Stephane Blanche

Summary

Country: France

Publications

  1. ncbi request reprint Mitochondrial dysfunction following perinatal exposure to nucleoside analogues
    Stephane Blanche
    Unité d Immunologie Hématologie Pédiatrique, Hopital Necker Enfants Malades, Assistance Subligne Hopitaux de Paris et EA 3620 Université Paris 5, 149 rue de Sevres, 75015 Paris, France
    AIDS 20:1685-90. 2006
  2. ncbi request reprint [Possible long-term effect of in utero antiretroviral exposure?]
    S Blanche
    Unité d Immunologie Hématologie Pédiatrique, Assistance Publique Hopitaux de Paris, Hopital Necker, 149, rue de Sevres, 75743 Paris Cedex 15, France
    Arch Pediatr 14:610-1. 2007
  3. doi request reprint Pharmacokinetics, safety and efficacy of darunavir/ritonavir in treatment-experienced children and adolescents
    Stephane Blanche
    Unité d Immunologie Hématologie Pédiatrique, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, 149 rue de Sevres, Paris Cedex 15, France
    AIDS 23:2005-13. 2009
  4. pmc Temporal and spatial compartmentalization of drug-resistant cytomegalovirus (CMV) in a child with CMV meningoencephalitis: implications for sampling in molecular diagnosis
    Pierre Frange
    Unite d immunologie, Hématologie et Rhumatologie Pédiatrique, Assistance Publique Hopitaux de Paris AP HP, Hopital Necker Enfants Malades, Paris, France
    J Clin Microbiol 51:4266-9. 2013
  5. ncbi request reprint Cutaneous EBV-related lymphoproliferative disorder in a 15-year-old boy with AIDS: an unusual clinical presentation
    Laurence Fardet
    Department of Pathology, Hopital Necker Enfants Malades, 149 rue de Sevres, 75015 Paris, France
    J Pediatr Hematol Oncol 24:666-9. 2002
  6. ncbi request reprint Change to a once-daily combination including boosted atazanavir in HIV-1-infected children
    Eugenia Macassa
    Unité d Immunologie Hématologie Pédiatrique, Paris, France
    Pediatr Infect Dis J 25:809-14. 2006
  7. ncbi request reprint Poor recognition of HIV-1 Nef protein by CD8 T cells from HIV-1-infected children: impact of age
    Florence Buseyne
    Unite Postulante d Immunopathologie Virale, URA CNRS 1930, Institut Pasteur, Bat Lwoff, 28 rue du Dr Roux, 75015 Paris, France
    Virology 354:271-9. 2006
  8. doi request reprint [Chronic granulomatous disease: pathogenesis and therapy of associated fungal infections]
    ANNE DESJARDINS
    Service de Maladies Infectieuses et Tropicales, Hopital Necker Enfants Malades, Paris, France
    Med Sci (Paris) 28:963-9. 2012
  9. ncbi request reprint Prevalence and clinical impact of norovirus fecal shedding in children with inherited immune deficiencies
    Pierre Frange
    Unite d immunologie, Hématologie et Rhumatologie pédiatriques, AP HP, Hopital Necker Enfants Malades, 149 rue de Sevres, 75015 Paris, France
    J Infect Dis 206:1269-74. 2012
  10. doi request reprint Invasive mold infections in chronic granulomatous disease: a 25-year retrospective survey
    Sophie Blumental
    Immunology and Haematology Unit, Hopital Necker Enfants Malades, Paris, France
    Clin Infect Dis 53:e159-69. 2011

Detail Information

Publications62

  1. ncbi request reprint Mitochondrial dysfunction following perinatal exposure to nucleoside analogues
    Stephane Blanche
    Unité d Immunologie Hématologie Pédiatrique, Hopital Necker Enfants Malades, Assistance Subligne Hopitaux de Paris et EA 3620 Université Paris 5, 149 rue de Sevres, 75015 Paris, France
    AIDS 20:1685-90. 2006
  2. ncbi request reprint [Possible long-term effect of in utero antiretroviral exposure?]
