Francois Blachier

Summary

Country: France

Publications

  1. doi request reprint Metabolism and functions of L-glutamate in the epithelial cells of the small and large intestines
    Francois Blachier
    INRA, CRNH IdF, UMR Nutrition Physiology and Ingestive Behavior, Paris, France
    Am J Clin Nutr 90:814S-821S. 2009
  2. ncbi request reprint Channelling of arginine in NO and polyamine pathways in colonocytes and consequences
    Francois Blachier
    INRA, AgroParisTech, CRNH IdF, UMR 914 Nutrition Physiology and Ingestive Behavior, 16 rue Claude Bernard, Paris, France
    Front Biosci (Landmark Ed) 16:1331-43. 2011
  3. doi request reprint Luminal sulfide and large intestine mucosa: friend or foe?
    Francois Blachier
    INRA, AgroParisTech, CRNH IdF, UMR 914 Nutrition Physiology and Ingestive Behavior, Paris, France
    Amino Acids 39:335-47. 2010
  4. doi request reprint Alimentary proteins, amino acids and cholesterolemia
    Francois Blachier
    INRA, CNRH IdF, AgroParisTech, UMR 914 Nutrition Physiology and Ingestive Behavior, Paris, France
    Amino Acids 38:15-22. 2010
  5. doi request reprint Detoxification of H(2)S by differentiated colonic epithelial cells: implication of the sulfide oxidizing unit and of the cell respiratory capacity
    Sabria Mimoun
    INRA CRNH IdF AgroParisTech, UMR 914 Nutrition Physiology and Ingestive Behavior, Paris, France
    Antioxid Redox Signal 17:1-10. 2012
  6. ncbi request reprint Decreased glutamate, glutamine and citrulline concentrations in plasma and muscle in endotoxemia cannot be reversed by glutamate or glutamine supplementation: a primary intestinal defect?
    Claire Boutry
    INRA, CNRH IdF, UMR914 Nutrition Physiology and Ingestive Behavior, 16 rue Claude Bernard, 75005 Paris, France
    Amino Acids 43:1485-98. 2012
  7. ncbi request reprint Effects of monosodium glutamate supplementation on glutamine metabolism in adult rats
    Claire Boutry
    INRA, CNRH IdF, UMR 914 Nutrition Physiology and Ingestive Behavior, Paris, France
    Front Biosci (Elite Ed) 3:279-90. 2011
  8. doi request reprint Colon luminal content and epithelial cell morphology are markedly modified in rats fed with a high-protein diet
    Mireille Andriamihaja
    Institut National de Recherche Agronomique, AgroParisTech, Centre de Recherche en Nutrition Humaine Ile de France, UMR 914 Physiologie de Nutrition et du Comportement Alimentaire, Paris, France
    Am J Physiol Gastrointest Liver Physiol 299:G1030-7. 2010
  9. doi request reprint Intestinal luminal nitrogen metabolism: role of the gut microbiota and consequences for the host
    Anne Marie Davila
    UMR 914 INRA AgroParisTech, Nutrition Physiology and Ingestive Behavior, Paris, France
    Pharmacol Res 68:95-107. 2013
  10. doi request reprint Lactose malabsorption and colonic fermentations alter host metabolism in rats
    Virginie Alexandre
    AgroParisTech, UMR 914, CRNH IdF, Nutrition Physiology and Ingestive Behavior Department, 16 rue Claude Bernard, 75005 Paris, France
    Br J Nutr 110:625-31. 2013

