C Belzung

Summary

Country: France

Publications

  1. doi request reprint Mouse strain differences in the unpredictable chronic mild stress: a four-antidepressant survey
    Ipek Yalcin
    Universite Francois Rabelais de Tours, France
    Behav Brain Res 193:140-3. 2008
  2. pmc Criteria of validity for animal models of psychiatric disorders: focus on anxiety disorders and depression
    Catherine Belzung
    U930, UFR Sciences et Techniques, Parc Grandmont, Rue Monge, Tours, 37200, France
    Biol Mood Anxiety Disord 1:9. 2011
  3. ncbi request reprint Neuropeptides in psychiatric diseases: an overview with a particular focus on depression and anxiety disorders
    C Belzung
    EA3248, Psychobiologie des Emotions, UFR Sciences et Techniques, Parc Grandmont, 37200 Tours, France
    CNS Neurol Disord Drug Targets 5:135-45. 2006
  4. pmc Anxiety from a phylogenetic perspective: is there a qualitative difference between human and animal anxiety?
    Catherine Belzung
    EA3248 Psychobiologie des Emotions, UFR Sciences et Techniques, Universite Francois Rabelais, Tours 37200, France
    Neural Plast 2007:59676. 2007
  5. ncbi request reprint Behavioral and neurochemical changes following predatory stress in mice
    C Belzung
    EA 3248 Psychobiologie des Emotions, Faculte des Sciences et Techniques, Universite Francois Rabelais, Parc de Grandmont, 37200 Tours, France
    Neuropharmacology 41:400-8. 2001
  6. ncbi request reprint Flumazenil induces benzodiazepine partial agonist-like effects in BALB/c but not C57BL/6 mice
    C Belzung
    Laboratoire d Ethologie et de Pharmacologie du Comportement, Faculte des Sciences, Parc Grandmont, 37200 Tours, France
    Psychopharmacology (Berl) 148:24-32. 2000
  7. ncbi request reprint Naloxone potentiates the effects of subeffective doses of anxiolytic agents in mice
    C Belzung
    Laboratoire d Ethologie et de Pharmacologie du Comportement, Faculte des Sciences, Tours, France
    Eur J Pharmacol 323:133-6. 1997
  8. ncbi request reprint Correlations between behaviours in the elevated plus-maze and sensitivity to unpredictable subchronic mild stress: evidence from inbred strains of mice
    C Ducottet
    EA3248 Psychobiologie des Emotions, UFR des Sciences et Techniques, Parc de Grandmont, 37200 Tours, France
    Behav Brain Res 156:153-62. 2005
  9. ncbi request reprint Naloxone potentiates anxiolytic-like actions of diazepam, pentobarbital and meprobamate but not those of Ro19-8022 in the rat
    C Belzung
    Laboratoire d Ethologie et de Pharmacologie du Comportement, Faculte des Sciences, Universite de Tours, Tours, France
    Eur J Pharmacol 394:289-94. 2000
  10. ncbi request reprint Naloxone blocks anxiolytic-like effects of benzodiazepines in Swiss but not in Balb/c mice
    C Belzung
    Laboratoire d Ethologie et de Pharmacologie du Comportement, Faculté Sciences et Techniques, Tours, France
    Psychopharmacology (Berl) 132:195-201. 1997

Detail Information

Publications47

  1. doi request reprint Mouse strain differences in the unpredictable chronic mild stress: a four-antidepressant survey
    Ipek Yalcin
    Universite Francois Rabelais de Tours, France
    Behav Brain Res 193:140-3. 2008
    ..In conclusion, these results emphasize that BALB/c mice are more sensitive than Swiss mice for studying the effects of the UCMS model as well as for testing antidepressant-like properties...
  2. pmc Criteria of validity for animal models of psychiatric disorders: focus on anxiety disorders and depression
    Catherine Belzung
    U930, UFR Sciences et Techniques, Parc Grandmont, Rue Monge, Tours, 37200, France
    Biol Mood Anxiety Disord 1:9. 2011
    ..The relevance of this framework is then discussed regarding various animal models of depression...
