Yehezkel Ben-Ari

Summary

Country: France

Publications

  1. doi Excitatory GABA in rodent developing neocortex in vitro
    Sylvain Rheims
    Institut de Neurobiologie de la Mediterranee, Institut National de la Sante et de la Recherche Medicale U901, Universite de la Mediterranee, route de Luminy, Marseille, France
    J Neurophysiol 100:609-19. 2008
  2. ncbi The GABA excitatory/inhibitory shift in brain maturation and neurological disorders
    Yehezkel Ben-Ari
    INMED, INSERM unit 901 and Neurochlore, Marseille, France
    Neuroscientist 18:467-86. 2012
  3. ncbi Developing networks play a similar melody
    Y Ben-Ari
    INMED, INSERM U29, Avenue de Luminy, B P 13, 13273 Cedex 09, Marseille, France
    Trends Neurosci 24:353-60. 2001
  4. ncbi Seizures beget seizures: the quest for GABA as a key player
    Yehezkel Ben-Ari
    INMED, INSERM U 29, Parc Scientifique etTechnologique de Luminy, Marseille, France
    Crit Rev Neurobiol 18:135-44. 2006
  5. pmc Phenotypic checkpoints regulate neuronal development
    Yehezkel Ben-Ari
    Institut de Neurobiologie de la Méditerranée INMED, Institut National de la Santé et de la Recherche Médicale INSERM Unité 901, Parc Scientifique de Luminy, Marseille Cedex 09, France
    Trends Neurosci 33:485-92. 2010
  6. pmc Epilepsies and neuronal plasticity: for better or for worse?
    Yehezkel Ben-Ari
    French Medical Research Council, INSERM U29 INMED, Marseille, France
    Dialogues Clin Neurosci 10:17-27. 2008
  7. ncbi Basic developmental rules and their implications for epilepsy in the immature brain
    Yehezkel Ben-Ari
    INMED INSERM, Parc Scientifique de Luminy, Marseille, France
    Epileptic Disord 8:91-102. 2006
  8. doi Neuro-archaeology: pre-symptomatic architecture and signature of neurological disorders
    Yehezkel Ben-Ari
    Institute of Neurobiology of the Mediterranean Sea INMED, Institut National de la Sante et de la Recherche Medicale INSERM, Campus Scientifique de Luminy, route de Luminy, Marseille 13263 Cedex, France
    Trends Neurosci 31:626-36. 2008
  9. ncbi Interneurons set the tune of developing networks
    Yehezkel Ben-Ari
    Institut de Neurobiologie de la Méditerranée INMED, Parc Scientifique de Luminy, BP13, 13009 Marseille, France
    Trends Neurosci 27:422-7. 2004
  10. ncbi The multiple facets of gamma-aminobutyric acid dysfunction in epilepsy
    Yehezkel Ben-Ari
    Institut de Neurobiologie de le Méditerranée, INSERM, Parc Scientifique de Luminy, Marseilles, France
    Curr Opin Neurol 18:141-5. 2005

Collaborators

Detail Information

Publications74

  1. doi Excitatory GABA in rodent developing neocortex in vitro
    Sylvain Rheims
    Institut de Neurobiologie de la Mediterranee, Institut National de la Sante et de la Recherche Medicale U901, Universite de la Mediterranee, route de Luminy, Marseille, France
    J Neurophysiol 100:609-19. 2008
    ..In the companion paper, we show that the excitatory GABA drives layer-specific seizures in the immature neocortex...
  2. ncbi The GABA excitatory/inhibitory shift in brain maturation and neurological disorders
    Yehezkel Ben-Ari
    INMED, INSERM unit 901 and Neurochlore, Marseille, France
    Neuroscientist 18:467-86. 2012
    ....
  3. ncbi Developing networks play a similar melody
    Y Ben-Ari
    INMED, INSERM U29, Avenue de Luminy, B P 13, 13273 Cedex 09, Marseille, France
    Trends Neurosci 24:353-60. 2001
    ....
  4. ncbi Seizures beget seizures: the quest for GABA as a key player
    Yehezkel Ben-Ari
    INMED, INSERM U 29, Parc Scientifique etTechnologique de Luminy, Marseille, France
    Crit Rev Neurobiol 18:135-44. 2006
    ..Therefore, GABA-receptor antagonists are pro-convulsive in the developing brain but, in fact, anti-epileptic. This paradoxical conclusion has quite a few clinical implications that are discussed...
