Laurent Bonello

Summary

Country: France

Publications

  1. doi request reprint Adjusted clopidogrel loading doses according to vasodilator-stimulated phosphoprotein phosphorylation index decrease rate of major adverse cardiovascular events in patients with clopidogrel resistance: a multicenter randomized prospective study
    Laurent Bonello
    Service de cardiologie, Hopital Universitaire Nord, Marseille, France
    J Am Coll Cardiol 51:1404-11. 2008
  2. doi request reprint Ticagrelor increases adenosine plasma concentration in patients with an acute coronary syndrome
    Laurent Bonello
    Departement de Cardiologie, Hopital Universitaire Nord de Marseille, Assistance Publique Hopitaux de Marseille, Marseille, France INSERM UMRS 1076, Aix Marseille University, Marseille, France Electronic address
    J Am Coll Cardiol 63:872-7. 2014
  3. doi request reprint Ticagrelor versus prasugrel in diabetic patients with an acute coronary syndrome. A pharmacodynamic randomised study
    Marc Laine
    Laurent Bonello, MD, PhD, Department of Cardiology, Hopital Universitaire Nord, Chemin des Bourrely, 13015 Marseille, France, Tel 33 491 968 858, Fax 33 491 968 979, E mail
    Thromb Haemost 111:273-8. 2014
  4. ncbi request reprint A randomized trial of platelet reactivity monitoring-adjusted clopidogrel therapy versus prasugrel therapy to reduce high on-treatment platelet reactivity
    Laurent Bonello
    Departement de Cardiologie, Hopital Universitaire Nord, Aix Marseille Univ, Marseille, France INSERM UMRS 608, UFR de Pharmacie, Marseille, France Electronic address
    Int J Cardiol 168:4244-8. 2013
  5. doi request reprint Unveiling the mysteries of clopidogrel metabolism and efficacy
    L Bonello
    Department of Cardiology, Hopital Universitaire Nord, Faculte de Medecine de Marseille, Marseille, France
    Clin Pharmacol Ther 90:774-6. 2011
  6. doi request reprint Relationship between post-treatment platelet reactivity and ischemic and bleeding events at 1-year follow-up in patients receiving prasugrel
    L Bonello
    Departement de Cardiologie, Hopital Universitaire Nord, Aix Marseille Univ, France
    J Thromb Haemost 10:1999-2005. 2012
  7. ncbi request reprint Mobilization of CD34+ KDR+ endothelial progenitor cells predicts target lesion revascularization
    L Bonello
    Departement de Cardiologie, Hopital Universitaire Nord, Faculte de Medecine, Aix Marseille Universite, Marseille, France
    J Thromb Haemost 10:1906-13. 2012
  8. doi request reprint Factors associated with the failure of clopidogrel dose-adjustment according to platelet reactivity monitoring to optimize P2Y12-ADP receptor blockade
    Laurent Bonello
    Departement de Cardiologie, Hopital Universitaire Nord, Faculte de Medecine, Aix Marseille Universite, Marseille, France
    Thromb Res 130:70-4. 2012
  9. doi request reprint Biological efficacy of a 600 mg loading dose of clopidogrel in ST-elevation myocardial infarction
    Laurent Bonello
    Departement de Cardiologie, Hopital Universitaire Nord, Aix Marseille University, Marseille, France
    Thromb Haemost 108:101-6. 2012
  10. doi request reprint Personalized antiplatelet therapy for coronary artery disease patients: is this the future?
    Laurent Bonello
    Pôle de cardiologie, Hopital Universitaire Nord, Chemin des Bourrely, 13015 Marseille, France
    Expert Rev Cardiovasc Ther 7:1525-32. 2009

Detail Information

Publications37

  1. doi request reprint Adjusted clopidogrel loading doses according to vasodilator-stimulated phosphoprotein phosphorylation index decrease rate of major adverse cardiovascular events in patients with clopidogrel resistance: a multicenter randomized prospective study
    Laurent Bonello
    Service de cardiologie, Hopital Universitaire Nord, Marseille, France
    J Am Coll Cardiol 51:1404-11. 2008
    ....
