C Belzung

Summary

Country: France

Publications

  1. ncbi request reprint Measuring normal and pathological anxiety-like behaviour in mice: a review
    C Belzung
    EA 3248 Psychobiologie des Emotions, UFR Sciences et Techniques, Parc Grandmont, Avenue Monge, F 37200 Tours, France
    Behav Brain Res 125:141-9. 2001
  2. ncbi request reprint The genetic basis of the pharmacological effects of anxiolytics: a review based on rodent models
    C Belzung
    EA 3248 Psychobiologie des Emotions, UFR Sciences et Techniques, Parc Grandmont, F 37200 Tours, France
    Behav Pharmacol 12:451-60. 2001
  3. ncbi request reprint Behavioral and neurochemical changes following predatory stress in mice
    C Belzung
    EA 3248 Psychobiologie des Emotions, Faculte des Sciences et Techniques, Universite Francois Rabelais, Parc de Grandmont, 37200 Tours, France
    Neuropharmacology 41:400-8. 2001
  4. ncbi request reprint An investigation of the mechanisms responsible for acute fluoxetine-induced anxiogenic-like effects in mice
    C Belzung
    EA 3248 Psychobiologie des Emotions, UFR Sciences et Techniques, Tours, France
    Behav Pharmacol 12:151-62. 2001
  5. ncbi request reprint Beta-CCT, a selective BZ-omega1 receptor antagonist, blocks the anti-anxiety but not the amnesic action of chlordiazepoxide in mice
    C Belzung
    Laboratoire d Ethologie et de Pharmacologie du Comportement, UFR Sciences et Techniques, Tours, France
    Behav Pharmacol 11:125-31. 2000
  6. ncbi request reprint Absence of cocaine-induced place conditioning in serotonin 1B receptor knock-out mice
    C Belzung
    LEPCO, UFR Sciences et Techniques, Parc Grandmont, F 37200 Tours, France
    Pharmacol Biochem Behav 66:221-5. 2000
  7. ncbi request reprint Flumazenil induces benzodiazepine partial agonist-like effects in BALB/c but not C57BL/6 mice
    C Belzung
    Laboratoire d Ethologie et de Pharmacologie du Comportement, Faculte des Sciences, Parc Grandmont, 37200 Tours, France
    Psychopharmacology (Berl) 148:24-32. 2000
  8. ncbi request reprint Rodent models of anxiety-like behaviors: are they predictive for compounds acting via non-benzodiazepine mechanisms?
    C Belzung
    EA 3248 Psychobiologie des Emotions, Faculte des Sciences et Techniques, Universite de Tours, France
    Curr Opin Investig Drugs 2:1108-11. 2001
  9. ncbi request reprint Naloxone potentiates the anxiolytic but not the amnestic action of chlordiazepoxide in C57BL/6 mice
    C Belzung
    Laboratoire d Ethologie et de Pharmacologie du Comportement, Faculte des Sciences, Tours, France
    Behav Pharmacol 9:691-8. 1998
  10. ncbi request reprint Naloxone blocks anxiolytic-like effects of benzodiazepines in Swiss but not in Balb/c mice
    C Belzung
    Laboratoire d Ethologie et de Pharmacologie du Comportement, Faculté Sciences et Techniques, Tours, France
    Psychopharmacology (Berl) 132:195-201. 1997

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Measuring normal and pathological anxiety-like behaviour in mice: a review
    C Belzung
    EA 3248 Psychobiologie des Emotions, UFR Sciences et Techniques, Parc Grandmont, Avenue Monge, F 37200 Tours, France
    Behav Brain Res 125:141-9. 2001
    ..Inbred strains of mice, such as the BALB/c line, which exhibits spontaneously elevated anxiety appear to be a more suitable model of pathological anxiety...
  2. ncbi request reprint The genetic basis of the pharmacological effects of anxiolytics: a review based on rodent models
    C Belzung
    EA 3248 Psychobiologie des Emotions, UFR Sciences et Techniques, Parc Grandmont, F 37200 Tours, France
    Behav Pharmacol 12:451-60. 2001
    ..It is suggested that the strain differences in anxiety-like behaviour may be used as a tool in assaying anxiolytic activity of new drugs...
