A Bianco

Summary

Country: France

Publications

  1. ncbi Carbon-nanotube shape and individualization critical for renal excretion
    Lara Lacerda
    Nanomedicine Laboratory, Centre for Drug Delivery Research The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N1AX, UK
    Small 4:1130-2. 2008
  2. ncbi Solid-phase synthesis and characterization of a novel fullerene-peptide derived from histone H3
    Alberto Bianco
    Institute of Molecular and Cellular Biology, UPR 9021 CNRS, 67084 Strasbourg, France
    Org Biomol Chem 1:4141-3. 2003
  3. ncbi Carbon nanotubes: on the road to deliver
    Alberto Bianco
    UPR 9021, CNRS, Institut de Biologie Moleculaire et Cellulaire, 15 rue Rene Descartes, F 67084, Strasbourg, France
    Curr Drug Deliv 2:253-9. 2005
  4. ncbi Cationic carbon nanotubes bind to CpG oligodeoxynucleotides and enhance their immunostimulatory properties
    Alberto Bianco
    Institut de Biologie Moleculaire et Cellulaire, UPR9021 CNRS, Immunologie et Chimie Thérapeutiques, 67084 Strasbourg, France
    J Am Chem Soc 127:58-9. 2005
  5. ncbi Solid-phase synthesis of CD40L mimetics
    Alberto Bianco
    Institut de Biologie Moleculaire et Cellulaire, UPR 9021 CNRS, Immunologie et Chimie Thérapeutiques, 15 rue Rene Descartes, 67084 Strasbourg, France
    Org Biomol Chem 4:1461-3. 2006
  6. ncbi Carbon nanotubes for the delivery of therapeutic molecules
    Alberto Bianco
    Institut de Biologie Moleculaire et Cellulaire, UPR 9021, CNRS, Immunologie et Chimie Thérapeutiques, 15 rue Rene Descartes, 67084 Strasbourg Cedex, France
    Expert Opin Drug Deliv 1:57-65. 2004
  7. ncbi Opportunities and challenges of carbon-based nanomaterials for cancer therapy
    Alberto Bianco
    CNRS, Institut de Biologie Moleculaire et Cellulaire, UPR 9021 Immonulogie et Chimie Thérapeutiques, 67000 Strasbourg, France
    Expert Opin Drug Deliv 5:331-42. 2008
  8. ncbi Fullerene-based amino acids and peptides
    A Bianco
    Laboratoire de Chimie Immunologique, IBMC, UPR 9021 CNRS, Strasbourg, France
    J Pept Sci 7:208-19. 2001
  9. ncbi N-hydroxy peptides as substrates for alpha-chymotrypsin
    A Bianco
    Institut fur Organische Chemie, Universitat Tubingen, Germany
    J Pept Res 54:544-8. 1999
  10. ncbi C3-symmetric peptide scaffolds are functional mimetics of trimeric CD40L
    Sylvie Fournel
    UPR 9021 CNRS, Immunologie et Chimie Thérapeutiques, Institut de Biologie Moleculaire et Cellulaire, 15 rue Rene Descartes, F 67084 Strasbourg, France
    Nat Chem Biol 1:377-82. 2005

Collaborators

Detail Information

Publications45

  1. ncbi Carbon-nanotube shape and individualization critical for renal excretion
    Lara Lacerda
    Nanomedicine Laboratory, Centre for Drug Delivery Research The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N1AX, UK
    Small 4:1130-2. 2008
  2. ncbi Solid-phase synthesis and characterization of a novel fullerene-peptide derived from histone H3
    Alberto Bianco
    Institute of Molecular and Cellular Biology, UPR 9021 CNRS, 67084 Strasbourg, France
    Org Biomol Chem 1:4141-3. 2003
    ..By molecular modelling it was verified that this peptide derivative is able to retain a binding capacity to the MHC (major histocompatibility complex) molecule similar to that of the cognate epitope...
  3. ncbi Carbon nanotubes: on the road to deliver
    Alberto Bianco
    UPR 9021, CNRS, Institut de Biologie Moleculaire et Cellulaire, 15 rue Rene Descartes, F 67084, Strasbourg, France
    Curr Drug Deliv 2:253-9. 2005
    ..This opens new therapeutic and preventive opportunities to combat diseases. The scope of this review is to summarize our recent work in this rapidly growing field...
