Marc Bardou

Summary

Country: France

Publications

  1. ncbi request reprint Meta-analysis: proton-pump inhibition in high-risk patients with acute peptic ulcer bleeding
    M Bardou
    Division of Gastroenterology, The McGill University Health Centre, Montreal General Hospital Site, Montreal, Quebec H3G 1A4, Canada
    Aliment Pharmacol Ther 21:677-86. 2005
  2. doi request reprint Pharmacokinetic and clinical evaluation of esomeprazole and ASA for the prevention of gastroduodenal ulcers in cardiovascular patients
    Marc Bardou
    Centre d Investigations Cliniques plurithématique 803 INSERM CIC P 803, CHU de Dijon, Bâtiment du Pr Marion, Dijon Cedex, France
    Expert Opin Drug Metab Toxicol 8:1199-208. 2012
  3. doi request reprint Treatment of pancreatic cancer: A narrative review of cost-effectiveness studies
    Marc Bardou
    Centre d Investigations Cliniques plurithématique 803, Inserm CIC P 803, CHU Dijon, Dijon Cedex, France Centre de Recherche Lipides, Nutrition Cancer U866, INSERM Institut National de la Santé et de la Recherche Médicale, Dijon Cedex, France Université de Bourgogne, Dijon Cedex, France Electronic address
    Best Pract Res Clin Gastroenterol 27:881-92. 2013
  4. doi request reprint Obesity and colorectal cancer
    Marc Bardou
    INSERM Centre d Investigations Cliniques Plurithématique 803 CIC P 803, CHU du Bocage, Dijon, France
    Gut 62:933-47. 2013
  5. doi request reprint Intravenous proton pump inhibitors: an evidence-based review of their use in gastrointestinal disorders
    Marc Bardou
    INSERM Centre d Investigations Cliniques Plurithématique 803 CIC P 803, Dijon Cedex, France
    Drugs 69:435-48. 2009
  6. ncbi request reprint Effect of chronic intake of NSAIDs and cyclooxygenase 2-selective inhibitors on esophageal cancer incidence
    Marc Bardou
    Division of Gastroenterology, Department of Medicine, McGill University and McGill University Health Center, Montreal, Quebec, Canada
    Clin Gastroenterol Hepatol 2:880-7. 2004
  7. doi request reprint Antitumoral effects of lipids A, clinical studies
    Marc Bardou
    Clinical Pharmacology Unit and Laboratory of Cardiovascular Experimental Physiology and Pharmacology, Faculty of Medicine, 7 bd Jeanne d Arc, BP87900, 21079 Dijon, France
    Adv Exp Med Biol 667:125-31. 2010
  8. doi request reprint Effect of statin therapy on colorectal cancer
    Marc Bardou
    Inserm CIC P 803, Faculte de Medecine, 21079 Dijon Cedex, France
    Gut 59:1572-85. 2010
  9. ncbi request reprint Antitumoral effects of lipids A, clinical studies
    Marc Bardou
    Clinical Pharmacology Unit and Laboratory of Cardiovascular Experimental Physiology and Pharmacology, Faculty of Medicine, 7 bd Jeanne d Arc, BP87900, 21079 Dijon, France
    Adv Exp Med Biol 667:125-31. 2009
  10. doi request reprint Preventing the gastrointestinal adverse effects of nonsteroidal anti-inflammatory drugs: from risk factor identification to risk factor intervention
    Marc Bardou
    Inserm CIC P 803, CHU de Dijon, 1, boulevard Jeanne d Arc, BP 1542, 21000 Dijon, France
    Joint Bone Spine 77:6-12. 2010

Detail Information

Publications63

  1. ncbi request reprint Meta-analysis: proton-pump inhibition in high-risk patients with acute peptic ulcer bleeding
    M Bardou
    Division of Gastroenterology, The McGill University Health Centre, Montreal General Hospital Site, Montreal, Quebec H3G 1A4, Canada
    Aliment Pharmacol Ther 21:677-86. 2005
    ..Recent data suggest that profound acid suppression may improve outcomes of patients in peptic ulcer bleeding...
  2. doi request reprint Pharmacokinetic and clinical evaluation of esomeprazole and ASA for the prevention of gastroduodenal ulcers in cardiovascular patients
    Marc Bardou
    Centre d Investigations Cliniques plurithématique 803 INSERM CIC P 803, CHU de Dijon, Bâtiment du Pr Marion, Dijon Cedex, France
    Expert Opin Drug Metab Toxicol 8:1199-208. 2012
    ....
