Carole Beaumont

Summary

Country: France

Publications

  1. doi request reprint Recycling iron in normal and pathological states
    Carole Beaumont
    INSERM U773, Centre de recherche Biomedicale Bichat Beaujon, Université Paris Diderot Paris, UFR de Medecine Site Bichat, Paris, France
    Semin Hematol 46:328-38. 2009
  2. pmc Iron refractory iron deficiency anemia
    Luigia De Falco
    CEINGE, Biotecnologie Avanzate, Naples, Italy
    Haematologica 98:845-53. 2013
  3. doi request reprint [Iron metabolism: State of the art]
    C Beaumont
    INSERM U773, Universite Paris Diderot, site Bichat, 16, rue Henri Huchard, 75018 Paris, France
    Rev Med Interne 34:17-25. 2013
  4. doi request reprint Efficacy and toxicity of intravenous iron in a mouse model of critical care anemia*
    Nicholas Heming
    INSERM U773, Univ Paris Diderot, Sorbonne Paris Cité, site Bichat, Paris, France
    Crit Care Med 40:2141-8. 2012
  5. ncbi request reprint Genetic study of variation in normal mouse iron homeostasis reveals ceruloplasmin as an HFE-hemochromatosis modifier gene
    Laurent Gouya
    INSERM U773, Centre de Recherche Biomedicale Bichat Beaujon CRB3, Universite Paris 7 Denis Diderot, site Bichat, Paris, France
    Gastroenterology 132:679-86. 2007
  6. ncbi request reprint A physiological model to study iron recycling in macrophages
    Constance Delaby
    Inserm U656, Fer et synthèse d hème, Genetique, Physiologie et Pathologie, Faculte de Medecine Xavier Bichat, 16, rue Henri Huchard, 75018 Paris, France
    Exp Cell Res 310:43-53. 2005
  7. doi request reprint Erythropoietin stimulates spleen BMP4-dependent stress erythropoiesis and partially corrects anemia in a mouse model of generalized inflammation
    Sarah Millot
    INSERM U773, Centre de recherche Biomedicale Bichat Beaujon, Universite Paris Diderot, Paris, France
    Blood 116:6072-81. 2010
  8. doi request reprint Phlebotomies or erythropoietin injections allow mobilization of iron stores in a mouse model mimicking intensive care anemia
    Sigismond Lasocki
    INSERM U773, Centre de recherche Biomedicale Bichat Beaujon, Paris, France
    Crit Care Med 36:2388-94. 2008
  9. pmc Wild-type and mutant ferroportins do not form oligomers in transfected cells
    Ana Sofia Gonçalves
    INSERM, U773, 16 rue Henri Huchard, 75018 Paris, France
    Biochem J 396:265-75. 2006
  10. doi request reprint Inactive matriptase-2 mutants found in IRIDA patients still repress hepcidin in a transfection assay despite having lost their serine protease activity
    Flavia Guillem
    Universite Paris Diderot, Paris, France
    Hum Mutat 33:1388-96. 2012

