Ivan Bieche

Summary

Country: France

Publications

  1. pmc Gene expression profiling reveals new aspects of PIK3CA mutation in ERalpha-positive breast cancer: major implication of the Wnt signaling pathway
    Magdalena Cizkova
    Laboratoire d oncogénétique, Institut National de la Santé et de la Recherche, U745, Institut Curie Hôpital René Huguenin, St Cloud, France
    PLoS ONE 5:e15647. 2010
  2. ncbi Molecular profiling of inflammatory breast cancer: identification of a poor-prognosis gene expression signature
    Ivan Bieche
    Laboratoire d Oncogénétique INSERM E0017, Centre Rene Huguenin, St Cloud, France
    Clin Cancer Res 10:6789-95. 2004
  3. pmc Prognostic value of maspin mRNA expression in ER alpha-positive postmenopausal breast carcinomas
    I Bieche
    Laboratoire d oncogénétique, INSERM E0017, 35 rue Dailly, Centre Rene Huguenin, St Cloud, France
    Br J Cancer 88:863-70. 2003
  4. pmc Identification of 5 novel genes methylated in breast and other epithelial cancers
    Victoria K Hill
    Department of Medical and Molecular Genetics, University of Birmingham, UK
    Mol Cancer 9:51. 2010
  5. pmc Identification of a three-gene expression signature of poor-prognosis breast carcinoma
    Ivan Bieche
    Laboratoire d Oncogénétique INSERM E0017, Centre Rene Huguenin, St Cloud, France
    Mol Cancer 3:37. 2004
  6. pmc Relationship between intratumoral expression of genes coding for xenobiotic-metabolizing enzymes and benefit from adjuvant tamoxifen in estrogen receptor alpha-positive postmenopausal breast carcinoma
    Ivan Bieche
    Laboratoire d Oncogénétique INSERM E0017, Centre Rene Huguenin, St Cloud, France
    Breast Cancer Res 6:R252-63. 2004
  7. pmc A candidate molecular signature associated with tamoxifen failure in primary breast cancer
    Julie A Vendrell
    Universite de Lyon, Faculté de Pharmacie de Lyon, France
    Breast Cancer Res 10:R88. 2008
  8. pmc Isolation of mineralizing Nestin+ Nkx6.1+ vascular muscular cells from the adult human spinal cord
    Daria Mamaeva
    CNRS UPR 1142, Institute of Human Genetics, 141, rue de la Cardonille, 34396 Montpellier Cedex 05, France
    BMC Neurosci 12:99. 2011
  9. ncbi Expression analysis of estrogen receptor alpha coregulators in breast carcinoma: evidence that NCOR1 expression is predictive of the response to tamoxifen
    Igor Girault
    Laboratoire d oncogénétique, Institut National de la Santé et de la Recherche Médicale E0017, Centre Rene Huguenin, F 92211 St Cloud, France
    Clin Cancer Res 9:1259-66. 2003
  10. pmc PIK3CA mutation impact on survival in breast cancer patients and in ERα, PR and ERBB2-based subgroups
    Magdalena Cizkova
    Laboratoire d oncogénétique, Institut Curie, Hôpital René Huguenin, 35 rue Dailly, Saint Cloud, F 92210, France
    Breast Cancer Res 14:R28. 2012

Collaborators

Detail Information

Publications35

  1. pmc Gene expression profiling reveals new aspects of PIK3CA mutation in ERalpha-positive breast cancer: major implication of the Wnt signaling pathway
    Magdalena Cizkova
    Laboratoire d oncogénétique, Institut National de la Santé et de la Recherche, U745, Institut Curie Hôpital René Huguenin, St Cloud, France
    PLoS ONE 5:e15647. 2010
    ..PIK3CA mutations have been observed in 30% to 40% of ERα-positive breast tumors. However the physiopathological role of PIK3CA mutations in breast tumorigenesis remains largely unclear...