  5. pmc Phenotypic checkpoints regulate neuronal development
    Yehezkel Ben-Ari
    Institut de Neurobiologie de la Méditerranée INMED, Institut National de la Santé et de la Recherche Médicale INSERM Unité 901, Parc Scientifique de Luminy, Marseille Cedex 09, France
    Trends Neurosci 33:485-92. 2010
    ..Such checkpoints are likely to be a general feature of neuronal development and constitute presymptomatic signatures of neurological disorders when they go awry...
  6. pmc Epilepsies and neuronal plasticity: for better or for worse?
    Yehezkel Ben-Ari
    French Medical Research Council, INSERM U29 INMED, Marseille, France
    Dialogues Clin Neurosci 10:17-27. 2008
    ..Reactive plasticity is documented for other insults and disorders, and may be the basis for the long-term progression of neurodegenerative disorders...
  7. ncbi Basic developmental rules and their implications for epilepsy in the immature brain
    Yehezkel Ben-Ari
    INMED INSERM, Parc Scientifique de Luminy, Marseille, France
    Epileptic Disord 8:91-102. 2006
    ..To facilitate teaching purposes the paper is published together with supplemental data (as a PowerPoint presentation included in the accompanying DVD), thus allowing an overview of important developmental steps and their implications...
  8. doi Neuro-archaeology: pre-symptomatic architecture and signature of neurological disorders
    Yehezkel Ben-Ari
    Institute of Neurobiology of the Mediterranean Sea INMED, Institut National de la Sante et de la Recherche Medicale INSERM, Campus Scientifique de Luminy, route de Luminy, Marseille 13263 Cedex, France
    Trends Neurosci 31:626-36. 2008
    ..The core of this working hypothesis is that imaging or non-invasive recordings might unravel signatures of disorders to come, thereby permitting earlier diagnosis and potential treatment of neurological disorders...
  9. ncbi Interneurons set the tune of developing networks
    Yehezkel Ben-Ari
    Institut de Neurobiologie de la Méditerranée INMED, Parc Scientifique de Luminy, BP13, 13009 Marseille, France
    Trends Neurosci 27:422-7. 2004
    ..This review discusses this sequence of events, its functional significance and the role that interneurons might play in the construction of cortical networks...
  10. ncbi The multiple facets of gamma-aminobutyric acid dysfunction in epilepsy
    Yehezkel Ben-Ari
    Institut de Neurobiologie de le Méditerranée, INSERM, Parc Scientifique de Luminy, Marseilles, France
    Curr Opin Neurol 18:141-5. 2005
    ..This review deals with recent observations concerning the mechanisms and clinical implications of the shift in GABA's activity from inhibition to excitation...
  11. doi [Relevance of basic research to clinical data: Good answers, wrong questions!]
    Y Ben-Ari
    INSERM U29, Institut de Neurobiologie de la Méditerranée INMED, Parc Scientifique de Luminy, B P 13, 13273 Marseille Cedex 09, France
    Neurochirurgie 54:123-7. 2008
    ..In conclusion, it is suggested that although animal data cannot mimic human seizures in all their complex and variable etiologies, it provides essential indications on the mechanisms that enable seizure generation...
  12. ncbi Effects of seizures on developmental processes in the immature brain
    Yehezkel Ben-Ari
    Institute of Neurobiology of the Mediterranean Sea INMED, INSERM and Université de la Méditerranée, Marseilles, France
    Lancet Neurol 5:1055-63. 2006
    ..In this Review, we present basic developmental principles obtained from animal studies and examine the long-lasting consequences of epilepsy...
  13. doi Excitatory action of GABA on immature neurons is not due to absence of ketone bodies metabolites or other energy substrates
    Yehezkel Ben-Ari
    INMED, INSERM U901, Marseille, France
    Epilepsia 52:1544-58. 2011
    ....
  14. ncbi Excitatory actions of gaba during development: the nature of the nurture
    Yehezkel Ben-Ari
    Institut de Neurobiologie de la Méditerranée INMED, INSERM Unit 29, Parc Scientifique de Luminy, 13273 Marseille Cedex 09, France
    Nat Rev Neurosci 3:728-39. 2002
    ..As key elements of this cascade are activity dependent, the formation of inhibition adds an element of nurture to the construction of cortical networks...
