A L Benabid

Summary

Country: France

Publications

  1. ncbi Deep-brain stimulation in Parkinson's disease: long-term efficacy and safety - What happened this year?
    Alim Louis Benabid
    INSERM U318 Preclinical Neurosciences and Joseph Fourier Grenoble University, Centre Hospitalier Universitaire Albert Michallon, Grenoble, France
    Curr Opin Neurol 18:623-30. 2005
  2. ncbi Subthalamic stimulation for Parkinson's disease
    A L Benabid
    Department of Neurosciences, University Hospital of Grenoble, Grenoble, France
    Arch Med Res 31:282-9. 2000
  3. ncbi Imaging of subthalamic nucleus and ventralis intermedius of the thalamus
    Alim Louis Benabid
    Department of Clinical and Biological Neurosciences, Institut National de la Sante et de la Recherche Medicale, Preclinical Neurosciences U 318, Joseph Fourier University of Grenoble, Hopital A Michallon, France
    Mov Disord 17:S123-9. 2002
  4. ncbi Deep brain stimulation of the corpus luysi (subthalamic nucleus) and other targets in Parkinson's disease. Extension to new indications such as dystonia and epilepsy
    A L Benabid
    Department of Neurosurgery, CHU A Michallon, Grenoble, France
    J Neurol 248:III37-47. 2001
  5. ncbi Antiepileptic effect of high-frequency stimulation of the subthalamic nucleus (corpus luysi) in a case of medically intractable epilepsy caused by focal dysplasia: a 30-month follow-up: technical case report
    Alim Louis Benabid
    Department of Neurosurgery, University Hospital of Grenoble, and INSERM Research Unit U318, Grenoble, France
    Neurosurgery 50:1385-91; discussion 1391-2. 2002
  6. ncbi Robotics in neurosurgery: which tools for what?
    A L Benabid
    Neurosurgery and INSERM U318, Department of Neurosciences, Grenoble, France
    Acta Neurochir Suppl 98:43-50. 2006
  7. ncbi Therapeutic electrical stimulation of the central nervous system
    Alim Louis Benabid
    INSERM U318, Universite Joseph Fourier, CHU Albert Michallon, pavilion B, BP 217, 38043 Grenoble, France
    C R Biol 328:177-86. 2005
  8. ncbi Mechanisms of deep brain stimulation
    Alim L Benabid
    Neurosciences Department, Joseph Fourier University, Centre Hospitalier Universitaire, Grenoble, France
    Mov Disord 17:S73-4. 2002
  9. ncbi Deep brain stimulation for Parkinson's disease
    Alim Louis Benabid
    INSERM U318 Preclinical Neurosciences, Joseph Fourier University, Pavillon B, University Hospital, 38043, Grenoble, France
    Curr Opin Neurobiol 13:696-706. 2003
  10. ncbi A putative generalized model of the effects and mechanism of action of high frequency electrical stimulation of the central nervous system
    Alim Louis Benabid
    INSERM U318, Universite Joseph Fourier, CHU Albert Michallon, Grenoble Cedex 9, France
    Acta Neurol Belg 105:149-57. 2005

Collaborators

Detail Information

Publications92

  1. ncbi Deep-brain stimulation in Parkinson's disease: long-term efficacy and safety - What happened this year?
    Alim Louis Benabid
    INSERM U318 Preclinical Neurosciences and Joseph Fourier Grenoble University, Centre Hospitalier Universitaire Albert Michallon, Grenoble, France
    Curr Opin Neurol 18:623-30. 2005
    ..High-frequency stimulation of the subthalamic nucleus has become the surgical therapy of choice. This review concentrates on recent data on long-term results and side-effects, after 12 years of practice using this technique...
  2. ncbi Subthalamic stimulation for Parkinson's disease
    A L Benabid
    Department of Neurosciences, University Hospital of Grenoble, Grenoble, France
    Arch Med Res 31:282-9. 2000
    ..6, 48.6, and 27%, respectively, when compared with the previous preoperative level. From our experience, HFS of the STN could be considered the surgical therapy of choice at advanced stages of Parkinson's disease...
  3. ncbi Imaging of subthalamic nucleus and ventralis intermedius of the thalamus
    Alim Louis Benabid
    Department of Clinical and Biological Neurosciences, Institut National de la Sante et de la Recherche Medicale, Preclinical Neurosciences U 318, Joseph Fourier University of Grenoble, Hopital A Michallon, France
    Mov Disord 17:S123-9. 2002
    ..These shortcomings no doubt will be corrected in the near future, and the technologies will better assist us in the proper placement of electrodes, which will provide the patient with the highest possible benefit...
  4. ncbi Deep brain stimulation of the corpus luysi (subthalamic nucleus) and other targets in Parkinson's disease. Extension to new indications such as dystonia and epilepsy
    A L Benabid
    Department of Neurosurgery, CHU A Michallon, Grenoble, France
    J Neurol 248:III37-47. 2001
    ..It is therefore possible that DBS in STN as well as in other targets could become a potent therapeutic tool in the near future for neurological disorders...
