Beverley Balkau

Summary

Country: France

Publications

  1. ncbi A review of the metabolic syndrome
    B Balkau
    INSERM U780 IFR69, 16, avenue Paul Vaillant Couturier, 94807 Villejuif Cedex, France
    Diabetes Metab 33:405-13. 2007
  2. pmc Secretory granule neuroendocrine protein 1 (SGNE1) genetic variation and glucose intolerance in severe childhood and adult obesity
    Nabila Bouatia-Naji
    CNRS 8090 Institute of Biology, Pasteur Institute, Lille, France
    BMC Med Genet 8:44. 2007
  3. pmc The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies
    Stephane Cauchi
    CNRS UMR8090, Institut de Biologie de Lille, Génomique et Physiologie Moléculaire des Maladies Métaboliques, Lille, France
    BMC Med Genet 9:45. 2008
  4. pmc Analysis of KLF transcription factor family gene variants in type 2 diabetes
    Ruth Gutierrez-Aguilar
    UMR8090, CNRS, Institute of Biologie Institute Pasteur de Lille, Lille, France
    BMC Med Genet 8:53. 2007
  5. pmc Analysis of common PTPN1 gene variants in type 2 diabetes, obesity and associated phenotypes in the French population
    Claire Cheyssac
    CNRS UMR 8090, Institut de Biologie de Lille, Institut Pasteur, 59019 Lille, France
    BMC Med Genet 7:44. 2006
  6. pmc Evaluating the association of common PBX1 variants with type 2 diabetes
    Konsta Duesing
    Genomic Medicine, Imperial College London, Hammersmith Campus, Du Cane Rd, London W12 0NN, UK
    BMC Med Genet 9:14. 2008
  7. pmc Evaluating the association of common APOA2 variants with type 2 diabetes
    Konsta Duesing
    Genomic Medicine, Imperial College London, Hammersmith Campus, Du Cane Rd, London, W12 0NN, UK
    BMC Med Genet 10:13. 2009
  8. ncbi The incidence and persistence of the NCEP (National Cholesterol Education Program) metabolic syndrome. The French D.E.S.I.R. study
    B Balkau
    INSERM U258, Villejuif, France
    Diabetes Metab 29:526-32. 2003
  9. ncbi Frequency of the WHO metabolic syndrome in European cohorts, and an alternative definition of an insulin resistance syndrome
    Beverley Balkau
    INSERM Unit 258, Villejuif Cedex, France
    Diabetes Metab 28:364-76. 2002
  10. ncbi Epidemiological data on postprandial glycaemia
    B Balkau
    Diabetes Metab 32:2S5-9. 2006

Collaborators

Detail Information

Publications106 found, 100 shown here

  1. ncbi A review of the metabolic syndrome
    B Balkau
    INSERM U780 IFR69, 16, avenue Paul Vaillant Couturier, 94807 Villejuif Cedex, France
    Diabetes Metab 33:405-13. 2007
    ..The metabolic syndrome is an entity which merits attention from both the medical profession and public health authorities...
  2. pmc Secretory granule neuroendocrine protein 1 (SGNE1) genetic variation and glucose intolerance in severe childhood and adult obesity
    Nabila Bouatia-Naji
    CNRS 8090 Institute of Biology, Pasteur Institute, Lille, France
    BMC Med Genet 8:44. 2007
    ..The aim of this study is to analyze associations of SGNE1 genetic variation with obesity and metabolism related quantitative traits...
  3. pmc The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies
    Stephane Cauchi
    CNRS UMR8090, Institut de Biologie de Lille, Génomique et Physiologie Moléculaire des Maladies Métaboliques, Lille, France
    BMC Med Genet 9:45. 2008
    ....
  4. pmc Analysis of KLF transcription factor family gene variants in type 2 diabetes
    Ruth Gutierrez-Aguilar
    UMR8090, CNRS, Institute of Biologie Institute Pasteur de Lille, Lille, France
    BMC Med Genet 8:53. 2007
    ..Moreover, several of these proteins have been implicated in glucose homeostasis, making them candidate genes for involvement in type 2 diabetes (T2D)...
  5. pmc Analysis of common PTPN1 gene variants in type 2 diabetes, obesity and associated phenotypes in the French population
    Claire Cheyssac
    CNRS UMR 8090, Institut de Biologie de Lille, Institut Pasteur, 59019 Lille, France
    BMC Med Genet 7:44. 2006
    ....
  6. pmc Evaluating the association of common PBX1 variants with type 2 diabetes
    Konsta Duesing
    Genomic Medicine, Imperial College London, Hammersmith Campus, Du Cane Rd, London W12 0NN, UK
    BMC Med Genet 9:14. 2008
    ..PBX1 is a biological candidate gene for type 2 diabetes at the 1q21-q24 susceptibility locus. The aim of this study was to evaluate the association of common PBX1 variants with type 2 diabetes in French Caucasian subjects...
  7. pmc Evaluating the association of common APOA2 variants with type 2 diabetes
    Konsta Duesing
    Genomic Medicine, Imperial College London, Hammersmith Campus, Du Cane Rd, London, W12 0NN, UK
    BMC Med Genet 10:13. 2009
    ..The aim of this study was to examine if HapMap phase II tag SNPs in APOA2 are associated with type 2 diabetes and quantitative traits in French Caucasian subjects...
  8. ncbi The incidence and persistence of the NCEP (National Cholesterol Education Program) metabolic syndrome. The French D.E.S.I.R. study
    B Balkau
    INSERM U258, Villejuif, France
    Diabetes Metab 29:526-32. 2003
    ..The frequency of this syndrome at baseline and its incidence and persistence at three years is studied in a French population...