  3. doi request reprint Treatment of pancreatic cancer: A narrative review of cost-effectiveness studies
    Marc Bardou
    Centre d Investigations Cliniques plurithématique 803, Inserm CIC P 803, CHU Dijon, Dijon Cedex, France Centre de Recherche Lipides, Nutrition Cancer U866, INSERM Institut National de la Santé et de la Recherche Médicale, Dijon Cedex, France Université de Bourgogne, Dijon Cedex, France Electronic address
    Best Pract Res Clin Gastroenterol 27:881-92. 2013
    ..The present paper reviews cost-effectiveness studies published on pancreatic cancer treatment...
  4. doi request reprint Obesity and colorectal cancer
    Marc Bardou
    INSERM Centre d Investigations Cliniques Plurithématique 803 CIC P 803, CHU du Bocage, Dijon, France
    Gut 62:933-47. 2013
    ..Many questions still remain unanswered: should preventive strategies specifically target obese patients? Is the risk of cancer great enough to propose prophylactic bariatric surgery in certain patients with obesity?..
  5. doi request reprint Intravenous proton pump inhibitors: an evidence-based review of their use in gastrointestinal disorders
    Marc Bardou
    INSERM Centre d Investigations Cliniques Plurithématique 803 CIC P 803, Dijon Cedex, France
    Drugs 69:435-48. 2009
    ..Indeed, the key difference between them, the ability to reach and to maintain a threshold gastric pH, might not necessarily translate into clinically significant differences...
  6. ncbi request reprint Effect of chronic intake of NSAIDs and cyclooxygenase 2-selective inhibitors on esophageal cancer incidence
    Marc Bardou
    Division of Gastroenterology, Department of Medicine, McGill University and McGill University Health Center, Montreal, Quebec, Canada
    Clin Gastroenterol Hepatol 2:880-7. 2004
    ..We investigated the effects of the selective cyclooxygenase 2 inhibitors (coxibs), rofecoxib and celecoxib, the nonselective nonsteroidal anti-inflammatory drugs (NSAIDs), and aspirin on esophageal cancer...
  7. doi request reprint Antitumoral effects of lipids A, clinical studies
    Marc Bardou
    Clinical Pharmacology Unit and Laboratory of Cardiovascular Experimental Physiology and Pharmacology, Faculty of Medicine, 7 bd Jeanne d Arc, BP87900, 21079 Dijon, France
    Adv Exp Med Biol 667:125-31. 2010
    ..Therefore clinical activity of such molecules deserves further experiments, likely in conjunction with chemotherapy...
  8. doi request reprint Effect of statin therapy on colorectal cancer
    Marc Bardou
    Inserm CIC P 803, Faculte de Medecine, 21079 Dijon Cedex, France
    Gut 59:1572-85. 2010
    ..The combination of statins with other drugs, such as low-dose aspirin or safer non-steroidal anti-inflammatory medications, may be useful in both the prevention and treatment of colorectal cancer...
  9. ncbi request reprint Antitumoral effects of lipids A, clinical studies
    Marc Bardou
    Clinical Pharmacology Unit and Laboratory of Cardiovascular Experimental Physiology and Pharmacology, Faculty of Medicine, 7 bd Jeanne d Arc, BP87900, 21079 Dijon, France
    Adv Exp Med Biol 667:125-31. 2009
    ..Therefore clinical activity of such molecules deserves further experiments, likely in conjunction with chemotherapy...
  10. doi request reprint Preventing the gastrointestinal adverse effects of nonsteroidal anti-inflammatory drugs: from risk factor identification to risk factor intervention
    Marc Bardou
    Inserm CIC P 803, CHU de Dijon, 1, boulevard Jeanne d Arc, BP 1542, 21000 Dijon, France
    Joint Bone Spine 77:6-12. 2010
    ..The toxicity advantages of cyclooxygenase-2 inhibitors seem modest and do not eliminate the need for this rational prescription strategy...
  11. pmc Is the beta3-adrenoceptor (ADRB3) a potential target for uterorelaxant drugs?
