Pierre Bedossa

Summary

Country: France

Publications

  1. pmc Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity
    Corneliu Henegar
    INSERM, UMR S 872, Les Cordeliers, Eq, 7 Nutriomique and Eq, 13, Paris, F 75006 France
    Genome Biol 9:R14. 2008
  2. ncbi request reprint Approaches for treatment of liver fibrosis in chronic hepatitis C
    Pierre Bedossa
    Department of Pathology, Service d Anatomie Pathologique, Hopital Bicetre, Universite Paris XI, 78 rue du General Leclerc, 94725 Le Kremlin Bicêtre, France
    Clin Liver Dis 7:195-210. 2003
  3. ncbi request reprint Liver extracellular matrix in health and disease
    Pierre Bedossa
    Service d Anatomie Pathologique, CNRS FRE2443, Hopital de Bicetre, 78 Avenue Géneral Leclerc, 94275 Le Kremlin Bicetre, France
    J Pathol 200:504-15. 2003
  4. ncbi request reprint [Regression of hepatic fibrosis physiopathological aspects and clinical reality]
    Pierre Bedossa
    Service d Anatomie Pathologique, CNRS ESA 8067, Hôpital Bicêtre Le Kremlin Bicêtre 94
    Presse Med 32:704-10. 2003
  5. ncbi request reprint Sampling variability of liver fibrosis in chronic hepatitis C
    Pierre Bedossa
    Service d Anatomie Pathologique, Hopital Bicetre, Le Kremlin Bicetre, France
    Hepatology 38:1449-57. 2003
  6. ncbi request reprint Images in hepatology. Telangiectatic adenoma: a variant of hepatocellular adenoma
    Pierre Bedossa
    Hopital Beaujon, Service d Anatomie Pathologique
    Ann Hepatol 3:163. 2004
  7. ncbi request reprint Dystroglycan expression in hepatic stellate cells: role in liver fibrosis
    Pierre Bedossa
    Service d Anatomie Pathologique, Hopital de Bicetre, Universite Paris Sud, France
    Lab Invest 82:1053-61. 2002
  8. doi request reprint Impact of peginterferon and ribavirin therapy on hepatocellular carcinoma: incidence and survival in hepatitis C patients with advanced fibrosis
    Ana Carolina Cardoso
    Service d Hepatologie, Hopital Beaujon, AP HP, INSERM U773 CRB3, Universite Denis Diderot Paris7, 100 Boulevard du General Leclerc, 92110 Clichy, France
    J Hepatol 52:652-7. 2010
  9. doi request reprint Early serum HBsAg drop: a strong predictor of sustained virological response to pegylated interferon alfa-2a in HBeAg-negative patients
    Rami Moucari
    Service d Hepatologie, Hopital Beaujon, Clichy, France
    Hepatology 49:1151-7. 2009
  10. doi request reprint Insulin resistance in chronic hepatitis C: association with genotypes 1 and 4, serum HCV RNA level, and liver fibrosis
    Rami Moucari
    AP HP, Hopital Beaujon, Service d Hepatologie, Clichy F 92110, France
    Gastroenterology 134:416-23. 2008

Detail Information

Publications89

  1. pmc Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity
    Corneliu Henegar
    INSERM, UMR S 872, Les Cordeliers, Eq, 7 Nutriomique and Eq, 13, Paris, F 75006 France
    Genome Biol 9:R14. 2008
    ..However, the overall importance of these alterations, and their long-term impact on the metabolic functions of the WAT and on its morphology, remain unclear...
  2. ncbi request reprint Approaches for treatment of liver fibrosis in chronic hepatitis C
    Pierre Bedossa
    Department of Pathology, Service d Anatomie Pathologique, Hopital Bicetre, Universite Paris XI, 78 rue du General Leclerc, 94725 Le Kremlin Bicêtre, France
    Clin Liver Dis 7:195-210. 2003
    ..It is likely that in the future, besides viral eradication, another treatment goal in chronic HCV infection will be to reverse existing fibrosis, but considerable work is necessary before making this a reality...
  3. ncbi request reprint Liver extracellular matrix in health and disease
    Pierre Bedossa
    Service d Anatomie Pathologique, CNRS FRE2443, Hopital de Bicetre, 78 Avenue Géneral Leclerc, 94275 Le Kremlin Bicetre, France
    J Pathol 200:504-15. 2003
    ..In addition to these experimental data, experience from chronic hepatitis C now allows the development of new concepts and perspectives such as liver fibrosis regression and antifibrotic therapies...
  4. ncbi request reprint [Regression of hepatic fibrosis physiopathological aspects and clinical reality]
    Pierre Bedossa
    Service d Anatomie Pathologique, CNRS ESA 8067, Hôpital Bicêtre Le Kremlin Bicêtre 94
    Presse Med 32:704-10. 2003
    ..Although these treatments have shown efficacy on experimental models of fibrosis, to date, there are no published results formally confirming the efficacy and safety of these treatments in man...
  5. ncbi request reprint Sampling variability of liver fibrosis in chronic hepatitis C
    Pierre Bedossa
    Service d Anatomie Pathologique, Hopital Bicetre, Le Kremlin Bicetre, France
    Hepatology 38:1449-57. 2003
    ..Sampling variability becomes a major limitation when using more accurate methods such as automated image analysis...
