Joel Bockaert

Summary

Country: France

Publications

  1. ncbi GPCR-GIP networks: a first step in the discovery of new therapeutic drugs?
    Joel Bockaert
    Laboratoire de Génomique Fonctionnelle, UPR CNRS 2580, 34094 Montpellier Cedex 5, France
    Curr Opin Drug Discov Devel 7:649-57. 2004
  2. ncbi GPCR interacting proteins (GIP)
    Joel Bockaert
    UPR CNRS 2580, CCIPE, 141 rue de la Cardonille, 34094 Montpellier Cedex 5, France
    Pharmacol Ther 103:203-21. 2004
  3. ncbi The 'magic tail' of G protein-coupled receptors: an anchorage for functional protein networks
    Joel Bockaert
    Laboratoire de Génomique Fonctionnelle, UPR CNRS 2580, 141 rue de la Cardonille, 34094 Montpellier Cedex 5, France
    FEBS Lett 546:65-72. 2003
  4. ncbi 5-HT4 receptors
    J Bockaert
    UPR CNRS 2580 CCIPE, 141 rue de la Cardonille, 34094 Montpellier Cedex 5, France
    Curr Drug Targets CNS Neurol Disord 3:39-51. 2004
  5. pmc GLP-1 mediates antiapoptotic effect by phosphorylating Bad through a beta-arrestin 1-mediated ERK1/2 activation in pancreatic beta-cells
    Julie Quoyer
    INSERM, U661, Equipe Avenir, CNRS, UMR5203, Institut de Genomique Fonctionnelle, Université Montpellier I and II, 34094 Montpellier Cedex 5, France
    J Biol Chem 285:1989-2002. 2010
  6. ncbi Homer-dependent cell surface expression of metabotropic glutamate receptor type 5 in neurons
    Fabrice Ango
    UPR CNRS 9023, CCIPE, 141 rue de la Cardonille, 34094 Montpellier, France
    Mol Cell Neurosci 20:323-9. 2002
  7. ncbi New sorting nexin (SNX27) and NHERF specifically interact with the 5-HT4a receptor splice variant: roles in receptor targeting
    Lara Joubert
    Laboratoire de Génomique Fonctionnelle, CNRS UPR2580, CCIPE, 141 rue de la Cardonille, 34094 Montpellier Cedex 05, France
    J Cell Sci 117:5367-79. 2004
  8. doi beta-Arrestin 1 is required for PAC1 receptor-mediated potentiation of long-lasting ERK1/2 activation by glucose in pancreatic beta-cells
    Christophe Broca
    Institut de Genomique Fonctionnelle, CNRS, Unite Mixte de Recherche 5203, INSERM, U661, Universite Montpellier I, and Université Montpellier II, 34094 Montpellier Cedex 5, France
    J Biol Chem 284:4332-42. 2009
  9. ncbi Molecular and functional characterization of proteins interacting with the C-terminal domains of 5-HT2 receptors: emergence of 5-HT2 "receptosomes"
    Sophie Gavarini
    UPR CNRS 2580, 141 rue de la Cardonille, 34094 Montpellier Cedex 5, France
    Biol Cell 96:373-81. 2004
  10. ncbi A single mutation in the 5-HT4 receptor (5-HT4-R D100(3.32)A) generates a Gs-coupled receptor activated exclusively by synthetic ligands (RASSL)
    Sylvie Claeysen
    Centre National de la Recherche Scientifique, UPR 9023, 141 rue de la Cardonille, 34094 Montpellier, Cedex 5, France
    J Biol Chem 278:699-702. 2003