  5. ncbi Antiepileptic effect of high-frequency stimulation of the subthalamic nucleus (corpus luysi) in a case of medically intractable epilepsy caused by focal dysplasia: a 30-month follow-up: technical case report
    Alim Louis Benabid
    Department of Neurosurgery, University Hospital of Grenoble, and INSERM Research Unit U318, Grenoble, France
    Neurosurgery 50:1385-91; discussion 1391-2. 2002
    ..We were encouraged by the known relationship between the STN and the nigral system, as well as by our experience with high-frequency stimulation of the STN in Parkinsonian patients...
  6. ncbi Robotics in neurosurgery: which tools for what?
    A L Benabid
    Neurosurgery and INSERM U318, Department of Neurosciences, Grenoble, France
    Acta Neurochir Suppl 98:43-50. 2006
    ..Neurosurgical robots currently available at the operating level are being described. Future evolutions, indications and ethical aspects are examined...
  7. ncbi Therapeutic electrical stimulation of the central nervous system
    Alim Louis Benabid
    INSERM U318, Universite Joseph Fourier, CHU Albert Michallon, pavilion B, BP 217, 38043 Grenoble, France
    C R Biol 328:177-86. 2005
    ..The understanding of the mechanism has opened a new field of research, which will call for reappraisal of the basic effects of electricity on the living tissues...
  8. ncbi Mechanisms of deep brain stimulation
    Alim L Benabid
    Neurosciences Department, Joseph Fourier University, Centre Hospitalier Universitaire, Grenoble, France
    Mov Disord 17:S73-4. 2002
    ..It is clear that the understanding of this strange and powerful phenomenon will profit from both clinical observation and well designed animal experiments...
  9. ncbi Deep brain stimulation for Parkinson's disease
    Alim Louis Benabid
    INSERM U318 Preclinical Neurosciences, Joseph Fourier University, Pavillon B, University Hospital, 38043, Grenoble, France
    Curr Opin Neurobiol 13:696-706. 2003
    ..Long-term changes, neural plasticity and neural protection might be induced in the network. Similar effects of stimulation and lesioning have led to the extension of this technique for other targets and diseases...
  10. ncbi A putative generalized model of the effects and mechanism of action of high frequency electrical stimulation of the central nervous system
    Alim Louis Benabid
    INSERM U318, Universite Joseph Fourier, CHU Albert Michallon, Grenoble Cedex 9, France
    Acta Neurol Belg 105:149-57. 2005
    ..iv) Retrograde activation of upstream neuronal structures, as reported in the external pallidum during stimulation of STN, might be responsible of additional jamming-like effects due to collisions with descending spikes...
  11. doi Levodopa-resistant freezing of gait and executive dysfunction in Parkinson's disease
    M U Ferraye
    Universite J Fourier Grenoble 1, INSERM, U836, Grenoble Institut des Neurosciences, Grenoble, France
    Eur Neurol 69:281-8. 2013
    ..However, since some patients develop L-FOG despite the preservation of executive functions, lesions or dysfunction of other neuronal structures are likely to be involved...
  12. ncbi Intrasubthalamic injection of 6-hydroxydopamine induces changes in the firing rate and pattern of subthalamic nucleus neurons in the rat
    Z Ni
    INSERM U.318, Neurobiologie Preclinique, CHU-Pavillon B, BP 217, 38043 Grenoble Cedex 09, France
    Synapse 40:145-53. 2001
    ....
  13. ncbi Effect of high-frequency stimulation of the subthalamic nucleus on the neuronal activities of the substantia nigra pars reticulata and ventrolateral nucleus of the thalamus in the rat
    A Benazzouz
    Laboratoire de Neurobiologie Preclinique, INSERM U 318, CHU Pavillon B, BP 217, 38043, Grenoble, France
    Neuroscience 99:289-95. 2000
    ..The reduction in tonic inhibitory drive of nigral neurons induces a disinhibition of activity in the ventrolateral motor thalamic nucleus, which should result in activation of the motor cortical system...
  14. pmc Subthalamic nucleus stimulation in tremor dominant parkinsonian patients with previous thalamic surgery
    V Fraix
    Department of Neurology, University Hospital of Grenoble, BP 217, 38043 Grenoble Cedex 9, France
    J Neurol Neurosurg Psychiatry 76:246-8. 2005
    ..The parkinsonian motor state is greatly improved by bilateral STN stimulation even in patients with previous thalamic surgery, and STN stimulation is more effective than VIM stimulation in tremor dominant parkinsonian patients...
  15. doi Effects of subthalamic nucleus stimulation and levodopa on freezing of gait in Parkinson disease
    M U Ferraye
    Université de Grenoble, INSERM U836, CHU de Grenoble, Pavillon de Neurologie, BP 217, 38043 Grenoble Cedex 9, France
    Neurology 70:1431-7. 2008
    ..We studied the effects of subthalamic nucleus (STN) stimulation vs levodopa on freezing of gait (FOG) and gait impairments in a large consecutive series of patients with Parkinson disease with bilateral STN stimulation...