    Marc Bardou
    Laboratoire de Physiologie et Pharmacologie Cardiovasculaires Expérimentales, Faculte de Medecine, Universite de Bourgogne, Dijon Cedex, France
    BMC Pregnancy Childbirth 7:S14. 2007
    ..These compelling data confirm the clinical potential interest of ADRB3 agonists in the pharmacological management of preterm labour...
  12. ncbi request reprint Pantoprazole: from drug metabolism to clinical relevance
    Marc Bardou
    Centre d Investigations Cliniques, CHU de Dijon, France
    Expert Opin Drug Metab Toxicol 4:471-83. 2008
    ..Among the drugs available to inhibit acid secretion, proton pump inhibitors (PPI) have been shown to have the best efficacy-safety ratio and have been used widely...
  13. ncbi request reprint Pharmacological and biochemical study on the effects of selective phosphodiesterase inhibitors on human term myometrium
    M Bardou
    Department of Pharmacology, Faculty of Medicine Paris Ouest, Paris, France
    Naunyn Schmiedebergs Arch Pharmacol 360:457-63. 1999
    ..In conclusion, phosphodiesterase 4 inhibitors alone or combined with beta2-adrenoceptor agonists have potential interest as tocolytic agents...
  14. pmc Excessive alcohol consumption favours high risk polyp or colorectal cancer occurrence among patients with adenomas: a case control study
    M Bardou
    Hepatogastroenterology Unit, Antoine Beclere Hospital, 157, rue de la Porte de Trivaux F 92141 Clamart Cedex, France
    Gut 50:38-42. 2002
    ....
  15. pmc Functional, biochemical and molecular biological evidence for a possible beta(3)-adrenoceptor in human near-term myometrium
    M Bardou
    Department of Pharmacology, Faculty of Medicine Paris Ouest, 15 Rue de l Ecole de Médecine 75006 Paris, France
    Br J Pharmacol 130:1960-6. 2000
    ..The results presented provide the first evidence for the existence of the beta(3)-AR subtype in human near-term myometrium and suggest that the effects of SR 59119A might be mediated through an increase in cyclic AMP level...
  16. ncbi request reprint Hypoxic vasoconstriction of rat main pulmonary artery: role of endogenous nitric oxide, potassium channels, and phosphodiesterase inhibition
    M Bardou
    Laboratory of Cardiovascular Physiopathology and Pharmacology, Faculty of Medicine, Dijon, France
    J Cardiovasc Pharmacol 38:325-34. 2001
    ....
  17. ncbi request reprint Relaxant effects of selective phosphodiesterase inhibitors on U46619 precontracted human intralobar pulmonary arteries and role of potassium channels
    Marc Bardou
    Laboratory of Cardiovascular Physiopathology and Pharmacology, Faculty of Medicine, Jeanne d Arc, Dijon, France
    J Cardiovasc Pharmacol 40:153-61. 2002
    ....
  18. doi request reprint Celecoxib but not the combination of celecoxib+atorvastatin prevents the development of monocrotaline-induced pulmonary hypertension in the rat
    Zo Rakotoniaina
    Universite de Bourgogne, Dijon, France
    Naunyn Schmiedebergs Arch Pharmacol 378:241-51. 2008
    ..The combination of celecoxib and atorvastatin was unable to prevent MC-induced pulmonary hypertension, decreased endothelium-dependent vasorelaxation and showed a trend toward an increased in RVP that deserves further studies...
  19. ncbi request reprint The protective effect of HMG-CoA reductase inhibitors against monocrotaline-induced pulmonary hypertension in the rat might not be a class effect: comparison of pravastatin and atorvastatin
    Zo Rakotoniaina
    Laboratory of Experimental Cardiovascular Physiopathology and Pharmacology EA2979, University of Burgundy, BP 87900, 21000, Dijon, France
    Naunyn Schmiedebergs Arch Pharmacol 374:195-206. 2006
    ....
  20. ncbi request reprint The cyclooxygenase-2-selective inhibitors rofecoxib and celecoxib prevent colorectal neoplasia occurrence and recurrence
    Elham Rahme
    Division of Clinical Epidemiology, Montreal General Hospital, 1650 Cedar Avenue, Montreal, Quebec H3G 1A4, Canada
    Gastroenterology 125:404-12. 2003
    ....
