Nathalie Billon

..They suggest that the adipose tissue is composed of distinct mini-organs, exhibiting developmental and functional differences, as well as variable contribution to obesity-related metabolic diseases...

..Finally, we mapped NC derivatives in vivo using Cre-mediated recombination in transgenic mice and demonstrated that a subset of adipocytes originates from the NC during normal development...

..This is the first evidence for a role of p73 in the differentiation of a normal mammalian cell...

..While major progress has been made in defining the molecular networks that control adipocyte terminal differentiation, the early steps of adipocyte development and the embryonic origin of this lineage remain largely unknown...

..This review summarizes the surprising findings that have recently emerged from both embryonic stem cells and lineage-tracing studies in vivo, unravelling an unsuspected developmental origin for MSCs and adipocytes in the neural crest...

..It may also be useful for producing OPCs and oligodendrocytes from human ES cells for cell therapy and drug screening...

..Our results suggest that although RARbeta and active GSK3 are required for RA-induced adipogenesis, they might be acting through a Wnt pathway-independent mechanism...

..This strategy may also be useful for producing human cells for therapy and drug screening...

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..Finally, we provide evidence that the inhibitory isoforms of TRalpha are unlikely to play a part in the timing of OPC differentiation...

..Taken together, our data demonstrate that nucleofection allows both transient and stable gene expression in adipose tissue-derived stem cells, without impairing their differentiation potential...

..These results show that loss of pluripotency (and lineage choice) is associated with extensive and predictable changes in the replication timing of key regulator genes...