Stephane Blanche

Summary

Country: France

Publications

  1. ncbi [Possible long-term effect of in utero antiretroviral exposure?]
    S Blanche
    Unité d Immunologie Hématologie Pédiatrique, Assistance Publique Hopitaux de Paris, Hopital Necker, 149, rue de Sevres, 75743 Paris Cedex 15, France
    Arch Pediatr 14:610-1. 2007
  2. ncbi Pharmacokinetics, safety and efficacy of darunavir/ritonavir in treatment-experienced children and adolescents
    Stephane Blanche
    Unité d Immunologie Hématologie Pédiatrique, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, 149 rue de Sevres, Paris Cedex 15, France
    AIDS 23:2005-13. 2009
  3. ncbi Mitochondrial dysfunction following perinatal exposure to nucleoside analogues
    Stephane Blanche
    Unité d Immunologie Hématologie Pédiatrique, Hopital Necker Enfants Malades, Assistance Subligne Hopitaux de Paris et EA 3620 Université Paris 5, 149 rue de Sevres, 75015 Paris, France
    AIDS 20:1685-90. 2006
  4. ncbi Poor recognition of HIV-1 Nef protein by CD8 T cells from HIV-1-infected children: impact of age
    Florence Buseyne
    Unite Postulante d Immunopathologie Virale, URA CNRS 1930, Institut Pasteur, Bat Lwoff, 28 rue du Dr Roux, 75015 Paris, France
    Virology 354:271-9. 2006
  5. ncbi [Chronic granulomatous disease: pathogenesis and therapy of associated fungal infections]
    ANNE DESJARDINS
    Service de Maladies Infectieuses et Tropicales, Hopital Necker Enfants Malades, Paris, France
    Med Sci (Paris) 28:963-9. 2012
  6. ncbi Prevalence and clinical impact of norovirus fecal shedding in children with inherited immune deficiencies
    Pierre Frange
    Unite d immunologie, Hématologie et Rhumatologie pédiatriques, AP HP, Hopital Necker Enfants Malades, 149 rue de Sevres, 75015 Paris, France
    J Infect Dis 206:1269-74. 2012
  7. ncbi Invasive mold infections in chronic granulomatous disease: a 25-year retrospective survey
    Sophie Blumental
    Immunology and Haematology Unit, Hopital Necker Enfants Malades, Paris, France
    Clin Infect Dis 53:e159-69. 2011
  8. ncbi Lopinavir/ritonavir-based antiretroviral therapy in human immunodeficiency virus type 1-infected naive children: rare protease inhibitor resistance mutations but high lamivudine/emtricitabine resistance at the time of virologic failure
    Pierre Frange
    Unite d immunologie, Hématologie et Rhumatologie pédiatriques, Assistance Publique Hopitaux de Paris, Hopital Necker, Paris, France
    Pediatr Infect Dis J 30:684-8. 2011
  9. ncbi A vaccinia-based elispot assay for detection of CD8+ T cells from HIV-1 infected children
    Florence Buseyne
    Unite Postulante d Immunopathologie Virale, URA CNRS 1930, Institut Pasteur, Bat Lwoff, 28 rue du Dr Roux, 75015 Paris, France
    J Immunol Methods 298:105-18. 2005
  10. ncbi In HIV type 1-infected children cytotoxic T lymphocyte responses are associated with greater reduction of viremia under antiretroviral therapy
    Florence Buseyne
    Unite Postulante d Immunopathologie Virale, URA CNRS 1930, Institut Pasteur, Bat Lwoff, 75015 Paris, France
    AIDS Res Hum Retroviruses 21:719-27. 2005

Detail Information

Publications40

  1. ncbi [Possible long-term effect of in utero antiretroviral exposure?]
    S Blanche
    Unité d Immunologie Hématologie Pédiatrique, Assistance Publique Hopitaux de Paris, Hopital Necker, 149, rue de Sevres, 75743 Paris Cedex 15, France
    Arch Pediatr 14:610-1. 2007
  2. ncbi Pharmacokinetics, safety and efficacy of darunavir/ritonavir in treatment-experienced children and adolescents
    Stephane Blanche
    Unité d Immunologie Hématologie Pédiatrique, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, 149 rue de Sevres, Paris Cedex 15, France
    AIDS 23:2005-13. 2009
    ..To assess pharmacokinetics, safety and efficacy of darunavir/ritonavir (DRV/r) and optimized background regimen in treatment-experienced patients (6-17 years)...
