M Bomsel

Summary

Country: France

Publications

  1. ncbi Intracellular neutralization of HIV transcytosis across tight epithelial barriers by anti-HIV envelope protein dIgA or IgM
    M Bomsel
    U332 INSERM ICGM, Paris, France
    Immunity 9:277-87. 1998
  2. doi The adult penile urethra is a novel entry site for HIV-1 that preferentially targets resident urethral macrophages
    Y Ganor
    Department of Mucosal Entry of HIV 1 and Mucosal Immunity, Cell Biology, and Host Pathogen Interactions, Cochin Institute, INSERM, U1016, Paris, France
    Mucosal Immunol 6:776-86. 2013
  3. ncbi High-level ability of secretory IgA to block HIV type 1 transcytosis: contrasting secretory IgA and IgG responses to glycoprotein 160
    H Hocini
    Unité INSERM U430 Immunopathologie Humaine, Hopital Broussais, Paris, France
    AIDS Res Hum Retroviruses 13:1179-85. 1997
  4. doi HIV-1 gp41-specific monoclonal mucosal IgAs derived from highly exposed but IgG-seronegative individuals block HIV-1 epithelial transcytosis and neutralize CD4(+) cell infection: an IgA gene and functional analysis
    D Tudor
    Entrée Muqueuse du VIH et Immunité Muqueuse, Mucosal Entry of HIV 1 and Mucosal Immunity, Departement de Biologie Cellulaire, Cell Biology Department, Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    Mucosal Immunol 2:412-26. 2009
  5. doi Within 1 h, HIV-1 uses viral synapses to enter efficiently the inner, but not outer, foreskin mucosa and engages Langerhans-T cell conjugates
    Y Ganor
    Mucosal Entry of HIV 1 and Mucosal Immunity, Cell Biology and Host Pathogen Interactions Department, Cochin Institute, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    Mucosal Immunol 3:506-22. 2010
  6. ncbi Secretory IgA specific for a conserved epitope on gp41 envelope glycoprotein inhibits epithelial transcytosis of HIV-1
    A Alfsen
    , , Institut Cochin de Genetique Moleculaire, Paris, France
    J Immunol 166:6257-65. 2001
  7. ncbi Dictyostelium discoideum cells shed vesicles with associated DNA and vital stain Hoechst 33342
    I Tatischeff
    Laboratoire de Physicochimie Biomoleculaire et Cellulaire, CNRS URA 2056, Universite Pierre et Marie Curie, Paris, France
    Cell Mol Life Sci 54:476-87. 1998

Collaborators

  • H Hocini
  • L Belec
  • P Becquart
  • S Lagaye
  • C Desgranges
  • C Moog
  • Y Ganor
  • D Tudor
  • A Schmitt
  • M C Vacher-Lavenu
  • Z Zhou
  • A Alfsen
  • M Revol
  • D Mathez
  • J Leibowitch
  • J Bodo
  • N Thiounn
  • J P Wolf
  • L Gibault
  • J Tomasini
  • L Lopalco
  • M Houimel
  • J M Reynes
  • M Derrien
  • A S Drillet
  • L Diomede
  • I Tatischeff
  • E Bouguyon
  • P Iniguez
  • B Geny
  • H Durand
  • E Turpin
  • D Segretain
  • C de Paillerets

Detail Information

Publications7

  1. ncbi Intracellular neutralization of HIV transcytosis across tight epithelial barriers by anti-HIV envelope protein dIgA or IgM
    M Bomsel
    U332 INSERM ICGM, Paris, France
    Immunity 9:277-87. 1998
    ..These results suggest that induction of mucosal immunity to HIV envelope proteins may impair the transcytotic route of HIV mucosal transmission...
  2. doi The adult penile urethra is a novel entry site for HIV-1 that preferentially targets resident urethral macrophages
    Y Ganor
    Department of Mucosal Entry of HIV 1 and Mucosal Immunity, Cell Biology, and Host Pathogen Interactions, Cochin Institute, INSERM, U1016, Paris, France
    Mucosal Immunol 6:776-86. 2013
    ..Our results identify the male urethra as a novel entry site for HIV-1 that targets resident urethral macrophages. These results might explain the incomplete prophylactic efficacy of male circumcision in reducing HIV-1 transmission...
  3. ncbi High-level ability of secretory IgA to block HIV type 1 transcytosis: contrasting secretory IgA and IgG responses to glycoprotein 160
    H Hocini
    Unité INSERM U430 Immunopathologie Humaine, Hopital Broussais, Paris, France
    AIDS Res Hum Retroviruses 13:1179-85. 1997
    ..However, specific S-IgA was more efficient than IgG. These features suggest that mucosal specific S-IgA to HIV-1 could be relevant in decreasing infectivity of HIV-1 in corporal fluids...
  4. doi HIV-1 gp41-specific monoclonal mucosal IgAs derived from highly exposed but IgG-seronegative individuals block HIV-1 epithelial transcytosis and neutralize CD4(+) cell infection: an IgA gene and functional analysis
    D Tudor
    Entrée Muqueuse du VIH et Immunité Muqueuse, Mucosal Entry of HIV 1 and Mucosal Immunity, Departement de Biologie Cellulaire, Cell Biology Department, Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    Mucosal Immunol 2:412-26. 2009
    ..This analysis of HEPS monoclonal IgA gives a unique opportunity to correlate an antibody function (resistance to a pathogen in vivo) with an antibody gene. Such neutralizing monoclonal IgAs could be used in microbicide formulation...
  5. doi Within 1 h, HIV-1 uses viral synapses to enter efficiently the inner, but not outer, foreskin mucosa and engages Langerhans-T cell conjugates
    Y Ganor
    Mucosal Entry of HIV 1 and Mucosal Immunity, Cell Biology and Host Pathogen Interactions Department, Cochin Institute, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    Mucosal Immunol 3:506-22. 2010
    ..Seminal plasma mixed with cervicovaginal secretions inhibits HIV-1 translocation. This set of results rationalizes at the cellular level the apparent protective outcome of circumcision against HIV-1 acquisition by men...
  6. ncbi Secretory IgA specific for a conserved epitope on gp41 envelope glycoprotein inhibits epithelial transcytosis of HIV-1
    A Alfsen
    , , Institut Cochin de Genetique Moleculaire, Paris, France
    J Immunol 166:6257-65. 2001
    ..These results underscore the important role of secretory IgA in designing strategies for mucosal protection against HIV-1 infection...
  7. ncbi Dictyostelium discoideum cells shed vesicles with associated DNA and vital stain Hoechst 33342
    I Tatischeff
    Laboratoire de Physicochimie Biomoleculaire et Cellulaire, CNRS URA 2056, Universite Pierre et Marie Curie, Paris, France
    Cell Mol Life Sci 54:476-87. 1998
    ..Furthermore, since the association of DNA with vesicles occurs in physiological growth conditions and independently of vital staining, the new shedding process might be involved in a more general intercellular mechanism...