J P Bastard

Summary

Country: France

Publications

  1. ncbi request reprint Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss
    J P Bastard
    Service de Biochimie, Hopital de la Salpetriere, Paris, France
    J Clin Endocrinol Metab 85:3338-42. 2000
  2. ncbi request reprint Recent advances in the relationship between obesity, inflammation, and insulin resistance
    Jean Philippe Bastard
    INSERM U680, Faculte de Medecine Pierre et Marie Curie, site Saint Antoine, Universite Pierre et Marie Curie, Paris 6 et Service de Biochimie et Hormonologie, Hopital Tenon, AP HP, 75970 Paris Cedex 20, France
    Eur Cytokine Netw 17:4-12. 2006
  3. ncbi request reprint Relationship between plasma plasminogen activator inhibitor 1 and insulin resistance
    J P Bastard
    Service de Biochimie et Hormonologie, Hopital Tenon, Paris, France
    Diabetes Metab Res Rev 16:192-201. 2000
  4. ncbi request reprint [Insulin resistance and adipose tissue gene expression in humans]
    J P Bastard
    Service de Biochimie et Hormonologie, Hopital Tenon, 4, rue de la Chine, 75970 Paris
    Ann Biol Clin (Paris) 62:25-31. 2004
  5. ncbi request reprint What kind of simple fasting index should be used to estimate insulin sensitivity in humans?
    J P Bastard
    Service de Biochimie et Hormonologie, Hopital Tenon AP HP, Paris, France
    Diabetes Metab 29:285-8. 2003
  6. ncbi request reprint Variations in plasma soluble tumour necrosis factor receptors after diet-induced weight loss in obesity
    J P Bastard
    Service de Biochimie, H pital de la Salpêtrière, Paris, France
    Diabetes Obes Metab 2:323-5. 2000
  7. ncbi request reprint Adipose tissue IL-6 content correlates with resistance to insulin activation of glucose uptake both in vivo and in vitro
    Jean Philippe Bastard
    Service de Biochimie et Hormonologie, Hôpital Tenon Rothschild, Assistance Publique Hopitaux de Paris AP HP, 75020 Paris, France
    J Clin Endocrinol Metab 87:2084-9. 2002
  8. ncbi request reprint Systemic low-grade inflammation is related to both circulating and adipose tissue TNFalpha, leptin and IL-6 levels in obese women
    M Maachi
    Service de Biochimie et Hormonologie, Hopital Tenon, AP HP, France
    Int J Obes Relat Metab Disord 28:993-7. 2004
  9. ncbi request reprint Increased adiponectin receptor-1 expression in adipose tissue of impaired glucose-tolerant obese subjects during weight loss
    M J Kim
    INSERM U 680, Faculte de Medecine, Universite Pierre et Marie Curie, 75012 Paris, France
    Eur J Endocrinol 155:161-5. 2006
  10. ncbi request reprint Subcutaneous adipose tissue expression of plasminogen activator inhibitor-1 gene during very low calorie diet in obese subjects
    J P Bastard
    Service de Biochimie, Hopital de la Salpetriere, AP HP, Paris
    Int J Obes Relat Metab Disord 24:70-4. 2000

Collaborators

Detail Information

Publications47

  1. ncbi request reprint Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss
    J P Bastard
    Service de Biochimie, Hopital de la Salpetriere, Paris, France
    J Clin Endocrinol Metab 85:3338-42. 2000
    ..The reduced production and serum concentrations after weight loss could play a role in the improved sensitivity to insulin observed in these patients...
  2. ncbi request reprint Recent advances in the relationship between obesity, inflammation, and insulin resistance
    Jean Philippe Bastard
    INSERM U680, Faculte de Medecine Pierre et Marie Curie, site Saint Antoine, Universite Pierre et Marie Curie, Paris 6 et Service de Biochimie et Hormonologie, Hopital Tenon, AP HP, 75970 Paris Cedex 20, France
    Eur Cytokine Netw 17:4-12. 2006
    ..Thus, it can be considered that obesity corresponds to a sub-clinical inflammatory condition that promotes the production of pro-inflammatory factors involved in the pathogenesis of insulin resistance...