  15. ncbi [GABA, a key transmitter for fetal brain maturation]
    Yehezkel Ben-Ari
    INMED, INSERM U29, Parc Scientifique et Technologique de Luminy, 163, route de Luminy, 13273, Marseille Cedex 9, France
    Med Sci (Paris) 23:751-5. 2007
    ..These observations have important clinical implications in relation to delivery associated insults but also preterm delivery and more generally consumption of agents during gestation...
  16. ncbi GABA: a pioneer transmitter that excites immature neurons and generates primitive oscillations
    Yehezkel Ben-Ari
    Insititut de Neurobiologie de la Méditerranée, Institut National de la Santé et de la Recherche Médicale U 29, Marseille, France
    Physiol Rev 87:1215-84. 2007
    ..In conclusion, it is suggested that an evolutionary preserved role for excitatory GABA in immature cells provides an important mechanism in the formation of synapses and activity in neuronal networks...
  17. ncbi Cell death and synaptic reorganizations produced by seizures
    Y Ben-Ari
    Institut de Neurobiologie de la Méditerranée INMED, INSERM U29, route de Luminy, 13273 Marseille, France
    Epilepsia 42:5-7. 2001
    ..It is therefore essential to develop novel strategies based on the unique mode of operation of the mature epileptic circuit, rather than on acute models of epilepsy...
  18. ncbi A noncanonical release of GABA and glutamate modulates neuronal migration
    Jean Bernard Manent
    Institut de Neurobiologie de la Mediterranee, Institut National de la Santé et de la Recherche Médicale U29, Campus de Luminy BP13, 13273 Marseille, France
    J Neurosci 25:4755-65. 2005
    ..We conclude that GABA and, to a lesser degree, glutamate released in a SNARE-independent mechanism exert a paracrine action on neuronal migration...
  19. doi Abnormal network activity in a targeted genetic model of human double cortex
    James B Ackman
    INMED, INSERM, Universite de la Mediterranee, Marseille, France
    J Neurosci 29:313-27. 2009
    ..We suggest that this duality play a major role in cortical dysfunction of DCX brains...
  20. ncbi Maternal oxytocin triggers a transient inhibitory switch in GABA signaling in the fetal brain during delivery
    Roman Tyzio
    Institut de Neurobiologie de la Mediterranee, INSERM U29, Universite de la Mediterranee, Campus Scientifique de Luminy, Boite Postale 13, 13273 Marseille Cedex 09, France
    Science 314:1788-92. 2006
    ..Thus, maternal oxytocin inhibits fetal neurons and increases their resistance to insults during delivery...
  21. ncbi Interneurons targeting similar layers receive synaptic inputs with similar kinetics
    Rosa Cossart
    INMED, INSERM U29, Parc Scientifique de Luminy, B P 13, 13673 Marseille, Cedex 9, France
    Hippocampus 16:408-20. 2006
    ....
  22. ncbi Network mechanisms of spindle-burst oscillations in the neonatal rat barrel cortex in vivo
    Marat Minlebaev
    The Mediterranean Institute of Neurobiology INSERM U29, 163 Avenue de Luminy, B P 13, 13273 Marseille, France
    J Neurophysiol 97:692-700. 2007
    ..We propose that local spindle-burst oscillations, driven by glutamatergic synapses and spatially confined by GABAergic synapses, contribute to the development of barrel cortex during the critical period of developmental plasticity...
  23. pmc A selective interplay between aberrant EPSPKA and INaP reduces spike timing precision in dentate granule cells of epileptic rats
    Jérôme Epsztein
    INMED, INSERM U901, Universite de la Mediterranee, Parc Scientifique de Luminy, BP 13, 13273, Marseille Cedex 09, France
    Cereb Cortex 20:898-911. 2010
    ..We conclude that a selective interplay between aberrant EPSP(KA) and I(NaP) severely alters the temporal precision of EPSP-spike coupling in DGCs of chronic epileptic rats...
  24. doi Layer-specific generation and propagation of seizures in slices of developing neocortex: role of excitatory GABAergic synapses
    Sylvain Rheims
    Institut de Neurobiologie de la Mediterranee, Institut National de la Sante et de la Recherche Medicale U901, Universite de la Mediterranee, Marseille, France
    J Neurophysiol 100:620-8. 2008
    ..In superficial layers, a persistent increase in excitability of pyramidal neurons caused by Em depolarization is associated with a transition from largely confined GABAergic IIS to ictal events that entrain the entire neocortex...
