M Bomsel

Summary

Country: France

Publications

  1. ncbi Intracellular neutralization of HIV transcytosis across tight epithelial barriers by anti-HIV envelope protein dIgA or IgM
    M Bomsel
    U332 INSERM ICGM, Paris, France
    Immunity 9:277-87. 1998
  2. doi The adult penile urethra is a novel entry site for HIV-1 that preferentially targets resident urethral macrophages
    Y Ganor
    Department of Mucosal Entry of HIV 1 and Mucosal Immunity, Cell Biology, and Host Pathogen Interactions, Cochin Institute, INSERM, U1016, Paris, France
    Mucosal Immunol 6:776-86. 2013
  3. ncbi High-level ability of secretory IgA to block HIV type 1 transcytosis: contrasting secretory IgA and IgG responses to glycoprotein 160
    H Hocini
    Unité INSERM U430 Immunopathologie Humaine, Hopital Broussais, Paris, France
    AIDS Res Hum Retroviruses 13:1179-85. 1997
  4. doi HIV-1 gp41-specific monoclonal mucosal IgAs derived from highly exposed but IgG-seronegative individuals block HIV-1 epithelial transcytosis and neutralize CD4(+) cell infection: an IgA gene and functional analysis
    D Tudor
    Entrée Muqueuse du VIH et Immunité Muqueuse, Mucosal Entry of HIV 1 and Mucosal Immunity, Departement de Biologie Cellulaire, Cell Biology Department, Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    Mucosal Immunol 2:412-26. 2009
  5. doi Within 1 h, HIV-1 uses viral synapses to enter efficiently the inner, but not outer, foreskin mucosa and engages Langerhans-T cell conjugates
    Y Ganor
    Mucosal Entry of HIV 1 and Mucosal Immunity, Cell Biology and Host Pathogen Interactions Department, Cochin Institute, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    Mucosal Immunol 3:506-22. 2010
  6. ncbi Secretory IgA specific for a conserved epitope on gp41 envelope glycoprotein inhibits epithelial transcytosis of HIV-1
    A Alfsen
    , , Institut Cochin de Genetique Moleculaire, Paris, France
    J Immunol 166:6257-65. 2001
  7. doi Calcitonin gene-related peptide inhibits human immunodeficiency type 1 transmission by Langerhans cells via an autocrine/paracrine feedback mechanism
    Y Ganor
    Mucosal Entry of HIV 1 and Mucosal Immunity, Department of Infection, Immunity and Inflammation, Cochin Institute, CNRS UMR 8104, Paris, France INSERM U1016, Paris, France Paris Descartes University, Sorbonne Paris Cité, Paris, France
    Acta Physiol (Oxf) 213:432-41. 2015
  8. ncbi Dictyostelium discoideum cells shed vesicles with associated DNA and vital stain Hoechst 33342
    I Tatischeff
    Laboratoire de Physicochimie Biomoleculaire et Cellulaire, CNRS URA 2056, Universite Pierre et Marie Curie, Paris, France
    Cell Mol Life Sci 54:476-87. 1998

Collaborators

  • H Hocini
  • L Belec
  • P Becquart
  • S Lagaye
  • C Desgranges
  • C Moog
  • Y Ganor
  • D Tudor
  • Z Zhou
  • M C Vacher-Lavenu
  • A Schmitt
  • A Alfsen
  • A S Drillet-Dangeard
  • J Leibowitch
  • J Bodo
  • D Mathez
  • M Revol
  • J P Wolf
  • L Gibault
  • J Tomasini
  • N Thiounn
  • L Diomede
  • A S Drillet
  • L Lopalco
  • M Derrien
  • M Houimel
  • J M Reynes
  • I Tatischeff
  • E Bouguyon
  • P Iniguez
  • H Durand
  • C de Paillerets
  • B Geny
  • E Turpin
  • D Segretain