  3. ncbi request reprint Behavioral and neurochemical changes following predatory stress in mice
    C Belzung
    EA 3248 Psychobiologie des Emotions, Faculte des Sciences et Techniques, Universite Francois Rabelais, Parc de Grandmont, 37200 Tours, France
    Neuropharmacology 41:400-8. 2001
    ..Taken together, these findings indicate that the exposure of mice to unavoidable predatory stimuli is associated with behavioral and neurochemical changes consistent with increased anxiety...
  4. ncbi request reprint An investigation of the mechanisms responsible for acute fluoxetine-induced anxiogenic-like effects in mice
    C Belzung
    EA 3248 Psychobiologie des Emotions, UFR Sciences et Techniques, Tours, France
    Behav Pharmacol 12:151-62. 2001
    ....
  5. ncbi request reprint Beta-CCT, a selective BZ-omega1 receptor antagonist, blocks the anti-anxiety but not the amnesic action of chlordiazepoxide in mice
    C Belzung
    Laboratoire d Ethologie et de Pharmacologie du Comportement, UFR Sciences et Techniques, Tours, France
    Behav Pharmacol 11:125-31. 2000
    ..These results are in agreement with previous studies using selective BZ-omega1 agonists, and thus provide further evidence that BZ-omega1 receptors may be involved in the anxiolytic but not in the amnesic effects of BZ agonists...
  6. ncbi request reprint Absence of cocaine-induced place conditioning in serotonin 1B receptor knock-out mice
    C Belzung
    LEPCO, UFR Sciences et Techniques, Parc Grandmont, F 37200 Tours, France
    Pharmacol Biochem Behav 66:221-5. 2000
    ..As other studies showed that 5-HT1B knock-out mice self-administer cocaine, these results suggest a dissociation between the psychologic state linked to self-administration and the one measured in conditioned place preference...
  7. ncbi request reprint Flumazenil induces benzodiazepine partial agonist-like effects in BALB/c but not C57BL/6 mice
    C Belzung
    Laboratoire d Ethologie et de Pharmacologie du Comportement, Faculte des Sciences, Parc Grandmont, 37200 Tours, France
    Psychopharmacology (Berl) 148:24-32. 2000
    ..Some anxiety disorders may be treated in a different way than normal anxiety...
  8. ncbi request reprint Rodent models of anxiety-like behaviors: are they predictive for compounds acting via non-benzodiazepine mechanisms?
    C Belzung
    EA 3248 Psychobiologie des Emotions, Faculte des Sciences et Techniques, Universite de Tours, France
    Curr Opin Investig Drugs 2:1108-11. 2001
    ....
  9. ncbi request reprint Naloxone potentiates the anxiolytic but not the amnestic action of chlordiazepoxide in C57BL/6 mice
    C Belzung
    Laboratoire d Ethologie et de Pharmacologie du Comportement, Faculte des Sciences, Tours, France
    Behav Pharmacol 9:691-8. 1998
    ..Naloxone elicited no intrinsic action in any of these behavioural models. It can be concluded that naloxone potentiates the anxiolytic but not the amnestic action of chlordiazepoxide...
  10. ncbi request reprint Naloxone blocks anxiolytic-like effects of benzodiazepines in Swiss but not in Balb/c mice
    C Belzung
    Laboratoire d Ethologie et de Pharmacologie du Comportement, Faculté Sciences et Techniques, Tours, France
    Psychopharmacology (Berl) 132:195-201. 1997
    ..Therefore, the ability of naloxone to reverse anxiolytic effects does not hold for all strains of mice...
  11. ncbi request reprint Naloxone potentiates the effects of subeffective doses of anxiolytic agents in mice
    C Belzung
    Laboratoire d Ethologie et de Pharmacologie du Comportement, Faculte des Sciences, Tours, France
    Eur J Pharmacol 323:133-6. 1997
    ..5 mg/kg, chlordiazepoxide 5 mg/kg and buspirone 4 mg/kg). Naloxone alone (10 mg/kg) had no intrinsic effect. These data suggest that naloxone is able to potentiate the effects of anti-anxiety agents...
  12. ncbi request reprint Correlations between behaviours in the elevated plus-maze and sensitivity to unpredictable subchronic mild stress: evidence from inbred strains of mice
    C Ducottet
    EA3248 Psychobiologie des Emotions, UFR des Sciences et Techniques, Parc de Grandmont, 37200 Tours, France
    Behav Brain Res 156:153-62. 2005
    ..These results suggest that anxiety may be a factor contributing, among others, to the susceptibility to depressive-like behaviours...