  25. ncbi Ongoing epileptiform activity in the post-ischemic hippocampus is associated with a permanent shift of the excitatory-inhibitory synaptic balance in CA3 pyramidal neurons
    Jérôme Epsztein
    Institut de Neurobiologie de la Mediterranee, and Université de la Méditerranée, Parc Scientifique de Luminy, 13273 Marseille Cedex 09, France
    J Neurosci 26:7082-92. 2006
    ....
  26. ncbi Synaptic kainate receptors tune oriens-lacunosum moleculare interneurons to operate at theta frequency
    Miri Goldin
    Institut de Neurobiologie de la Méditeranée, INSERM, Unite 29, Universite de la Mediterranee, Parc Scientifique de Luminy, 13273 Marseille Cedex 9, France
    J Neurosci 27:9560-72. 2007
    ..Such preferential processing of excitatory inputs via KA-Rs by distally projecting GABAergic microcircuits could provide a key role in theta band frequency oscillations...
  27. ncbi Early sequential formation of functional GABA(A) and glutamatergic synapses on CA1 interneurons of the rat foetal hippocampus
    Sonia Hennou
    INMED INSERM Unite 29, Universite de la Mediterranee, 163, route de Luminy, BP 13, 13273 Marseille Cedex 9, France
    Eur J Neurosci 16:197-208. 2002
    ..Interneurons are the source and the target of the first synapses formed in the hippocampus and are thus in a position to modulate the development of the hippocampus in the foetal stage...
  28. doi Inhibitory actions of the gamma-aminobutyric acid in pediatric Sturge-Weber syndrome
    Roman Tyzio
    INMED INSERM U901, Marseille, Paris, France
    Ann Neurol 66:209-18. 2009
    ..We explored the properties of neurons from human pediatric SWS cortex in vitro and tested in particular whether gamma-aminobutyric acid (GABA) excites neurons in SWS cortex, as has been suggested for various types of epilepsies...
  29. ncbi Paracrine intercellular communication by a Ca2+- and SNARE-independent release of GABA and glutamate prior to synapse formation
    Michael Demarque
    Institut de Neurobiologie de la Mediterranee, INMED, Institut de la Sante et de la Recherche Medicale, INSERM U29, Parc Scientifique de Luminy, BP13, 13273 09, Marseille Cedex, France
    Neuron 36:1051-61. 2002
    ..Thus, a Ca(2+)- and SNARE-independent release of transmitters underlies a paracrine mode of communication before synapse formation...
  30. ncbi Stiripentol, a putative antiepileptic drug, enhances the duration of opening of GABA-A receptor channels
    Pascale P Quilichini
    INSERM U29 INMED, Marseille, France
    Epilepsia 47:704-16. 2006
    ..In addition, STP directly reduces seizures in several animal models of epilepsy, suggesting that it might also have anticonvulsive effects of its own. However, its underlying mechanisms of action are unknown...
  31. doi Sequential generation of two distinct synapse-driven network patterns in developing neocortex
    Camille Allene
    Institut de Neurobiologie de la Mediterranee, INSERM U901, Universite de la Mediterranee, 13273 Marseille Cedex 9, France
    J Neurosci 28:12851-63. 2008
    ..Therefore, cENOs and cGDPs are two separate aspects of neocortical network maturation that may be differentially engaged in physiological and pathological processes...
  32. ncbi Recurrent mossy fibers establish aberrant kainate receptor-operated synapses on granule cells from epileptic rats
    Jérôme Epsztein
    Institut de Neurobiologie de la Mediterranee, Institut National de la Sante et de la Recherche Medicale, Unite 29, Universite de la Mediterranee, Parc Scientifique de Luminy, 13273 Marseille Cedex 09, France
    J Neurosci 25:8229-39. 2005
    ..Therefore, in addition to axonal rewiring, sprouting of mossy fibers induces a shift in the nature of glutamatergic transmission in granule cells that may contribute to the physiopathology of the dentate gyrus in epileptic animals...
