Pierre Bedossa

Summary

Country: France

Publications

  1. ncbi Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity
    Corneliu Henegar
    INSERM, UMR S 872, Les Cordeliers, Eq, 7 Nutriomique and Eq, 13, Paris, F 75006 France
    Genome Biol 9:R14. 2008
  2. ncbi Images in hepatology. Telangiectatic adenoma: a variant of hepatocellular adenoma
    Pierre Bedossa
    , Service d' Anatomie Pathologique
    Ann Hepatol 3:163. 2004
  3. ncbi Sampling variability of liver fibrosis in chronic hepatitis C
    Pierre Bedossa
    Service d Anatomie Pathologique, Hopital Bicetre, Le Kremlin Bicetre, France
    Hepatology 38:1449-57. 2003
  4. ncbi Liver extracellular matrix in health and disease
    Pierre Bedossa
    Service d Anatomie Pathologique, CNRS FRE2443, Hopital de Bicetre, 78 Avenue Géneral Leclerc, 94275 Le Kremlin Bicetre, France
    J Pathol 200:504-15. 2003
  5. ncbi [Regression of hepatic fibrosis physiopathological aspects and clinical reality]
    Pierre Bedossa
    Service d Anatomie Pathologique, CNRS ESA 8067, Hôpital Bicêtre Le Kremlin Bicêtre 94
    Presse Med 32:704-10. 2003
  6. ncbi Approaches for treatment of liver fibrosis in chronic hepatitis C
    Pierre Bedossa
    Department of Pathology, Service d Anatomie Pathologique, Hopital Bicetre, Universite Paris XI, 78 rue du General Leclerc, 94725 Le Kremlin Bicêtre, France
    Clin Liver Dis 7:195-210. 2003
  7. ncbi Dystroglycan expression in hepatic stellate cells: role in liver fibrosis
    Pierre Bedossa
    Service d Anatomie Pathologique, Hopital de Bicetre, Universite Paris Sud, France
    Lab Invest 82:1053-61. 2002
  8. ncbi Heterogeneity of tumor prognostic markers: a reproducibility study applied to liver metastases of pancreatic endocrine tumors
    Anne Couvelard
    Department of Pathology, University of Paris 7, Assistance Publique Hopitaux de Paris, Beaujon Hospital, Clichy, France
    Mod Pathol 22:273-81. 2009
  9. ncbi Overexpression of the oxygen sensors PHD-1, PHD-2, PHD-3, and FIH Is associated with tumor aggressiveness in pancreatic endocrine tumors
    Anne Couvelard
    Department of Pathology, University Paris 7, Clichy, France
    Clin Cancer Res 14:6634-9. 2008
  10. ncbi Telangiectatic focal nodular hyperplasia: a variant of hepatocellular adenoma
    Valerie Paradis
    Service d Anatomie Pathologique, Hopital Beaujon, Clichy, France
    Gastroenterology 126:1323-9. 2004

Detail Information

Publications73

  1. ncbi Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity
    Corneliu Henegar
    INSERM, UMR S 872, Les Cordeliers, Eq, 7 Nutriomique and Eq, 13, Paris, F 75006 France
    Genome Biol 9:R14. 2008
    ..However, the overall importance of these alterations, and their long-term impact on the metabolic functions of the WAT and on its morphology, remain unclear...
  2. ncbi Images in hepatology. Telangiectatic adenoma: a variant of hepatocellular adenoma
    Pierre Bedossa
    , Service d' Anatomie Pathologique
    Ann Hepatol 3:163. 2004
  3. ncbi Sampling variability of liver fibrosis in chronic hepatitis C
    Pierre Bedossa
    Service d Anatomie Pathologique, Hopital Bicetre, Le Kremlin Bicetre, France
    Hepatology 38:1449-57. 2003
    ..Sampling variability becomes a major limitation when using more accurate methods such as automated image analysis...
  4. ncbi Liver extracellular matrix in health and disease
    Pierre Bedossa
    Service d Anatomie Pathologique, CNRS FRE2443, Hopital de Bicetre, 78 Avenue Géneral Leclerc, 94275 Le Kremlin Bicetre, France
    J Pathol 200:504-15. 2003
    ..In addition to these experimental data, experience from chronic hepatitis C now allows the development of new concepts and perspectives such as liver fibrosis regression and antifibrotic therapies...