Collaborators

Detail Information

Publications27

  1. ncbi GPCR-GIP networks: a first step in the discovery of new therapeutic drugs?
    Joel Bockaert
    Laboratoire de Génomique Fonctionnelle, UPR CNRS 2580, 34094 Montpellier Cedex 5, France
    Curr Opin Drug Discov Devel 7:649-57. 2004
    ..Finally, we discuss the possibilities for developing new therapeutic drugs capable of modulating GPCR signaling by disrupting or reinforcing specific GPCR-GIP interactions...
  2. ncbi GPCR interacting proteins (GIP)
    Joel Bockaert
    UPR CNRS 2580, CCIPE, 141 rue de la Cardonille, 34094 Montpellier Cedex 5, France
    Pharmacol Ther 103:203-21. 2004
    ..Finally, only few GIPs have been found thus far to interact with the third intracellular loop of GPCRs. The future will tell us if this situation is only due to technical reasons...
  3. ncbi The 'magic tail' of G protein-coupled receptors: an anchorage for functional protein networks
    Joel Bockaert
    Laboratoire de Génomique Fonctionnelle, UPR CNRS 2580, 141 rue de la Cardonille, 34094 Montpellier Cedex 5, France
    FEBS Lett 546:65-72. 2003
    ..To date, proteins that interact with the GPCR C-terminus are the most abundant and are the focus of this review...
  4. ncbi 5-HT4 receptors
    J Bockaert
    UPR CNRS 2580 CCIPE, 141 rue de la Cardonille, 34094 Montpellier Cedex 5, France
    Curr Drug Targets CNS Neurol Disord 3:39-51. 2004
    ..One 5-HT(4)R-directed drug (SL65.0155) is already in phase II to treat patients suffering from memory deficits or dementia...
  5. pmc GLP-1 mediates antiapoptotic effect by phosphorylating Bad through a beta-arrestin 1-mediated ERK1/2 activation in pancreatic beta-cells
    Julie Quoyer
    INSERM, U661, Equipe Avenir, CNRS, UMR5203, Institut de Genomique Fonctionnelle, Université Montpellier I and II, 34094 Montpellier Cedex 5, France
    J Biol Chem 285:1989-2002. 2010
    ..Such signaling mechanism may serve as a prototype to generate new therapeutic GLP-1R ligands...
  6. ncbi Homer-dependent cell surface expression of metabotropic glutamate receptor type 5 in neurons
    Fabrice Ango
    UPR CNRS 9023, CCIPE, 141 rue de la Cardonille, 34094 Montpellier, France
    Mol Cell Neurosci 20:323-9. 2002
    ..These results indicate that Homer1 proteins regulate synaptic cycling and Ca2+ signaling of mGlu5 receptors, in response to neuronal activity...
  7. ncbi New sorting nexin (SNX27) and NHERF specifically interact with the 5-HT4a receptor splice variant: roles in receptor targeting
    Lara Joubert
    Laboratoire de Génomique Fonctionnelle, CNRS UPR2580, CCIPE, 141 rue de la Cardonille, 34094 Montpellier Cedex 05, France
    J Cell Sci 117:5367-79. 2004
    ..The interaction of the 5-HT4R splice variants with distinct sets of PDZ proteins might specify their cellular localization as well as their signal transduction properties...
  8. doi beta-Arrestin 1 is required for PAC1 receptor-mediated potentiation of long-lasting ERK1/2 activation by glucose in pancreatic beta-cells
    Christophe Broca
    Institut de Genomique Fonctionnelle, CNRS, Unite Mixte de Recherche 5203, INSERM, U661, Universite Montpellier I, and Université Montpellier II, 34094 Montpellier Cedex 5, France
    J Biol Chem 284:4332-42. 2009
    ....
  9. ncbi Molecular and functional characterization of proteins interacting with the C-terminal domains of 5-HT2 receptors: emergence of 5-HT2 "receptosomes"
    Sophie Gavarini
    UPR CNRS 2580, 141 rue de la Cardonille, 34094 Montpellier Cedex 5, France
    Biol Cell 96:373-81. 2004
    ..Data indicating that the protein complexes interacting with 5-HT(2) receptor C-termini tightly control receptor trafficking and receptor-mediated signalling will also be reviewed...
  10. ncbi A single mutation in the 5-HT4 receptor (5-HT4-R D100(3.32)A) generates a Gs-coupled receptor activated exclusively by synthetic ligands (RASSL)