  4. ncbi Cationic carbon nanotubes bind to CpG oligodeoxynucleotides and enhance their immunostimulatory properties
    Alberto Bianco
    Institut de Biologie Moleculaire et Cellulaire, UPR9021 CNRS, Immunologie et Chimie Thérapeutiques, 67084 Strasbourg, France
    J Am Chem Soc 127:58-9. 2005
    ..Functionalized cationic carbon nanotubes are able to form a stable complex with CpG ODN based on charge interaction and to increase the immunostimulatory activity of CpG motifs...
  5. ncbi Solid-phase synthesis of CD40L mimetics
    Alberto Bianco
    Institut de Biologie Moleculaire et Cellulaire, UPR 9021 CNRS, Immunologie et Chimie Thérapeutiques, 15 rue Rene Descartes, 67084 Strasbourg, France
    Org Biomol Chem 4:1461-3. 2006
    ..The present report describes a general solid-phase synthesis approach to and related trimeric architectures. In addition, their CD40 binding properties as well as their effector functions have been evaluated...
  6. ncbi Carbon nanotubes for the delivery of therapeutic molecules
    Alberto Bianco
    Institut de Biologie Moleculaire et Cellulaire, UPR 9021, CNRS, Immunologie et Chimie Thérapeutiques, 15 rue Rene Descartes, 67084 Strasbourg Cedex, France
    Expert Opin Drug Deliv 1:57-65. 2004
    ..Research discussed in this review is focused on recent advances in the development of CNT technology for the delivery of drugs, antigens and genes...
  7. ncbi Opportunities and challenges of carbon-based nanomaterials for cancer therapy
    Alberto Bianco
    CNRS, Institut de Biologie Moleculaire et Cellulaire, UPR 9021 Immonulogie et Chimie Thérapeutiques, 67000 Strasbourg, France
    Expert Opin Drug Deliv 5:331-42. 2008
    ..A comparison between the characteristics, the advantages, the drawbacks, the benefits and the risks associated with these novel biocompatible forms of carbon is presented here...
  8. ncbi Fullerene-based amino acids and peptides
    A Bianco
    Laboratoire de Chimie Immunologique, IBMC, UPR 9021 CNRS, Strasbourg, France
    J Pept Sci 7:208-19. 2001
    ..In this review, we will discuss our own achievements in this rapidly growing field. In particular, the application of fulleroproline (Fpr) amino acids and peptides to medicinal chemistry and material science will be highlighted...
  9. ncbi N-hydroxy peptides as substrates for alpha-chymotrypsin
    A Bianco
    Institut fur Organische Chemie, Universitat Tubingen, Germany
    J Pept Res 54:544-8. 1999
    ..This property of the hydroxamate group may be of particular advantage for the introduction of a specific cleavage site within peptidomimetics or in prodrugs...
  10. ncbi C3-symmetric peptide scaffolds are functional mimetics of trimeric CD40L
    Sylvie Fournel
    UPR 9021 CNRS, Immunologie et Chimie Thérapeutiques, Institut de Biologie Moleculaire et Cellulaire, 15 rue Rene Descartes, F 67084 Strasbourg, France
    Nat Chem Biol 1:377-82. 2005
    ..Architectures based on rigid C3-symmetric cores may thus represent a general approach to mimicking homotrimers of the TNF superfamily...
  11. ncbi Functionalized carbon nanotubes as emerging nanovectors for the delivery of therapeutics
    Cedric Klumpp
    Institute of Molecular and Cellular Biology, UPR 9021 CNRS, 15 rue Rene Descartes, 67084 Strasbourg, France
    Biochim Biophys Acta 1758:404-12. 2006
    ..Once the cargos are carried into various cells, tissues and organs they are able to express their biological function. In this review, we will describe the potential of f-CNT to deliver different types of therapeutic molecules...
  12. ncbi Synthesis, structural characterization, and immunological properties of carbon nanotubes functionalized with peptides
    Davide Pantarotto
    Institute of Molecular and Cellular Biology, UPR 9021 CNRS, 67084 Strasbourg, France
    J Am Chem Soc 125:6160-4. 2003
    ..In addition, this peptide-NT conjugate is immunogenic, eliciting antibody responses of the right specificity. Such a system could be greatly advantageous for diagnostic purposes and could find future applications in vaccine delivery...