  6. ncbi request reprint Images in hepatology. Telangiectatic adenoma: a variant of hepatocellular adenoma
    Pierre Bedossa
    Hopital Beaujon, Service d Anatomie Pathologique
    Ann Hepatol 3:163. 2004
  7. ncbi request reprint Dystroglycan expression in hepatic stellate cells: role in liver fibrosis
    Pierre Bedossa
    Service d Anatomie Pathologique, Hopital de Bicetre, Universite Paris Sud, France
    Lab Invest 82:1053-61. 2002
    ..Dystroglycan interaction with laminin should be implicated in the concentration of pericellular laminin and in the constitution of a perisinusoidal basement membrane during liver fibrosis...
  8. doi request reprint Impact of peginterferon and ribavirin therapy on hepatocellular carcinoma: incidence and survival in hepatitis C patients with advanced fibrosis
    Ana Carolina Cardoso
    Service d Hepatologie, Hopital Beaujon, AP HP, INSERM U773 CRB3, Universite Denis Diderot Paris7, 100 Boulevard du General Leclerc, 92110 Clichy, France
    J Hepatol 52:652-7. 2010
    ..We assessed the influence of combination therapy on the risk of HCC, liver-related complications (ascites, variceal bleeding), and liver-related death (or liver transplantation)...
  9. doi request reprint Early serum HBsAg drop: a strong predictor of sustained virological response to pegylated interferon alfa-2a in HBeAg-negative patients
    Rami Moucari
    Service d Hepatologie, Hopital Beaujon, Clichy, France
    Hepatology 49:1151-7. 2009
    ..HBsAg loss was observed in three patients, all with SVR...
  10. doi request reprint Insulin resistance in chronic hepatitis C: association with genotypes 1 and 4, serum HCV RNA level, and liver fibrosis
    Rami Moucari
    AP HP, Hopital Beaujon, Service d Hepatologie, Clichy F 92110, France
    Gastroenterology 134:416-23. 2008
    ..Our study was designed to test the association between insulin resistance (IR) and hepatitis C virus (HCV) genotypes, serum HCV RNA level and liver fibrosis stage in a large prospective cohort of chronic hepatitis C (CHC) patients...
  11. doi request reprint Heterogeneity of tumor prognostic markers: a reproducibility study applied to liver metastases of pancreatic endocrine tumors
    Anne Couvelard
    Department of Pathology, University of Paris 7, Assistance Publique Hopitaux de Paris, Beaujon Hospital, Clichy, France
    Mod Pathol 22:273-81. 2009
    ..Sampling variability should be taken into consideration as a potential limitation to the assessment of prognostic and therapeutic markers in biopsy samples from metastatic pancreatic endocrine tumors...
  12. ncbi request reprint Virological response at 4 weeks to predict outcome of hepatitis C treatment with pegylated interferon and ribavirin
    Michelle Martinot-Peignoux
    INSERM, U 773, Centre de Recherche Biomedicale Bichat Beaujon CRB3, Universite Paris VII, Hopital Beaujon, Clichy, France
    Antivir Ther 14:501-11. 2009
    ....
  13. ncbi request reprint Telangiectatic focal nodular hyperplasia: a variant of hepatocellular adenoma
    Valerie Paradis
    Service d Anatomie Pathologique, Hopital Beaujon, Clichy, France
    Gastroenterology 126:1323-9. 2004
    ..Therefore, the aim of the present study was to reconsider the classification of telangiectatic FNH with the help of a molecular approach...
  14. pmc Significant gene expression differences in histologically "Normal" liver biopsies: Implications for control tissue
    Tarik Asselah
    Service d Hépatologie and Institut National de la Santé et de la Recherche Médicale INSERM U733, CRB3, Universite Paris Diderot, Assistance Publique Hopitaux de Paris, Hopital Beaujon, Clichy, France
    Hepatology 48:953-62. 2008
    ..In chronic hepatitis C liver samples, a lower or higher expression of a IL8 was found depending on whether the controls were obtained percutaneously or surgically...
  15. ncbi request reprint Quantitative RT-PCR in cirrhotic nodules reveals gene expression changes associated with liver carcinogenesis
    Magali Colombat
    Service d Anatomie Pathologique, Hopital Beaujon, Clichy, France
    J Pathol 201:260-7. 2003
    ..The decrease in the expression level of one of these genes, LYVE1, was associated with monoclonality in cirrhotic nodules...
  16. doi request reprint Hepatocellular carcinomas in patients with metabolic syndrome often develop without significant liver fibrosis: a pathological analysis
    Valerie Paradis
    Service d Anatomie Pathologique, Hopital Beaujon, Clichy, France
    Hepatology 49:851-9. 2009
    ..In addition, some of them arise through malignant transformation of a preexisting liver cell adenoma...
  17. doi request reprint Eradication of hepatitis C virus in patients successfully treated for chronic hepatitis C
    Sarah Maylin
    Universite Paris VII, Hopital Beaujon, Clichy, France
    Gastroenterology 135:821-9. 2008
    ..It is unclear whether hepatitis C virus (HCV) is eradicated in patients with chronic hepatitis C who achieved a sustained virologic response (SVR)...
