Mohamed Bnouham

Summary

Affiliation: Faculty of Sciences. University Mohamed first
Location: Oujda, Morocco
Publications:
1. Artemisia herba-alba Asso relaxes the rat aorta through activation of NO/cGMP pathway and K(ATP) channels.

Skiker M, Mekhfi H, Aziz M, Haloui B, Lahlou S, Legssyer A, Bnouham M, Ziyyat A.

J Smooth Muscle Res. 2010;46(3):165-74.

2. Anti-diarrhoeal activity of crude aqueous extract of Rubia tinctorum L. roots in rodents.

Karim A, Mekhfi H, Ziyyat A, Legssyer A, Bnouham M, Amrani S, Atmani F, Melhaoui A, Aziz M.

J Smooth Muscle Res. 2010;46(2):119-23.

3. Antidiabetic medicinal plants as a source of alpha glucosidase inhibitors.

Benalla W, Bellahcen S, Bnouham M.

Curr Diabetes Rev. 2010 Jul 1;6(4):247-54. Review.

4. Antidiabetic effect of some medicinal plants of Oriental Morocco in neonatal non-insulin-dependent diabetes mellitus rats.

Bnouham M, Merhfour FZ, Ziyyat A, Aziz M, Legssyer A, Mekhfi H.

Hum Exp Toxicol. 2010 Oct;29(10):865-71. Epub 2010 Feb 12.

5. Antihypertensive and endothelium-dependent vasodilator effects of aqueous extract of Cistus ladaniferus.

Belmokhtar M, Bouanani NE, Ziyyat A, Mekhfi H, Bnouham M, Aziz M, Matéo P, Fischmeister R, Legssyer A.

Biochem Biophys Res Commun. 2009 Nov 6;389(1):145-9. Epub 2009 Aug 26.

6. Parsley extract inhibits in vitro and ex vivo platelet aggregation and prolongs bleeding time in rats.

Gadi D, Bnouham M, Aziz M, Ziyyat A, Legssyer A, Legrand C, Lafeve FF, Mekhfi H.

J Ethnopharmacol. 2009 Aug 17;125(1):170-4. Epub 2009 May 23.

7. Arbutus unedo prevents cardiovascular and morphological alterations in L-NAME-induced hypertensive rats Part I: cardiovascular and renal hemodynamic effects of Arbutus unedo in L-NAME-induced hypertensive rats.

Afkir S, Nguelefack TB, Aziz M, Zoheir J, Cuisinaud G, Bnouham M, Mekhfi H, Legssyer A, Lahlou S, Ziyyat A.

J Ethnopharmacol. 2008 Mar 5;116(2):288-95. Epub 2007 Nov 26.

8. Antihyperglycemic activity of Arbutus unedo, Ammoides pusilla and Thymelaea hirsuta.

Bnouham M, Merhfour FZ, Legssyer A, Mekhfi H, Maâllem S, Ziyyat A.

Pharmazie. 2007 Aug;62(8):630-2.

9. Relaxant effect of aqueous extract of Cistus ladaniferus on rodent intestinal contractions.

Aziz M, Tab N, Karim A, Mekhfi H, Bnouham M, Ziyyat A, Melhaoui A, Legssyer A.

Fitoterapia. 2006 Sep;77(6):425-8. Epub 2006 May 24.

10. Inhibition of rat platelet aggregation by Urtica dioica leaves extracts.

El Haouari M, Bnouham M, Bendahou M, Aziz M, Ziyyat A, Legssyer A, Mekhfi H.

Phytother Res. 2006 Jul;20(7):568-72.

11. Effects of extracts and tannins from Arbutus unedo leaves on rat platelet aggregation.

Mekhfi H, ElHaouari M, Bnouham M, Aziz M, Ziyyat A, Legssyer A.

Phytother Res. 2006 Feb;20(2):135-9.

12. Tannins and catechin gallate mediate the vasorelaxant effect of Arbutus unedo on the rat isolated aorta.

Legssyer A, Ziyyat A, Mekh H, Bnouham M, Herrenknecht C, Roumy V, Fourneau C, Laurens A, Hoerter J, Fischmeister R.

Phytother Res. 2004 Nov;18(11):889-94.

13. Platelet anti-aggregant property of some Moroccan medicinal plants.

Mekhfi H, El Haouari M, Legssyer A, Bnouham M, Aziz M, Atmani F, Remmal A, Ziyyat A.