Collaborators

Detail Information

Publications31

  1. doi request reprint Recycling iron in normal and pathological states
    Carole Beaumont
    INSERM U773, Centre de recherche Biomedicale Bichat Beaujon, Université Paris Diderot Paris, UFR de Medecine Site Bichat, Paris, France
    Semin Hematol 46:328-38. 2009
    ..This review will focus particularly on the mechanisms involved in iron recycling by macrophages and summarize the pathological conditions perturbing this process...
  2. pmc Iron refractory iron deficiency anemia
    Luigia De Falco
    CEINGE, Biotecnologie Avanzate, Naples, Italy
    Haematologica 98:845-53. 2013
    ....
  3. doi request reprint [Iron metabolism: State of the art]
    C Beaumont
    INSERM U773, Universite Paris Diderot, site Bichat, 16, rue Henri Huchard, 75018 Paris, France
    Rev Med Interne 34:17-25. 2013
    ..The validation of hepcidin assays in a near future will allow identifying the patients most likely to benefit from intravenous iron therapy...
  4. doi request reprint Efficacy and toxicity of intravenous iron in a mouse model of critical care anemia*
    Nicholas Heming
    INSERM U773, Univ Paris Diderot, Sorbonne Paris Cité, site Bichat, Paris, France
    Crit Care Med 40:2141-8. 2012
    ..The objective of this work was to determine the efficacy and toxicity of iron administration using a mouse model mimicking critical care anemia as well as a model of acute septicemia...
  5. ncbi request reprint Genetic study of variation in normal mouse iron homeostasis reveals ceruloplasmin as an HFE-hemochromatosis modifier gene
    Laurent Gouya
    INSERM U773, Centre de Recherche Biomedicale Bichat Beaujon CRB3, Universite Paris 7 Denis Diderot, site Bichat, Paris, France
    Gastroenterology 132:679-86. 2007
    ..However, penetrance of this mutation is incomplete, suggesting that other genetic and environmental factors contribute to its differential biologic or clinical expression...
  6. ncbi request reprint A physiological model to study iron recycling in macrophages
    Constance Delaby
    Inserm U656, Fer et synthèse d hème, Genetique, Physiologie et Pathologie, Faculte de Medecine Xavier Bichat, 16, rue Henri Huchard, 75018 Paris, France
    Exp Cell Res 310:43-53. 2005
    ..However, phagocytosis of artificially-aged red blood cells seems to repress the proinflammatory response of macrophages...
  7. doi request reprint Erythropoietin stimulates spleen BMP4-dependent stress erythropoiesis and partially corrects anemia in a mouse model of generalized inflammation
    Sarah Millot
    INSERM U773, Centre de recherche Biomedicale Bichat Beaujon, Universite Paris Diderot, Paris, France
    Blood 116:6072-81. 2010
    ..It allows only partial recovery of anemia, probably because of peripheral destruction of mature red cells. It is not clear whether similar BMP4-dependent stress erythropoiesis can occur in human bone marrow after Epo injections...
  8. doi request reprint Phlebotomies or erythropoietin injections allow mobilization of iron stores in a mouse model mimicking intensive care anemia
    Sigismond Lasocki
    INSERM U773, Centre de recherche Biomedicale Bichat Beaujon, Paris, France
    Crit Care Med 36:2388-94. 2008
    ..These two mechanisms have opposite effects on iron homeostasis, especially on the expression of the iron regulatory hormone hepcidin. We developed a mouse model mimicking the intensive care anemia to explore iron homeostasis...
  9. pmc Wild-type and mutant ferroportins do not form oligomers in transfected cells
    Ana Sofia Gonçalves
    INSERM, U773, 16 rue Henri Huchard, 75018 Paris, France
    Biochem J 396:265-75. 2006
    ....
  10. doi request reprint Inactive matriptase-2 mutants found in IRIDA patients still repress hepcidin in a transfection assay despite having lost their serine protease activity
    Flavia Guillem
    Universite Paris Diderot, Paris, France
    Hum Mutat 33:1388-96. 2012
    ..This simple test can be used to determine whether a sequence variation leading to an amino acid substitution is functionally relevant or not...
  11. doi request reprint Intestinal DMT1 cotransporter is down-regulated by hepcidin via proteasome internalization and degradation
    Carole Brasse-Lagnel
    INSERM U773, Centre de Recherche Biomedicale Bichat Beaujon CRB3, Universite Paris Diderot, site Bichat, Paris, France
    Gastroenterology 140:1261-1271.e1. 2011
