Research Topics
| A L BenabidSummaryCountry: France Publications
| Collaborators
|
Detail Information
Publications
A putative generalized model of the effects and mechanism of action of high frequency electrical stimulation of the central nervous systemAlim Louis Benabid
INSERM U318, Universite Joseph Fourier, CHU Albert Michallon, Grenoble Cedex 9, France
Acta Neurol Belg 105:149-57. 2005..iv) Retrograde activation of upstream neuronal structures, as reported in the external pallidum during stimulation of STN, might be responsible of additional jamming-like effects due to collisions with descending spikes...- Robotics in neurosurgery: which tools for what?A L Benabid
Neurosurgery and INSERM U318, Department of Neurosciences, Grenoble, France
Acta Neurochir Suppl 98:43-50. 2006..Neurosurgical robots currently available at the operating level are being described. Future evolutions, indications and ethical aspects are examined... - Therapeutic electrical stimulation of the central nervous systemAlim Louis Benabid
INSERM U318, Universite Joseph Fourier, CHU Albert Michallon, pavilion B, BP 217, 38043 Grenoble, France
C R Biol 328:177-86. 2005..The understanding of the mechanism has opened a new field of research, which will call for reappraisal of the basic effects of electricity on the living tissues... - Mechanisms of deep brain stimulationAlim L Benabid
Neurosciences Department, Joseph Fourier University, Centre Hospitalier Universitaire, Grenoble, France
Mov Disord 17:S73-4. 2002..It is clear that the understanding of this strange and powerful phenomenon will profit from both clinical observation and well designed animal experiments... - Antiepileptic effect of high-frequency stimulation of the subthalamic nucleus (corpus luysi) in a case of medically intractable epilepsy caused by focal dysplasia: a 30-month follow-up: technical case reportAlim Louis Benabid
Department of Neurosurgery, University Hospital of Grenoble, and INSERM Research Unit U318, Grenoble, France
Neurosurgery 50:1385-91; discussion 1391-2. 2002..We were encouraged by the known relationship between the STN and the nigral system, as well as by our experience with high-frequency stimulation of the STN in Parkinsonian patients... - Imaging of subthalamic nucleus and ventralis intermedius of the thalamusAlim Louis Benabid
Department of Clinical and Biological Neurosciences, Institut National de la Sante et de la Recherche Medicale, Preclinical Neurosciences U 318, Joseph Fourier University of Grenoble, Hopital A Michallon, France
Mov Disord 17:S123-9. 2002..These shortcomings no doubt will be corrected in the near future, and the technologies will better assist us in the proper placement of electrodes, which will provide the patient with the highest possible benefit... - Deep brain stimulation for Parkinson's diseaseAlim Louis Benabid
INSERM U318 Preclinical Neurosciences, Joseph Fourier University, Pavillon B, University Hospital, 38043, Grenoble, France
Curr Opin Neurobiol 13:696-706. 2003..Long-term changes, neural plasticity and neural protection might be induced in the network. Similar effects of stimulation and lesioning have led to the extension of this technique for other targets and diseases... - Deep brain stimulation of the corpus luysi (subthalamic nucleus) and other targets in Parkinson's disease. Extension to new indications such as dystonia and epilepsyA L Benabid
Department of Neurosurgery, CHU A Michallon, Grenoble, France
J Neurol 248:III37-47. 2001..It is therefore possible that DBS in STN as well as in other targets could become a potent therapeutic tool in the near future for neurological disorders... - Deep-brain stimulation in Parkinson's disease: long-term efficacy and safety - What happened this year?Alim Louis Benabid
INSERM U318 Preclinical Neurosciences and Joseph Fourier Grenoble University, Centre Hospitalier Universitaire Albert Michallon, Grenoble, France
Curr Opin Neurol 18:623-30. 2005..High-frequency stimulation of the subthalamic nucleus has become the surgical therapy of choice. This review concentrates on recent data on long-term results and side-effects, after 12 years of practice using this technique... - Subthalamic stimulation for Parkinson's diseaseA L Benabid
Department of Neurosciences, University Hospital of Grenoble, Grenoble, France
Arch Med Res 31:282-9. 2000..6, 48.6, and 27%, respectively, when compared with the previous preoperative level. From our experience, HFS of the STN could be considered the surgical therapy of choice at advanced stages of Parkinson's disease... - Intrasubthalamic injection of 6-hydroxydopamine induces changes in the firing rate and pattern of subthalamic nucleus neurons in the ratZ Ni
INSERM U.318, Neurobiologie Preclinique, CHU-Pavillon B, BP 217, 38043 Grenoble Cedex 09, France
Synapse 40:145-53. 2001.... - Effect of high-frequency stimulation of the subthalamic nucleus on the neuronal activities of the substantia nigra pars reticulata and ventrolateral nucleus of the thalamus in the ratA Benazzouz
Laboratoire de Neurobiologie Preclinique, INSERM U 318, CHU Pavillon B, BP 217, 38043, Grenoble, France
Neuroscience 99:289-95. 2000..The reduction in tonic inhibitory drive of nigral neurons induces a disinhibition of activity in the ventrolateral motor thalamic nucleus, which should result in activation of the motor cortical system... 