J Ethnopharmacol. 2004 Oct;94(2-3):317-22.

14. Antihyperglycemic activity of the aqueous extract of Urtica dioica.

Bnouham M, Merhfour FZ, Ziyyat A, Mekhfi H, Aziz M, Legssyer A.

Fitoterapia. 2003 Dec;74(7-8):677-81.

15. Arbutus unedo induces endothelium-dependent relaxation of the isolated rat aorta.

Ziyyat A, Mekhfi H, Bnouham M, Tahri A, Legssyer A, Hoerter J, Fischmeister R.

Phytother Res. 2002 Sep;16(6):572-5.

16. Cardiovascular effects of Urtica dioica L. in isolated rat heart and aorta.

Legssyer A, Ziyyat A, Mekhfi H, Bnouham M, Tahri A, Serhrouchni M, Hoerter J, Fischmeister R.

Phytother Res. 2002 Sep;16(6):503-7.

17. Acute diuretic, natriuretic and hypotensive effects of a continuous perfusion of aqueous extract of Urtica dioica in the rat.

Tahri A, Yamani S, Legssyer A, Aziz M, Mekhfi H, Bnouham M, Ziyyat A.

J Ethnopharmacol. 2000 Nov;73(1-2):95-100.

18. Food deprivation modifies fatty acid partitioning and beta-oxidation capacity in rat liver.

Andriamampandry MD, Bnouham M, Michard D, Gutbier G, Le Maho Y, Leray C.

J Nutr. 1996 Aug;126(8):2020-7.

19. Body protein and lipid deficit in tumour-bearing rats in relation to age.

Oudart H, Heitz A, Bnouham M, Malan A, Le Maho Y.

Br J Cancer. 1993 Nov;68(5):885-9.

Publications

  1. pmc Body protein and lipid deficit in tumour-bearing rats in relation to age
    H Oudart
    , CNRS, Strasbourg, France
    Br J Cancer 68:885-9. 1993
  2. ncbi request reprint Artemisia herba-alba Asso relaxes the rat aorta through activation of NO/cGMP pathway and K(ATP) channels
    Mounia Skiker
    Laboratoire de Physiologie et Ethnopharmacologie, Departement de Biologie, Faculte des Sciences, Université Mohamed Premier
    J Smooth Muscle Res 46:165-74. 2010
  3. ncbi request reprint Anti-diarrhoeal activity of crude aqueous extract of Rubia tinctorum L. roots in rodents
    Ahmed Karim
    Laboratoire de Physiologie et Ethnopharmacologie, Macromoléculaire et Produits Naturels, Université Mohammed 1er, Faculte des Sciences
    J Smooth Muscle Res 46:119-23. 2010
  4. ncbi request reprint Antidiabetic medicinal plants as a source of alpha glucosidase inhibitors
    Wafaa Benalla
    Laboratoire de Physiologie et Ethnopharmacologie, Departement de Biologie, 60000 Oujda, Morocco
    Curr Diabetes Rev 6:247-54. 2010
  5. doi request reprint Antidiabetic effect of some medicinal plants of Oriental Morocco in neonatal non-insulin-dependent diabetes mellitus rats
    Mohamed Bnouham
    Laboratory of Physiology and Ethnopharmacology, UFR Physiology and Pharmacology, Department of Biology, Faculty of Sciences, University Mohamed Ist, Oujda, Morocco
    Hum Exp Toxicol 29:865-71. 2010
  6. doi request reprint Antihypertensive and endothelium-dependent vasodilator effects of aqueous extract of Cistus ladaniferus
    Mounia Belmokhtar
    Laboratoire de Physiologie et Ethnopharmacologie, Université Mohamed Premier, Faculte des Sciences, Oujda, Morocco
    Biochem Biophys Res Commun 389:145-9. 2009
  7. ncbi request reprint Parsley extract inhibits in vitro and ex vivo platelet aggregation and prolongs bleeding time in rats
    Dounia Gadi
    Université Mohamed I er, Faculte des Sciences, Laboratoire de Physiologie et Ethnopharmacologie, UFR Physiologie et Pharmacologie, BP717, Oujda, Morocco
    J Ethnopharmacol 125:170-4. 2009
  8. doi request reprint Arbutus unedo prevents cardiovascular and morphological alterations in L-NAME-induced hypertensive rats Part I: cardiovascular and renal hemodynamic effects of Arbutus unedo in L-NAME-induced hypertensive rats
    Saida Afkir
    UFR Physiologie et Pharmacologie, Laboratoire de Physiologie et Ethnopharmacologie, Departement de Biologie, Faculte des Sciences, Université Mohamed Premier, BP 717, Bd Mohamed VI, 60000 Oujda, Morocco
    J Ethnopharmacol 116:288-95. 2008
  9. ncbi request reprint Antihyperglycemic activity of Arbutus unedo, Ammoides pusilla and Thymelaea hirsuta
    M Bnouham
    Laboratory of Physiology and Ethnopharmacology, UFR Physiology and Pharmacology, Department of Biology Faculty of Sciences, University Mohamed Ist, Oujda, Morocco
    Pharmazie 62:630-2. 2007
  10. ncbi request reprint Relaxant effect of aqueous extract of Cistus ladaniferus on rodent intestinal contractions
    Mohammed Aziz
    Laboratoire de Physiologie Ethnopharmacologie, UFR Physiologie et Pharmacologie Département de Biologie, Université Mohamed Premier, Faculte des Sciences, BP 717, 60000 Oujda, Morocco
    Fitoterapia 77:425-8. 2006