  9. ncbi Frequency of the WHO metabolic syndrome in European cohorts, and an alternative definition of an insulin resistance syndrome
    Beverley Balkau
    INSERM Unit 258, Villejuif Cedex, France
    Diabetes Metab 28:364-76. 2002
    ....
  10. ncbi Epidemiological data on postprandial glycaemia
    B Balkau
    Diabetes Metab 32:2S5-9. 2006
    ..The cardiovascular disease in diabetic patients may be due to the presence of other cardiovascular risk factors associated with diabetes...
  11. ncbi Prediction of the risk of cardiovascular mortality using a score that includes glucose as a risk factor. The DECODE Study
    B Balkau
    IINSERM U258 IFR69, 16 Avenue Paul Vaillant Couturier, 94807 Villejuif Cedex, France
    Diabetologia 47:2118-28. 2004
    ..This article develops 5- and 10-year risk scores for cardiovascular mortality that include glucose concentrations as well as known diabetes status...
  12. pmc Prescreening tools for diabetes and obesity-associated dyslipidaemia: comparing BMI, waist and waist hip ratio. The D.E.S.I.R. Study
    B Balkau
    INSERM, U258, Villejuif, France
    Eur J Clin Nutr 60:295-304. 2006
    ..To compare the sensitivities of BMI, waist circumference and waist hip ratio (WHR) in identifying subjects who should be screened for diabetes and/or for obesity-associated dyslipidaemia...
  13. ncbi Consequences of change in waist circumference on cardiometabolic risk factors over 9 years: Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR)
    Beverley Balkau
    Institut National de la Sante et de la Recherche Medicale, unité 780 IFR69, Epidemiological and Biostatistical Research, Villejuif, France
    Diabetes Care 30:1901-3. 2007
  14. pmc International Day for the Evaluation of Abdominal Obesity (IDEA): a study of waist circumference, cardiovascular disease, and diabetes mellitus in 168,000 primary care patients in 63 countries
    Beverley Balkau
    INSERM U780 IFR69, Research in Epidemiology and Biostatistics, 16 Ave Paul Vaillant Couturier, 94807 Villejuif, France
    Circulation 116:1942-51. 2007
    ....
  15. ncbi The impact of 3-year changes in lifestyle habits on metabolic syndrome parameters: the D.E.S.I.R study
    Beverley Balkau
    INSERM U780 IFR69, Villejuif, France
    Eur J Cardiovasc Prev Rehabil 13:334-40. 2006
    ..The effect of lifestyle changes in cohorts of free-living populations has been surprisingly little evaluated...
  16. ncbi Two hour plasma glucose is not unequivocally predictive for early death in men with impaired fasting glucose: more results from the Paris Prospective Study
    B Balkau
    INSERM U258 IFR69 and Faculty of Medicine University Paris XI, Villejuif, France
    Diabetologia 45:1224-30. 2002
    ..0 mmol/l; IFG: 6.1-6.9 mmol/l; normal-FPG: <6.1 mmol/l)...
  17. ncbi Hyperinsulinemia predicts fatal liver cancer but is inversely associated with fatal cancer at some other sites: the Paris Prospective Study
    B Balkau
    Institut National de la Santé et de la Recherche Médicale Unité 258 and the Faculty of Medicine, University Paris Sud, Villejuif, France
    Diabetes Care 24:843-9. 2001
    ..To investigate whether insulin is a risk factor for death by site-specific cancers...
  18. ncbi Is there a glycemic threshold for mortality risk?
    B Balkau
    Institut National de la Santé et de la Recherche Médicale INSERM U258, Villejuif, France
    Diabetes Care 22:696-9. 1999
    ..To determine whether there are thresholds for fasting and for 2-h glucose above which the risk of death from all causes and from coronary heart disease (CHD) increases...
  19. ncbi Insulin dose and cardiovascular risk factors in type 1 diabetic children and adolescents
    B Balkau
    INSERM U21, Villejuif, France
    Diabetes Metab 24:143-50. 1998
    ..It is concluded that in these Type 1 diabetic children the insulin dose for a given level of metabolic control (our surrogate measure of insulin resistance) was related to a single cardiovascular risk factor: triglyceride concentrations...
  20. ncbi Proposed criteria for the diagnosis of diabetes: evidence from a French epidemiological study (D.E.S.I.R.)
    B Balkau
    INSERM Unite 21, Villejuif, France
    Diabetes Metab 23:428-34. 1997
    ..The major increase in cardiovascular risk factors would appear to occur at 6.1 mM, for men, whereas the increase in the combination of risk factors was at the more conservative cut-off of 7.0 mM...
  21. ncbi The DECODE study. Diabetes epidemiology: collaborative analysis of diagnostic criteria in Europe
    B Balkau
    INSERM U258, 16 Avenue Paul Vaillant Couturier, 94807 Villlejuif Cedex France
    Diabetes Metab 26:282-6. 2000
    ..1 mmol/l (200 mg/dl)), are now even less likely to be screened as diabetic, despite the fact that they have a risk of premature death of the same order as other diabetic subjects...
  22. ncbi High blood glucose concentration is a risk factor for mortality in middle-aged nondiabetic men. 20-year follow-up in the Whitehall Study, the Paris Prospective Study, and the Helsinki Policemen Study
    B Balkau
    INSERM U21, Villejuif, France
    Diabetes Care 21:360-7. 1998
    ..To assess the association between high but nondiabetic blood glucose levels and the risk of death from all causes, coronary heart disease (CHD), cardiovascular disease, and neoplasms...
  23. ncbi Insulin resistance: an independent risk factor for cardiovascular disease?
    B Balkau
    INSERM Unit 258, Villejuif, France
    Diabetes Obes Metab 1:S23-31. 1999
    ....