  33. ncbi Glutamate acting on AMPA but not NMDA receptors modulates the migration of hippocampal interneurons
    Jean Bernard Manent
    Institut de Neurobiologie de la Mediterranee, Institut National de la Sante et de la Recherche Medicale, Unite 29, 13273 Marseille, France
    J Neurosci 26:5901-9. 2006
    ..It might constitute a primitive homeostatic mechanism in the developing brain that acts to balance GABA-glutamate contributions to network construction and activity...
  34. ncbi Generation of slow network oscillations in the developing rat hippocampus after blockade of glutamate uptake
    Adriano Augusto Cattani
    Institut de Neurobiologie de la Méditerranée INMED, Institut National de la Santé et de la Recherche Médicale U29 INSERMU29, Universite de la Mediterranee, Marseille, France
    J Neurophysiol 98:2324-36. 2007
    ..This periodic neuronal coactivation may contribute to the generation of seizures when glutamate transport dysfunction is present...
  35. ncbi A parturition-associated nonsynaptic coherent activity pattern in the developing hippocampus
    Valerie Crepel
    INMED, INSERM, U29, Universite de la Mediterranee, Parc Scientifique de Luminy, BP 13, 13273 Marseille Cedex 09, France
    Neuron 54:105-20. 2007
    ..Therefore, in the developing hippocampus, delivery is an important signal that triggers the first coherent activity pattern, which is silenced by the emergence of synaptic transmission...
  36. ncbi Quantal release of glutamate generates pure kainate and mixed AMPA/kainate EPSCs in hippocampal neurons
    Rosa Cossart
    INMED INSERM U 29 and Université de La Méditerranée, Parc Scientifique de Luminy, BP 13, 13273 Marseille Cedex 9, France
    Neuron 35:147-59. 2002
    ..Kainate receptors are, therefore, key players of the ongoing glutamatergic transmission in the hippocampus...
  37. doi Depolarizing actions of GABA in immature neurons depend neither on ketone bodies nor on pyruvate
    Roman Tyzio
    INSERM, Unité 901 Institut de Neurobiologie de Méditerranée, 13273 Marseille, France
    J Neurosci 31:34-45. 2011
    ..There is no need to alter conventional glucose enriched artificial CSF to investigate GABA signals in the developing brain...
  38. ncbi Inhibition of glutamate transporters results in a "suppression-burst" pattern and partial seizures in the newborn rat
    Mathieu Milh
    INMED INSERM U29, Universite de la Mediterranee, Marseille, France
    Epilepsia 48:169-74. 2007
    ..To determine the electrophysiological pattern and propose a clinical relevance of a deficient glutamate transport in the developing brain...
  39. pmc A conserved switch in sensory processing prepares developing neocortex for vision
    Matthew T Colonnese
    INSERM, U901, INMED, Aix Marseille Universite, Faculte des Sciences, 13273 Marseille, France
    Neuron 67:480-98. 2010
    ..Thus, the early development of visual processing is governed by a conserved, intrinsic program that switches thalamocortical response properties in anticipation of patterned vision...
  40. ncbi Glutamate transporters prevent the generation of seizures in the developing rat neocortex
    Michael Demarque
    Institut de Neurobiologie de la Méditerranée Institut National de la Santé et de la Recherche Médicale U29, Parc Scientifique de Luminy, 13009 Marseille, France
    J Neurosci 24:3289-94. 2004
    ..A dysfunction of glutamate transporters may be a central event in early infancy epilepsy syndromes...
  41. doi Bumetanide, an NKCC1 antagonist, does not prevent formation of epileptogenic focus but blocks epileptic focus seizures in immature rat hippocampus
    Romain Nardou
    Institut de Neurobiologie de la Mediterranee, Institut National de la Santé et de la Recherche Médicale Unité 901, 13273 Marseille Cedex 09, France
    J Neurophysiol 101:2878-88. 2009
    ..We suggest that an additional mechanism other than NKCC1-mediated contributes to the persistent increase of DF(GABA) in epileptic neurons...
  42. pmc Early expression of KCC2 in rat hippocampal cultures augments expression of functional GABA synapses
    Ilona Chudotvorova
    INMED INSERM Unite 29, 163 Route de Luminy, 13009 Marseille, France
    J Physiol 566:671-9. 2005
    ..We conclude that the expression of KCC2 and the reduction of [Cl-]i play a critical role in the construction of GABAergic networks that extends beyond the excitatory to inhibitory shift of the actions of GABA...