  3. ncbi request reprint Relationship between plasma plasminogen activator inhibitor 1 and insulin resistance
    J P Bastard
    Service de Biochimie et Hormonologie, Hopital Tenon, Paris, France
    Diabetes Metab Res Rev 16:192-201. 2000
    ..These mechanisms may involve several metabolic disorders such as hyperinsulinemia, dyslipidemia, impaired glucose tolerance and hypertension, which would favor PAI-1 synthesis and release from different cell types...
  4. ncbi request reprint [Insulin resistance and adipose tissue gene expression in humans]
    J P Bastard
    Service de Biochimie et Hormonologie, Hopital Tenon, 4, rue de la Chine, 75970 Paris
    Ann Biol Clin (Paris) 62:25-31. 2004
    ..These findings suggest that adipose tissue is involved in insulin resistance in humans particularly via adipocytokine secretion...
  5. ncbi request reprint What kind of simple fasting index should be used to estimate insulin sensitivity in humans?
    J P Bastard
    Service de Biochimie et Hormonologie, Hopital Tenon AP HP, Paris, France
    Diabetes Metab 29:285-8. 2003
    ....
  6. ncbi request reprint Variations in plasma soluble tumour necrosis factor receptors after diet-induced weight loss in obesity
    J P Bastard
    Service de Biochimie, H pital de la Salpêtrière, Paris, France
    Diabetes Obes Metab 2:323-5. 2000
    ..5 kg), this result supports the emerging concept that adipose tissue can produce significant amounts of sTNFR-I and that this production can be modified by weight loss in human obesity...
  7. ncbi request reprint Adipose tissue IL-6 content correlates with resistance to insulin activation of glucose uptake both in vivo and in vitro
    Jean Philippe Bastard
    Service de Biochimie et Hormonologie, Hôpital Tenon Rothschild, Assistance Publique Hopitaux de Paris AP HP, 75020 Paris, France
    J Clin Endocrinol Metab 87:2084-9. 2002
    ..In conclusion, increased IL-6 production by sc adipose cells might participate to the insulin-resistant state observed in human obesity...
  8. ncbi request reprint Systemic low-grade inflammation is related to both circulating and adipose tissue TNFalpha, leptin and IL-6 levels in obese women
    M Maachi
    Service de Biochimie et Hormonologie, Hopital Tenon, AP HP, France
    Int J Obes Relat Metab Disord 28:993-7. 2004
    ..We assessed the relationships between four circulating acute phase proteins and the circulating and adipose tissue levels of three adipocytokines...
  9. ncbi request reprint Increased adiponectin receptor-1 expression in adipose tissue of impaired glucose-tolerant obese subjects during weight loss
    M J Kim
    INSERM U 680, Faculte de Medecine, Universite Pierre et Marie Curie, 75012 Paris, France
    Eur J Endocrinol 155:161-5. 2006
    ....
  10. ncbi request reprint Subcutaneous adipose tissue expression of plasminogen activator inhibitor-1 gene during very low calorie diet in obese subjects
    J P Bastard
    Service de Biochimie, Hopital de la Salpetriere, AP HP, Paris
    Int J Obes Relat Metab Disord 24:70-4. 2000
    ..To determine whether changes in subcutaneous adipose tissue plasminogen activator inhibitor-1 (PAI-1) expression influence plasma PAI-1 level during weight loss in obese humans...
  11. ncbi request reprint Subcutaneous adipose tissue expression of tumour necrosis factor-alpha is not associated with whole body insulin resistance in obese nondiabetic or in type-2 diabetic subjects
    H A Koistinen
    Helsinki University Central Hospital, Finland Hôpital de la Salpétrière, Paris, France
    Eur J Clin Invest 30:302-10. 2000
    ..In the second part of the study we examined the relationship between adipose tissue TNFalpha mRNA levels and BMI in 81 nondiabetic subjects spanning a wide range of BMIs...