  24. doi The lactase persistence genotype is associated with body mass index and dairy consumption in the D.E.S.I.R. study
    Amel Lamri
    INSERM, U695, Genetic Determinants of Type 2 Diabetes and Its Vascular Complications, Paris, France Univ Paris Diderot, Sorbonne Paris Cité, UMRS 695, UFR de Medecine Site Bichat, Paris, France
    Metabolism 62:1323-9. 2013
    ..Our aim was to test in this study, the association of rs4988235 with BMI and related metabolic diseases, in interaction with dairy product consumption...
  25. pmc Nine-year incident diabetes is predicted by fatty liver indices: the French D.E.S.I.R. study
    Beverley Balkau
    INSERM CESP Center for Research in Epidemiology and Population Health, Villejuif, France
    BMC Gastroenterol 10:56. 2010
    ..e.s.i.r)...
  26. ncbi Calcium consumption and insulin resistance syndrome parameters. Data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR)
    Peggy Drouillet
    INSERM U780 IFR69, Villejuif, France
    Nutr Metab Cardiovasc Dis 17:486-92. 2007
    ..In this study we have examined the relationship between dietary calcium and the established parameters of the insulin resistance syndrome...
  27. ncbi Weight, the metabolic syndrome, and coronary heart disease in type 2 diabetes: associations among a national French sample of adults with diabetes-the ENTRED study
    Teresa A Hillier
    Institut National de la Santé et de la Recherche Médicale U258 IFR69, University Paris XI, Villejuif, France
    J Cardiometab Syndr 1:318-25. 2006
    ..8-2.9). The authors suggest that obesity alone--and particularly when the MS is present--increases CHD risk in patients with T2DM. High levels of high-density lipoprotein may modify this relationship...
  28. ncbi Reproducibility of the diagnosis of diabetes over a 30-month follow-up: the Paris Prospective Study
    E Eschwege
    Faculty of Medicine, University of Paris XI, Villejuif, France
    Diabetes Care 24:1941-4. 2001
    ..To describe the change in diabetic status over 30 months...
  29. ncbi Dairy products and the metabolic syndrome in a prospective study, DESIR
    Frederic Fumeron
    INSERM, U695, Genetic Determinants of Type 2 Diabetes and Its Vascular Complications, Univ Paris Diderot, Sorbonne Paris Cité, UMRS 695, UFR de Medecine Site Bichat, Paris 75018, France
    J Am Coll Nutr 30:454S-63S. 2011
    ....
  30. pmc High baseline insulin levels associated with 6-year incident observed sleep apnea
    Beverley Balkau
    Institut Nationale de la Santé et de la Recherché Médicale, CESP Centre for research in Epidemiology and Population Health, Unité 1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease over the lifecourse, Villejuif, France
    Diabetes Care 33:1044-9. 2010
    ..We evaluate risk factors for incident observed sleep apnea in a general population not selected for sleep disturbances...
  31. doi Anthropometrics, body shape over 12 years and risk of cancer events in pre- and post-menopausal women
    Guy Fagherazzi
    INSERM, Centre for Research in Epidemiology and Population Health CESP, CESP U1018, Nutrition, Hormones and Women s Health Team, F 94805, Villejuif, France
    Int J Cancer 133:740-8. 2013
    ..20 (1.10-1.30)], respectively as was long birth length in post-menopausal women [HR: 1.18 (1.07-1.30) compared to medium birth length]. These results suggest independent roles of height and WC on cancer risk, through different pathways...
  32. doi HbA1c, fasting plasma glucose and the prediction of diabetes: Inter99, AusDiab and D.E.S.I.R
    Soraya Soulimane
    Universite Paris Sud 11, UMRS 1018, Villejuif, France
    Diabetes Res Clin Pract 96:392-9. 2012
    ..With diabetes defined by HbA1c≥6.5% and/or FPG≥7.0mmol/l and/or diabetes treatment, we investigated HbA1c and fasting plasma glucose (FPG) thresholds/change-points above which the incidence of diabetes increases...
  33. pmc Predicting diabetes: clinical, biological, and genetic approaches: data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR)
    Beverley Balkau
    INSERM U780 IFR69, Villejuif, France University Paris Sud, Orsay, France
    Diabetes Care 31:2056-61. 2008
    ..To provide a simple clinical diabetes risk score and to identify characteristics that predict later diabetes using variables available in the clinic setting as well as biological variables and polymorphisms...
  34. ncbi ABCA1 single nucleotide polymorphisms on high-density lipoprotein-cholesterol and overweight: the D.E.S.I.R. study
    Isabelle Porchay
    Institut National de la Sante et de la Recherche Medicale, Unité 695, Xavier Bichat School of Medicine, Paris, France
    Obesity (Silver Spring) 14:1874-9. 2006
    ..This study suggests that ABCA1 gene polymorphisms modulate HDL-C concentrations, in interaction with BMI, and, thus, they might influence cardiovascular risk in the general population...
  35. doi Smallness for gestational age interacts with high mobility group A2 gene genetic variation to modulate height
    Nabila Bouatia-Naji
    INSERM, Unité 690, Robert Debre Hospital, Paris F 75019, France
    Eur J Endocrinol 160:557-60. 2009
    ..Genome-wide association studies have identified a single nucleotide polymorphism (SNP) (rs1042725) in the high mobility group A2 gene (HMGA2) that consistently associates with height variability but its interaction with SGA is unknown...
  36. ncbi Use of HbA1c in predicting progression to diabetes in French men and women: data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR)
    Celine Droumaguet
    INSERM U258 IFR69, 16 Avenue Paul Vaillant Couturier, 94807 Villejuif Cedex, France
    Diabetes Care 29:1619-25. 2006
    ..The predictive value of A1C, in comparison to FPG, is evaluated for 6-year incident diabetes...