Collaborators

  • Abdelkhaleq Legssyer
  • Hassane Mekhfi
  • Rodolphe Fischmeister
  • Saad Lahlou
  • Vincent Roumy
  • Souliman Amrani
  • F Atmani
  • Abderrahim Ziyyat
  • Mohammed Aziz
  • Mohamed Aziz
  • Ahmed Karim
  • Ali Berraaouan
  • Mounia Skiker
  • Wafaa Benalla
  • Mounia Belmokhtar
  • Dounia Gadi
  • Saida Afkir
  • Ahmed Melhaoui
  • Mohammed El Haouari
  • Sanae Abid
  • Saïd Bellahcen
  • A Tahri
  • Benyounes Haloui
  • Nour Elhouda Bouanani
  • Philippe Mateo
  • Françoise Fauvel Lafeve
  • Chantal Legrand
  • Johar Zoheir
  • Telesphore Benoit Nguelefack
  • Guy Cuisinaud
  • Naoual Tab
  • Mourad Bendahou
  • Abdelhafid Tahri
  • Jacqueline Hoerter
  • M Aziz
  • S Yamani
  • A Ziyyat
  • H Oudart
  • Y Le Maho
  • A Malan
  • A Heitz

Detail Information

Publications20

  1. pmc Body protein and lipid deficit in tumour-bearing rats in relation to age
    H Oudart
    , CNRS, Strasbourg, France
    Br J Cancer 68:885-9. 1993
    ..In conclusion, as previously shown in uncomplicated undernutrition, the anorexia induced by Yoshida sarcoma development is still associated with some protein accretion in young rats whereas cachexia develops in adults...
  2. ncbi request reprint Artemisia herba-alba Asso relaxes the rat aorta through activation of NO/cGMP pathway and K(ATP) channels
    Mounia Skiker
    Laboratoire de Physiologie et Ethnopharmacologie, Departement de Biologie, Faculte des Sciences, Université Mohamed Premier
    J Smooth Muscle Res 46:165-74. 2010
    ..Activation of ATP-dependent potassium channels partly contributes in the mediation of AHAE-induced endothelium-dependent relaxation...
  3. ncbi request reprint Anti-diarrhoeal activity of crude aqueous extract of Rubia tinctorum L. roots in rodents
    Ahmed Karim
    Laboratoire de Physiologie et Ethnopharmacologie, Macromoléculaire et Produits Naturels, Université Mohammed 1er, Faculte des Sciences
    J Smooth Muscle Res 46:119-23. 2010
    ..These data suggest that Rubia tinctorum showed antidiarrhoeal activity by inhibiting intestinal motility which was concordant with its use in traditional medicine...
  4. ncbi request reprint Antidiabetic medicinal plants as a source of alpha glucosidase inhibitors
    Wafaa Benalla
    Laboratoire de Physiologie et Ethnopharmacologie, Departement de Biologie, 60000 Oujda, Morocco
    Curr Diabetes Rev 6:247-54. 2010
    ....
  5. doi request reprint Antidiabetic effect of some medicinal plants of Oriental Morocco in neonatal non-insulin-dependent diabetes mellitus rats
    Mohamed Bnouham
    Laboratory of Physiology and Ethnopharmacology, UFR Physiology and Pharmacology, Department of Biology, Faculty of Sciences, University Mohamed Ist, Oujda, Morocco
    Hum Exp Toxicol 29:865-71. 2010
    ..In conclusion, it seems that these plants possess antidiabetic activity...
  6. doi request reprint Antihypertensive and endothelium-dependent vasodilator effects of aqueous extract of Cistus ladaniferus
    Mounia Belmokhtar
    Laboratoire de Physiologie et Ethnopharmacologie, Université Mohamed Premier, Faculte des Sciences, Oujda, Morocco
    Biochem Biophys Res Commun 389:145-9. 2009
    ..We conclude that C. ladaniferus possesses antihypertensive properties which are mainly due to an endothelium-dependent vasodilatory action...
  7. ncbi request reprint Parsley extract inhibits in vitro and ex vivo platelet aggregation and prolongs bleeding time in rats
    Dounia Gadi
    Université Mohamed I er, Faculte des Sciences, Laboratoire de Physiologie et Ethnopharmacologie, UFR Physiologie et Pharmacologie, BP717, Oujda, Morocco
