Michel Beylot

Summary

Country: France

Publications

  1. ncbi request reprint In vivo studies of intrahepatic metabolic pathways
    M Beylot
    Laboratoire de Physiopathologie Métabotique et Rénale, Faculté de Médecine R Laennec, Lyon, France
    Diabetes Metab 23:251-7. 1997
  2. ncbi request reprint Effects of inulin-type fructans on lipid metabolism in man and in animal models
    Michel Beylot
    INSERM U 499, Faculté RTH Laennec, Lyon, France
    Br J Nutr 93:S163-8. 2005
  3. pmc Lipogenesis in arterial wall and vascular smooth muscular cells: regulation and abnormalities in insulin-resistance
    Nadjiba Hamlat
    ERI 22 EA4173, Faculté Rockefeller, UCBLyon1, Lyon, France
    Cardiovasc Diabetol 8:64. 2009
  4. ncbi request reprint Comparison of the expression and activity of the lipogenic pathway in human and rat adipose tissue
    Dominique Letexier
    INSERM U 499, Faculté RTH Laennec, 69008 Lyon, France
    J Lipid Res 44:2127-34. 2003
  5. ncbi request reprint Differences in the regulation of adipose tissue and liver lipogenesis by carbohydrates in humans
    Frederique Diraison
    INSERM U 499 and GENALYS, Faculté RTH Laennec, 69008, Lyon, France
    J Lipid Res 44:846-53. 2003
  6. ncbi request reprint Long-term administration of inulin-type fructans has no significant lipid-lowering effect in normolipidemic humans
    Fabien Forcheron
    INSERM U 499, Faculté RTH Laennec, IFR 62, Universite Claude Bernard Lyon, 69008 Lyon, France
    Metabolism 56:1093-8. 2007
  7. pmc Diabetic cardiomyopathy: effects of fenofibrate and metformin in an experimental model--the Zucker diabetic rat
    Fabien Forcheron
    EA4173 ERI22 Agressions vasculaires et réponses tissulaires Faculté Rockefeller, UCBLyon1 and INSERM, Lyon, France
    Cardiovasc Diabetol 8:16. 2009
  8. ncbi request reprint Addition of inulin to a moderately high-carbohydrate diet reduces hepatic lipogenesis and plasma triacylglycerol concentrations in humans
    Dominique Letexier
    INSERM U 499, Faculté RTH Laennec, Lyon, France
    Am J Clin Nutr 77:559-64. 2003
  9. doi request reprint Nonalcoholic hepatic steatosis in Zucker diabetic rats: spontaneous evolution and effects of metformin and fenofibrate
    Fabien Forcheron
    INSERM ERI 22 EA 4173, Faculté Rockefeller, Lyon, France
    Obesity (Silver Spring) 17:1381-9. 2009
  10. pmc Increased atherosclerosis in mice deficient in perilipin1
    Dominique Langlois
    ERI22 EA4173, Faculté Rockefeller, University C Bernard Lyon1, 8 av Rockefeller, Lyon, 69008, France
    Lipids Health Dis 10:169. 2011

Collaborators

  • Fabien Forcheron
  • Liliana Legedz
  • Catherine Cerutti
  • V Large
  • Cécile Chambrier
  • Dominique Langin
  • P Arner
  • Frederique Diraison
  • Dominique Letexier
  • Peggy Del Carmine
  • Giampiero Bricca
  • Dominique Langlois
  • Nadjiba Hamlat
  • Eric Dusserre
  • Coralie Metais
  • Patrick Feugier
  • Pauline Abdallah
  • Alexandra Basset
  • Emmanuelle Belloto
  • Wassim Hodroj
  • Ana Cachefo
  • Hind Ray
  • Samia Neggazi
  • Jacques Yuan Li
  • Souhila Aouichat-Bouguerra
  • Samia Negazzi
  • Nabil Foudi
  • Marie Claude Bourdillon
  • Gwenola Allain
  • Jacques Randon
  • Vincent Frering
  • Philippe Boucher
  • Claudie Pinteur
  • Cecilia Holm
  • Paul Bouletreau
  • Peter Jones
  • Vivienne Yankah
  • Dominique Larrouy
  • Monique Sothier
  • Hubert Vidal

