Joel Bockaert

Summary

Country: France

Publications

  1. ncbi GPCR-GIP networks: a first step in the discovery of new therapeutic drugs?
    Joel Bockaert
    Laboratoire de Génomique Fonctionnelle, UPR CNRS 2580, 34094 Montpellier Cedex 5, France
    Curr Opin Drug Discov Devel 7:649-57. 2004
  2. ncbi The 'magic tail' of G protein-coupled receptors: an anchorage for functional protein networks
    Joel Bockaert
    Laboratoire de Génomique Fonctionnelle, UPR CNRS 2580, 141 rue de la Cardonille, 34094 Montpellier Cedex 5, France
    FEBS Lett 546:65-72. 2003
  3. ncbi 5-HT4 receptors
    J Bockaert
    UPR CNRS 2580 CCIPE, 141 rue de la Cardonille, 34094 Montpellier Cedex 5, France
    Curr Drug Targets CNS Neurol Disord 3:39-51. 2004
  4. ncbi GPCR interacting proteins (GIP)
    Joel Bockaert
    UPR CNRS 2580, CCIPE, 141 rue de la Cardonille, 34094 Montpellier Cedex 5, France
    Pharmacol Ther 103:203-21. 2004
  5. ncbi GLP-1 mediates antiapoptotic effect by phosphorylating Bad through a beta-arrestin 1-mediated ERK1/2 activation in pancreatic beta-cells
    Julie Quoyer
    INSERM, U661, Equipe Avenir, CNRS, UMR5203, Institut de Genomique Fonctionnelle, Université Montpellier I and II, 34094 Montpellier Cedex 5, France
    J Biol Chem 285:1989-2002. 2010
  6. ncbi beta-Arrestin 1 is required for PAC1 receptor-mediated potentiation of long-lasting ERK1/2 activation by glucose in pancreatic beta-cells
    Christophe Broca
    Institut de Genomique Fonctionnelle, CNRS, Unite Mixte de Recherche 5203, INSERM, U661, Universite Montpellier I, and Université Montpellier II, 34094 Montpellier Cedex 5, France
    J Biol Chem 284:4332-42. 2009
  7. ncbi New sorting nexin (SNX27) and NHERF specifically interact with the 5-HT4a receptor splice variant: roles in receptor targeting
    Lara Joubert
    Laboratoire de Génomique Fonctionnelle, CNRS UPR2580, CCIPE, 141 rue de la Cardonille, 34094 Montpellier Cedex 05, France
    J Cell Sci 117:5367-79. 2004
  8. ncbi Inverse agonist and neutral antagonist actions of antidepressants at recombinant and native 5-hydroxytryptamine2C receptors: differential modulation of cell surface expression and signal transduction
    Benjamin Chanrion
    Institut de Genomique Fonctionnelle, Universités de Montpellier, CNRS UMRS 5203, INSERM U661, 141 rue de la Cardonille, F 34094 Montpellier Cedex 5, France
    Mol Pharmacol 73:748-57. 2008
  9. ncbi PICK1 uncoupling from mGluR7a causes absence-like seizures
    Federica Bertaso
    CNRS UMR5203, Institut de Genomique Fonctionnelle, Montpellier, France, INSERM, U661, Montpellier, France and Université Montpellier, 1, 2, 141 Rue de Cardonille, 34094 Montpellier, Cedex 5, France
    Nat Neurosci 11:940-8. 2008
  10. ncbi Transcription of the mouse PAC1 receptor gene: cell-specific expression and regulation by Zac1
    Nieves Rodriguez-Henche
    CNRS UPR 9023, 141 rue de la Cardonille, 34094 Montpellier Cedex 5, France
    Biochim Biophys Acta 1576:157-62. 2002