  12. ncbi request reprint Relationship between the hyperinsulinemic-euglycaemic clamp and a new simple index assessing insulin sensitivity in overweight and obese postmenopausal women
    J P Bastard
    Service de Biochimie et Hormonologie, Hopital Tenon, APHP, 75020 Paris, France
    Diabetes Metab 33:261-8. 2007
    ..The purpose of this study was to compare assessment of insulin sensitivity from hyperinsulinemic euglycaemic (HIEG) clamp with indexes derived from fasting and oral glucose tolerance test (OGTT)...
  13. doi request reprint Evaluation of two new surrogate indices including parameters not using insulin to assess insulin sensitivity/resistance in non-diabetic postmenopausal women: a MONET group study
    J P Bastard
    Service de Biochimie et Hormonologie, Hopital Tenon, AP HP, 75020 Paris, France
    Diabetes Metab 38:258-63. 2012
    ....
  14. ncbi request reprint Long-term treatment with interleukin-1beta induces insulin resistance in murine and human adipocytes
    C Lagathu
    INSERM, U680, Université Pierre et Marie Curie UPMC Paris 6, Faculty of Medicine, 27 rue Chaligny, 75012, Paris, France
    Diabetologia 49:2162-73. 2006
    ..Adipose tissue inflammation has recently been implicated in the pathogenesis of insulin resistance and is probably linked to high local levels of cytokines. IL1B, a proinflammatory cytokine, may participate in this alteration...
  15. ncbi request reprint Adipokines: the missing link between insulin resistance and obesity
    B Antuna-Puente
    INSERM U680, Faculte de Medecine Saint Antoine, Universite Pierre et Marie Curie Paris 6, 75012 Paris, France
    Diabetes Metab 34:2-11. 2008
    ....
  16. ncbi request reprint Surrogate indexes vs. euglycaemic-hyperinsulinemic clamp as an indicator of insulin resistance and cardiovascular risk factors in overweight and obese postmenopausal women
    F M Malita
    Department of Nutrition, Faculty of Medicine, University of Montreal, Montreal, Canada, and INSERM U680, Faculté de Médecine Saint Antoine et Service de Biochimie et Hormonologie, AP HP, Hopital Tenon, Paris, France
    Diabetes Metab 32:251-5. 2006
    ....
  17. doi request reprint Relevance of increased serum cystatin C to vascular alterations in obese children
    B Dubern
    Institute of Cardiometabolism and Nutrition, Paris, France INSERM, Paris, France
    Pediatr Obes 7:374-81. 2012
    ..Epidemiological studies report a positive relationship between serum cystatin C and cardiovascular outcomes in adults. Here, we tested the relevance of cystatin C as a biomarker for early vascular alterations in severely obese children...
  18. ncbi request reprint Interpretation of circulating C-reactive protein levels in adults: body mass index and gender are a must
    L Pieroni
    Laboratoire de Biochimie B, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Paris, France
    Diabetes Metab 29:133-8. 2003
    ..In the present study, we measured CRP in a healthy population with a wide range of BMI in order to appreciate the influence of overweight in the interpretation of CRP results in clinical use...
  19. ncbi request reprint Early increase of von Willebrand factor predicts adverse outcome in unstable coronary artery disease: beneficial effects of enoxaparin. French Investigators of the ESSENCE Trial
    G Montalescot
    Department of Cardiology, Pitie Salpetriere Hospital, Paris, France
    Circulation 98:294-9. 1998
    ....
  20. ncbi request reprint Consequences of the diabetic status on the oxidant/antioxidant balance
    D Bonnefont-Rousselot
    Laboratoire de Biochemie, Hopital de la Salpetriere, Paris France
    Diabetes Metab 26:163-76. 2000
    ..The aim of this paper was to review the consequences of the diabetic status on the oxidant/antioxidant balance...