    S Blanche
    Unité d Immunologie Hématologie Pédiatrique, Assistance Publique Hopitaux de Paris, Hopital Necker, 149, rue de Sevres, 75743 Paris Cedex 15, France
    Arch Pediatr 14:610-1. 2007
  3. doi request reprint Pharmacokinetics, safety and efficacy of darunavir/ritonavir in treatment-experienced children and adolescents
    Stephane Blanche
    Unité d Immunologie Hématologie Pédiatrique, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, 149 rue de Sevres, Paris Cedex 15, France
    AIDS 23:2005-13. 2009
    ..To assess pharmacokinetics, safety and efficacy of darunavir/ritonavir (DRV/r) and optimized background regimen in treatment-experienced patients (6-17 years)...
  4. pmc Temporal and spatial compartmentalization of drug-resistant cytomegalovirus (CMV) in a child with CMV meningoencephalitis: implications for sampling in molecular diagnosis
    Pierre Frange
    Unite d immunologie, Hématologie et Rhumatologie Pédiatrique, Assistance Publique Hopitaux de Paris AP HP, Hopital Necker Enfants Malades, Paris, France
    J Clin Microbiol 51:4266-9. 2013
    ..However, wild-type cytomegalovirus was evidenced in blood when the meningoencephalitis was diagnosed. Treatment of meningoencephalitis should be adapted to all previously identified resistance mutations in any compartment. ..
  5. ncbi request reprint Cutaneous EBV-related lymphoproliferative disorder in a 15-year-old boy with AIDS: an unusual clinical presentation
    Laurence Fardet
    Department of Pathology, Hopital Necker Enfants Malades, 149 rue de Sevres, 75015 Paris, France
    J Pediatr Hematol Oncol 24:666-9. 2002
    ....
  6. ncbi request reprint Change to a once-daily combination including boosted atazanavir in HIV-1-infected children
    Eugenia Macassa
    Unité d Immunologie Hématologie Pédiatrique, Paris, France
    Pediatr Infect Dis J 25:809-14. 2006
    ..Pediatric experience with atazanavir combined with antiretroviral drugs administered once daily is very limited...
  7. ncbi request reprint Poor recognition of HIV-1 Nef protein by CD8 T cells from HIV-1-infected children: impact of age
    Florence Buseyne
    Unite Postulante d Immunopathologie Virale, URA CNRS 1930, Institut Pasteur, Bat Lwoff, 28 rue du Dr Roux, 75015 Paris, France
    Virology 354:271-9. 2006
    ..The poor Nef-specific CD8 T cell response in HIV-infected children contrasts with dominance of Nef-specific responses in infected adults...
  8. doi request reprint [Chronic granulomatous disease: pathogenesis and therapy of associated fungal infections]
    ANNE DESJARDINS
    Service de Maladies Infectieuses et Tropicales, Hopital Necker Enfants Malades, Paris, France
    Med Sci (Paris) 28:963-9. 2012
    ..Here we review the genetic basis, pathogenesis and clinical presentation associated with fungal infections in chronic granulomatous disease as well as the current prophylaxis and newly available therapies...
  9. ncbi request reprint Prevalence and clinical impact of norovirus fecal shedding in children with inherited immune deficiencies
    Pierre Frange
    Unite d immunologie, Hématologie et Rhumatologie pédiatriques, AP HP, Hopital Necker Enfants Malades, 149 rue de Sevres, 75015 Paris, France
    J Infect Dis 206:1269-74. 2012
    ..1% of fecal samples were still positive after a median of 9.5-months follow-up. Further large longitudinal studies are needed to evaluate the clinical consequences of norovirus shedding in patients with primary immunodeficiencies...
  10. doi request reprint Invasive mold infections in chronic granulomatous disease: a 25-year retrospective survey
    Sophie Blumental
    Immunology and Haematology Unit, Hopital Necker Enfants Malades, Paris, France
    Clin Infect Dis 53:e159-69. 2011
    ..This study offers a descriptive review of invasive mold infection (mIFI) in children with CGD over an extended period of time...
  11. doi request reprint Lopinavir/ritonavir-based antiretroviral therapy in human immunodeficiency virus type 1-infected naive children: rare protease inhibitor resistance mutations but high lamivudine/emtricitabine resistance at the time of virologic failure
    Pierre Frange
    Unite d immunologie, Hématologie et Rhumatologie pédiatriques, Assistance Publique Hopitaux de Paris, Hopital Necker, Paris, France
    Pediatr Infect Dis J 30:684-8. 2011
    ..Lopinavir/ritonavir (LPV/r) is now the protease inhibitor regimen of choice in the first-line antiretroviral therapy for children <6 years of age...