Collaborators

Detail Information

Publications24

  1. doi request reprint Metabolism and functions of L-glutamate in the epithelial cells of the small and large intestines
    Francois Blachier
    INRA, CRNH IdF, UMR Nutrition Physiology and Ingestive Behavior, Paris, France
    Am J Clin Nutr 90:814S-821S. 2009
    ..l-Glutamate can then serve in the colon lumen as a precursor for butyrate and acetate in bacteria. l-Glutamate, in addition to fiber and digestion-resistant starch, can thus serve as a luminally derived fuel precursor for colonocytes...
  2. ncbi request reprint Channelling of arginine in NO and polyamine pathways in colonocytes and consequences
    Francois Blachier
    INRA, AgroParisTech, CRNH IdF, UMR 914 Nutrition Physiology and Ingestive Behavior, 16 rue Claude Bernard, Paris, France
    Front Biosci (Landmark Ed) 16:1331-43. 2011
    ..Unbalance of the chanelling of arginine in the NO and polyamine pathways in colonic cancerous epithelial cells as a determinant promoting their proliferation is discussed...
  3. doi request reprint Luminal sulfide and large intestine mucosa: friend or foe?
    Francois Blachier
    INRA, AgroParisTech, CRNH IdF, UMR 914 Nutrition Physiology and Ingestive Behavior, Paris, France
    Amino Acids 39:335-47. 2010
    ..Lastly, sulfide has been recently described as an agent involved in nociception in the large intestine although, depending on the experimental design, both pro- and anti-nociceptive effects have been reported...
  4. doi request reprint Alimentary proteins, amino acids and cholesterolemia
    Francois Blachier
    INRA, CNRH IdF, AgroParisTech, UMR 914 Nutrition Physiology and Ingestive Behavior, Paris, France
    Amino Acids 38:15-22. 2010
    ..It is however not known if these results are relevant to human nutrition...
  5. doi request reprint Detoxification of H(2)S by differentiated colonic epithelial cells: implication of the sulfide oxidizing unit and of the cell respiratory capacity
    Sabria Mimoun
    INRA CRNH IdF AgroParisTech, UMR 914 Nutrition Physiology and Ingestive Behavior, Paris, France
    Antioxid Redox Signal 17:1-10. 2012
    ..Deciphering how colonocytes metabolize sulfide is an important issue...
  6. ncbi request reprint Decreased glutamate, glutamine and citrulline concentrations in plasma and muscle in endotoxemia cannot be reversed by glutamate or glutamine supplementation: a primary intestinal defect?
    Claire Boutry
    INRA, CNRH IdF, UMR914 Nutrition Physiology and Ingestive Behavior, 16 rue Claude Bernard, 75005 Paris, France
    Amino Acids 43:1485-98. 2012
    ..The implication of a loss of the intestinal capacity for AA absorption and/or metabolism in endotoxemia (as judged from decreased citrulline plasma concentration) for explaining such results are discussed...
  7. ncbi request reprint Effects of monosodium glutamate supplementation on glutamine metabolism in adult rats
    Claire Boutry
    INRA, CNRH IdF, UMR 914 Nutrition Physiology and Ingestive Behavior, Paris, France
    Front Biosci (Elite Ed) 3:279-90. 2011
    ..It is concluded that MSG chronic supplementation promotes glutamine synthesis in the body but has little effect on the physiological functions examined...
  8. doi request reprint Colon luminal content and epithelial cell morphology are markedly modified in rats fed with a high-protein diet
    Mireille Andriamihaja
    Institut National de Recherche Agronomique, AgroParisTech, Centre de Recherche en Nutrition Humaine Ile de France, UMR 914 Physiologie de Nutrition et du Comportement Alimentaire, Paris, France
    Am J Physiol Gastrointest Liver Physiol 299:G1030-7. 2010
    ..Possible causal relationships between energy metabolism, reduced height of colonocyte brush-border membranes, and reduced water absorption are discussed...
  9. doi request reprint Intestinal luminal nitrogen metabolism: role of the gut microbiota and consequences for the host
    Anne Marie Davila
    UMR 914 INRA AgroParisTech, Nutrition Physiology and Ingestive Behavior, Paris, France
    Pharmacol Res 68:95-107. 2013
    ..More work is needed to clarify the overall effects of the intestinal microbiota on nitrogenous compound metabolism and consequences on gut and more generally host health...
  10. doi request reprint Lactose malabsorption and colonic fermentations alter host metabolism in rats
    Virginie Alexandre
    AgroParisTech, UMR 914, CRNH IdF, Nutrition Physiology and Ingestive Behavior Department, 16 rue Claude Bernard, 75005 Paris, France
    Br J Nutr 110:625-31. 2013
    ..These results underline the consequences of acute lactose malabsorption and measured compensations occurring in the host's metabolism, presumably through the microbiota fermentations and microbiota-host interactions...
  11. doi request reprint Colonic luminal ammonia and portal blood L-glutamine and L-arginine concentrations: a possible link between colon mucosa and liver ureagenesis
    Mamy Eklou-Lawson
    INRA, CNRH IdF, AgroParisTech, UMR 914 Nutrition Physiology and Ingestive Behavior, 16 rue Claude Bernard, 75005, Paris, France
    Amino Acids 37:751-60. 2009
    ....
  12. doi request reprint Butyrate metabolism in human colon carcinoma cells: implications concerning its growth-inhibitory effect
    Mireille Andriamihaja
    INRA, CNRH IdF, UMR 914 Nutrition Physiology and Ingestive Behavior, Paris, France
    J Cell Physiol 218:58-65. 2009