  5. ncbi [Regression of hepatic fibrosis physiopathological aspects and clinical reality]
    Pierre Bedossa
    Service d Anatomie Pathologique, CNRS ESA 8067, Hôpital Bicêtre Le Kremlin Bicêtre 94
    Presse Med 32:704-10. 2003
    ..Although these treatments have shown efficacy on experimental models of fibrosis, to date, there are no published results formally confirming the efficacy and safety of these treatments in man...
  6. ncbi Approaches for treatment of liver fibrosis in chronic hepatitis C
    Pierre Bedossa
    Department of Pathology, Service d Anatomie Pathologique, Hopital Bicetre, Universite Paris XI, 78 rue du General Leclerc, 94725 Le Kremlin Bicêtre, France
    Clin Liver Dis 7:195-210. 2003
    ..It is likely that in the future, besides viral eradication, another treatment goal in chronic HCV infection will be to reverse existing fibrosis, but considerable work is necessary before making this a reality...
  7. ncbi Dystroglycan expression in hepatic stellate cells: role in liver fibrosis
    Pierre Bedossa
    Service d Anatomie Pathologique, Hopital de Bicetre, Universite Paris Sud, France
    Lab Invest 82:1053-61. 2002
    ..Dystroglycan interaction with laminin should be implicated in the concentration of pericellular laminin and in the constitution of a perisinusoidal basement membrane during liver fibrosis...
  8. ncbi Heterogeneity of tumor prognostic markers: a reproducibility study applied to liver metastases of pancreatic endocrine tumors
    Anne Couvelard
    Department of Pathology, University of Paris 7, Assistance Publique Hopitaux de Paris, Beaujon Hospital, Clichy, France
    Mod Pathol 22:273-81. 2009
    ..Sampling variability should be taken into consideration as a potential limitation to the assessment of prognostic and therapeutic markers in biopsy samples from metastatic pancreatic endocrine tumors...
  9. ncbi Overexpression of the oxygen sensors PHD-1, PHD-2, PHD-3, and FIH Is associated with tumor aggressiveness in pancreatic endocrine tumors
    Anne Couvelard
    Department of Pathology, University Paris 7, Clichy, France
    Clin Cancer Res 14:6634-9. 2008
    ..e., prolyl hydroxylase domain proteins (PHD)-1, PHD-2, PHD-3, and FIH in pancreatic endocrine tumors (PET)...
  10. ncbi Telangiectatic focal nodular hyperplasia: a variant of hepatocellular adenoma
    Valerie Paradis
    Service d Anatomie Pathologique, Hopital Beaujon, Clichy, France
    Gastroenterology 126:1323-9. 2004
    ..Therefore, the aim of the present study was to reconsider the classification of telangiectatic FNH with the help of a molecular approach...
  11. ncbi Hepatocellular carcinomas in patients with metabolic syndrome often develop without significant liver fibrosis: a pathological analysis
    Valerie Paradis
    Service d Anatomie Pathologique, Hopital Beaujon, Clichy, France
    Hepatology 49:851-9. 2009
    ..In addition, some of them arise through malignant transformation of a preexisting liver cell adenoma...
  12. ncbi SCG10 expression on activation of hepatic stellate cells promotes cell motility through interference with microtubules
    Valerie Paradis
    Department of Pathology, INSERM U773, the Serviced Hépatologie, Beaujon Hospital, AP HP, University Paris Diderot, Paris, France
    Am J Pathol 177:1791-7. 2010
    ..SCG10 may represent a potential molecular target for anti-fibrosis therapies...
  13. ncbi Molecular profiling of pancreatic neuroendocrine tumors in sporadic and Von Hippel-Lindau patients
    Daniela Speisky
    Service d Anatomie Pathologique, Service de Gastroentérologie Pancréatologie, Service de Chirurgie Hépatique et Pancréatique, AP HP, Hopital Beaujon, Clichy, France
    Clin Cancer Res 18:2838-49. 2012
    ..Our aim was to characterize by molecular quantitative analysis a panel of molecules implicated in the VHL pathway and in tumor progression in the PanNET of patients with VHL...