    J Ethnopharmacol 125:170-4. 2009
    ....
  8. doi request reprint Arbutus unedo prevents cardiovascular and morphological alterations in L-NAME-induced hypertensive rats Part I: cardiovascular and renal hemodynamic effects of Arbutus unedo in L-NAME-induced hypertensive rats
    Saida Afkir
    UFR Physiologie et Pharmacologie, Laboratoire de Physiologie et Ethnopharmacologie, Departement de Biologie, Faculte des Sciences, Université Mohamed Premier, BP 717, Bd Mohamed VI, 60000 Oujda, Morocco
    J Ethnopharmacol 116:288-95. 2008
    ..These results show that chronic treatment with Arbutus extract regress the development of hypertension and ameliorate cardiovascular and renal functions in NO deficient hypertension...
  9. ncbi request reprint Antihyperglycemic activity of Arbutus unedo, Ammoides pusilla and Thymelaea hirsuta
    M Bnouham
    Laboratory of Physiology and Ethnopharmacology, UFR Physiology and Pharmacology, Department of Biology Faculty of Sciences, University Mohamed Ist, Oujda, Morocco
    Pharmazie 62:630-2. 2007
    ..Toxicity tests (high LD50 value) suggest no adverse effect of the use of these plants...
  10. ncbi request reprint Relaxant effect of aqueous extract of Cistus ladaniferus on rodent intestinal contractions
    Mohammed Aziz
    Laboratoire de Physiologie Ethnopharmacologie, UFR Physiologie et Pharmacologie Département de Biologie, Université Mohamed Premier, Faculte des Sciences, BP 717, 60000 Oujda, Morocco
    Fitoterapia 77:425-8. 2006
    ..This result suggests that the antispasmodic action of the extract is mediated through calcium channel blockade. The results confirm the traditional use of C. ladaniferus in treating intestinal ache...
  11. ncbi request reprint Inhibition of rat platelet aggregation by Urtica dioica leaves extracts
    Mohammed El Haouari
    Laboratoire de Physiologie et Ethnopharmacologie, UFR Physiologie et Pharmacologie, Departement de Biologie, Faculte des Sciences, Université Mohamed Premier, BP 717, 60000 Oujda, Morocco
    Phytother Res 20:568-72. 2006
    ..It is concluded that Urtica dioica has an antiplatelet action in which flavonoids are mainly implicated. These results support the traditional use of Urtica dioica in the treatment and/or prevention of cardiovascular disease...
  12. ncbi request reprint Acute diuretic, natriuretic and hypotensive effects of a continuous perfusion of aqueous extract of Urtica dioica in the rat
    A Tahri
    Laboratoire de Physiologie et Pharmacologie Cellulaire, Faculte des Sciences, Université Mohammed Premier, B P 524, 60000, Oujda, Morocco
    J Ethnopharmacol 73:95-100. 2000
    ..Moreover, diuretic and natriuretic effects were also observed, suggesting an action on the renal function. Finally, the plant extract seems to have a toxic effect at the higher dose...
  13. ncbi request reprint Cardiovascular effects of Urtica dioica L. in isolated rat heart and aorta
    Abdelkhaleq Legssyer
    Laboratoire de Physiologie et Pharmacologie Cellulaire, Departement de Biologie, Facultedes Sciences, Université Mohamed Premier, BP 524, 60000 Oujda, Maroc
    Phytother Res 16:503-7. 2002
    ..However, AEN also induces a strong bradycardia through non-cholinergic and non-adrenergic pathways which might compensate for its vascular effect and account for the hypotensive action of Urtica dioica L described in vivo...
  14. ncbi request reprint Arbutus unedo induces endothelium-dependent relaxation of the isolated rat aorta
