Research Topics
Species | Laurent BonelloSummaryCountry: France Publications
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Publications
Adjusted clopidogrel loading doses according to vasodilator-stimulated phosphoprotein phosphorylation index decrease rate of major adverse cardiovascular events in patients with clopidogrel resistance: a multicenter randomized prospective studyLaurent Bonello
Service de cardiologie, Hopital Universitaire Nord, Marseille, France
J Am Coll Cardiol 51:1404-11. 2008....- Unveiling the mysteries of clopidogrel metabolism and efficacyL Bonello
Department of Cardiology, Hopital Universitaire Nord, Faculte de Medecine de Marseille, Marseille, France
Clin Pharmacol Ther 90:774-6. 2011..Paraoxonase 1 has been identified as the main determinant of the biological and clinical efficacy of clopidogrel. This finding could enable the use of pharmacogenomics to tailor antiplatelet agents... - Relationship between post-treatment platelet reactivity and ischemic and bleeding events at 1-year follow-up in patients receiving prasugrelL Bonello
Departement de Cardiologie, Hopital Universitaire Nord, Aix Marseille Univ, France
J Thromb Haemost 10:1999-2005. 2012..Post-treatment platelet reactivity (PR) is associated with ischemic and bleeding events in patients receiving P2Y12 receptor antagonists... - Mobilization of CD34+ KDR+ endothelial progenitor cells predicts target lesion revascularizationL Bonello
Departement de Cardiologie, Hopital Universitaire Nord, Faculte de Medecine, Aix Marseille Universite, Marseille, France
J Thromb Haemost 10:1906-13. 2012..Endothelial lesion and regeneration are critical events in the process leading to in-stent restenosis (ISR) after bare metal stent (BMS) percutaneous coronary intervention (PCI)... - Factors associated with the failure of clopidogrel dose-adjustment according to platelet reactivity monitoring to optimize P2Y12-ADP receptor blockadeLaurent Bonello
Departement de Cardiologie, Hopital Universitaire Nord, Faculte de Medecine, Aix Marseille Universite, Marseille, France
Thromb Res 130:70-4. 2012..Dose-adjustment was performed using up-to 3 additional loading doses (LD) of 600mg clopidogrel in order to obtain a VASP <50% in patients with HTPR following the first LD... - Biological efficacy of a 600 mg loading dose of clopidogrel in ST-elevation myocardial infarctionLaurent Bonello
Departement de Cardiologie, Hopital Universitaire Nord, Aix Marseille University, Marseille, France
Thromb Haemost 108:101-6. 2012..The present results suggest that 600 mg of clopidogrel may not be able to achieve an optimal PR inhibition in STEMI patients undergoing PCI and more potent drugs may be preferred... - High on-treatment platelet reactivity after prasugrel loading dose and cardiovascular events after percutaneous coronary intervention in acute coronary syndromesLaurent Bonello
Departement de Cardiologie, Hopital Universitaire Nord, Faculte de Medecine, Chemin des Bourrely, Marseille, France
J Am Coll Cardiol 58:467-73. 2011..The aim of this study was to investigate the relationship between platelet reactivity (PR) after a loading dose (LD) of prasugrel and thrombotic events... - Clopidogrel loading dose adjustment according to platelet reactivity monitoring in patients carrying the 2C19*2 loss of function polymorphismLaurent Bonello
Departement de Cardiologie, Hopital Universitaire Nord, Faculte de Medecine, Universite de la Mediterranee, Marseille, France
J Am Coll Cardiol 56:1630-6. 2010.... - Tailored clopidogrel loading dose according to platelet reactivity monitoring to prevent acute and subacute stent thrombosisLaurent Bonello
Departement de Cardiologie, Hopital Universitaire Nord, Faculte de Medecine, France
Am J Cardiol 103:5-10. 2009..8% vs 3.7%, p = 0.8). In conclusion, a tailored clopidogrel LD according to platelet reactivity monitoring decreases the rate of early stent thrombosis after PCI without increasing bleeding... - Personalized antiplatelet therapy for coronary artery disease patients: is this the future?Laurent Bonello
Pôle de cardiologie, Hopital Universitaire Nord, Chemin des Bourrely, 13015 Marseille, France
Expert Rev Cardiovasc Ther 7:1525-32. 2009..The development of new antiplatelet agents and the increasing availability of platelet assays are likely to profoundly modify current practice and favor personalized antiplatelet therapy... - Impact of P2Y12-ADP receptor polymorphism on the efficacy of clopidogrel dose-adjustment according to platelet reactivity monitoring in coronary artery disease patientsLaurent Bonello
Departement de Cardiologie, Hopital Universitaire Nord, Faculte de Medecine, Marseille, France
Thromb Res 125:e167-70. 2010..However this strategy failed in nearly 10% of patients with HTPR. We aimed to determine if P2Y12-ADP receptor polymorphisms were associated with failed dose adjustment... 