  37. ncbi Ferritin and transferrin are associated with metabolic syndrome abnormalities and their change over time in a general population: Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR)
    Istvan S Vari
    Institut National de la Sante et de la Recherche Medicale, unité 780 IFR69, Epidemiological and Biostatistical Research, Villejuif, France
    Diabetes Care 30:1795-801. 2007
    ..The aim of this work was to study cross-sectional and longitudinal relations between iron stocks (ferritin) and the iron transport protein (transferrin) with the metabolic syndrome and its abnormalities...
  38. pmc Birth weight, body silhouette over the life course, and incident diabetes in 91,453 middle-aged women from the French Etude Epidemiologique de Femmes de la Mutuelle Generale de l'Education Nationale (E3N) Cohort
    Blandine de Lauzon-Guillain
    INSERM, ERI 20, EA 4045, Institut Gustave Roussy, Villejuif, France
    Diabetes Care 33:298-303. 2010
    ..Low birth weight is also associated with a higher diabetes incidence. We aimed to examine to what extent the evolution of body shape, from childhood to adulthood, is related to incident diabetes in late adulthood...
  39. pmc Metabolic syndrome in a sub-Saharan African setting: central obesity may be the key determinant
    Leopold Fezeu
    INSERM U780 IFR69, Epidemiological and Biostatistical Research, 16 Avenue Paul Vaillant Couturier, 94807 Villejuif, France
    Atherosclerosis 193:70-6. 2007
    ....
  40. doi Center effect on ankle-brachial index measurement when using the reference method (Doppler and manometer): results from a large cohort study
    Emilie Vierron
    INSERM, CIC 202, Tours, France
    Am J Hypertens 22:718-22. 2009
    ..We aimed to assess, in a French multicenter cohort, the center effect associated with arterial pressure (AP) and ABI measurements using the reference method and using a semiautomatic device...
  41. doi Association of vitronectin and plasminogen activator inhibitor-1 levels with the risk of metabolic syndrome and type 2 diabetes mellitus. Results from the D.E.S.I.R. prospective cohort
    Marie Christine Alessi
    U626, INSERM, Marseille, France
    Thromb Haemost 106:416-22. 2011
    ..0009). In conclusion, baseline plasma vitronectin is a marker of incident MetS at nine years. Its predictive ability for MetS and T2DM should not be assessed independently of PAI-1 levels...
  42. ncbi Consumption of artificially and sugar-sweetened beverages and incident type 2 diabetes in the Etude Epidemiologique aupres des femmes de la Mutuelle Generale de l'Education Nationale-European Prospective Investigation into Cancer and Nutrition cohort
    Guy Fagherazzi
    Center for Research in Epidemiology and Population Health, Villejuif, France
    Am J Clin Nutr 97:517-23. 2013
    ..It has been extensively shown, mainly in US populations, that sugar-sweetened beverages (SSBs) are associated with increased risk of type 2 diabetes (T2D), but less is known about the effects of artificially sweetened beverages (ASBs)...
  43. ncbi Alcohol consumption and insulin resistance syndrome parameters: associations and evolutions in a longitudinal analysis of the French DESIR cohort
    Michel Vernay
    INSERM U258 IFR69, Universite Paris XI, Villejuif, France
    Ann Epidemiol 14:209-14. 2004
    ..To determine the effects of average alcohol consumption and changes in alcohol intake on the insulin resistance syndrome parameters in a 3-year follow-up study...
  44. ncbi Gamma-glutamyltransferase activity and development of the metabolic syndrome (International Diabetes Federation Definition) in middle-aged men and women: Data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR) cohort
    Philippe Andre
    Institut National de la Santé et de la Recherche Médicale INSERM Unité 780 IFR69, Epidemiological and Biostatistical Research, Villejuif, France
    Diabetes Care 30:2355-61. 2007
    ..Our aim was to study the association of GGT with the development of the metabolic syndrome (MetS)...
  45. pmc High plasma leptin predicts an increase in subcutaneous adiposity in children and adults
    A Kettaneh
    INSERM U 780, IFR 69, Faculte de Medecine Paris Sud, Villejuif, France
    Eur J Clin Nutr 61:719-26. 2007
    ..To investigate the hypothesis that plasma leptin may predict adiposity changes...
  46. pmc Weight change and changes in the metabolic syndrome as the French population moves towards overweight: the D.E.S.I.R. cohort
    T A Hillier
    Institut National de la Santé et de la Recherche Médicale U258, Villejuif, France
    Int J Epidemiol 35:190-6. 2006
    ..How weight change affects the metabolic syndrome (MS) and its parameters is unknown, particularly, in a leaner European population such as the French prospective D.E.S.I.R. cohort...
  47. pmc Physical activity and insulin sensitivity: the RISC study
    Beverley Balkau
    INSERM 780, Villejuif, University Paris Sud, Orsay, France
    Diabetes 57:2613-8. 2008
    ..Physical activity is a modifiable risk factor for type 2 diabetes, partly through its action on insulin sensitivity. We report the relation between insulin sensitivity and physical activity measured by accelerometry...
  48. pmc Are the same clinical risk factors relevant for incident diabetes defined by treatment, fasting plasma glucose, and HbA1c?
    Beverley Balkau
    INSERM, CESP Center for Research in Epidemiology and Population Health, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease over the lifecourse, U1018, Villejuif, France
    Diabetes Care 34:957-9. 2011
    ..To compare incidences and risk factors for diabetes using seven definitions, with combinations of pharmacological treatment, fasting plasma glucose (FPG) ≥7.0 mmol/L, and HbA(1c) ≥6.5%...
  49. ncbi Association of common variants in NPPA and NPPB with blood pressure does not translate into kidney damage in a general population study
    Suliya Maimaitiming
    INSERM, U695, Paris, France
    J Hypertens 28:1230-3. 2010
    ....
  50. ncbi Association between socioeconomic status and adiposity in urban Cameroon
    Leopold Fezeu
    INSERM Unité 258, Villejuif, France
    Int J Epidemiol 35:105-11. 2006
    ..As the relation between socioeconomic status (SES) and obesity may depend on the stage of development of a country, this relation is assessed in adults from urban Cameroon...