    Abderrahim Ziyyat
    Laboratoire de Physiologie et Pharmacologie Cellulaire, Departement de Biologie, Faculte des Sciences, Université Mohamed Premier, BP 524, Route Sidi Maafa, 60000 Oujda, Maroc
    Phytother Res 16:572-5. 2002
    ....
  15. ncbi request reprint Antihyperglycemic activity of the aqueous extract of Urtica dioica
    Mohamed Bnouham
    Laboratoire de Physiologie et Pharmacologie Cellulaire, UFR de Physiologie et Pharmacologie, Departement de Biologie, Faculte des Sciences, Université Mohamed Ier, Oujda B P 524, Morocco
    Fitoterapia 74:677-81. 2003
    ..05). The results indicate that nettle has a significant antihyperglycemic effect in OGTT model. This effect may be caused in part by the reduction of intestinal glucose absorption. LD(50) is 3.5 g/kg (i.p.)...
  16. ncbi request reprint Platelet anti-aggregant property of some Moroccan medicinal plants
    Hassane Mekhfi
    Laboratoire de Physiologie et Pharmacologie Cellulaire, Departement de Biologie, Université Mohamed 1er, Faculte des Sciences, Bd Mohamed VI, BP 717, Oujda 60000, Morocco
    J Ethnopharmacol 94:317-22. 2004
    ..Phytochemical separation must be carried out to identify the active principles responsible for the anti-aggregant effect and elucidate their mechanisms of action...
  17. ncbi request reprint Tannins and catechin gallate mediate the vasorelaxant effect of Arbutus unedo on the rat isolated aorta
    Abdelkhaleq Legssyer
    Laboratoire de Physiologie et Pharmacologie Cellulaire, Departement de Biologie, Université Mohamed Premier, Faculte des Sciences, BP 524, 60000 Oujda, Morocco
    Phytother Res 18:889-94. 2004
    ..Analysis of Fr6 indicated that this fraction contained catechin gallate. In conclusion, the vasorelaxant activity of Arbutus is likely to be due to polyphenol compounds, primarily condensed tannins and catechin gallate...
  18. ncbi request reprint Effects of extracts and tannins from Arbutus unedo leaves on rat platelet aggregation
    Hassane Mekhfi
    Laboratoire de Physiologie et Pharmacologie Cellulaire, Faculte des Sciences, Departement de Biologie, UFR de Physiologie et Pharmacologie, Université Mohamed 1er, Boulevard Mohamed VI, BP 717, 60000 Oujda, Morocco
    Phytother Res 20:135-9. 2006
    ..4, n = 8) and may be the major chemical compounds responsible for this action. Our results support the traditional use of this plant in the preventive or therapeutic treatment of platelet aggregation linked to arterial hypertension...
  19. ncbi request reprint Antidiabetic oils
    Ali Berraaouan
    Laboratory of Physiology and Ethnopharmacology URAC 40, Department of Biology Faculty of Sciences, University Mohamed Ist, Boulevard Mohamed VI BP 717 60 000, Oujda, Morocco
    Curr Diabetes Rev 9:499-505. 2013
    ..It seems that many vegetable oils are really interesting and can be used in the improvement of human health, particularly, to prevent or to treat diabetes mellitus complications. ..
  20. ncbi request reprint Antidiabetic and antihypertensive effect of a polyphenol-rich fraction of Thymelaea hirsuta L. in a model of neonatal streptozotocin-diabetic and N(G) -nitro-l-arginine methyl ester-hypertensive rats
    Mohamed Bnouham
    Department of Biology, University Mohamed Ist, Oujda, Morocco
    J Diabetes 4:307-13. 2012
    ..The present study examined the effect of the polyphenol-rich fraction from Thymelaea hirsuta (PRF-Th) in a rat model of streptozotocin (STZ)-diabetes and nitric oxide (NO)-deficient hypertension...