  2. ncbi Molecular profiling of inflammatory breast cancer: identification of a poor-prognosis gene expression signature
    Ivan Bieche
    Laboratoire d Oncogénétique INSERM E0017, Centre Rene Huguenin, St Cloud, France
    Clin Cancer Res 10:6789-95. 2004
    ..Inflammatory breast cancer (IBC) is a rare but particularly aggressive form of primary breast cancer. The molecular mechanisms responsible for IBC are largely unknown...
  3. pmc Prognostic value of maspin mRNA expression in ER alpha-positive postmenopausal breast carcinomas
    I Bieche
    Laboratoire d oncogénétique, INSERM E0017, 35 rue Dailly, Centre Rene Huguenin, St Cloud, France
    Br J Cancer 88:863-70. 2003
    ..0024). These findings show that the maspin mRNA level can have important prognostic significance in human breast cancer, and point to the maspin gene as a putative molecular predictor of hormone responsiveness in breast cancer...
  4. pmc Identification of 5 novel genes methylated in breast and other epithelial cancers
    Victoria K Hill
    Department of Medical and Molecular Genetics, University of Birmingham, UK
    Mol Cancer 9:51. 2010
    ..We utilized one such recently developed approach, MIRA (methylated-CpG island recovery assay) combined with CpG island arrays to identify novel genes that are epigenetically inactivated in breast cancer...
  5. pmc Identification of a three-gene expression signature of poor-prognosis breast carcinoma
    Ivan Bieche
    Laboratoire d Oncogénétique INSERM E0017, Centre Rene Huguenin, St Cloud, France
    Mol Cancer 3:37. 2004
    ..The use of gene expression profiles could result in more accurate and objective prognostication...
  6. pmc Relationship between intratumoral expression of genes coding for xenobiotic-metabolizing enzymes and benefit from adjuvant tamoxifen in estrogen receptor alpha-positive postmenopausal breast carcinoma
    Ivan Bieche
    Laboratoire d Oncogénétique INSERM E0017, Centre Rene Huguenin, St Cloud, France
    Breast Cancer Res 6:R252-63. 2004
    ..One molecular mechanism proposed to explain tamoxifen resistance is altered tamoxifen metabolism and bioavailability...
  7. pmc A candidate molecular signature associated with tamoxifen failure in primary breast cancer
    Julie A Vendrell
    Universite de Lyon, Faculté de Pharmacie de Lyon, France
    Breast Cancer Res 10:R88. 2008
    ..Identification of such markers would be clinically useful. We attempted to identify molecular markers associated with tamoxifen failure in breast cancer...
  8. pmc Isolation of mineralizing Nestin+ Nkx6.1+ vascular muscular cells from the adult human spinal cord
    Daria Mamaeva
    CNRS UPR 1142, Institute of Human Genetics, 141, rue de la Cardonille, 34396 Montpellier Cedex 05, France
    BMC Neurosci 12:99. 2011
    ..We previously isolated Nestin+ Sox2+ neural multipotential cells from the adult human spinal cord using the neurosphere method (i.e. non adherent conditions and defined medium)...
  9. ncbi Expression analysis of estrogen receptor alpha coregulators in breast carcinoma: evidence that NCOR1 expression is predictive of the response to tamoxifen
    Igor Girault
    Laboratoire d oncogénétique, Institut National de la Santé et de la Recherche Médicale E0017, Centre Rene Huguenin, F 92211 St Cloud, France
    Clin Cancer Res 9:1259-66. 2003
    ..Therefore, expression analysis of these ERalpha coregulators may identify new predictors of the response to tamoxifen treatment...
  10. pmc PIK3CA mutation impact on survival in breast cancer patients and in ERα, PR and ERBB2-based subgroups
    Magdalena Cizkova
    Laboratoire d oncogénétique, Institut Curie, Hôpital René Huguenin, 35 rue Dailly, Saint Cloud, F 92210, France
    Breast Cancer Res 14:R28. 2012
    ..PIK3CA is the oncogene showing the highest frequency of gain-of-function mutations in breast cancer, but the prognostic value of PIK3CA mutation status is controversial...