  14. ncbi The expression of the hypoxia markers CA9 and CXCR4 is correlated with survival in patients with neuroendocrine tumours of the ileum
    Lydia Deschamps
    Service d Anatomie Pathologique, CRB3 INSERM U773, Hopital Beaujon, Clichy, France
    Neuroendocrinology 95:214-22. 2012
    ..Our aim was to investigate the expression of these markers in a series of patients with an ileal neuroendocrine tumour (IET) at various stages of tumorigenesis...
  15. ncbi Biological and prognostic relevance of mitogen-activated protein kinases in pancreatic adenocarcinoma
    Adriana Handra-Luca
    Service d Anatomie Pathologique, APHP Groupe Hospitalier Universitaire Nord, Bobigny, France
    Pancreas 41:416-21. 2012
    ....
  16. ncbi Quantitative RT-PCR in cirrhotic nodules reveals gene expression changes associated with liver carcinogenesis
    Magali Colombat
    Service d Anatomie Pathologique, Hopital Beaujon, Clichy, France
    J Pathol 201:260-7. 2003
    ..The decrease in the expression level of one of these genes, LYVE1, was associated with monoclonality in cirrhotic nodules...
  17. ncbi Telangiectatic adenoma: an entity associated with increased body mass index and inflammation
    Valerie Paradis
    Service d Anatomie Pathologique, Hopital Beaujon, Clichy, France
    Hepatology 46:140-6. 2007
    ..CONCLUSION: This study has shown that TAs occur in a characteristic background of overweight patients and are often associated with a biological inflammatory syndrome. Moreover, a TA may progress to malignancy...
  18. ncbi Evidence for a role of nonalcoholic steatohepatitis in hepatitis C: a prospective study
    Pierre Bedossa
    Service d Anatomie Pathologique, CNRS UMR 8149, Clichy, France
    Hepatology 46:380-7. 2007
    ..NASH is more common in genotype 3 and is not associated with metabolic dysfunctions in this subgroup, suggesting that NASH may complicate steatosis in CHC irrespective of etiology of steatosis...
  19. ncbi [Pancreatic perivascular epithelioid cell tumor (PEComa)]
    Martine Perigny
    Service d Anatomie Pathologique, Hopital Beaujon, AP HP, Universite Paris 7 Denis Diderot, 100, boulevard du General Leclerc, 92110 Clichy, France
    Ann Pathol 28:138-42. 2008
    ..These features were consistent with a PEComa. Pancreatic PEComas are rare, but should be included in the differential diagnostic of pancreatic clear cells tumors or pancreatic spindle- and epithelioid-cells tumors...
  20. ncbi Effects and regulation of connective tissue growth factor on hepatic stellate cells
    Valerie Paradis
    Service d Anatomie Pathologique, Hopital de Bicetre, Le Kremlin Bicetre, France
    Lab Invest 82:767-74. 2002
    ..In conclusion, this study extends the role of CTGF in HSC activation and suggests that CTGF up-regulation might be a central pathway during HSC activation...
  21. ncbi Identification of potential therapeutic targets by gene-expression profiling in pancreatic endocrine tumors
    Anne Couvelard
    Department of Pathology, Beaujon Hospital, Assistance Publique Hopitaux de Paris AP HP, Clichy, France
    Gastroenterology 131:1597-610. 2006
    ..The aim of this study was to characterize PET gene expression by complementary DNA (cDNA) microarray and identify specific differences in gene-expression profiles between nonmetastatic and metastatic tumors...
  22. ncbi CD10 expression in pancreatic endocrine tumors: correlation with prognostic factors and survival
    Lydia Deschamps
    Department of Pathology, AP-HP, Beaujon Hospital, 92110 Clichy, France
    Hum Pathol 37:802-8. 2006
    ..In conclusion, CD10 is expressed in a subset of PETs and correlates with histopathologic indicators of poor outcome, suggesting a role for this molecule in tumorigenesis and prognostic analysis...