  51. pmc Body mass index, diabetes, and mortality in French women: explaining away a "paradox"
    Martin Lajous
    From the aDepartment of Epidemiology, Harvard School of Public Health, Boston, MA bCenter for Research on Population Health, National Institute of Public Health, Cuernavaca, Mexico cNational Institute of Health and Medical Research Inserm, Center for Research in Epidemiology and Population Health CESP, U1018, Gustave Roussy Cancer Institute, Villejuif, France dParis South University, UMRS 1019, Villejuif, France eDepartment of Biostatistics, Harvard School of Public Health, Boston, MA fHarvard MIT Division of Health Sciences and Technology, Boston, MA
    Epidemiology 25:10-4. 2014
    ..Obesity is associated with increased mortality in the general population but, paradoxically, with decreased mortality in persons with diabetes...
  52. ncbi The PPARG Pro12Ala polymorphism is associated with a decreased risk of developing hyperglycemia over 6 years and combines with the effect of the APM1 G-11391A single nucleotide polymorphism: the Data From an Epidemiological Study on the Insulin Resistance
    Riphed Jaziri
    INSERM, U695, Xavier Bichat Medical School, BP 416, 16 rue Henri Huchard, 75870 Paris Cedex 18, France
    Diabetes 55:1157-62. 2006
    ..Cumulative rather than synergistic effects of PPARG Pro12Ala and APM1 SNPs on diabetes risk are suggested...
  53. pmc Dairy consumption and the incidence of hyperglycemia and the metabolic syndrome: results from a french prospective study, Data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR)
    Frederic Fumeron
    1INSERM U695, Paris, France
    Diabetes Care 34:813-7. 2011
    ..We assess the influence of dairy products on 9-year incident MetS and on impaired fasting glycemia and/or type 2 diabetes (IFG/T2D)...
  54. ncbi Contribution of the metabolic syndrome to sudden death risk in asymptomatic men: the Paris Prospective Study I
    Jean Philippe Empana
    INSERM Avenir, Epidemiology of Sudden Death in the Population, Paris XI University, Paris, France
    Eur Heart J 28:1149-54. 2007
    ..To compare the risk of sudden death and non-sudden death from myocardial infarction associated with the metabolic syndrome (MetS) in asymptomatic men...
  55. ncbi Ten-year changes in central obesity and BMI in rural and urban Cameroon
    Leopold K Fezeu
    Health of Population in Transition Research Group, Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon
    Obesity (Silver Spring) 16:1144-7. 2008
    ..To compare the 10-year changes in the distribution of adiposity in rural and urban Cameroonian populations...
  56. ncbi Associations of the -344 T>C and the 3097 G>A polymorphisms of CYP11B2 gene with hypertension, type 2 diabetes, and metabolic syndrome in a French population
    Naïma Muñoz Bellili
    Institut National de la Santé et de la Recherche Médicale INSERM U695, Déterminants Génétiques du Diabète de Type 2 et de ses Complications Cardiovasculaires, Faculte Xavier Bichat, Universite Denis Diderot Paris 7, Paris, France
    Am J Hypertens 23:660-7. 2010
    ..We assessed the association of two polymorphisms -344 T>C and the 3097 G>A in the aldosterone synthase gene (CYP11B2) with prevalent and incident hypertension (HT), type 2 diabetes (T2D), and the metabolic syndrome (MetS)...
  57. ncbi A pharmacoepidemiological assessment of the effect of statins and fibrates on fibrinogen concentration
    Patrick Maison
    Service de Pharmacologie Clinique, Hopital Henri Mondor, AP HP, 94010 Creteil Cedex, France
    Atherosclerosis 160:155-60. 2002
    ..In conclusion, fibrates in contrast with statins may combine lipid-lowering with a beneficial effect on fibrinogen. This effect is independent of changes in cholesterol and triglyceride concentrations...
  58. ncbi Ferritin and transferrin are both predictive of the onset of hyperglycemia in men and women over 3 years: the data from an epidemiological study on the Insulin Resistance Syndrome (DESIR) study
    Frederic Fumeron
    INSERM U695, Xavier Bichat Medical School, BP 416, 16 rue Henri Huchard, 75870 Paris Cedex 18, France
    Diabetes Care 29:2090-4. 2006
    ....
  59. ncbi Adiponectin gene polymorphisms and adiponectin levels are independently associated with the development of hyperglycemia during a 3-year period: the epidemiologic data on the insulin resistance syndrome prospective study
    Frederic Fumeron
    EA 3516, Interactions Gènes Environnement dans les Pathologies Métaboliques à Risque Cardiovasculaire, Faculte Xavier Bichat, Paris, France
    Diabetes 53:1150-7. 2004
    ..Adiponectin gene SNPs may have several phenotypic effects that co-occur with the development of the metabolic syndrome...
  60. ncbi [Metabolic syndrome or insulin resistance syndrome. Recent epidemiological data]
    E Eschwege
    INSERM U 258, Hôpital Paul Brousse F 94807 VILLEJUIF Cedex
    Ann Endocrinol (Paris) 64:S32-6. 2003
    ..These findings imply to identify these at risk subjects and to define the optimal preventive management strategy...
  61. pmc Waist circumference and obesity-related abnormalities in French and Cameroonian adults: the role of urbanization and ethnicity
    L Fezeu
    INSERM U780 IFR69, Epidemiological and Biostatistical Research, Villejuif, France
    Int J Obes (Lond) 34:446-53. 2010
    ..To evaluate the effect of urbanization and ethnicity on correlations between waist circumference (WC) and obesity-related cardiovascular risk factors...