Tailoring antiplatelet therapy: a step toward individualized therapy to improve clinical outcome?Marc Laine
Departement de Cardiologie, Hopital universtaire nord de Marseille, Assistance Publique Hopitaux de Marseille, Aix Marseille univ France, Marseille, France
Curr Pharm Des 18:5392-401. 2012....- Relation of body mass index to high on-treatment platelet reactivity and of failed clopidogrel dose adjustment according to platelet reactivity monitoring in patients undergoing percutaneous coronary interventionNathalie Bonello-Palot
Departement de Genetique Medicale, Hôpital de la Timone enfant, Marseille, France
Am J Cardiol 104:1511-5. 2009..Dose adjustment overcomes HTPR in carriers of the CYP2C19 2 allele. BMI is the only independent predictor of failed dose adjustment. Thus, drug underdosage seems to be the main determinant of HTPR... - Intra-individual variability in clopidogrel responsiveness in coronary artery disease patients under long term therapySebastien Armero
Pôle de cardiologie, Service de cardiologie interventionnelle, Hopital Universitaire Nord, AP HM, Faculte de Medecine, Université Aix Marseille II, France
Platelets 21:503-7. 2010..Decreased clopidogrel responsiveness despite long-term clopidogrel therapy could be a trigger for recurrent thrombotic events... - Early and late outcomes of clopidogrel and coumadin combination for patients on oral anticoagulants undergoing coronary stentingOmar Ait Mokhtar
Department of Cardiology, Centre Hospitalo Universitaire Nord, chemin des Bourrelys, 13015 Marseille, France
Cardiovasc Revasc Med 11:159-62. 2010..Triple therapy and dual therapy using aspirin and OAC have been evaluated and are associated with a high frequency of major bleedings. The combination of clopidogrel and OAC has never been evaluated... - Rate of nuisance bleedings and impact on compliance to prasugrel in acute coronary syndromesSebastien Armero
Departement de Cardiologie, Hopital Universitaire Nord, Faculte de Medecine, Universite de la Mediterranee, Marseille, France
Am J Cardiol 108:1710-3. 2011..In conclusion, in the present study, minor bleedings were common during the first month after percutaneous coronary intervention and were significantly associated with prasugrel withdrawal... - High on treatment platelet reactivityOmar Ait-Mokhtar
Department of Cardiology, Centre Hospitalier Universitaire Nord, Marseille 13015, France
Heart Lung Circ 21:12-21. 2012..Recent studies had demonstrated a relationship between HTPR and ischaemic events in the setting of PCI. Actually the assessment of platelet reactivity in routine practice and its interpretation to make a decision is a debatable issue... - Dosing strategies for antiplatelet therapy in percutaneous coronary interventionGilles Lemesle
Pôle de cardiologie, Hopital Cardiologique, Service de Cardiologie B et Centre Hémodynamique, Centre Hospitalier Regional et Universitaire de Lille, Lille, France
Hosp Pract (Minneap) 38:50-8. 2010..We review the recent data on efficacy and safety of dosing strategies for antiplatelet therapy in PCI... - Consensus and future directions on the definition of high on-treatment platelet reactivity to adenosine diphosphateLaurent Bonello
Department of Cardiology, Institut National de la Santè et de la Recherche Médicale Unité Mixte de Recherche 608, Hopital Universitaire Nord, Faculte de Medecine, Marseille, France
J Am Coll Cardiol 56:919-33. 2010..This review provides a consensus opinion on the definition of high on-treatment platelet reactivity to ADP based on various methods reported in the literature and proposes how this measurement may be used in the future care of patients... - Personalized antiplatelet therapy: review of the latest clinical evidenceElise Camilleri
Service de cardiologie, Hôpital de Martigues, Martigues, France
Curr Cardiol Rep 13:296-302. 2011..While the future of genetic testing remains undetermined, several trials are underway to demonstrate the potential utility of platelet reactivity testing with P2Y12-ADP receptor antagonists... - Level of adenosine diphosphate receptor P2Y12 blockade during percutaneous coronary intervention predicts the extent of endothelial injury, assessed by circulating endothelial cell measurementLaurent Bonello
