Vranic S, Shimada Y, Ichihara S, Kimata M, Wu W, Tanaka T, et al
. Toxicological Evaluation of SiO₂ Nanoparticles by Zebrafish Embryo Toxicity Test. Int J Mol Sci. 2019;20: pubmed publisher
..These results indicate that zebrafish chorion acts as a physical barrier against SiO₂ NPs, and removing the chorions in ZFET might be necessary for evaluation of toxicity of NPs. ..
Wakx A, Nedder M, Tomkiewicz Raulet C, Dalmasso J, Chissey A, Boland S, et al
. Expression, Localization, and Activity of the Aryl Hydrocarbon Receptor in the Human Placenta. Int J Mol Sci. 2018;19: pubmed publisher
..Our data suggest an intrinsic activation of AhR due to the presence of endogenous placental ligands. ..
George I, Vranic S, Boland S, Courtois A, Baeza Squiban A. Development of an in vitro model of human bronchial epithelial barrier to study nanoparticle translocation. Toxicol In Vitro. 2015;29:51-8 pubmed publisher
..In conclusion, 50 nm-SiO(2)-FITC-NPs can cross different bronchial epithelial barriers, but the Calu-3 cell line appears to be the most relevant model for studying NP translocation. ..
Vranic S, Gosens I, Jacobsen N, Jensen K, Bokkers B, Kermanizadeh A, et al
. Impact of serum as a dispersion agent for in vitro and in vivo toxicological assessments of TiO2 nanoparticles. Arch Toxicol. 2017;91:353-363 pubmed publisher
..To avoid potential unwanted effects of dispersants and medium components, we recommend that the protocol of NM preparation should be thoroughly tested, and reflect as close as possible realistic exposure conditions. ..
Delaval M, Wohlleben W, Landsiedel R, Baeza Squiban A, Boland S. Assessment of the oxidative potential of nanoparticles by the cytochrome c assay: assay improvement and development of a high-throughput method to predict the toxicity of nanoparticles. Arch Toxicol. 2017;91:163-177 pubmed publisher
..However, acellular redox assays may not be sufficient to discriminate among low-toxicity NPs, and additional tests are thus needed. ..
Delaval M, Boland S, Solhonne B, Nicola M, Mornet S, Baeza Squiban A, et al
. Acute exposure to silica nanoparticles enhances mortality and increases lung permeability in a mouse model of Pseudomonas aeruginosa pneumonia. Part Fibre Toxicol. 2015;12:1 pubmed publisher
..The deleterious effects of SiO2 nanoparticle exposure during Pseudomonas aeruginosa-induced pneumonia are related to alterations of the alveolar-capillary barrier rather than to modulation of the inflammatory responses. ..