Laurent Beck

Summary

Country: France

Publications

  1. pmc Mice with hypomorphic expression of the sodium-phosphate cotransporter PiT1/Slc20a1 have an unexpected normal bone mineralization
    Annabelle Bourgine
    Institut National de la Sante et de la Recherche Medicale, U791, LIOAD, STEP group Skeletal Tissue Engineering and Physiopathology, Nantes, France
    PLoS ONE 8:e65979. 2013
  2. pmc The phosphate transporter PiT1 (Slc20a1) revealed as a new essential gene for mouse liver development
    Laurent Beck
    INSERM, U845, Centre de Recherche Croissance et Signalisation, Paris, France
    PLoS ONE 5:e9148. 2010
  3. pmc Identification of a novel function of PiT1 critical for cell proliferation and independent of its phosphate transport activity
    Laurent Beck
    Growth and Signalling Research Center, INSERM, U845, F 75015 Paris
    J Biol Chem 284:31363-74. 2009
  4. pmc A new human NHERF1 mutation decreases renal phosphate transporter NPT2a expression by a PTH-independent mechanism
    Marie Courbebaisse
    Faculte de Medecine, Universite Paris Descartes, Paris, France
    PLoS ONE 7:e34764. 2012
  5. doi request reprint EKLF-driven PIT1 expression is critical for mouse erythroid maturation in vivo and in vitro
    Anne Forand
    INSERM U845, Paris, France
    Blood 121:666-78. 2013
  6. doi request reprint The emergence of phosphate as a specific signaling molecule in bone and other cell types in mammals
    Solmaz Khoshniat
    Centre for Osteoarticular and Dental Tissue Engineering, INSERM, U, Nantes, France
    Cell Mol Life Sci 68:205-18. 2011
  7. doi request reprint NHERF1 mutations and responsiveness of renal parathyroid hormone
    Zoubida Karim
    INSERM Unité 845, Universite Paris Descartes, Faculte de Medecine, Paris, France
    N Engl J Med 359:1128-35. 2008
  8. pmc Identification of a novel transport-independent function of PiT1/SLC20A1 in the regulation of TNF-induced apoptosis
    Christine Salaun
    Growth and Signaling Research Center, INSERM U845, F 75015 Paris, France
    J Biol Chem 285:34408-18. 2010
  9. ncbi request reprint Recent findings in phosphate homeostasis
    Dominique Prie
    Inserm U 426 et Institut Fédératif de Recherche 02, Faculty of Medicine, Xavier Bichat, Paris, France
    Curr Opin Nephrol Hypertens 14:318-24. 2005
  10. doi request reprint Phosphate-dependent regulation of MGP in osteoblasts: role of ERK1/2 and Fra-1
    Marion Julien
    INSERM, U 791, Laboratoire d Ingénierie des Tissus Ostéo Articulaires et Dentaires, Groupe Physiopathologie des Tissus Squelettiques et Ingénierie du Cartilage, Nantes, France
    J Bone Miner Res 24:1856-68. 2009