  13. ncbi Targeted delivery of amphotericin B to cells by using functionalized carbon nanotubes
    Wei Wu
    , UPR9021 CNRS, , 67084 Strasbourg, France
    Angew Chem Int Ed Engl 44:6358-62. 2005
  14. ncbi Immunization with peptide-functionalized carbon nanotubes enhances virus-specific neutralizing antibody responses
    Davide Pantarotto
    , UPR 9021 CNRS, , , 67084 Strasbourg, France
    Chem Biol 10:961-6. 2003
  15. ncbi Immunomodulatory consequences of ODN CpG-polycation complexes
    Charalambos D Partidos
    CNRS UPR 9021, Institut de Biologie Moleculaire et Cellulaire, Strasbourg, France
    Methods 49:328-33. 2009
    ..Overall, our findings together with published data support the view that for harnessing the beneficial effects of ODN CpGs a careful consideration has to be given depending on the target intervention...
  16. ncbi Synthesis and characterization of nucleobase-carbon nanotube hybrids
    Prabhpreet Singh
    CNRS, Institut de Biologie Moleculaire et Cellulaire, Laboratoire d Immunologie et Chimie Thérapeutiques, 67000 Strasbourg, France
    J Am Chem Soc 131:13555-62. 2009
    ....
  17. ncbi Functionalized carbon nanotubes are non-cytotoxic and preserve the functionality of primary immune cells
    Hélène Dumortier
    CNRS UPR 9021, Institute of Molecular and Cellular Biology, Strasbourg, France
    Nano Lett 6:1522-8. 2006
    ..f-CNT 3, which instead possesses reduced solubility and forms mainly stable water suspensions, preserved lymphocytes' functionality while provoking secretion of proinflammatory cytokines by macrophages...
  18. ncbi Design and activity of cationic fullerene derivatives as inhibitors of acetylcholinesterase
    Giorgia Pastorin
    Institute of Molecular and Cellular Biology, UPR 9021 CNRS, Strasbourg, France
    Org Biomol Chem 4:2556-62. 2006
    ..The cationic C(60) derivatives used in this study represent a new class of molecules potentially able to modulate the enzymatic activity of acetylcholinesterase...
  19. ncbi Enhanced anticancer activity of multi-walled carbon nanotube-methotrexate conjugates using cleavable linkers
    Cristian Samorì
    CNRS, Institut de Biologie Moleculaire et Cellulaire, Laboratoire d Immunologie et Chimie Thérapeutiques, 67000 Strasbourg, France
    Chem Commun (Camb) 46:1494-6. 2010
    ..The new nanobio-hybrid conjugates were internalized into human breast cancer cells and it was shown that the cytotoxic activity was strongly dependent on the presence and type of linker...
  20. ncbi Applications of carbon nanotubes in drug delivery
    Alberto Bianco
    Institute of Molecular and Cellular Biology, UPR 9021 CNRS, 67084 Strasbourg, France
    Curr Opin Chem Biol 9:674-9. 2005
    ..Because functionalised CNT display low toxicity and are not immunogenic, such systems hold great potential in the field of nanobiotechnology and nanomedicine...
  21. ncbi Characterization of the 310-helix in model peptides by HRMAS NMR spectroscopy
    Nathalie Lancelot
    Institute of Chemistry, FRE 2446 CNRS-Bruker, , 67084 Strasbourg, France
    Chemistry 9:1317-23. 2003
    ....
  22. ncbi Organic functionalisation and characterisation of single-walled carbon nanotubes
    Prabhpreet Singh
    CNRS, Institut de Biologie Moleculaire et Cellulaire, Laboratoire d Immunologie et Chimie Thérapeutiques, 15 rue Rene Descartes, 67000, Strasbourg, France
    Chem Soc Rev 38:2214-30. 2009
    ..In this tutorial review, we survey the covalent modification of SWCNTs with organic moieties, and illustrate the major analytical techniques routinely used to characterise the functionalised materials...
