Simone Benhamou

Summary

Country: France

Publications

  1. ncbi request reprint DNA repair gene XRCC2 and XRCC3 polymorphisms and susceptibility to cancers of the upper aerodigestive tract
    Simone Benhamou
    INSERM and Evry University, EMI 00 06, Statistical Methods and Genetic Epidemiology of Multifactorial Diseases, Evry, France
    Int J Cancer 112:901-4. 2004
  2. ncbi request reprint ERCC2 /XPD gene polymorphisms and lung cancer: a HuGE review
    Simone Benhamou
    Institut National de la Santé et de la Recherche Médicale Evry University, 91034 Evry, France
    Am J Epidemiol 161:1-14. 2005
  3. ncbi request reprint Meta- and pooled analyses of the effects of glutathione S-transferase M1 polymorphisms and smoking on lung cancer risk
    Simone Benhamou
    INSERM U521, EMI 00 06, Evry, France
    Carcinogenesis 23:1343-50. 2002
  4. ncbi request reprint DNA adducts in normal bladder tissue and bladder cancer risk
    Simone Benhamou
    INSERM and Evry University EMI 00 06, Statistical Methods and Genetic Epidemiology of Multifactorial Diseases, Evry, France
    Mutagenesis 18:445-8. 2003
  5. doi request reprint Variants in DNA double-strand break repair and DNA damage-response genes and susceptibility to lung and head and neck cancers
    Patrick Danoy
    Centre National de Genotypage, Evry, France
    Int J Cancer 123:457-63. 2008
  6. ncbi request reprint ERCC2/XPD gene polymorphisms and cancer risk
    Simone Benhamou
    EMI 00 06, INSERM Universite d Evry, 91034 Evry
    Mutagenesis 17:463-9. 2002
  7. ncbi request reprint CYP1A1, GSTM1 and GSTT1 polymorphisms and lung cancer: a pooled analysis of gene-gene interactions
    Paolo Vineis
    Imperial College London, London, UK
    Biomarkers 9:298-305. 2004
  8. ncbi request reprint Myeloperoxidase G-463A polymorphism and lung cancer: a HuGE genetic susceptibility to environmental carcinogens pooled analysis
    Emanuela Taioli
    University of Pittsburgh, Cancer Institute, Pittsburgh, Pensylvania 15232, USA
    Genet Med 9:67-73. 2007
  9. ncbi request reprint Evidence of gene gene interactions in lung carcinogenesis in a large pooled analysis
    Paolo Vineis
    Epidemiology Department, Univerisitá degli Studi di Torino, 10126 Torino, Italy
    Carcinogenesis 28:1902-5. 2007
  10. ncbi request reprint Polymorphism discovery in 62 DNA repair genes and haplotype associations with risks for lung and head and neck cancers
    Stefan Michiels
    Department of Biostatistics and Epidemiology, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France
    Carcinogenesis 28:1731-9. 2007