  12. ncbi request reprint A vaccinia-based elispot assay for detection of CD8+ T cells from HIV-1 infected children
    Florence Buseyne
    Unite Postulante d Immunopathologie Virale, URA CNRS 1930, Institut Pasteur, Bat Lwoff, 28 rue du Dr Roux, 75015 Paris, France
    J Immunol Methods 298:105-18. 2005
    ....
  13. ncbi request reprint In HIV type 1-infected children cytotoxic T lymphocyte responses are associated with greater reduction of viremia under antiretroviral therapy
    Florence Buseyne
    Unite Postulante d Immunopathologie Virale, URA CNRS 1930, Institut Pasteur, Bat Lwoff, 75015 Paris, France
    AIDS Res Hum Retroviruses 21:719-27. 2005
    ..This result adds further support to the hypothesis that cooperation between the antiviral immune response and antiviral drugs could be helpful for therapeutic management of HIV-infected patients...
  14. doi request reprint LTR real-time PCR for HIV-1 DNA quantitation in blood cells for early diagnosis in infants born to seropositive mothers treated in HAART area (ANRS CO 01)
    Véronique Avettand-Fenoel
    Assistance Publique Hopitaux de Paris, CHU Necker Enfants Malades, Service de Virologie, Paris, France
    J Med Virol 81:217-23. 2009
    ..The results were equivalent to those of HIV-RNA assay. HIV-DNA may be used even in masked primary infection in newborns whose mothers have received HAART...
  15. doi request reprint High exposure to zidovudine during the first 2 weeks of life and concentration-toxicity relationships
    Deborah Hirt
    AP HP, Unite de recherche clinique, Hôpital Tarnier, Paris, France CIC 0901 Inserm, Cochin Necker, Paris, France AP HP, Service de Pharmacologie Clinique, Hopital Cochin, Universite Paris Descartes, Sorbonne Paris Cité, Paris, France INSERM CESP U1018 Equipe VIH et IST, Le Kremlin Bicetre, France University of Paris Sud, Le Kremlin Bicetre, France AP HP, Service d Epidémiologie et Santé Publique, Hopital Bicetre, Le Kremlin Bicetre, France AP HP, Service de Neonatologie, hôpital Cochin Port Royal, Paris, France Université Paris Descartes EA 3620, Sorbonne Paris Cité, Paris, France Laboratoire d Ethique Médicale, Universite Paris Descartes, Paris, France Service d Urgences Pédiatriques, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France and AP HP, Unite d immunologie, Hématologie et Rhumatologie pédiatriques
    J Acquir Immune Defic Syndr 63:555-62. 2013
    ....
  16. ncbi request reprint Functional consequences of perforin gene mutations in 22 patients with familial haemophagocytic lymphohistiocytosis
    Jerome Feldmann
    Unité de Recherche sur le Développement Normal et Pathologique du Système Immunitaire, INSERM U429, Hopital Necker Enfants Malades, 149 rue de Sevres, 75743 Paris Cedex 15, France
    Br J Haematol 117:965-72. 2002
    ..Altogether, these data enabled a better characterization of perforin deficiency and its consequences, and defined reliable diagnostic tools...
  17. doi request reprint Morbidity and mortality from ataxia-telangiectasia are associated with ATM genotype
    Romain Micol
    CEREDIH, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, 75743 Paris Cedex 15, France
    J Allergy Clin Immunol 128:382-9.e1. 2011
    ..The course of the disease is characterized by neurologic manifestations, infections, and cancers...
  18. doi request reprint Therapeutic drug monitoring of voriconazole after intravenous administration in infants and children with primary immunodeficiency
    Magdalena Gerin
    Universite Paris Descartes, Assistance Publique Hopitaux de Paris, Paris, France
    Ther Drug Monit 33:464-6. 2011
    ..The aim of this work was to describe the probability of not achieving this target concentration in infants and children receiving intravenous voriconazole...
  19. pmc Autosomal dominant STAT3 deficiency and hyper-IgE syndrome: molecular, cellular, and clinical features from a French national survey
    Marie Olivia Chandesris
    Hematology Department, Necker Enfants Malades Hospital, Assistance Publique Hopitaux de Paris, Paris, France
    Medicine (Baltimore) 91:e1-19. 2012
    ..Overall, the prognosis of STAT3 deficiency may be considered good, provided that multiple prophylactic measures, including IgG infusions, are implemented...