  18. doi request reprint Overexpression of the oxygen sensors PHD-1, PHD-2, PHD-3, and FIH Is associated with tumor aggressiveness in pancreatic endocrine tumors
    Anne Couvelard
    Department of Pathology, University Paris 7, Clichy, France
    Clin Cancer Res 14:6634-9. 2008
    ..e., prolyl hydroxylase domain proteins (PHD)-1, PHD-2, PHD-3, and FIH in pancreatic endocrine tumors (PET)...
  19. doi request reprint Proteomic assessment of markers for malignancy in the mucus of intraductal papillary mucinous neoplasms of the pancreas
    Olivier Corcos
    Service de gastroentérologie et d assistance nutritive, Hopital Beaujon, France
    Pancreas 41:169-74. 2012
    ..The aims of this study were to look for candidate protein profiles in IPMN mucus according to histological grade, using a differential proteomic technique, and to highlight protein peaks associated with malignant transformation...
  20. doi request reprint Direct comparison of diagnostic performance of transient elastography in patients with chronic hepatitis B and chronic hepatitis C
    Ana Carolina Cardoso
    Service d Hépatologie and INSERM U773 CRB3, Hopital Beaujon, APHP, University of Paris 7, Clichy, France
    Liver Int 32:612-21. 2012
    ..A secondary analysis was performed to assess whether or not alanine aminotransferase (ALT) levels would impact on the accuracy of TE...
  21. doi request reprint Biological and prognostic relevance of mitogen-activated protein kinases in pancreatic adenocarcinoma
    Adriana Handra-Luca
    Service d Anatomie Pathologique, APHP Groupe Hospitalier Universitaire Nord, Bobigny, France
    Pancreas 41:416-21. 2012
    ....
  22. pmc SCG10 expression on activation of hepatic stellate cells promotes cell motility through interference with microtubules
    Valerie Paradis
    Department of Pathology, INSERM U773, the Serviced Hépatologie, Beaujon Hospital, AP HP, University Paris Diderot, Paris, France
    Am J Pathol 177:1791-7. 2010
    ..SCG10 may represent a potential molecular target for anti-fibrosis therapies...
  23. ncbi request reprint Evidence for a role of nonalcoholic steatohepatitis in hepatitis C: a prospective study
    Pierre Bedossa
    Service d Anatomie Pathologique, CNRS UMR 8149, Clichy, France
    Hepatology 46:380-7. 2007
    ..In multivariate analysis, triglyceride and HDL cholesterol were predictors of NASH in patients with genotype 1, whereas in patients with genotype 3, AST was the only predictor...
  24. doi request reprint Accuracy and disagreement of computed tomography and magnetic resonance imaging for the diagnosis of small hepatocellular carcinoma and dysplastic nodules: role of biopsy
    Thomas Sersté
    Assistance Publique Hopitaux de Paris, APHP Service d Hépatologie, Hopital Beaujon, Clichy, France
    Hepatology 55:800-6. 2012
    ..There was a disagreement regarding imaging findings between CT and MRI in 21 of 74 (28%) patients and no washout on both examinations in 23 of 74 patients (31%). In these 44 patients, liver biopsy provided an initial accurate diagnosis...
  25. doi request reprint Molecular profiling of pancreatic neuroendocrine tumors in sporadic and Von Hippel-Lindau patients
    Daniela Speisky
    Service d Anatomie Pathologique, Service de Gastroentérologie Pancréatologie, Service de Chirurgie Hépatique et Pancréatique, AP HP, Hopital Beaujon, Clichy, France
    Clin Cancer Res 18:2838-49. 2012
    ..Our aim was to characterize by molecular quantitative analysis a panel of molecules implicated in the VHL pathway and in tumor progression in the PanNET of patients with VHL...
  26. doi request reprint High rates of HBsAg seroconversion in HBeAg-positive chronic hepatitis B patients responding to interferon: a long-term follow-up study
    Rami Moucari
    AP HP, Hopital Beaujon, Service d Hepatologie, 100 Boulevard du General Leclerc, 92100 Clichy, France
    J Hepatol 50:1084-92. 2009
    ..To assess the HBsAg seroconversion rate and its impact on the long-term outcome in chronic hepatitis B patients treated with conventional interferon, and to analyze the serum HBsAg concentration prior to seroconversion...
  27. pmc Changes in autophagic response in patients with chronic hepatitis C virus infection
    Pierre Emmanuel Rautou
    Service d Hepatologie, Hopital Beaujon, Assistance Publique Hopitaux de Paris, Clichy, France
    Am J Pathol 178:2708-15. 2011
    ..Neither genotype nor viral load influenced the autophagy level. In conclusion, autophagy is altered in hepatocytes from CHC patients, likely due to a blockade of the last step of the autophagic process...
  28. ncbi request reprint A quantitative gene expression study suggests a role for angiopoietins in focal nodular hyperplasia
    Valerie Paradis
    Service d Anatomie Pathologique and Service de Chirurgie, Hopital Beaujon, Clichy, France
    Gastroenterology 124:651-9. 2003
    ..To gain insight into the pathogenesis of FNH, we performed a large-scale quantitative study of gene expression in FNH...
  29. doi request reprint Changing trends in malignant transformation of hepatocellular adenoma
    Olivier Farges
    Department of Hepato biliary Surgery, Pôle des Maladies de l Appareil Digestif, Hopital Beaujon, Assistance Publique Hopitaux de Paris, Universite Paris 7, Clichy, France
    Gut 60:85-9. 2011
    ..HCA with malignant transformation is, however, an ill-defined entity thought to be an anecdotic pathway to HCC. The objective of this study was to characterise malignancy occurring within HCA...