  16. doi Pedunculopontine nucleus stimulation induces monocular oscillopsia
    M U Ferraye
    Universite Joseph Fourier, Grenoble, France and INSERM U836, Grenoble Institut des Neurosciences, Grenoble, France
    J Neurol Neurosurg Psychiatry 80:228-31. 2009
    ..These results emphasise the difficulty of stimulating this mesencephalic region...
  17. ncbi Effect of microiontophoretic application of dopamine on subthalamic nucleus neuronal activity in normal rats and in rats with unilateral lesion of the nigrostriatal pathway
    Z Ni
    , INSERM U.318, CHU, Pavillon B, B.P. 217, 38043 Grenoble Cedex 09, France
    Eur J Neurosci 14:373-81. 2001
    ....
  18. pmc Long term effects of bilateral subthalamic nucleus stimulation on cognitive function, mood, and behaviour in Parkinson's disease
    A Funkiewiez
    Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France
    J Neurol Neurosurg Psychiatry 75:834-9. 2004
    ..Long term effects of subthalamic nucleus (STN) stimulation on cognition, mood, and behaviour are unknown...
  19. doi Subthalamic nucleus versus pedunculopontine nucleus stimulation in Parkinson disease: synergy or antagonism?
    M U Ferraye
    University J Fourier Grenoble 1, 38041, Grenoble, France
    J Neural Transm 118:1469-75. 2011
    ....
  20. ncbi Ineffective subthalamic nucleus stimulation in levodopa-resistant postischemic parkinsonism
    P Krack
    Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France
    Neurology 54:2182-4. 2000
    ..This case suggests that parkinsonian patients who do not have a good response to levodopa or in whom a postsynaptic dopaminergic lesion can be shown may not be good candidates for STN surgery...
  21. ncbi Functional neurosurgery: past, present, and future
    A L Benabid
    University Joseph Fourier, Grenoble, France
    Clin Neurosurg 52:265-70. 2005
  22. ncbi Implication of the subthalamic nucleus in the pathophysiology and pathogenesis of Parkinson's disease
    A Benazzouz
    Laboratoire de Neurobiologie Preclinique, INSERM U 318, Grenoble, France
    Cell Transplant 9:215-21. 2000
    ..The evidence reviewed in the present article clearly demonstrates that the STN is implicated in the pathophysiology and pathogenesis of Parkinson's disease...
  23. ncbi Is there a role for physiotherapy during deep brain stimulation surgery in patients with Parkinson's disease?
    E Chevrier
    Department of Neurology, Movement Disorders Unit, Grenoble University Hospital, Grenoble, Cedex 09, France
    Eur J Neurol 13:496-8. 2006
    ..All patients except one experienced physical pain and psychological suffering, alleviated by physiotherapy. These preliminary results need to be confirmed in a prospective randomized study...
  24. doi High frequency deep brain stimulation of the subthalamic nucleus versus continuous subcutaneous apomorphine infusion therapy: a review
    R Carron
    Department of Neurosurgery, University Hospital, Grenoble, France
    J Neural Transm 118:915-24. 2011
    ....
  25. ncbi Time-course of changes in firing rates and firing patterns of subthalamic nucleus neuronal activity after 6-OHDA-induced dopamine depletion in rats
    Z G Ni
    , INSERM U. 318, CHU - Pavillon B, B.P. 217, 38043 Cedex 09, Grenoble, France
    Brain Res 899:142-7. 2001
    ....
  26. ncbi Pyramidal tract side effects induced by deep brain stimulation of the subthalamic nucleus
    G Tommasi
    Department of Neurology, University Hospital, Joseph Fourier University, Grenoble, France
    J Neurol Neurosurg Psychiatry 79:813-9. 2008
    ..To study the pyramidal tract side effects (PTSEs) induced by the spread of current from the subthalamic nucleus (STN) to the pyramidal tract (PT), in patients with parkinsonism undergoing STN stimulation...
  27. ncbi Contribution of dynamic contrast MR imaging to the differentiation between dural metastasis and meningioma
    S Kremer
    Neuroradiology Department, University Hospital, Nancy, France
    Neuroradiology 46:642-8. 2004
    ..To determine the perfusion-sensitive characteristics of cerebral dural metastases and compare them with the data on meningiomas...
  28. ncbi Predictors of effective bilateral subthalamic nucleus stimulation for PD
    P D Charles
    Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France
    Neurology 59:932-4. 2002
    ..Younger age and levodopa responsiveness predict a favorable response to bilateral STN stimulation. For individual PD symptoms, those that improve with a suprathreshold dose levodopa challenge are likely to improve with stimulation...
  29. ncbi Effect of bilateral subthalamic nucleus stimulation on parkinsonian gait
    J Xie
    Department of Clinical and Biological Neurosciences, Centre Hospitalier Universitaire de Grenoble, France
    J Neurol 248:1068-72. 2001
    ..The UPDRS motor score was significantly (p < 0.001) decreased after both stimulation and levodopa. In conclusion, STN stimulation is effective on parkinsonian gait...
  30. ncbi Unilateral lesion of the nigrostriatal pathway induces an increase of neuronal activity of the pedunculopontine nucleus, which is reversed by the lesion of the subthalamic nucleus in the rat
    S Breit
    INSERM U318, Laboratoire de Neuroscience Preclinique, CHU-Pavillon B, BP 217, 38043 Grenoble Cedex 09, France
    Eur J Neurosci 14:1833-42. 2001
    ....