Departement de Cardiologie, Hopital Universitaire Nord, Assistance Publique Hopitaux de Marseille, Université Aix Méditerranée, Faculte de Medecine, Marseille, France
J Am Coll Cardiol 56:1024-31. 2010..We aimed to investigate whether clopidogrel-induced inhibition of platelet reactivity could reduce the level of circulating endothelial cells (CEC), reflecting the endothelial injury induced by percutaneous coronary intervention (PCI)... - Genotypic and phenotypic assessment of platelet function and response to P2Y12 antagonistsAxel de Labriolle
Service de cardiologie, Clinique du Pont de Chaume, Montauban, France
Curr Cardiol Rep 13:439-50. 2011.... - Clinical impact of genetically determined platelet reactivityMarc Laine
Departement de Cardiologie, Centre Hospitalo Universitaire Nord, Chemin des Bourrely, Marseille, France
J Cardiovasc Transl Res 6:398-403. 2013..Large-scale randomized trials with clinical endpoints remain necessary to determine the optimal antiplatelet therapy in patients carrying genetic polymorphism associated with HTPR and thrombotic events... - Characteristics of isolated atrial flutter versus atrial flutter combined with atrial fibrillationMichael Peyrol
School of Medicine, Universite de la Mediterrane, Hopital Nord, Division of Cardiology, Marseille, France
Arch Cardiovasc Dis 104:530-5. 2011..Whether the characteristics of isolated AFL are different from those of patients with AFL combined with AF is still unclear... - Predictors of B-type natriuretic peptide and left atrial volume index in patients with preserved left ventricular systolic function: an echocardiographic-catheterization studyMarie Perrine Jaubert
Department of Cardiology, Centre Hospitalo Universitaire Nord, Marseille, France
Arch Cardiovasc Dis 103:3-9. 2010..Little is known, however, about predictors in patients with preserved systolic function... - Diagnostic performance of computed tomography coronary angiography (from the Prospective National Multicenter Multivendor EVASCAN Study)Pascal Gueret
Department of Cardiology, Henri Mondor Hospital and University of Paris Est Créteil, Creteil, France
Am J Cardiol 111:471-8. 2013.... - A pitfall of fractional flow reserve measurementOmar Ait Mokhtar
Hopital Universitaire Nord de Marseille, Departement de Cardiologie, Marseille, France
J Invasive Cardiol 22:E110-1. 2010..However there are some limitations to its use. We observed that in patients with an occluded artery, FFR measurements in the vessel supplying collaterals can be underestimated leading to inappropriate therapy... 
Protective effect of an acute oral loading dose of trimetazidine on myocardial injury following percutaneous coronary interventionLaurent Bonello
Division of Cardiology, Hospital Nord, University of Marseille, School of Medicine, Marseille, France
Heart 93:703-7. 2007..To evaluate the effect of pre-procedural acute oral administration of trimetazidine (TMZ) on percutaneous coronary intervention (PCI)-induced myocardial injury...- An atypical case of acute myocardial infarctionMarc Laine
Hopital Universitaire Nord de Marseille, Marseille, France
J Invasive Cardiol 23:305-6. 2011..Unfortunately, in this case, refractory cardiogenic shock postponed surgical repair and led to the patient's death... - Latest evidence in personalized antiplatelet therapy in patients with acute coronary syndromes undergoing percutaneous coronary interventionSabrina Uhry
Departement de Cardiologie, Hopital Universitaire Nord de Marseille, Assistance Publique Hopitaux de Marseille, Aix Marseille Universite, France
Hosp Pract (1995) 40:104-17. 2012..With the results of these trials, in addition to the evidence of a therapeutic window with P2Y12 ADP receptor antagonists, we summarize the potential of platelet reactivity monitoring and pharmacogenomics to tailor therapy... - Bivalirudin with provisional glycoprotein IIb/IIIa inhibitors in patients undergoing primary angioplasty in the setting of cardiogenic shockLaurent Bonello
Department of Internal Medicine, Division of Cardiology, Washington Hospital Center, Washington, DC, USA
Am J Cardiol 102:287-91. 2008..46). In conclusion, bivalirudin with provisional use of glycoprotein IIb/IIIa inhibitors appears to be a safe and effective anticoagualtion strategy in patients undergoing primary PCI for acute myocardial infarction complicated by CS...