  23. ncbi Proton dipolar recoupling in resin-bound peptides under high-resolution magic angle spinning
    Jesus Raya
    Institut de Chimie, UMR 7510 CNRS Bruker, Universite Louis Pasteur, Strasbourg, France
    J Magn Reson 157:43-51. 2002
    ..In addition, it is found that during the relatively long mixing times required to transfer magnetization in such soft materials, the RFDR sequence also achieves magnetization transfer via the scalar J-coupling...
  24. ncbi Design and synthesis of intrinsically cell-penetrating nucleopeptides
    Piero Geotti-Bianchini
    CNRS, Institut de Biologie Moleculaire et Cellulaire, Laboratoire d Immunologie et Chimie Thérapeutiques, 15 rue Rene Descartes, 67000, Strasbourg, France
    Org Biomol Chem 6:3661-3. 2008
    ..Nucleopeptides, which are constituted of alpha-amino acids bearing nucleobases at their side chains, are able to penetrate into cells and to reach the nucleus without cytotoxic effects...
  25. ncbi Exploring helical folding of oligoureas during chain elongation by high-resolution magic-angle-spinning (HRMAS) NMR spectroscopy
    Aude Violette
    CNRS, Institut de Biologie Moleculaire et Cellulaire, Immunologie et Chimie Thérapeutiques, 15 rue Descartes, 67084 Strasbourg, France
    Chemistry 14:3874-82. 2008
    ..On-bead NOESY spectra of high quality and with resolution comparable to that of liquid samples were obtained for longer oligomers, thus allowing detailed structural characterization...
  26. ncbi Functionalized carbon nanotubes for probing and modulating molecular functions
    Cécilia Ménard-Moyon
    Centre National de la Recherche Scientifique, Institut de Biologie Moleculaire et Cellulaire, UPR 9021 Immunologie et Chimie Thérapeutiques, 67000 Strasbourg, France
    Chem Biol 17:107-15. 2010
    ....
  27. ncbi Functionalized carbon nanotubes in drug design and discovery
    Maurizio Prato
    Dipartimento di Scienze Farmaceutiche, Universita di Trieste, 34127 Trieste, Italy
    Acc Chem Res 41:60-8. 2008
    ....
  28. ncbi Tissue biodistribution and blood clearance rates of intravenously administered carbon nanotube radiotracers
    Ravi Singh
    Centre for Drug Delivery Research, School of Pharmacy, University of London, UK
    Proc Natl Acad Sci U S A 103:3357-62. 2006
    ..This work describes the pharmacokinetic parameters of i.v. administered functionalized CNT relevant for various therapeutic and diagnostic applications...
  29. ncbi A helical peptide receptor for [60]fullerene
    Alberto Bianco
    , 35131 Padova, Italy
    Chemistry 8:1544-53. 2002
    ..Further evidence for this superstructure has been provided in the gas phase by a mass spectrometric investigation...
  30. ncbi Cutting edge: small molecule CD40 ligand mimetics promote control of parasitemia and enhance T cells producing IFN-gamma during experimental Trypanosoma cruzi infection
    Mohammed Habib
    Laboratoire d Immunologie Expérimentale, Universite Libre de Bruxelles, Brussels, Belgium
    J Immunol 178:6700-4. 2007
    ..Our results indicate that CD40L mimetics are effective in vivo and promote the control of T. cruzi infection by overcoming the immunosuppression usually induced by the parasites...
  31. ncbi Synthesis and biological properties of fullerene-containing amino acids and peptides
    Davide Pantarotto
    Dipartimento di Scienze Farmaceutiche, , Italy
    Mini Rev Med Chem 4:805-14. 2004
    ..Finally, applications in medicinal chemistry of such types of amino acids and peptides will be highlighted...
  32. ncbi Binding and condensation of plasmid DNA onto functionalized carbon nanotubes: toward the construction of nanotube-based gene delivery vectors
    Ravi Singh
    Centre for Drug Delivery Research and Electron Microscopy Unit, The School of Pharmacy, University of London, London WC1N 1AX, United Kingdom
    J Am Chem Soc 127:4388-96. 2005
    ..This study constitutes the first thorough investigation into the physicochemical interactions between cationic functionalized carbon nanotubes and DNA toward construction of carbon nanotube-based gene transfer vector systems...