Subthalamic nucleus stimulation in tremor dominant parkinsonian patients with previous thalamic surgeryV Fraix
Department of Neurology, University Hospital of Grenoble, BP 217, 38043 Grenoble Cedex 9, France
J Neurol Neurosurg Psychiatry 76:246-8. 2005..The parkinsonian motor state is greatly improved by bilateral STN stimulation even in patients with previous thalamic surgery, and STN stimulation is more effective than VIM stimulation in tremor dominant parkinsonian patients...
Effects of subthalamic nucleus stimulation and levodopa on freezing of gait in Parkinson diseaseM U Ferraye
Université de Grenoble, INSERM U836, CHU de Grenoble, Pavillon de Neurologie, BP 217, 38043 Grenoble Cedex 9, France
Neurology 70:1431-7. 2008..We studied the effects of subthalamic nucleus (STN) stimulation vs levodopa on freezing of gait (FOG) and gait impairments in a large consecutive series of patients with Parkinson disease with bilateral STN stimulation...- Pedunculopontine nucleus stimulation induces monocular oscillopsiaM U Ferraye
Universite Joseph Fourier, Grenoble, France and INSERM U836, Grenoble Institut des Neurosciences, Grenoble, France
J Neurol Neurosurg Psychiatry 80:228-31. 2009..These results emphasise the difficulty of stimulating this mesencephalic region... - Effect of microiontophoretic application of dopamine on subthalamic nucleus neuronal activity in normal rats and in rats with unilateral lesion of the nigrostriatal pathwayZ Ni
, INSERM U.318, CHU, Pavillon B, B.P. 217, 38043 Grenoble Cedex 09, France
Eur J Neurosci 14:373-81. 2001.... - Subthalamic nucleus versus pedunculopontine nucleus stimulation in Parkinson disease: synergy or antagonism?M U Ferraye
University J Fourier Grenoble 1, 38041, Grenoble, France
J Neural Transm 118:1469-75. 2011.... - Implication of the subthalamic nucleus in the pathophysiology and pathogenesis of Parkinson's diseaseA Benazzouz
Laboratoire de Neurobiologie Preclinique, INSERM U 318, Grenoble, France
Cell Transplant 9:215-21. 2000..The evidence reviewed in the present article clearly demonstrates that the STN is implicated in the pathophysiology and pathogenesis of Parkinson's disease... - Ineffective subthalamic nucleus stimulation in levodopa-resistant postischemic parkinsonismP Krack
Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France
Neurology 54:2182-4. 2000..This case suggests that parkinsonian patients who do not have a good response to levodopa or in whom a postsynaptic dopaminergic lesion can be shown may not be good candidates for STN surgery... - Is there a role for physiotherapy during deep brain stimulation surgery in patients with Parkinson's disease?E Chevrier
Department of Neurology, Movement Disorders Unit, Grenoble University Hospital, Grenoble, Cedex 09, France
Eur J Neurol 13:496-8. 2006..All patients except one experienced physical pain and psychological suffering, alleviated by physiotherapy. These preliminary results need to be confirmed in a prospective randomized study... - Functional neurosurgery: past, present, and futureA L Benabid
University Joseph Fourier, Grenoble, France
Clin Neurosurg 52:265-70. 2005 - High frequency deep brain stimulation of the subthalamic nucleus versus continuous subcutaneous apomorphine infusion therapy: a reviewR Carron
Department of Neurosurgery, University Hospital, Grenoble, France
J Neural Transm 118:915-24. 2011.... - Time-course of changes in firing rates and firing patterns of subthalamic nucleus neuronal activity after 6-OHDA-induced dopamine depletion in ratsZ G Ni
, INSERM U. 318, CHU - Pavillon B, B.P. 217, 38043 Cedex 09, Grenoble, France
Brain Res 899:142-7. 2001.... - Pyramidal tract side effects induced by deep brain stimulation of the subthalamic nucleusG Tommasi
Department of Neurology, University Hospital, Joseph Fourier University, Grenoble, France
J Neurol Neurosurg Psychiatry 79:813-9. 2008..To study the pyramidal tract side effects (PTSEs) induced by the spread of current from the subthalamic nucleus (STN) to the pyramidal tract (PT), in patients with parkinsonism undergoing STN stimulation... - Effect of bilateral subthalamic nucleus stimulation on parkinsonian gaitJ Xie