Collaborators

Detail Information

Publications18

  1. ncbi GPCR-GIP networks: a first step in the discovery of new therapeutic drugs?
    Joel Bockaert
    Laboratoire de Génomique Fonctionnelle, UPR CNRS 2580, 34094 Montpellier Cedex 5, France
    Curr Opin Drug Discov Devel 7:649-57. 2004
    ..Finally, we discuss the possibilities for developing new therapeutic drugs capable of modulating GPCR signaling by disrupting or reinforcing specific GPCR-GIP interactions...
  2. ncbi The 'magic tail' of G protein-coupled receptors: an anchorage for functional protein networks
    Joel Bockaert
    Laboratoire de Génomique Fonctionnelle, UPR CNRS 2580, 141 rue de la Cardonille, 34094 Montpellier Cedex 5, France
    FEBS Lett 546:65-72. 2003
    ..To date, proteins that interact with the GPCR C-terminus are the most abundant and are the focus of this review...
  3. ncbi 5-HT4 receptors
    J Bockaert
    UPR CNRS 2580 CCIPE, 141 rue de la Cardonille, 34094 Montpellier Cedex 5, France
    Curr Drug Targets CNS Neurol Disord 3:39-51. 2004
    ..One 5-HT(4)R-directed drug (SL65.0155) is already in phase II to treat patients suffering from memory deficits or dementia...
  4. ncbi GPCR interacting proteins (GIP)
    Joel Bockaert
    UPR CNRS 2580, CCIPE, 141 rue de la Cardonille, 34094 Montpellier Cedex 5, France
    Pharmacol Ther 103:203-21. 2004
    ..Finally, only few GIPs have been found thus far to interact with the third intracellular loop of GPCRs. The future will tell us if this situation is only due to technical reasons...
  5. ncbi GLP-1 mediates antiapoptotic effect by phosphorylating Bad through a beta-arrestin 1-mediated ERK1/2 activation in pancreatic beta-cells
    Julie Quoyer
    INSERM, U661, Equipe Avenir, CNRS, UMR5203, Institut de Genomique Fonctionnelle, Université Montpellier I and II, 34094 Montpellier Cedex 5, France
    J Biol Chem 285:1989-2002. 2010
    ..Such signaling mechanism may serve as a prototype to generate new therapeutic GLP-1R ligands...
  6. ncbi beta-Arrestin 1 is required for PAC1 receptor-mediated potentiation of long-lasting ERK1/2 activation by glucose in pancreatic beta-cells
    Christophe Broca
    Institut de Genomique Fonctionnelle, CNRS, Unite Mixte de Recherche 5203, INSERM, U661, Universite Montpellier I, and Université Montpellier II, 34094 Montpellier Cedex 5, France
    J Biol Chem 284:4332-42. 2009
    ....
  7. ncbi New sorting nexin (SNX27) and NHERF specifically interact with the 5-HT4a receptor splice variant: roles in receptor targeting
    Lara Joubert
    Laboratoire de Génomique Fonctionnelle, CNRS UPR2580, CCIPE, 141 rue de la Cardonille, 34094 Montpellier Cedex 05, France
    J Cell Sci 117:5367-79. 2004
    ..The interaction of the 5-HT4R splice variants with distinct sets of PDZ proteins might specify their cellular localization as well as their signal transduction properties...
  8. ncbi Inverse agonist and neutral antagonist actions of antidepressants at recombinant and native 5-hydroxytryptamine2C receptors: differential modulation of cell surface expression and signal transduction
    Benjamin Chanrion
    Institut de Genomique Fonctionnelle, Universités de Montpellier, CNRS UMRS 5203, INSERM U661, 141 rue de la Cardonille, F 34094 Montpellier Cedex 5, France
    Mol Pharmacol 73:748-57. 2008
    ..The clinical significance of inverse agonist versus neutral antagonist properties both during and after drug administration will be of interest to elucidate...
  9. ncbi PICK1 uncoupling from mGluR7a causes absence-like seizures
    Federica Bertaso
    CNRS UMR5203, Institut de Genomique Fonctionnelle, Montpellier, France, INSERM, U661, Montpellier, France and Université Montpellier, 1, 2, 141 Rue de Cardonille, 34094 Montpellier, Cedex 5, France
    Nat Neurosci 11:940-8. 2008
    ....
