Research Topics
Genomes and Genes
| Serge BenichouSummaryCountry: France Publications
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Detail Information
Publications
[The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: "parasites"of the endocytosis pathway]Serge Benichou
Departement de Maladies Infectieuses, INSERM U 567, CNRS UMR 8104, Institut Cochin, bâtiment Gustave Roussy, 27, rue du Faubourg Saint Jacques, 75014 Paris, France
Med Sci (Paris) 19:100-6. 2003..In addition, these viral factors represent valuable tools to study the pathway they are perturbing...- Dynamic interaction of HIV-1 Nef with the clathrin-mediated endocytic pathway at the plasma membraneAnne Burtey
Institut Cochin, Département Maladies Infectieuses, Paris F 75014, France
Traffic 8:61-76. 2007.... - Nef-induced alteration of the early/recycling endosomal compartment correlates with enhancement of HIV-1 infectivityRicardo Madrid
Institut Cochin, Department of Infectious Diseases, INSERM U567, CNRS UMR8104, Universite Paris 5, 75014 Paris, France
J Biol Chem 280:5032-44. 2005.... - The Siva protein is a novel intracellular ligand of the CD4 receptor that promotes HIV-1 envelope-induced apoptosis in T-lymphoid cellsBénédicte Py
Institut Cochin, CNRS UMR 8104, Universite Paris Descartes, 27 rue du Faubourg Saint Jacques, 75014, Paris, France
Apoptosis 12:1879-92. 2007..Altogether, these results suggest that Siva-1 might participate in the CD4-initiated signaling apoptotic pathway induced by the HIV-1 envelope in T-lymphoid cells... - Single-domain antibody-SH3 fusions for efficient neutralization of HIV-1 Nef functionsJerome Bouchet
Institut Cochin, CNRS UMR8104, Universite Paris Descartes, Paris, France
J Virol 86:4856-67. 2012..These results demonstrate that it is possible to inhibit all functions of Nef, both in T lymphocytes and macrophages, with a single ligand that represents an efficient tool to develop new antiviral strategies targeting Nef... - Nef-induced CD4 endocytosis in human immunodeficiency virus type 1 host cells: role of p56lck kinaseNadine Laguette
Institut Cochin, CNRS UMR 8104, Universite Paris Descartes, Paris, France
J Virol 83:7117-28. 2009..Our results imply that Nef uses distinct mechanisms to downregulate the cell surface expression levels of CD4 in either lymphoid or myeloid target cells of HIV-1... - The phospholipid scramblases 1 and 4 are cellular receptors for the secretory leukocyte protease inhibitor and interact with CD4 at the plasma membraneBénédicte Py
Institut Cochin, Universite Paris Descartes, CNRS, UMR 8104, Paris, France
PLoS ONE 4:e5006. 2009..These interactions may constitute new targets for antiviral intervention... - Inhibition of phagocytosis in HIV-1-infected macrophages relies on Nef-dependent alteration of focal delivery of recycling compartmentsJulie Mazzolini
Institut Cochin, Universite Paris Descartes, Centre National de la Recherche Scientifique Unite Mixte de Recherche 8104, Paris, France
Blood 115:4226-36. 2010..We conclude that HIV-1 impairs optimal phagosome formation through Nef-dependent perturbation of the endosomal remodeling relying on AP1. We therefore identified a mechanism of macrophage function down-regulation in infected cells... - HIV-1 Nef stabilizes the association of adaptor protein complexes with membranesKaty Janvier
Institut Cochin, Department of Infectious Diseases, INSERM U567 CNRS UMR8104, Universite Paris V, 24 rue du Faubourg Saint Jacques, France
J Biol Chem 278:8725-32. 2003..The stabilization of these complexes on membranes may underlie the pleiotropic effects of Nef on protein trafficking within the endosomal system... - Human immunodeficiency virus type 1 Vpr modulates cellular expression of UNG2 via a negative transcriptional effectChristelle Langevin
Institut Cochin, CNRS UMR 8104, Universite Paris Descartes, Paris, France
J Virol 83:10256-63. 2009..Finally, we show that Vpr influences the UNG2 promoter without affecting UNG1 gene expression. These data indicate that the Vpr-induced decrease of UNG2 level is mainly related to a transcriptional effect... - Recruitment of the nuclear form of uracil DNA glycosylase into virus particles participates in the full infectivity of HIV-1Carolin A Guenzel
INSERM, U1016, Institut Cochin, Paris, France
J Virol 86:2533-44. 2012.... - Localization of HIV-1 Vpr to the nuclear envelope: impact on Vpr functions and virus replication in macrophagesGuillaume Jacquot
Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
Retrovirology 4:84. 2007..In the present study, we have explored the contribution of Vpr accumulation at the NE to the Vpr functions, including G2-arrest and pro-apoptotic activities, and virus replication in primary macrophages... - Docking of HIV-1 Vpr to the nuclear envelope is mediated by the interaction with the nucleoporin hCG1Erwann Le Rouzic