  30. doi request reprint The expression of the hypoxia markers CA9 and CXCR4 is correlated with survival in patients with neuroendocrine tumours of the ileum
    Lydia Deschamps
    Service d Anatomie Pathologique, CRB3 INSERM U773, Hopital Beaujon, Clichy, France
    Neuroendocrinology 95:214-22. 2012
    ..Our aim was to investigate the expression of these markers in a series of patients with an ileal neuroendocrine tumour (IET) at various stages of tumorigenesis...
  31. ncbi request reprint Identification of potential therapeutic targets by gene-expression profiling in pancreatic endocrine tumors
    Anne Couvelard
    Department of Pathology, Beaujon Hospital, Assistance Publique Hopitaux de Paris AP HP, Clichy, France
    Gastroenterology 131:1597-610. 2006
    ..The aim of this study was to characterize PET gene expression by complementary DNA (cDNA) microarray and identify specific differences in gene-expression profiles between nonmetastatic and metastatic tumors...
  32. ncbi request reprint [Fibrosis in chronic hepatitis C infection: mechanisms and cofactors]
    Pierre Bedossa
    Service d Anatomie Pathologique, CNRS ESA8067, Hopital de Bicetre, Le Kremlin Bicetre
    Gastroenterol Clin Biol 26:B163-7. 2002
  33. ncbi request reprint Telangiectatic adenoma: an entity associated with increased body mass index and inflammation
    Valerie Paradis
    Service d Anatomie Pathologique, Hopital Beaujon, Clichy, France
    Hepatology 46:140-6. 2007
    ..Serum biomarkers of inflammation were increased in 90% of patients (19 of 22). After surgical resection, inflammatory marker levels returned to normal values in all patients tested...
  34. doi request reprint Pathology analysis reveals that dysplastic pancreatic ductal lesions are frequent in patients with hereditary pancreatitis
    Vinciane Rebours
    Pôle des Maladies de l Appareil Digestif, Service de Gastroentérologie Pancréatologie, Hopital Beaujon, AP HP, Paris, Clichy, France
    Clin Gastroenterol Hepatol 8:206-12. 2010
    ....
  35. doi request reprint [Pathology of cholangiocarcinoma]
    Nathalie Guedj
    Hopital Beaujon, Clichy, France
    Ann Pathol 30:455-63. 2010
    ..In this chapter, we will describe the different gross features and histological characteristic of CC and will detail the major histopronostic criteria of these tumors...
  36. doi request reprint Comparative protein expression profiles of hilar and peripheral hepatic cholangiocarcinomas
    Nathalie Guedj
    Department of Pathology, Beaujon Hospital, 100 Boulevard du General Leclerc, 92118 Clichy, France
    J Hepatol 51:93-101. 2009
    ..Hepatic cholangiocarcinomas are tumors with poor prognosis and with increasing incidence worldwide. The aim of the study was to compare morphological features and protein profiles of hilar and peripheral cholangiocarcinomas...
  37. doi request reprint Predictors of tumor response after preoperative chemoradiotherapy for rectal adenocarcinomas
    Nathalie Guedj
    Department of Pathology, Beaujon Hospital, 92110 Clichy, France
    Hum Pathol 42:1702-9. 2011
    ..This study highlighted the importance of predictive criteria to chemoradiotherapy response in proposing to selected patients an alternative treatment (eg, local resection) to more radical surgery...
  38. ncbi request reprint The role of replicative senescence in chronic allograft nephropathy
    Sophie Ferlicot
    Department of Pathology, Bicetre Hospital, Universite Paris Sud, Le Kremlin Bicetre Cedex, France
    Hum Pathol 34:924-8. 2003
    ..These results suggest that replicative senescence is a mechanism that might be involved in the development of CAN. The age of the donor appears to be the major determinant factor in replicative senescence...
  39. ncbi request reprint Effects and regulation of connective tissue growth factor on hepatic stellate cells
    Valerie Paradis
    Service d Anatomie Pathologique, Hopital de Bicetre, Le Kremlin Bicetre, France
    Lab Invest 82:767-74. 2002
    ..In conclusion, this study extends the role of CTGF in HSC activation and suggests that CTGF up-regulation might be a central pathway during HSC activation...
  40. doi request reprint [Pancreatic perivascular epithelioid cell tumor (PEComa)]
    Martine Perigny
    Service d Anatomie Pathologique, Hopital Beaujon, AP HP, Universite Paris 7 Denis Diderot, 100, boulevard du General Leclerc, 92110 Clichy, France
    Ann Pathol 28:138-42. 2008
    ..These features were consistent with a PEComa. Pancreatic PEComas are rare, but should be included in the differential diagnostic of pancreatic clear cells tumors or pancreatic spindle- and epithelioid-cells tumors...
  41. doi request reprint [Sclerosing mesenteritis: can it be a IgG4 dysimmune disease?]
    Hicham Belghiti
    Service d Anatomie Pathologique, Hopital Beaujon, AP HP, 92118 Clichy Cedex, France
    Ann Pathol 29:468-74. 2009
    ..The pathogenesis is unknown until now. Hypothesis of a dysimmune disorder is advocated. Our purpose was to find histological basis to assert this hypothesis...