    Sylvie Claeysen
    Centre National de la Recherche Scientifique, UPR 9023, 141 rue de la Cardonille, 34094 Montpellier, Cedex 5, France
    J Biol Chem 278:699-702. 2003
    ..More interestingly, two synthetic ligands behave as antagonists on the wild type but as agonists on the 5-HT(4)-RASSL...
  11. doi Calcineurin interacts with the serotonin transporter C-terminus to modulate its plasma membrane expression and serotonin uptake
    Mathieu Seimandi
    Centre National de la Recherche Scientifique, UMR 5203, Institut de Genomique Fonctionnelle, F 34094 Montpellier, France, Institut National de la Sante et de la Recherche Medicale, U661, F 34094 Montpellier, France, Universite Montpellier 1, F 34094 Montpellier, France, Universite Montpellier 2, F 34094 Montpellier, France, and Brain Research Institute, Medical Faculty of the University of Zürich and Department of Health Science and Technology of the Swiss Federal Institute of Technology, CH 8057 Zurich, Switzerland
    J Neurosci 33:16189-99. 2013
    ....
  12. ncbi Inverse agonist and neutral antagonist actions of antidepressants at recombinant and native 5-hydroxytryptamine2C receptors: differential modulation of cell surface expression and signal transduction
    Benjamin Chanrion
    Institut de Genomique Fonctionnelle, Universités de Montpellier, CNRS UMRS 5203, INSERM U661, 141 rue de la Cardonille, F 34094 Montpellier Cedex 5, France
    Mol Pharmacol 73:748-57. 2008
    ..The clinical significance of inverse agonist versus neutral antagonist properties both during and after drug administration will be of interest to elucidate...
  13. pmc PICK1 uncoupling from mGluR7a causes absence-like seizures
    Federica Bertaso
    CNRS UMR5203, Institut de Genomique Fonctionnelle, Montpellier, France, INSERM, U661, Montpellier, France and Université Montpellier, 1, 2, 141 Rue de Cardonille, 34094 Montpellier, Cedex 5, France
    Nat Neurosci 11:940-8. 2008
    ....
  14. ncbi Difference in mass analysis using labeled lysines (DIMAL-K): a new, efficient proteomic quantification method applied to the analysis of astrocytic secretomes
    Nicolas Delcourt
    département de neurobiologie, Institut de Genomique Fonctionnelle, 141 rue de la Cardonille, 34094 Montpellier Cedex 5, France
    Mol Cell Proteomics 4:1085-94. 2005
    ..We showed that DIMAL-K was more sensitive and accurate than densitometric image analysis and allowed the detection and quantification of novel proteins...
  15. ncbi Proteomic analysis of astrocytic secretion in the mouse. Comparison with the cerebrospinal fluid proteome
    Mireille Lafon-Cazal
    Unité Propre CNRS 2580, 141 rue de la Cardonille, 34094 Montpellier Cedex 5, France
    J Biol Chem 278:24438-48. 2003
    ..In conclusion, this study provides the first unbiased characterization of the major proteins released by astrocytes, which may play a crucial role in the modulation of neuronal survival and function...
  16. doi β-Arrestin2 plays a key role in the modulation of the pancreatic beta cell mass in mice
    Magalie A Ravier
    CNRS, UMR 5203, Institut de Genomique Fonctionnelle, 141 rue de la Cardonille, 34094, Montpellier, France
    Diabetologia 57:532-41. 2014
    ....
  17. ncbi Increased number of neural progenitors in human temporal lobe epilepsy
    Arielle Crespel
    Institut de Genomique Fonctionnelle, CNRS UMR 5023 INSERM U661, UM1 UM2, 141 rue de la Cardonille, F 34094 Montpellier Cedex 5, France
    Neurobiol Dis 19:436-50. 2005
    ..These findings demonstrate that neural progenitors proliferate in chronic epilepsy and suggest that the fissura hippocampi behaves like another neurogenic area...
  18. ncbi Metabotropic glutamate receptor 2/3-dependent long-term depression in the nucleus accumbens is blocked in morphine withdrawn mice
    David Robbe
    CNRS UPR 9023, 141 rue de la Cardonille, 34094 Montpellier Cedex 05, France