  2. doi request reprint Ticagrelor increases adenosine plasma concentration in patients with an acute coronary syndrome
    Laurent Bonello
    Departement de Cardiologie, Hopital Universitaire Nord de Marseille, Assistance Publique Hopitaux de Marseille, Marseille, France INSERM UMRS 1076, Aix Marseille University, Marseille, France Electronic address
    J Am Coll Cardiol 63:872-7. 2014
    ..This study aimed to investigate the impact of ticagrelor on adenosine plasma concentration (APC) in acute coronary syndrome (ACS) patients...
  3. doi request reprint Ticagrelor versus prasugrel in diabetic patients with an acute coronary syndrome. A pharmacodynamic randomised study
    Marc Laine
    Laurent Bonello, MD, PhD, Department of Cardiology, Hopital Universitaire Nord, Chemin des Bourrely, 13015 Marseille, France, Tel 33 491 968 858, Fax 33 491 968 979, E mail
    Thromb Haemost 111:273-8. 2014
    ..The present study demonstrates that ticagrelor LD is superior to prasugrel LD to reduce PR in ACS patients with diabetes mellitus. Whether the higher potency of ticagrelor could translate into a clinical benefit should be investigated...
  4. ncbi request reprint A randomized trial of platelet reactivity monitoring-adjusted clopidogrel therapy versus prasugrel therapy to reduce high on-treatment platelet reactivity
    Laurent Bonello
    Departement de Cardiologie, Hopital Universitaire Nord, Aix Marseille Univ, Marseille, France INSERM UMRS 608, UFR de Pharmacie, Marseille, France Electronic address
    Int J Cardiol 168:4244-8. 2013
    ..We aimed to compare a strategy of clopidogrel loading dose-adjustment (CDA) according to PR monitoring with standard prasugrel therapy to reduce the rate of patients exhibiting HTPR...
  5. doi request reprint Unveiling the mysteries of clopidogrel metabolism and efficacy
    L Bonello
    Department of Cardiology, Hopital Universitaire Nord, Faculte de Medecine de Marseille, Marseille, France
    Clin Pharmacol Ther 90:774-6. 2011
    ..Paraoxonase 1 has been identified as the main determinant of the biological and clinical efficacy of clopidogrel. This finding could enable the use of pharmacogenomics to tailor antiplatelet agents...
  6. doi request reprint Relationship between post-treatment platelet reactivity and ischemic and bleeding events at 1-year follow-up in patients receiving prasugrel
    L Bonello
    Departement de Cardiologie, Hopital Universitaire Nord, Aix Marseille Univ, France
    J Thromb Haemost 10:1999-2005. 2012
    ..Post-treatment platelet reactivity (PR) is associated with ischemic and bleeding events in patients receiving P2Y12 receptor antagonists...
  7. ncbi request reprint Mobilization of CD34+ KDR+ endothelial progenitor cells predicts target lesion revascularization
    L Bonello
    Departement de Cardiologie, Hopital Universitaire Nord, Faculte de Medecine, Aix Marseille Universite, Marseille, France
    J Thromb Haemost 10:1906-13. 2012
    ..Endothelial lesion and regeneration are critical events in the process leading to in-stent restenosis (ISR) after bare metal stent (BMS) percutaneous coronary intervention (PCI)...
  8. doi request reprint Factors associated with the failure of clopidogrel dose-adjustment according to platelet reactivity monitoring to optimize P2Y12-ADP receptor blockade
    Laurent Bonello
    Departement de Cardiologie, Hopital Universitaire Nord, Faculte de Medecine, Aix Marseille Universite, Marseille, France
    Thromb Res 130:70-4. 2012
    ..We aimed to investigate the impact of 3 genetic polymorphisms involved in clopidogrel metabolism on a strategy of dose-adjustment according to platelet reactivity (PR) monitoring...
  9. doi request reprint Biological efficacy of a 600 mg loading dose of clopidogrel in ST-elevation myocardial infarction
    Laurent Bonello
    Departement de Cardiologie, Hopital Universitaire Nord, Aix Marseille University, Marseille, France
    Thromb Haemost 108:101-6. 2012
    ..The present results suggest that 600 mg of clopidogrel may not be able to achieve an optimal PR inhibition in STEMI patients undergoing PCI and more potent drugs may be preferred...
  10. doi request reprint Personalized antiplatelet therapy for coronary artery disease patients: is this the future?