  23. ncbi Predictors of tumor response after preoperative chemoradiotherapy for rectal adenocarcinomas
    Nathalie Guedj
    Department of Pathology, Beaujon Hospital, 92110 Clichy, France
    Hum Pathol 42:1702-9. 2011
    ..This study highlighted the importance of predictive criteria to chemoradiotherapy response in proposing to selected patients an alternative treatment (eg, local resection) to more radical surgery...
  24. ncbi [Sclerosing mesenteritis: can it be a IgG4 dysimmune disease?]
    Hicham Belghiti
    Service d Anatomie Pathologique, Hopital Beaujon, AP HP, 92118 Clichy Cedex, France
    Ann Pathol 29:468-74. 2009
    ..The pathogenesis is unknown until now. Hypothesis of a dysimmune disorder is advocated. Our purpose was to find histological basis to assert this hypothesis...
  25. ncbi The role of replicative senescence in chronic allograft nephropathy
    Sophie Ferlicot
    Department of Pathology, , , , France
    Hum Pathol 34:924-8. 2003
    ..These results suggest that replicative senescence is a mechanism that might be involved in the development of CAN. The age of the donor appears to be the major determinant factor in replicative senescence...
  26. ncbi Assessment of hepatitis C: non-invasive fibrosis markers and/or liver biopsy
    Pierre Bedossa
    Department of Pathology, Beaujon Hospital, Assistance Publique Hopitaux de Paris, INSERM, Paris Diderot University, Paris, France
    Liver Int 29:19-22. 2009
    ..In this article, the strengths and weaknesses of liver biopsy and of non-invasive markers will be reviewed and their respective roles in management of patients with chronic hepatitis C will be discussed...
  27. ncbi Comparative protein expression profiles of hilar and peripheral hepatic cholangiocarcinomas
    Nathalie Guedj
    Department of Pathology, Beaujon Hospital, 100 Boulevard du General Leclerc, 92118 Clichy, France
    J Hepatol 51:93-101. 2009
    ..Hepatic cholangiocarcinomas are tumors with poor prognosis and with increasing incidence worldwide. The aim of the study was to compare morphological features and protein profiles of hilar and peripheral cholangiocarcinomas...
  28. ncbi Frozen sectioning of the pancreatic cut surface during resection of intraductal papillary mucinous neoplasms of the pancreas is useful and reliable: a prospective evaluation
    Anne Couvelard
    Department of Pathology, Hospital Beaujon, University Paris VII, AP-HP, , 92118 Clichy-Cedex, France
    Ann Surg 242:774-8, discussion 778-80. 2005
    ..According to our protocol, FS changes the extent of resection in 30% of patients and allows adequate resection in 97% of patients...
  29. ncbi Obliterative portal venopathy: portal hypertension is not always present at diagnosis
    Dominique Cazals-Hatem
    Service d Anatomie Pathologique, Hôpital Beaujon AP HP, Clichy and Institut National de la Santé et de la Recherche Médicale U773, Centre de Recherche Biomedicale Bichat Beaujon CRB3, Universite Denis Diderot Paris 7, France
    J Hepatol 54:455-61. 2011
    ..Previous studies on obliterative portal venopathy (OPV) have been biased due to the selection of patients with non-cirrhotic portal hypertension. The aim of this study was to clarify the characteristics of OVP diagnosed by liver biopsy...
  30. ncbi Impact of different combined preservation modalities on warm ischemic kidneys: effect on oxidative stress, hydrostatic perfusion characteristics and tissue damage
    Elodie Fabre
    Laboratoire de Chirurgie Expérimentale UPRES EA 1602, Faculte de Medecine Paris Sud, Le Kremlin Bicetre, France
    Urol Res 30:89-96. 2002
    ..The reperfusion of HPP with UWCSS emphasises the stress initiated by CS. In addition an increase in damage occurred in the CS + HPP group...
  31. ncbi Efficacy of peginterferon alpha-2b in chronic hepatitis delta: relevance of quantitative RT-PCR for follow-up
    Corinne Castelnau
    , , AP-HP; INSERM U773 CRB3, Clichy, , Bobigny, France
    Hepatology 44:728-35. 2006
    ..The follow-up of HDV-RNA levels during therapy, which allows the differentiation of various profiles of virological responses, improves treatment monitoring...