  13. ncbi request reprint Naloxone potentiates anxiolytic-like actions of diazepam, pentobarbital and meprobamate but not those of Ro19-8022 in the rat
    C Belzung
    Laboratoire d Ethologie et de Pharmacologie du Comportement, Faculte des Sciences, Universite de Tours, Tours, France
    Eur J Pharmacol 394:289-94. 2000
    ..Another possibility is that naloxone blocks opioid effects on adenosinergic systems...
  14. ncbi request reprint Behaviour in the elevated plus-maze predicts coping after subchronic mild stress in mice
    C Ducottet
    EA3248 Psychobiologie des Emotions, IFR 120, Imageries et explorations fonctionnelles, UFR des Sciences et Techniques, Parc de Grandmont, 37 200 Tours, France
    Physiol Behav 81:417-26. 2004
    ..e., BALB mice) displaying inhibited behaviours and less emotional mice (i.e., BL/6 mice) exhibiting few behavioural changes. Furthermore, emotional reactivity was increased in stressed mice compared with nonstressed ones...
  15. ncbi request reprint Anxiolytic-like effects of meprobamate. Interactions with an opiate antagonist in Swiss and BALB/c mice
    C Belzung
    Laboratoire d Ethologie et Pharmacologie du Comportement, Faculte des Sciences, Universite de Tours, Tours, France
    Pharmacol Biochem Behav 65:465-74. 2000
    ..This suggests that the mechanisms behind naloxone's blockade of anxiolytic-like effects are independent from those behind its potentiation of such effects...
  16. ncbi request reprint Emotional reactivity in mice, a case of nongenetic heredity?
    F Calatayud
    EA 3248 Psychobiologie des Emotions, Faculte de Sciences et Techniques, Parc de Grandmont, Tours 37200, France
    Physiol Behav 74:355-62. 2001
    ..In the light/dark box, no difference has been found between the two hybrids. Moreover, the mother's influence is greater in males than in females...
  17. ncbi request reprint Further pharmacological validation of the BALB/c neophobia in the free exploratory paradigm as an animal model of trait anxiety
    C Belzung
    Laboratoire d Ethologie et de Pharmacologie du Comportement, UFR Sciences et Techniques, Tours, France
    Behav Pharmacol 8:541-8. 1997
    ..Because of its chronicity, this paradigm may model generalized anxiety, a pathology that has been suggested to overlap trait anxiety...
  18. pmc Antidepressants recruit new neurons to improve stress response regulation
    A Surget
    U930 Imaging and Brain, INSERM, Tours, France
    Mol Psychiatry 16:1177-88. 2011
    ....
  19. ncbi request reprint Rearing environmental enrichment in two inbred strains of mice: 1. Effects on emotional reactivity
    P Chapillon
    Universite de Rouen, Faculte des Sciences, Laboratoire de Neurobiologie de l Apprentissage, Mont Saint Aignan, France
    Behav Genet 29:41-6. 1999
    ..In contrast, the level of trait anxiety of the B6 mice was not modified. The results were discussed in relation to possible CNS modifications, especially in the limbic system...
  20. ncbi request reprint The role of subtypes of the opioid receptor in the anxiolytic action of chlordiazepoxide
    A Agmo
    Laboratoire de Psychophysiologie, Faculte des Sciences, Universite de Tours, France
    Neuropharmacology 37:223-32. 1998
    ..None of the antagonists affected plus-maze behavior when administered alone. It was concluded that the mu and kappa receptors are important for the anxiolytic-like actions of chlordiazepoxide in the elevated plus maze...
  21. ncbi request reprint Susceptibility to subchronic unpredictable stress is related to individual reactivity to threat stimuli in mice
    C Ducottet
    EA3248 Psychobiologie des Emotions, UFR des Sciences et Techniques, Parc de Grandmont, 37 200 Tours, France
    Behav Brain Res 155:291-9. 2004
    ..These results are discussed regarding their relevance for the understanding of aetiologies of depressive illnesses...