  3. ncbi Mitochondrial dysfunction following perinatal exposure to nucleoside analogues
    Stephane Blanche
    Unité d Immunologie Hématologie Pédiatrique, Hopital Necker Enfants Malades, Assistance Subligne Hopitaux de Paris et EA 3620 Université Paris 5, 149 rue de Sevres, 75015 Paris, France
    AIDS 20:1685-90. 2006
  4. ncbi Poor recognition of HIV-1 Nef protein by CD8 T cells from HIV-1-infected children: impact of age
    Florence Buseyne
    Unite Postulante d Immunopathologie Virale, URA CNRS 1930, Institut Pasteur, Bat Lwoff, 28 rue du Dr Roux, 75015 Paris, France
    Virology 354:271-9. 2006
    ..The poor Nef-specific CD8 T cell response in HIV-infected children contrasts with dominance of Nef-specific responses in infected adults...
  5. ncbi [Chronic granulomatous disease: pathogenesis and therapy of associated fungal infections]
    ANNE DESJARDINS
    Service de Maladies Infectieuses et Tropicales, Hopital Necker Enfants Malades, Paris, France
    Med Sci (Paris) 28:963-9. 2012
    ..Here we review the genetic basis, pathogenesis and clinical presentation associated with fungal infections in chronic granulomatous disease as well as the current prophylaxis and newly available therapies...
  6. ncbi Prevalence and clinical impact of norovirus fecal shedding in children with inherited immune deficiencies
    Pierre Frange
    Unite d immunologie, Hématologie et Rhumatologie pédiatriques, AP HP, Hopital Necker Enfants Malades, 149 rue de Sevres, 75015 Paris, France
    J Infect Dis 206:1269-74. 2012
    ..1% of fecal samples were still positive after a median of 9.5-months follow-up. Further large longitudinal studies are needed to evaluate the clinical consequences of norovirus shedding in patients with primary immunodeficiencies...
  7. ncbi Invasive mold infections in chronic granulomatous disease: a 25-year retrospective survey
    Sophie Blumental
    Immunology and Haematology Unit, Hopital Necker Enfants Malades, Paris, France
    Clin Infect Dis 53:e159-69. 2011
    ..This study offers a descriptive review of invasive mold infection (mIFI) in children with CGD over an extended period of time...
  8. ncbi Lopinavir/ritonavir-based antiretroviral therapy in human immunodeficiency virus type 1-infected naive children: rare protease inhibitor resistance mutations but high lamivudine/emtricitabine resistance at the time of virologic failure
    Pierre Frange
    Unite d immunologie, Hématologie et Rhumatologie pédiatriques, Assistance Publique Hopitaux de Paris, Hopital Necker, Paris, France
    Pediatr Infect Dis J 30:684-8. 2011
    ..Lopinavir/ritonavir (LPV/r) is now the protease inhibitor regimen of choice in the first-line antiretroviral therapy for children <6 years of age...
  9. ncbi A vaccinia-based elispot assay for detection of CD8+ T cells from HIV-1 infected children
    Florence Buseyne
    Unite Postulante d Immunopathologie Virale, URA CNRS 1930, Institut Pasteur, Bat Lwoff, 28 rue du Dr Roux, 75015 Paris, France
    J Immunol Methods 298:105-18. 2005
    ....
  10. ncbi In HIV type 1-infected children cytotoxic T lymphocyte responses are associated with greater reduction of viremia under antiretroviral therapy
    Florence Buseyne
    Unite Postulante d Immunopathologie Virale, URA CNRS 1930, Institut Pasteur, Bat Lwoff, 75015 Paris, France
    AIDS Res Hum Retroviruses 21:719-27. 2005
    ..This result adds further support to the hypothesis that cooperation between the antiviral immune response and antiviral drugs could be helpful for therapeutic management of HIV-infected patients...
  11. ncbi LTR real-time PCR for HIV-1 DNA quantitation in blood cells for early diagnosis in infants born to seropositive mothers treated in HAART area (ANRS CO 01)
    Véronique Avettand-Fenoel
    Assistance Publique Hopitaux de Paris, CHU Necker Enfants Malades, Service de Virologie, Paris, France
    J Med Virol 81:217-23. 2009
    ..The results were equivalent to those of HIV-RNA assay. HIV-DNA may be used even in masked primary infection in newborns whose mothers have received HAART...