    ..We studied human polarized intestinal (Caco-2/TC7) cells and mouse duodenal segments, ex vivo, to investigate the molecular mechanisms by which hepcidin down-regulates intestinal transepithelial iron transport...
  12. doi request reprint Protoporphyrin retention in hepatocytes and Kupffer cells prevents sclerosing cholangitis in erythropoietic protoporphyria mouse model
    Said Lyoumi
    INSERM U773, Centre de Recherche Biomedicale Bichat Beaujon CRB3, Universite Paris Diderot, site Bichat, Centre de Référence des Maladies Inflammatoires des Voies Biliaires, service d Hépatologie Gastroentérologie, Hopital Saint Antoine, Paris, France
    Gastroenterology 141:1509-19, 1519.e1-3. 2011
    ..We characterized protoporphyrin-IX (PPIX)-linked hepatobiliary disease in BALB/c and C57BL/6 (Fechm1Pas) mice with mutations in ferrochelatase as models for EPP...
  13. ncbi request reprint [Serum hepcidin assay in 2011: where do we stand?]
    Constance Delaby
    INSERM U773, Centre de Recherche Biomedicale Bichat Beaujon CRB3, Universite Paris Diderot Paris 7, UFR de Medecine Site Bichat, Paris, France
    Ann Biol Clin (Paris) 70:377-86. 2012
    ..This article focuses on the molecular mechanisms of hepcidin regulation and reviews the various methods of hepcidin quantification, describing the advantages and limitations of each one of them...
  14. doi request reprint Diagnostic accuracy of serum hepcidin for iron deficiency in critically ill patients with anemia
    Sigismond Lasocki
    Service de Réanimation Chirugicale, département d anesthésie réanimation chirurgicale, AP HP, CHU Bichat Claude Bernard, université Paris 7 Diderot, 46, rue Henri Huchard, 75877, Paris Cedex 18, France
    Intensive Care Med 36:1044-8. 2010
    ..We conducted a prospective observational study to determine the cutoff value and diagnostic accuracy of hepcidin levels for detecting ID in critically ill anemic patients...
  15. doi request reprint A novel type of congenital hypochromic anemia associated with a nonsense mutation in the STEAP3/TSAP6 gene
    Bernard Grandchamp
    Assistance Publique des Hopitaux de Paris, Hopital Bichat, Laboratoire de Biochimie hormonale et génétique, Paris, France
    Blood 118:6660-6. 2011
    ....
  16. ncbi request reprint Transferrin receptor 1 mRNA is downregulated in placenta of hepcidin transgenic embryos
    Marie Elise Martin
    INSERM U409, Faculte de Medecine X Bichat, Institut Federatif de Recherche 02, 16 rue Henri Huchard, 75018 Paris, France
    FEBS Lett 574:187-91. 2004
    ..Taken together, these results suggest that hepcidin action on placenta is mostly through transcriptional downregulation of the iron uptake machinery...
  17. pmc A new missense mutation in the L ferritin coding sequence associated with elevated levels of glycosylated ferritin in serum and absence of iron overload
    Caroline Kannengiesser
    AP HP, Service de Génétique et Biochimie hormonale, Hopital Bichat Claude Bernard, Paris, France
    Haematologica 94:335-9. 2009
    ..Genetic causes of hyperferritinemia associated to early cataract include mutations in the iron responsive element in the 5' untranslated region of the L ferritin mRNA, responsible for the hereditary hyperferritinemia cataract syndrome...
  18. ncbi request reprint Presence of the iron exporter ferroportin at the plasma membrane of macrophages is enhanced by iron loading and down-regulated by hepcidin
    Constance Delaby
    Institut National de la Santé et de la Recherche Médicale INSERM U656, Fer et synthèse d hème, Genetique, Physiologie et Pathologie, Faculte de Medecine Xavier Bichat, Paris, France
    Blood 106:3979-84. 2005
    ..These data are consistent with a direct iron export by ferroportin through the plasma membrane of macrophages and strongly support an efficient posttranscriptional down-regulation of ferroportin by hepcidin in these cells...
  19. doi request reprint Iron metabolism in patients with anorexia nervosa: elevated serum hepcidin concentrations in the absence of inflammation
    Solesne Papillard-Marechal
    AP HP, Service de Pediatrie, Hopital Bichat, Paris, France
    Am J Clin Nutr 95:548-54. 2012
    ..Only a few studies based on small cohorts have been carried out on iron status in anorexia nervosa (AN) patients...
  20. doi request reprint Two nonsense mutations in the TMPRSS6 gene in a patient with microcytic anemia and iron deficiency
    Flavia Guillem
    Assistance publique des Hôpitaux de Paris APHP, Laboratoire de Génétique et Biochimie Hormonale, Hopital Bichat, Paris, France
    Blood 112:2089-91. 2008
    ....