  31. pmc Clinical and economic results of bilateral subthalamic nucleus stimulation in Parkinson's disease
    V Fraix
    Department of Neurology and Neurosurgery, Grenoble University Hospital and INSERM U318 Joseph Fourier University, Grenoble Cedex 9, France
    J Neurol Neurosurg Psychiatry 77:443-9. 2006
    ..High frequency stimulation of the subthalamic nucleus (STN) is an alternative but expensive neurosurgical treatment for parkinsonian patients with levodopa induced motor complications...
  32. ncbi Mirthful laughter induced by subthalamic nucleus stimulation
    P Krack
    Neuroscience Department, University of Grenoble, Grenoble, France
    Mov Disord 16:867-75. 2001
    ..Our report suggests that the STN, with its sensorimotor, cognitive, and limbic parts is not only involved in motor, but also in psychomotor regulation...
  33. ncbi Intraoperative microrecordings of the subthalamic nucleus in Parkinson's disease
    Abdelhamid Benazzouz
    Department of Clinical and Biological Neurosciences, Institut National de la Santé et de la Recherche Médicale U 318, University Hospital A Michallon, Pavillon B, Grenoble, France
    Mov Disord 17:S145-9. 2002
    ..In conclusion, microelectrode recording of the subthalamic area improves the accuracy of targeting the STN...
  34. ncbi Pretargeting for the implantation of stimulation electrodes into the subthalamic nucleus: a comparative study of magnetic resonance imaging and ventriculography
    Sorin Breit
    INSERM U 318, Department of Neurobiology, University Joseph Fourier, Grenoble, France
    Neurosurgery 58:ONS83-95. 2006
    ..The purpose of this study was to evaluate the accuracy of the preoperative MRI targeting as compared with ventriculography in terms of both the STN target as well as the internal landmarks...
  35. ncbi Deep brain stimulation of the subthalamic nucleus in Parkinson's disease 1993-2003: where are we 10 years on?
    K Ashkan
    Department of Clinical Neurosciences, University of Joseph Fourier, Grenoble, France
    Br J Neurosurg 18:19-34. 2004
    ..The evolution of the surgical technique and long-term patients' outcome are further discussed...
  36. ncbi Bilateral subthalamic nucleus stimulation improves health-related quality of life in PD
    E Lagrange
    Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France
    Neurology 59:1976-8. 2002
    ..All aspects of quality of life, including motor (+48%), systemic (+34%), emotional (+29%), and social (+63%) dimensions, significantly improved with long-term STN stimulation...
  37. ncbi Effects of levodopa and subthalamic nucleus stimulation on cognitive and affective functioning in Parkinson's disease
    Aurélie Funkiewiez
    Department of Clinical and Biological Neurosciences, University Hospital of Grenoble, and INSERM U318, Joseph Fourier University of Grenoble, Grenoble, France
    Mov Disord 21:1656-62. 2006
    ..To conclude, there were significant but contrasting effects of levodopa and STN stimulation on cognition and affective functions...
  38. ncbi Effect of bilateral stimulation of the subthalamic nucleus on parkinsonian voice
    M Gentil
    INSERM, Unité 318, Centre Hospitalier Universitaire de Grenoble, Grenoble, France
    Brain Lang 78:233-40. 2001
    ..Relative intensity was unchanged in both conditions. Further acoustic analyses are warranted to clarify the role of STN stimulation on parkinsonian speech...
  39. ncbi Comparison of two techniques to postoperatively localize the electrode contacts used for subthalamic nucleus stimulation
    Serge Pinto
    Department of Neurology, Centre Hospitalier Universitaire de Grenoble, and INSERM U318, Neurosciences Précliniques, Grenoble, France
    Neurosurgery 60:285-92; discussion 292-4. 2007
    ..To our knowledge, this is the first study attempting to compare the "gold standard" of stereotactic accuracy (Vg) with the anatomic resolution provided by MRI scans...
  40. doi Middle short gyrus of the insula implicated in pain processing
    Afif Afif
    Neurosurgery Department, INSERM U318, Grenoble University Hospital, BP 217, 38043 Grenoble Cedex 9, France
    Pain 138:546-55. 2008
    ..All sites inducing painful sensations were restricted to the upper portion of the middle short gyrus of the insula. The findings of this study suggest that middle short gyrus is involved in the processing of pain-producing stimuli...
  41. doi Improvement in Parkinson disease by subthalamic nucleus stimulation based on electrode placement: effects of reimplantation
    Mathieu Anheim
    Department of Neurology, University Hospital A Michallon, Grenoble, France
    Arch Neurol 65:612-6. 2008
    ..The misplacement of electrodes is a possible explanation for suboptimal response to bilateral subthalamic nucleus (STN) stimulation in patients with Parkinson disease...
  42. ncbi Response to levodopa in parkinsonian patients with bilateral subthalamic nucleus stimulation
    Elena Moro
    Department of Clinical and Biological Neurosciences and INSERM U318, Joseph Fourier University, CHU de Grenoble, Grenoble, France
    Brain 125:2408-17. 2002
    ..In addition, the persistence of levodopa intake after surgery might hinder this beneficial process...