  12. ncbi Morbidity and mortality from ataxia-telangiectasia are associated with ATM genotype
    Romain Micol
    CEREDIH, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, 75743 Paris Cedex 15, France
    J Allergy Clin Immunol 128:382-9.e1. 2011
    ..The course of the disease is characterized by neurologic manifestations, infections, and cancers...
  13. ncbi Therapeutic drug monitoring of voriconazole after intravenous administration in infants and children with primary immunodeficiency
    Magdalena Gerin
    Universite Paris Descartes, Assistance Publique Hopitaux de Paris, Paris, France
    Ther Drug Monit 33:464-6. 2011
    ..The aim of this work was to describe the probability of not achieving this target concentration in infants and children receiving intravenous voriconazole...
  14. ncbi Association of prenatal and postnatal exposure to lopinavir-ritonavir and adrenal dysfunction among uninfected infants of HIV-infected mothers
    Albane Simon
    Unité d Endocrinologie Pédiatrique, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France
    JAMA 306:70-8. 2011
    ..A warning about its tolerance in premature newborns was recently released, and transient elevation of 17-hydroxyprogesterone (17OHP) was noted in 2 newborns treated with lopinavir-ritonavir in France...
  15. ncbi Late postnatal HIV infection in children born to HIV-1-infected mothers in a high-income country
    Pierre Frange
    Unite d immunologie, Hématologie et Rhumatologie pédiatriques, Hopital Necker, Paris, France
    AIDS 24:1771-6. 2010
    ..To evaluate the risk of late postnatal HIV-1 infection in nonbreastfed children enrolled in the French ANRS Cohort CO01 (EPF)...
  16. ncbi CCR5 antagonists: a therapeutic option in HIV-1 perinatally infected children experiencing virologic failure?
    Pierre Frange
    Université Paris Descartes EA 3620, Sorbonne Paris Cité, Paris, France
    AIDS 26:1673-7. 2012
    ..HIV-1 coreceptor usage was determined in HAART-failing children followed in Necker Hospital (Paris, France) in order to estimate the proportion of these patients who may benefit from CCR5-antagonists therapy...
  17. ncbi Protective effect of IgM against colonization of the respiratory tract by nontypeable Haemophilus influenzae in patients with hypogammaglobulinemia
    Romain Micol
    CEREDIH network French National Reference Center for Primary Immunodeficiencies, Hopital Necker Enfants Malades, AP HP, Paris, France
    J Allergy Clin Immunol 129:770-7. 2012
    ..It is not known whether patients able to secrete IgM (eg, those with hyper-IgM [HIgM] syndrome) are as susceptible to these infections as patients who lack IgM production (eg, those with panhypogammaglobulinemia [PHG])...
  18. ncbi Performance of HIV-1 DNA or HIV-1 RNA tests for early diagnosis of perinatal HIV-1 infection during anti-retroviral prophylaxis
    Marianne Burgard
    Laboratoire de Virologie, Hopital Necker, AP HP, Paris, France
    J Pediatr 160:60-6.e1. 2012
    ..To compare performance of testing for human immunodeficiency virus (HIV)-1 DNA and HIV-1 RNA for diagnosis of HIV-1 infection in infants receiving preventive antiretroviral therapy...
  19. ncbi Primary T-cell immunodeficiency with immunodysregulation caused by autosomal recessive LCK deficiency
    Fabian Hauck
    Inserm 768, Laboratoire du Développement Normal et Pathologique du Système Immunitaire, Hopital Necker Enfants Malades, Paris, France
    J Allergy Clin Immunol 130:1144-1152.e11. 2012
    ..The T lymphocyte-specific protein tyrosine kinase (Lck) is a key component of the TCR signaling machinery. On the basis of its function, we considered LCK a candidate gene in patients with combined immunodeficiency...
  20. ncbi Major histocompatibility complex class II expression deficiency caused by a RFXANK founder mutation: a survey of 35 patients
    Monia Ouederni
    Pediatric Hematology Immunology Unit, Assistance Publique Hopitaux de Paris, Necker Hospital, France
    Blood 118:5108-18. 2011
    ..RFXANK deficiency is a severe, often fatal CID for which HSCT is the only curative treatment. However, some patients may survive for relatively long periods if multiple prophylactic measures are implemented...