  21. pmc Missense SLC25A38 variations play an important role in autosomal recessive inherited sideroblastic anemia
    Caroline Kannengiesser
    AP HP, Service de Biochimie Génétique et Hormonale, Hopital Bichat, Paris, INSERM, Centre de recherche Biomedicale Bichat Beaujon, Universite Paris Diderot, France
    Haematologica 96:808-13. 2011
    ..Further evaluation of the importance of this gene was required to estimate the proportion of patients affected and to gain further insight into the range and types of variations involved...
  22. ncbi request reprint Increased plasma transferrin, altered body iron distribution, and microcytic hypochromic anemia in ferrochelatase-deficient mice
    Said Lyoumi
    INSERM U773, Paris, France
    Blood 109:811-8. 2007
    ....
  23. ncbi request reprint Two new human DMT1 gene mutations in a patient with microcytic anemia, low ferritinemia, and liver iron overload
    Carole Beaumont
    INSERM U773, Centre de Recherche Biomedicale Bichat Beaujon CRB3, BP 416, 16 rue Henri Huchard, F 75018 Paris, France
    Blood 107:4168-70. 2006
    ....
  24. ncbi request reprint Monoclonal immunoglobulin with antitransferrin activity: A rare cause of hypersideremia with increased transferrin saturation
    Marie Alexandra Alyanakian
    Université Paris 5 René Descartes Assistance Publique Hôpitaux de Paris AP HP, Laboratoire d Immunologie, Hopital Necker, Paris, France
    Blood 109:359-61. 2007
    ..The antitransferrin activity of monoclonal antibody should be added to the list of situations accounting for elevated serum iron with elevated transferrin saturation...
  25. ncbi request reprint Anemia after late introduction of sirolimus may correlate with biochemical evidence of a chronic inflammatory state
    Olivier Thaunat
    Department of Renal Transplantation, Hopital Necker Enfants Malades, Paris, France
    Transplantation 80:1212-9. 2005
    ..The responsibility of sirolimus (SRL) for postrenal transplant anemia has never been proven, because SRL is usually combined with myelotoxic drugs, and because of the high incidence of anemia in the posttransplant period...
  26. doi request reprint Light-induced retinal degeneration correlates with changes in iron metabolism gene expression, ferritin level, and aging
    Emilie Picard
    Institut National de la Sante et de la Recherche Medicale, U872, Paris, France
    Invest Ophthalmol Vis Sci 52:1261-74. 2011
    ..Retinal degeneration is associated with iron accumulation in several rodent models in which iron-regulating proteins are impaired. Oxidative stress is catalyzed by unbound iron...
  27. ncbi request reprint Ferroportin in erythroid cells: a protective mechanism?
    Carole Beaumont
    Inserm U656, Faculte X Bichat, Paris, France
    Haematologica 90:1585. 2005
  28. doi request reprint Sideroblastic anemia: molecular analysis of the ALAS2 gene in a series of 29 probands and functional studies of 10 missense mutations
    Sarah Ducamp
    INSERM, Centre de recherche Biomedicale Bichat Beaujon, Paris, France
    Hum Mutat 32:590-7. 2011
    ..Although most amino acid substitutions result in a clearly decreased enzymatic activity in vitro, a few mutations have a more subtle effect on the protein that is only revealed by in vitro tests under specific conditions...
  29. ncbi request reprint [Molecular mechanisms of iron homeostasis]
    Carole Beaumont
    INSERM U 409, Faculte de Medecine Xavier Bichat, BP 416, 16, rue Henri Huchard, 75870 Paris 18, France
    Med Sci (Paris) 20:68-72. 2004
    ..These results open new therapeutic perspectives, especially with the possibility to use hepcidin or antagonists for the treatment of iron overload disorders...
  30. ncbi request reprint A neutralizing monoclonal antibody (mAb A24) directed against the transferrin receptor induces apoptosis of tumor T lymphocytes from ATL patients
    Ivan C Moura
    Institut National de la Santé et de la Recherche Médicale INSERM E 0225, Faculte de Medecine Xavier Bichat, Paris, France
    Blood 103:1838-45. 2004
    ..Therefore efficient therapeutic tools to treat acute forms of ATL might be derived from A24...
  31. pmc The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation
    Gael Nicolas
    Département de génétique, Developpement et Pathologie Moleculaire, Institut Cochin, INSERM, Centre National de la Recherche Scientifique, et Université René Descartes, Faculté de Médecine Cochin Port Royal, Paris, France
    J Clin Invest 110:1037-44. 2002
    ....