Department of Clinical and Biological Neurosciences, Centre Hospitalier Universitaire de Grenoble, France
J Neurol 248:1068-72. 2001..The UPDRS motor score was significantly (p < 0.001) decreased after both stimulation and levodopa. In conclusion, STN stimulation is effective on parkinsonian gait... - Unilateral lesion of the nigrostriatal pathway induces an increase of neuronal activity of the pedunculopontine nucleus, which is reversed by the lesion of the subthalamic nucleus in the ratS Breit
INSERM U318, Laboratoire de Neuroscience Preclinique, CHU-Pavillon B, BP 217, 38043 Grenoble Cedex 09, France
Eur J Neurosci 14:1833-42. 2001.... - Mirthful laughter induced by subthalamic nucleus stimulationP Krack
Neuroscience Department, University of Grenoble, Grenoble, France
Mov Disord 16:867-75. 2001..Our report suggests that the STN, with its sensorimotor, cognitive, and limbic parts is not only involved in motor, but also in psychomotor regulation... - Contribution of dynamic contrast MR imaging to the differentiation between dural metastasis and meningiomaS Kremer
Neuroradiology Department, University Hospital, Nancy, France
Neuroradiology 46:642-8. 2004..To determine the perfusion-sensitive characteristics of cerebral dural metastases and compare them with the data on meningiomas... - Pretargeting for the implantation of stimulation electrodes into the subthalamic nucleus: a comparative study of magnetic resonance imaging and ventriculographySorin Breit
INSERM U 318, Department of Neurobiology, University Joseph Fourier, Grenoble, France
Neurosurgery 58:ONS83-95. 2006..The purpose of this study was to evaluate the accuracy of the preoperative MRI targeting as compared with ventriculography in terms of both the STN target as well as the internal landmarks... - Intraoperative microrecordings of the subthalamic nucleus in Parkinson's diseaseAbdelhamid Benazzouz
Department of Clinical and Biological Neurosciences, Institut National de la Santé et de la Recherche Médicale U 318, University Hospital A Michallon, Pavillon B, Grenoble, France
Mov Disord 17:S145-9. 2002..In conclusion, microelectrode recording of the subthalamic area improves the accuracy of targeting the STN... - Deep brain stimulation of the subthalamic nucleus in Parkinson's disease 1993-2003: where are we 10 years on?K Ashkan
Department of Clinical Neurosciences, University of Joseph Fourier, Grenoble, France
Br J Neurosurg 18:19-34. 2004..The evolution of the surgical technique and long-term patients' outcome are further discussed... - Bilateral subthalamic nucleus stimulation improves health-related quality of life in PDE Lagrange
Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France
Neurology 59:1976-8. 2002..All aspects of quality of life, including motor (+48%), systemic (+34%), emotional (+29%), and social (+63%) dimensions, significantly improved with long-term STN stimulation... - Effects of levodopa and subthalamic nucleus stimulation on cognitive and affective functioning in Parkinson's diseaseAurélie Funkiewiez
Department of Clinical and Biological Neurosciences, University Hospital of Grenoble, and INSERM U318, Joseph Fourier University of Grenoble, Grenoble, France
Mov Disord 21:1656-62. 2006..To conclude, there were significant but contrasting effects of levodopa and STN stimulation on cognition and affective functions... - Effect of bilateral stimulation of the subthalamic nucleus on parkinsonian voiceM Gentil
INSERM, Unité 318, Centre Hospitalier Universitaire de Grenoble, Grenoble, France
Brain Lang 78:233-40. 2001..Relative intensity was unchanged in both conditions. Further acoustic analyses are warranted to clarify the role of STN stimulation on parkinsonian speech... - Comparison of two techniques to postoperatively localize the electrode contacts used for subthalamic nucleus stimulationSerge Pinto
Department of Neurology, Centre Hospitalier Universitaire de Grenoble, and INSERM U318, Neurosciences Précliniques, Grenoble, France