  20. ncbi request reprint Characteristics of HIV-infected children recently diagnosed in Paris, France
    Eugenia Macassa
    Unité d Immunologie Hématologie Pédiatriques, Hopital Necker Enfants Malades, 149 rue de Sevres, 75015, Paris, France
    Eur J Pediatr 165:684-7. 2006
    ..HIV-1 infection should be taken into consideration in children born in countries with a high prevalence of HIV, even if they have been living in France for several years and present no symptoms...
  21. ncbi request reprint Abacavir pharmacokinetics in human immunodeficiency virus-infected children ranging in age from 1 month to 16 years: a population analysis
    Vincent Jullien
    Pharmacologie Clinique, Universite Rene Descartes, Groupe Hospitalier Cochin Saint Vincent De Paul, Assistance Publique Hopitaux de Paris, 82 avenue Denfert Rochereau, 75674 Paris Cedex 14, France
    J Clin Pharmacol 45:257-64. 2005
    ..5 +/- 2.5 mg x h/L, which is slightly greater than the mean AUC value reported in adults. This study confirms the relevance of the current weight-based abacavir dosage regimen in pediatric patients...
  22. doi request reprint Association of prenatal and postnatal exposure to lopinavir-ritonavir and adrenal dysfunction among uninfected infants of HIV-infected mothers
    Albane Simon
    Unité d Endocrinologie Pédiatrique, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France
    JAMA 306:70-8. 2011
    ..A warning about its tolerance in premature newborns was recently released, and transient elevation of 17-hydroxyprogesterone (17OHP) was noted in 2 newborns treated with lopinavir-ritonavir in France...
  23. doi request reprint Late postnatal HIV infection in children born to HIV-1-infected mothers in a high-income country
    Pierre Frange
    Unite d immunologie, Hématologie et Rhumatologie pédiatriques, Hopital Necker, Paris, France
    AIDS 24:1771-6. 2010
    ..To evaluate the risk of late postnatal HIV-1 infection in nonbreastfed children enrolled in the French ANRS Cohort CO01 (EPF)...
  24. doi request reprint CCR5 antagonists: a therapeutic option in HIV-1 perinatally infected children experiencing virologic failure?
    Pierre Frange
    Université Paris Descartes EA 3620, Sorbonne Paris Cité, Paris, France
    AIDS 26:1673-7. 2012
    ..HIV-1 coreceptor usage was determined in HAART-failing children followed in Necker Hospital (Paris, France) in order to estimate the proportion of these patients who may benefit from CCR5-antagonists therapy...
  25. doi request reprint Primary T-cell immunodeficiency with immunodysregulation caused by autosomal recessive LCK deficiency
    Fabian Hauck
    Inserm 768, Laboratoire du Développement Normal et Pathologique du Système Immunitaire, Hopital Necker Enfants Malades, Paris, France
    J Allergy Clin Immunol 130:1144-1152.e11. 2012
    ..The T lymphocyte-specific protein tyrosine kinase (Lck) is a key component of the TCR signaling machinery. On the basis of its function, we considered LCK a candidate gene in patients with combined immunodeficiency...
  26. ncbi request reprint Predictive factors of virologic success in HIV-1-infected children treated with lopinavir/ritonavir
    Constance Delaugerre
    Service de Virologie EA 3620, Hopital Necker Enfants Malades, Paris, France
    J Acquir Immune Defic Syndr 37:1269-75. 2004
    ..In pretreated children, LPV plasma levels should be optimized in an attempt to achieve sufficient drug concentrations to overcome the resistance level...
  27. pmc Evaluation of nevirapine dosing recommendations in HIV-infected children
    Frantz Foissac
    EA 3620 Université Paris Descartes Sorbonne Paris Cité, Unité de RechercheClinique, Hôpital Tarnier, 89 rue d Assas, Paris, France
    Br J Clin Pharmacol 76:137-44. 2013
    ..The aims of this study were to investigate the population pharmacokinetics of NVP in children, establish factors that influence NVP pharmacokinetics and evaluate the current dosing recommendations...