  62. ncbi Gender differences in the relation between fibrinogen, tissue-type plasminogen activator antigen and markers of insulin resistance: effects of smoking. D.E.S.I.R. Study Group. Data from an Epidemiological Study on Insulin Resistance Syndrome
    L I Mennen
    INSERM, Unit 258, Faculty of Medicine Paris Sud, Villejuif, France
    Thromb Haemost 82:1106-11. 1999
    ..The strong modifying effect of smoking habits does not completely explain this gender difference...
  63. ncbi From policemen to policies: what is the future for 2-h glucose? The Kelly West Lecture, 2000
    E Eschwege
    Faculty of Medicine, University of Paris XI, Villejuif, France
    Diabetes Care 24:1945-50. 2001
    ..0 mmol/l, with diabetes diagnosed by one isolated postchallenge hyperglycemia (IPH) (FPG <7.0 mmol/l and a 2-h plasma glucose concentration > or =11.1 mmol/l), or with impaired glucose tolerance (IGT)...
  64. ncbi Trends in antimicrobial drug use in the community--France, 1981-1992
    D Guillemot
    Institut National de la Sante et de la Recherche Medicale, Unité 21, Faculte de Medecine Paris Sud, Villejuif, France
    J Infect Dis 177:492-7. 1998
    ..The proper use of cephalosporins must be encouraged, and vigilance is required in view of the increased improper use of fluoroquinolones, mainly for respiratory tract infections with a presumed viral etiology...
  65. pmc Three-year increase of gamma-glutamyltransferase level and development of type 2 diabetes in middle-aged men and women: the D.E.S.I.R. cohort
    P Andre
    INSERM U780 IFR69, 16 Avenue Paul Vaillant Couturier, 94807 Villejuif Cedex, France
    Diabetologia 49:2599-603. 2006
    ..Among hepatic markers, gamma-glutamyltransferase (GGT) is the main predictor for development of type 2 diabetes, but there are no data to date on changes in GGT and type 2 diabetes incidence...
  66. ncbi Habitual diet in four populations of African origin: a descriptive paper on nutrient intakes in rural and urban Cameroon, Jamaica and Caribbean migrants in Britain
    L I Mennen
    INSERM, Unit 258, 16 Avenue Paul Vaillant Couturier, F 94807 Villejuif Cedex, France
    Public Health Nutr 4:765-72. 2001
    ..This trend may be due to the transition in the habitual diet, with increasing (saturated) fat and decreasing fruit and vegetable intakes, both within and between countries...
  67. ncbi Fibrinogen: a possible link between alcohol consumption and cardiovascular disease? DESIR Study Group
    L I Mennen
    INSERM Unit 21 and the Faculty of Medicine Paris Sud, Villejuif IRSA, La Riche, France
    Arterioscler Thromb Vasc Biol 19:887-92. 1999
    ..If fibrinogen is a causal risk factor for cardiovascular disease, it may be 1 of the variables that explain the protective effect of moderate alcohol consumption on cardiovascular disease...
  68. ncbi Trends in aspirin, paracetamol and non-steroidal anti-inflammatory drug use in children between 1981 and 1992 in France
    P Maison
    INSERM Unite 21, Faculty of Medicine Paris Sud, Villejuif, France
    Eur J Clin Pharmacol 54:659-64. 1998
    ..Their efficacy and adverse effects have often been debated and new AADs have been introduced over the past few years. The aim of this study was to assess the characteristics of the use of AADs in children in France, and their trends...
  69. ncbi Hepatic markers and development of type 2 diabetes in middle aged men and women: a three-year follow-up study. The D.E.S.I.R. Study (Data from an Epidemiological Study on the Insulin Resistance syndrome)
    P Andre
    INSERM U258 IFR69, University Paris XI, 16 Avenue Paul Vaillant Couturier, 94807 Villejuif, France
    Diabetes Metab 31:542-50. 2005
    ..This study investigates the association between hepatic markers and the 3-year risk of diabetes...
  70. ncbi Microalbuminuria and markers of the atherosclerotic process: the D.E. S.I.R. study
    L I Mennen
    INSERM, Unit 258, and the Faculty of Medicine Paris Sud, Villejuif, France
    Atherosclerosis 154:163-9. 2001
    ..The results of this study suggest that in non-diabetic men, microalbuminuria is associated with fibrinogen, but with tPA-ag only when concomitant with hypertension...
  71. ncbi HbA1c, fasting and 2 h plasma glucose in current, ex- and never-smokers: a meta-analysis
    Soraya Soulimane
    CESP U1018, INSERM, 16 Avenue Paul Vaillant Couturier, 94807, Villejuif Cedex, France
    Diabetologia 57:30-9. 2014
    ..The relationships between smoking and glycaemic variables have not been well explored. We compared HbA1c, fasting plasma glucose (FPG) and 2 h plasma glucose (2H-PG) in current, ex- and never-smokers...
  72. pmc Practical way to assess metabolic syndrome using a continuous score obtained from principal components analysis
    T A Hillier
    National Health and Medical Research Institute INSERM, U258 IFR69, Villejuif, France
    Diabetologia 49:1528-35. 2006
    ..We devised a practical continuous score to assess the metabolic syndrome, and assessed whether this syndrome score predicts incident diabetes and cardiovascular disease...
  73. ncbi Ethnic influences on the relations between abdominal subcutaneous and visceral adiposity, liver fat, and cardiometabolic risk profile: the International Study of Prediction of Intra-Abdominal Adiposity and Its Relationship With Cardiometabolic Risk/Intra-
    Julie Anne Nazare
    Centre de Recherche de l Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Quebec, Canada
    Am J Clin Nutr 96:714-26. 2012
    ..Ethnic differences in cardiometabolic risk (CMR) may be related to patterns of ethnic-specific body fat distribution...