    ..The suggestion that butyrate metabolism in mitochondria is not used in these cells as a fuel but acts as a regulator of butyrate free concentrations (thus limiting its action upon cellular targets), is discussed...
  13. doi request reprint Re-print of "Intestinal luminal nitrogen metabolism: Role of the gut microbiota and consequences for the host"
    Anne Marie Davila
    UMR 914 INRA AgroParisTech, Nutrition Physiology and Ingestive Behavior, Paris, France Electronic address
    Pharmacol Res 69:114-26. 2013
    ..More work is needed to clarify the overall effects of the intestinal microbiota on nitrogenous compound metabolism and consequences on gut and more generally host health...
  14. doi request reprint Comparative efficiency of microbial enzyme preparations versus pancreatin for in vitro alimentary protein digestion
    Mireille Andriamihaja
    INRA, CNRH IdF, AgroParisTech, UMR 914 Nutrition Physiology and Ingestive Behaviour, 16 rue Claude Bernard, 75005 Paris, France
    Amino Acids 44:563-72. 2013
    ....
  15. ncbi request reprint Sulfide, the first inorganic substrate for human cells
    Marc Goubern
    Ecole Pratique des Hautes Etudes and Nurélice UR909, INRA, F 78352 Jouy en Josas, France
    FASEB J 21:1699-706. 2007
    ..In conclusion, this work provides additional and compelling evidence that sulfide is not only a toxic compound. According to our study, sulfide appears to be the first inorganic substrate for mammalian cells characterized thus far...
  16. doi request reprint Monosodium glutamate raises antral distension and plasma amino acid after a standard meal in humans
    Claire Boutry
    INRA, Research Center for Human Nutrition IdF, UMR914, Paris, France
    Am J Physiol Gastrointest Liver Physiol 300:G137-45. 2011
    ..Further work to elucidate the possible sparing effect of MSG on indispensable amino acid first-pass uptake in humans is warranted. This trial was registered at clinicaltrials.gov as NCT00862017...
  17. doi request reprint Beneficial effects of an amino acid mixture on colonic mucosal healing in rats
    Xinxin Liu
    UMR 914 PNCA INRA, AgroParisTech Physiologie de la Nutrition et du Comportement Alimentaire, Paris, France Service d Anatomie et Cytologie Pathologique, Hôpital Xavier Bichat, Paris, France INSERM U773, Centre de Recherche Biomédicale Bichat Beaujon Université Paris 7, Paris, France Frontier Research Laboratory, Institute for Innovation, Ajinomoto Co Inc, Kawasaki, Japan and Departement de Gastroentérologie, Hopital Avicenne, Assistance Publique Hopitaux de Paris, Bobigny, France
    Inflamm Bowel Dis 19:2895-905. 2013
    ..Here, we investigated the effect of an amino acid mixture supplement on rat MH...
  18. pmc Rapeseed and milk protein exhibit a similar overall nutritional value but marked difference in postprandial regional nitrogen utilization in rats
    Claire Boutry
    INRA, CNRH IdF, UMR914 Nutrition Physiology and Ingestive Behavior, F 75005 Paris, France
    Nutr Metab (Lond) 8:52. 2011
    ..abstract:..
  19. doi request reprint Mitochondria and sulfide: a very old story of poisoning, feeding, and signaling?
    Frederic Bouillaud
    Institut Cochin, Universite Paris Descartes, Inserm U1016, CNRS UMR8104, Paris, France
    Antioxid Redox Signal 15:379-91. 2011
    ..Finally, we offer perspectives for future studies on the relationship between the two opposing aspects of this Janus-type molecule, sulfide...
  20. doi request reprint Butyrate utilization by the colonic mucosa in inflammatory bowel diseases: a transport deficiency
    Ronan Thibault
    UMR 1280 Physiologie des Adaptations Nutritionnelles, INRA, Universite de Nantes, CHU Nantes, Nantes, France
    Inflamm Bowel Dis 16:684-95. 2010
    ..Butyrate transport deficiency is expected to have clinical consequences. Particularly, the reduction of the intracellular availability of butyrate in colonocytes may decrease its protective effects toward cancer in IBD patients...
  21. doi request reprint Effects of galacto-oligosaccharide ingestion on the mucosa-associated mucins and sucrase activity in the small intestine of mice
    Géraldine Leforestier
    INRA, CRNH IdF, UMR914 Nutrition Physiology and Ingestive Behavior, 16 rue Claude Bernard, 75005, Paris, France
    Eur J Nutr 48:457-64. 2009
    ..Only few studies have investigated the effects of GOS medium-term ingestion on the small intestinal epithelium characteristics...
  22. ncbi request reprint PL11 Sulfide and mitochondrial bioenergetics
    Frederic Bouillaud
    Inserm U1016, CNRS UMR8104, Universite Paris Descartes, Paris, France
    Nitric Oxide 31:S15-6. 2013
    ..The mechanisms involved in mitochondrial sulfide bioenergetics as well as their consequences with regard to the signaling role of sulfide and to the use of sulfide donors will be explained. ..
  23. ncbi request reprint [Dietary fibers and colorectal cancer. Experimental studies, epidemiology, mechanisms]
    Pierre Astorg
    UMR Epidémiologie Nutritionnelle INSERM U557 INRA CNAM, Conservatoire National des Arts et Metiers, Paris, France
    Gastroenterol Clin Biol 26:893-912. 2002
  24. doi request reprint Development of animal models and sandwich-ELISA tests to detect the allergenicity and antigenicity of fining agent residues in wines
    Awatif Lifrani
    INRA, CRNH IdF, UMR Nutrition Physiology and Ingestive Behavior, Paris, France
    J Agric Food Chem 57:525-34. 2009
    ..Commercially available bottled wines made using standardized processes, fining, maturation, and filtration, do not therefore represent any risk of anaphylactic reactions in sensitized mice...