  3. ncbi request reprint Neuropeptides in psychiatric diseases: an overview with a particular focus on depression and anxiety disorders
    C Belzung
    EA3248, Psychobiologie des Emotions, UFR Sciences et Techniques, Parc Grandmont, 37200 Tours, France
    CNS Neurol Disord Drug Targets 5:135-45. 2006
    ..At the systemic level, a neuropeptide can play a direct role in the expression of a symptom of the disease. This is illustrated by different examples...
  4. pmc Anxiety from a phylogenetic perspective: is there a qualitative difference between human and animal anxiety?
    Catherine Belzung
    EA3248 Psychobiologie des Emotions, UFR Sciences et Techniques, Universite Francois Rabelais, Tours 37200, France
    Neural Plast 2007:59676. 2007
    ..g., the vegetative and central nervous systems). The ability to assess one's coping potential, the diversification of the anxiety responses, and autonoetic consciousness seem relevant markers in a phylogenetic perspective...
  5. ncbi request reprint Behavioral and neurochemical changes following predatory stress in mice
    C Belzung
    EA 3248 Psychobiologie des Emotions, Faculte des Sciences et Techniques, Universite Francois Rabelais, Parc de Grandmont, 37200 Tours, France
    Neuropharmacology 41:400-8. 2001
    ..Taken together, these findings indicate that the exposure of mice to unavoidable predatory stimuli is associated with behavioral and neurochemical changes consistent with increased anxiety...
  6. ncbi request reprint Flumazenil induces benzodiazepine partial agonist-like effects in BALB/c but not C57BL/6 mice
    C Belzung
    Laboratoire d Ethologie et de Pharmacologie du Comportement, Faculte des Sciences, Parc Grandmont, 37200 Tours, France
    Psychopharmacology (Berl) 148:24-32. 2000
    ..Some anxiety disorders may be treated in a different way than normal anxiety...
  7. ncbi request reprint Naloxone potentiates the effects of subeffective doses of anxiolytic agents in mice
    C Belzung
    Laboratoire d Ethologie et de Pharmacologie du Comportement, Faculte des Sciences, Tours, France
    Eur J Pharmacol 323:133-6. 1997
    ..5 mg/kg, chlordiazepoxide 5 mg/kg and buspirone 4 mg/kg). Naloxone alone (10 mg/kg) had no intrinsic effect. These data suggest that naloxone is able to potentiate the effects of anti-anxiety agents...
  8. ncbi request reprint Correlations between behaviours in the elevated plus-maze and sensitivity to unpredictable subchronic mild stress: evidence from inbred strains of mice
    C Ducottet
    EA3248 Psychobiologie des Emotions, UFR des Sciences et Techniques, Parc de Grandmont, 37200 Tours, France
    Behav Brain Res 156:153-62. 2005
    ..These results suggest that anxiety may be a factor contributing, among others, to the susceptibility to depressive-like behaviours...
  9. ncbi request reprint Naloxone potentiates anxiolytic-like actions of diazepam, pentobarbital and meprobamate but not those of Ro19-8022 in the rat
    C Belzung
    Laboratoire d Ethologie et de Pharmacologie du Comportement, Faculte des Sciences, Universite de Tours, Tours, France
    Eur J Pharmacol 394:289-94. 2000
    ..Another possibility is that naloxone blocks opioid effects on adenosinergic systems...
  10. ncbi request reprint Naloxone blocks anxiolytic-like effects of benzodiazepines in Swiss but not in Balb/c mice
    C Belzung
    Laboratoire d Ethologie et de Pharmacologie du Comportement, Faculté Sciences et Techniques, Tours, France
    Psychopharmacology (Berl) 132:195-201. 1997
    ..Therefore, the ability of naloxone to reverse anxiolytic effects does not hold for all strains of mice...