  42. ncbi request reprint Efficacy of peginterferon alpha-2b in chronic hepatitis delta: relevance of quantitative RT-PCR for follow-up
    Corinne Castelnau
    Service d Hepatologie, Hopital Beaujon, AP HP INSERM U773 CRB3, Clichy, and Université Paris 13, Bobigny, France
    Hepatology 44:728-35. 2006
    ..The follow-up of HDV-RNA levels during therapy, which allows the differentiation of various profiles of virological responses, improves treatment monitoring...
  43. doi request reprint Obliterative portal venopathy: portal hypertension is not always present at diagnosis
    Dominique Cazals-Hatem
    Service d Anatomie Pathologique, Hôpital Beaujon AP HP, Clichy and Institut National de la Santé et de la Recherche Médicale U773, Centre de Recherche Biomedicale Bichat Beaujon CRB3, Universite Denis Diderot Paris 7, France
    J Hepatol 54:455-61. 2011
    ..Previous studies on obliterative portal venopathy (OPV) have been biased due to the selection of patients with non-cirrhotic portal hypertension. The aim of this study was to clarify the characteristics of OVP diagnosed by liver biopsy...
  44. doi request reprint Algorithm for immediate cytologic diagnosis of hepatic tumors
    Lawrence F Pupulim
    Service de Radiologie, Hopital Beaujon, Assistance Publique des Hopitaux de Paris, Universite Paris, 100, Blvd du Général Leclerc, 92110 Clichy, France
    AJR Am J Roentgenol 190:W208-12. 2008
    ..The purpose of this study was to analyze the diagnostic accuracy of on-site cytologic assessment compared with definitive cytologic examination in the detection and correct subtyping of malignant hepatic lesions...
  45. ncbi request reprint CD10 expression in pancreatic endocrine tumors: correlation with prognostic factors and survival
    Lydia Deschamps
    Department of Pathology, AP HP, Beaujon Hospital, 92110 Clichy, France
    Hum Pathol 37:802-8. 2006
    ..In conclusion, CD10 is expressed in a subset of PETs and correlates with histopathologic indicators of poor outcome, suggesting a role for this molecule in tumorigenesis and prognostic analysis...
  46. ncbi request reprint Measurement of telomere length on tissue sections using quantitative fluorescence in situ hybridization (Q-FISH)
    Sophie Ferlicot
    Services d anatomie pathologique, Hopital de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre cedex, France
    J Pathol 200:661-6. 2003
    ..It is an easy, accurate, and reproducible in situ method for assessing telomeres in the context of cell type and tissue architecture...
  47. doi request reprint Plasma proteome to look for diagnostic biomarkers of early bacterial sepsis after liver transplantation: a preliminary study
    Catherine Paugam-Burtz
    Department of Anesthesiology and Critical Care, University Hospital, Assistance Publique Hopitaux de Paris, Hopital Beaujon, Bd du Général Leclerc, Clichy, France
    Anesthesiology 112:926-35. 2010
    ..This study used plasma profiling coupling Proteinchip array with surface-enhanced laser desorption ionization time-of-fly mass spectrometry to search for biomarkers of postoperative sepsis in patients who underwent liver transplantation...
  48. doi request reprint The role of immunohistochemistry in idiopathic chronic intestinal pseudoobstruction (CIPO): a case-control study
    Aurelien Amiot
    Pôle des Maladies de l Appareil Digestif, Unité de Gastroentérologie et d assistance Nutritive, Hopital Beaujon, Clichy, France
    Am J Surg Pathol 33:749-58. 2009
    ..Although the histology usually permits to highlight pathologic abnormalities of CIPO, it fails in almost a third of cases. The yield of a systematic immunohistochemistry needs to be evaluating...
  49. doi request reprint Diagnostic accuracy of FibroScan and comparison to liver fibrosis biomarkers in chronic viral hepatitis: a multicenter prospective study (the FIBROSTIC study)
    Francoise Degos
    APHP, Hopital Beaujon, Hepatology Dept, INSERM U 773, Clichy, France
    J Hepatol 53:1013-21. 2010
    ..We assessed and compared the accuracy of FibroScan® and that of the main biomarkers used for predicting cirrhosis and significant fibrosis (METAVIR ≥ F2) in patients with chronic viral hepatitis...
  50. ncbi request reprint Serum proteome to predict virologic response in patients with hepatitis C treated by pegylated interferon plus ribavirin
    Valerie Paradis
    Service d anatomie pathologie, Hopital Beaujon, and CNRS UMR 8149, Clichy, France
    Gastroenterology 130:2189-97. 2006
    ..We used this approach to monitor the kinetics of serum proteome in patients with chronic hepatitis C virus infection receiving a standard bitherapy regimen to predict treatment response...
  51. doi request reprint Assessment of hepatitis C: non-invasive fibrosis markers and/or liver biopsy
    Pierre Bedossa
    Department of Pathology, Beaujon Hospital, Assistance Publique Hopitaux de Paris, INSERM, Paris Diderot University, Paris, France
    Liver Int 29:19-22. 2009
    ..In this article, the strengths and weaknesses of liver biopsy and of non-invasive markers will be reviewed and their respective roles in management of patients with chronic hepatitis C will be discussed...