Neurosurgery 60:285-92; discussion 292-4. 2007..To our knowledge, this is the first study attempting to compare the "gold standard" of stereotactic accuracy (Vg) with the anatomic resolution provided by MRI scans... - Middle short gyrus of the insula implicated in pain processingAfif Afif
Neurosurgery Department, INSERM U318, Grenoble University Hospital, BP 217, 38043 Grenoble Cedex 9, France
Pain 138:546-55. 2008..All sites inducing painful sensations were restricted to the upper portion of the middle short gyrus of the insula. The findings of this study suggest that middle short gyrus is involved in the processing of pain-producing stimuli... - Improvement in Parkinson disease by subthalamic nucleus stimulation based on electrode placement: effects of reimplantationMathieu Anheim
Department of Neurology, University Hospital A Michallon, Grenoble, France
Arch Neurol 65:612-6. 2008..The misplacement of electrodes is a possible explanation for suboptimal response to bilateral subthalamic nucleus (STN) stimulation in patients with Parkinson disease... - Response to levodopa in parkinsonian patients with bilateral subthalamic nucleus stimulationElena Moro
Department of Clinical and Biological Neurosciences and INSERM U318, Joseph Fourier University, CHU de Grenoble, Grenoble, France
Brain 125:2408-17. 2002..In addition, the persistence of levodopa intake after surgery might hinder this beneficial process... - Muscle transfection by electroporation with high-voltage and short-pulse currents provides high-level and long-lasting gene expressionJ M Vicat
INSERM U 318, Laboratoire de Neurobiophysique UJFG, Centre Hospitalier Universitaire, Grenoble, France
Hum Gene Ther 11:909-16. 2000..In conclusion, electroporation with high-voltage and short-pulse currents provides high-level and long-lasting gene expression in muscle... - Effects of 6-hydroxydopamine-induced severe or partial lesion of the nigrostriatal pathway on the neuronal activity of pallido-subthalamic network in the ratS Breit
INSERM U 318, Department of Preclinical Neurobiology, Joseph Fourier University, Grenoble, France
Exp Neurol 205:36-47. 2007..These data suggest that in the GP-STN-GP network, the excitatory influence of the STN-GP pathway overrides that of the GABAergic GP-STN pathway, questioning the classical model of basal ganglia organization... - [Deep brain stimulation]V Fraix
Departement de Neurologie, Centre Hospitalier Universitaire de Grenoble, Grenoble
Rev Neurol (Paris) 160:511-21. 2004..Such studies, including cost benefit studies would be useful to assess the respective value of these different techniques... - Effect of stimulation of the subthalamic nucleus on oral control of patients with parkinsonismM Gentil
INSERM, Unit 318, CHU Grenoble, France
J Neurol Neurosurg Psychiatry 67:329-33. 1999..To assess the oral system of parkinsonian patients treated with chronic stimulation of the bilateral subthalamic nucleus (STN) to evaluate precisely the effectiveness of this procedure on the articulatory organs... - Effect of bilateral deep-brain stimulation on oral control of patients with parkinsonismM Gentil
INSERM Unit 318, CHU Grenoble, France
Eur Neurol 44:147-52. 2000..The target of stimulation differently influences the oral system and modulates neuronal structures involved in speech... - Effects of subthalamic nucleus stimulation on motor cortex excitability in Parkinson's diseaseValerie Fraix
Department of Neurology, University Hospital of Grenoble and INSERM U836, Joseph Fourier University, 38000 Grenoble, France
Clin Neurophysiol 119:2513-8. 2008..To study the effects of subthalamic nucleus (STN) stimulation on motor cortex excitability in Parkinson's disease (PD)... - Coordinated and spatial upregulation of arc in striatonigral neurons correlates with L-dopa-induced behavioral sensitization in dyskinetic ratsVéronique Sgambato-Faure
INSERM U318, Laboratoire de Neurosciences Précliniques, CHU Pavillon B, Grenoble, France
J Neuropathol Exp Neurol 64:936-47. 2005.... - Functional neurosurgery for movement disorders: a historical perspectiveAlim Louis Benabid
CEA Minatec LETI and INSERM, Joseph Fourier University, Grenoble, France