  21. ncbi request reprint Diseases of adipose tissue: genetic and acquired lipodystrophies
    J Capeau
    INSERM U680, Saint Antoine Faculty of Medicine, Université Pierre et Marie Curie UPMC, Paris, France
    Biochem Soc Trans 33:1073-7. 2005
    ..Such syndromes help to understand the mechanisms involved in insulin resistance resulting from altered fat repartition and could benefit from insulin-sensitizing effects of lifestyle modifications or of specific medications...
  22. ncbi request reprint Association of acylated and nonacylated ghrelin with insulin sensitivity in overweight and obese postmenopausal women
    David H St-Pierre
    Departement de Nutrition, Universite de Montreal, Montreal, Quebec, Canada H3C 3J7
    J Clin Endocrinol Metab 92:264-9. 2007
    ....
  23. ncbi request reprint Point-counterpoint: Interleukin-6 does/does not have a beneficial role in insulin sensitivity and glucose homeostasis
    Jean Philippe Bastard
    J Appl Physiol 102:821-2; author reply 825. 2007
  24. ncbi request reprint Serum adipocytokines are related to lipodystrophy and metabolic disorders in HIV-infected men under antiretroviral therapy
    Corinne Vigouroux
    INSERM U 402, Faculte de Medecine Saint Antoine, Paris, France
    AIDS 17:1503-11. 2003
    ....
  25. ncbi request reprint Muscle and liver insulin resistance indexes derived from the oral glucose tolerance test: response to Abdul-Ghani et al
    Jean Philippe Bastard
    Diabetes Care 30:e83; author reply e84. 2007
  26. ncbi request reprint Some HIV antiretrovirals increase oxidative stress and alter chemokine, cytokine or adiponectin production in human adipocytes and macrophages
    Claire Lagathu
    INSERM, U680, Paris, France
    Antivir Ther 12:489-500. 2007
    ....
  27. ncbi request reprint Association of acylated ghrelin profiles with chronic inflammatory markers in overweight and obese postmenopausal women: a MONET study
    David H St-Pierre
    Departement de Nutrition, Universite de Montreal, Montreal, Quebec, Canada, H3T 1A8
    Eur J Endocrinol 157:419-26. 2007
    ....
  28. ncbi request reprint [Obesity, inflammation and insulin resistance: which role for adipokines]
    Barbara Antuna-Puente
    INSERM U680, Faculte de Medecine Saint Antoine, Universite Pierre et Marie Curie, Paris 6, Paris, France
    Therapie 62:285-92. 2007
    ..The release of adipokines by either adipocytes or adipose tissue-infiltrated macrophages leads to a chronic sub-inflammatory state that likely plays a major role in cardiovascular complications linked to obesity and insulin resistance...
  29. ncbi request reprint Cathepsin S, a novel biomarker of adiposity: relevance to atherogenesis
    Soraya Taleb
    INSERM Avenir, Paris, France
    FASEB J 19:1540-2. 2005
    ..Since this enzyme has been implicated in the development of atherosclerotic lesions, we propose that cathepsin S represents a molecular link between obesity and atherosclerosis...
  30. ncbi request reprint A 6-month interruption of antiretroviral therapy improves adipose tissue function in HIV-infected patients: the ANRS EP29 Lipostop Study
    Min Ji Kim
    INSERM, U680, Paris, F 75012, France
    Antivir Ther 12:1273-83. 2007
    ..To examine the reversibility of adipose tissue alterations in HIV-infected patients after a 6-month interruption of antiretroviral therapy (ART)...
  31. ncbi request reprint Eicosapentaenoic acid induces mRNA expression of peroxisome proliferator-activated receptor gamma
    Cécile Chambrier
    INSERM U449 and Human Nutrition Research Center of Lyon, R Laennec Faculty of Medicine, Claude Bernard Lyon 1 University, France
    Obes Res 10:518-25. 2002
    ..To verify whether polyunsaturated fatty acids (PUFAs) can regulate the expression of the nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma) in human adipose tissue...