  32. ncbi [A rare cervical tumor]
    Emna Chelbi
    Service d'Anatomie et de Cytologie Pathologiques, , 100, , 92118 Clichy, France
    Ann Pathol 28:170-2. 2008
  33. ncbi [Post-cholecystectomy amputation neuroma of the common bile duct with obstructive jaundice]
    Mathieu Capovilla
    Service d Anatomie Pathologique, Hopital de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre cedex, France
    Gastroenterol Clin Biol 29:79-81. 2005
    ..Despite its rarity, amputation neuroma of the common bile duct should be considered in patients with post-cholecystectomy syndrome following liver or extrahepatic bile duct surgical procedures...
  34. ncbi Use of laser capture microdissection for clonal analysis
    Valerie Paradis
    Department of Pathology, Beaujon Hospital, 92110 Clichy, France
    Methods Enzymol 356:129-36. 2002
  35. ncbi Solid adenoma with exclusive hepatocellular differentiation: a new variant among pancreatic benign neoplasms?
    Peggy Cuilliere
    Service d Anatomie Pathologique, CHU de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre, France
    Virchows Arch 441:519-22. 2002
    ..The main differential diagnoses include hepatoid ductal adenocarcinoma, hepatoid acinar cell carcinoma, primitive hepatoid endocrine tumor, and metastatic hepatocellular carcinoma...
  36. ncbi [Neoplastic intraepithelial lesions of pancreatic ducts: new entities]
    Pierre Bedossa
    Service d Anatomie Pathologique, Hopital de Bicetre, 78, rue du General Leclerc, 94275 Le Kremlin Bicetre, France
    Ann Pathol 22:357-66. 2002
    ..PanIN classification might resume the different successive steps of molecular genetic or epigenetic events associated with the development of a pancreatic carcinoma...
  37. ncbi Progression of fibrosis in HIV and hepatitis C virus-coinfected patients treated with interferon plus ribavirin-based therapy: analysis of risk factors
    Firouzé Bani-Sadr
    Groupe Hospitalier Universitaire Est, Universite Paris 6, INSERM U707, France
    Clin Infect Dis 46:768-74. 2008
    ..We determined the prevalence and determinants of worsening fibrosis in patients coinfected with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) who were receiving anti-HCV therapy...
  38. ncbi Molecular profiling of hepatocellular carcinomas (HCC) using a large-scale real-time RT-PCR approach: determination of a molecular diagnostic index
    Valerie Paradis
    Centre National de la Recherche Scientifique FRE 2443, Faculte de Pharmacie, Paris V, France
    Am J Pathol 163:733-41. 2003
    ..It might be useful to correctly diagnose borderline lesion or small well-differentiated hepatocellular carcinomas whose diagnosis is often difficult on a histopathological basis...
  39. ncbi Insulin resistance in chronic hepatitis C: association with genotypes 1 and 4, serum HCV RNA level, and liver fibrosis
    Rami Moucari
    AP HP, Hopital Beaujon, Service d Hepatologie, Clichy F 92110, France
    Gastroenterology 134:416-23. 2008
    ..Our study was designed to test the association between insulin resistance (IR) and hepatitis C virus (HCV) genotypes, serum HCV RNA level and liver fibrosis stage in a large prospective cohort of chronic hepatitis C (CHC) patients...
  40. ncbi [Non invasive markers using for the assessment of fibrosis in hepatitis C]
    Jean Pierre Zarski
    Clinique universitaire d hepato gastroentérologie, pôle DIGI DUNE, Unité INSERM U 548, CHU de Grenoble, Grenoble Cedex 9
    Gastroenterol Clin Biol 31:4S34-9. 2007
    ..Diagnostic accuracy is improved by the using of all the markers, especially of Fibrotest. Transient elastography is also a promising method for assessing the severity of cirrhosis...
  41. ncbi Algorithm for immediate cytologic diagnosis of hepatic tumors
    Lawrence F Pupulim
    Service de Radiologie, Hopital Beaujon, Assistance Publique des Hopitaux de Paris, Universite Paris, 100, Blvd du Général Leclerc, 92110 Clichy, France
    AJR Am J Roentgenol 190:W208-12. 2008
    ..The purpose of this study was to analyze the diagnostic accuracy of on-site cytologic assessment compared with definitive cytologic examination in the detection and correct subtyping of malignant hepatic lesions...