  74. pmc Menopausal hormone therapy and new-onset diabetes in the French Etude Epidemiologique de Femmes de la Mutuelle Générale de l'Education Nationale (E3N) cohort
    B de Lauzon-Guillain
    INSERM, ERI, EA, Institut Gustave Roussy, Villejuif, France
    Diabetologia 52:2092-100. 2009
    ..The purpose of this study was to evaluate the influence of various MHTs, according to their formulation and route of administration, on new-onset diabetes in a cohort of postmenopausal French women...
  75. pmc Confirmation of associations between ion channel gene SNPs and QTc interval duration in healthy subjects
    L Gouas
    INSERM, U582, Institut de Myologie, Paris, France
    Eur J Hum Genet 15:974-9. 2007
    ..In conclusion, our study confirms the reported associations between QTc length and KCNQ1 rs757,092 and KCNH2 rs3,815,459...
  76. ncbi Endocannabinoid receptor 1 gene variations increase risk for obesity and modulate body mass index in European populations
    Michael Benzinou
    CNRS 8090 Institute of Biology, Pasteur Institute, Lille, France
    Hum Mol Genet 17:1916-21. 2008
    ..As CB1 is a drug target for obesity, a pharmacogenetic analysis of the endocannabinoid blockade obesity treatment may be of interest to identify best responders...
  77. ncbi Waist circumference and the metabolic syndrome predict the development of elevated albuminuria in non-diabetic subjects: the DESIR Study
    Fabrice Bonnet
    Department of Diabetology Endocrinology, CRNH, Hospital Edouard Herriot, INSERM U 449, Lyon, France
    J Hypertens 24:1157-63. 2006
    ..We investigated in both sexes whether an elevated waist circumference (WC) or the presence of the metabolic syndrome (MetS) predict the development of elevated albuminuria at 6 years...
  78. ncbi Impact of common type 2 diabetes risk polymorphisms in the DESIR prospective study
    Martine Vaxillaire
    UMR8090 and Institute of Biology, Lille 2 University, CNRS and Pasteur Institute, Lille, France
    Diabetes 57:244-54. 2008
    ..However, the relevance of these genes for disease prediction has not been extensively tested...
  79. ncbi Screen-detected diabetes, hypertension and hypercholesterolemia as predictors of cardiovascular mortality in five populations of Asian origin: the DECODA study
    Tomoko Nakagami
    Diabetes Center, Tokyo Women s Medical University, Tokyo, Japan
    Eur J Cardiovasc Prev Rehabil 13:555-61. 2006
    ..The aims of this study were to assess the predictive value of glucose tolerance status as a risk factor for CVD and identify a high-risk group for fatal CVD in population-based studies of Asians...
  80. ncbi The fasting plasma glucose cut-point predicting a diabetic 2-h OGTT glucose level depends on the phenotype
    Tomoko Nakagami
    Diabetes Res Clin Pract 55:35-43. 2002
    ..1 mmol/l. There seems to be ethnic differences with respect to optimal FPG cut-point, and different screening strategies may be necessary in different parts of the world...
  81. ncbi A genome-wide association study identifies novel risk loci for type 2 diabetes
    Robert Sladek
    Department of Human Genetics, McGill University and Genome Quebec Innovation Centre, Montreal H3A 1A4, Canada
    Nature 445:881-5. 2007
    ..These associations explain a substantial portion of disease risk and constitute proof of principle for the genome-wide approach to the elucidation of complex genetic traits...
  82. ncbi Bardet-Biedl syndrome gene variants are associated with both childhood and adult common obesity in French Caucasians
    Michael Benzinou
    Section of Genomic Medicine, Faculty of Medicine, Imperial College, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK
    Diabetes 55:2876-82. 2006
    ..g., dyslipidemia, hyperglycemia), a complication previously described in BBS patients. In summary, our preliminary data suggest that variations at BBS genes are associated with risk of common obesity...
  83. ncbi Transcription factor TCF7L2 genetic study in the French population: expression in human beta-cells and adipose tissue and strong association with type 2 diabetes
    Stephane Cauchi
    CNRS Institute of Biology, Pasteur Institute, Lille, France
    Diabetes 55:2903-8. 2006
    ..These data provide evidence that TCF7L2 is a major determinant of type 2 diabetes risk in European populations and suggests that this transcription factor plays a key role in glucose homeostasis...
  84. ncbi The prevalence of and factors associated with diabetic retinopathy in the Australian population
    Robyn J Tapp
    The International Diabetes Institute, Melbourne, Vic, Australia
    Diabetes Care 26:1731-7. 2003
    ..To determine the prevalence and factors associated with diabetic retinopathy in the Australian population and to estimate the time difference between disease onset and clinical diagnosis of type 2 diabetes...
  85. ncbi Non-synonymous polymorphisms in melanocortin-4 receptor protect against obesity: the two facets of a Janus obesity gene
    Fanny Stutzmann
    CNRS 8090 Institute of Biology, Pasteur Institute, Lille, France
    Hum Mol Genet 16:1837-44. 2007
    ..These results also emphasize the importance of the MC4R signalling tonus to prevent obesity, even in the context of our current obesogenic environment...
  86. ncbi Insulin resistance, insulin response, and obesity as indicators of metabolic risk
    Ele Ferrannini
    Department of Internal Medicine, University of Pisa, Via Roma, 67 I 56100 Pisa, Italy
    J Clin Endocrinol Metab 92:2885-92. 2007
    ..Moreover, the differential impact of IR viz. insulin response has not been evaluated...
  87. ncbi Variation in FTO contributes to childhood obesity and severe adult obesity
    Christian Dina
    CNRS 8090 Institute of Biology, Pasteur Institute, Lille, France
    Nat Genet 39:724-6. 2007
    ..The at-risk haplotype yields a proportion of attributable risk of 22% for common obesity. We conclude that FTO contributes to human obesity and hence may be a target for subsequent functional analyses...
