents Chemother 52:1897-8. 2008
  25. pmc TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases
    Frederic Robin
    CHU Clermont Ferrand, Centre de Biologie, Laboratoire de bactériologiecinique, Faculte de Medecine, 28 place H Dunant, 63001 Clermont Ferrand, France
    Antimicrob Agents Chemother 51:4181-3. 2007
    ..This enzyme presented hydrolytic activity against ceftazidime and a high level of resistance against clavulanate, which can alter its detection. Its discovery highlights the need for accurate detection methods...
  26. pmc First occurrence of an IMP metallo-beta-lactamase in Aeromonas caviae: IMP-19 in an isolate from France
    Catherine Neuwirth
    Laboratoire de Bacteriologie, Hopital Universitaire du Bocage, BP 77908, 21079 Dijon Cedex, France
    Antimicrob Agents Chemother 51:4486-8. 2007
    ..bla(IMP-19) was found within a class 1 integron located on a 35-kb plasmid. This is also the first description of an IMP producer in France...
  27. ncbi request reprint Structure and dynamics of CTX-M enzymes reveal insights into substrate accommodation by extended-spectrum beta-lactamases
    Julien Delmas
    Laboratoire de Bacteriologie, CHU Clermont Ferrand, Clermont Ferrand F 63003, France
    J Mol Biol 375:192-201. 2008
    ....
  28. pmc Methicillin-susceptible, doxycycline-resistant Staphylococcus aureus, Côte d'Ivoire
    Olivier Lesens
    Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire, Clermont Ferrand, France
    Emerg Infect Dis 13:488-90. 2007
    ..In a transssectional survey, nasal carriage of this strain was found in 2.9% of 273 soldiers about to be sent to Côte d'Ivoire and was associated with prior malaria prophylaxis with doxycycline...
  29. doi request reprint Structure-function studies of arginine at position 276 in CTX-M beta-lactamases
    Francisco José Pérez-Llarena
    Servicio de Microbiologia, Unidad de Investigacion, Complejo Hospitalario Universitario Juan Canalejo, La Coruna, Spain
    J Antimicrob Chemother 61:792-7. 2008
    ..We also investigated the role of Arg276 in cefotaxime hydrolysis...
  30. pmc The Lys234Arg substitution in the enzyme SHV-72 is a determinant for resistance to clavulanic acid inhibition
    Nuno Mendonça
    Antibiotic Resistance Unit, Department of Infectious Diseases, National Institute of Health Dr Ricardo Jorge Av Padre Cruz, 1649 016 Lisbon, Portugal
    Antimicrob Agents Chemother 52:1806-11. 2008
    ..5 A away from the key O gamma atom of the reactive serine (Ser70). This movement may therefore decrease the susceptibility to clavulanic acid by preventing cross-linking between Ser130 and Ser70...
  31. pmc Streptobacillus moniliformis as the causative agent in spondylodiscitis and psoas abscess after rooster scratches
    Damien Dubois
    CHU Clermont Ferrand, Centre de Biologie, Laboratoire de Bactériologie Clinique, Clermont Ferrand F 63003, France
    J Clin Microbiol 46:2820-1. 2008
    ..S. moniliformis was identified from abscess fluid by use of 16S rRNA gene sequencing. After 18 weeks of antimicrobial therapy, the clinical condition of the patient improved...
  32. pmc Prospective survey of beta-lactamases produced by ceftazidime- resistant Pseudomonas aeruginosa isolated in a French hospital in 2000
    Christophe De Champs
    Service de Bacteriologie, Faculte de Medecine, Universite d Auvergne, 63001 Clermont Ferrand, France
    Antimicrob Agents Chemother 46:3031-4. 2002
    ..Sequencing of five bla(AmpC) genes encoding cephalosporinases with different pIs showed 99% identity with the ampC gene of P. aeruginosa PAO1...
  33. pmc Infection with an extended-spectrum beta-lactamase-producing strain of Serratia marcescens following tongue reconstruction
    Benu Dhawan
    Department of Microbiology, All India Institute of Medical Sciences, New Delhi 29, India
    J Clin Microbiol 41:2233-4. 2003
    ..marcescens and P. aeruginosa were resistant to the empirical perioperative antibiotics administered. Delay in the recognition of the type of infection and in the institution of appropriate therapy resulted in total loss of the free flap...