Collaborators

Detail Information

Publications13

  1. pmc Mice with hypomorphic expression of the sodium-phosphate cotransporter PiT1/Slc20a1 have an unexpected normal bone mineralization
    Annabelle Bourgine
    Institut National de la Sante et de la Recherche Medicale, U791, LIOAD, STEP group Skeletal Tissue Engineering and Physiopathology, Nantes, France
    PLoS ONE 8:e65979. 2013
    ..Whether this may contribute to the absence of bone mineralization defects remains to be further deciphered...
  2. pmc The phosphate transporter PiT1 (Slc20a1) revealed as a new essential gene for mouse liver development
    Laurent Beck
    INSERM, U845, Centre de Recherche Croissance et Signalisation, Paris, France
    PLoS ONE 5:e9148. 2010
    ..Although the importance of PiT1 in mineralizing processes have been demonstrated in vitro in osteoblasts, chondrocytes and vascular smooth muscle cells, in vivo evidence is missing...
  3. pmc Identification of a novel function of PiT1 critical for cell proliferation and independent of its phosphate transport activity
    Laurent Beck
    Growth and Signalling Research Center, INSERM, U845, F 75015 Paris
    J Biol Chem 284:31363-74. 2009
    ..This study is the first to describe the effects of a P(i) transporter in cell proliferation, tumor growth, and cell signaling...
  4. pmc A new human NHERF1 mutation decreases renal phosphate transporter NPT2a expression by a PTH-independent mechanism
    Marie Courbebaisse
    Faculte de Medecine, Universite Paris Descartes, Paris, France
    PLoS ONE 7:e34764. 2012
    ..We have recently identified mutations in NHERF1 that decrease renal phosphate reabsorption by increasing PTH-induced cAMP production in the renal proximal tubule...
  5. doi request reprint EKLF-driven PIT1 expression is critical for mouse erythroid maturation in vivo and in vitro
    Anne Forand
    INSERM U845, Paris, France
    Blood 121:666-78. 2013
    ..This is the first demonstration of a physiologic involvement of PIT1 in erythroid maturation in vivo...
  6. doi request reprint The emergence of phosphate as a specific signaling molecule in bone and other cell types in mammals
    Solmaz Khoshniat
    Centre for Osteoarticular and Dental Tissue Engineering, INSERM, U, Nantes, France
    Cell Mol Life Sci 68:205-18. 2011
    ..The involvement of various signaling pathways (ERK1/2), transcription factors (Fra-1, Runx2) and phosphate transporters (PiT1, PiT2) is discussed...
  7. doi request reprint NHERF1 mutations and responsiveness of renal parathyroid hormone
    Zoubida Karim
    INSERM Unité 845, Universite Paris Descartes, Faculte de Medecine, Paris, France
    N Engl J Med 359:1128-35. 2008
    ..These NHERF1 mutations suggest a previously unrecognized cause of renal phosphate loss in humans...
  8. pmc Identification of a novel transport-independent function of PiT1/SLC20A1 in the regulation of TNF-induced apoptosis
    Christine Salaun
    Growth and Signaling Research Center, INSERM U845, F 75015 Paris, France
    J Biol Chem 285:34408-18. 2010
    ..JNK activity is actually involved in PiT1-depleted cell death because specific JNK inhibitors delay apoptosis...
  9. ncbi request reprint Recent findings in phosphate homeostasis
    Dominique Prie
    Inserm U 426 et Institut Fédératif de Recherche 02, Faculty of Medicine, Xavier Bichat, Paris, France
    Curr Opin Nephrol Hypertens 14:318-24. 2005
    ..We summarize the most recent findings on the proteins that interact with sodium/inorganic phosphate (Na/Pi) cotransporters, the factors that regulate Pi homeostasis and their role in pathology...
  10. doi request reprint Phosphate-dependent regulation of MGP in osteoblasts: role of ERK1/2 and Fra-1
    Marion Julien
    INSERM, U 791, Laboratoire d Ingénierie des Tissus Ostéo Articulaires et Dentaires, Groupe Physiopathologie des Tissus Squelettiques et Ingénierie du Cartilage, Nantes, France
    J Bone Miner Res 24:1856-68. 2009
    ..These data show, for the first time, that Pi regulates MGP expression in osteoblasts through the ERK1/2-Fra-1 pathway...
  11. ncbi request reprint Sodium-phosphate cotransporters, nephrolithiasis and bone demineralization
    Dominique Prie
    Inserm U 426 et Institut Fédératif de Recherche 02, Faculte de Medecine Xavier Bichat, 16 rue Henri Huchard, 75018 Paris, France
    Curr Opin Nephrol Hypertens 13:675-81. 2004
    ..We discuss how recent findings obtained in disorders of phosphate metabolism in humans and in animal models have provided insights into the pathogenesis of renal stone formation and bone demineralization...
  12. ncbi request reprint Hypophosphatemia and calcium nephrolithiasis
    Dominique Prie
    Department of Physiology and INSERM U 426, Faculte de Medecine Xavier Bichat, Universite Denis Diderot, Paris, France
    Nephron Exp Nephrol 98:e50-4. 2004
    ..Similar features are observed during invalidation of NHERF or in case of overproduction of FGF23. These observations highlight the importance of phosphate homeostasis in common diseases such as renal stones or bone loss...
  13. doi request reprint Characterization of the mouse ClC-K1/Barttin chloride channel
    Sebastien l'Hoste
    UPMC Univ Paris 06, UMRS 872, Laboratoire de Génomique, Physiologie et Physiopathologie Rénales, F 75005 Paris, France INSERM, UMRS 872, Laboratoire de Génomique, Physiologie et Physiopathologie Rénales, F 75005 Paris, France CNRS, ERL 7226, Laboratoire de Génomique, Physiologie et Physiopathologie Rénales, F 75005, Paris, France
    Biochim Biophys Acta 1828:2399-409. 2013
    ..J Membr. Biol, 1990, 113:253-260). ..