Laurent Beck

Summary

Country: France

Publications

  1. pmc Identification of a novel function of PiT1 critical for cell proliferation and independent of its phosphate transport activity
    Laurent Beck
    Growth and Signalling Research Center, INSERM, U845, F 75015 Paris
    J Biol Chem 284:31363-74. 2009
  2. pmc The phosphate transporter PiT1 (Slc20a1) revealed as a new essential gene for mouse liver development
    Laurent Beck
    INSERM, U845, Centre de Recherche Croissance et Signalisation, Paris, France
    PLoS ONE 5:e9148. 2010
  3. pmc A new human NHERF1 mutation decreases renal phosphate transporter NPT2a expression by a PTH-independent mechanism
    Marie Courbebaisse
    Faculte de Medecine, Universite Paris Descartes, Paris, France
    PLoS ONE 7:e34764. 2012
  4. doi request reprint EKLF-driven PIT1 expression is critical for mouse erythroid maturation in vivo and in vitro
    Anne Forand
    INSERM U845, Paris, France
    Blood 121:666-78. 2013
  5. doi request reprint NHERF1 mutations and responsiveness of renal parathyroid hormone
    Zoubida Karim
    INSERM Unité 845, Universite Paris Descartes, Faculte de Medecine, Paris, France
    N Engl J Med 359:1128-35. 2008
  6. pmc Identification of a novel transport-independent function of PiT1/SLC20A1 in the regulation of TNF-induced apoptosis
    Christine Salaun
    Growth and Signaling Research Center, INSERM U845, F 75015 Paris, France
    J Biol Chem 285:34408-18. 2010
  7. doi request reprint The emergence of phosphate as a specific signaling molecule in bone and other cell types in mammals
    Solmaz Khoshniat
    Centre for Osteoarticular and Dental Tissue Engineering, INSERM, U, Nantes, France
    Cell Mol Life Sci 68:205-18. 2011
  8. ncbi request reprint Recent findings in phosphate homeostasis
    Dominique Prie
    Inserm U 426 et Institut Fédératif de Recherche 02, Faculty of Medicine, Xavier Bichat, Paris, France
    Curr Opin Nephrol Hypertens 14:318-24. 2005
  9. ncbi request reprint Sodium-phosphate cotransporters, nephrolithiasis and bone demineralization
    Dominique Prie
    Inserm U 426 et Institut Fédératif de Recherche 02, Faculte de Medecine Xavier Bichat, 16 rue Henri Huchard, 75018 Paris, France
    Curr Opin Nephrol Hypertens 13:675-81. 2004
  10. ncbi request reprint Hypophosphatemia and calcium nephrolithiasis
    Dominique Prie
    Department of Physiology and INSERM U 426, Faculte de Medecine Xavier Bichat, Universite Denis Diderot, Paris, France
    Nephron Exp Nephrol 98:e50-4. 2004

Collaborators

  • Dominique Prie
  • Marie Courbebaisse
  • Pablo Urena
  • Laure Coulombel
  • Solmaz Khoshniat
  • Christine Leroy
  • Gerard Friedlander
  • Marion Julien
  • Anne Forand
  • Valérie Boitez
  • Alice Rousseau
  • Jerome Guicheux
  • Pierre Weiss
  • Christine Salaun
  • Zoubida Karim
  • Olivier Hermine
  • Geneviève Courtois
  • Isabelle Cohen
  • Annabelle Bourgine
  • Aline Lacreusette
  • Aline Bozec
  • Yohann Wittrant
  • Maithé Gatius
  • David Magne
  • Erwin F Wagner
  • Martial Masson
  • Caroline Silve
  • Pablo Urena-Torres
  • Bernard Grandchamp
  • Benedicte Gerard
  • Rohia Alili
  • Gabrielle Planelles
  • Naziha Bakouh