  34. ncbi request reprint Post-antibiotic and post-beta-lactamase inhibitor effects of ceftazidime plus sulbactam on extended-spectrum beta-lactamase-producing Gram-negative bacteria
    Jean Philippe Lavigne
    Laboratoire de Bacteriologie virologie, Centre Hospitalo Universitaire de Nîmes, Groupe Hospitalo Universitaire de Carémeau, place du Professeur Robert Debré, 30029 Nimes cedex 09, France
    J Antimicrob Chemother 53:616-9. 2004
    ..To measure the in vitro post-antibiotic effect (PAE) and post-beta-lactamase inhibitor effect (PLIE) of a ceftazidime-sulbactam combination on bacteria producing extended-spectrum beta-lactamases (ESBLs)...
  35. pmc Structure-based optimization of a non-beta-lactam lead results in inhibitors that do not up-regulate beta-lactamase expression in cell culture
    Donatella Tondi
    Department of Pharmaceutical Chemistry, University of California San Francisco, 600 16th Street, San Francisco, CA 94143 2240, USA
    J Am Chem Soc 127:4632-9. 2005
    ..Its escape from this resistance mechanism derives from its dissimilarity to beta-lactam antibiotics...
  36. ncbi request reprint Atomic resolution structures of CTX-M beta-lactamases: extended spectrum activities from increased mobility and decreased stability
    Yu Chen
    Department of Pharmaceutical Chemistry, University of California, San Francisco, Genentech Hall, 600 16th Street, San Francisco, CA 94143 2240, USA
    J Mol Biol 348:349-62. 2005
    ..The unusually high resolution of these structures that makes such analyses possible also makes them good templates for inhibitor discovery...
  37. pmc Structure, function, and inhibition along the reaction coordinate of CTX-M beta-lactamases
    Yu Chen
    Department of Pharmaceutical Chemistry, University of California, San Francisco, Genentech Hall, 600 16th Street, San Francisco, California 94143 2240, USA
    J Am Chem Soc 127:5423-34. 2005
    ..The structure of its complex with CTX-M enzyme and the structural view of the reaction coordinate described here provide templates for inhibitor design and intervention to combat this family of antibiotic resistance enzymes...
  38. pmc CMT-type beta-lactamase TEM-125, an emerging problem for extended-spectrum beta-lactamase detection
    Frederic Robin
    CHU Clermont Ferrand, Laboratoire de Bacteriologie, Faculte de Medecine, 63 001 Clermont Ferrand, France
    Antimicrob Agents Chemother 50:2403-8. 2006
    ....
  39. pmc qnrA in CTX-M-producing Escherichia coli isolates from France
    Jean Philippe Lavigne
    Laboratoire Universitaire d Antibiologie, UFR de Medecine, Avenue Kennedy, 30908 NIMES Cedex 02, France
    Antimicrob Agents Chemother 50:4224-8. 2006
    ..For the first time, 7.7% of CTX-M-producing E. coli isolates presented a plasmid-mediated resistance to quinolones. All strains harbored a qnrA gene located on a sul1-type class 1 integron with similar structure to the In36 integron...
  40. pmc CTX-M beta-lactamase-producing Escherichia coli in French hospitals: prevalence, molecular epidemiology, and risk factors
    Jean Philippe Lavigne
    Laboratoire Universitaire d Antibiologie, Faculte de Medecine, CS83021, Avenue Kennedy, 30908 NIMES Cedex 02, France
    J Clin Microbiol 45:620-6. 2007
    ..The main risk factors for acquiring these isolates were urinary tract infections or the presence of a urinary catheter in diabetic or renal failure patients...
  41. pmc Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient
    Frederic Robin
    CHU Clermont Ferrand, Centre de Biologie, Laboratoire de Bactériologie Clinique, Clermont Ferrand F 63003, France
    Antimicrob Agents Chemother 51:1304-9. 2007
    ..17 microM). These results confirm the evolution of TEM-type enzymes toward complex enzymes harboring the two kinds of substitutions which confer an extended spectrum of action against beta-lactam antibiotics and resistance to inhibitors...
  42. ncbi request reprint Type II topoisomerase mutations in clinical isolates of Enterobacter cloacae and other enterobacterial species harbouring the qnrA gene
    Christine Lascols
    Universite Paris 12, CHU Henri Mondor, AP HP, Bactériologie Virologie Hygiène, Creteil, France
    Int J Antimicrob Agents 29:402-9. 2007
    ....
  43. pmc The acylation mechanism of CTX-M beta-lactamase at 0.88 a resolution
    Yu Chen
    Department of Pharmaceutical Chemistry, University of California San Francisco, 1700 4th Street, MC 2550, San Francisco, California 94158 2330, USA
    J Am Chem Soc 129:5378-80. 2007