  21. doi request reprint Effects of leptin on lipopolysaccharide-induced remodeling in an in vitro model of human myometrial inflammation
    Maeva Wendremaire
    Institut National de la Sante et de la Recherche Medicale INSERM, U866, Lipides, Nutrition, Cancer, Dijon, France
    Biol Reprod 88:45. 2013
    ..Our study strengthens the hypothesis that leptin plays a role in the development of obesity-related delivery disorders...
  22. ncbi request reprint ETA, mixed ETA/ETB receptor antagonists, and protein kinase C inhibitor prevent acute hypoxic pulmonary vasoconstriction: influence of potassium channels
    Françoise Goirand
    Laboratoire de Physiopathologie et Pharmacologie Cardiovasculaires Experimentales, Faculte de Medecine, Dijon, France
    J Cardiovasc Pharmacol 41:117-25. 2003
    ..These results suggest that BQ-123 operates through a mechanism independent of bisindolylmaleimide I-inhibited protein kinase C isoforms...
  23. ncbi request reprint The HMG-CoA reductase inhibitor, pravastatin, prevents the development of monocrotaline-induced pulmonary hypertension in the rat through reduction of endothelial cell apoptosis and overexpression of eNOS
    Pascal Guerard
    Laboratory of Experimental Cardiovascular Physiopathology and Pharmacology EA2979, IFR 100 Faculty of Medicine, BP 87900, 21000, Dijon, France
    Naunyn Schmiedebergs Arch Pharmacol 373:401-14. 2006
    ..Pravastatin reduces the development of monocrotaline-induced pulmonary hypertension and improves endothelium-dependent pulmonary artery relaxation, probably through a reduced apoptosis and a restored eNOS expression of endothelial cells...
  24. ncbi request reprint Arachidonic acid relaxes human pulmonary arteries through K+ channels and nitric oxide pathways
    Pascal Guerard
    Laboratory of Cardiovascular Physiopathology and Pharmacology, Faculty of Medicine, 7 bd Jeanne d Arc, BP 87900, 21079 Dijon Cedex, France
    Eur J Pharmacol 501:127-35. 2004
    ..CYP-dependent metabolites modulate arachidonic acid-induced relaxation through a pathway involving K(+) channels. K(ATP) channels are involved through a NOS-dependent pathway...
  25. doi request reprint International consensus recommendations on the management of patients with nonvariceal upper gastrointestinal bleeding
    Alan N Barkun
    Division of Gastroenterology, Montreal General Hospital Site, McGill University Health Centre, Montreal, Quebec, Canada
    Ann Intern Med 152:101-13. 2010
    ..A multidisciplinary group of 34 experts from 15 countries developed this update and expansion of the recommendations on the management of acute nonvariceal upper gastrointestinal bleeding (UGIB) from 2003...
  26. ncbi request reprint ADRB3 adrenergic receptor is a key regulator of human myometrial apoptosis and inflammation during chorioamnionitis
    Frederic Lirussi
    Laboratoire de Physiologie et Pharmacologie Cardiovasculaires Expérimentales LPPCE, EA279, IFR Santé STIC, Faculte de Medecine, Universite de Bourgogne, Dijon, France
    Biol Reprod 78:497-505. 2008
    ..This study shows that chorioamnionitis is associated with apoptosis of human myometrial cells. It emphasizes the potential therapeutic interest of ADRB3 agonists in the field of preterm labor and other inflammatory conditions...
  27. doi request reprint Biphasic Erk1/2 activation sequentially involving Gs and Gi signaling is required in beta3-adrenergic receptor-induced primary smooth muscle cell proliferation
    Tarik Hadi
    Lipides Nutrition Cancer, Dijon, France
    Biochim Biophys Acta 1833:1041-51. 2013
    ..Altogether, these data indicate that B3-AR-induced proliferation depends on the biphasic activation of Erk1/2 sequentially induced by the Gs/PKA/Src and Gi/Src/PI3K signaling pathways...
  28. doi request reprint Cost-effectiveness analysis: stress ulcer bleeding prophylaxis with proton pump inhibitors, H2 receptor antagonists
    Alan N Barkun
    Division of Gastroenterology, McGill University Health Center, McGill University, Montreal, Canada
    Value Health 16:14-22. 2013
    ..The literature also reports disparate rates of ventilator-assisted pneumonia (VAP) as side effects of these treatments. We compared the cost-effectiveness of these two prophylactic pharmacological options...