Detail Information

Publications11

  1. pmc Identification of a novel function of PiT1 critical for cell proliferation and independent of its phosphate transport activity
    Laurent Beck
    Growth and Signalling Research Center, INSERM, U845, F 75015 Paris
    J Biol Chem 284:31363-74. 2009
    ..This study is the first to describe the effects of a P(i) transporter in cell proliferation, tumor growth, and cell signaling...
  2. pmc The phosphate transporter PiT1 (Slc20a1) revealed as a new essential gene for mouse liver development
    Laurent Beck
    INSERM, U845, Centre de Recherche Croissance et Signalisation, Paris, France
    PLoS ONE 5:e9148. 2010
    ..Although the importance of PiT1 in mineralizing processes have been demonstrated in vitro in osteoblasts, chondrocytes and vascular smooth muscle cells, in vivo evidence is missing...
  3. pmc A new human NHERF1 mutation decreases renal phosphate transporter NPT2a expression by a PTH-independent mechanism
    Marie Courbebaisse
    Faculte de Medecine, Universite Paris Descartes, Paris, France
    PLoS ONE 7:e34764. 2012
    ..We have recently identified mutations in NHERF1 that decrease renal phosphate reabsorption by increasing PTH-induced cAMP production in the renal proximal tubule...
  4. doi request reprint EKLF-driven PIT1 expression is critical for mouse erythroid maturation in vivo and in vitro
    Anne Forand
    INSERM U845, Paris, France
    Blood 121:666-78. 2013
    ..This is the first demonstration of a physiologic involvement of PIT1 in erythroid maturation in vivo...
  5. doi request reprint NHERF1 mutations and responsiveness of renal parathyroid hormone
    Zoubida Karim
    INSERM Unité 845, Universite Paris Descartes, Faculte de Medecine, Paris, France
    N Engl J Med 359:1128-35. 2008
    ..These NHERF1 mutations suggest a previously unrecognized cause of renal phosphate loss in humans...
  6. pmc Identification of a novel transport-independent function of PiT1/SLC20A1 in the regulation of TNF-induced apoptosis
    Christine Salaun
    Growth and Signaling Research Center, INSERM U845, F 75015 Paris, France
    J Biol Chem 285:34408-18. 2010
    ..JNK activity is actually involved in PiT1-depleted cell death because specific JNK inhibitors delay apoptosis...
  7. doi request reprint The emergence of phosphate as a specific signaling molecule in bone and other cell types in mammals
    Solmaz Khoshniat
    Centre for Osteoarticular and Dental Tissue Engineering, INSERM, U, Nantes, France
    Cell Mol Life Sci 68:205-18. 2011
    ..The involvement of various signaling pathways (ERK1/2), transcription factors (Fra-1, Runx2) and phosphate transporters (PiT1, PiT2) is discussed...
  8. ncbi request reprint Recent findings in phosphate homeostasis
    Dominique Prie
    Inserm U 426 et Institut Fédératif de Recherche 02, Faculty of Medicine, Xavier Bichat, Paris, France
    Curr Opin Nephrol Hypertens 14:318-24. 2005
    ..We summarize the most recent findings on the proteins that interact with sodium/inorganic phosphate (Na/Pi) cotransporters, the factors that regulate Pi homeostasis and their role in pathology...
  9. ncbi request reprint Sodium-phosphate cotransporters, nephrolithiasis and bone demineralization
    Dominique Prie
    Inserm U 426 et Institut Fédératif de Recherche 02, Faculte de Medecine Xavier Bichat, 16 rue Henri Huchard, 75018 Paris, France
    Curr Opin Nephrol Hypertens 13:675-81. 2004
    ..We discuss how recent findings obtained in disorders of phosphate metabolism in humans and in animal models have provided insights into the pathogenesis of renal stone formation and bone demineralization...
  10. ncbi request reprint Hypophosphatemia and calcium nephrolithiasis
    Dominique Prie
    Department of Physiology and INSERM U 426, Faculte de Medecine Xavier Bichat, Universite Denis Diderot, Paris, France
    Nephron Exp Nephrol 98:e50-4. 2004
    ..Similar features are observed during invalidation of NHERF or in case of overproduction of FGF23. These observations highlight the importance of phosphate homeostasis in common diseases such as renal stones or bone loss...
  11. doi request reprint Phosphate-dependent regulation of MGP in osteoblasts: role of ERK1/2 and Fra-1
    Marion Julien
    INSERM, U 791, Laboratoire d Ingénierie des Tissus Ostéo Articulaires et Dentaires, Groupe Physiopathologie des Tissus Squelettiques et Ingénierie du Cartilage, Nantes, France
    J Bone Miner Res 24:1856-68. 2009
    ..These data show, for the first time, that Pi regulates MGP expression in osteoblasts through the ERK1/2-Fra-1 pathway...