  43. ncbi Epileptogenic actions of GABA and fast oscillations in the developing hippocampus
    Ilgam Khalilov
    INMED INSERM, U 29 Marseille, 163, route de Luminy, 13273 Marseille Cedex 09, France
    Neuron 48:787-96. 2005
    ..We suggest that the synergistic actions of GABA and NMDA receptors trigger the cascades involved in epileptogenesis in the developing hippocampus...
  44. doi Oxytocin-mediated GABA inhibition during delivery attenuates autism pathogenesis in rodent offspring
    Roman Tyzio
    Mediterranean Institute of Neurobiology INMED, U901, INSERM, Marseille, France
    Science 343:675-9. 2014
    ..Our data validate the amelioration observed with bumetanide and oxytocin and point to common pathways in a drug-induced and a genetic rodent model of autism. ..
  45. ncbi Fetal exposure to GABA-acting antiepileptic drugs generates hippocampal and cortical dysplasias
    Jean Bernard Manent
    INMED, INSERM U29, Universite de la Mediterranee, Campus de Luminy, Marseille, France
    Epilepsia 48:684-93. 2007
    ..The purpose of this study was to investigate the consequences of prenatal exposure to (a) different AEDs and (b) maternal seizures on brain maturational processes in rats...
  46. doi Dopamine-deprived striatal GABAergic interneurons burst and generate repetitive gigantic IPSCs in medium spiny neurons
    Nathalie Dehorter
    Institut de Neurobiologie de Méditerranée Unité Mixte de Recherche 901, Inserm and Aix Marseille II University, 13009 Marseille, France
    J Neurosci 29:7776-87. 2009
    ..We suggest that this may in turn alter integration of cortical signals by MSNs...
  47. doi (R)-roscovitine, a cyclin-dependent kinase inhibitor, enhances tonic GABA inhibition in rat hippocampus
    A Ivanov
    INSERM U29 INMED, 163 Route de Luminy, 13273, Marseille, France
    Neuroscience 156:277-88. 2008
    ..Therefore, (R)-roscovitine is a potent modulator of neuronal activity in rat hippocampus and may provide a tool for preventing paroxysmal activity...
  48. ncbi Paradoxical anti-epileptic effects of a GluR5 agonist of kainate receptors
    Ilgam Khalilov
    Institut de Neurobiologie de la Mediterranee, Institut National de la Sante et de la Recherche Medicale, U29, Marseille, France
    J Neurophysiol 88:523-7. 2002
    ..We conclude that the selective excitation of interneurons by GluR5-containing kainate receptor agonists opens a new therapeutic approach for the epilepsies...
  49. doi Neuronal chloride accumulation and excitatory GABA underlie aggravation of neonatal epileptiform activities by phenobarbital
    Romain Nardou
    INSERM U 901, Marseille, 13009, France
    Brain 134:987-1002. 2011
    ....
  50. pmc Spontaneous synaptic activity is required for the formation of functional GABAergic synapses in the developing rat hippocampus
    Isabelle Colin-Le Brun
    Institut de Neurobiologie de la Méditerranée INMED, Institut National de la Sante et de la Recherche Medicale INSERM, Unite 29, BP 13, 13273 Marseille Cedex 09, France
    J Physiol 559:129-39. 2004
    ....
  51. ncbi Early motor activity drives spindle bursts in the developing somatosensory cortex
    Rustem Khazipov
    INMED, INSERM U29, Avenue de Luminy, B P 13, 13273 Marseille, France
    Nature 432:758-61. 2004
    ..We suggest that the interaction between movement-triggered sensory feedback signals and self-organized spindle oscillations shapes the formation of cortical connections required for sensorimotor coordination...
  52. doi Effects of oxytocin on GABA signalling in the foetal brain during delivery
    Rustem Khazipov
    INMED INSERM U29, Universite de la Mediterranee, Marseille, France
    Prog Brain Res 170:243-57. 2008
    ..Neuronal death caused by anoxic-aglycaemic episodes was substantially delayed in the foetal hippocampus by endogenous OXT. These findings suggest that OXT plays important role in the preparation of the foetal brain to delivery...
  53. doi Antiepileptic drugs and brain maturation: fetal exposure to lamotrigine generates cortical malformations in rats
    Jean Bernard Manent
    INSERM U29, INMED, Marseille F 13009, France
    Epilepsy Res 78:131-9. 2008
    ..These observations raise concerns about potential clinical correlates and call for detailed comparative investigations on the consequences of AED use during pregnancy...