Prog Brain Res 175:379-91. 2009..The new field of compensation of deficits will then become part of the field of functional neurosurgery... - Filtering out deep brain stimulation artifacts using a nonlinear oscillatory modelTatyana I Aksenova
Unit 318, INSERM, 38043 Grenoble, Cedex 09, France, and Institute of Applied System Analysis, Ukrainian Academy of Sciences, Kiev 03056, Ukraine
Neural Comput 21:2648-66. 2009..The proposed algorithm was tested using recordings collected from patients during the stimulation. This was then compared to existing methods and showed the best performance... - De novo and long-term l-Dopa induce both common and distinct striatal gene profiles in the hemiparkinsonian ratMichele El Atifi-Borel
Institut National de la Sante et de la Recherche Medicale, Grenoble, France
Neurobiol Dis 34:340-50. 2009..Processes such as growth, synaptogenesis, neurogenesis and cell proliferation may be particularly relevant to the long-term action of l-Dopa... - Survival of midbrain dopaminergic cells after lesion or deep brain stimulation of the subthalamic nucleus in MPTP-treated monkeysBradley A Wallace
Department of Clinical and INSERM U318 Preclinical Neurosciences, University Joseph Fourier, Grenoble, France
Brain 130:2129-45. 2007..In summary, these results indicated that STN alteration offered neuroprotection to dopaminergic cells that would normally die as part of the disease process... - Unsupervised Spike Sorting of extracellular electrophysiological recording in subthalamic nucleus of Parkinsonian patientsOlga K Chibirova
Laboratory of Preclinical Neuroscience INSERM U318 CHUG Michallon Pavillon B BP 217 F 38043 Grenoble Cedex 9 France
Biosystems 79:159-71. 2005..We analyzed separately two brain hemispheres. For each hemisphere the percentage of units of each activity pattern were calculated. The results were compared for the first and the second operated hemispheres of each patient and in total... - Five-year follow-up of bilateral stimulation of the subthalamic nucleus in advanced Parkinson's diseasePaul Krack
Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France
N Engl J Med 349:1925-34. 2003..Although the short-term benefits of bilateral stimulation of the subthalamic nucleus in patients with advanced Parkinson's disease have been well documented, the long-term outcomes of the procedure are unknown... - The role of the temporal pole in the genesis of temporal lobe seizuresPhilippe Kahane
Neurophysiopathology of the Epilepsy, Grenoble University Hospital, Grenoble, France
Epileptic Disord 4:S51-8. 2002..However a clear-cut distinction between the two groups remains rather difficult in the absence of intracerebral recordings... - An unsupervised automatic method for sorting neuronal spike waveforms in awake and freely moving animalsTetyana I Aksenova
Institute of Applied System Analysis, Ukrainian Academy of Sciences, Prospekt Peremogy 37, 03056 Kiev, Ukraine
Methods 30:178-87. 2003..The new method of spike sorting was tested on simulated and real data and performed better than other approaches currently used in neurophysiology... - Postoperative management of subthalamic nucleus stimulation for Parkinson's diseasePaul Krack
Department of Clinical and Biological Neurosciences, Service de Neurologie, Centre Hospitalier Universitaire de Grenoble, Grenoble, France
Mov Disord 17:S188-97. 2002..Neurosurgeons who perform DBS need to understand the principles that guide the postoperative adaptation of treatment. This article defines guidelines for setting stimulation parameters, adapting drugs and managing adverse effects... - Intraoperative micro- and macrostimulation of the subthalamic nucleus in Parkinson's diseasePierre Pollak
Department of Clinical and Biological Neurosciences, Service de Neurologie, Centre Hospitalier Universitaire de Grenoble, Grenoble, France
Mov Disord 17:S155-61. 2002..New skills are needed to assess all stimulation-induced effects and interpret them in anatomo-functional terms... - Treatment results: Parkinson's diseasePierre Pollak