  32. ncbi request reprint Modified quantitative insulin sensitivity check index is better correlated to hyperinsulinemic glucose clamp than other fasting-based index of insulin sensitivity in different insulin-resistant states
    Remi Rabasa-Lhoret
    Human Nutrition Research Centre of Lyon, Hopital Edouard Herriot, Lyon 69003, France
    J Clin Endocrinol Metab 88:4917-23. 2003
    ..However, QUICKI and revised QUICKI are good indexes that offer correlations similar to or higher than values obtained with log HOMA. Such indexes are simple tools to estimate insulin sensitivity appropriate for epidemiological studies...
  33. ncbi request reprint Altered fat differentiation and adipocytokine expression are inter-related and linked to morphological changes and insulin resistance in HIV-1-infected lipodystrophic patients
    Véronique Jan
    INSERM Research Unit 402, Faculty of Medicine Saint Antoine, Paris, France
    Antivir Ther 9:555-64. 2004
    ....
  34. ncbi request reprint [Relationship between obesity, inflammation and insulin resistance: new concepts]
    Bruno Feve
    Inserm U693, université Paris 11 et service d endocrinologie, CHU de Bicetre, 63, rue Gabriel Péri, 94270 Le Kremlin Bicetre, France
    C R Biol 329:587-97; discussion 653-5. 2006
    ....
  35. ncbi request reprint Antiretroviral drugs with adverse effects on adipocyte lipid metabolism and survival alter the expression and secretion of proinflammatory cytokines and adiponectin in vitro
    Claire Lagathu
    INSERM U402 and IFR65 Saint Antoine Faculty of Medicine and Biochemistry Department, Tenon Hospital, University Pierre et Marie Curie, Paris, France
    Antivir Ther 9:911-20. 2004
    ..We examined the direct effects of individual antiretrovirals on lipid metabolism and cytokine and adiponectin production by cultured adipocytes...
  36. ncbi request reprint Chronic interleukin-6 (IL-6) treatment increased IL-6 secretion and induced insulin resistance in adipocyte: prevention by rosiglitazone
    Claire Lagathu
    INSERM U 402 and IFR65 Saint Antoine Faculty of Medicine, Paris, France
    Biochem Biophys Res Commun 311:372-9. 2003
    ..Finally, the effects of IL-6 could be prevented by rosiglitazone, an insulin-sensitizing agent. Thus, IL-6 may play an important role in the set-up of insulin resistance in adipose cell...
  37. ncbi request reprint Patterns of proteinuria: urinary sodium dodecyl sulfate electrophoresis versus immunonephelometric protein marker measurement followed by interpretation with the knowledge-based system MDI-LabLink
    Mustapha Maachi
    INSERM Research Unit 402, Faculty of Medicine Saint Antoine, University Pierre and Marie Curie, Paris, France
    Clin Chem 50:1834-7. 2004
  38. ncbi request reprint HIV antiretroviral treatment alters adipokine expression and insulin sensitivity of adipose tissue in vitro and in vivo
    Claire Lagathu
    Inserm U 680 and IFR65, Universite Pierre et Marie Curie, Faculte de Medecine Saint Antoine, 27, rue Chaligny, 75571 Paris Cedex 12, France
    Biochimie 87:65-71. 2005
    ..Therefore, they could be involved in whole body insulin resistance and metabolic alterations in lipodystrophic HIV-1-infected patients...
  39. ncbi request reprint Suppressor of cytokine signaling 3 expression and insulin resistance in skeletal muscle of obese and type 2 diabetic patients
    Jennifer Rieusset
    INSERM U449 INRA U1235, Faculté de Médecine René Laennec, Rue G Paradin, F 69372 Lyon, Cedex 08, France
    Diabetes 53:2232-41. 2004
    ....