  54. ncbi Correlated bursts of activity in the neonatal hippocampus in vivo
    Xavier Leinekugel
    INMED, Institut National de la Santé et de la Recherche Médicale INSERM U29, Avenue de Luminy, Boite Postale 13, 13273 Marseille Cedex 09, France
    Science 296:2049-52. 2002
    ..This earliest pattern, which diversifies during the second postnatal week, could provide correlated activity for immature neurons and may underlie activity-dependent maturation of the hippocampal network...
  55. ncbi Correlative fluorescence and electron microscopy of biocytin-filled neurons with a preservation of the postsynaptic ultrastructure
    Youri Morozov
    INMED INSERM U29, 163 Route de Luminy, BP 13, 13009 Marseille, France
    J Neurosci Methods 117:81-5. 2002
    ....
  56. ncbi Long-term plasticity at GABAergic and glycinergic synapses: mechanisms and functional significance
    Jean Luc Gaiarsa
    INMED INSERM U29, Avenue de Luminy, B P 13, 13273 Marseille Cedex 09, France
    Trends Neurosci 25:564-70. 2002
    ..Here we review these different forms of plasticity and focus on their possible roles in developing and adult neuronal networks...
  57. ncbi Effects of antiepileptic drugs on refractory seizures in the intact immature corticohippocampal formation in vitro
    Pascale Paule Quilichini
    INMED INSERM U29, Marseille, France
    Epilepsia 44:1365-74. 2003
    ..The better to characterize this model, we examined the effects of 14 antiepileptic drugs (AEDs) currently used in clinical practice...
  58. ncbi Rapid cortical oscillations and early motor activity in premature human neonate
    Mathieu Milh
    INMED INSERM U29, Universite de la Mediterranee, Marseille, France
    Cereb Cortex 17:1582-94. 2007
    ....
  59. ncbi Multiple facets of GABAergic neurons and synapses: multiple fates of GABA signalling in epilepsies
    Rosa Cossart
    INMED INSERM, 163 Route de Luminy, 13273 Marseille Cedex 09, Marseille, France
    Trends Neurosci 28:108-15. 2005
    ..This review is part of the TINS Interneuron Diversity series...
  60. ncbi Trophic actions of GABA on neuronal development
    Alfonso Represa
    INMED INSERM U29, Parc Scientifique et Technologique de Luminy, Marseille, France
    Trends Neurosci 28:278-83. 2005
    ..This sequence also implies that by altering these effects, drugs acting on the GABA system could be pathogenic during pregnancy...
  61. ncbi Cholinergic modulation of spindle bursts in the neonatal rat visual cortex in vivo
    Ileana L Hanganu
    Institut de Neurobiologie de la Mediterranee, Institut National de la Santé et de la Recherche Médicale U29, 13273 Marseille, France
    J Neurosci 27:5694-705. 2007
    ..Thus, the cholinergic input facilitates the neonatal V1 spindle bursts and may prime the developing cortex to operate specifically on relevant early (retinal waves) and later (visual input) stimuli...
  62. pmc Opposing role of synaptic and extrasynaptic NMDA receptors in regulation of the extracellular signal-regulated kinases (ERK) activity in cultured rat hippocampal neurons
    Anton Ivanov
    INMED INSERM Unite 29, 163 Route de Luminy, 13009 Marseille, France
    J Physiol 572:789-98. 2006
    ..The negative regulation of the ERK activity might be one of the first signalling events determining brain injury and constitutes a putative target of new pharmacological applications...
  63. ncbi Retinal waves trigger spindle bursts in the neonatal rat visual cortex
    Ileana L Hanganu
    Institut de Neurobiologie de la Méditeranée, Université de la Méditeranée, Institut National de la Santé et de la Recherche Médicale U29, 13273 Marseille, France
    J Neurosci 26:6728-36. 2006
    ..We propose that the interaction between retinal waves and spindle bursts contributes to the development of visual pathways to the cortex...
  64. ncbi Increased levels of acidic calponin during dendritic spine plasticity after pilocarpine-induced seizures
    Lotfi Ferhat
    INMED INSERM U29, Marseille, France
    Hippocampus 13:845-58. 2003
    ..Altogether, these results are consistent with an involvement of acidic calponin in dendritic spine plasticity...