  22. ncbi request reprint Neuropeptides in psychiatric diseases: an overview with a particular focus on depression and anxiety disorders
    C Belzung
    EA3248, Psychobiologie des Emotions, UFR Sciences et Techniques, Parc Grandmont, 37200 Tours, France
    CNS Neurol Disord Drug Targets 5:135-45. 2006
    ..At the systemic level, a neuropeptide can play a direct role in the expression of a symptom of the disease. This is illustrated by different examples...
  23. pmc Open questions in current models of antidepressant action
    A Tanti
    INSERM U 930, Université François Rabelais Tours, UFR Sciences et Techniques, Parc Grandmont, Tours, France
    Br J Pharmacol 159:1187-200. 2010
    ....
  24. ncbi request reprint Central auditory processing in aging: the dichotic listening paradigm
    C Hommet
    CMRR région Centre et Médecine Interne Gériatrique, CHRU de Tours, Tours, France
    J Nutr Health Aging 14:751-6. 2010
    ..This study examines central auditory language processing with a dichotic listening task in right-handed old subjects according to their age...
  25. ncbi request reprint The effects of the lurcher mutation on object localization, T-maze discrimination, and radial arm maze tasks
    C Belzung
    Universite de Tours, EA Psychobiologie des émotions, Tours, France
    Behav Genet 31:151-5. 2001
    ..These results indicate that trial-independent tasks and reference memory tasks using cognitive mapping may be particularly vulnerable to cerebellar degeneration...
  26. ncbi request reprint Ethological validation and the assessment of anxiety-like behaviours: methodological comparison of classical analyses and structural approaches
    F Calatayud
    INRA IRGM BP27 31326 Castanet Tolosan, France
    Behav Processes 67:195-206. 2004
    ..We defend the idea that the meaning of a behavioural variable should be restricted to the general context where it arose. Theoretical propositions and methodological options are discussed...
  27. ncbi request reprint n-3 polyunsaturated fatty acid supplementation reverses stress-induced modifications on brain monoamine levels in mice
    S Vancassel
    Unité de Nutrition et Régulation Lipidique des Fonctions Cérébrales, Institut National de la Recherche Agronomique, Domaine de Vilvert, 78352 Jouy en Josas Cedex, France
    J Lipid Res 49:340-8. 2008
    ..These findings showed that supplementation in n-3 long-chain PUFAs might reverse certain effects of UCMS in cerebral structures involved in stress-related behaviors...
  28. ncbi request reprint Functional implications of decreases in neurogenesis following chronic mild stress in mice
    Y S Mineur
    Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, 303 Belmont Street, Worcester, MA 01604, USA
    Neuroscience 150:251-9. 2007
    ..However, the specific results were strongly dependent on strain and sex so that there does not appear to be a direct causative relationship between the deficits in neurogenesis and behavior...
  29. pmc Lack of serotonin1B receptor expression leads to age-related motor dysfunction, early onset of brain molecular aging and reduced longevity
    E Sibille
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Psychiatry 12:1042-56, 975. 2007
    ....
  30. ncbi request reprint Decreased GABAA-receptor clustering results in enhanced anxiety and a bias for threat cues
    F Crestani
    Institute of Pharmacology, Swiss Federal Institute of Technology ETH and University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Nat Neurosci 2:833-9. 1999
    ..This model implicates GABAA-receptor dysfunction in patients as a causal predisposition to anxiety disorders...
  31. ncbi request reprint Emotional reactivity in mice may not be inherited but influenced by parents
    F Calatayud
    INRA IRGM, BP 27, 31326 Castanet Tolosan, France
    Physiol Behav 80:465-74. 2004
    ..A possible explanation is that emotional reactivity is induced by maternal behaviour rather than transmitted by the parents...
  32. ncbi request reprint 5-HT1B receptor knock out--behavioral consequences
    S Ramboz
    Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Behav Brain Res 73:305-12. 1996
    ....
  33. ncbi request reprint Prucalopride and donepezil act synergistically to reverse scopolamine-induced memory deficit in C57Bl/6j mice
    M Cachard-Chastel
    University of Paris Sud, EA3544, Fac Pharmacie, F92296 Châtenay Malabry Cedex, France
    Behav Brain Res 187:455-61. 2008
    ..Thus, a drug polytherapy could be interesting not only to enhance cognitive performance and decrease drawbacks but also to get the best action in each brain region...