  11. ncbi request reprint Anxiolytic-like effects of meprobamate. Interactions with an opiate antagonist in Swiss and BALB/c mice
    C Belzung
    Laboratoire d Ethologie et Pharmacologie du Comportement, Faculte des Sciences, Universite de Tours, Tours, France
    Pharmacol Biochem Behav 65:465-74. 2000
    ..This suggests that the mechanisms behind naloxone's blockade of anxiolytic-like effects are independent from those behind its potentiation of such effects...
  12. ncbi request reprint Measuring normal and pathological anxiety-like behaviour in mice: a review
    C Belzung
    EA 3248 Psychobiologie des Emotions, UFR Sciences et Techniques, Parc Grandmont, Avenue Monge, F 37200 Tours, France
    Behav Brain Res 125:141-9. 2001
    ..Inbred strains of mice, such as the BALB/c line, which exhibits spontaneously elevated anxiety appear to be a more suitable model of pathological anxiety...
  13. ncbi request reprint An investigation of the mechanisms responsible for acute fluoxetine-induced anxiogenic-like effects in mice
    C Belzung
    EA 3248 Psychobiologie des Emotions, UFR Sciences et Techniques, Tours, France
    Behav Pharmacol 12:151-62. 2001
    ....
  14. ncbi request reprint Naloxone potentiates the anxiolytic but not the amnestic action of chlordiazepoxide in C57BL/6 mice
    C Belzung
    Laboratoire d Ethologie et de Pharmacologie du Comportement, Faculte des Sciences, Tours, France
    Behav Pharmacol 9:691-8. 1998
    ..Naloxone elicited no intrinsic action in any of these behavioural models. It can be concluded that naloxone potentiates the anxiolytic but not the amnestic action of chlordiazepoxide...
  15. ncbi request reprint The genetic basis of the pharmacological effects of anxiolytics: a review based on rodent models
    C Belzung
    EA 3248 Psychobiologie des Emotions, UFR Sciences et Techniques, Parc Grandmont, F 37200 Tours, France
    Behav Pharmacol 12:451-60. 2001
    ..It is suggested that the strain differences in anxiety-like behaviour may be used as a tool in assaying anxiolytic activity of new drugs...
  16. ncbi request reprint Emotional reactivity in mice, a case of nongenetic heredity?
    F Calatayud
    EA 3248 Psychobiologie des Emotions, Faculte de Sciences et Techniques, Parc de Grandmont, Tours 37200, France
    Physiol Behav 74:355-62. 2001
    ..In the light/dark box, no difference has been found between the two hybrids. Moreover, the mother's influence is greater in males than in females...
  17. pmc Antidepressants recruit new neurons to improve stress response regulation
    A Surget
    U930 Imaging and Brain, INSERM, Tours, France
    Mol Psychiatry 16:1177-88. 2011
    ....
  18. ncbi request reprint Beta-CCT, a selective BZ-omega1 receptor antagonist, blocks the anti-anxiety but not the amnesic action of chlordiazepoxide in mice
    C Belzung
    Laboratoire d Ethologie et de Pharmacologie du Comportement, UFR Sciences et Techniques, Tours, France
    Behav Pharmacol 11:125-31. 2000
    ..These results are in agreement with previous studies using selective BZ-omega1 agonists, and thus provide further evidence that BZ-omega1 receptors may be involved in the anxiolytic but not in the amnesic effects of BZ agonists...
  19. ncbi request reprint Further pharmacological validation of the BALB/c neophobia in the free exploratory paradigm as an animal model of trait anxiety
    C Belzung
    Laboratoire d Ethologie et de Pharmacologie du Comportement, UFR Sciences et Techniques, Tours, France
    Behav Pharmacol 8:541-8. 1997
    ..Because of its chronicity, this paradigm may model generalized anxiety, a pathology that has been suggested to overlap trait anxiety...
  20. ncbi request reprint Absence of cocaine-induced place conditioning in serotonin 1B receptor knock-out mice
    C Belzung
    LEPCO, UFR Sciences et Techniques, Parc Grandmont, F 37200 Tours, France
    Pharmacol Biochem Behav 66:221-5. 2000
    ..As other studies showed that 5-HT1B knock-out mice self-administer cocaine, these results suggest a dissociation between the psychologic state linked to self-administration and the one measured in conditioned place preference...