  11. pmc NF-kappa B genes have a major role in inflammatory breast cancer
    Florence Lerebours
    Centre Rene Huguenin, FNCLCC, 35 rue Dailly, 92210, St Cloud, France
    BMC Cancer 8:41. 2008
    ..Given the role of NF-kappaB-related genes in cell proliferation, invasiveness, angiogenesis and inflammation, we postulated that they might be deregulated in IBC...
  12. doi miRNA expression profiling of inflammatory breast cancer identifies a 5-miRNA signature predictive of breast tumor aggressiveness
    Florence Lerebours
    Laboratoire d oncogénétique, Institut Curie, Hôpital René Huguenin, 35 rue Dailly, Saint Cloud, France
    Int J Cancer 133:1614-23. 2013
    ..Moreover, multivariate analysis showed that this signature was an independent predictor of poor Metastasis-Free Survival in non-IBC patients. ..
  13. ncbi Exemestane as neoadjuvant hormonotherapy for locally advanced breast cancer: results of a phase II trial
    Michele Tubiana-Hulin
    Departments of Medical Oncology, Centre Rene Huguenin, 35 rue daily, 92210 St Cloud, France
    Anticancer Res 27:2689-96. 2007
    ..Neoadjuvant hormonotherapy has recently been used for downstaging large or locally advanced (LA) breast cancer in postmenopausal women...
  14. ncbi Altered expression pattern of alternatively spliced estrogen receptor beta transcripts in breast carcinoma
    Igor Girault
    Laboratoire d Oncogénétique INSERM E0017, Centre Rene Huguenin, F 92211 St Cloud, France
    Cancer Lett 215:101-12. 2004
    ..This altered expression pattern of ERbeta isoforms in breast cancer should be taken into account in future ERbeta-based clinical applications...
  15. doi DNA repair gene expression and risk of locoregional relapse in breast cancer patients
    Romuald Le Scodan
    Department of Radiation Oncology, Centre Rene Huguenin, Saint Cloud, France
    Int J Radiat Oncol Biol Phys 78:328-36. 2010
    ..Radiation therapy appears to kill cells mainly by inducing DNA double-strand breaks. We investigated whether the DNA repair gene expression status might influence the risk of locoregional recurrence (LRR) in breast cancer patients...
  16. ncbi Two prognostic groups of inflammatory breast cancer have distinct genotypes
    Florence Lerebours
    Institut National de la Santé et de la Recherche Médicale INSERM E0017 Oncogénétique, Centre Rene Huguenin, 35 rue Dailly, F 92211 St Cloud, France
    Clin Cancer Res 9:4184-9. 2003
    ..Analysis of loss of heterozygosity (LOH) can provide a molecular portrait of the genetic alterations underlying stepwise cancer progression. We tested the value of LOH patterns as diagnostic and prognostic markers in IBC...
  17. ncbi Role of estrogen receptor alpha transcriptional coregulators in tamoxifen resistance in breast cancer
    Igor Girault
    Centre Rene Huguenin, FNCLCC, INSERM, U735, F 92210, St Cloud, France
    Maturitas 54:342-51. 2006
    ..Many altered pathways may account for tamoxifen resistance which may be best studied by multigene approaches...
  18. doi Role of the focal adhesion protein kindlin-1 in breast cancer growth and lung metastasis
    Soraya Sin
    Institut Curie, Laboratoire d oncogénétique, Hôpital René Huguenin, 35 rue Dailly, Saint Cloud, 92210, France
    J Natl Cancer Inst 103:1323-37. 2011
    ..However, the possible role of kindlin-1 in cancer remains unknown...