  21. ncbi Functional consequences of perforin gene mutations in 22 patients with familial haemophagocytic lymphohistiocytosis
    Jerome Feldmann
    Unité de Recherche sur le Développement Normal et Pathologique du Système Immunitaire, INSERM U429, Hopital Necker Enfants Malades, 149 rue de Sevres, 75743 Paris Cedex 15, France
    Br J Haematol 117:965-72. 2002
    ..Altogether, these data enabled a better characterization of perforin deficiency and its consequences, and defined reliable diagnostic tools...
  22. ncbi Immunotherapy of familial hemophagocytic lymphohistiocytosis with antithymocyte globulins: a single-center retrospective report of 38 patients
    Nizar Mahlaoui
    Unité d Immunologie et Hématologie Pédiatrique, Hopital Necker Enfants Malades, 149 rue de Sevres, 75015 Paris, France
    Pediatrics 120:e622-8. 2007
    ....
  23. ncbi Epidemiology and outcome of invasive fungal diseases in patients with chronic granulomatous disease: a multicenter study in France
    Julien Beauté
    Centre de Référence Déficits Immunitaires Héréditaires, Hopital Necker Enfants Malades, AP HP, Paris, France
    Pediatr Infect Dis J 30:57-62. 2011
    ..This study is aimed at assessing the incidence, prevalence, and outcome of IFDs among CGD patients followed in France...
  24. ncbi Long-term outcome after hematopoietic stem cell transplantation of a single-center cohort of 90 patients with severe combined immunodeficiency
    Benedicte Neven
    Unité d Immuno Hématologie et Rhumatologie Pédiatrique, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France
    Blood 113:4114-24. 2009
    ..In most cases, HSCT enables long-term survival with infrequent sequelae. However, the occurrence of relatively late-onset complications is a concern that requires specific means of prevention and justifies careful patient follow-up...
  25. ncbi Predictive factors of virologic success in HIV-1-infected children treated with lopinavir/ritonavir
    Constance Delaugerre
    Service de Virologie EA 3620, Hopital Necker Enfants Malades, Paris, France
    J Acquir Immune Defic Syndr 37:1269-75. 2004
    ..In pretreated children, LPV plasma levels should be optimized in an attempt to achieve sufficient drug concentrations to overcome the resistance level...
  26. ncbi Autosomal dominant STAT3 deficiency and hyper-IgE syndrome: molecular, cellular, and clinical features from a French national survey
    Marie Olivia Chandesris
    Hematology Department, Necker Enfants Malades Hospital, Assistance Publique Hopitaux de Paris, Paris, France
    Medicine (Baltimore) 91:e1-19. 2012
    ..Overall, the prognosis of STAT3 deficiency may be considered good, provided that multiple prophylactic measures, including IgG infusions, are implemented...
  27. ncbi Influence of development, HIV infection, and antiretroviral therapies on the gene expression profiles of ABC transporters in human lymphocytes
    Carole Giraud
    Centre de Recherche Clinique Paris Descartes, Groupe Hospitalier Cochin Saint Vincent De Paul, Assistance Publique Hopitaux de Paris, Site Hôpital Tarnier, 75006 Paris, France
    J Clin Pharmacol 50:226-30. 2010
    ..Neither HIV infection nor antiretroviral therapies modulated the gene expression profiles of ABC transporters. In conclusion, drugs that are substrates of BCRP and MRP4, like zidovudine, may have an altered efficacy in newborns...
  28. ncbi Clinical similarities and differences of patients with X-linked lymphoproliferative syndrome type 1 (XLP-1/SAP deficiency) versus type 2 (XLP-2/XIAP deficiency)
    Jana Pachlopnik Schmid
    INSERM Unité 768, Laboratoire du Développement Normal et Pathologique du Système Immunitaire, Hopital Necker Enfants Malades, Paris, France
    Blood 117:1522-9. 2011
    ..This first phenotypic comparison of XLP subtypes should help to improve the diagnosis and the care of patients with XLP conditions...
  29. ncbi Cutaneous hematologic disorders in children
    Olivia Boccara
    Department of Pathology, Hopital Necker Enfants Malades, AP HP, Universite Rene Descartes, Paris V, France
    Pediatr Blood Cancer 58:226-32. 2012
    ..To determine and list the clinical and pathological features of cutaneous hematologic diseases in childhood...