  28. doi request reprint Protective effect of IgM against colonization of the respiratory tract by nontypeable Haemophilus influenzae in patients with hypogammaglobulinemia
    Romain Micol
    CEREDIH network French National Reference Center for Primary Immunodeficiencies, Hopital Necker Enfants Malades, AP HP, Paris, France
    J Allergy Clin Immunol 129:770-7. 2012
    ..It is not known whether patients able to secrete IgM (eg, those with hyper-IgM [HIgM] syndrome) are as susceptible to these infections as patients who lack IgM production (eg, those with panhypogammaglobulinemia [PHG])...
  29. doi request reprint Performance of HIV-1 DNA or HIV-1 RNA tests for early diagnosis of perinatal HIV-1 infection during anti-retroviral prophylaxis
    Marianne Burgard
    Laboratoire de Virologie, Hopital Necker, AP HP, Paris, France
    J Pediatr 160:60-6.e1. 2012
    ..To compare performance of testing for human immunodeficiency virus (HIV)-1 DNA and HIV-1 RNA for diagnosis of HIV-1 infection in infants receiving preventive antiretroviral therapy...
  30. ncbi request reprint Vitamin D deficiency and insufficiency in HIV-infected children and young adults
    Candice Meyzer
    From the Unité de Recherche Clinique Paris Centre, Hopital Necker Enfants Malades, Assistance Publique Hôpitaux de Paris CIC P0901 Mère Enfant, INSERM, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Université Paris Descartes EA3620, Universite Paris Descartes, Sorbonne Paris Cité Unité d Immunologie et Hématologie Pédiatriques Urgences Pédiatriques, Hopital Necker Enfants Malades, Assistance Publique Hôpitaux de Paris Laboratoire d Ethique Médicale, Universite Paris Descartes, Paris Centre d Examens de Santé de la Caisse Primaire d Assurance Maladie de la Seine Saint Denis, Bobigny Service d Explorations Fonctionnelles, Hopital Necker Enfants Malades, Assistance Publique Hôpitaux de Paris INSERM U845, équipe Homéostasie du Phosphate, Université Paris Descartes Pharmacologie, Groupe Hospitalier Broca Cochin Hôtel Dieu and Service de Physiologie et Explorations Fonctionnelles, Hopital Europeen Georges Pompidou, Assistance Publique Hopitaux de Paris, Paris, France J M T and M C contributed equally to the study
    Pediatr Infect Dis J 32:1240-4. 2013
    ..Vitamin D insufficiency and HIV infection are both risk factors for chronic disorders, so it is important to consider vitamin D status in HIV-infected patients...
  31. ncbi request reprint Evaluation of a peer support group therapy for HIV-infected adolescents
    Isabelle Funck-Brentano
    Unité d Immunologie Hématologie Pédiatrique, Hopital Necker Enfants Malades, 149 rue de Sevres, 75743 Paris Cedex 15, France
    AIDS 19:1501-8. 2005
    ..To assess the effects of a peer support group therapy on HIV-infected adolescents...
  32. doi request reprint Major histocompatibility complex class II expression deficiency caused by a RFXANK founder mutation: a survey of 35 patients
    Monia Ouederni
    Pediatric Hematology Immunology Unit, Assistance Publique Hopitaux de Paris, Necker Hospital, France
    Blood 118:5108-18. 2011
    ..RFXANK deficiency is a severe, often fatal CID for which HSCT is the only curative treatment. However, some patients may survive for relatively long periods if multiple prophylactic measures are implemented...
  33. doi request reprint Epidemiology and outcome of invasive fungal diseases in patients with chronic granulomatous disease: a multicenter study in France
    Julien Beauté
    Centre de Référence Déficits Immunitaires Héréditaires, Hopital Necker Enfants Malades, AP HP, Paris, France
    Pediatr Infect Dis J 30:57-62. 2011
    ..This study is aimed at assessing the incidence, prevalence, and outcome of IFDs among CGD patients followed in France...
  34. doi request reprint Long-term outcome after hematopoietic stem cell transplantation of a single-center cohort of 90 patients with severe combined immunodeficiency
    Benedicte Neven
    Unité d Immuno Hématologie et Rhumatologie Pédiatrique, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France
    Blood 113:4114-24. 2009
    ..In most cases, HSCT enables long-term survival with infrequent sequelae. However, the occurrence of relatively late-onset complications is a concern that requires specific means of prevention and justifies careful patient follow-up...