Institut Cochin, Department of Infectious Diseases, CNRS UMR8104, INSERM U567, , Paris, France
J Biol Chem 277:45091-8. 2002..This association of Vpr with a component of the nuclear pore complex may contribute to the disruption of the nuclear envelope and to the nuclear import of the viral DNA... - Inhibition of the Nef regulatory protein of HIV-1 by a single-domain antibodyJerome Bouchet
Institut Cochin, CNRS UMR8104, Universite Paris Descartes, 27 rue du Faubourg Saint Jacques, Paris, France
Blood 117:3559-68. 2011.... - Characterization of the molecular determinants of primary HIV-1 Vpr proteins: impact of the Q65R and R77Q substitutions on Vpr functionsGuillaume Jacquot
Institut Cochin, Universite Paris Descartes, CNRS, UMR 8104, Paris, France
PLoS ONE 4:e7514. 2009..In contradiction with published results, the R77Q substitution, found in LTNP alleles, did not influence Vpr proapoptotic activity... - Human immunodeficiency virus type 1 Nef incorporation into virions does not increase infectivityNadine Laguette
Institut Cochin, CNRS UMR8104, Universite Paris Descartes, Paris, France
J Virol 83:1093-104. 2009..These findings demonstrate that the presence of Nef in viral particles is not sufficient to increase human immunodeficiency virus type 1 infectivity and suggest that Nef plays a role during the biogenesis of viral particles... - Oligomerization of the diaphanous-related formin FHOD1 requires a coiled-coil motif critical for its cytoskeletal and transcriptional activitiesRicardo Madrid
Department of Infectious Diseases, Institut Cochin, INSERM U567, CNRS UMR 8104, Universite Paris V, 27 rue du Faubourg Saint Jacques, 75014 Paris, France
FEBS Lett 579:441-8. 2005..Together, these results indicate that oligomerization of FHOD1 via the coiled-coil motif is a critical parameter for its biological activities... - Human immunodeficiency virus (HIV) type-1, HIV-2 and simian immunodeficiency virus Nef proteinsNadine Laguette
Institut Cochin, CNRS UMR8104, Universite Paris Descartes, Paris, France
Mol Aspects Med 31:418-33. 2010..This review summarizes common and distinct features among Nef proteins and how they contribute to increasing HIV and SIV fitness towards their respective hosts... - Molecular and functional basis for the scaffolding role of the p50/dynamitin subunit of the microtubule-associated dynactin complexGuillaume Jacquot
Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
J Biol Chem 285:23019-31. 2010..Interestingly, p50/DM self-association does not contribute to p50/DM-induced disruption of the dynactin complex, but most likely participates in the stabilization of the complex... - Differential nucleocytoplasmic shuttling of beta-arrestins. Characterization of a leucine-rich nuclear export signal in beta-arrestin2Mark G H Scott
Department of Cell Biology, Institut Cochin, Pavillon Gustave Roussy, 75679 Paris Cedex 14, France
J Biol Chem 277:37693-701. 2002..These data indicate that the nucleocytoplasmic shuttling of betaarr2 controls the subcellular distribution of JNK3... - Human Dlg protein binds to the envelope glycoproteins of human T-cell leukemia virus type 1 and regulates envelope mediated cell-cell fusion in T lymphocytesVincent Blot
Département Biologie Cellulaire, CNRS UMR 8104 and INSERM U567, Institut Cochin, 22 rue Mechain, 75014 Paris, France
J Cell Sci 117:3983-93. 2004..We thus propose that hDlg stabilizes HTLV-1 envelope glycoproteins at the virological synapse formed between infected and target cells, hence assisting the cell-to-cell transmission of the virus... - Siva-1 and an alternative splice form lacking the death domain, Siva-2, similarly induce apoptosis in T lymphocytes via a caspase-dependent mitochondrial pathwayBénédicte Py
Departement de Maladies Infectieuses, Institut Cochin, Institut National de la Sante et de la Recherche Medicale U567, Centre National de la Recherche Scientifique UMR8104, Universite Paris 5, Paris, France
J Immunol 172:4008-17. 2004..These results indicate that Siva-1 and Siva-2 mediate apoptosis in T lymphocytes via a caspase-dependent mitochondrial pathway that likely involves both cytoplasmic and nuclear events... - The Vpr protein from HIV-1: distinct roles along the viral life cycleErwann Le Rouzic
Institut Cochin, Department of Infectious Diseases, INSERM U567, CNRS UMR8104, Universite Paris 5, Paris, France
Retrovirology 2:11. 2005..In this review, we will mainly focus on vpr from HIV-1 and discuss the most recent developments in our understanding of Vpr functions and its role during the virus replication cycle...