  21. ncbi request reprint Rodent models of anxiety-like behaviors: are they predictive for compounds acting via non-benzodiazepine mechanisms?
    C Belzung
    EA 3248 Psychobiologie des Emotions, Faculte des Sciences et Techniques, Universite de Tours, France
    Curr Opin Investig Drugs 2:1108-11. 2001
    ....
  22. ncbi request reprint Long-term impaired memory following predatory stress in mice
    Wissam El Hage
    EA3248 and IFR135, Universite Francois Rabelais, Faculté Sciences et Techniques, Parc Grandmont, 37200 Tours, France
    Physiol Behav 87:45-50. 2006
    ..This animal model of unique exposure of mice to unavoidable predatory stimuli has proven to be a useful model for the study of reactions to traumatic stress...
  23. doi request reprint Effects of 5,7-dihydroxytryptamine lesion of the dorsal raphe nucleus on the antidepressant-like action of tramadol in the unpredictable chronic mild stress in mice
    Ipek Yalcin
    INSERM U 930 FRE CNRS 2448, Faculte des Sciences et Techniques, Universite Francois Rabelais, Parc Grandmont, 37200 Tours, France
    Psychopharmacology (Berl) 200:497-507. 2008
    ....
  24. doi request reprint Peripheral and cerebral metabolic abnormalities of the tryptophan-kynurenine pathway in a murine model of major depression
    Anthony Laugeray
    UMRS Inserm U930, CNRS ERL 3106, Universite Francois Rabelais, Tours, France
    Behav Brain Res 210:84-91. 2010
    ..Considering the role of these metabolites on the glutamatergic neurotransmission, we propose that such KP alterations could participate to the cortical/subcortical glutamatergic alterations reported in depressed patients...
  25. ncbi request reprint Trauma-related deficits in working memory
    Wissam El-Hage
    Faculté Sciences et Techniques and Clinique Psychiatrique Universitaire, Tours, France
    Cogn Neuropsychiatry 11:33-46. 2006
    ..The aim of the study was to evaluate trauma-related impairments of working memory in psychiatric outpatients, and the mediating role of processing speed, anxiety and depression in the cognitive decrements...
  26. doi request reprint Olfactory anhedonia and negative olfactory alliesthesia in depressed patients
    Boriana Atanasova
    UMR INSERM U930 CNRS ERL 3106, Universite Francois Rabelais de Tours, Tours, France
    Psychiatry Res 176:190-6. 2010
    ..Further studies are needed to replicate these findings and to confirm that such olfactory anhedonia or/and olfactory negative alliesthesia could be a state or a trait of depression...
  27. ncbi request reprint Susceptibility to subchronic unpredictable stress is related to individual reactivity to threat stimuli in mice
    C Ducottet
    EA3248 Psychobiologie des Emotions, UFR des Sciences et Techniques, Parc de Grandmont, 37 200 Tours, France
    Behav Brain Res 155:291-9. 2004
    ..These results are discussed regarding their relevance for the understanding of aetiologies of depressive illnesses...
  28. ncbi request reprint Effects of the selective nonpeptide corticotropin-releasing factor receptor 1 antagonist antalarmin in the chronic mild stress model of depression in mice
    Cecile Ducottet
    EA 3248 Psychobiologie des Emotions, IFR120 Imagerie et exploration fonctionnelles, Faculte des Sciences and Techniques, UFR Sciences et Techniques, Universite Francois Rabelais, Parc de Grandmont Avenue Monge, F 37200, Tours, France
    Prog Neuropsychopharmacol Biol Psychiatry 27:625-31. 2003
    ..Chronic treatment with antalarmin (10 mg/kg ip) and fluoxetine (10 mg/kg ip) led to an improvement of CMS-induced modifications. These results suggest that CRF(1) receptor antagonists may represent potential antidepressants...