Detail Information

Publications27

  1. ncbi request reprint DNA repair gene XRCC2 and XRCC3 polymorphisms and susceptibility to cancers of the upper aerodigestive tract
    Simone Benhamou
    INSERM and Evry University, EMI 00 06, Statistical Methods and Genetic Epidemiology of Multifactorial Diseases, Evry, France
    Int J Cancer 112:901-4. 2004
    ..3, 95% CI: 0.2-0.7). These findings provide evidence for the view that polymorphisms in DNA repair genes may modify individual susceptibility to smoking-related cancers...
  2. ncbi request reprint ERCC2 /XPD gene polymorphisms and lung cancer: a HuGE review
    Simone Benhamou
    Institut National de la Santé et de la Recherche Médicale Evry University, 91034 Evry, France
    Am J Epidemiol 161:1-14. 2005
    ....
  3. ncbi request reprint Meta- and pooled analyses of the effects of glutathione S-transferase M1 polymorphisms and smoking on lung cancer risk
    Simone Benhamou
    INSERM U521, EMI 00 06, Evry, France
    Carcinogenesis 23:1343-50. 2002
    ..08, 95% CI 0.98-1.18) and no evidence of interaction between GSTM1 genotype and either smoking status or cumulative tobacco consumption...
  4. ncbi request reprint DNA adducts in normal bladder tissue and bladder cancer risk
    Simone Benhamou
    INSERM and Evry University EMI 00 06, Statistical Methods and Genetic Epidemiology of Multifactorial Diseases, Evry, France
    Mutagenesis 18:445-8. 2003
    ..5 and 2.2 (95% CI 0.8-6.1) for adduct levels >18.5. These findings provide some evidence that DNA adducts in bladder tissue might predict smoking-induced bladder cancer. Larger studies are still warranted to confirm these results...
  5. doi request reprint Variants in DNA double-strand break repair and DNA damage-response genes and susceptibility to lung and head and neck cancers
    Patrick Danoy
    Centre National de Genotypage, Evry, France
    Int J Cancer 123:457-63. 2008
    ..The 3 genes are key players for regulating the efficiency of DSB repair. Large-scale studies are needed to show if any of these 3 variants are truly associated with an increased risk of cancer...
  6. ncbi request reprint ERCC2/XPD gene polymorphisms and cancer risk
    Simone Benhamou
    EMI 00 06, INSERM Universite d Evry, 91034 Evry
    Mutagenesis 17:463-9. 2002
    ....
  7. ncbi request reprint CYP1A1, GSTM1 and GSTT1 polymorphisms and lung cancer: a pooled analysis of gene-gene interactions
    Paolo Vineis
    Imperial College London, London, UK
    Biomarkers 9:298-305. 2004
    ..7 (95% CI = 0.5-15.3). An association between lung cancer and the homozygous CYP1A1*2A genotype is confirmed. An apparent and biologically plausible interaction is suggested between this genotype and GSTM1...
  8. ncbi request reprint Myeloperoxidase G-463A polymorphism and lung cancer: a HuGE genetic susceptibility to environmental carcinogens pooled analysis
    Emanuela Taioli
    University of Pittsburgh, Cancer Institute, Pittsburgh, Pensylvania 15232, USA
    Genet Med 9:67-73. 2007
    ..The myeloperoxidase G-463A polymorphism was significantly protective in "ever" smokers but not in "never" smokers. Myeloperoxidase is a key enzyme in tobacco-induced carcinogenesis...
  9. ncbi request reprint Evidence of gene gene interactions in lung carcinogenesis in a large pooled analysis
    Paolo Vineis
    Epidemiology Department, Univerisitá degli Studi di Torino, 10126 Torino, Italy
    Carcinogenesis 28:1902-5. 2007
    ..People with rare combinations of common gene variants have a high risk of cancer and can be assimilated to subjects with highly penetrant mutations...
  10. ncbi request reprint Polymorphism discovery in 62 DNA repair genes and haplotype associations with risks for lung and head and neck cancers
    Stefan Michiels
    Department of Biostatistics and Epidemiology, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France
    Carcinogenesis 28:1731-9. 2007
    ..05). These results hint to a few potential candidates for further investigation in larger studies...
  11. ncbi request reprint A homologous recombination defect affects replication-fork progression in mammalian cells
    Fayza Daboussi
    UMR 217 CNRS, Institut de Radiobiologie Cellulaire et Moleculaire, 18 route du Panorama, 92265, Fontenay aux Roses, Cedex, France
    J Cell Sci 121:162-6. 2008
    ..These data reveal a novel role for HR, different from the reactivation of stalled replication forks, which may play an important role in genome stability and thus in tumor protection...
  12. doi request reprint A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25
    Rayjean J Hung
    International Agency for Research on Cancer IARC, Lyon 69008, France
    Nature 452:633-7. 2008
    ..Our results provide compelling evidence of a locus at 15q25 predisposing to lung cancer, and reinforce interest in nicotinic acetylcholine receptors as potential disease candidates and chemopreventative targets...
  13. doi request reprint Meta-analysis and pooled analysis of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancers: a HuGE-GSEC review
    Leonor Varela-Lema
    Department of Preventive Medicine and Public Health, University of Santiago de Compostela, Santiago de Compostela, Spain
    Genet Med 10:369-84. 2008