  40. ncbi request reprint Gene expression profiling of human skeletal muscle in response to stabilized weight loss
    Dominique Larrouy
    INSERM, U858, Obesity Research Laboratory, Institut de Medecine Moleculaire de Rangueil, Toulouse, France
    Am J Clin Nutr 88:125-32. 2008
    ..Whether this reduction remains after stabilized weight loss is still controversial, and the molecular mechanisms are unknown...
  41. ncbi request reprint Effect of pioglitazone on HIV-1-related lipodystrophy: a randomized double-blind placebo-controlled trial (ANRS 113)
    Laurence Slama
    Department of Infectious and Tropical Diseases, Tenon Hospital, Paris, F 75020 France
    Antivir Ther 13:67-76. 2008
    ..Although thiazolidinediones have been shown to increase subcutaneous fat in congenital lipodystrophy, rosiglitazone did not show convincing results in HIV lipoatrophy. We assess a potential specific effect of pioglitazone in this setting...
  42. ncbi request reprint The metabolically healthy but obese individual presents a favorable inflammation profile
    Antony D Karelis
    Department of Nutrition, University of Montreal, 2405 Chemin Cote Ste Catherine, Pavillon Liliane de Stewart, Montreal, Quebec, Canada H3T 1A8
    J Clin Endocrinol Metab 90:4145-50. 2005
    ..The purpose of this study was to investigate the inflammatory state in obese women displaying the "metabolically healthy but obese" (MHO) phenotype...
  43. ncbi request reprint Altered hepatic expression of SREBP-1 and PPARgamma is associated with liver injury in insulin-resistant lipodystrophic HIV-infected patients
    Maud Lemoine
    Universite Pierre et Marie Curie, Faculte de Medecine, Paris, F 75012 France
    AIDS 20:387-95. 2006
    ..Here, we examined whether their expression was modified and related to liver injury in HIV-infected patients...
  44. ncbi request reprint Adiponutrin: A new gene regulated by energy balance in human adipose tissue
    Yong Ming Liu
    Equipe d Accueil 3502 and Institut National de la Santé et de la Recherche Médicale INSERM Avenir and Department de Nutrition, Paris VI University, Paris, France
    J Clin Endocrinol Metab 89:2684-9. 2004
    ..These results indicate that adiponutrin gene expression in humans is highly regulated by changes in energy balance...
  45. ncbi request reprint [Lipodystrophies related to antiretroviral treatment of HIV infection]
    Jacqueline Capeau
    INSERM U680, Faculté de Médecine et Université Pierre et Marie Curie, Hopital Tenon AP HP, 27, rue Chaligny, 75012 Paris, France
    Med Sci (Paris) 22:531-6. 2006
    ..The treatment of lipodystrophy remains difficult and, at present, privileges the switch of the more deleterious drugs towards new molecules less aggressive for adipose tissue...
  46. pmc Inappropriately low glycated hemoglobin values and hemolysis in HIV-infected patients
    Marie Emilienne Diop
    AP HP, Hopital Tenon, Service de biochimie et d hormonologie, and Université Pierre et Marie Curie Paris 6, Faculte de Medecine, F 75020 France
    AIDS Res Hum Retroviruses 22:1242-7. 2006
    ..Self-monitoring of blood glucose and search for latent hemolysis should be promoted in diabetic HIV-infected patients...
  47. ncbi request reprint [Lipodystrophic syndromes: congenital or acquired diseases of adipose tissue]
    Jacqueline Capeau
    INSERM, U680, Universite Pierre et Marie Curie, site Saint Antoine, Faculte de Medecine, 27, rue Chaligny, 75571 Paris Cedex 12, France
    C R Biol 329:639-52; discussion 653-5. 2006
    ..Acquired forms are common and regroup the highly prevalent Metabolic Syndrome, hypercorticism together with lipodystrophy related to antiretroviral treatment of HIV-infected patients...