  43. ncbi Microarray RNA quantification assay for large-scale nanosamples analysis
    I Dupre
    Laboratoire de Neurosciences Précliniques, INSERM U318, Universite J Fourier, CHR Grenoble, France
    Biotechniques 31:856-8, 860. 2001
    ..Furthermore, with this procedure, the reproducibility, sensitivity, and accuracy of the assay are notably improved as compared to current methods...
  44. ncbi Muscle transfection by electroporation with high-voltage and short-pulse currents provides high-level and long-lasting gene expression
    J M Vicat
    INSERM U 318, Laboratoire de Neurobiophysique UJFG, Centre Hospitalier Universitaire, Grenoble, France
    Hum Gene Ther 11:909-16. 2000
    ..In conclusion, electroporation with high-voltage and short-pulse currents provides high-level and long-lasting gene expression in muscle...
  45. ncbi Effects of 6-hydroxydopamine-induced severe or partial lesion of the nigrostriatal pathway on the neuronal activity of pallido-subthalamic network in the rat
    S Breit
    INSERM U 318, Department of Preclinical Neurobiology, Joseph Fourier University, Grenoble, France
    Exp Neurol 205:36-47. 2007
    ..These data suggest that in the GP-STN-GP network, the excitatory influence of the STN-GP pathway overrides that of the GABAergic GP-STN pathway, questioning the classical model of basal ganglia organization...
  46. ncbi [Deep brain stimulation]
    V Fraix
    Departement de Neurologie, Centre Hospitalier Universitaire de Grenoble, Grenoble
    Rev Neurol (Paris) 160:511-21. 2004
    ..Such studies, including cost benefit studies would be useful to assess the respective value of these different techniques...
  47. pmc Effect of stimulation of the subthalamic nucleus on oral control of patients with parkinsonism
    M Gentil
    INSERM, Unit 318, CHU Grenoble, France
    J Neurol Neurosurg Psychiatry 67:329-33. 1999
    ..To assess the oral system of parkinsonian patients treated with chronic stimulation of the bilateral subthalamic nucleus (STN) to evaluate precisely the effectiveness of this procedure on the articulatory organs...
  48. ncbi Effect of bilateral deep-brain stimulation on oral control of patients with parkinsonism
    M Gentil
    INSERM Unit 318, CHU Grenoble, France
    Eur Neurol 44:147-52. 2000
    ..The target of stimulation differently influences the oral system and modulates neuronal structures involved in speech...
  49. ncbi Bilateral subthalamic stimulation effects on oral force control in Parkinson's disease
    Serge Pinto
    Service de Neurologie, CHU de Grenoble, BP 217, 38043 Grenoble Cedex 09, France
    J Neurol 250:179-87. 2003
    ..Nevertheless, to confirm the persistence of the beneficial effect of STN stimulation on parkinsonian dysarthria, a longitudinal evaluation is still needed...
  50. ncbi The role of the temporal pole in the genesis of temporal lobe seizures
    Philippe Kahane
    Neurophysiopathology of the Epilepsy, Grenoble University Hospital, Grenoble, France
    Epileptic Disord 4:S51-8. 2002
    ..However a clear-cut distinction between the two groups remains rather difficult in the absence of intracerebral recordings...
  51. doi Functional neurosurgery for movement disorders: a historical perspective
    Alim Louis Benabid
    CEA Minatec LETI and INSERM, Joseph Fourier University, Grenoble, France
    Prog Brain Res 175:379-91. 2009
    ..The new field of compensation of deficits will then become part of the field of functional neurosurgery...
  52. ncbi Survival of midbrain dopaminergic cells after lesion or deep brain stimulation of the subthalamic nucleus in MPTP-treated monkeys
    Bradley A Wallace
    Department of Clinical and INSERM U318 Preclinical Neurosciences, University Joseph Fourier, Grenoble, France
    Brain 130:2129-45. 2007
    ..In summary, these results indicated that STN alteration offered neuroprotection to dopaminergic cells that would normally die as part of the disease process...
  53. ncbi Postoperative management of subthalamic nucleus stimulation for Parkinson's disease
    Paul Krack
    Department of Clinical and Biological Neurosciences, Service de Neurologie, Centre Hospitalier Universitaire de Grenoble, Grenoble, France
    Mov Disord 17:S188-97. 2002
    ..Neurosurgeons who perform DBS need to understand the principles that guide the postoperative adaptation of treatment. This article defines guidelines for setting stimulation parameters, adapting drugs and managing adverse effects...
  54. ncbi Intraoperative micro- and macrostimulation of the subthalamic nucleus in Parkinson's disease
    Pierre Pollak
    Department of Clinical and Biological Neurosciences, Service de Neurologie, Centre Hospitalier Universitaire de Grenoble, Grenoble, France
    Mov Disord 17:S155-61. 2002
    ..New skills are needed to assess all stimulation-induced effects and interpret them in anatomo-functional terms...