  19. ncbi Expression of PEA3/E1AF/ETV4, an Ets-related transcription factor, in breast tumors: positive links to MMP2, NRG1 and CGB expression
    Ivan Bieche
    Laboratoire d Oncogénétique INSERM E0017, Centre Rene Huguenin, St Cloud, France
    Carcinogenesis 25:405-11. 2004
    ..Taken together, the data confirm the role of the PEA3 gene in breast tumorigenesis, and suggest the existence of numerous other still unknown genes transactivated by the PEA3 transcription factor...
  20. pmc Expression analysis of mitotic spindle checkpoint genes in breast carcinoma: role of NDC80/HEC1 in early breast tumorigenicity, and a two-gene signature for aneuploidy
    Ivan Bieche
    INSERM U735, Institut Curie Hôpital René Huguenin, St Cloud, France
    Mol Cancer 10:23. 2011
    ..Alterations of the mitotic spindle checkpoint are likely to contribute to these phenotypes, but little is known about somatic alterations of mitotic spindle checkpoint genes in breast cancer...
  21. pmc Identification of new candidate therapeutic target genes in triple-negative breast cancer
    Mathilde Glénisson
    Laboratory of Oncogenetic, Institut Curie, Hôpital René Huguenin, St Cloud, France
    Genes Cancer 3:63-70. 2012
    ..Clinical trials could be initiated easily with existing drugs. Our results also suggest that these target genes might serve as predictive biomarkers of the TNBC treatment response...
  22. ncbi Prognostic value of ERBB family mRNA expression in breast carcinomas
    Ivan Bieche
    Laboratoire d Oncogénétique INSERM E0017, Centre Rene Huguenin, St Cloud, France
    Int J Cancer 106:758-65. 2003
    ....
  23. pmc Update on inflammatory breast cancer
    Florence Lerebours
    Inserm E0017 oncogénétique, Centre Rene Huguenin, St Cloud, France
    Breast Cancer Res 7:52-8. 2005
    ..A more comprehensive view will probably be obtained by pan-genomic analysis of human IBC samples, and by functional in vitro and in vivo assays. These approaches may offer better patient outcome in the near future...
  24. ncbi Prognostic value of uPA, PAI-1 and PAI-2 mRNA expression in primary breast cancer
    Frederique Spyratos
    Laboratoire d Oncobiologie, INSERM E0017, St Cloud, France
    Anticancer Res 22:2997-3003. 2002
    ..The prognostic value of uPA, PAI-1 and PAI-2 mRNA expression was studied in a retrospective series of 130 primary breast cancer patients (median follow-up 8.1 years)...
  25. doi A six-gene signature predicting breast cancer lung metastasis
    Thomas Landemaine
    Centre Rene Huguenin, Fédération Nationale des Centres de Lutte Contre le Cancer and Institut National de la Sante et de la Recherche Medicale, U735, Saint Cloud, France
    Cancer Res 68:6092-9. 2008
    ..Finally, we show that the signature improves risk stratification independently of known standard clinical variables and a previously established lung metastasis signature based on an experimental breast cancer metastasis model...
  26. doi Quantitative PCR high-resolution melting (qPCR-HRM) curve analysis, a new approach to simultaneously screen point mutations and large rearrangements: application to MLH1 germline mutations in Lynch syndrome
    Etienne Rouleau
    Centre Rene Huguenin, Laboratoire d oncogénétique, Institut Nationale de la Santé et de la Recherche Médicale INSERM U735, Saint Cloud, France
    Hum Mutat 30:867-75. 2009
    ..In replicate, its reagent cost, sensitivity, and specificity are comparable to those of dHPLC+MLPA techniques. However, qPCR HRM outperformed the other techniques in terms of its rapidity and amount of data provided...