Detail Information

Publications20

  1. ncbi request reprint In vivo studies of intrahepatic metabolic pathways
    M Beylot
    Laboratoire de Physiopathologie Métabotique et Rénale, Faculté de Médecine R Laennec, Lyon, France
    Diabetes Metab 23:251-7. 1997
    ..All these non-invasive techniques allow investigations to be undertaken in human beings to study the nutritional and hormonal regulation of liver metabolism in normal subjects and in pathological situations...
  2. ncbi request reprint Effects of inulin-type fructans on lipid metabolism in man and in animal models
    Michel Beylot
    INSERM U 499, Faculté RTH Laennec, Lyon, France
    Br J Nutr 93:S163-8. 2005
    ..The effects on plasma cholesterol appear also more marked in hyperlipidaemic subjects than in healthy controls, suggesting that inulin and oligofructose have beneficial effects in these types of subjects...
  3. pmc Lipogenesis in arterial wall and vascular smooth muscular cells: regulation and abnormalities in insulin-resistance
    Nadjiba Hamlat
    ERI 22 EA4173, Faculté Rockefeller, UCBLyon1, Lyon, France
    Cardiovasc Diabetol 8:64. 2009
    ..Therefore in situ lipogenesis could provide fatty acids for triglycerides synthesis and cholesterol esterification and contribute to lipid accumulation in arterial wall with aging and during atheroma...
  4. ncbi request reprint Comparison of the expression and activity of the lipogenic pathway in human and rat adipose tissue
    Dominique Letexier
    INSERM U 499, Faculté RTH Laennec, 69008 Lyon, France
    J Lipid Res 44:2127-34. 2003
    ..This is not related to differences in diet and is probably explained by lower abundance of SREBP-1c protein. A decreased expression of ChREBP could also play a role...
  5. ncbi request reprint Differences in the regulation of adipose tissue and liver lipogenesis by carbohydrates in humans
    Frederique Diraison
    INSERM U 499 and GENALYS, Faculté RTH Laennec, 69008, Lyon, France
    J Lipid Res 44:846-53. 2003
    ..mRNA levels were not increased by the HC diet. Adipose DNL is active in humans, but contributes little to TAG stores and is less responsive than liver DNL to stimulation by carbohydrates...
  6. ncbi request reprint Long-term administration of inulin-type fructans has no significant lipid-lowering effect in normolipidemic humans
    Fabien Forcheron
    INSERM U 499, Faculté RTH Laennec, IFR 62, Universite Claude Bernard Lyon, 69008 Lyon, France
    Metabolism 56:1093-8. 2007
    ..In conclusion, contrary to what was observed in short-term studies, we observed no significant beneficial effect of a long-term (6-month) administration of inulin-type fructans on plasma lipids in healthy human subjects...
  7. pmc Diabetic cardiomyopathy: effects of fenofibrate and metformin in an experimental model--the Zucker diabetic rat
    Fabien Forcheron
    EA4173 ERI22 Agressions vasculaires et réponses tissulaires Faculté Rockefeller, UCBLyon1 and INSERM, Lyon, France
    Cardiovasc Diabetol 8:16. 2009
    ..We evaluated the possible usefulness of two molecules promoting lipid oxidation, fenofibrate and metformin, in an experimental model of DCM, the Zucker diabetic rat (ZDF)...
  8. ncbi request reprint Addition of inulin to a moderately high-carbohydrate diet reduces hepatic lipogenesis and plasma triacylglycerol concentrations in humans
    Dominique Letexier
    INSERM U 499, Faculté RTH Laennec, Lyon, France
    Am J Clin Nutr 77:559-64. 2003
    ..However, such a diet can increase plasma triacylglycerol concentrations--an undesirable side effect. The addition of nondigestible carbohydrate could reduce the risk of elevated triacylglycerol concentrations...
  9. doi request reprint Nonalcoholic hepatic steatosis in Zucker diabetic rats: spontaneous evolution and effects of metformin and fenofibrate
    Fabien Forcheron
    INSERM ERI 22 EA 4173, Faculté Rockefeller, Lyon, France
    Obesity (Silver Spring) 17:1381-9. 2009
    ..To conclude, metformin had only moderate effects on liver steatosis. The effects of fenofibrate was more marked but remained mild...
  10. pmc Increased atherosclerosis in mice deficient in perilipin1
    Dominique Langlois
    ERI22 EA4173, Faculté Rockefeller, University C Bernard Lyon1, 8 av Rockefeller, Lyon, 69008, France
    Lipids Health Dis 10:169. 2011
    ..The aim of the study was to investigate this possible role of perilipin1 in atherogenesis...
  11. ncbi request reprint Genes of cholesterol metabolism in human atheroma: overexpression of perilipin and genes promoting cholesterol storage and repression of ABCA1 expression