  52. doi request reprint Non-invasive assessment of liver fibrosis by stiffness measurement in patients with chronic hepatitis B
    Patrick Marcellin
    Service d Hépatologie and INSERM U 773, Hopital Beaujon, AP HP, University of Paris, Clichy, France
    Liver Int 29:242-7. 2009
    ..This study aims to assess its diagnosis accuracy in patients with chronic hepatitis B...
  53. doi request reprint Acute liver cell damage in patients with anorexia nervosa: a possible role of starvation-induced hepatocyte autophagy
    Pierre Emmanuel Rautou
    Pôle des Maladies de l Appareil Digestif, Service d Hepatologie, Hopital Beaujon, AP HP, Clichy, France
    Gastroenterology 135:840-8, 848.e1-3. 2008
    ..Acute liver insufficiency is a rare complication of anorexia nervosa. The mechanisms for this complication are unclear. The aim of this study was to describe patient characteristics and clarify the mechanisms involved...
  54. pmc Frozen sectioning of the pancreatic cut surface during resection of intraductal papillary mucinous neoplasms of the pancreas is useful and reliable: a prospective evaluation
    Anne Couvelard
    Department of Pathology, Hospital Beaujon, University Paris VII, AP HP, 100 Boulevard du General Leclerc, 92118 Clichy Cedex, France
    Ann Surg 242:774-8, discussion 778-80. 2005
    ..To prospectively evaluate the accuracy of frozen sectioning (FS) of the pancreatic transection margin and its influence on surgery during resection of intraductal papillary and mucinous neoplasms (IPMNs)...
  55. doi request reprint [A rare cervical tumor]
    Emna Chelbi
    Service d Anatomie et de Cytologie Pathologiques, Hopital Beaujon, 100, boulevard Général Leclerc, 92118 Clichy, France
    Ann Pathol 28:170-2. 2008
  56. ncbi request reprint Impact of different combined preservation modalities on warm ischemic kidneys: effect on oxidative stress, hydrostatic perfusion characteristics and tissue damage
    Elodie Fabre
    Laboratoire de Chirurgie Expérimentale UPRES EA 1602, Faculte de Medecine Paris Sud, Le Kremlin Bicetre, France
    Urol Res 30:89-96. 2002
    ..The reperfusion of HPP with UWCSS emphasises the stress initiated by CS. In addition an increase in damage occurred in the CS + HPP group...
  57. doi request reprint [A case of epithelioid hemangioma of the spine]
    Julien Calderaro
    Service d Anatomie et Cytologie Pathologiques, Hopital Beaujon, 100, boulevard du General Leclerc, 92110 Clichy, France
    Ann Pathol 31:312-5. 2011
    ..Precise histological diagnosis is essential for accurate clinical management and to avoid overtreatment...
  58. ncbi request reprint Use of laser capture microdissection for clonal analysis
    Valerie Paradis
    Department of Pathology, Beaujon Hospital, 92110 Clichy, France
    Methods Enzymol 356:129-36. 2002
  59. ncbi request reprint [Neoplastic intraepithelial lesions of pancreatic ducts: new entities]
    Pierre Bedossa
    Service d Anatomie Pathologique, Hopital de Bicetre, 78, rue du General Leclerc, 94275 Le Kremlin Bicetre, France
    Ann Pathol 22:357-66. 2002
    ..PanIN classification might resume the different successive steps of molecular genetic or epigenetic events associated with the development of a pancreatic carcinoma...
  60. ncbi request reprint Solid adenoma with exclusive hepatocellular differentiation: a new variant among pancreatic benign neoplasms?
    Peggy Cuilliere
    Service d Anatomie Pathologique, CHU de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre, France
    Virchows Arch 441:519-22. 2002
    ..The main differential diagnoses include hepatoid ductal adenocarcinoma, hepatoid acinar cell carcinoma, primitive hepatoid endocrine tumor, and metastatic hepatocellular carcinoma...
  61. ncbi request reprint [Post-cholecystectomy amputation neuroma of the common bile duct with obstructive jaundice]
    Mathieu Capovilla
    Service d Anatomie Pathologique, Hopital de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre cedex, France
    Gastroenterol Clin Biol 29:79-81. 2005
    ..Despite its rarity, amputation neuroma of the common bile duct should be considered in patients with post-cholecystectomy syndrome following liver or extrahepatic bile duct surgical procedures...
  62. doi request reprint Serum alpha-fetoprotein predicts virologic response to hepatitis C treatment in HIV coinfected patients
    Fabrice Carrat
    UPMC Paris6, UMR S707, INSERM, UMR S707, Saint Antoine Hospital, Assistance Publique Hopitaux de Paris, France
    AIDS 22:1513-5. 2008
    ..83; 95% confidence interval 1.05-3.20). Serum alpha-fetoprotein measurement should be integrated in the pretreatment assessment of prognostic factors of a virologic response...
  63. ncbi request reprint Global proteomic analysis of microdissected cirrhotic nodules reveals significant biomarkers associated with clonal expansion
    Nathalie Guedj
    CNRS UMR 8149, Faculte de Pharmacie, Paris V, Paris, France
    Lab Invest 86:951-8. 2006
    ..This study confirms that proteome analysis can be achieved from a limited number of microdissected cells, and provides further insight into the process of clonal expansion and malignant transformation of cirrhotic nodules...