  88. ncbi TCF7L2 variation predicts hyperglycemia incidence in a French general population: the data from an epidemiological study on the Insulin Resistance Syndrome (DESIR) study
    Stephane Cauchi
    Imperial College, Section of Genomic Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK
    Diabetes 55:3189-92. 2006
    ..We conclude that the TCF7L2 T at-risk allele variation (rs7903146) predicts hyperglycemia incidence in a general French population, possibly through a deleterious effect on insulin secretion...
  89. ncbi Comment on "A common genetic variant is associated with adult and childhood obesity"
    Christian Dina
    CNRS 8090 Institute of Biology, Pasteur Institute, Lille, France
    Science 315:187; author reply 187. 2007
    ..We attempted to replicate this result in 10,265 Caucasian individuals, combining family-based, case-control, and general population studies, but found no support for a major role of this variant in obesity...
  90. ncbi Age- and sex-specific prevalence of diabetes and impaired glucose regulation in 11 Asian cohorts
    Qing Qiao
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    Diabetes Care 26:1770-80. 2003
    ..To report the age- and sex-specific prevalence of diabetes and impaired glucose regulation (IGR) according to revised World Health Organization criteria for diabetes in Asian populations...
  91. ncbi Analysis of novel risk loci for type 2 diabetes in a general French population: the D.E.S.I.R. study
    Stephane Cauchi
    CNRS 8090 Institute of Biology, Pasteur Institute, Lille, France
    J Mol Med (Berl) 86:341-8. 2008
    ..E.S.I.R. prospective cohort. However, in contrast to TCF7L2, the contribution of novel loci to T2D incidence seems only modest in the general middle-aged French population and should be replicated in larger cohorts...
  92. doi Influence of the ACE gene insertion/deletion polymorphism on insulin sensitivity and impaired glucose tolerance in healthy subjects
    Fabrice Bonnet
    Department of Medicine, Endocrinology Unit, Centre Hospitalier Universitaire, université Rennes, Rennes, France
    Diabetes Care 31:789-94. 2008
    ..The purpose of this study was to investigate the relationship between the ACE gene I/D polymorphism and both insulin sensitivity and glucose intolerance in a large cohort of healthy subjects...
  93. ncbi The burden of diabetes-related mortality in France in 2002: an analysis using both underlying and multiple causes of death
    Isabelle Romon
    French Institute for Public Health Surveillance, institut de veille sanitaire InVS, 12 Rue du Val d Osne, 94415 Saint Maurice Cedex, France
    Eur J Epidemiol 23:327-34. 2008
    ..To describe the burden of diabetes-related mortality in France...
  94. pmc Screening for diabetes
    Beverley Balkau
    Diabetes Care 31:1084-5. 2008
  95. doi A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels
    Nabila Bouatia-Naji
    CNRS UMR 8090 Institute of Biology, Pasteur Institute of Lille and Lille 2 Droit et Santé University, 59019 Lille, France
    Science 320:1085-8. 2008
    ..We speculate that G6PC2 regulates FPG by modulating the set point for glucose-stimulated insulin secretion in pancreatic beta cells...
  96. ncbi ACDC/adiponectin polymorphisms are associated with severe childhood and adult obesity
    Nabila Bouatia-Naji
    Centre National de la Recherche Scientifique UMR8090, Pasteur Institute of Lille, France
    Diabetes 55:545-50. 2006
    ..In summary, our study suggests that variations at the ACDC/adiponectin gene are associated with risk of severe forms of obesity. However, the mechanisms underlying these possible associations are not fully understood...
  97. ncbi Association of glucose metabolism, smoking and cardiovascular risk factors with incident peripheral arterial disease: the DESIR study
    Robyn J Tapp
    INSERM Unite 258 IFR69, University Paris XI, Villejuif, France Department of Epidemiology and Preventive Medicine, Monash University, Australia
    Atherosclerosis 190:84-9. 2007
    ..We determined the 6-year incidence of peripheral arterial disease (PAD) in a French population and assessed the association of glucose metabolism, smoking, cardiovascular risk factors and physical activity with incident PAD...
  98. pmc The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population
    Martine Vaxillaire
    CNRS 8090 Institute of Biology, Pasteur Institute, Lille, France
    Diabetes 57:2253-7. 2008
    ..We evaluated, in a general French population, the contribution of the GCKR rs1260326-P446L polymorphism to quantitative metabolic parameters and to dyslipidemia and hyperglycemia risk...
  99. ncbi Albuminuria is evident in the early stages of diabetes onset: results from the Australian Diabetes, Obesity, and Lifestyle Study (AusDiab)
    Robyn J Tapp
    International Diabetes Institute, Melbourne, Australia
    Am J Kidney Dis 44:792-8. 2004
    ..We determined the prevalence of and factors associated with albuminuria in an Australian population and examined the association of albuminuria with glucose tolerance...
  100. ncbi Prevalence of the metabolic syndrome and its relation to all-cause and cardiovascular mortality in nondiabetic European men and women
    Gang Hu
    Diabetes and Genetic Epidemiology Unit, Department of Epidemiology and Health Promotion, National Public Health Institute, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    Arch Intern Med 164:1066-76. 2004
    ..This study examined the age- and sex-specific prevalence of the metabolic syndrome and its association with all-cause and cardiovascular mortality in nondiabetic European men and women...
  101. doi Urinary albumin excretion is a risk factor for diabetes mellitus in men, independently of initial metabolic profile and development of insulin resistance. The DESIR Study
    Jean Michel Halimi
    Francois Rabelais University, CHRU Tours, Service de néphrologie immunologie clinique, Tours, France
    J Hypertens 26:2198-206. 2008
    ..Whether UAE predicts the development of diabetes mellitus, independently of the presence or the development of the metabolic syndrome, is unclear, in particular, in women...