  55. ncbi Treatment results: Parkinson's disease
    Pierre Pollak
    Department of Clinical and Biological Neurosciences, Service de Neurologie, Centre Hospitalier Universitaire de Grenoble, France
    Mov Disord 17:S75-83. 2002
    ..Intracranial electrode implantation can induce a hematoma or contusion. Most authors agree that the benefit to risk ratio of DBS is favorable...
  56. ncbi An unsupervised automatic method for sorting neuronal spike waveforms in awake and freely moving animals
    Tetyana I Aksenova
    Institute of Applied System Analysis, Ukrainian Academy of Sciences, Prospekt Peremogy 37, 03056 Kiev, Ukraine
    Methods 30:178-87. 2003
    ..The new method of spike sorting was tested on simulated and real data and performed better than other approaches currently used in neurophysiology...
  57. doi Effects of subthalamic nucleus stimulation on motor cortex excitability in Parkinson's disease
    Valerie Fraix
    Department of Neurology, University Hospital of Grenoble and INSERM U836, Joseph Fourier University, 38000 Grenoble, France
    Clin Neurophysiol 119:2513-8. 2008
    ..To study the effects of subthalamic nucleus (STN) stimulation on motor cortex excitability in Parkinson's disease (PD)...
  58. doi De novo and long-term l-Dopa induce both common and distinct striatal gene profiles in the hemiparkinsonian rat
    Michele El Atifi-Borel
    Institut National de la Sante et de la Recherche Medicale, Grenoble, France
    Neurobiol Dis 34:340-50. 2009
    ..Processes such as growth, synaptogenesis, neurogenesis and cell proliferation may be particularly relevant to the long-term action of l-Dopa...
  59. doi Filtering out deep brain stimulation artifacts using a nonlinear oscillatory model
    Tatyana I Aksenova
    Unit 318, INSERM, 38043 Grenoble, Cedex 09, France, and Institute of Applied System Analysis, Ukrainian Academy of Sciences, Kiev 03056, Ukraine
    Neural Comput 21:2648-66. 2009
    ..The proposed algorithm was tested using recordings collected from patients during the stimulation. This was then compared to existing methods and showed the best performance...
  60. ncbi Effect of bilateral stimulation of the subthalamic nucleus on parkinsonian dysarthria
    Michèle Gentil
    INSERM, Unit 318, CHU, Service neurologie, BP 217 38043, Grenoble Cedex 9, France
    Brain Lang 85:190-6. 2003
    ..We also noted a large beneficial effect on voice with a significant improvement in respiratory and phonatory functions...
  61. ncbi Five-year follow-up of bilateral stimulation of the subthalamic nucleus in advanced Parkinson's disease
    Paul Krack
    Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France
    N Engl J Med 349:1925-34. 2003
    ..Although the short-term benefits of bilateral stimulation of the subthalamic nucleus in patients with advanced Parkinson's disease have been well documented, the long-term outcomes of the procedure are unknown...
  62. ncbi Coordinated and spatial upregulation of arc in striatonigral neurons correlates with L-dopa-induced behavioral sensitization in dyskinetic rats
    Véronique Sgambato-Faure
    INSERM U318, Laboratoire de Neurosciences Précliniques, CHU Pavillon B, Grenoble, France
    J Neuropathol Exp Neurol 64:936-47. 2005
    ....
  63. ncbi Unsupervised Spike Sorting of extracellular electrophysiological recording in subthalamic nucleus of Parkinsonian patients
    Olga K Chibirova
    Laboratory of Preclinical Neuroscience INSERM U318 CHUG Michallon Pavillon B BP 217 F 38043 Grenoble Cedex 9 France
    Biosystems 79:159-71. 2005
    ..We analyzed separately two brain hemispheres. For each hemisphere the percentage of units of each activity pattern were calculated. The results were compared for the first and the second operated hemispheres of each patient and in total...
  64. doi Rationale for hypothalamus-deep brain stimulation in food intake disorders and obesity
    N Torres
    CEA CLINATEC, Grenoble, France
    Adv Tech Stand Neurosurg 36:17-30. 2011
    ..All those elements have made possible the recent regain of interest in DBS for morbid obesity and open an exciting new area of research in neurosurgery and endocrinology...
  65. doi Body fat and body weight reduction following hypothalamic deep brain stimulation in monkeys: an intraventricular approach
    N Torres
    Unite INSERM, U836 UJFG, GIN, France
    Int J Obes (Lond) 36:1537-44. 2012
    ....
  66. ncbi Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease
    D Blum
    Unité Mixte INSERM UJF E0108, Neurodégénérescence et Plasticité, CHU Michallon, Pavillon de Neurologie, BP217, 38043 Cedex 9, Grenoble, France
    Prog Neurobiol 65:135-72. 2001
    ..This review reports recent data concerning the biochemical and molecular apoptotic mechanisms underlying the experimental models of PD and correlates them to the phenomena occurring in human disease...
  67. ncbi The temporopolar cortex plays a pivotal role in temporal lobe seizures
    Stephan Chabardes
    Department of Neurosurgery, CHU Michallon, Grenoble, France
    Brain 128:1818-31. 2005
    ..Moreover, the involvement of the TP cortex at the onset of the seizures is a good predicting factor for postoperative seizure outcome...