  29. doi request reprint Cost-effectiveness of proton-pump inhibition before endoscopy in upper gastrointestinal bleeding
    Salman Al-Sabah
    Division of General Surgery, McGill University, Montreal, Quebec, Canada
    Clin Gastroenterol Hepatol 6:418-25. 2008
    ..Randomized trials suggest high-dose proton-pump inhibitors (PPIs) administered before gastroscopy in suspected upper gastrointestinal bleeding downstage bleeding ulcer stigmata. We assessed the cost-effectiveness of this approach...
  30. pmc Phase I study of OM-174, a lipid A analogue, with assessment of immunological response, in patients with refractory solid tumors
    Nicolas Isambert
    INSERM CIC P803, CHU de Dijon, Bâtiment du Pr Marion, 14 rue Gaffarel, BP77908, 21079, Dijon Cedex, France
    BMC Cancer 13:172. 2013
    ..The present phase I trial was conducted to determine the maximum tolerated dose, the recommended phase II dose and biological response associated with OM-174 administered as intravenous infusion...
  31. doi request reprint Is routine second-look endoscopy effective after endoscopic hemostasis in acute peptic ulcer bleeding? A meta-analysis
    Sara El Ouali
    Division of Gastroenterology, McGill University Health Center, McGill University, Montreal, Quebec, Canada
    Gastrointest Endosc 76:283-92. 2012
    ..Routine second-look endoscopy in modern-era peptic ulcer bleeding (PUB) remains controversial...
  32. doi request reprint Effects of leptin on lipopolysaccharide-induced myometrial apoptosis in an in vitro human model of chorioamnionitis
    Maeva Wendremaire
    Centre d Investigations Cliniques plurithématique, Dijon, France
    Am J Obstet Gynecol 205:363.e1-9. 2011
    ..This study was aimed at assessing the role of leptin on human myometrium, by studying its receptor expression in pregnant myometrium and the interaction of leptin with inflammation-induced apoptosis...
  33. doi request reprint Prokinetics in acute upper GI bleeding: a meta-analysis
    Alan N Barkun
    Division of Gastroenterology, McGill University Health Center, McGill University, Montreal, Quebec, Canada
    Gastrointest Endosc 72:1138-45. 2010
    ..Recent data suggest that administration of prokinetics before gastroscopy may be useful in patients with acute upper GI bleeding (UGIB). Published studies are limited in the number of subjects evaluated, and the conclusions are disparate...
  34. doi request reprint Systemic increase in human maternal circulating CD14(+)CD16(-) MCP-1+ monocytes as a marker of labor
    Marc Bardou
    Centre d Investigations Cliniques plurithématique 803 INSERM CIC P 803, Dijon, France Center for Lipid Research, INSERM Institut National de la Santé et de la Recherche Médicale, Dijon, France CHU de Dijon, Dijon, France
    Am J Obstet Gynecol 210:70.e1-9. 2014
    ..To study the influence of pregnancy and labor on the proportion and level of activation of monocyte subpopulations in human pregnancy...
  35. doi request reprint Conflicts of interest ethics: silencing expertise in the development of international clinical practice guidelines
    Derek J Jones
    Division of Gastroenterology, Montreal General Hospital Site, McGill University Health Centre, Montreal, Quebec, Canada
    Ann Intern Med 156:809-16, W-283. 2012
    ..Optimal management of FCOIs to ensure independent, expert CPGs remains ethically contested...
  36. doi request reprint Endoscopic hemostasis in peptic ulcer bleeding for patients with high-risk lesions: a series of meta-analyses
    Alan N Barkun
    Divisions of Gastroenterology, The McGill University Health Centre, Montreal General Hospital Site, Montreal, Quebec, Canada
    Gastrointest Endosc 69:786-99. 2009
    ..Optimal endoscopic hemostasis remains undetermined. This was a systematic review of contemporary methods of endoscopic hemostasis for patients with bleeding ulcers that exhibited high-risk stigmata...
  37. ncbi request reprint Treatment costs to prevent or treat upper gastrointestinal adverse events associated with NSAIDs
    Elham Rahme
    Department of Medicine, McGill University and Research Institute, McGill University Health Center, Montreal, Quebec, Canada
    Drug Saf 27:1019-42. 2004
    ..Thus, from an economic perspective, the healthcare system would benefit from treating patients at risk of NSAID gastropathy with COX-2 inhibitors, but not those at no to low risk...