Department of Clinical and Biological Neurosciences, Service de Neurologie, Centre Hospitalier Universitaire de Grenoble, France
Mov Disord 17:S75-83. 2002..Intracranial electrode implantation can induce a hematoma or contusion. Most authors agree that the benefit to risk ratio of DBS is favorable... - Bilateral subthalamic stimulation effects on oral force control in Parkinson's diseaseSerge Pinto
Service de Neurologie, CHU de Grenoble, BP 217, 38043 Grenoble Cedex 09, France
J Neurol 250:179-87. 2003..Nevertheless, to confirm the persistence of the beneficial effect of STN stimulation on parkinsonian dysarthria, a longitudinal evaluation is still needed... - Effect of bilateral stimulation of the subthalamic nucleus on parkinsonian dysarthriaMichèle Gentil
INSERM, Unit 318, CHU, Service neurologie, BP 217 38043, Grenoble Cedex 9, France
Brain Lang 85:190-6. 2003..We also noted a large beneficial effect on voice with a significant improvement in respiratory and phonatory functions... - Body fat and body weight reduction following hypothalamic deep brain stimulation in monkeys: an intraventricular approachN Torres
1 Unite INSERM, U836 UJFG, GIN, France 2 CEA LETI CLINATEC, Minatec Campus, Grenoble, France
Int J Obes (Lond) 36:1537-44. 2012..No significant adverse effects were recorded.Conclusion:The stimulation of the VMH region through an intraventricular approach might acutely modulate FI and induce a sustained decrease in BW and fat mass in normal non-human primate... - Microarray RNA quantification assay for large-scale nanosamples analysisI Dupre
Laboratoire de Neurosciences Précliniques, INSERM U318, Universite J Fourier, CHR Grenoble, France
Biotechniques 31:856-8, 860. 2001..Furthermore, with this procedure, the reproducibility, sensitivity, and accuracy of the assay are notably improved as compared to current methods... - Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's diseaseD Blum
Unité Mixte INSERM UJF E0108, Neurodégénérescence et Plasticité, CHU Michallon, Pavillon de Neurologie, BP217, 38043 Cedex 9, Grenoble, France
Prog Neurobiol 65:135-72. 2001..This review reports recent data concerning the biochemical and molecular apoptotic mechanisms underlying the experimental models of PD and correlates them to the phenomena occurring in human disease... - The temporopolar cortex plays a pivotal role in temporal lobe seizuresStephan Chabardes
Department of Neurosurgery, CHU Michallon, Grenoble, France
Brain 128:1818-31. 2005..Moreover, the involvement of the TP cortex at the onset of the seizures is a good predicting factor for postoperative seizure outcome... - Deep brain stimulation of the subthalamic nucleus for the treatment of Parkinson's diseaseAlim Louis Benabid
Department of Neurosurgery and Neurology, University of Grenoble, CHU Albert Michallon, Grenoble, France
Lancet Neurol 8:67-81. 2009..Further improvements, through basic research and methodological innovations, should make it applicable to earlier stages of the disease and increase its availability to patients in developing countries... - Changes induced by levodopa and subthalamic nucleus stimulation on parkinsonian speechSerge Pinto
Neurosciences Précliniques, INSERM Unité 318, Grenoble, France
Mov Disord 20:1507-15. 2005..These hypotheses may be helpful for better understanding and management of STN stimulation effects on motor speech and skeleton-motor subsystems... - Lifetime of Itrel II pulse generators for subthalamic nucleus stimulation in Parkinson's diseaseMathieu Anheim
Department of Neurology, University Hospital A Michallon, Grenoble, France
Mov Disord 22:2436-9. 2007..A close monitoring of patients and an anticipation of IPG replacement in the case of a low-battery signal are recommended... - The impact on Parkinson's disease of electrical parameter settings in STN stimulationE Moro
Department of Clinical and Biological Neurosciences and INSERM U318, Joseph Fourier University, CHU de Grenoble, France
Neurology 59:706-13. 2002..The mechanisms by which STN DBS improves parkinsonism remain speculative... - Chemoarchitectonic heterogeneities in the primate zona incerta: clinical and functional implicationsJohn Mitrofanis