  35. ncbi request reprint Immunotherapy of familial hemophagocytic lymphohistiocytosis with antithymocyte globulins: a single-center retrospective report of 38 patients
    Nizar Mahlaoui
    Unité d Immunologie et Hématologie Pédiatrique, Hopital Necker Enfants Malades, 149 rue de Sevres, 75015 Paris, France
    Pediatrics 120:e622-8. 2007
    ....
  36. pmc Association between prenatal exposure to antiretroviral therapy and birth defects: an analysis of the French perinatal cohort study (ANRS CO1/CO11)
    Jeanne Sibiude
    Hopital Louis Mourier, Assistance Publique Hopitaux de Paris, Colombes, France Centre de Recherche en Épidémiologie et Santé des Populations, Inserm U1018, Le Kremlin Bicetre, France
    PLoS Med 11:e1001635. 2014
    ..We estimated the prevalence of birth defects in children born to HIV-infected women receiving ART during pregnancy, and assessed the independent association of birth defects with each antiretroviral (ARV) drug used...
  37. ncbi request reprint Long-term survival and transplantation of haemopoietic stem cells for immunodeficiencies: report of the European experience 1968-99
    Corinne Antoine
    Service de Biostatistique et Service d Immunologie et d Hématologie Pédiatrique, Hopital Necker Enfants Malades, Paris, France
    Lancet 361:553-60. 2003
    ..This European report focuses on the long-term results of such procedures done between 1968 and December, 1999, for primary immunodeficiencies...
  38. ncbi request reprint Propionibacterium acnes chest infections in patients with chronic granulomatous disease: case reports
    Franck Bourdeaut
    Unité d Immunologie et Hématologie Pédiatrique, Hopital Necker Enfants Malades, Paris, France
    Clin Infect Dis 34:853-4. 2002
    ..Propionibacterium acnes, a saprophyte of the skin, is generally not involved in infections other than acne. Two cases of P. acnes extracutaneous infections in teenagers with CGD are reported...
  39. ncbi request reprint Osteopetrosis, lymphedema, anhidrotic ectodermal dysplasia, and immunodeficiency in a boy and incontinentia pigmenti in his mother
    Sophie Dupuis-Girod
    Unité d Immunologie et d Hé matologie pédiatriques, Hopital Necker Enfants Malades, Paris, France
    Pediatrics 109:e97. 2002
    ..In contrast, loss-of-function mutations and hypomorphic mutations may cause IP in females...
  40. ncbi request reprint Arterial stiffness and endothelial dysfunction in HIV-infected children
    Damien Bonnet
    Department of Pediatrics, Hopital Necker Enfants Malades, AP HP, and INSERM EMI 0016, Faculte de Medecine Necker Enfants Malades, Paris, France
    AIDS 18:1037-41. 2004
    ..The role of antiretroviral therapy in acceleration of atherosclerosis in HIV-infected adults is controversial, partly because of the confounding effects of the involvement of classic cardiovascular risk factors...
  41. doi request reprint [Tolerance of antiretroviral drugs during pregnancy]
    Stephane Blanche
    Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Université Paris Cité Sorbonne, Institut Imagine, Paris, France
    Med Sci (Paris) 29:383-8. 2013
    ..Genotoxic profile of zidovudine, and more generally that of antiretroviral nucleoside analogues for mitochondrial and/or nuclear DNA is certainly the main questions regarding the potential long-term effects to the child...
  42. doi request reprint Clinical similarities and differences of patients with X-linked lymphoproliferative syndrome type 1 (XLP-1/SAP deficiency) versus type 2 (XLP-2/XIAP deficiency)
    Jana Pachlopnik Schmid
    INSERM Unité 768, Laboratoire du Développement Normal et Pathologique du Système Immunitaire, Hopital Necker Enfants Malades, Paris, France
    Blood 117:1522-9. 2011
    ..This first phenotypic comparison of XLP subtypes should help to improve the diagnosis and the care of patients with XLP conditions...
  43. doi request reprint Influence of development, HIV infection, and antiretroviral therapies on the gene expression profiles of ABC transporters in human lymphocytes
    Carole Giraud
    Centre de Recherche Clinique Paris Descartes, Groupe Hospitalier Cochin Saint Vincent De Paul, Assistance Publique Hopitaux de Paris, Site Hôpital Tarnier, 75006 Paris, France
    J Clin Pharmacol 50:226-30. 2010
    ..Neither HIV infection nor antiretroviral therapies modulated the gene expression profiles of ABC transporters. In conclusion, drugs that are substrates of BCRP and MRP4, like zidovudine, may have an altered efficacy in newborns...