  68. ncbi Changes induced by levodopa and subthalamic nucleus stimulation on parkinsonian speech
    Serge Pinto
    Neurosciences Précliniques, INSERM Unité 318, Grenoble, France
    Mov Disord 20:1507-15. 2005
    ..These hypotheses may be helpful for better understanding and management of STN stimulation effects on motor speech and skeleton-motor subsystems...
  69. doi Deep brain stimulation of the subthalamic nucleus for the treatment of Parkinson's disease
    Alim Louis Benabid
    Department of Neurosurgery and Neurology, University of Grenoble, CHU Albert Michallon, Grenoble, France
    Lancet Neurol 8:67-81. 2009
    ..Further improvements, through basic research and methodological innovations, should make it applicable to earlier stages of the disease and increase its availability to patients in developing countries...
  70. ncbi Lifetime of Itrel II pulse generators for subthalamic nucleus stimulation in Parkinson's disease
    Mathieu Anheim
    Department of Neurology, University Hospital A Michallon, Grenoble, France
    Mov Disord 22:2436-9. 2007
    ..A close monitoring of patients and an anticipation of IPG replacement in the case of a low-battery signal are recommended...
  71. ncbi The impact on Parkinson's disease of electrical parameter settings in STN stimulation
    E Moro
    Department of Clinical and Biological Neurosciences and INSERM U318, Joseph Fourier University, CHU de Grenoble, France
    Neurology 59:706-13. 2002
    ..The main objective of this study was to discover how varying these electrical parameters impacted on parkinsonian motor signs...
  72. ncbi Chemoarchitectonic heterogeneities in the primate zona incerta: clinical and functional implications
    John Mitrofanis
    Department of Clinical Neurosciences, University of Joseph Fourier, Grenoble, France
    J Neurocytol 33:429-40. 2004
    ..Such clinical stimulations could well involve other systems, including those of arousal, attention and visceral control...
  73. ncbi Subthalamic nucleus stimulation and dysarthria in Parkinson's disease: a PET study
    Serge Pinto
    INSERM U318, Grenoble, France
    Brain 127:602-15. 2004
    ..STN stimulation tends to reverse these abnormal activations, which is consistent with the observed improvement of Parkinson's disease dysarthria...
  74. ncbi Effects of pulse width variations in pallidal stimulation for primary generalized dystonia
    Laurent Vercueil
    Neurology and Neurosurgery, CHU Grenoble, 38043 Grenoble, France
    J Neurol 254:1533-7. 2007
    ..Various pulse widths (from 60-450 mus) have been used for bilateral pallidal stimulation in generalized dystonia but, to date, no comparison of this parameter's effects is available...
  75. ncbi Dynamic contrast-enhanced MRI: differentiating melanoma and renal carcinoma metastases from high-grade astrocytomas and other metastases
    S Kremer
    INSERM U318, Centre Hospitalier et Universitaire de Grenoble, Hopital Michallon, 38043 Grenoble Cedex 09, France
    Neuroradiology 45:44-9. 2003
    ..59). Large, solitary, necrotic metastases can be indistinguishable from high-grade astrocytomas using conventional MRI. Demonstration of an elevated rCBV which may suggest a hypervascular lesion such as renal carcinoma or melanoma...
  76. ncbi Quantification of DNA probes on nylon microarrays using T4 polynucleotide kinase labeling
    M el Atifi
    CHRU, Equipe Transcriptome, Grenoble, France
    Biotechniques 35:262-4, 266. 2003
  77. ncbi The bacterial nucleoside N(6)-methyldeoxyadenosine induces the differentiation of mammalian tumor cells
    D Ratel
    INSERM U318, CHU Michallon, 38033 Grenoble cedex 9, France
    Biochem Biophys Res Commun 285:800-5. 2001
    ..Furthermore, the finding that a methylated nucleoside found in bacterial DNA induces a biological process might have implications in gene therapy approaches when plasmid DNAs are injected into humans...
  78. ncbi Long oligonucleotide arrays on nylon for large-scale gene expression analysis
    M el Atifi
    CHRU, Equipe Transcriptome, INSERM U318, Laboratoire de Neurosciences Précliniques, Grenoble, France
    Biotechniques 33:612-6, 618. 2002
    ..The long oligonucleotide array thus provides a very convenient method for the analysis of gene expression patterns in biological specimens and in clinical research...
  79. doi Monophasic but not biphasic pulses induce brain tissue damage during monopolar high-frequency deep brain stimulation
    Brigitte Piallat
    INSERM U836 Université Joseph Fourier Commissariat à l Energie Atomique Centre Hospitalier Universiatire, Grenoble Institute of Neurosciences, Grenoble, France
    Neurosurgery 64:156-62; discussion 162-3. 2009
    ..The aim of the present study was to quantify the evolution of a potentially deleterious effect of HFS according to the duration and/or intensity in monophasic and biphasic conditions...
  80. ncbi What the future holds for deep brain stimulation
    Alim Louis Benabid
    CEA Minatec LETI, Clinatec building 4022, 17 Avenue des Martyrs, 38054, Grenoble, France
    Expert Rev Med Devices 4:895-903. 2007
    ..Technological development will enhance and refine the effects of high-frequency stimulation, and allow further extension of this method to new targets and new indications...
