- Detection of functional ricin by immunoaffinity and liquid chromatography-tandem mass spectrometryF Becher
CEA, Service de Pharmacologie et d Immunologie, 91191 Gif sur Yvette, France and LCSOB UMR 7613 CNRS, Universite Pierre et Marie Curie, Paris, France
Anal Chem 79:659-65. 2007..1 ng/mL (1.56 pM) after concentration of the toxin from a 500 microL sample size. The variability of the assay was 10%. Finally, the method was applied successfully to milk and tap or bottled water samples...
- Direct determination of phosphorylated intracellular anabolites of stavudine (d4T) by liquid chromatography/tandem mass spectrometryA Pruvost
CEA, Pharmacology and Immunology Unit, DSV/DRM, CEA/Saclay, 91191 Gif-sur-Yvette Cedex, France
Rapid Commun Mass Spectrom 15:1401-8. 2001..For the first time, the chain terminator ratio (d4T-TP/dT-TP) could be directly measured. This method can be used simply and routinely on more than 35 samples per day. Extension to other nucleoside analogues is under development...
- Quantification of small therapeutic proteins in plasma by liquid chromatography-tandem mass spectrometry: application to an elastase inhibitor EPI-hNE4F Becher
CEA, Service de Pharmacologie et d Immunologie, 91191 Gif sur Yvette, France
Anal Chem 78:2306-13. 2006..Intra- and interassay precision and accuracy were below 15%. No matrix effect was detected...