Department of Clinical Neurosciences, University of Joseph Fourier, Grenoble, France
J Neurocytol 33:429-40. 2004..Such clinical stimulations could well involve other systems, including those of arousal, attention and visceral control... - Effects of pulse width variations in pallidal stimulation for primary generalized dystoniaLaurent Vercueil
Neurology and Neurosurgery, CHU Grenoble, 38043 Grenoble, France
J Neurol 254:1533-7. 2007..Various pulse widths (from 60-450 mus) have been used for bilateral pallidal stimulation in generalized dystonia but, to date, no comparison of this parameter's effects is available... - Subthalamic nucleus stimulation and dysarthria in Parkinson's disease: a PET studySerge Pinto
INSERM U318, Grenoble, France
Brain 127:602-15. 2004..STN stimulation tends to reverse these abnormal activations, which is consistent with the observed improvement of Parkinson's disease dysarthria... - Dynamic contrast-enhanced MRI: differentiating melanoma and renal carcinoma metastases from high-grade astrocytomas and other metastasesS Kremer
INSERM U318, Centre Hospitalier et Universitaire de Grenoble, , 38043 Grenoble Cedex 09, France
Neuroradiology 45:44-9. 2003..59). Large, solitary, necrotic metastases can be indistinguishable from high-grade astrocytomas using conventional MRI. Demonstration of an elevated rCBV which may suggest a hypervascular lesion such as renal carcinoma or melanoma... - The bacterial nucleoside N(6)-methyldeoxyadenosine induces the differentiation of mammalian tumor cellsD Ratel
INSERM U318, CHU Michallon, 38033 Grenoble cedex 9, France
Biochem Biophys Res Commun 285:800-5. 2001..Furthermore, the finding that a methylated nucleoside found in bacterial DNA induces a biological process might have implications in gene therapy approaches when plasmid DNAs are injected into humans... - Quantification of DNA probes on nylon microarrays using T4 polynucleotide kinase labelingM el Atifi
CHRU, Equipe Transcriptome, Grenoble, France
Biotechniques 35:262-4, 266. 2003 - Rationale for hypothalamus-deep brain stimulation in food intake disorders and obesityN Torres
CEA CLINATEC, Grenoble, France
Adv Tech Stand Neurosurg 36:17-30. 2011..All those elements have made possible the recent regain of interest in DBS for morbid obesity and open an exciting new area of research in neurosurgery and endocrinology... - Long oligonucleotide arrays on nylon for large-scale gene expression analysisM el Atifi
CHRU, Equipe Transcriptome, INSERM U318, Laboratoire de Neurosciences Précliniques, Grenoble, France
Biotechniques 33:612-6, 618. 2002..The long oligonucleotide array thus provides a very convenient method for the analysis of gene expression patterns in biological specimens and in clinical research... - What the future holds for deep brain stimulationAlim Louis Benabid
CEA Minatec LETI, Clinatec building 4022, 17 Avenue des Martyrs, 38054, Grenoble, France
Expert Rev Med Devices 4:895-903. 2007..Technological development will enhance and refine the effects of high-frequency stimulation, and allow further extension of this method to new targets and new indications... - Surgical pathology of drug-resistant partial epilepsy. A 10-year-experience with a series of 327 consecutive resectionsBasile Pasquier
Department of Pathology, Centre Hospitalier Universitaire, Hopital Albert Michallon, BP 217, 38043 Grenoble, Cedex 09, France B
Epileptic Disord 4:99-119. 2002.... - Monophasic but not biphasic pulses induce brain tissue damage during monopolar high-frequency deep brain stimulationBrigitte Piallat
INSERM U836 Université Joseph Fourier Commissariat à l Energie Atomique Centre Hospitalier Universiatire, Grenoble Institute of Neurosciences, Grenoble, France
Neurosurgery 64:156-62; discussion 162-3. 2009..The aim of the present study was to quantify the evolution of a potentially deleterious effect of HFS according to the duration and/or intensity in monophasic and biphasic conditions... - MRI morphological and volumetric study of the cingulate gyrus and its relevance in partial epileptic patientsStephane Kremer