  10. ncbi Transcription of the mouse PAC1 receptor gene: cell-specific expression and regulation by Zac1
    Nieves Rodriguez-Henche
    CNRS UPR 9023, 141 rue de la Cardonille, 34094 Montpellier Cedex 5, France
    Biochim Biophys Acta 1576:157-62. 2002
    ..Our findings provide bases for future studies on the regulatory elements controlling PAC1 gene transcription and demonstrate the PAC1 receptor promoter as a target of Zac1...
  11. ncbi 5-HT receptor-associated protein networks: new targets for drug discovery in psychiatric disorders?
    Philippe Marin
    Institut de Genomique Fonctionnelle, 141 rue de la Cardonille, Montpellier F 34094 Montpellier Cedex 5, France
    Curr Drug Targets 13:28-52. 2012
    ....
  12. ncbi Dynamic reorganization of the astrocyte actin cytoskeleton elicited by cAMP and PACAP: a role for phosphatidylInositol 3-kinase inhibition
    Virgili Perez
    UPR 2580 CNRS, Laboratoire de Génomique Fonctionnelle, 141, rue de la Cardonille, 34094 Montpellier Cedex 05, France
    Eur J Neurosci 21:26-32. 2005
    ..Together, these data demonstrate for the first time that depolymerization of stress fibres, and the resulting astrocyte stellation, induced by stimulation of cAMP production involves the inhibition of the PI 3-K-RhoA pathway...
  13. ncbi Identification and functional roles of metabotropic glutamate receptor-interacting proteins
    Laurent Fagni
    Laboratory of Functional Genomics, CNRS UPR 2580, CCIPE, 141 rue de la Cardonille, 34094 Montpellier Cedex 05, France
    Semin Cell Dev Biol 15:289-98. 2004
    ..Here we will focus on those proteins that interact with the subgroup of metabotropic glutamate (mGlu) receptors, and review the methods used for their identification, as well as their functional roles in neurons...
  14. ncbi The serotonin 5-HT2A and 5-HT2C receptors interact with specific sets of PDZ proteins
    Carine Becamel
    UPR CNRS 2580 and CNRS UMR 5101, 141 rue de la Cardonille, 34094 Montpellier Cedex 5, France
    J Biol Chem 279:20257-66. 2004
    ..The interaction of the 5-HT(2A) and the 5-HT(2C) receptor with specific sets of PDZ proteins may contribute to their different signal transduction properties...
  15. ncbi ERK1/2 control phosphorylation and protein level of cAMP-responsive element-binding protein: a key role in glucose-mediated pancreatic beta-cell survival
    Safia Costes
    INSERM U661, Equipe Avenir, Institut de Genomique Fonctionnelle, 141, rue de la Cardonille, 34094 Montpellier Cedex 5, France
    Diabetes 55:2220-30. 2006
    ..Our results indicate that ERK1 and -2 control the phosphorylation and protein level of CREB and play a key role in glucose-mediated pancreatic beta-cell survival...
  16. ncbi GPCR-jacking: from a new route in RTK signalling to a new concept in GPCR activation
    Nicolas Delcourt
    Institut de Genomique Fonctionnelle, Universités de Montpellier, CNRS UMR 5203, 141 rue de la Cardonille, Montpellier Cedex 5, F 34094, France
    Trends Pharmacol Sci 28:602-7. 2007
    ..Here, we provide an overview of the molecular mechanisms involved in this novel cross-communication between GPCRs and RTKs and discuss its relevance in the specification of growth factor signalling and functions...
  17. ncbi The Drosophila metabotropic glutamate receptor DmGluRA regulates activity-dependent synaptic facilitation and fine synaptic morphology
    Laurent Bogdanik
    Laboratoire de Génomique Fonctionnelle, Centre National de la Recherche Scientifique, Unite Propre de Recherche 2580, 34094 Montpellier Cedex 05, France
    J Neurosci 24:9105-16. 2004
    ....
  18. ncbi [Feeding disorders in 5-HT4 receptor knockout mice]
    Valérie Compan
    Laboratoire de Génomique Fonctionnelle, UPR CNRS 2580, 141 rue de la Cardonille, 34094 Montpellier
    J Soc Biol 198:37-49. 2004
    ....