  42. ncbi Eradication of hepatitis C virus in patients successfully treated for chronic hepatitis C
    Sarah Maylin
    Universite Paris VII, Hopital Beaujon, Clichy, France
    Gastroenterology 135:821-9. 2008
    ..It is unclear whether hepatitis C virus (HCV) is eradicated in patients with chronic hepatitis C who achieved a sustained virologic response (SVR)...
  43. ncbi Serum alpha-fetoprotein predicts virologic response to hepatitis C treatment in HIV coinfected patients
    Fabrice Carrat
    UPMC Paris6, UMR S707, INSERM, UMR S707, Saint Antoine Hospital, Assistance Publique Hopitaux de Paris, France
    AIDS 22:1513-5. 2008
    ..83; 95% confidence interval 1.05-3.20). Serum alpha-fetoprotein measurement should be integrated in the pretreatment assessment of prognostic factors of a virologic response...
  44. ncbi How to measure the diagnostic accuracy of noninvasive liver fibrosis indices: the area under the ROC curve revisited
    Jerome Lambert
    Université Pierre et Marie Curie Paris INSERM, UMR S 707 unité de santé publique, Assistance Publique Hopitaux de Paris, Hopital Saint Antoine, Paris, France
    Clin Chem 54:1372-8. 2008
    ..We explored other fibrosis staging accuracy measures designed for ordinal gold standards, the C-statistic and the Obuchowski measure...
  45. ncbi A comparison of fibrosis progression in chronic liver diseases
    Thierry Poynard
    Service d Hepato Gastroenterologie, Groupe Hospitalier Pitie Salpetriere, et UPRESA 8067 CNRS, 47 83 boulevard de l Hopital, 75651 Paris Cedex 13, France
    J Hepatol 38:257-65. 2003
    ..No study has compared the liver fibrosis progression rates among chronic liver diseases and the risk factors in order to better organize screening strategies...
  46. ncbi [Fibrosis in chronic hepatitis C infection: mechanisms and cofactors]
    Pierre Bedossa
    Service d'Anatomie Pathologique, CNRS ESA8067, ,
    Gastroenterol Clin Biol 26:B163-7. 2002
  47. ncbi A quantitative gene expression study suggests a role for angiopoietins in focal nodular hyperplasia
    Valerie Paradis
    Service d Anatomie Pathologique and Service de Chirurgie, Hopital Beaujon, Clichy, France
    Gastroenterology 124:651-9. 2003
    ..To gain insight into the pathogenesis of FNH, we performed a large-scale quantitative study of gene expression in FNH...
  48. ncbi Serum alpha-foetoprotein level predicts treatment outcome in chronic hepatitis C
    Sylvia Males
    Unité d Epidémiologie des Maladies Emergentes, Institut Pasteur, Paris, France
    Antivir Ther 12:797-803. 2007
    ..To analyse the association between serum alpha-foetoprotein (AFP) levels and sustained virological response (SVR) in treated patients...
  49. ncbi Serum proteome to predict virologic response in patients with hepatitis C treated by pegylated interferon plus ribavirin
    Valerie Paradis
    Service d anatomie pathologie, Hopital Beaujon, and CNRS UMR 8149, Clichy, France
    Gastroenterology 130:2189-97. 2006
    ..We used this approach to monitor the kinetics of serum proteome in patients with chronic hepatitis C virus infection receiving a standard bitherapy regimen to predict treatment response...
  50. ncbi Liver gene expression signature of mild fibrosis in patients with chronic hepatitis C
    Tarik Asselah
    Service d hépatologie and INSERM CRB3, AP HP Hôpital Beaujon, University of Paris VII, Paris, France
    Gastroenterology 129:2064-75. 2005
    ....
  51. ncbi Hepatic steatosis in HIV-HCV coinfected patients: analysis of risk factors
    Firouzé Bani-Sadr
    Groupe Hospitalier Universitaire Est, Universite Paris 6, INSERM V707, Paris, France
    AIDS 20:525-31. 2006
    ..To evaluate the prevalence and severity of steatosis and possible interactions between steatosis, host factors, viral factors, and treatment for HIV infection in HIV-hepatitis C virus (HCV) coinfected patients...