    Laurent Bonello
    Pôle de cardiologie, Hopital Universitaire Nord, Chemin des Bourrely, 13015 Marseille, France
    Expert Rev Cardiovasc Ther 7:1525-32. 2009
    ..The development of new antiplatelet agents and the increasing availability of platelet assays are likely to profoundly modify current practice and favor personalized antiplatelet therapy...
  11. doi request reprint Tailored clopidogrel loading dose according to platelet reactivity monitoring to prevent acute and subacute stent thrombosis
    Laurent Bonello
    Departement de Cardiologie, Hopital Universitaire Nord, Faculte de Medecine, France
    Am J Cardiol 103:5-10. 2009
    ..8% vs 3.7%, p = 0.8). In conclusion, a tailored clopidogrel LD according to platelet reactivity monitoring decreases the rate of early stent thrombosis after PCI without increasing bleeding...
  12. doi request reprint High on-treatment platelet reactivity after prasugrel loading dose and cardiovascular events after percutaneous coronary intervention in acute coronary syndromes
    Laurent Bonello
    Departement de Cardiologie, Hopital Universitaire Nord, Faculte de Medecine, Chemin des Bourrely, Marseille, France
    J Am Coll Cardiol 58:467-73. 2011
    ..The aim of this study was to investigate the relationship between platelet reactivity (PR) after a loading dose (LD) of prasugrel and thrombotic events...
  13. doi request reprint Impact of P2Y12-ADP receptor polymorphism on the efficacy of clopidogrel dose-adjustment according to platelet reactivity monitoring in coronary artery disease patients
    Laurent Bonello
    Departement de Cardiologie, Hopital Universitaire Nord, Faculte de Medecine, Marseille, France
    Thromb Res 125:e167-70. 2010
    ..However this strategy failed in nearly 10% of patients with HTPR. We aimed to determine if P2Y12-ADP receptor polymorphisms were associated with failed dose adjustment...
  14. doi request reprint Clopidogrel loading dose adjustment according to platelet reactivity monitoring in patients carrying the 2C19*2 loss of function polymorphism
    Laurent Bonello
    Departement de Cardiologie, Hopital Universitaire Nord, Faculte de Medecine, Universite de la Mediterranee, Marseille, France
    J Am Coll Cardiol 56:1630-6. 2010
    ....
  15. ncbi request reprint Tailoring antiplatelet therapy: a step toward individualized therapy to improve clinical outcome?
    Marc Laine
    Departement de Cardiologie, Hopital universtaire nord de Marseille, Assistance Publique Hopitaux de Marseille, Aix Marseille univ France, Marseille, France
    Curr Pharm Des 18:5392-401. 2012
    ....
  16. doi request reprint Clinical impact of genetically determined platelet reactivity
    Marc Laine
    Departement de Cardiologie, Centre Hospitalo Universitaire Nord, Chemin des Bourrely, Marseille, France
    J Cardiovasc Transl Res 6:398-403. 2013
    ..Large-scale randomized trials with clinical endpoints remain necessary to determine the optimal antiplatelet therapy in patients carrying genetic polymorphism associated with HTPR and thrombotic events...
  17. doi request reprint Relation of body mass index to high on-treatment platelet reactivity and of failed clopidogrel dose adjustment according to platelet reactivity monitoring in patients undergoing percutaneous coronary intervention
    Nathalie Bonello-Palot
    Departement de Genetique Medicale, Hôpital de la Timone enfant, Marseille, France
    Am J Cardiol 104:1511-5. 2009
    ..Dose adjustment overcomes HTPR in carriers of the CYP2C19 2 allele. BMI is the only independent predictor of failed dose adjustment. Thus, drug underdosage seems to be the main determinant of HTPR...
  18. ncbi request reprint Assessing post-treatment platelet reactivity: a focus on patient selection and setting
    Marc Laine
    Departement de Cardiologie, Hopital Universitaire Nord, Marseille, France
    Expert Rev Cardiovasc Ther 11:1557-66. 2013
    ..However, such strategies remain to be evaluated in adequately designed large-scale randomized clinical trials...
  19. doi request reprint Intra-individual variability in clopidogrel responsiveness in coronary artery disease patients under long term therapy
    Sebastien Armero
    Pôle de cardiologie, Service de cardiologie interventionnelle, Hopital Universitaire Nord, AP HM, Faculte de Medecine, Université Aix Marseille II, France
    Platelets 21:503-7. 2010
    ..Decreased clopidogrel responsiveness despite long-term clopidogrel therapy could be a trigger for recurrent thrombotic events...