INSERM U318, Department of Neurosciences, University Hospital, Grenoble, 2, France
Epileptic Disord 5:101-7. 2003..75) or between CG1 + 2 + 3 and normal volunteers (P = 0.83). The volumetric analysis showed no atrophy of the CG in epileptic patients and did not distinguish the group in whom seizures involved the CG, from the other groups... - Functional neuronal differentiation of bone marrow-derived mesenchymal stem cellsPhilippe Tropel
Neurosciences Précliniques, INSERM U318, Universite Joseph Fourier, CHU de Grenoble, Grenoble, France
Stem Cells 24:2868-76. 2006.... - Partial lesion of thalamic ventral intermediate nucleus after chronic high-frequency stimulationJasmine Henderson
Department of Pharmacology, University of Sydney, NSW, Australia
Mov Disord 19:709-11. 2004..Post-mortem neuropathology (7 years postoperatively) revealed 60% cell loss within 0.5 mm of the electrode tip. Tremor improvement was attributable to chronic stimulation, not microthalamotomy... - An algorithm for rapid calculation of a probabilistic functional atlas of subcortical structures from electrophysiological data collected during functional neurosurgery proceduresWieslaw L Nowinski
Institute of Bioengineering, 21 Heng Mui Keng Terrace, Singapore
Neuroimage 18:143-55. 2003..The key application of the algorithm is targeting in stereotactic and functional neurosurgery, and it also can be employed in human and animal brain research... - A probabilistic functional atlas of the VIM nucleus constructed from pre-, intra- and postoperative electrophysiological and neuroimaging data acquired during the surgical treatment of Parkinson's disease patientsWieslaw L Nowinski
Biomedical Imaging Lab, Agency for Science, Technology and Research, Singapore, Singapore
Stereotact Funct Neurosurg 83:190-6. 2005..The PFA-VIM atlas overcomes several limitations of the current anatomical atlases and can improve targeting of thalamotomies and thalamic stimulations. It is dynamic and can easily be extended with new cases... - [Therapeutic and physiopathological contribution of electric stimulation of deep brain structures in Parkinson's disease]Alim Louis Benabid
Pavillon B, CHU Albert Michalon-38043 Grenoble
Bull Acad Natl Med 187:305-19; discussion 319-22. 2003..Moreover the physiopathogenic hypothesis suggests the possibility of a neuroprotective effect of the stimulation, which still needs to be clearly established at the experimental level as well as at the level of clinical applications... - Jean Talairach (1911-2007)Alim Louis Benabid
Stereotact Funct Neurosurg 86:62-3. 2008 - Correlation between the anatomical and functional human subthalamic nucleusWieslaw L Nowinski
Biomedical Imaging Lab, Agency for Science, Technology and Research, Singapore, Singapore
Stereotact Funct Neurosurg 85:88-93. 2007..3, >95% of F-STN is inside the A-STN, and for p >or= 0.5, the complete F-STN is inside the A-STN for each left and right STN. Therefore, the F-STN for p = 0.5 can potentially be used for identification of the STN in neuroimages... - From hypothalamic hamartoma to cortex: what can be learnt from depth recordings and stimulation?Philippe Kahane
Neurophysiopathologie de l Epilepsie, CHU de Grenoble, France
Epileptic Disord 5:205-17. 2003..Whether this proposal of secondary epileptogenesis is valid or not remains a major issue, since it could provide arguments on the moment to discuss surgery... - A probabilistic functional atlas of the human subthalamic nucleusWieslaw L Nowinski
Biomedical Imaging Lab, Institute for Infocomm Research 21 Heng Hui Keng Terrace, Singapore
Neuroinformatics 2:381-98. 2004..The presented method is general and can be applied for constructing human and animal probabilistic brain atlases... - Restricted frontomesial epileptogenic focus generating dyskinetic behavior and laughterSerge Chassagnon
Service de Neurologie, , Hospices Civils de Strasbourg, Strasbourg, France
Epilepsia 44:859-63. 2003..In this case, the coexistence of paroxysmal dyskinesias during laughter might reflect the involvement of specific compartment(s) of the basal ganglia...