  52. ncbi Cryoglobulinemia is associated with steatosis and fibrosis in chronic hepatitis C
    David Saadoun
    , , Paris, France
    Hepatology 43:1337-45. 2006
    ..001), and steatosis higher than 10% (P = .04). In conclusion, our study shows an independent association between cryoglobulin and steatosis as well as advanced fibrosis...
  53. ncbi Reversibility of hepatitis C virus-related cirrhosis
    Stanislas Pol
    , , Paris, France
    Hum Pathol 35:107-12. 2004
    ..In conclusion, long-lasting suppression of the necroinflammatory activity of liver disease and/or antifibrogenetic effects of interferon-alpha may allow regression of cirrhosis...
  54. ncbi Molecular profiling of early stage liver fibrosis in patients with chronic hepatitis C virus infection
    Ivan Bieche
    Laboratoire de Génétique Moléculaire UPRES EA 3618, Faculte des Sciences Pharmaceutiques et Biologiques, Universite Paris V, Paris, France
    Virology 332:130-44. 2005
    ..Some of the genes identified here could form the basis for new approaches aimed at refining IFN-based therapies for chronic HCV infection...
  55. ncbi Global proteomic analysis of microdissected cirrhotic nodules reveals significant biomarkers associated with clonal expansion
    Nathalie Guedj
    CNRS UMR 8149, , Paris V, Paris, France
    Lab Invest 86:951-8. 2006
    ..This study confirms that proteome analysis can be achieved from a limited number of microdissected cells, and provides further insight into the process of clonal expansion and malignant transformation of cirrhotic nodules...
  56. ncbi Significant gene expression differences in histologically "Normal" liver biopsies: Implications for control tissue
    Tarik Asselah
    Service d Hépatologie and Institut National de la Santé et de la Recherche Médicale INSERM U733, CRB3, Universite Paris Diderot, Assistance Publique Hopitaux de Paris, Hopital Beaujon, Clichy, France
    Hepatology 48:953-62. 2008
    ....
  57. ncbi Glypican-3 expression in hepatocellular tumors: diagnostic value for preneoplastic lesions and hepatocellular carcinomas
    Xiao Ying Wang
    , Clichy, France
    Hum Pathol 37:1435-41. 2006
    ..Our results also suggest that GPC3 may be considered as an early marker of liver carcinogenesis because it is able to identify some cirrhotic macronodules with malignant potential...
  58. ncbi Direct and indirect evidence for the reversibility of cirrhosis
    Jeanne Serpaggi
    , , Paris, France
    Hum Pathol 37:1519-26. 2006
    ..Using repeated liver biopsies, clinicobiochemical, radiologic, and endoscopic tests, we provide evidence for potential reversibility of cirrhosis after long-lasting suppression of the necro-inflammatory activity of liver disease...
  59. ncbi Liver fibrosis in women with chronic hepatitis C: evidence for the negative role of the menopause and steatosis and the potential benefit of hormone replacement therapy
    Liana Codes
    Service d Hepatologie, University of Paris VII, AP HP Hôpital Beaujon, Clichy, France
    Gut 56:390-5. 2007
    ..The aim of this study was to evaluate the severity of chronic hepatitis C in women, in relation to the menopause, steatosis and hormone replacement therapy (HRT)...
  60. ncbi Respective roles of porto-septal fibrosis and centrilobular fibrosis in alcoholic liver disease
    Sophie Michalak
    Laboratoire d'Anatomie-Pathologique, CHU, 49033 Angers Cedex 01, France
    J Pathol 201:55-62. 2003
    ..PTF is more responsible for the amount of fibrosis than CLF. The results of this study also validate the use of the Metavir fibrosis score in alcoholic chronic liver disease...