  27. doi Variations in the mRNA expression of poly(ADP-ribose) polymerases, poly(ADP-ribose) glycohydrolase and ADP-ribosylhydrolase 3 in breast tumors and impact on clinical outcome
    Ivan Bieche
    Laboratoire d oncogénétique, Institut Curie Hôpital René Huguenin, 92210, Saint Cloud, France
    Int J Cancer 133:2791-800. 2013
    ..4%). Within the subgroup of triple negative tumors, PARG mRNA levels below the median were associated with a higher risk of developing metastases (p = 0.039) raising the possibility this might be marker of clinical outcome. ..
  28. ncbi Evidence of chromosome regions and gene involvement in inflammatory breast cancer
    Florence Lerebours
    Inserm E0017 oncogénétique, St Cloud, France
    Int J Cancer 102:618-22. 2002
    ..In contrast, the DNA amplification levels of ERBB2, MYC and CCND1, as measured by real-time quantitative PCR, did not differ between IBC and non IBC...
  29. doi Genome-based and transcriptome-based molecular classification of breast cancer
    Ivan Bieche
    Laboratoire d oncogénétique, Hôpital René Huguenin, Institut Curie, St Cloud, France
    Curr Opin Oncol 23:93-9. 2011
    ..The highly heterogeneous clinical, histological, biological and genetic nature of breast malignancies is due in part to their extreme molecular complexity...
  30. ncbi Real-time RT-PCR: a complementary method to detect HER-2 status in breast carcinoma
    Céline Bossard
    Departement de Pathologie, Centre Rene Huguenin, Saint Cloud, France
    Anticancer Res 25:4679-83. 2005
    ..These results show a high concordance rate (84%) between Q-RT-PCR and IHC (p < 10(-4)). We conclude that Q-RT-PCR is a useful complementary method for determination of the HER-2 status...
  31. ncbi Reverse transcriptase-PCR quantification of mRNA levels from cytochrome (CYP)1, CYP2 and CYP3 families in 22 different human tissues
    Ivan Bieche
    INSERM, UMR735, St Cloud, F 92210 Centre Renè Huguenin, FNCLCC, St Cloud, F 92211, France
    Pharmacogenet Genomics 17:731-42. 2007
    ....
  32. ncbi ERBB2 status and benefit from adjuvant tamoxifen in ERalpha-positive postmenopausal breast carcinoma
    I Bieche
    Laboratoire d oncogénétique, INSERM E0017, 35 rue Dailly, F 92211 St Cloud, France
    Cancer Lett 174:173-8. 2001
    ..00036). The results point to the need for a quantitative ERBB2 expression assay for use in future studies of ERBB2-based clinical management of breast cancer...
  33. ncbi [Detection of telomerase activity by semi-quantitative and in situ assays and quantification of hTERT expression in bladder carcinomas]
    Elisabeth Longchampt
    Laboratoire d oncogénétique, INSERM E0017, Saint Cloud, France
    Prog Urol 13:238-45. 2003
    ..The objective of this study was to detect telomerase activity by semiquantitative in situ methods and to quantify expression of the hTERT subunit in a group of bladder cancers in order to assess its diagnostic and prognostic value...
  34. ncbi Real-time reverse transcription PCR assay of CYP19 expression: application to a well-defined series of post-menopausal breast carcinomas
    I Girault
    Laboratoire d oncogénétique, INSERM E0017, Centre Rene Huguenin, 35 rue Dailly, St Cloud, F 92211 Paris, France
    J Steroid Biochem Mol Biol 82:323-32. 2002
    ..018). In conclusion, CYP19 expression did not influence the outcome of post-menopausal patients with breast cancer...
  35. ncbi Identification of novel genes that co-cluster with estrogen receptor alpha in breast tumor biopsy specimens, using a large-scale real-time reverse transcription-PCR approach
    S Tozlu
    Centre Rene Huguenin, FNCLCC, St Cloud F 92210, France
    Endocr Relat Cancer 13:1109-20. 2006
    ..Some of the genes identified here could be useful for diagnosis or for predicting endocrine responsiveness, and could form the basis for novel therapeutic strategies...