  64. ncbi request reprint Hepatic steatosis in HIV-HCV coinfected patients: analysis of risk factors
    Firouzé Bani-Sadr
    Groupe Hospitalier Universitaire Est, Universite Paris 6, INSERM V707, Paris, France
    AIDS 20:525-31. 2006
    ..To evaluate the prevalence and severity of steatosis and possible interactions between steatosis, host factors, viral factors, and treatment for HIV infection in HIV-hepatitis C virus (HCV) coinfected patients...
  65. ncbi request reprint Liver gene expression signature of mild fibrosis in patients with chronic hepatitis C
    Tarik Asselah
    Service d hépatologie and INSERM CRB3, AP HP Hôpital Beaujon, University of Paris VII, Paris, France
    Gastroenterology 129:2064-75. 2005
    ....
  66. ncbi request reprint Identification of a new marker of hepatocellular carcinoma by serum protein profiling of patients with chronic liver diseases
    Valerie Paradis
    Faculte de Pharmacie, CNRS UMR 8149, Paris, France
    Hepatology 41:40-7. 2005
    ..In conclusion, global protein profiling is an efficient approach that enabled us to identify a catalytic fragment ofvitronectin as a new serum marker of HCC in patients with chronic liver diseases...
  67. ncbi request reprint Molecular profiling of early stage liver fibrosis in patients with chronic hepatitis C virus infection
    Ivan Bieche
    Laboratoire de Génétique Moléculaire UPRES EA 3618, Faculte des Sciences Pharmaceutiques et Biologiques, Universite Paris V, Paris, France
    Virology 332:130-44. 2005
    ..Some of the genes identified here could form the basis for new approaches aimed at refining IFN-based therapies for chronic HCV infection...
  68. ncbi request reprint Reversibility of hepatitis C virus-related cirrhosis
    Stanislas Pol
    Unité d Hépatologie, Hopital Necker, Paris, France
    Hum Pathol 35:107-12. 2004
    ..In conclusion, long-lasting suppression of the necroinflammatory activity of liver disease and/or antifibrogenetic effects of interferon-alpha may allow regression of cirrhosis...
  69. ncbi request reprint Respective roles of porto-septal fibrosis and centrilobular fibrosis in alcoholic liver disease
    Sophie Michalak
    Laboratoire d Anatomie Pathologique, CHU, 49033 Angers Cedex 01, France
    J Pathol 201:55-62. 2003
    ..PTF is more responsible for the amount of fibrosis than CLF. The results of this study also validate the use of the Metavir fibrosis score in alcoholic chronic liver disease...
  70. pmc Molecular profiling of hepatocellular carcinomas (HCC) using a large-scale real-time RT-PCR approach: determination of a molecular diagnostic index
    Valerie Paradis
    Centre National de la Recherche Scientifique FRE 2443, Faculte de Pharmacie, Paris V, France
    Am J Pathol 163:733-41. 2003
    ..It might be useful to correctly diagnose borderline lesion or small well-differentiated hepatocellular carcinomas whose diagnosis is often difficult on a histopathological basis...
  71. ncbi request reprint A comparison of fibrosis progression in chronic liver diseases
    Thierry Poynard
    Service d Hepato Gastroenterologie, Groupe Hospitalier Pitie Salpetriere, et UPRESA 8067 CNRS, 47 83 boulevard de l Hopital, 75651 Paris Cedex 13, France
    J Hepatol 38:257-65. 2003
    ..No study has compared the liver fibrosis progression rates among chronic liver diseases and the risk factors in order to better organize screening strategies...
  72. ncbi request reprint Glypican-3 expression in hepatocellular tumors: diagnostic value for preneoplastic lesions and hepatocellular carcinomas
    Xiao Ying Wang
    Service d Anatomie Pathologique Hôpital Beaujon, Clichy, France
    Hum Pathol 37:1435-41. 2006
    ..Our results also suggest that GPC3 may be considered as an early marker of liver carcinogenesis because it is able to identify some cirrhotic macronodules with malignant potential...
  73. ncbi request reprint Direct and indirect evidence for the reversibility of cirrhosis
    Jeanne Serpaggi
    Service d Hépatologie et INSERM U 567, Hopital Necker Enfants Malades, Paris, France
    Hum Pathol 37:1519-26. 2006
    ..Using repeated liver biopsies, clinicobiochemical, radiologic, and endoscopic tests, we provide evidence for potential reversibility of cirrhosis after long-lasting suppression of the necro-inflammatory activity of liver disease...
  74. ncbi request reprint [Non invasive markers using for the assessment of fibrosis in hepatitis C]
    Jean Pierre Zarski
    Clinique universitaire d hepato gastroentérologie, pôle DIGI DUNE, Unité INSERM U 548, CHU de Grenoble, Grenoble Cedex 9
    Gastroenterol Clin Biol 31:4S34-9. 2007
    ..Diagnostic accuracy is improved by the using of all the markers, especially of Fibrotest. Transient elastography is also a promising method for assessing the severity of cirrhosis...
  75. ncbi request reprint Serum alpha-foetoprotein level predicts treatment outcome in chronic hepatitis C
    Sylvia Males
    Unité d Epidémiologie des Maladies Emergentes, Institut Pasteur, Paris, France
    Antivir Ther 12:797-803. 2007
    ..To analyse the association between serum alpha-foetoprotein (AFP) levels and sustained virological response (SVR) in treated patients...