  61. ncbi In the new area of noninvasive markers of hepatocellular carcinoma
    Valerie Paradis
    J Hepatol 46:9-11. 2007
  62. ncbi Genetics, genomics, and proteomics: implications for the diagnosis and the treatment of chronic hepatitis C
    Tarik Asselah
    Service d Hépatologie and INSERM U773, CRB3, University of Paris VII, AP HP Hôpital Beaujon, Clichy, France
    Semin Liver Dis 27:13-27. 2007
    ..This article reviews genetic, genomic, and proteomic aspects associated with the natural history of HCV infection (i.e., viral clearance, fibrosis progression) and the response to therapy...
  63. ncbi Identification of a new marker of hepatocellular carcinoma by serum protein profiling of patients with chronic liver diseases
    Valerie Paradis
    Faculte de Pharmacie, CNRS UMR 8149, Paris, France
    Hepatology 41:40-7. 2005
    ..In conclusion, global protein profiling is an efficient approach that enabled us to identify a catalytic fragment ofvitronectin as a new serum marker of HCC in patients with chronic liver diseases...
  64. ncbi Changes in renal function in patients with familial amyloid polyneuropathy treated with orthotopic liver transplantation
    Renaud Snanoudj
    , , Villejuif, France
    Nephrol Dial Transplant 19:1779-85. 2004
    ..CONCLUSION: Although liver transplantation in FAP does not affect existing renal amyloid deposits, it prevents the progression of renal disease...
  65. ncbi Sources of variability in histological scoring of chronic viral hepatitis
    Marie-Christine Rousselet
    Laboratoire d'Anatomie-Pathologique, Angers, France
    Hepatology 41:257-64. 2005
    ..Agreement can be improved by experienced pathologist or consensus reading...
  66. ncbi Genetic analysis of autoimmune sialadenitis in nonobese diabetic mice: a major susceptibility region on chromosome 1
    Olivier Boulard
    Institut National de la Sante et de la Recherche Medicale, Unité 25, Hopital Necker Enfants Malades, Paris, France
    J Immunol 168:4192-201. 2002
    ..1 in females and on chr.7 in males, probably because of the latent autoimmune predisposition of the NZW strain. Altogether these findings reflect the complexity and heterogeneity of human SS...
  67. ncbi A clear cell malignant gastrinoma of the pancreas with cytoplasmic accumulation of lipid droplets
    Adjé Abbey-Toby
    Virchows Arch 448:105-6. 2006
  68. ncbi Increased infiltration of macrophages in omental adipose tissue is associated with marked hepatic lesions in morbid human obesity
    Raffaella Cancello
    INSERM, U755 Nutriomique, Service de Nutrition, , 1 place du Parvis Notre-Dame, 75004 Paris, France
    Diabetes 55:1554-61. 2006
    ..These data suggest that the presence of macrophages in omental WAT participates in the cellular mechanisms favoring hepatic fibroinflammatory lesions in obese patients...
  69. ncbi Signet-ring cell change in acute erosive gastropathy
    Stephanie Dimet
    Am J Surg Pathol 28:1111-2. 2004
  70. ncbi Risk factors of fibrosis in alcohol-induced liver disease
    Bruno Raynard
    , , 157 rue de la Porte de Trivaux, 92141 Clamart Cedex, France
    Hepatology 35:635-8. 2002
    ....
  71. ncbi Acute liver cell damage in patients with anorexia nervosa: a possible role of starvation-induced hepatocyte autophagy
    Pierre Emmanuel Rautou
    Pôle des Maladies de l Appareil Digestif, Service d Hepatologie, Hopital Beaujon, AP HP, Clichy, France
    Gastroenterology 135:840-8, 848.e1-3. 2008
    ..Acute liver insufficiency is a rare complication of anorexia nervosa. The mechanisms for this complication are unclear. The aim of this study was to describe patient characteristics and clarify the mechanisms involved...
  72. ncbi p63 gene expression study and early bladder carcinogenesis
    Eva Comperat
    CNRS UMR 8149, Faculté de Pharmacie Paris V, Paris, France
    Urology 70:459-62. 2007
    ....
  73. ncbi Measurement of telomere length on tissue sections using quantitative fluorescence in situ hybridization (Q-FISH)
    Sophie Ferlicot
    Services d'Anatomie Pathologique, , , , France
    J Pathol 200:661-6. 2003
    ..It is an easy, accurate, and reproducible in situ method for assessing telomeres in the context of cell type and tissue architecture...