  33. ncbi Functionalized carbon nanotubes for plasmid DNA gene delivery
    Davide Pantarotto
    Dipartimento di Scienze Farmaceutiche, , 34127 Trieste, Italy
    Angew Chem Int Ed Engl 43:5242-6. 2004
  34. ncbi Solid-phase synthesis of fullerene-peptides
    Davide Pantarotto
    Department of Pharmaceutical Sciences, University of Trieste, Piazzale Europa 1, 34127 Trieste, Italy
    J Am Chem Soc 124:12543-9. 2002
    ..aureus and also lysed erythrocytes. The availability of a fullero-amino acid easily useable in the SPPS of fullero-peptides may thus open the way to the synthesis of new types of biologically active oligomers...
  35. ncbi The anti-HIV pentameric pseudopeptide HB-19 binds the C-terminal end of nucleolin and prevents anchorage of virus particles in the plasma membrane of target cells
    Sebastien Nisole
    Unité de Virologie et Immunologie Cellulaire URA 1930 CNRS, Plateau Technique, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Biol Chem 277:20877-86. 2002
    ....
  36. ncbi Cellular uptake of functionalized carbon nanotubes is independent of functional group and cell type
    Kostas Kostarelos
    Nat Nanotechnol 2:108-13. 2007
  37. ncbi Covalent assembly and micropatterning of functionalized multiwalled carbon nanotubes to monolayer-modified Si(111) surfaces
    Bruno Fabre
    Université de Rennes 1 and CNRS UMR 6226 Sciences Chimiques de Rennes, Matiere Condensee et Systemes Electroactifs MaCSE, Campus de Beaulieu, 35042 Rennes Cedex, France
    Langmuir 24:6595-602. 2008
    ..In particular, it is demonstrated that the MWNT patterns allow a faster charge transfer which is consistent with the results obtained for the uniformly modified surfaces...
  38. ncbi Hype around nanotubes creates unrealistic hopes
    Kostas Kostarelos
    Nature 453:280. 2008
  39. ncbi DEUSS: a perdeuterated poly(oxyethylene)-based resin for improving HRMAS NMR studies of solid-supported molecules
    Alexander Poschalko
    Vienna University of Technology, Institute of Applied Synthetic Chemistry, 1060 Vienna, Austria
    Chemistry 10:4532-7. 2004
    ....
  40. ncbi Tissue histology and physiology following intravenous administration of different types of functionalized multiwalled carbon nanotubes
    Lara Lacerda
    The School of Pharmacy, University of London, Nanomedicine Laboratory, Centre for Drug Delivery Research, London WC1N 1AX, UK
    Nanomedicine (Lond) 3:149-61. 2008
    ..The administration of CNTs may, however, impact the physiological function of organs through which CNTs traverse or accumulate...
  41. ncbi [60]fullerene-pyrrolidine-N-oxides
    Peter Brough
    Dipartimento di Scienze Farmaceutiche, , 34127 Trieste, Italy
    J Org Chem 71:2014-20. 2006
    ..Preliminary details of the effects of substitution on the reactivity of the pyrrolidine ring are also reported...
  42. ncbi Chemistry of carbon nanotubes
    Dimitrios Tasis
    Department of Materials Science, University of Patras, 26504 Rio Patras, Greece
    Chem Rev 106:1105-36. 2006
  43. ncbi Carbon nanotubes as nanomedicines: from toxicology to pharmacology
    Lara Lacerda
    Nanomedicine Laboratory, Centre for Drug Delivery Research, The School of Pharmacy, University of London 29-39 Brunswick Square WC1N 1AX, United Kingdom
    Adv Drug Deliv Rev 58:1460-70. 2006
    ....
  44. ncbi SUBPOL: a novel SUcrose-Based Polymer support for solid-phase peptide synthesis and affinity chromatography applications
    Alexander Poschalko
    Vienna University of Technology, Institute of Applied Synthetic Chemistry, Division of Macromolecular Chemistry, Getreidemarkt 9 163 MC, 1060 Vienna, Austria
    J Am Chem Soc 125:13415-26. 2003
    ..A specific affinity adsorbent containing the fibrinogen-binding pentapeptide GPRPK was prepared by SPPS on SUBPOL resins of different morphology, and the strong impact of the affinity matrix on adsorption performance was demonstrated...
  45. ncbi Peptides in nanotechnology. Introduction
    Alberto Bianco
    J Pept Sci 14:117. 2008