  29. pmc Open questions in current models of antidepressant action
    A Tanti
    INSERM U 930, Université François Rabelais Tours, UFR Sciences et Techniques, Parc Grandmont, Tours, France
    Br J Pharmacol 159:1187-200. 2010
    ....
  30. ncbi request reprint Prenatal 3,4-methylenedioxymethamphetamine (ecstasy) exposure induces long-term alterations in the dopaminergic and serotonergic functions in the rat
    Laurent Galineau
    INSERM U619, IFR135, Laboratoire de Biophysique Médicale and Pharmaceutique, Université François Rabelais des Sciences Pharmaceutiques, 31 Avenue Monge, 37200 Tours, France
    Brain Res Dev Brain Res 154:165-76. 2005
    ..This study suggests that a prenatal exposure to MDMA induces transient and long-term neurochemical and behavioural modifications in dopaminergic and serotonergic functions...
  31. doi request reprint Effects of neuronal and inducible NOS inhibitor 1-[2-(trifluoromethyl) phenyl] imidazole (TRIM) in unpredictable chronic mild stress procedure in mice
    Oguz Mutlu
    Universite Francois Rabelais, Parc Grandmont, F 37200 Tours, France
    Pharmacol Biochem Behav 92:82-7. 2009
    ..These results support the assumption that NOS inhibitors can be a new class of antidepressant drugs possibly acting on neuronal NOS...
  32. ncbi request reprint Impaired memory following predatory stress in mice is improved by fluoxetine
    Wissam El Hage
    EA3248 Psychobiologie des Emotions and IFR120, Faculté Sciences et Techniques, Parc Grandmont, 37200 Tours, France
    Prog Neuropsychopharmacol Biol Psychiatry 28:123-8. 2004
    ..Taken together, these findings indicate that this animal model of exposure of mice to unavoidable predatory stimuli produces early cognitive changes analogous to those seen in patients with acute stress disorder (ASD)...
  33. ncbi request reprint Antidepressant-like effect of tramadol in the unpredictable chronic mild stress procedure: possible involvement of the noradrenergic system
    Ipek Yalcin
    EA 3248 Psychobiology of Emotions, Faculty of Science and Technics, Parc Grandmont, University François Rabelais Tours, France
    Behav Pharmacol 18:623-31. 2007
    ..These data support the view that the noradrenergic system plays an important role in the antidepressant-like action of tramadol...
  34. ncbi request reprint Effects of desipramine and tramadol in a chronic mild stress model in mice are altered by yohimbine but not by pindolol
    Ipek Yalcin
    EA 3248 Psychobiologie des Emotions, Faculte des Sciences et Techniques, Universite Francois Rabelais, Parc Grandmont F 37200 Tours, France
    Eur J Pharmacol 514:165-74. 2005
    ....
  35. ncbi request reprint Central auditory processing in aging: the dichotic listening paradigm
    C Hommet
    CMRR région Centre et Médecine Interne Gériatrique, CHRU de Tours, Tours, France
    J Nutr Health Aging 14:751-6. 2010
    ..This study examines central auditory language processing with a dichotic listening task in right-handed old subjects according to their age...
  36. ncbi request reprint Behaviour in the elevated plus-maze predicts coping after subchronic mild stress in mice
    C Ducottet
    EA3248 Psychobiologie des Emotions, IFR 120, Imageries et explorations fonctionnelles, UFR des Sciences et Techniques, Parc de Grandmont, 37 200 Tours, France
    Physiol Behav 81:417-26. 2004
    ..e., BALB mice) displaying inhibited behaviours and less emotional mice (i.e., BL/6 mice) exhibiting few behavioural changes. Furthermore, emotional reactivity was increased in stressed mice compared with nonstressed ones...
  37. ncbi request reprint PTSD psychiatric patients exhibit a deficit in remembering
    Géraldine Tapia
    Universite Francois Rabelais, Departement de Psychologie, UMR CNRS 6215, Tours, France
    Memory 15:145-53. 2007
    ..These collective findings would suggest the possibility that a poor general ability in the formation of source memory may eventually be a common characteristic across different types of PTSD...