  65. ncbi Neurotransmitters and brain maturation: early paracrine actions of GABA and glutamate modulate neuronal migration
    Jean Bernard Manent
    Institut de Neurobiologie de la Méditerranée INMED Institut National de la Santé et de la Recherche Médicale INSERM, Marseille, France
    Neuroscientist 13:268-79. 2007
    ..A hypothesis is proposed that these differential actions in different cell types arise from a "homeostatic-like" regulation that controls final position, timing, and number of cells at destination...
  66. ncbi In vivo blockade of neural activity alters dendritic development of neonatal CA1 pyramidal cells
    Laurent Groc
    Institute of Physiology and Pharmacology, Department of Physiology, Goteborg University, Goteborg, Sweden
    Eur J Neurosci 16:1931-8. 2002
    ..The apical dendrite, the axons, or the soma grew normally during activity deprivation. Thus, the in vivo neural activity in the neonate hippocampus seems to promote neuronal growth by initiating novel branches...
  67. ncbi Late-onset epileptogenesis and seizure genesis: lessons from models of cerebral ischemia
    Jérôme Epsztein
    Institut de Neurobiologie de la Mediterranee, Institut National de la Santé et de la Recherche Médicale Unité 29, and Université de la Méditerranée, Marseille Cedex, France
    Neuroscientist 14:78-90. 2008
    ..In particular, this review emphasizes the change in GABAergic and glutamatergic signaling leading to hyperexcitability and seizure genesis...
  68. ncbi Interneurons are the source and the targets of the first synapses formed in the rat developing hippocampal circuit
    Henri Gozlan
    INMED INSERM U29, 163 Route de Luminy, BP 13, 13273 Marseille Cedex 9, France
    Cereb Cortex 13:684-92. 2003
    ..They could therefore play a central role in the formation of the cortical circuit at early developmental stages...
  69. ncbi Endogenous neurotrophins are required for the induction of GABAergic long-term potentiation in the neonatal rat hippocampus
    Paolo Gubellini
    Laboratoire Interactions Cellulaires, Neurodégénérescence et Neuroplasticité, Centre National de la Recherche Scientifique Unité Mixte de Recherche 6186, 13402 Marseille Cedex 20, France
    J Neurosci 25:5796-802. 2005
    ..Altogether, these data indicate that endogenous TrkB ligands and associated PTK activity are necessary for the induction of GABAergic LTP in the developing rat hippocampus...
  70. ncbi In vitro formation of a secondary epileptogenic mirror focus by interhippocampal propagation of seizures
    Ilgam Khalilov
    Institut de Neurobiologie de la Mediterranee INMED INSERM U29, 163 Route de Luminy, Marseilles 13273, France
    Nat Neurosci 6:1079-85. 2003
    ..These data indicate that the excitatory actions of GABA may be a fundamental property of epileptogenic structures...
  71. ncbi The dark side of high-frequency oscillations in the developing brain
    Michel Le Van Quyen
    LENA CNRS UPR640, Universite Pierre et Marie Curie, Hopital de la Salpetriere, 47 Boulevard de l Hopital, 75651 Paris Cedex 13, France
    Trends Neurosci 29:419-27. 2006
    ..This review is part of the INMED/TINS special issue "Nature and nurture in brain development and neurological disorders", based on presentations at the annual INMED/TINS symposium (http://inmednet.com/)...
  72. ncbi The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1
    Grigory Krapivinsky
    Howard Hughes Medical Institute, Children s Hospital, 1309 Enders Building, 320 Longwood Avenue, Boston, MA 02115, USA
    Neuron 40:775-84. 2003
    ..The specific association of RasGRF1 with the NR2B subunit and study of ERK activation in neurons with varied content of NR2B suggests that NR2B-containing channels are the dominant activators of the NMDA-dependent ERK pathway...
  73. ncbi A single episode of neonatal seizures permanently alters glutamatergic synapses
    Gregory L Holmes
    Ann Neurol 61:379-81. 2007
  74. ncbi Compensatory dendritic growth of CA1 pyramidal cells following growth impairment in the neonatal period
    Laurent Groc
    Institute of Physiology and Pharmacology, Department of Physiology, Goteborg University, Goteborg, Sweden
    Eur J Neurosci 18:1332-6. 2003
    ..These results suggest that the early hippocampal activity controls the growth rate but is not necessary for the generation of an adult normal basal dendritic tree...