  44. doi request reprint Missed opportunities for HIV testing in pregnant women and children living in France
    Pierre Frange
    From the Unité d Immunologie, Hématologie et Rhumatologie pédiatriques, AP HP, Hôpital Necker Enfants Malades EA3620, Universite Paris Descartes, Sorbonne Paris Cité and Laboratoire de Virologie, AP HP, Hopital Necker Enfants Malades, Paris, France
    Pediatr Infect Dis J 33:e60-2. 2014
    ..5%). HIV testing of immigrant children were performed late after arrival, despite prompt access to healthcare structures. HIV testing strategies need to be improved. ..
  45. ncbi request reprint Burkholderia pseudomallei infection in chronic granulomatous disease
    Raffaele Renella
    Unité d Immunologie et Hématologie Pédiatrique, Hopital Necker Enfants Malades, AP HP, Paris, France
    Eur J Pediatr 165:175-7. 2006
    ..pseudomallei are still unknown. Our report suggests that CGD should be suspected in children with melioidosis, both in the Americas and probably in other regions world-wide...
  46. doi request reprint Cutaneous hematologic disorders in children
    Olivia Boccara
    Department of Pathology, Hopital Necker Enfants Malades, AP HP, Universite Rene Descartes, Paris V, France
    Pediatr Blood Cancer 58:226-32. 2012
    ..To determine and list the clinical and pathological features of cutaneous hematologic diseases in childhood...
  47. ncbi request reprint Primary cutaneous Epstein-Barr virus-related lymphoproliferative disorders in 4 immunosuppressed children
    Nadège Wallet-Faber
    Department of Pathology, Groupe Hospitalier Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Paris, France
    J Am Acad Dermatol 58:74-80. 2008
    ..The two T-cell types were also Epstein-Barr virus positive, which is extremely rare. Three of the patients developed extracutaneous disease with poor outcome, resulting in death...
  48. ncbi request reprint Allogeneic bone marrow transplantation in mevalonic aciduria
    Benedicte Neven
    Unité d Immuno Hématologie et Rhumatologie Pédiatrique, Assistance Publique Hopitaux de Paris, Paris, France
    N Engl J Med 356:2700-3. 2007
    ..We observed sustained remission of febrile attacks and inflammation during a 15-month follow-up period...
  49. ncbi request reprint [Pediatric HIV infections in developed countries: current situation and future challenges]
    Pierre Frange
    Unite d immunologie, Hématologie et Rhumatologie pédiatriques, Assistance Publique Hopitaux de Paris AP HP, Hopital Necker Enfants Malades, 149, rue de Sevres, 75015 Paris, France EA 3620, Universite Paris Descartes, Sorbonne Paris Cité, Paris, France Laboratoire de Microbiologie, Assistance Publique Hopitaux de Paris AP HP, Hopital Necker Enfants Malades, 149, rue de Sevres, 75015 Paris, France
    Med Sci (Paris) 30:551-7. 2014
    ..Future challenges will imply to study to what extent very early ART in infants may alter the establishment of HIV infection and improve the long-term immunological and virological outcome of these children. ..
  50. ncbi request reprint Corynebacterium pseudotuberculosis necrotizing lymphadenitis in a twelve-year-old patient
    Olivier F Join-Lambert
    Laboratoire de Microbiologie, Hopital Necker Enfants Malades, and Faculté de Médecine Descartes Paris, Paris, France
    Pediatr Infect Dis J 25:848-51. 2006
    ..The isolate was highly susceptible to antibiotics but only ciprofloxacin, rifampin and gentamicin exerted bactericidal activity...
  51. doi request reprint Thromboxane synthase mutations in an increased bone density disorder (Ghosal syndrome)
    David Genevieve
    Département de génétique, Unité INSERM U781, Universite Paris Descartes, Assistance Publique Hopitaux de Paris AP HP, Hopital Necker Enfants Malades, 149, rue de Sevres, 75015 Paris, France
    Nat Genet 40:284-6. 2008
    ..We also found that TXAS and TXA(2) modulated expression of TNFSF11 and TNFRSF11B (encoding RANKL and osteoprotegerin (OPG), respectively) in primary cultured osteoblasts...