    Fabien Forcheron
    INSERM U499, Faculte Laennec, UCB Lyon I, Lyon, France
    Arterioscler Thromb Vasc Biol 25:1711-7. 2005
    ..It may also depend on proteins surrounding lipid droplets, adipophilin, and perilipins. They favor triglyceride storage in adipocytes and could play a similar role for cholesterol in atheroma...
  12. ncbi request reprint Mechanisms of the triglyceride- and cholesterol-lowering effect of fenofibrate in hyperlipidemic type 2 diabetic patients
    Fabien Forcheron
    INSERM U 499, Faculté RTH Laennec, Rue G Paradin, 69008 Lyon, France
    Diabetes 51:3486-91. 2002
    ....
  13. ncbi request reprint Increased insulin-stimulated expression of arterial angiotensinogen and angiotensin type 1 receptor in patients with type 2 diabetes mellitus and atheroma
    Wassim Hodroj
    EA 3740, Functional Genomics in Atherothrombosis, Universite de Lyon, Lyon, France
    Arterioscler Thromb Vasc Biol 27:525-31. 2007
    ..Because inhibition of the renin-angiotensin system (RAS) reduces the onset of type 2 diabetes (T2D) and prevents atherosclerosis, we investigated the expression of RAS in the arterial wall of T2D and nondiabetic (CTR) patients...
  14. ncbi request reprint Stimulation of cholesterol synthesis and hepatic lipogenesis in patients with severe malabsorption
    Ana Cachefo
    INSERM U499, Faculte Laennec, Lyon, France
    J Lipid Res 44:1349-54. 2003
    ..Severe malabsorption induces large increases of cholesterol synthesis and hepatic lipogenesis independently of the presence of parenteral nutrition. These abnormalities are probably due to the malabsorption of bile acids...
  15. ncbi request reprint Expression of the adiponectin receptors AdipoR1 and AdipoR2 in lean rats and in obese Zucker rats
    Michel Beylot
    INSERM U499, Metabolic and Renal Physiolopathology, Faculté RTH Laennec, 69008 Lyon, France
    Metabolism 55:396-401. 2006
    ..These results do not support an important role for the expression of AdipoR1 and AdipoR2 in the modulation of sensitivity to insulin...
  16. ncbi request reprint Increased hepatic lipogenesis but decreased expression of lipogenic gene in adipose tissue in human obesity
    Frederique Diraison
    Institut National de la Santé et de la Recherche Médicale Unité 499, Faculté RTH Laennec, 69008 Lyon, France
    Am J Physiol Endocrinol Metab 282:E46-51. 2002
    ..In conclusion, subjects with established obesity have an increased hepatic lipogenesis that could contribute to their excessive fat mass but no evidence for an increased lipogenic capacity of adipose tissue...
  17. ncbi request reprint Use of stable isotopes to evaluate the functional effects of nutrients
    Michel Beylot
    INSERM U499, Faculté RTH Laennec, Lyon, France
    Curr Opin Clin Nutr Metab Care 9:734-9. 2006
    ..This review presents recent advances in the use of stable isotopes to investigate how nutrients can influence pathways of glucose, lipids and protein metabolism, and also intestinal absorption, body composition and fat mass turnover...
  18. ncbi request reprint The presence of a catalytically inactive form of hormone-sensitive lipase is associated with decreased lipolysis in abdominal subcutaneous adipose tissue of obese subjects
    Hind Ray
    Institut National de la Santé et de la Recherche Medicale INSERM 499, Faculte de Medecine Laennec, Rue Paradin, 69372 Lyon, France
    Diabetes 52:1417-22. 2003
    ..05). These results suggest that the presence of the truncated HSL protein is associated with an impaired adipocyte lipolysis...
  19. ncbi request reprint Determination of protein replacement rates by deuterated water: validation of underlying assumptions
    Emmanuelle Belloto
    1Institut National de la Santé et de la Recherche Médicale U499, Faculté Réne Theodore Hyacinthe, Laennec, France
    Am J Physiol Endocrinol Metab 292:E1340-7. 2007
    ..All of these results support (2)H(2)O as a safe, reliable, useful, and convenient tracer for studies of protein synthesis, including proteins with slow turnover rate...
  20. doi request reprint Adiponectin receptors: expression in Zucker diabetic rats and effects of fenofibrate and metformin
    Coralie Metais
    EA 4173 ERI 22 agressions vasculaires et réponses tissulaires, Faculté Rockefeller, UCBLyon1, 69008 Lyon, France
    Metabolism 57:946-53. 2008
    ..Parts of the actions of fenofibrate and of metformin could be mediated by a stimulation of the expression of these receptors in liver and in insulin-sensitive, glucose-utilizing tissues (muscle, WAT), respectively...