  38. doi request reprint Failure to renew prescriptions for gastroprotective agents to patients on continuous nonsteroidal anti-inflammatory drugs increases rate of upper gastrointestinal injury
    Isabelle Le Ray
    INSERM Centre d Investigations Cliniques Plurithématique 803, Centre Hospitalier Universitaire du Bocage, Dijon, France
    Clin Gastroenterol Hepatol 11:499-504.e1. 2013
    ..However, it is not clear how many physicians continue to prescribe GPAs to these patients, and whether stopping the GPA prescription increases GI complications...
  39. ncbi request reprint Consensus recommendations for managing patients with nonvariceal upper gastrointestinal bleeding
    Alan Barkun
    McGill University, Montreal, Quebec, Canada
    Ann Intern Med 139:843-57. 2003
    ..The management of patients with acute nonvariceal upper gastrointestinal bleeding has evolved substantially over the past 10 years amid a paucity of published consensus guidelines...
  40. ncbi request reprint Effects of phosphodiesterase inhibitors on hypoxic pulmonary vasoconstriction. Influence of K(+) channels and nitric oxide
    F Goirand
    Laboratoire de Physiopathologie et de Pharmacologie Cardiovasculaires Expérimentales, Faculte de Medecine, 7 bd Jeanne d Arc, BP 87900, 21079 cedex, Dijon, France
    Eur J Pharmacol 417:141-8. 2001
    ..These data illustrate different pharmacological profiles according to the phosphodiesterase inhibitors and support the potential interest of selective inhibitors as relaxant agents in pulmonary vessels...
  41. ncbi request reprint Non-steroidal anti-inflammatory drug prescribing patterns in general practice: comparison of a general practitioner-based survey and a pharmacy-based survey in France
    F Clinard
    Centre d Epidémiologie de Population, Faculte de Medecine, 7, boulevard Jeanne d Arc, BP 87900, 21079 Dijon Cedex, France
    Pharmacoepidemiol Drug Saf 10:329-38. 2001
    ....
  42. ncbi request reprint Non-steroidal anti-inflammatory and cytoprotective drug co-prescription in general practice. A general practitioner-based survey in France
    F Clinard
    Departement de Pharmacologie, Centre Regional de Pharmacovigilance, CHU de Dijon, France
    Eur J Clin Pharmacol 57:737-43. 2001
    ..can be limited by the prescription of cytoprotective agents. In order to assess determinants of NSAID-associated cytoprotective agent prescriptions in primary care practice, we performed a general practitioner (GP)-based study...
  43. ncbi request reprint Stimulation of the ADRB3 adrenergic receptor induces relaxation of human placental arteries: influence of preeclampsia
    C Rouget
    Laboratory of Cardiovascular Physiopathology and Pharmacology, Faculty of Medicine, 21079 Dijon Cedex, France
    Biol Reprod 74:209-16. 2006
    ..Even if preeclampsia is associated with an impairment of the ADRB3 responsiveness, ADRB3 agonists may have future pharmaceutical implications in the management of pregnancy-related disorders...
  44. doi request reprint Proton pump inhibitors vs. histamine 2 receptor antagonists for stress-related mucosal bleeding prophylaxis in critically ill patients: a meta-analysis
    Alan N Barkun
    Division of Gastroenterology, McGill University Health Center, McGill University, Montreal, Quebec, Canada
    Am J Gastroenterol 107:507-20; quiz 521. 2012
    ..The objective of this study was to evaluate the efficacy of PPIs vs. H2RAs in the prophylaxis of SRMB in critically ill adults with risk factors for bleeding...
  45. ncbi request reprint Neurokinins induce relaxation of human pulmonary vessels through stimulation of endothelial NK1 receptors
    Hakima Mechiche
    Laboratory of Vascular Pharmacology, Faculty of Medicine, Reims, France
    J Cardiovasc Pharmacol 41:343-55. 2003
    ..In conclusion, human pulmonary arteries and veins express endothelial NK(1) receptors that mediate relaxation through a combination of cyclooxygenase and nitric oxide activities and are subjected to rapid tachyphylaxis...
  46. ncbi request reprint Cancer relapse under chemotherapy: why TLR2/4 receptor agonists can help
    Ricardo P Garay
    EA2381, Universite Paris 7, Paris, France
    Eur J Pharmacol 563:1-17. 2007
    ..Therefore, parenteral TLR2/4 agonists seem promising molecules to prolong survival in cancer patients who relapse under chemotherapy...