  38. doi request reprint Olfaction: a potential cognitive marker of psychiatric disorders
    Boriana Atanasova
    INSERM U 930 FRE CNRS 2448, Université François Rabelais Tours, Parc Grandmont, 37200 Tours, France
    Neurosci Biobehav Rev 32:1315-25. 2008
    ..Taken together, these data indicate that olfactory abnormalities might be a marker of psychiatric conditions, with a specific pattern for each disease...
  39. ncbi request reprint The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review
    Laetitia Prut
    EA3248, Psychobiologie des Emotions, Faculte des Sciences et Techniques, Universite Francois Rabelias, Parc de Grandmont Avenue Monge, 37200 Tours, France
    Eur J Pharmacol 463:3-33. 2003
    ....
  40. ncbi request reprint Effects of unpredictable chronic mild stress on anxiety and depression-like behavior in mice
    Yann S Mineur
    Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, 303 Belmont Street, Worcester, MA 01604, USA
    Behav Brain Res 175:43-50. 2006
    ..The goals of these experiments are to obtain a clearer behavioral profile of genetically/phenotypically distant mouse strains after UCMS treatment and to evaluate the limitations and strengths of the UCMS model in mice...
  41. ncbi request reprint Genetic basis of anxiety-like behaviour: a critical review
    Yan Clément
    Université Reims Champagne Ardenne, Taittinger, Reims Cedex, France
    Brain Res Bull 57:57-71. 2002
    ..We conclude that anxiety is a complex behaviour, underlined not only by genetic or environmental factors but also by multiple interactions between these two factors...
  42. ncbi request reprint Early life genetic, epigenetic and environmental factors shaping emotionality in rodents
    Andrew Holmes
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism NIAAA, National Institutes of Health, Bethesda, MD 20892 1256, Rockville, MD 20852, USA
    Neurosci Biobehav Rev 29:1335-46. 2005
    ....
  43. ncbi request reprint Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants
    Luca Santarelli
    Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Science 301:805-9. 2003
    ..These findings suggest that the behavioral effects of chronic antidepressants may be mediated by the stimulation of neurogenesis in the hippocampus...
  44. ncbi request reprint Agonistic behavior and unpredictable chronic mild stress in mice
    Yann S Mineur
    Brudnick Neuropsychiatric Research Institute, Worcester, Massachussetts 01606, USA
    Behav Genet 33:513-9. 2003
    ..Furthermore, UCMS increased aggression both in a resident-intruder test and between cage-mates. UCMS is therefore a valuable model of the problematic aggressive behavior seen in depressive patients...
  45. ncbi request reprint Strain differences in sucrose preference and in the consequences of unpredictable chronic mild stress
    Stéphanie Pothion
    Key Obs SA, Parc Technologique, 3 allée du Titane, 16 rue Leonard de Vinci, 45100 Orleans, France
    Behav Brain Res 155:135-46. 2004
    ..In the Y-maze, UCMS did not modify spontaneous alternation. These results show both an anhedonic-like and an amnesic effect of UCMS in CBA/H mice. They also reveal a difference of sensitivity to UCMS according to the strain of mice...
  46. doi request reprint Involvement of vasopressin in affective disorders
    Alexandre Surget
    EA3248 Psychobiologie des Emotions, Université François Rabelais Tours, UFR Sciences et Techniques, Parc Grandmont, F 37200 Tours, France
    Eur J Pharmacol 583:340-9. 2008
    ..Taken together, these data indicate that affective disorders may be related to excessive vasopressin function and consequently that a treatment with vasopressin receptor antagonists may be an effective treatment...
  47. doi request reprint Drug-dependent requirement of hippocampal neurogenesis in a model of depression and of antidepressant reversal
    Alexandre Surget
    U930, INSERM, Universite Francois Rabelais de Tours, Tours, France
    Biol Psychiatry 64:293-301. 2008
    ..We investigated causality between changes in hippocampal neurogenesis and the effects of both chronic stress and chronic ADs...