  30. ncbi Allogeneic bone marrow transplantation in mevalonic aciduria
    Benedicte Neven
    Unité d Immuno Hématologie et Rhumatologie Pédiatrique, Assistance Publique Hopitaux de Paris, Paris, France
    N Engl J Med 356:2700-3. 2007
    ..We observed sustained remission of febrile attacks and inflammation during a 15-month follow-up period...
  31. ncbi Primary cutaneous Epstein-Barr virus-related lymphoproliferative disorders in 4 immunosuppressed children
    Nadège Wallet-Faber
    Department of Pathology, Groupe Hospitalier Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Paris, France
    J Am Acad Dermatol 58:74-80. 2008
    ..The two T-cell types were also Epstein-Barr virus positive, which is extremely rare. Three of the patients developed extracutaneous disease with poor outcome, resulting in death...
  32. ncbi Adenoviral infection presenting as an isolated central nervous system disease without detectable viremia in two children after stem cell transplantation
    Pierre Frange
    Unite d immunologie, Hématologie et Rhumatologie pédiatriques, Hopital Necker Enfants Malades, 149 rue de Sevres, 75015 Paris, France
    J Clin Microbiol 49:2361-4. 2011
    ....
  33. ncbi Frequencies of ex vivo-activated human immunodeficiency virus type 1-specific gamma-interferon-producing CD8+ T cells in infected children correlate positively with plasma viral load
    Florence Buseyne
    Laboratoire d Immunopathologie Virale, Département de Médecine Moléculaire, URA CNRS 1930, Institut Pasteur, 28 rue du Dr Roux, 75015 Paris, France
    J Virol 76:12414-22. 2002
    ..In conclusion, our results show that the ex vivo-activated IFN-gamma-producing HIV-specific CD8+ T-cell subset is dependent upon continuous antigenic stimulation...
  34. ncbi Progressive neurologic dysfunctions 20 years after allogeneic bone marrow transplantation for Chediak-Higashi syndrome
    Marc Tardieu
    Service de Neurologie, Département de Pédiatrie et Laboratoire de Neuropathologie, Hopital Bicetre, Assistance Publique Hopitaux de Paris, Paris, France
    Blood 106:40-2. 2005
    ..We also reviewed the very long-term outcome of the other 11 patients with Chediak-Higashi syndrome who had received bone marrow transplants at our center since 1981. All displayed neurologic deficits or low cognitive abilities...
  35. ncbi Children's views on their involvement in clinical research
    Helene Chappuy
    Département d Urgences Pédiatriques, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris et Laboratoire d Ethique Médicale Université René Descartes Paris, France
    Pediatr Blood Cancer 50:1043-6. 2008
    ..To examine the level of children's understanding of informed consent in clinical trials and factors that may influence these processes...
  36. ncbi A survey of 90 patients with autoimmune lymphoproliferative syndrome related to TNFRSF6 mutation
    Benedicte Neven
    Inserm U768, Hopital Necker Enfants Malades, Paris, France
    Blood 118:4798-807. 2011
    ..We also noted a significantly greater occurrence of disease-related symptoms in male than in female patients...
  37. ncbi Monitoring cytomegalovirus infection in adult and pediatric bone marrow transplant recipients by a real-time PCR assay performed with blood plasma
    Marianne Leruez-Ville
    Laboratoire de Virologie, CHU Necker Enfants Malades, 75015 Paris, France
    J Clin Microbiol 41:2040-6. 2003
    ....
  38. ncbi Kaposi's sarcoma in a child with Wiskott-Aldrich syndrome
    Capucine Picard
    Unité d Immunologie et d Hématologie Pédiatriques AP HP, Hopital Necker Enfants Malades, 149 rue de Sevres, 75015, Paris, EU, France
    Eur J Pediatr 165:453-7. 2006
    ..Kaposi's sarcoma (KS) is rare in childhood. It may be favored by acquired immune deficiencies, but the predisposing factors to KS in other children are unclear...
  39. ncbi Thromboxane synthase mutations in an increased bone density disorder (Ghosal syndrome)
    David Genevieve
    Département de génétique, Unité INSERM U781, Universite Paris Descartes, Assistance Publique Hopitaux de Paris AP HP, Hopital Necker Enfants Malades, 149, rue de Sevres, 75015 Paris, France
    Nat Genet 40:284-6. 2008
    ..We also found that TXAS and TXA(2) modulated expression of TNFSF11 and TNFRSF11B (encoding RANKL and osteoprotegerin (OPG), respectively) in primary cultured osteoblasts...