  47. doi request reprint Relevance of new recommendations on routine antenatal prevention of rhesus immunization: an appraisal based on a retrospective analysis of all cases observed in two French administrative areas of 3 million inhabitants
    Stéphanie Boulet
    Department of Gynecology and Obstetrics, CHU du Bocage, 21079 Dijon Cedex, France
    Eur J Obstet Gynecol Reprod Biol 146:65-70. 2009
    ..To assess the potential impact of new guidelines recommending routine antenatal prophylaxis at 28 weeks of pregnancy on incidence, consequences and cost of rhesus immunization...
  48. ncbi request reprint High-dose intravenous proton pump inhibition following endoscopic therapy in the acute management of patients with bleeding peptic ulcers in the USA and Canada: a cost-effectiveness analysis
    A N Barkun
    Division of Gastroenterology, McGill University, Montreal, Quebec, Canada
    Aliment Pharmacol Ther 19:591-600. 2004
    ..The efficacy of high-dose intravenous proton pump inhibition has recently been shown, yet its cost-effectiveness remains poorly studied...
  49. ncbi request reprint [Inhibition of uterine contractions: new in vitro pharmacological approaches on the pregnant human myometrium]
    M Bardou
    LPPCE, , 7 Bd Jeanne d'Arc, BP 87900, 21079 Dijon, France
    Therapie 56:213-22. 2001
    ..In conclusion, phosphodiesterase 4 inhibitors alone or combined with beta 2-adrenoceptor agonists and beta 3-adrenoceptor agonists might have potential interest as tocolytic agents...
  50. doi request reprint Republished: obesity and colorectal cancer
    Marc Bardou
    INSERM Centre d Investigations Cliniques Plurithématique 803 CIC P 803, CHU du Bocage, Dijon, France
    Postgrad Med J 89:519-33. 2013
    ..Many questions still remain unanswered: should preventive strategies specifically target obese patients? Is the risk of cancer great enough to propose prophylactic bariatric surgery in certain patients with obesity? ..
  51. ncbi request reprint Cost-effectiveness of routine endoscopic biopsies for Helicobacter pylori detection in patients with non-ulcer dyspepsia
    Nicholaos Makris
    Division of Gastroenterology, McGill University Health Center and Department of Clinical Epidemiology, McGill University, Montreal, Quebec, Canada
    Gastrointest Endosc 58:14-22. 2003
    ..This study assesses the cost-effectiveness of performing routine biopsies for the detection of H pylori at upper endoscopy in these patients...
  52. ncbi request reprint Association between concomitant use of several systemic NSAIDs and an excess risk of adverse drug reaction. A case/non-case study from the French Pharmacovigilance system database
    François Clinard
    GEREPT Centre d Epidémiologie de Population de Bourgogne, Facultés de Médecine et Pharmacie, 7 bd Jeanne d Arc, BP 87900, 21079 Dijon Cedex, France
    Eur J Clin Pharmacol 60:279-83. 2004
    ..To examine whether the risk of some selected adverse effects increases with the number of systemic non-steroidal anti-inflammatory (NSAID) drugs...
  53. ncbi request reprint The cost-effectiveness of high-dose oral proton pump inhibition after endoscopy in the acute treatment of peptic ulcer bleeding
    A N Barkun
    Division of Gastroenterology, McGill University Health Centre, Montreal General Hospital Site, Quebec, Canada
    Aliment Pharmacol Ther 20:195-202. 2004
    ..Recent data suggest a role for high-dose oral proton pump inhibition in ulcer bleeding...
  54. doi request reprint Diagnosis and management of nonvariceal upper gastrointestinal bleeding
    Marc Bardou
    National Institute for Health and Medical Research INSERM, CIC P 803, Department of Gastroenterology, Centre Hospitalier Universitaire de Dijon, 14 rue Gaffarel, BP77908, 21079 Dijon, France marc bardou u bourgogne fr
    Nat Rev Gastroenterol Hepatol 9:97-104. 2012
    ..Antiplatelet therapy should be suspended and resumed in 3-5 days. Finally, all patients should be tested for Helicobacter pylori by serology in the acute setting...