  52. doi request reprint A survey of 90 patients with autoimmune lymphoproliferative syndrome related to TNFRSF6 mutation
    Benedicte Neven
    Inserm U768, Hopital Necker Enfants Malades, Paris, France
    Blood 118:4798-807. 2011
    ..We also noted a significantly greater occurrence of disease-related symptoms in male than in female patients...
  53. ncbi request reprint Kaposi's sarcoma in a child with Wiskott-Aldrich syndrome
    Capucine Picard
    Unité d Immunologie et d Hématologie Pédiatriques AP HP, Hopital Necker Enfants Malades, 149 rue de Sevres, 75015, Paris, EU, France
    Eur J Pediatr 165:453-7. 2006
    ..Kaposi's sarcoma (KS) is rare in childhood. It may be favored by acquired immune deficiencies, but the predisposing factors to KS in other children are unclear...
  54. pmc Adenoviral infection presenting as an isolated central nervous system disease without detectable viremia in two children after stem cell transplantation
    Pierre Frange
    Unite d immunologie, Hématologie et Rhumatologie pédiatriques, Hopital Necker Enfants Malades, 149 rue de Sevres, 75015 Paris, France
    J Clin Microbiol 49:2361-4. 2011
    ....
  55. ncbi request reprint Progressive neurologic dysfunctions 20 years after allogeneic bone marrow transplantation for Chediak-Higashi syndrome
    Marc Tardieu
    Service de Neurologie, Département de Pédiatrie et Laboratoire de Neuropathologie, Hopital Bicetre, Assistance Publique Hopitaux de Paris, Paris, France
    Blood 106:40-2. 2005
    ..We also reviewed the very long-term outcome of the other 11 patients with Chediak-Higashi syndrome who had received bone marrow transplants at our center since 1981. All displayed neurologic deficits or low cognitive abilities...
  56. ncbi request reprint Children's views on their involvement in clinical research
    Helene Chappuy
    Département d Urgences Pédiatriques, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris et Laboratoire d Ethique Médicale Université René Descartes Paris, France
    Pediatr Blood Cancer 50:1043-6. 2008
    ..To examine the level of children's understanding of informed consent in clinical trials and factors that may influence these processes...
  57. pmc Frequencies of ex vivo-activated human immunodeficiency virus type 1-specific gamma-interferon-producing CD8+ T cells in infected children correlate positively with plasma viral load
    Florence Buseyne
    Laboratoire d Immunopathologie Virale, Département de Médecine Moléculaire, URA CNRS 1930, Institut Pasteur, 28 rue du Dr Roux, 75015 Paris, France
    J Virol 76:12414-22. 2002
    ..In conclusion, our results show that the ex vivo-activated IFN-gamma-producing HIV-specific CD8+ T-cell subset is dependent upon continuous antigenic stimulation...
  58. ncbi request reprint [Mother-to-child transmission (MTCT) of HIV]
    Pierre Frange
    AP HP, Hopital Necker Enfants Malades, Laboratoire de Microbiologie, 75015 Paris, France AP HP, Hopital Necker Enfants Malades, Unite d immunologie, Hématologie et Rhumatologie pédiatriques, 75015 Paris, France EA 3620, Universite Paris Descartes, Sorbonne Paris Cité, 75006 Paris, France Electronic address
    Presse Med 43:691-7. 2014
    ....
  59. pmc Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I
    Anne Puel
    Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Sante et de la Recherche Medicale INSERM, U550, 75015 Paris, France
    J Exp Med 207:291-7. 2010
    ..These findings suggest that auto-Abs against IL-17A, IL-17F, and IL-22 may cause CMC in patients with APS-I...
  60. pmc Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis
    Luyan Liu
    Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Necker Medical School, Institut National de la Santé et de la Recherche Médicale U980 and University Paris Descartes, 75015 Paris, France
    J Exp Med 208:1635-48. 2011
    ..Gain-of-function STAT1 alleles therefore cause AD CMCD by impairing IL-17 immunity...
  61. pmc Monitoring cytomegalovirus infection in adult and pediatric bone marrow transplant recipients by a real-time PCR assay performed with blood plasma
    Marianne Leruez-Ville
    Laboratoire de Virologie, CHU Necker Enfants Malades, 75015 Paris, France
    J Clin Microbiol 41:2040-6. 2003
    ....