  20. doi request reprint Early and late outcomes of clopidogrel and coumadin combination for patients on oral anticoagulants undergoing coronary stenting
    Omar Ait Mokhtar
    Department of Cardiology, Centre Hospitalo Universitaire Nord, chemin des Bourrelys, 13015 Marseille, France
    Cardiovasc Revasc Med 11:159-62. 2010
    ..Triple therapy and dual therapy using aspirin and OAC have been evaluated and are associated with a high frequency of major bleedings. The combination of clopidogrel and OAC has never been evaluated...
  21. doi request reprint Platelet reactivity evaluated with the VASP assay following ticagrelor loading dose in acute coronary syndrome patients undergoing percutaneous coronary intervention
    Marc Laine
    Departement de Cardiologie, Hopital Universitaire Nord, Aix Marseille Univ, Marseille, France
    Thromb Res 132:e15-8. 2013
    ....
  22. doi request reprint Rate of nuisance bleedings and impact on compliance to prasugrel in acute coronary syndromes
    Sebastien Armero
    Departement de Cardiologie, Hopital Universitaire Nord, Faculte de Medecine, Universite de la Mediterranee, Marseille, France
    Am J Cardiol 108:1710-3. 2011
    ..In conclusion, in the present study, minor bleedings were common during the first month after percutaneous coronary intervention and were significantly associated with prasugrel withdrawal...
  23. doi request reprint High on treatment platelet reactivity
    Omar Ait-Mokhtar
    Department of Cardiology, Centre Hospitalier Universitaire Nord, Marseille 13015, France
    Heart Lung Circ 21:12-21. 2012
    ..Recent studies had demonstrated a relationship between HTPR and ischaemic events in the setting of PCI. Actually the assessment of platelet reactivity in routine practice and its interpretation to make a decision is a debatable issue...
  24. doi request reprint Intracoronary administration of darbepoetin-alpha at onset of reperfusion in acute myocardial infarction: results of the randomized Intra-Co-EpoMI trial
    Francois Roubille
    Departement de Cardiologie, pôle cœur poumon, Hopital Arnaud de Villeneuve, CHU de Montpellier, UFR de Medecine, Universite Montpellier 1, CNRS, UMR 5203, France
    Arch Cardiovasc Dis 106:135-45. 2013
    ..These trials could have missed crucial events occurring in the first few minutes of reperfusion. Our study differs by earlier intracoronary administration of a longer-acting erythropoietin analogue at the onset of reperfusion...
  25. ncbi request reprint Dosing strategies for antiplatelet therapy in percutaneous coronary intervention
    Gilles Lemesle
    Pôle de cardiologie, Hopital Cardiologique, Service de Cardiologie B et Centre Hémodynamique, Centre Hospitalier Regional et Universitaire de Lille, Lille, France
    Hosp Pract (1995) 38:50-8. 2010
    ..We review the recent data on efficacy and safety of dosing strategies for antiplatelet therapy in PCI...
  26. doi request reprint Level of adenosine diphosphate receptor P2Y12 blockade during percutaneous coronary intervention predicts the extent of endothelial injury, assessed by circulating endothelial cell measurement
    Laurent Bonello
    Departement de Cardiologie, Hopital Universitaire Nord, Assistance Publique Hopitaux de Marseille, Université Aix Méditerranée, Faculte de Medecine, Marseille, France
    J Am Coll Cardiol 56:1024-31. 2010
    ..We aimed to investigate whether clopidogrel-induced inhibition of platelet reactivity could reduce the level of circulating endothelial cells (CEC), reflecting the endothelial injury induced by percutaneous coronary intervention (PCI)...
  27. doi request reprint Personalized antiplatelet therapy: review of the latest clinical evidence
    Elise Camilleri
    Service de cardiologie, Hôpital de Martigues, Martigues, France
    Curr Cardiol Rep 13:296-302. 2011
    ..While the future of genetic testing remains undetermined, several trials are underway to demonstrate the potential utility of platelet reactivity testing with P2Y12-ADP receptor antagonists...