Detail Information

Publications8

  1. ncbi Intracellular neutralization of HIV transcytosis across tight epithelial barriers by anti-HIV envelope protein dIgA or IgM
    M Bomsel
    U332 INSERM ICGM, Paris, France
    Immunity 9:277-87. 1998
    ..These results suggest that induction of mucosal immunity to HIV envelope proteins may impair the transcytotic route of HIV mucosal transmission...
  2. doi The adult penile urethra is a novel entry site for HIV-1 that preferentially targets resident urethral macrophages
    Y Ganor
    Department of Mucosal Entry of HIV 1 and Mucosal Immunity, Cell Biology, and Host Pathogen Interactions, Cochin Institute, INSERM, U1016, Paris, France
    Mucosal Immunol 6:776-86. 2013
    ..Our results identify the male urethra as a novel entry site for HIV-1 that targets resident urethral macrophages. These results might explain the incomplete prophylactic efficacy of male circumcision in reducing HIV-1 transmission...
  3. ncbi High-level ability of secretory IgA to block HIV type 1 transcytosis: contrasting secretory IgA and IgG responses to glycoprotein 160
    H Hocini
    Unité INSERM U430 Immunopathologie Humaine, Hopital Broussais, Paris, France
    AIDS Res Hum Retroviruses 13:1179-85. 1997
    ..However, specific S-IgA was more efficient than IgG. These features suggest that mucosal specific S-IgA to HIV-1 could be relevant in decreasing infectivity of HIV-1 in corporal fluids...
  4. doi HIV-1 gp41-specific monoclonal mucosal IgAs derived from highly exposed but IgG-seronegative individuals block HIV-1 epithelial transcytosis and neutralize CD4(+) cell infection: an IgA gene and functional analysis
    D Tudor
    Entrée Muqueuse du VIH et Immunité Muqueuse, Mucosal Entry of HIV 1 and Mucosal Immunity, Departement de Biologie Cellulaire, Cell Biology Department, Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    Mucosal Immunol 2:412-26. 2009
    ..This analysis of HEPS monoclonal IgA gives a unique opportunity to correlate an antibody function (resistance to a pathogen in vivo) with an antibody gene. Such neutralizing monoclonal IgAs could be used in microbicide formulation...
  5. doi Within 1 h, HIV-1 uses viral synapses to enter efficiently the inner, but not outer, foreskin mucosa and engages Langerhans-T cell conjugates
    Y Ganor
    Mucosal Entry of HIV 1 and Mucosal Immunity, Cell Biology and Host Pathogen Interactions Department, Cochin Institute, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    Mucosal Immunol 3:506-22. 2010
    ..Seminal plasma mixed with cervicovaginal secretions inhibits HIV-1 translocation. This set of results rationalizes at the cellular level the apparent protective outcome of circumcision against HIV-1 acquisition by men...
  6. ncbi Secretory IgA specific for a conserved epitope on gp41 envelope glycoprotein inhibits epithelial transcytosis of HIV-1
    A Alfsen
    , , Institut Cochin de Genetique Moleculaire, Paris, France
    J Immunol 166:6257-65. 2001
    ..These results underscore the important role of secretory IgA in designing strategies for mucosal protection against HIV-1 infection...
  7. doi Calcitonin gene-related peptide inhibits human immunodeficiency type 1 transmission by Langerhans cells via an autocrine/paracrine feedback mechanism
    Y Ganor
    Mucosal Entry of HIV 1 and Mucosal Immunity, Department of Infection, Immunity and Inflammation, Cochin Institute, CNRS UMR 8104, Paris, France INSERM U1016, Paris, France Paris Descartes University, Sorbonne Paris Cité, Paris, France
    Acta Physiol (Oxf) 213:432-41. 2015
    ..Herein, we investigated the anti-HIV-1 mechanism of CGRP...
  8. ncbi Dictyostelium discoideum cells shed vesicles with associated DNA and vital stain Hoechst 33342
    I Tatischeff
    Laboratoire de Physicochimie Biomoleculaire et Cellulaire, CNRS URA 2056, Universite Pierre et Marie Curie, Paris, France
    Cell Mol Life Sci 54:476-87. 1998
    ..Furthermore, since the association of DNA with vesicles occurs in physiological growth conditions and independently of vital staining, the new shedding process might be involved in a more general intercellular mechanism...