  76. doi request reprint Progression of fibrosis in HIV and hepatitis C virus-coinfected patients treated with interferon plus ribavirin-based therapy: analysis of risk factors
    Firouzé Bani-Sadr
    Groupe Hospitalier Universitaire Est, Universite Paris 6, INSERM U707, France
    Clin Infect Dis 46:768-74. 2008
    ..We determined the prevalence and determinants of worsening fibrosis in patients coinfected with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) who were receiving anti-HCV therapy...
  77. doi request reprint How to measure the diagnostic accuracy of noninvasive liver fibrosis indices: the area under the ROC curve revisited
    Jerome Lambert
    Université Pierre et Marie Curie Paris INSERM, UMR S 707 unité de santé publique, Assistance Publique Hopitaux de Paris, Hopital Saint Antoine, Paris, France
    Clin Chem 54:1372-8. 2008
    ..We explored other fibrosis staging accuracy measures designed for ordinal gold standards, the C-statistic and the Obuchowski measure...
  78. ncbi request reprint Genetics, genomics, and proteomics: implications for the diagnosis and the treatment of chronic hepatitis C
    Tarik Asselah
    Service d Hépatologie and INSERM U773, CRB3, University of Paris VII, AP HP Hôpital Beaujon, Clichy, France
    Semin Liver Dis 27:13-27. 2007
    ..This article reviews genetic, genomic, and proteomic aspects associated with the natural history of HCV infection (i.e., viral clearance, fibrosis progression) and the response to therapy...
  79. ncbi request reprint In the new area of noninvasive markers of hepatocellular carcinoma
    Valerie Paradis
    J Hepatol 46:9-11. 2007
  80. ncbi request reprint Cryoglobulinemia is associated with steatosis and fibrosis in chronic hepatitis C
    David Saadoun
    Service de Médecine Interne and CNRS UMR 7087, Hopital Pitie Salpetriere, Paris, France
    Hepatology 43:1337-45. 2006
    ..001), and steatosis higher than 10% (P = .04). In conclusion, our study shows an independent association between cryoglobulin and steatosis as well as advanced fibrosis...
  81. pmc Liver fibrosis in women with chronic hepatitis C: evidence for the negative role of the menopause and steatosis and the potential benefit of hormone replacement therapy
    Liana Codes
    Service d Hepatologie, University of Paris VII, AP HP Hôpital Beaujon, Clichy, France
    Gut 56:390-5. 2007
    ..The aim of this study was to evaluate the severity of chronic hepatitis C in women, in relation to the menopause, steatosis and hormone replacement therapy (HRT)...
  82. ncbi request reprint Changes in renal function in patients with familial amyloid polyneuropathy treated with orthotopic liver transplantation
    Renaud Snanoudj
    Service de Nephrologie, Hémodialyse et Transplantation, Villejuif, France
    Nephrol Dial Transplant 19:1779-85. 2004
    ..Orthotopic liver transplantation (OLT) has been proposed to prevent disease progression. Little is known about long-term changes in renal function and lesions after OLT...
  83. ncbi request reprint Signet-ring cell change in acute erosive gastropathy
    Stephanie Dimet
    Am J Surg Pathol 28:1111-2. 2004
  84. ncbi request reprint Sources of variability in histological scoring of chronic viral hepatitis
    Marie Christine Rousselet
    Laboratoire d Anatomie Pathologique, Angers, France
    Hepatology 41:257-64. 2005
    ..Agreement can be improved by experienced pathologist or consensus reading...
  85. ncbi request reprint p63 gene expression study and early bladder carcinogenesis
    Eva Comperat
    CNRS UMR 8149, Faculté de Pharmacie Paris V, Paris, France
    Urology 70:459-62. 2007
    ....
  86. ncbi request reprint A clear cell malignant gastrinoma of the pancreas with cytoplasmic accumulation of lipid droplets
    Adjé Abbey-Toby
    Virchows Arch 448:105-6. 2006
  87. ncbi request reprint Risk factors of fibrosis in alcohol-induced liver disease
    Bruno Raynard
    Service d Hepato Gastroenterologie, Hopital Antoine Beclere, 157 rue de la Porte de Trivaux, 92141 Clamart Cedex, France
    Hepatology 35:635-8. 2002
    ....
  88. ncbi request reprint Increased infiltration of macrophages in omental adipose tissue is associated with marked hepatic lesions in morbid human obesity
    Raffaella Cancello
    INSERM, U755 Nutriomique, Service de Nutrition, Hotel Dieu, 1 Place du Parvis Notre Dame, 75004 Paris, France
    Diabetes 55:1554-61. 2006
    ..These data suggest that the presence of macrophages in omental WAT participates in the cellular mechanisms favoring hepatic fibroinflammatory lesions in obese patients...
  89. ncbi request reprint Genetic analysis of autoimmune sialadenitis in nonobese diabetic mice: a major susceptibility region on chromosome 1
    Olivier Boulard
    Institut National de la Sante et de la Recherche Medicale, Unité 25, Hopital Necker Enfants Malades, Paris, France
    J Immunol 168:4192-201. 2002
    ..1 in females and on chr.7 in males, probably because of the latent autoimmune predisposition of the NZW strain. Altogether these findings reflect the complexity and heterogeneity of human SS...