  81. ncbi Surgical pathology of drug-resistant partial epilepsy. A 10-year-experience with a series of 327 consecutive resections
    Basile Pasquier
    Department of Pathology, Centre Hospitalier Universitaire, Hopital Albert Michallon, BP 217, 38043 Grenoble, Cedex 09, France B
    Epileptic Disord 4:99-119. 2002
    ....
  82. ncbi MRI morphological and volumetric study of the cingulate gyrus and its relevance in partial epileptic patients
    Stephane Kremer
    INSERM U318, Department of Neurosciences, University Hospital, Grenoble, 2, France
    Epileptic Disord 5:101-7. 2003
    ..75) or between CG1 + 2 + 3 and normal volunteers (P = 0.83). The volumetric analysis showed no atrophy of the CG in epileptic patients and did not distinguish the group in whom seizures involved the CG, from the other groups...
  83. ncbi Functional neuronal differentiation of bone marrow-derived mesenchymal stem cells
    Philippe Tropel
    Neurosciences Précliniques, INSERM U318, Universite Joseph Fourier, CHU de Grenoble, Grenoble, France
    Stem Cells 24:2868-76. 2006
    ....
  84. ncbi [Therapeutic and physiopathological contribution of electric stimulation of deep brain structures in Parkinson's disease]
    Alim Louis Benabid
    Pavillon B, CHU Albert Michalon 38043 Grenoble
    Bull Acad Natl Med 187:305-19; discussion 319-22. 2003
    ..Moreover the physiopathogenic hypothesis suggests the possibility of a neuroprotective effect of the stimulation, which still needs to be clearly established at the experimental level as well as at the level of clinical applications...
  85. ncbi An algorithm for rapid calculation of a probabilistic functional atlas of subcortical structures from electrophysiological data collected during functional neurosurgery procedures
    Wieslaw L Nowinski
    Institute of Bioengineering, 21 Heng Mui Keng Terrace, Singapore
    Neuroimage 18:143-55. 2003
    ..The key application of the algorithm is targeting in stereotactic and functional neurosurgery, and it also can be employed in human and animal brain research...
  86. ncbi Partial lesion of thalamic ventral intermediate nucleus after chronic high-frequency stimulation
    Jasmine Henderson
    Department of Pharmacology, University of Sydney, NSW, Australia
    Mov Disord 19:709-11. 2004
    ..Post-mortem neuropathology (7 years postoperatively) revealed 60% cell loss within 0.5 mm of the electrode tip. Tremor improvement was attributable to chronic stimulation, not microthalamotomy...
  87. ncbi A probabilistic functional atlas of the VIM nucleus constructed from pre-, intra- and postoperative electrophysiological and neuroimaging data acquired during the surgical treatment of Parkinson's disease patients
    Wieslaw L Nowinski
    Biomedical Imaging Lab, Agency for Science, Technology and Research, Singapore, Singapore
    Stereotact Funct Neurosurg 83:190-6. 2005
    ..The PFA-VIM atlas overcomes several limitations of the current anatomical atlases and can improve targeting of thalamotomies and thalamic stimulations. It is dynamic and can easily be extended with new cases...
  88. ncbi Correlation between the anatomical and functional human subthalamic nucleus
    Wieslaw L Nowinski
    Biomedical Imaging Lab, Agency for Science, Technology and Research, Singapore, Singapore
    Stereotact Funct Neurosurg 85:88-93. 2007
    ..3, >95% of F-STN is inside the A-STN, and for p >or= 0.5, the complete F-STN is inside the A-STN for each left and right STN. Therefore, the F-STN for p = 0.5 can potentially be used for identification of the STN in neuroimages...
  89. ncbi Jean Talairach (1911-2007)
    Alim Louis Benabid
    Stereotact Funct Neurosurg 86:62-3. 2008
  90. ncbi A probabilistic functional atlas of the human subthalamic nucleus
    Wieslaw L Nowinski
    Biomedical Imaging Lab, Institute for Infocomm Research 21 Heng Hui Keng Terrace, Singapore
    Neuroinformatics 2:381-98. 2004
    ..The presented method is general and can be applied for constructing human and animal probabilistic brain atlases...
  91. ncbi Restricted frontomesial epileptogenic focus generating dyskinetic behavior and laughter
    Serge Chassagnon
    Service de Neurologie, Neuropsychologie et Explorations Fonctionnelles des Epilepsies, Hospices Civils de Strasbourg, Strasbourg, France
    Epilepsia 44:859-63. 2003
    ..Substantial data are missing about the anatomic location of frontal regions supporting gelastic seizures...
  92. ncbi From hypothalamic hamartoma to cortex: what can be learnt from depth recordings and stimulation?
    Philippe Kahane
    Neurophysiopathologie de l Epilepsie, CHU de Grenoble, France
    Epileptic Disord 5:205-17. 2003
    ..Whether this proposal of secondary epileptogenesis is valid or not remains a major issue, since it could provide arguments on the moment to discuss surgery...