  28. doi request reprint Consensus and future directions on the definition of high on-treatment platelet reactivity to adenosine diphosphate
    Laurent Bonello
    Department of Cardiology, Institut National de la Santè et de la Recherche Médicale Unité Mixte de Recherche 608, Hopital Universitaire Nord, Faculte de Medecine, Marseille, France
    J Am Coll Cardiol 56:919-33. 2010
    ..This review provides a consensus opinion on the definition of high on-treatment platelet reactivity to ADP based on various methods reported in the literature and proposes how this measurement may be used in the future care of patients...
  29. doi request reprint Genotypic and phenotypic assessment of platelet function and response to P2Y12 antagonists
    Axel de Labriolle
    Service de cardiologie, Clinique du Pont de Chaume, Montauban, France
    Curr Cardiol Rep 13:439-50. 2011
    ....
  30. doi request reprint Characteristics of isolated atrial flutter versus atrial flutter combined with atrial fibrillation
    Michael Peyrol
    School of Medicine, Universite de la Mediterrane, Hopital Nord, Division of Cardiology, Marseille, France
    Arch Cardiovasc Dis 104:530-5. 2011
    ..AF may be a stable, "isolated" rhythm, a bridge between sinus rhythm and AF, or both arrhythmias can coexist. Whether the characteristics of isolated AFL are different from those of patients with AFL combined with AF is still unclear...
  31. doi request reprint Predictors of B-type natriuretic peptide and left atrial volume index in patients with preserved left ventricular systolic function: an echocardiographic-catheterization study
    Marie Perrine Jaubert
    Department of Cardiology, Centre Hospitalo Universitaire Nord, Marseille, France
    Arch Cardiovasc Dis 103:3-9. 2010
    ..Little is known, however, about predictors in patients with preserved systolic function...
  32. doi request reprint Diagnostic performance of computed tomography coronary angiography (from the Prospective National Multicenter Multivendor EVASCAN Study)
    Pascal Gueret
    Department of Cardiology, Henri Mondor Hospital and University of Paris Est Créteil, Creteil, France
    Am J Cardiol 111:471-8. 2013
    ....
  33. ncbi request reprint A pitfall of fractional flow reserve measurement
    Omar Ait Mokhtar
    Hopital Universitaire Nord de Marseille, Departement de Cardiologie, Marseille, France
    J Invasive Cardiol 22:E110-1. 2010
    ..However there are some limitations to its use. We observed that in patients with an occluded artery, FFR measurements in the vessel supplying collaterals can be underestimated leading to inappropriate therapy...
  34. pmc Protective effect of an acute oral loading dose of trimetazidine on myocardial injury following percutaneous coronary intervention
    Laurent Bonello
    Division of Cardiology, Hospital Nord, University of Marseille, School of Medicine, Marseille, France
    Heart 93:703-7. 2007
    ..To evaluate the effect of pre-procedural acute oral administration of trimetazidine (TMZ) on percutaneous coronary intervention (PCI)-induced myocardial injury...
  35. ncbi request reprint An atypical case of acute myocardial infarction
    Marc Laine
    Hopital Universitaire Nord de Marseille, Marseille, France
    J Invasive Cardiol 23:305-6. 2011
    ..Unfortunately, in this case, refractory cardiogenic shock postponed surgical repair and led to the patient's death...
  36. doi request reprint Latest evidence in personalized antiplatelet therapy in patients with acute coronary syndromes undergoing percutaneous coronary intervention
    Sabrina Uhry
    Departement de Cardiologie, Hopital Universitaire Nord de Marseille, Assistance Publique Hopitaux de Marseille, Aix Marseille Universite, France
    Hosp Pract (1995) 40:104-17. 2012
    ..With the results of these trials, in addition to the evidence of a therapeutic window with P2Y12 ADP receptor antagonists, we summarize the potential of platelet reactivity monitoring and pharmacogenomics to tailor therapy...
  37. doi request reprint Bivalirudin with provisional glycoprotein IIb/IIIa inhibitors in patients undergoing primary angioplasty in the setting of cardiogenic shock
    Laurent Bonello
    Department of Internal Medicine, Division of Cardiology, Washington Hospital Center, Washington, DC, USA
    Am J Cardiol 102:287-91. 2008
    ..46). In conclusion, bivalirudin with provisional use of glycoprotein IIb/IIIa inhibitors appears to be a safe and effective anticoagualtion strategy in patients undergoing primary PCI for acute myocardial infarction complicated by CS...