  55. ncbi request reprint Increased superoxide anion production is associated with early atherosclerosis and cardiovascular dysfunctions in a rabbit model
    Bertrand Collin
    Laboratory of Cardiovascular and Experimental Physiopathology and Pharmacology, Faculty of Medicine, University of Burgundy, 7, boulevard Jeanne d Arc, 21079, Dijon Cedex, BP 87900, France
    Mol Cell Biochem 294:225-35. 2007
    ..As HC could generate an alteration in the oxidative status, we studied the effects of a 1-month cholesterol diet on cardiovascular oxidative stress...
  56. pmc SAR150640, a selective beta3-adrenoceptor agonist, prevents human myometrial remodelling and activation of matrix metalloproteinase in an in vitro model of chorioamnionitis
    F Lirussi
    Centre d Investigations Cliniques plurithématique 803 INSERM CIC P 803, Dijon, France
    Br J Pharmacol 159:1354-66. 2010
    ..As we have shown that beta(3)-adrenoceptors act as regulators of myometrial inflammation, we wanted to investigate the potential role of beta(3)-adrenoceptors in preventing uterine remodelling induced by inflammation...
  57. ncbi request reprint Hospitalization for gastrointestinal bleeding associated with non-steroidal anti-inflammatory drugs among elderly patients using low-dose aspirin: a retrospective cohort study
    E Rahme
    Division of Clinical Epidemiology, Montreal General Hospital L10 408, 1650 Cedar Ave, Montreal, Quebec H3G 1A4, Canada
    Rheumatology (Oxford) 46:265-72. 2007
    ..It is unclear, however, whether this fact holds good among patients taking ASA. We compared GI hospitalization rates among elderly patients taking celecoxib, NS-NSAIDs, celecoxib and ASA or NS-NSAIDs and ASA...
  58. ncbi request reprint Relaxation of proximal and distal isolated human bronchi by halothane, isoflurane and desflurane
    F J Mercier
    University of Medicine Paris Ouest and UFR Biomédicale des St Pères, Paris, France
    Eur Respir J 20:286-92. 2002
    ..Although adenosine triphosphate-sensitive K+ channels are involved in these relaxant effects, they are unlikely to explain the observed differences between the three volatile anaesthetics...
  59. pmc Nociceptin inhibits airway microvascular leakage induced by HCl intra-oesophageal instillation
    Celine Rouget
    UPRES EA220 Pharmacology, University of Versailles and UFR Biomédicale des Saints Pères, 45 Rue des Saints Peres, F 75006 Paris, France
    Br J Pharmacol 141:1077-83. 2004
    ..Nociceptin is likely to act at a pre-junctional level, by inhibiting tachykinin release, since it was unable to prevent SP-induced airway plasma extravasation...
  60. ncbi request reprint In vitro and in vivo pharmacological characterization of ethyl-4-[trans-4-[((2S)-2-hydroxy-3-[4-hydroxy-3[(methylsulfonyl)amino]-phenoxy]propyl) amino]cyclohexyl]benzoate hydrochloride (SAR150640), a new potent and selective human beta3-adrenoceptor agoni
    Tiziano Croci
    Exploratory Research Department, Sanofi Midy Research Center, Sanofi Aventis, SPA, Via G B Piranesi, 38, 20137 Milan, Italy
    J Pharmacol Exp Ther 321:1118-26. 2007
    ..These findings indicate a potential for the therapeutic use of SAR150640 in mammals during preterm labor...
  61. doi request reprint Management of acute bleeding from a peptic ulcer
    Ian M Gralnek
    Department of Gastroenterology and Gastrointestinal Outcomes Unit, Rambam Health Care Campus and Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    N Engl J Med 359:928-37. 2008
  62. ncbi request reprint SSR126768A (4-chloro-3-[(3R)-(+)-5-chloro-1-(2,4-dimethoxybenzyl)-3-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl]-N-ethyl-N-(3-pyridylmethyl)-benzamide, hydrochloride): a new selective and orally active oxytocin receptor antagonist for the prevention of preterm
    Claudine Serradeil-Le Gal
    Exploratory Research Department, Sanofi Synthelabo Recherche, 195 route d Espagne, 31036 Toulouse Cedex, France
    J Pharmacol Exp Ther 309:414-24. 2004
    ..This molecule could find therapeutic application as a tocolytic agent for acute and chronic oral management of preterm labor...
  63. ncbi request reprint Response to "Potentially flawed interpretation of data by Andriulli et al."
    Alan N Barkun
    Am J Gastroenterol 100:2133; author reply 2133-4. 2005