    ..1-4.5) in ever smokers. A joint effect was observed for GSTM1 homozygous deletion and the CYP1A1 m1m2 variant on cancer risk. Our findings suggest that tobacco use and genetic factors play a significant role in oral and pharyngeal cancer...
  14. doi request reprint Multiple ADH genes are associated with upper aerodigestive cancers
    Mia Hashibe
    International Agency for Research on Cancer, Lyon, France
    Nat Genet 40:707-9. 2008
    ..0002 and 0.065, respectively). Both gene effects were independent of each other, implying that multiple ADH genes may be involved in upper aerodigestive cancer etiology...
  15. ncbi request reprint Combined COMT and GST genotypes and hormone replacement therapy associated breast cancer risk
    Katja Mitrunen
    Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Helsinki, Finland
    Pharmacogenetics 12:67-72. 2002
    ..84-45.0) of breast cancer in this study group. These results suggest that the use of HRT could substantially increase the risk of breast cancer among women with specific combinations of the at-risk genotypes of COMT and GST genes...
  16. ncbi request reprint Association of metabolic gene polymorphisms with tobacco consumption in healthy controls
    Kim M Smits
    University Maastricht, Maastricht, The Netherlands
    Int J Cancer 110:266-70. 2004
    ..No association between polymorphisms in the genes studied and tobacco consumption was observed; therefore, no effect of these genes on smoking behavior should be expected...
  17. ncbi request reprint O6-Alkylguanine-DNA-alkyltransferase activity in peripheral leukocytes, smoking and risk of lung cancer
    Paolo Boffetta
    International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon, France
    Cancer Lett 180:33-9. 2002
    ..Reduced AGT activity was not clearly associated with increased lung cancer risk in either smokers or non-smokers. However, the small size of our study argues for a prudent interpretation of our results...
  18. ncbi request reprint Microsomal epoxide hydrolase polymorphisms and lung cancer risk: a quantitative review
    Won Jin Lee
    International Agency for Research on Cancer, 150 cours Albert Thomas, 69008 Lyon, France
    Biomarkers 7:230-41. 2002
    ..If present, this effect may vary among different populations, possibly because of interaction with genetic or environmental factors...
  19. ncbi request reprint Point: myeloperoxidase -463G --> a polymorphism and lung cancer risk
    Anne Feyler
    Unit of Cancer Epidemiology INSERM U521, Gustave Roussy Institute, 94805 Villejuif, France
    Cancer Epidemiol Biomarkers Prev 11:1550-4. 2002
    ..68 (95% CI: 0.5-0.93). However, because of the heterogeneity in individual study results, additional large case-control studies are warranted to provide a more definitive conclusion...
  20. ncbi request reprint CYP1A1 T3801 C polymorphism and lung cancer: a pooled analysis of 2451 cases and 3358 controls
    Paolo Vineis
    Universita degli Studi di Torino, Torino, Italy
    Int J Cancer 104:650-7. 2003
    ..The analyses were more inconsistent and failed to reach statistical significance in Asians. This observation might be due to design specificities or unknown effect modifiers in the Asian studies...
  21. ncbi request reprint Pooled analysis of the CYP1A1 exon 7 polymorphism and lung cancer (United States)
    Loic Le Marchand
    Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    Cancer Causes Control 14:339-46. 2003
    ....
  22. ncbi request reprint Meta- and pooled analyses of GSTM1, GSTT1, GSTP1, and CYP1A1 genotypes and risk of head and neck cancer
    Mia Hashibe
    International Agency for Research on Cancer, Lyon, France
    Cancer Epidemiol Biomarkers Prev 12:1509-17. 2003
    ....
  23. ncbi request reprint Secondhand smoke exposure in adulthood and risk of lung cancer among never smokers: a pooled analysis of two large studies
    Paul Brennan
    International Agency for Research on Cancer, Lyon, France
    Int J Cancer 109:125-31. 2004
    ..Clear dose-response relationships consistent with a causal association were observed between exposure to secondhand smoke from spousal, workplace and social sources and the development of lung cancer among never smokers...
  24. ncbi request reprint Exon 5 polymorphisms in the O6-alkylguanine DNA alkyltransferase gene and lung cancer risk in non-smokers exposed to second-hand smoke
    Catherine Cohet
    International Agency of Research on Cancer, Lyon, France
    Cancer Epidemiol Biomarkers Prev 13:320-3. 2004
    ....
  25. ncbi request reprint Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers, and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium
    Mia Hashibe
    Gene Environment Epidemiology Group, International Agency for Research on Cancer, 150 cours Albert Thomas, 69008 Lyon, France
    J Natl Cancer Inst 99:777-89. 2007
    ....
  26. ncbi request reprint Pooled analysis of alcohol dehydrogenase genotypes and head and neck cancer: a HuGE review
    Paul Brennan
    International Agency for Research on Cancer, Lyon, France
    Am J Epidemiol 159:1-16. 2004
    ..These considerations suggest the potential for the organization of a consortium of investigators conducting studies in this field...
  27. doi request reprint Lack of association between serum antibodies of Chlamydia pneumoniae infection and the risk of lung cancer
    Jennifer S Smith
    Int J Cancer 123:2469-71. 2008