    Eur J Neurosci 16:2231-5. 2002
    ....
  19. ncbi Transcription of the mouse PAC1 receptor gene: cell-specific expression and regulation by Zac1
    Nieves Rodriguez-Henche
    CNRS UPR 9023, 141 rue de la Cardonille, 34094 Montpellier Cedex 5, France
    Biochim Biophys Acta 1576:157-62. 2002
    ..Our findings provide bases for future studies on the regulatory elements controlling PAC1 gene transcription and demonstrate the PAC1 receptor promoter as a target of Zac1...
  20. ncbi 5-HT receptor-associated protein networks: new targets for drug discovery in psychiatric disorders?
    Philippe Marin
    Institut de Genomique Fonctionnelle, 141 rue de la Cardonille, Montpellier F 34094 Montpellier Cedex 5, France
    Curr Drug Targets 13:28-52. 2012
    ....
  21. ncbi Dynamic reorganization of the astrocyte actin cytoskeleton elicited by cAMP and PACAP: a role for phosphatidylInositol 3-kinase inhibition
    Virgili Perez
    UPR 2580 CNRS, Laboratoire de Génomique Fonctionnelle, 141, rue de la Cardonille, 34094 Montpellier Cedex 05, France
    Eur J Neurosci 21:26-32. 2005
    ..Together, these data demonstrate for the first time that depolymerization of stress fibres, and the resulting astrocyte stellation, induced by stimulation of cAMP production involves the inhibition of the PI 3-K-RhoA pathway...
  22. ncbi Identification and functional roles of metabotropic glutamate receptor-interacting proteins
    Laurent Fagni
    Laboratory of Functional Genomics, CNRS UPR 2580, CCIPE, 141 rue de la Cardonille, 34094 Montpellier Cedex 05, France
    Semin Cell Dev Biol 15:289-98. 2004
    ..Here we will focus on those proteins that interact with the subgroup of metabotropic glutamate (mGlu) receptors, and review the methods used for their identification, as well as their functional roles in neurons...
  23. ncbi The serotonin 5-HT2A and 5-HT2C receptors interact with specific sets of PDZ proteins
    Carine Becamel
    UPR CNRS 2580 and CNRS UMR 5101, 141 rue de la Cardonille, 34094 Montpellier Cedex 5, France
    J Biol Chem 279:20257-66. 2004
    ..The interaction of the 5-HT(2A) and the 5-HT(2C) receptor with specific sets of PDZ proteins may contribute to their different signal transduction properties...
  24. ncbi ERK1/2 control phosphorylation and protein level of cAMP-responsive element-binding protein: a key role in glucose-mediated pancreatic beta-cell survival
    Safia Costes
    INSERM U661, Equipe Avenir, Institut de Genomique Fonctionnelle, 141, rue de la Cardonille, 34094 Montpellier Cedex 5, France
    Diabetes 55:2220-30. 2006
    ..Our results indicate that ERK1 and -2 control the phosphorylation and protein level of CREB and play a key role in glucose-mediated pancreatic beta-cell survival...
  25. ncbi GPCR-jacking: from a new route in RTK signalling to a new concept in GPCR activation
    Nicolas Delcourt
    Institut de Genomique Fonctionnelle, Universités de Montpellier, CNRS UMR 5203, 141 rue de la Cardonille, Montpellier Cedex 5, F 34094, France
    Trends Pharmacol Sci 28:602-7. 2007
    ..Here, we provide an overview of the molecular mechanisms involved in this novel cross-communication between GPCRs and RTKs and discuss its relevance in the specification of growth factor signalling and functions...
  26. ncbi [Feeding disorders in 5-HT4 receptor knockout mice]
    Valérie Compan
    Laboratoire de Génomique Fonctionnelle, UPR CNRS 2580, 141 rue de la Cardonille, 34094 Montpellier
    J Soc Biol 198:37-49. 2004
    ....
  27. ncbi The Drosophila metabotropic glutamate receptor DmGluRA regulates activity-dependent synaptic facilitation and fine synaptic morphology
    Laurent Bogdanik
    Laboratoire de Génomique Fonctionnelle, Centre National de la Recherche Scientifique, Unite Propre de Recherche 2580, 34094 Montpellier Cedex 05, France
    J Neurosci 24:9105-16. 2004
    ....